CN105267586A - Medicine externally used for treating tetanus - Google Patents

Abstract

The invention provides a medicine externally used for treating tetanus. The medicine comprises a sterilization group and a treatment group, which are prepared according to the mass unit, wherein the sterilization group comprises 60-80g of Danshen root, 60-80g of baical skullcap root, 60-80g of garlic, 60-80g of seaweed, 60-80g of coptis root, 60-80g of Szechuan lovage rhizome, 60-80g of cassia bark, 60-80g of clove and 60-80g of biond magnolia flower bud; and the treatment group comprises 40-60g of heartleaf houttuynia herb, 40-60g of rice bean, 40-60g of platycodon root, 30-50g of Chinese gentian, 30-50g of baikal skullcap root, 30-50g of copperleaf herb, 30-50g of java brucea fruit, 30-50g of root of largeleaf gentian, 30-50g of common threewingnut root, 30-50g of shepherdspurse herb, 30-50g of ramie root, 20-40g of carbonized human hair, 20-40g of peanut coat, 20-40g of Szechuan lovage rhizome, 20-40g of rhizoma corydalis, 20-40g of frankincense, 20-40g of myrrh, 20-40g of catechu, 20-40g of dragon's blood and 10-30g of liquorice root. The medicine is simple in proportioning, is convenient to use and has good treatment effects on tetanus.

Description

One is used for the treatment of tetanic medicine for external use

technical field:

The present invention relates to traditional Chinese medicine technical field of pharmaceuticals, particularly relate to one and be used for the treatment of tetanic medicine for external use.

background technology:

TCM tetanus, opinion is said, and tetanus is because of soldier's violent trauma damage, and ailment said due to cold or exposure attacks it, propagates meridians, cold and heat are more done, and health is anti-strong, and locked mouth is not opened, notably pathogen invading ZANG-organ, then uncurable disease.If skin ulcer is not recovered for a long time, Rong Wei is weak, and muscle not life, the skin ulcer eye person of not conforming to, ailment said due to cold or exposure also can enter outward.And cause tetanus.

Tetanus pathogenic bacterium are clostridium tetanis, are obligate anaerobic, and Gram's staining is positive.Nature is distributed in, especially being common in soil with spore state.This bacterium has very strong drag to environment, can boiling resistance.Morbidity principal element is exactly anaerobic environment.During wound, clostridium tetani can pollute deep tissue (as blind pipe wound, deep are stabbed).If wound collar extension is less, there is slough in wound, clot fills, or filling tension, ischemia etc., just define the anaerobic environment that is applicable to the breeding of this bacteria growing.If there is aerobe to infect simultaneously, the latter will consume oxygen residual in wound, makes primary disease be easier to occur.Tetanus signs is malaise, dizziness, headache, masticatory atonia, local muscle feel nervous, pull pain, hyperreflexia etc.Classical symptom is on the basis that muscle tonus shrinks (myotonia, harden), the strong spasm of paroxysmal, and affected muscle group is masticatory muscles at first usually, and order is facial expression muscle, neck, the back of the body, abdomen, extremity flesh subsequently, is finally diaphram.The sign of corresponding appearance is: difficulty in opening mouth (gnathospasma), frown, contracting under bicker, grin " forced smile ", tonic neck, head swing back; When the back of the body, abdominal muscle shrinks simultaneously, and because back muscle group is comparatively strong, thus trunk is twisted into bow, in conjunction with neck, the going down on one's knees of extremity, curved elbow, partly the spasm attitude such as clenches fist, formation " opisthotonus " or " pleurothotonos "; After diaphram is influenced, cyanosis on the face and lips during outbreak, can there is asphyxia in dysventilation.Above-mentioned outbreak because of slight stimulation, can be brought out as light, sound, contact, drinking-water etc.

