CN112326982B - Full-automatic sample injection blood cell analysis measuring device and test tube type determining method - Google Patents
Full-automatic sample injection blood cell analysis measuring device and test tube type determining method Download PDFInfo
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- CN112326982B CN112326982B CN202011217859.XA CN202011217859A CN112326982B CN 112326982 B CN112326982 B CN 112326982B CN 202011217859 A CN202011217859 A CN 202011217859A CN 112326982 B CN112326982 B CN 112326982B
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- 238000012360 testing method Methods 0.000 title claims abstract description 317
- 238000004458 analytical method Methods 0.000 title claims abstract description 64
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- 210000000601 blood cell Anatomy 0.000 title claims abstract description 32
- 238000002347 injection Methods 0.000 title claims abstract description 29
- 239000007924 injection Substances 0.000 title claims abstract description 29
- 238000009534 blood test Methods 0.000 claims abstract description 137
- 210000005259 peripheral blood Anatomy 0.000 claims abstract description 130
- 239000011886 peripheral blood Substances 0.000 claims abstract description 130
- 238000002156 mixing Methods 0.000 claims abstract description 116
- 210000004369 blood Anatomy 0.000 claims abstract description 72
- 239000008280 blood Substances 0.000 claims abstract description 72
- 238000005259 measurement Methods 0.000 claims abstract description 35
- 238000005070 sampling Methods 0.000 claims abstract description 28
- 230000007246 mechanism Effects 0.000 claims description 77
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1048—General features of the devices using the transfer device for another function
- G01N2035/1051—General features of the devices using the transfer device for another function for transporting containers, e.g. retained by friction
Abstract
The invention discloses a method and a device for analyzing and measuring full-automatic sample injection blood cells, wherein the method comprises the following steps: in the process of transversely feeding the test tube rack by the sample loading platform, determining the loading condition of the test tubes on the test tube rack; in the case of determining that the test tube rack is loaded with test tubes, determining the test tube type, wherein the test tube type includes a venous blood test tube and a peripheral blood test tube; determining a mixing mode according to the type of the test tube, and performing mixing operation on blood in the test tube by adopting the determined mixing mode; when the test tube rack is fed to the sample sucking position, determining the descending height according to the determined test tube type, and executing descending action corresponding to the determined descending height by the sampling needle and sucking a sample; and (3) carrying out analysis measurement on the sucked sample, feeding the test tube rack to an unloading position to unload and withdraw the test tube rack to an unloading platform after the analysis measurement is completed, and outputting an analysis measurement result of the sucked sample. The device is used for realizing the method. The invention has high automation degree and high efficiency, and reduces the labor intensity of clinical staff.
Description
Technical Field
The invention belongs to the technical field of blood cell analysis, and particularly relates to a full-automatic sample injection blood cell analysis and measurement method and device and a test tube type determination method.
Background
The existing full-automatic sample injection blood cell analysis and measurement device is only suitable for venous blood, but for peripheral blood, the corresponding full-automatic sample injection blood cell analysis and measurement device does not exist at present because of the small blood sampling amount. Because the vein blood mixing device arranged in the existing blood cell analyzer is not suitable for mixing peripheral blood, an operator is required to manually mix the peripheral blood at the beginning, then a test tube filled with the mixed peripheral blood sample is held under a sampling needle of the blood cell analyzer, the sampling needle sucks the mixed peripheral blood sample into the blood cell analyzer for detection and analysis, and the blood cell analyzer under the condition can only manually sample the peripheral blood. The efficiency of the manual sample injection mode is low, so that a device for realizing automatic sample injection to a certain extent appears on the market, when the device is used, a test tube is placed on a test tube rack, a blood cell analyzer can automatically operate the test tube on the whole test tube rack, and an operator only needs to place the test tube on the test tube rack without lifting the test tube to the position below a sampling needle; but need the blood cell analyzer to throw the diluent into the test tube first, then operating personnel still need take out the test-tube rack from the blood cell analyzer, add the peripheral blood sample to the test tube that has beaten the diluent again, then put back into the blood cell analyzer, inhale by the blood cell analyzer and vomit the misce bene, then carry out subsequent detection operation automatically. The device has realized the autoinjection to a certain extent, but in the middle of still need manual operation, after the blood cell analyzer beaten the diluent in the test tube, need the operator to take out the test tube, again the artifical blood sample of adding peripheral blood to the test tube inside. And venous blood and peripheral blood cannot be automatically distinguished, and the automatic sampling efficiency still needs to be improved.
Disclosure of Invention
The invention aims to provide a full-automatic sample injection blood cell analysis and measurement method and device, which can automatically distinguish venous blood from peripheral blood and automatically sample injection and detection the venous blood and the peripheral blood.
To achieve the object of the present invention, an embodiment of the present invention provides a test tube type determining method of determining a test tube type of a test tube loaded in a test tube rack by a test tube detecting unit, wherein the test tube type includes a venous blood test tube and a peripheral blood test tube, and a bottom thickness of the peripheral blood test tube is greater than a bottom thickness of the venous blood test tube; the method comprises the following steps:
emitting detection light to a lower region of the cuvette;
Whether the cuvette is a venous or peripheral blood cuvette is determined by detecting whether the lower region of the cuvette is transparent.
