CN112353738A - Moisturizing and whitening composition and application thereof - Google Patents
Moisturizing and whitening composition and application thereof Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61Q19/00—Preparations for care of the skin
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- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention discloses a moisturizing and whitening composition, and belongs to the technical field of cosmetics. The moisturizing and whitening composition disclosed by the invention has the advantages that various synthetic whitening functional components and natural plant components are matched with each other, the components and action mechanisms of the components are comprehensive and clear, and the applicability and safety of the product are not required to be worried; through the synergistic effect of the whitening component and the moisturizing component, the obtained moisturizing and whitening composition is mild in property, convenient to use and remarkable in whitening and moisturizing effects, and can make human skin smooth, transparent and tender and white after long-term use. The invention also provides a preparation method of the moisturizing and whitening composition, which is simple in operation steps and can realize industrial large-scale production. The invention also provides a moisturizing and whitening skin care product containing the moisturizing and whitening composition, and the product has excellent skin moisturizing and whitening effects.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a moisturizing and whitening composition and application thereof.
Background
With the improvement of living standard of people, people pay more attention to self image, and cosmetics become necessities of daily life. Moisturizing is a basic appeal of skin care, and the moisturizing effect is the most basic function of cosmetics, so that the moisturizing cosmetics are claimed to have high market occupation ratio, large demand and wide application.
With the continuous deterioration of environmental conditions and the increase of age, the skin of the face of people is easy to have dark skin color, spots and the like. Especially, urban women have a higher probability of having a problem on the face due to various working pressures, and thus cosmetics having whitening effects are increasingly favored by female consumers. In order to improve the skin condition and make the skin moist and white, the daily skin care process of many women is very complicated. However, some currently sold whitening cosmetics have the problems and defects of single whitening mechanism, unobvious whitening effect, poor formula stability, high irritation and the like, and bring troubles to users.
CN201711312846.9 discloses a moisturizing and whitening composition, which contains the following components in parts by weight: 0.03-4.1 parts of a goldenrod dry cell extract, 0.7-6.9 parts of a rosemary extract, 0.8-7.4 parts of a anoectochilus roxburghii extract, 0.65-8.8 parts of a phoma japonica extract and 1.1-9.7 parts of a sugarcane extract. However, the composition in the product of the prior art is a combination of pure plant extracts, has single efficacy, and does not know whether the addition of other chemical synthesis components affects the applicability and safety of the product.
CN201611154539.8 discloses a whitening and moisturizing composition, a preparation method and a use method thereof. The whitening and moisturizing composition disclosed in this document includes: 2.5-12.5% of tremella heteropolysaccharide, 5-10% of dendrobium officinale extract, 15-50% of mulberry leaf extract, 15-50% of liquorice extract and 15-30% of coix seed powder; the tremella heteropolysaccharide takes alpha- (1-3) mannose as a main chain, mainly comprises 70-93 wt% of neutral total sugar, 6-28 wt% of glucuronic acid and 0.1-3 wt% of binding protein, and has an average molecular weight of 85-160 ten thousand daltons, wherein the molecular weight of more than 6000 daltons accounts for more than 90 wt%. However, the preparation process of the product is complex, and the defect of inconvenient use exists.
Disclosure of Invention
Based on the defects of the prior art, the invention aims to provide the moisturizing and whitening composition, and the composition has the advantages of coordinated matching of all components, comprehensive and clear mechanism of effective components, mild property and convenience in use.
In order to achieve the purpose, the invention adopts the technical scheme that:
the moisturizing and whitening composition comprises the following components in parts by weight: 1-5 parts of xylitol humectant, 0.5-4 parts of nicotinamide, 0.1-2 parts of 3-o-ethyl ascorbic acid, 0.1-0.1 part of nonapeptide-10.001, 0.05-1 part of acetylated sodium hyaluronate and 2-11 parts of plant whitening factor; the plant whitening factor comprises resveratrol, a flower and leaf extract of oriental cherry, a root and bark extract of peony and an extract of Mesona chinensis Benth.