In prior art, as 2014106374963 disclose one and treat tetanic Chinese medicine preparation, the raw material of Chinese medicine of selection and weight portion respectively: Rhizoma Arisaematis 15 parts, Zaocys 10 parts, Radix Clematidis 12 parts, Periostracum Cicadae 15 parts, Bombyx Batryticatus 20 parts, 15 parts, Rhizoma Gastrodiae, Radix Saposhnikoviae 18 parts, Radix Aconiti Kusnezoffii 15 parts, Flos Chrysanthemi 30 parts, Rhizoma Typhonii 9 parts, Scorpio 10 parts.For another example 2015104665494 the tetanic Chinese medicine for the treatment of is disclosed, Radix Aconiti Coreani 5-8 part, Radix Zanthoxyli 3-5 part, Radix Achyranthis 3-10 part, Faeces Passeris 2-5 part, Herba Melastomatis Dodecandri 2-5 part, Foliumet Ramulus Evodiae 3-8 part, Caulis Sargentodoxae 5-15 part, Rhizoma Paridis 3-8 part, Herba Duchesneae Indicae 2-5 part, Carapax Eretmochelydis 5-8 part, Herba Thesii Longifolii 3-5 part, Flos Daturae 3-5 part, Herba Ocimi (Herba Ocimi Pilosi) 2-4 part, Rhizoma Polygonati Verticillati 2-9 part.Also have the tetanic various compositions of some numerous treatments in prior art, but it is only enumerate treatment example, and without any zoopery or the checking of pathogenic bacterium experimental data.It is simple that the present invention aims to provide a kind of proportioning, easy to use, good for tetanus therapeutic effect, suppresses the effective one of clostridium tetani to be used for the treatment of tetanic medicine for external use.

summary of the invention:

The object of the invention is to based on prior art, provide a kind of proportioning simple, easy to use, good for tetanus therapeutic effect, suppress the effective one of clostridium tetani to be used for the treatment of tetanic medicine for external use.

To achieve these goals, the invention provides one and be used for the treatment of tetanic medicine for external use, comprise the sterilization group according to mass unit preparation and treatment group, wherein:

Sterilization group is: Radix Salviae Miltiorrhizae, Radix Scutellariae, Bulbus Allii, Sargassum, Rhizoma Coptidis, Rhizoma Chuanxiong, Cortex Cinnamomi, Flos Caryophylli, each 60-80g of Flos Magnoliae;

Treatment group is: each 40-60g of Herba Houttuyniae, Semen Phaseoli, Radix Platycodonis, Radix Gentianae, Radix Scutellariae, Herba Acalyphae, Fructus Bruceae, Qin Jiu, Radix Tripterygii Wilfordii, Herba Capsellae, each 30-50g of Radix Boehmeriae, the each 20-40g of Crinis Carbonisatus, Testa arachidis hypogaeae, Rhizoma Chuanxiong, Rhizoma Corydalis, Olibanum, Myrrha, catechu, Sanguis Draxonis, Radix Glycyrrhizae 10-30g.

Or, be used for the treatment of tetanic medicine for external use, comprise the sterilization group according to mass unit preparation and treatment group, it is characterized in that:

Sterilization group is: Radix Salviae Miltiorrhizae, Radix Scutellariae, Bulbus Allii, Sargassum, Rhizoma Coptidis, Rhizoma Chuanxiong, Cortex Cinnamomi, Flos Caryophylli, each 60-70 of Flos Magnoliae;

Treatment group is: each 40-50g of Herba Houttuyniae, Semen Phaseoli, Radix Platycodonis, Radix Gentianae, Radix Scutellariae, Herba Acalyphae, Fructus Bruceae, Qin Jiu, Radix Tripterygii Wilfordii, Herba Capsellae, each 30-40g of Radix Boehmeriae, the each 20-30g of Crinis Carbonisatus, Testa arachidis hypogaeae, Rhizoma Chuanxiong, Rhizoma Corydalis, Olibanum, Myrrha, catechu, Sanguis Draxonis, Radix Glycyrrhizae 10-20g.

Or, comprise the sterilization group according to mass unit preparation and treatment group, it is characterized in that:

Sterilization group is: Radix Salviae Miltiorrhizae, Radix Scutellariae, Bulbus Allii, Sargassum, Rhizoma Coptidis, Rhizoma Chuanxiong, Cortex Cinnamomi, Flos Caryophylli, each 50-80g of Flos Magnoliae;

Treatment group is: each 50-60g of Herba Houttuyniae, Semen Phaseoli, Radix Platycodonis, Radix Gentianae, Radix Scutellariae, Herba Acalyphae, Fructus Bruceae, Qin Jiu, Radix Tripterygii Wilfordii, Herba Capsellae, each 40-50g of Radix Boehmeriae, the each 30-40g of Crinis Carbonisatus, Testa arachidis hypogaeae, Rhizoma Chuanxiong, Rhizoma Corydalis, Olibanum, Myrrha, catechu, Sanguis Draxonis, Radix Glycyrrhizae 20-30g.

