CN112401238A - 防治高尿酸血症和痛风的药膳食疗组合物及其制备方法 - Google Patents

防治高尿酸血症和痛风的药膳食疗组合物及其制备方法 Download PDF

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CN112401238A
CN112401238A CN202011329370.1A CN202011329370A CN112401238A CN 112401238 A CN112401238 A CN 112401238A CN 202011329370 A CN202011329370 A CN 202011329370A CN 112401238 A CN112401238 A CN 112401238A
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吴正治
梁少瑜
曾永长
曾嫱
李子雯
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Shenzhen Institute of Gerontology
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Abstract

本发明提供一种防治高尿酸血症和痛风的药膳食疗组合物,由以下重量份的原料制备而成:菊苣1~15份,神仙草1~15份,余甘子1~20份,槐米1~15份,野葛根1~20份,紫苏1~15份,野菊花1~10份,桑叶1~15份,乌梅1~15份,茯苓1~20份,百合1~20份,叶酸0.1~1份,壳寡糖0.1~1.5份,低聚木糖0.5~5份。以及,提供上述防治高尿酸血症和痛风的药膳食疗组合物的制备方法。所述防治高尿酸血症和痛风的药膳食疗组合物疗效明确、作用靶点和药理效应清晰、原料来源广、成本低、制备方法简单,可以多成分、多靶点、多途径、多角度干预痛风与高尿血酸症各个环节,协同防治这种慢性疾病。