In the moisturizing and whitening composition provided by the invention, the xylitol humectant is a moisturizing component derived from natural plants, can moisturize and rebuild a skin structural system, promotes the increase of the content of GAGS hyaluronic acid and chondroitin sulfate, improves the moisture content of epidermis and dermis of a human body, promotes the synthesis of ceramide, strengthens the barrier effect of the skin, and reduces the moisture loss; the niacinamide is used as a common cosmetic efficacy component, can promote cell vitality and accelerate metabolism and microcirculation of local skin of a human body, and meanwhile, the cosmetic prepared by using the niacinamide as the component can reinforce the skin barrier, improve the skin texture, make the skin smooth and fine, and has the effect of improving wrinkles after being used for a long time; the 3-o-ethyl ascorbic acid is a stable vitamin C derivative, has a wide application range in cosmetics, can play a role in whitening, redox and promoting collagen proliferation, and can also inhibit skin lipid peroxidation; when in use, the nonapeptide-1 can competitively antagonize the combination of the natural ligand melanocyte stimulating hormone (a-MSH) outside the epidermal cells and the melanocortin receptor 1(MC1R) which is the receptor thereof, inhibit the formation of melanin from the source, reduce the pigmentation of the melanin, lighten color spots and have the effects of safely whitening and removing spots. The acetylated sodium hyaluronate can fill the skin to achieve the effect of plumping the skin and make the skin look more transparent; it has effects of resisting oxidation and protecting extracellular matrix, and can be used for moistening and brightening skin for long term to improve skin wrinkle.
In the plant whitening factors in the moisturizing and whitening composition, resveratrol has the effects of removing free radicals, inhibiting tyrosinase activity and promoting collagen production; the oriental cherry flower leaf extract contains isoflavone, prunetin, glycoside thereof, Prunetin, flavonoid, isoquercitrin, Melihotoside and coumarine, and has effects of relieving inflammation, whitening and brightening skin; the main active ingredient of the peony root bark extract is paeonol, which can inhibit tyrosinase activity and has the functions of whitening, removing freckles and the like; the Narcissus tazetta extract can reduce the length of melanocyte dendrite, inhibit synthesis and transport of melanocortin precursor and melanin, and has effect of lightening melanophore. Through the matching and synergistic effect of the four plant whitening factors, the moisturizing and whitening composition can effectively provide the effects of moisturizing, oxidation resistance, wrinkle resistance, color spot inhibition and the like required by human skin.
In the moisturizing and whitening composition provided by the invention, a plurality of synthetic whitening functional components and natural plant components are matched with each other, the components and action mechanisms of the components are comprehensive and clear, and the applicability and safety of the product are not required to be worried; through the synergistic effect of the whitening component and the moisturizing component, the obtained moisturizing and whitening composition is mild in property, convenient to use and remarkable in whitening and moisturizing effects, and can make human skin smooth, transparent and tender and white after long-term use.
Preferably, the plant whitening factor comprises the following components in parts by weight: 0.05-1 part of resveratrol, 0.2-2 parts of a flower and leaf extract of Tokyo cherry, 1-5 parts of a peony root bark extract and 0.5-3 parts of a sea narcissus extract. The components are mutually synergistic and have higher activity under the specific proportion, the skin cannot be influenced by overhigh content of the single component, the effect cannot be poor due to low content of the single component, and the prepared plant whitening factor has good skin moisturizing effect and whitening and brightening effect. More preferably, the plant whitening factor comprises the following components in parts by weight: 0.2 part of resveratrol, 0.5 part of oriental cherry leaf extract, 2.5 parts of peony root bark extract and 1.5 parts of immortal marigold extract. The plant whitening factor obtained in the proportion has a good using effect.
Preferably, the moisturizing and whitening composition comprises the following components in parts by weight: 3 parts of xylitol humectant, 1.2 parts of nicotinamide, 0.5 part of 3-o-ethyl ascorbic acid, 0.1 part of nonapeptide-10.005 parts of acetylated sodium hyaluronate and 4.7 parts of plant whitening factor; 0.2 part of plant whitening factor resveratrol, 0.5 part of oriental cherry leaf extract, 2.5 parts of peony root bark extract and 1.5 parts of Mesona chinensis extract. The synthetic components and the natural plant components have higher synergistic degree under the mixture ratio, and the obtained moisturizing and whitening composition has better moisturizing and whitening effects.
Preferably, the xylitol humectant comprises xylitol glucoside, anhydroxylitol, xylitol, glucose, and water. The components in the xylitol humectant have little irritation to the skin and are safe, and besides the function of conditioning the moisture content of the skin can be provided for a final product, the xylitol humectant can also be used as a thickening agent, so that other components of the moisturizing and whitening composition are fully connected, and the uniformity and the stability of the moisturizing and whitening composition are ensured. More preferably, the xylitol humectant comprises the following components in mass content: 40% xylitol glucoside, 27.5% anhydroxylitol, 15.5% xylitol, 1% glucose and 16% water. The xylitol humectant prepared according to the proportion has more excellent thickening property and skin moisture retention property.