Or, comprise the sterilization group according to mass unit preparation and treatment group, it is characterized in that:

Sterilization group is: Radix Salviae Miltiorrhizae, Radix Scutellariae, Bulbus Allii, Sargassum, Rhizoma Coptidis, Rhizoma Chuanxiong, Cortex Cinnamomi, Flos Caryophylli, each 55-75g of Flos Magnoliae;

Treatment group is: each 45-55g of Herba Houttuyniae, Semen Phaseoli, Radix Platycodonis, Radix Gentianae, Radix Scutellariae, Herba Acalyphae, Fructus Bruceae, Qin Jiu, Radix Tripterygii Wilfordii, Herba Capsellae, each 35-45g of Radix Boehmeriae, the each 35-35g of Crinis Carbonisatus, Testa arachidis hypogaeae, Rhizoma Chuanxiong, Rhizoma Corydalis, Olibanum, Myrrha, catechu, Sanguis Draxonis, Radix Glycyrrhizae 15-25g.

The group that the present invention sterilized is prepared as powder: mixing after each for sterilization group component being pulverized, obtain mixture, soak after 24 hours, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, through ultraviolet radiation disinfection 10 seconds, obtain antibacterial of the present invention.Be used alone sterilization group, be watered and stir, mass ratio is 1:8.

Treatment group of the present invention is prepared as powder: mixing after each for treatment group component being pulverized, obtain mixture, soak after 24 hours, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, through ultraviolet radiation disinfection 10 seconds, obtain treatment group of the present invention, after treatment group is used in sterilization group, use treatment group to be watered to stir, mass ratio is 1:4.

During encapsulation, sterilization group and treatment group encapsulate in two soft capsules of plastics respectively, and are bonded side by side by two soft capsules.

Using method: external, is watered flushing, first rinses by sterilization group, then rinses by treatment group.

Advantage of the present invention: proportioning is simple, easy to use, good for tetanus therapeutic effect, suppresses clostridium tetani effective.

The present invention suppresses anaerobe with sterilization group, in the process of flushing, suppresses, kills clostridium tetani.

With treatment group, flushing drug treatment is carried out to the wound after sterilization operation, with the Herba Houttuyniae of evacuation of pus, Semen Phaseoli, Radix Platycodonis for monarch drug; Treatment group with the Radix Gentianae of bringing down a fever, Radix Scutellariae, the Herba Acalyphae of removing toxic substances, Fructus Bruceae, the Qin Jiu of subduing swelling and relieving pain, Radix Tripterygii Wilfordii, the Herba Capsellae of cooling blood for hemostasis, Radix Boehmeriae are ministerial drug; Anastaltic Crinis Carbonisatus, Testa arachidis hypogaeae, the Rhizoma Chuanxiong of circulation of qi promoting hemostasis and pain-relieving, Rhizoma Corydalis, the Olibanum of granulation promoting pain relieving, Myrrha, catechu, Sanguis Draxonis are adjuvant drug, with Radix Glycyrrhizae for making medicine.

detailed description of the invention:

Be used for the treatment of tetanic medicine for external use, comprise the sterilization group according to mass unit preparation and treatment group, wherein:

Sterilization group is: Radix Salviae Miltiorrhizae, Radix Scutellariae, Bulbus Allii, Sargassum, Rhizoma Coptidis, Rhizoma Chuanxiong, Cortex Cinnamomi, Flos Caryophylli, each 60-80g of Flos Magnoliae;

Treatment group is: each 40-60g of Herba Houttuyniae, Semen Phaseoli, Radix Platycodonis, Radix Gentianae, Radix Scutellariae, Herba Acalyphae, Fructus Bruceae, Qin Jiu, Radix Tripterygii Wilfordii, Herba Capsellae, each 30-50g of Radix Boehmeriae, the each 20-40g of Crinis Carbonisatus, Testa arachidis hypogaeae, Rhizoma Chuanxiong, Rhizoma Corydalis, Olibanum, Myrrha, catechu, Sanguis Draxonis, Radix Glycyrrhizae 10-30g.