Description

防治高尿酸血症和痛风的药膳食疗组合物及其制备方法
技术领域
本发明属于保健品技术领域,具体涉及一种防治高尿酸血症和痛风的药膳食疗组合物及其制备方法。
背景技术
高尿酸血症(hyperruriceemia,HUA)是指在正常嘌呤饮食状态下非同日两次空腹血尿酸水平男性高于420μmol/L、女性高于360μmol/L。尿酸长期升高常导致关节炎性破坏出现痛风和肾功能受损。最新研究显示我国高尿酸血症的患病率为16.85%,高尿酸血症患者已达2.36亿。
目前西医降尿酸药物不良反应大,常伴明显的胃肠道反应、肝肾功能损害、神经毒性及肌肉毒性,严重者出现剥脱性皮炎。
中医治疗本病具有临床疗效确切、安全性高、毒副作用小等优点。中医药被认为对高尿酸、痛风的疗效明确,除了临床方剂外,中成药也被推荐用于高高尿酸痛风的防治,如痛风定片、痛风舒片,复方伸筋胶囊、四妙丸等,但是这些都属于药物类产品,这些药品需要在临床医生或者药师的指导下用药。相关药食同源类产品较少。因此,药食同源降尿酸防治痛风的产品有着广阔的前景。
发明内容
本发明所要解决的技术问题在于克服现有技术之缺陷,提供一种防治高尿酸血症和痛风的药膳食疗组合物及其制备方法。
本发明提供一种防治高尿酸血症和痛风的药膳食疗组合物,由以下重量份的原料制备而成:
菊苣1~15份,
神仙草1~15份,
余甘子1~20份,
槐米1~15份,
野葛根1~20份,
紫苏1~15份,
野菊花1~10份,
桑叶1~15份,
乌梅1~15份,
茯苓1~20份,
百合1~20份,
叶酸0.1~1份,
壳寡糖0.1~1.5份,
低聚木糖0.5~5份。
以及,一种防治高尿酸血症和痛风的药膳食疗组合物的制备方法,其包括如下步骤:
按照上述防治高尿酸血症和痛风的药膳食疗组合物的重量份称取原料,将菊苣、神仙草、余甘子、槐米、野葛根、紫苏、野菊花、桑叶、乌梅、茯苓和百合混合,加10~20倍质量份的水浸泡15~60分钟,加热回流提取0.5~2小时,80~200目过滤,得第一提取液;
向药渣中加10~20倍质量份的水回流提取0.5~2小时,80~200目过滤,得第二提取液;
将第一提取液和第二提取液混合,浓缩,加入叶酸、壳寡糖和低聚木糖,获得所述防治高尿酸血症和痛风的药膳食疗组合物。
本发明的防治高尿酸血症和痛风的药膳食疗组合物,化浊利湿、降酸防痹。防治高尿酸血症与痛风,对尿酸生成的二个关键靶点腺苷脱氨酶(ADA)和黄嘌呤氧化酶(XOD)均有明显抑制活性,并显著增强尿酸排泄核心靶点尿酸转运蛋白的表达。该防治高尿酸血症和痛风的药膳食疗组合物具有疗效明确、使用方便、作用靶点和药理效应清晰、原料来源广、成本低、制备方法简单、患者依从性高等特点,适用人群为高尿酸血症与通风的病患者。
附图说明
图1是本发明实施例提供的防治高尿酸血症和痛风的药膳食疗组合物的中药原料-活性成分-作用靶点关联网络图。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白,以下结合附图及实施例,对本发明进行进一步详细说明。应当理解,此处所描述的具体实施例仅仅用以解释本发明,并不用于限定本发明。
本发明实施例提供一种防治高尿酸血症和痛风的药膳食疗组合物,由以下重量份的原料制备而成:
菊苣1~15份,
神仙草1~15份,
余甘子1~20份,
槐米1~15份,
野葛根1~20份,
紫苏1~15份,
野菊花1~10份,
桑叶1~15份,
乌梅1~15份,
茯苓1~20份,
百合1~20份,
叶酸0.1~1份,
壳寡糖0.1~1.5份,
低聚木糖0.5~5份。
其中,菊苣、神仙草和槐米中的槲皮素等均可抑制炎症因子TNFα和IL-1β等释放、抑制NF-κB、NLRP3炎性小体激活,对抗monosodium urate crystals诱导的啮齿类动物痛风关节炎。野葛根中的葛根素以及山奈提取物可提高抗氧化机能、抑制黄嘌呤氧化酶(xanthine oxidase,直接催化黄嘌呤生成尿酸的酶)、减少尿酸形成、促进尿酸代谢。野菊花中的luteolin-7-O-glucoside,apigenin-7-O-glucoside,木犀草素和芹菜素亦被证明是黄嘌呤氧化酶的抑制剂,IC50分别为23.61,38.80,1.54,1.96μM,提示野菊花可抑制尿酸形成,预防高尿酸血症。分子对接实验进一步证实,诸多中药(如山奈、乌梅、槐米)包含的活性成分山奈酚占据黄嘌呤氧化酶的催化活性位点,竞争性可逆抑制黄嘌呤氧化酶。网络药理学研究提示:该防治高尿酸血症和痛风的药膳食疗组合物能多成分、多靶点、多途径、多角度干预痛风与高尿血酸症各个环节,协同防治这种慢性疾病。该处方全部采用食品级原料,安全有效,生产成本底,预防效果可靠,其可以有效地防治高高尿酸痛风引起的相关症状,是一款主成分清晰,靶点明确的精准药膳产品。