Another object of the present invention is to provide a method for preparing the moisturizing and whitening composition, the method comprising: and (3) mixing and uniformly stirring the xylitol humectant, the nicotinamide, the 3-o-ethyl ascorbic acid, the nonapeptide-1, the acetylated sodium hyaluronate and the plant whitening factors to obtain the moisturizing and whitening composition.
The preparation method of the moisturizing and whitening composition provided by the invention is simple in operation steps, and can realize industrial large-scale production.
Still another object of the present invention is to provide a skin care product comprising the moisturizing and whitening composition.
The moisturizing and whitening skin care product comprises the following components in percentage by mass: 5-15% of a humectant, 3-10% of an emollient, 0.2-2% of a thickener, 0.2-2% of an emulsifier, 0.01-0.5% of a chelating agent, 3.5-24% of the moisturizing and whitening composition, 0.8-2% of a preservative, 0.02-0.5% of an aromatic and the balance of water.
According to the moisturizing and whitening skin care product provided by the invention, the moisturizing and whitening composition is matched with other components, so that the finally obtained product is high in stability and strong in durability, is suitable for consumers with various skin properties, and has excellent skin moisturizing and whitening effects.
Preferably, the moisturizer comprises at least one of glycerin, butylene glycol, sodium hyaluronate, glyceryl polyether-26, propylene glycol, and polyethylene glycol-8.
Preferably, the emollient comprises at least one of dimethicone, caprylic/capric triglyceride, meadowfoam seed oil.
Preferably, the thickener is at least one of sodium acrylate copolymer, lecithin, carbomer and acrylate copolymer.
Preferably, the emulsifier is at least one of cetearyl olive oleate and sorbitan olive oleate.
Preferably, the chelating agent is EDTA-disodium; the aromatic is essence.
Preferably, the preservative comprises at least one of 1, 2-hexanediol, phenoxyethanol, ethylhexylglycerin, p-hydroxyacetophenone, and caprylyl glycol.
The addition of the synthetic components can not only ensure that the prepared moisturizing and whitening skin care product has stable properties, no layering and easy storage and use, but also can be uniformly mixed with the moisturizing and whitening composition to ensure the skin care effect of the product.
Preferably, the moisturizing, whitening and skin-care product comprises the following components in percentage by mass: 2% of glycerin, 3% of butanediol, 1% of sodium hyaluronate, 261% of glyceryl polyether, 2% of polydimethylsiloxane, 2.5% of caprylic/capric triglyceride, 1% of meadowfoam seed oil, 0.3% of a mixture of sodium acrylate copolymer and lecithin, 0.3% of a mixture of cetearyl olive oleate and sorbitan olive oleate, 0.02% of EDTA-disodium, 0.1% of essence, 0.5% of 1, 2-hexanediol, 0.4% of phenoxyethanol, 0.05% of ethylhexyl glycerol, 3% of xylitol humectant, 1.2% of nicotinamide, 0.5% of 3-o-ethyl ascorbic acid, 0. 10.005% of nonapeptide, 0.1% of acetylated sodium hyaluronate, 0.2% of resveratrol, 0.5% of a flower leaf extract of Prunus Tokyo, 2.5% of a root bark extract of peony root, 1.5% of a Haematox extract and the balance of water. The moisturizing and whitening skin care product prepared according to the proportion has good moisturizing, antioxidant, wrinkle removing, anti-pigmentation, whitening and brightening effects, and the skin quality is improved to a high degree.
The invention has the beneficial effects that: the invention provides a moisturizing and whitening composition, wherein a plurality of synthetic whitening functional components and natural plant components are matched with each other, the components and action mechanisms of the components are comprehensive and clear, and the applicability and safety of the product are not required to be worried; through the synergistic effect of the whitening component and the moisturizing component, the obtained moisturizing and whitening composition is mild in property, convenient to use and remarkable in whitening and moisturizing effects, and can make human skin smooth, transparent and tender and white after long-term use. The invention also provides a preparation method of the moisturizing and whitening composition, which is simple in operation steps and can realize industrial large-scale production. The invention also provides a moisturizing and whitening skin care product containing the moisturizing and whitening composition, and the product has excellent skin moisturizing and whitening effects.
Detailed Description
For better illustrating the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to specific examples, which are intended to be understood in detail, but not intended to limit the present invention.