Or, be used for the treatment of tetanic medicine for external use, comprise the sterilization group according to mass unit preparation and treatment group, it is characterized in that:

Sterilization group is: Radix Salviae Miltiorrhizae, Radix Scutellariae, Bulbus Allii, Sargassum, Rhizoma Coptidis, Rhizoma Chuanxiong, Cortex Cinnamomi, Flos Caryophylli, each 60-70 of Flos Magnoliae;

Treatment group is: each 40-50g of Herba Houttuyniae, Semen Phaseoli, Radix Platycodonis, Radix Gentianae, Radix Scutellariae, Herba Acalyphae, Fructus Bruceae, Qin Jiu, Radix Tripterygii Wilfordii, Herba Capsellae, each 30-40g of Radix Boehmeriae, the each 20-30g of Crinis Carbonisatus, Testa arachidis hypogaeae, Rhizoma Chuanxiong, Rhizoma Corydalis, Olibanum, Myrrha, catechu, Sanguis Draxonis, Radix Glycyrrhizae 10-20g.

Or, comprise the sterilization group according to mass unit preparation and treatment group, it is characterized in that:

Sterilization group is: Radix Salviae Miltiorrhizae, Radix Scutellariae, Bulbus Allii, Sargassum, Rhizoma Coptidis, Rhizoma Chuanxiong, Cortex Cinnamomi, Flos Caryophylli, each 50-80g of Flos Magnoliae;

Treatment group is: each 50-60g of Herba Houttuyniae, Semen Phaseoli, Radix Platycodonis, Radix Gentianae, Radix Scutellariae, Herba Acalyphae, Fructus Bruceae, Qin Jiu, Radix Tripterygii Wilfordii, Herba Capsellae, each 40-50g of Radix Boehmeriae, the each 30-40g of Crinis Carbonisatus, Testa arachidis hypogaeae, Rhizoma Chuanxiong, Rhizoma Corydalis, Olibanum, Myrrha, catechu, Sanguis Draxonis, Radix Glycyrrhizae 20-30g.

Or, comprise the sterilization group according to mass unit preparation and treatment group, it is characterized in that:

Sterilization group is: Radix Salviae Miltiorrhizae, Radix Scutellariae, Bulbus Allii, Sargassum, Rhizoma Coptidis, Rhizoma Chuanxiong, Cortex Cinnamomi, Flos Caryophylli, each 55-75g of Flos Magnoliae;

Treatment group is: each 45-55g of Herba Houttuyniae, Semen Phaseoli, Radix Platycodonis, Radix Gentianae, Radix Scutellariae, Herba Acalyphae, Fructus Bruceae, Qin Jiu, Radix Tripterygii Wilfordii, Herba Capsellae, each 35-45g of Radix Boehmeriae, the each 35-35g of Crinis Carbonisatus, Testa arachidis hypogaeae, Rhizoma Chuanxiong, Rhizoma Corydalis, Olibanum, Myrrha, catechu, Sanguis Draxonis, Radix Glycyrrhizae 15-25g.

The group that the present invention sterilized is prepared as powder: mixing after each for sterilization group component being pulverized, obtain mixture, soak after 24 hours, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, through ultraviolet radiation disinfection 10 seconds, obtain antibacterial of the present invention.Be used alone sterilization group, be watered and stir, mass ratio is 1:8.

Treatment group of the present invention is prepared as powder: mixing after each for treatment group component being pulverized, obtain mixture, soak after 24 hours, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, through ultraviolet radiation disinfection 10 seconds, obtain treatment group of the present invention, after treatment group is used in sterilization group, use treatment group to be watered to stir, mass ratio is 1:4.

During encapsulation, sterilization group and treatment group encapsulate in two soft capsules of plastics respectively, and are bonded side by side by two soft capsules.

Using method: external, is watered flushing, first rinses by sterilization group, then rinses by treatment group.