优选地,所述防治高尿酸血症和痛风的药膳食疗组合物由以下重量份的原料制备而成:菊苣8~10份,神仙草5~7份,余甘子8~10份,槐米8~10份,野葛根8~10份,紫苏8~10份,野菊花5~7份,桑叶8~10份,乌梅5~7份,茯苓8~10份,百合8~10份,叶酸0.2~0.4份,壳寡糖0.4~0.6份,低聚木糖0.8~1.2份。更具体地,所述防治高尿酸血症和痛风的药膳食疗组合物由以下重量份的原料制备而成:菊苣9份,神仙草6份,余甘子9份,槐米9份,野葛根9份,紫苏9份,野菊花6份,桑叶9份,乌梅6份,茯苓9份,百合9份,叶酸0.3份,壳寡糖0.5份,低聚木糖1份。该处方全部采用食品级原料,安全有效,生产成本底,预防效果可靠。如图1所示,网络药理学研究初步明确了主治病症-靶点-药效成分作用关系网络,明确了参与作用的生理/病理通路过程,同时,所述防治高尿酸血症和痛风的药膳食疗组合物的成分-靶点-药理作用机制网络研究结果与主治病症衔接一致,符合现代精准医学原则。由于网络药理学关系图空间布局限制,用英文名称或缩写代替,具体中英文对应如表1所示。
表1
英文名 中文名 英文名 中文名
daidzein 黄豆苷元 Vitamin B12 维生素B12
Emodin 大黄素 Xylo-oligosaccharide 低聚木糖
folic acid 叶酸 ABCG2 三磷酸腺苷结合转运蛋白G2
formononetin 芒柄花黄素 JAK2 酪氨酸Janus激酶2
Isorhamnetin 异鼠李素 PPARG 过氧化物酶体增殖剂激活受体γ
kaempferol 山柰酚 SLC22A2 溶质载体家族22
luteolin 木犀草素 STAT3 信号传导蛋白和转录激活物3
Puerarin 葛根素 XDH 黄嘌呤脱氢酶
quercetin 槲皮素
此外,本品成本低,符合产业化生产需要。
本发明实施例还提供上述防治高尿酸血症和痛风的药膳食疗组合物的制备方法,其包括如下步骤:
按照上述防治高尿酸血症和痛风的药膳食疗组合物的重量份称取原料,将菊苣、神仙草、余甘子、槐米、野葛根、紫苏、野菊花、桑叶、乌梅、茯苓和百合混合,加10~20倍质量份的水浸泡15~60分钟,加热回流提取0.5~2小时,80~200目过滤,得第一提取液;
向药渣中加10~20倍质量份的水回流提取0.5~2小时,80~200目过滤,得第二提取液;
将第一提取液和第二提取液混合,浓缩,加入叶酸、壳寡糖和低聚木糖,获得所述防治高尿酸血症和痛风的药膳食疗组合物。
优选地,按照上述防治高尿酸血症和痛风的药膳食疗组合物的重量份称取原料,将菊苣、神仙草、余甘子、槐米、野葛根、紫苏、野菊花、桑叶、乌梅、茯苓和百合混合,加10~20倍质量份的水浸泡20~40分钟,加热回流提取1小时,100~200目过滤,得第一提取液;
向药渣中加10~15倍质量份的水,加热回流提取0.5~2小时,100~200目过滤,得第二提取液。
更具体地,所述防治高尿酸血症和痛风的药膳食疗组合物,两次提取液的混合液减压浓缩至密度约为1.08,得浓缩液备用;浓缩液加入麦芽糊精,搅拌均匀,喷雾干燥(喷嘴进风温度设为150度,出风口温度80度),即得提取物粉末,备用。
取上述喷干粉加入叶酸、壳寡糖和低聚木糖,混合均匀;分装,10g/袋,即得固体饮料。
或者,以上述喷雾干燥的粉末加入叶酸、壳寡糖和低聚木糖,进行制粒,干燥,分装、10g/袋,制备成颗粒剂。
采用喷干粉,加入叶酸、壳寡糖和低聚木糖等适宜的食品原料,进行制粒,干燥,压片;做成适宜的片剂形式即可。
产品的最终形式可以是多种,包括粉剂、颗粒、片剂、蜜丸、膏滋、口服液、糖浆剂等。制备工艺中,干燥方式可以是喷雾干燥、真空干燥、冷冻干燥等;制粒方法可以是干法制粒、湿法制粒、一步制粒等。
采用药学、食品、保健品等相关法规可以接受的方法,均可以对上述防治高尿酸血症和痛风的药膳食疗组合物进行提取、浓缩、干燥或粉碎,进一步加工为产品,保留复方的有效成分,制成适宜的给药形式(包括颗粒剂、粉剂、口服液、片剂等剂型)或者食品形式如压片糖果、餐粉、固体饮料等形式,满足市场对相关产品的需求,均属于本发明保护的范围。
以下通过具体配方和制备工艺的实施例来说明上述防治高尿酸血症和痛风的药膳食疗组合物及其制备方法。
实施例1:
称取菊苣9kg,神仙草6kg,余甘子9kg,槐米9kg,野葛根9kg,紫苏9kg,野菊花6kg,桑叶9kg,乌梅6kg,茯苓9kg,百合9kg,混合,加水15倍浸泡30分钟,加热回流提取1小时,200目过滤,药渣加10倍水回流提取1小时;合并滤液,减压浓缩密度约为1.08,加入麦芽糊精适量,喷雾干燥,即得提取物;加入叶酸0.3kg,壳寡糖0.5kg,低聚木糖1.0kg,混合均匀,上粉末包装机,分装,制成固体饮料,10g/袋。
实施例2:
选择100位高尿酸患者作为保健品每日服用上述防治高尿酸血症和痛风的药膳食疗组合物制备方法制备的固体饮料,每天2~3次;每次取本品一袋,加入100~200毫升热水冲调搅至溶解后,食用。连服两周,有70%以上患者的尿酸有不同程度的降低。
以上所述仅为本发明的较佳实施例而已,并不用以限制本发明,凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等,均应包含在本发明的保护范围之内。