Examples 1 to 4
In the embodiments of the moisturizing and whitening composition, the formula of the moisturizing and whitening skin care product containing the moisturizing and whitening composition in each embodiment is shown in table 1, and the xylitol humectant comprises the following components in percentage by mass: 40% xylitol glucoside, 27.5% anhydroxylitol, 15.5% xylitol, 1% glucose and 16% water. The preparation method of the moisturizing and whitening composition is the same, and the steps are as follows: and (3) mixing and uniformly stirring the xylitol humectant, the nicotinamide, the 3-o-ethyl ascorbic acid, the nonapeptide-1, the acetylated sodium hyaluronate and the plant whitening factors to obtain the moisturizing and whitening composition.
Comparative examples 1 to 6
In the comparative examples of the moisturizing and whitening composition, the moisturizing and whitening skin care products in each comparative example are different from the products in examples 1 to 4 only in the formula, the formula is shown in table 2, the preparation methods of the moisturizing and whitening composition are the same, and the steps are as follows: and (3) mixing and uniformly stirring the xylitol humectant, the nicotinamide, the 3-o-ethyl ascorbic acid, the nonapeptide-1, the acetylated sodium hyaluronate and the plant whitening factors to obtain the moisturizing and whitening composition.
TABLE 1
TABLE 2
Effect example 1
In order to verify the use efficacy of the moisturizing and whitening composition, the skin care products obtained in examples 1 to 4 and comparative examples 1 to 6 were subjected to a moisturizing effect test.
The test method comprises the following steps:
100 volunteers of 20-45 years old are screened, wherein the volunteers are patients without serious system diseases, immunodeficiency or autoimmune diseases, patients without active allergic diseases, previous patients without serious allergic history to cosmetics, patients who have not used hormone medicines and immunosuppressants in the last month, and other subjects who are clinically tested. The volunteers were divided into 10 groups of 10 persons each, and no significant difference was observed between the groups, and the face was selected as the test site, and the test was conducted once before the test (i.e., the skin care product without the moisturizing and whitening composition was used), and the test product was used after cleansing the face every morning and evening, and the moisture content of the stratum corneum and the skin gloss in the test area were measured at 28 days, from the time of sample application. The tested products are skin care products of examples 1-4 and comparative examples 1-6 respectively. The stratum corneum moisture content and Skin gloss were measured using a Skin moisture test probe Cornometer CM825 and a Skin gloss test probe Skin-Glossimeter GL200 (Courage + Khazaka, Germany, 50829Koln, Germany), respectively.
And (4) analyzing result data:
a. calculation of moisture and gloss variation
The blank control value of the test part before use is subtracted from the measured value of the test part after the sample is used to obtain the average value of the variation of the moisture content of the horny layer and the skin glossiness of the test part before and after the product is used, and the calculation formulas are shown as the following formulas (1) and (2).
(1)T＝(Mx-Mo)/10；(2)G＝(Nx-No) 10; wherein: t is the skin moisture variation; mxMeasurement of skin moisture 28 days after use of the product; moSkin moisture placebo measurements; g is the skin glossiness variation; n is a radical ofxIs a measure of skin gloss 28 days after use of the product; n is a radical ofoIs a skin gloss blank measurement.
The test results are shown in table 3.
TABLE 3
| Sample numbering | Mean difference in skin moisture content | Average difference in skin gloss |
| Example 1 | 32.00 | 4.35 |
| Example 2 | 27 | 3.62 |
| Example 3 | 33.00 | 4.51 |
| Example 4 | 28.00 | 3.86 |
| Comparative example 1 | 9.00 | 2.13 |
| Comparative example 2 | 23.00 | 2.02 |
| Comparative example 3 | 27.00 | 2.23 |
| Comparative example 4 | 25.00 | 2.86 |
| Comparative example 5 | 26.00 | 1.77 |
| Comparative example 6 | 37.00 | 2.16 |
The test results in table 3 show that the products obtained in examples 1 to 4 have uniform and significant effects of improving the moisture content and the glossiness of the skin of a user, and have excellent moisturizing, whitening and brightening effects. According to the comparison of the performances of the products in the examples and the comparative products, all synthetic components (such as xylitol humectant, sodium hyaluronate for acetylation, and the like) and natural plant components (such as resveratrol and oriental cherry leaf extract, and the like) are indispensable, and the finally prepared products have good moisturizing and whitening effects only if all the components are matched with each other for synergistic interaction.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The moisturizing and whitening composition is characterized by comprising the following components in parts by weight: 1-5 parts of xylitol humectant, 0.5-4 parts of nicotinamide, 0.1-2 parts of 3-o-ethyl ascorbic acid, 0.1-0.1 part of nonapeptide-10.001, 0.05-1 part of acetylated sodium hyaluronate and 2-11 parts of plant whitening factor; the plant whitening factor comprises resveratrol, a flower and leaf extract of oriental cherry, a root and bark extract of peony and an extract of Mesona chinensis Benth.