Bacteriostatic experiment

1, get clostridium tetani, inoculation anaerobism training base, cultivate 48h under anaerobic condition, normal saline is washed down, standard pipe turbidimetric assay, regulates anaerobe 5 × 10 ⁶cUF/ml

2, screening adopts plate punch method.Standard: bacterial restrain >20mm is high responsive, and bacterial restrain 11-19mm is responsive, and below 10mm is drug resistance.

3, the Antibacterial Activity of group adopts agar dilution.

First group is the effect of the prescription being used alone sterilization group in the present embodiment 1.

Second group is the effect of the prescription being used alone treatment group in the present embodiment 1.

3rd group is the effect that the present embodiment 1 employs after sterilization group and treatment group

4th group is the effect of the prescription of background technology 2014106374963.

5th group is the effect of the prescription of background technology 2015104665494.

6th group is the antibacterial effect of the aqueous solution of metronidazole

Upper table can find, the result of use of first group and the 3rd group is best.But the 3rd group be first group, second group use continuously after effect.At this, then measure first group, second group effect best quality specific concentration.Following table is the growing state of antibacterial at the agar plate of variable concentrations

Model comparative test:

120 rats, from rat lower limb side cutting 2cm length wound, blowing hot-air 12 times in 24 hours, 2 hours once, and each blowing 20 minutes, infected with clostridium tetani after 24 hours, 24 hours again, collect wound transudate, plain agar flat board was cultivated after 24 ~ 48 hours, the irregular bacterium colony of more than diameter 1mm can be formed, close centre, periphery loosens, and like featheriness bacterium colony, easily migrates diffusion in media surface.Blood agar plate has obvious zone of hemolysis.Observe: the muscle not life of wound place, wound does not conform to, and health cold and heat are more done, and health is anti-strong, and locked mouth is not opened, and masticatory atonia, local muscle are felt nervous, pulled pain, hyperreflexia.Tetanus model becomes.

Get tetanus rat model 60, be divided into three groups at random, often organize 20.

A group uses the present invention.

Sterilization group is: Radix Salviae Miltiorrhizae, Radix Scutellariae, Bulbus Allii, Sargassum, Rhizoma Coptidis, Rhizoma Chuanxiong, Cortex Cinnamomi, Flos Caryophylli, each 80g of Flos Magnoliae, mixing after each for sterilization group component is pulverized, obtain mixture, soak after 24 hours, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, through ultraviolet radiation disinfection 10 seconds, obtain antibacterial of the present invention.Be used alone sterilization group, be watered and stir, mass ratio is 1:8.

Treatment group is: Herba Houttuyniae, Semen Phaseoli, the each 60g of Radix Platycodonis, Radix Gentianae, Radix Scutellariae, Herba Acalyphae, Fructus Bruceae, Qin Jiu, Radix Tripterygii Wilfordii, Herba Capsellae, the each 50g of Radix Boehmeriae, Crinis Carbonisatus, Testa arachidis hypogaeae, Rhizoma Chuanxiong, Rhizoma Corydalis, Olibanum, Myrrha, catechu, the each 40g of Sanguis Draxonis, mixing after each for treatment group component is pulverized by Radix Glycyrrhizae 30g, obtain mixture, soak after 24 hours, mixture is joined in the water of 6 ~ 8 times amount and decoct, decoct 2 ~ 4 hours at every turn, decoct 3 times, the complete rear filtration of each decoction, filtrate mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, through ultraviolet radiation disinfection 10 seconds, obtain treatment group of the present invention, after treatment group is used in sterilization group, use treatment group to be watered to stir, mass ratio is 1:4.

Using method: external, is watered flushing, first rinses by sterilization group, then rinses by treatment group.

B group is the effect of the prescription of background technology 2014106374963, water decoction, for oral administration.

C group is the effect of the prescription of background technology 2015104665494, water decoction, for oral administration.

To sum up, the present invention can effectively process wound, suppresses clostridium tetani, avoids infection, avoid wound to worsen, and accelerates healing rate.In addition, the present invention is external, little to human body side effect.