Claims (6)

1.一种防治高尿酸血症和痛风的药膳食疗组合物,其特征在于,所述药膳食疗组合物由以下重量份的原料制备而成:
菊苣1~15份,
神仙草1~15份,
余甘子1~20份,
槐米1~15份,
野葛根1~20份,
紫苏1~15份,
野菊花1~10份,
桑叶1~15份,
乌梅1~15份,
茯苓1~20份,
百合1~20份,
叶酸0.1~1份,
壳寡糖0.1~1.5份,
低聚木糖0.5~5份。
2.如权利要求1所述的防治高尿酸血症和痛风的药膳食疗组合物,其特征在于,所述药膳食疗组合物由以下重量份的原料制备而成:
菊苣8~10份,
神仙草5~7份,
余甘子8~10份,
槐米8~10份,
野葛根8~10份,
紫苏8~10份,
野菊花5~7份,
桑叶8~10份,
乌梅5~7份,
茯苓8~10份,
百合8~10份,
叶酸0.2~0.4份,
壳寡糖0.4~0.6份,
低聚木糖0.8~1.2份。
3.如权利要求2所述的防治高尿酸血症和痛风的药膳食疗组合物,其特征在于,所述药膳食疗组合物由以下重量份的原料制备而成:
菊苣9份,
神仙草6份,
余甘子9份,
槐米9份,
野葛根9份,
紫苏9份,
野菊花6份,
桑叶9份,
乌梅6份,
茯苓9份,
百合9份,
叶酸0.3份,
壳寡糖0.5份,
低聚木糖1份。
4.一种防治高尿酸血症和痛风的药膳食疗组合物的制备方法,其特征在于,包括如下步骤:
按照权利要求1~3任一所述的防治高尿酸血症和痛风的药膳食疗组合物的重量份称取原料,将菊苣、神仙草、余甘子、槐米、野葛根、紫苏、野菊花、桑叶、乌梅、茯苓和百合混合,加10~20倍质量份的水浸泡15~60分钟,加热回流提取0.5~2小时,80~200目过滤,得第一提取液;
向药渣中加10~20倍质量份的水回流提取0.5~2小时,80~200目过滤,得第二提取液;
将第一提取液和第二提取液混合,浓缩,加入叶酸、壳寡糖和低聚木糖,获得所述防治高尿酸血症和痛风的药膳食疗组合物。
5.如权利要求4所述的防治高尿酸血症和痛风的药膳食疗组合物的制备方法,其特征在于,将菊苣、神仙草、余甘子、槐米、野葛根、紫苏、野菊花、桑叶、乌梅、茯苓和百合混合,加12~15倍质量份的水浸泡25~35分钟。
6.如权利要求4所述的防治高尿酸血症和痛风的药膳食疗组合物的制备方法,其特征在于,向药渣中加10~15倍质量份的水。
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