2. The moisturizing and whitening composition of claim 1, wherein the plant whitening factor comprises the following components in parts by weight: 0.05-1 part of resveratrol, 0.2-2 parts of a flower and leaf extract of Tokyo cherry, 1-5 parts of a peony root bark extract and 0.5-3 parts of a sea narcissus extract.
3. The moisturizing and whitening composition of claim 2, wherein the plant whitening factor comprises the following components in parts by weight: 0.2 part of resveratrol, 0.5 part of oriental cherry leaf extract, 2.5 parts of peony root bark extract and 1.5 parts of immortal marigold extract.
4. The moisturizing and whitening composition of claim 3, comprising the following components in parts by weight: 3 parts of xylitol humectant, 1.2 parts of nicotinamide, 0.5 part of 3-o-ethyl ascorbic acid, 0.1 part of nonapeptide-10.005 parts of acetylated sodium hyaluronate and 4.7 parts of plant whitening factor; 0.2 part of plant whitening factor resveratrol, 0.5 part of oriental cherry leaf extract, 2.5 parts of peony root bark extract and 1.5 parts of Mesona chinensis extract.
5. The moisturizing and whitening composition of claim 1, wherein the xylitol humectant comprises xylitol glucoside, anhydroxylitol, xylitol, glucose, and water.
6. The method for preparing the moisturizing and whitening composition according to any one of claims 1 to 5, wherein the moisturizing and whitening composition is obtained by uniformly mixing and stirring the xylitol humectant, the nicotinamide, the 3-o-ethyl ascorbic acid, the nonapeptide-1, the sodium hyaluronate acylate and the plant whitening factor.
7. The moisturizing and whitening skin care product is characterized by comprising the following components in percentage by mass: 5 to 15% of a moisturizing agent, 3 to 10% of an emollient, 0.2 to 2% of a thickener, 0.2 to 2% of an emulsifier, 0.01 to 0.5% of a chelating agent, 3.5 to 24% of the moisturizing and whitening composition according to any one of claims 1 to 5, 0.8 to 2% of a preservative, 0.02 to 0.5% of a fragrance, and the balance of water.
8. The moisturizing, whitening and skin-care product of claim 7, wherein the moisturizer comprises at least one of glycerin, butylene glycol, sodium hyaluronate, glyceryl polyether-26, propylene glycol, polyethylene glycol-8; the emollient comprises at least one of polydimethylsiloxane, caprylic/capric triglyceride, and meadowfoam seed oil.
9. The moisturizing and whitening skin care product of claim 7, wherein the thickener is at least one of sodium acrylate copolymer, lecithin, carbomer, and acrylic acid copolymer; the emulsifier is at least one of cetearyl olive oleate and sorbitan olive oleate; the chelating agent is EDTA-disodium; the aromatic is essence; the antiseptic comprises at least one of 1, 2-hexanediol, phenoxyethanol, ethylhexyl glycerol, p-hydroxyacetophenone, and caprylyl glycol.
10. The moisturizing and whitening skin care product of claim 7, comprising the following components in mass content: 2% of glycerin, 3% of butanediol, 1% of sodium hyaluronate, 261% of glyceryl polyether, 2% of polydimethylsiloxane, 2.5% of caprylic/capric triglyceride, 1% of meadowfoam seed oil, 0.3% of a mixture of sodium acrylate copolymer and lecithin, 0.3% of a mixture of cetearyl olive oleate and sorbitan olive oleate, 0.02% of EDTA-disodium, 0.1% of essence, 0.5% of 1, 2-hexanediol, 0.4% of phenoxyethanol, 0.05% of ethylhexyl glycerol, 3% of xylitol humectant, 1.2% of nicotinamide, 0.5% of 3-o-ethyl ascorbic acid, 0. 10.005% of nonapeptide, 0.1% of acetylated sodium hyaluronate, 0.2% of resveratrol, 0.5% of a flower leaf extract of Prunus Tokyo, 2.5% of a root bark extract of peony root, 1.5% of a Haematox extract and the balance of water.
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Application publication date: 20210212 |