Example 1

Cao, shoulder knife injury, the same day enters to sew up, but does not inject tetanus antitoxin, and after this one week, stiffness of the neck, face spasm, difficulty in opening mouth, had suppuration, microscopic examination clostridium tetani, wound disunion, uses the present invention:

Sterilization group is: Radix Salviae Miltiorrhizae, Radix Scutellariae, Bulbus Allii, Sargassum, Rhizoma Coptidis, Rhizoma Chuanxiong, Cortex Cinnamomi, Flos Caryophylli, each 80g of Flos Magnoliae, mixing after each for sterilization group component is pulverized, obtain mixture, soak after 24 hours, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, through ultraviolet radiation disinfection 10 seconds, obtain antibacterial of the present invention.Be used alone sterilization group, be watered and stir, mass ratio is 1:8.

Treatment group is: Herba Houttuyniae, Semen Phaseoli, the each 60g of Radix Platycodonis, Radix Gentianae, Radix Scutellariae, Herba Acalyphae, Fructus Bruceae, Qin Jiu, Radix Tripterygii Wilfordii, Herba Capsellae, the each 50g of Radix Boehmeriae, Crinis Carbonisatus, Testa arachidis hypogaeae, Rhizoma Chuanxiong, Rhizoma Corydalis, Olibanum, Myrrha, catechu, the each 40g of Sanguis Draxonis, mixing after each for treatment group component is pulverized by Radix Glycyrrhizae 30g, obtain mixture, soak after 24 hours, mixture is joined in the water of 6 ~ 8 times amount and decoct, decoct 2 ~ 4 hours at every turn, decoct 3 times, the complete rear filtration of each decoction, filtrate mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, through ultraviolet radiation disinfection 10 seconds, obtain treatment group of the present invention, after treatment group is used in sterilization group, use treatment group to be watered to stir, mass ratio is 1:4.

Using method: external, is watered flushing, first rinses by sterilization group, then rinses by treatment group.

Effect: detumescence in 3 days, 5 days no pus, incrustation in 8 days, decrustation in 15 days.

Example 2

Lee, arm knife injury, wound is dark, and do not inject tetanus antitoxin after stitching, after this one week, stiffness of the neck, face spasm, difficulty in opening mouth, had suppuration, microscopic examination clostridium tetani, wound disunion, uses the present invention:

Sterilization group is: Radix Salviae Miltiorrhizae, Radix Scutellariae, Bulbus Allii, Sargassum, Rhizoma Coptidis, Rhizoma Chuanxiong, Cortex Cinnamomi, Flos Caryophylli, each 70g of Flos Magnoliae, mixing after each for sterilization group component is pulverized, obtain mixture, soak after 24 hours, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, through ultraviolet radiation disinfection 10 seconds, obtain antibacterial of the present invention.Be used alone sterilization group, be watered and stir, mass ratio is 1:8.

Treatment group is: Herba Houttuyniae, Semen Phaseoli, the each 50g of Radix Platycodonis, Radix Gentianae, Radix Scutellariae, Herba Acalyphae, Fructus Bruceae, Qin Jiu, Radix Tripterygii Wilfordii, Herba Capsellae, the each 40g of Radix Boehmeriae, Crinis Carbonisatus, Testa arachidis hypogaeae, Rhizoma Chuanxiong, Rhizoma Corydalis, Olibanum, Myrrha, catechu, the each 30g of Sanguis Draxonis, mixing after each for treatment group component is pulverized by Radix Glycyrrhizae 20g, obtain mixture, soak after 24 hours, mixture is joined in the water of 6 ~ 8 times amount and decoct, decoct 2 ~ 4 hours at every turn, decoct 3 times, the complete rear filtration of each decoction, filtrate mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, through ultraviolet radiation disinfection 10 seconds, obtain treatment group of the present invention, after treatment group is used in sterilization group, use treatment group to be watered to stir, mass ratio is 1:4.

Using method: external, is watered flushing, first rinses by sterilization group, then rinses by treatment group.

Effect: detumescence in 2 days, 4 days no pus, incrustation in 8 days, decrustation in 15 days.

Example 3

Yuan, foot scratches, and wound is dark, and do not inject tetanus antitoxin after stitching, after this one week, stiffness of the neck, face spasm, difficulty in opening mouth, had suppuration, microscopic examination clostridium tetani, wound disunion, uses the present invention:

Sterilization group is: Radix Salviae Miltiorrhizae, Radix Scutellariae, Bulbus Allii, Sargassum, Rhizoma Coptidis, Rhizoma Chuanxiong, Cortex Cinnamomi, Flos Caryophylli, each 75g of Flos Magnoliae, mixing after each for sterilization group component is pulverized, obtain mixture, soak after 24 hours, mixture is joined in the water of 6 ~ 8 times amount and decoct, each decoction 2 ~ 4 hours, decoct 3 times, the complete rear filtration of each decoction, filtrate is mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, through ultraviolet radiation disinfection 10 seconds, obtain antibacterial of the present invention.Be used alone sterilization group, be watered and stir, mass ratio is 1:8.

Treatment group is: Herba Houttuyniae, Semen Phaseoli, the each 55g of Radix Platycodonis, Radix Gentianae, Radix Scutellariae, Herba Acalyphae, Fructus Bruceae, Qin Jiu, Radix Tripterygii Wilfordii, Herba Capsellae, the each 45g of Radix Boehmeriae, Crinis Carbonisatus, Testa arachidis hypogaeae, Rhizoma Chuanxiong, Rhizoma Corydalis, Olibanum, Myrrha, catechu, the each 35g of Sanguis Draxonis, mixing after each for treatment group component is pulverized by Radix Glycyrrhizae 25g, obtain mixture, soak after 24 hours, mixture is joined in the water of 6 ~ 8 times amount and decoct, decoct 2 ~ 4 hours at every turn, decoct 3 times, the complete rear filtration of each decoction, filtrate mixed, carry out concentrating under reduced pressure and obtain extractum, being joined by extractum relative to the determining alcohol of mixture quality 2 ~ 3 times amount is in the alcoholic solution of 90% ~ 95%, stir and dissolve completely, subsequently 4 DEG C of following hold over night of temperature, filter subsequently, filtrate is carried out concentrating under reduced pressure removing ethanol, the mastic obtained is pulverized as powder, through ultraviolet radiation disinfection 10 seconds, obtain treatment group of the present invention, after treatment group is used in sterilization group, use treatment group to be watered to stir, mass ratio is 1:4.

Using method: external, is watered flushing, first rinses by sterilization group, then rinses by treatment group.

Effect: detumescence in 3 days, 6 days no pus, incrustation in 8 days, decrustation in 16 days.

Therapeutic effect compares:

Screen 180 routine patients in 4 hospitals, before test 1 week, carry out Continuous Observation to this crowd, record symptom and change, be divided into 3 groups at random, often organize 60 people.

First group of prescription using example 1 of the present invention, operates by its using method.

Second group is the effect of the prescription of background technology 2014106374963, and water decoction is for oral administration.

3rd group is the effect of the prescription of background technology 2015104665494, and water decoction is for oral administration.

Curative effect situation criterion: cure: after using this product, indices is replied normal; Effective: after taking and using this product, malaise symptoms makes moderate progress; Invalid: after using this product, malaise symptoms is unchanged.Result is as shown in table 1.

Table 1:

Group	Case load	Efficiently individual quantity	Healing number	Invalid number	Recurrence number	Cure rate	Total effective rate
								First group	60	57	53	3	4	88.3%	95%
Second group	60	36	32	24	4	53.3	60%
								3rd group	60	32	30	28	2	50%	53.3%

With treatment group, flushing drug treatment is carried out to the wound after sterilization operation, with the Herba Houttuyniae of evacuation of pus, Semen Phaseoli, Radix Platycodonis for monarch drug; Treatment group with the Radix Gentianae of bringing down a fever, Radix Scutellariae, the Herba Acalyphae of removing toxic substances, Fructus Bruceae, the Qin Jiu of subduing swelling and relieving pain, Radix Tripterygii Wilfordii, the Herba Capsellae of cooling blood for hemostasis, Radix Boehmeriae are ministerial drug; Anastaltic Crinis Carbonisatus, Testa arachidis hypogaeae, the Rhizoma Chuanxiong of circulation of qi promoting hemostasis and pain-relieving, Rhizoma Corydalis, the Olibanum of granulation promoting pain relieving, Myrrha, catechu, Sanguis Draxonis are adjuvant drug, with Radix Glycyrrhizae for making medicine.

Claims (4)

1. be used for the treatment of a tetanic medicine for external use, comprise the sterilization group according to mass unit preparation and treatment group, it is characterized in that:

Sterilization group is: Radix Salviae Miltiorrhizae, Radix Scutellariae, Bulbus Allii, Sargassum, Rhizoma Coptidis, Rhizoma Chuanxiong, Cortex Cinnamomi, Flos Caryophylli, each 60-80g of Flos Magnoliae;

Treatment group is: each 40-60g of Herba Houttuyniae, Semen Phaseoli, Radix Platycodonis, Radix Gentianae, Radix Scutellariae, Herba Acalyphae, Fructus Bruceae, Qin Jiu, Radix Tripterygii Wilfordii, Herba Capsellae, each 30-50g of Radix Boehmeriae, the each 20-40g of Crinis Carbonisatus, Testa arachidis hypogaeae, Rhizoma Chuanxiong, Rhizoma Corydalis, Olibanum, Myrrha, catechu, Sanguis Draxonis, Radix Glycyrrhizae 10-30g.

2. be used for the treatment of tetanic medicine for external use according to claim 1, comprise the sterilization group according to mass unit preparation and treatment group, it is characterized in that:

Sterilization group is: Radix Salviae Miltiorrhizae, Radix Scutellariae, Bulbus Allii, Sargassum, Rhizoma Coptidis, Rhizoma Chuanxiong, Cortex Cinnamomi, Flos Caryophylli, each 60-70 of Flos Magnoliae;

Treatment group is: each 40-50g of Herba Houttuyniae, Semen Phaseoli, Radix Platycodonis, Radix Gentianae, Radix Scutellariae, Herba Acalyphae, Fructus Bruceae, Qin Jiu, Radix Tripterygii Wilfordii, Herba Capsellae, each 30-40g of Radix Boehmeriae, the each 20-30g of Crinis Carbonisatus, Testa arachidis hypogaeae, Rhizoma Chuanxiong, Rhizoma Corydalis, Olibanum, Myrrha, catechu, Sanguis Draxonis, Radix Glycyrrhizae 10-20g.

3. be used for the treatment of tetanic medicine for external use according to claim 1, comprise the sterilization group according to mass unit preparation and treatment group, it is characterized in that:

Sterilization group is: Radix Salviae Miltiorrhizae, Radix Scutellariae, Bulbus Allii, Sargassum, Rhizoma Coptidis, Rhizoma Chuanxiong, Cortex Cinnamomi, Flos Caryophylli, each 50-80g of Flos Magnoliae;

Treatment group is: each 50-60g of Herba Houttuyniae, Semen Phaseoli, Radix Platycodonis, Radix Gentianae, Radix Scutellariae, Herba Acalyphae, Fructus Bruceae, Qin Jiu, Radix Tripterygii Wilfordii, Herba Capsellae, each 40-50g of Radix Boehmeriae, the each 30-40g of Crinis Carbonisatus, Testa arachidis hypogaeae, Rhizoma Chuanxiong, Rhizoma Corydalis, Olibanum, Myrrha, catechu, Sanguis Draxonis, Radix Glycyrrhizae 20-30g.

4. be used for the treatment of tetanic medicine for external use according to claim 1, comprise the sterilization group according to mass unit preparation and treatment group, it is characterized in that:

Sterilization group is: Radix Salviae Miltiorrhizae, Radix Scutellariae, Bulbus Allii, Sargassum, Rhizoma Coptidis, Rhizoma Chuanxiong, Cortex Cinnamomi, Flos Caryophylli, each 55-75g of Flos Magnoliae;

Treatment group is: each 45-55g of Herba Houttuyniae, Semen Phaseoli, Radix Platycodonis, Radix Gentianae, Radix Scutellariae, Herba Acalyphae, Fructus Bruceae, Qin Jiu, Radix Tripterygii Wilfordii, Herba Capsellae, each 35-45g of Radix Boehmeriae, the each 35-35g of Crinis Carbonisatus, Testa arachidis hypogaeae, Rhizoma Chuanxiong, Rhizoma Corydalis, Olibanum, Myrrha, catechu, Sanguis Draxonis, Radix Glycyrrhizae 15-25g.