Optionally, in an embodiment, the tube detection unit is an optical correlation coupler, and the peripheral blood tube is transparent or semitransparent corresponding to a tube body region of the optical correlation coupler.
Optionally, in one embodiment, the peripheral blood test tube includes a tube body, the tube body includes an outer tube body and an inner tube body, a tube body bottom of the inner tube body is located in a middle region of the outer tube body, and a lower region of the outer tube body is light permeable.
Optionally, in one embodiment, the peripheral blood test tube further includes a cap, and the whole or the middle of the cap is made of rubber.
Optionally, in one embodiment, the bottom of the inner tube body is provided with a tapered rounded bottom.
Optionally, in one embodiment, the outer tube body is a skirt that extends above the taper of the bottom of the inner tube body downward by a certain length along the height direction of the tube body.
Optionally, in one embodiment, the skirt is transparent or translucent near the bottom region.
In order to achieve the purpose of the invention, the embodiment of the invention provides a full-automatic sample injection blood cell analysis and measurement method, which comprises the following steps:
In the process of transversely feeding the test tube rack by the sample loading platform, determining the loading condition of the test tubes on the test tube rack;
in the case of determining that the test tube rack is loaded with test tubes, determining the test tube types of the test tubes loaded in the test tube rack, wherein the test tube types comprise venous blood test tubes and peripheral blood test tubes;
Determining a corresponding mixing mode according to the type of the test tube, and adopting the determined mixing mode to perform mixing operation on blood in the test tube;
when the test tube rack is fed to the sample sucking position, determining the descending height according to the determined test tube type, and executing descending action corresponding to the determined descending height by the sampling needle and sucking a sample;
and (3) carrying out analysis measurement on the sucked sample, feeding the test tube rack to an unloading position to unload and withdraw the test tube rack to an unloading platform after the analysis measurement is completed, and outputting an analysis measurement result of the sucked sample.
Optionally, in one embodiment, the bottom thickness of the peripheral blood tube is greater than the bottom thickness of the venous blood tube, the bottom of the peripheral blood tube being light permeable.
Optionally, in one embodiment, the peripheral blood test tube includes an outer tube body and an inner tube body, a tube bottom of the inner tube body is located in a middle region of the outer tube body, and a lower region of the outer tube body is light permeable.
Optionally, in an embodiment, the determining a corresponding blending manner according to the test tube type, and blending the blood in the test tube by adopting the determined blending manner, further includes:
in the case where the test tube type is a peripheral blood test tube, a peripheral blood test tube homogenization mechanism is used to perform a homogenization operation on the blood sample in the test tube.
Optionally, in one embodiment, the homogenizing operation of the blood sample in the test tube by using the peripheral blood test tube homogenizing mechanism further includes:
and placing the test tube in a through test tube bin of a peripheral blood test tube mixing mechanism, so that the bottom of the test tube is abutted with a test tube support of a peripheral blood test tube mixing device.
Optionally, in one embodiment, after the placing the test tube in the through tube bin of the peripheral blood test tube blending mechanism and making the bottom of the test tube abut against the test tube holder of the peripheral blood test tube blending mechanism, the method further includes:
Under the bottom of test tube with the test tube support butt of peripheral blood test tube blending mechanism, peripheral blood test tube blending device's brushless motor drives eccentric block and rotates, and then drives the test tube support of test tube butt produces vibrations, causes the peripheral blood test tube rotation type swing and vibrations in the through-tube storehouse to realize the mixing of in vitro blood sample.
Optionally, in an embodiment, the determining a corresponding blending manner according to the test tube type, and blending the blood in the test tube by adopting the determined blending manner, further includes:
in the case of the type of tube being a venous blood tube, the tube gripping jaw grips the tube from the tube rack and moves over the tube rack, performing the back and forth inversion of the mixing of the blood sample.
Optionally, in an embodiment, in a case that the test tube type is a venous blood test tube, a rotation speed parameter corresponding to the venous blood test tube is determined, and a brushless motor of the peripheral blood test tube mixing mechanism adopts the determined rotation speed parameter to perform a mixing operation on the blood sample in the test tube.
In addition, the embodiment of the invention also provides a full-automatic sample injection blood cell analysis and measurement device, which comprises a control unit, a sample analysis device, a venous blood test tube mixing mechanism, a peripheral blood test tube mixing mechanism, an unloading and withdrawing platform mechanism, a sampling needle, a sample injection loading platform and a test tube detection unit, wherein the sample analysis device is connected with the control unit, and the control unit is used for controlling the sample analysis device to execute corresponding operation by sending a control instruction;
the sample injection loading platform is used for placing a test tube rack and feeding the test tube rack to the sample analysis mechanism so that the sample analysis mechanism can perform sample analysis measurement on blood samples in test tubes on the test tube rack;
The test tube detection unit is used for detecting the loading condition of test tubes on the test tube rack and the types of the test tubes;
the sampling needle is used for executing descending actions corresponding to the descending height according to the descending height determined by the control unit and sucking samples for the sample analysis device to carry out sample analysis measurement;
the venous blood test tube mixing mechanism and/or the peripheral blood test tube mixing mechanism are used for carrying out mixing operation on blood samples in test tubes on the test tube rack;
the unloading and exiting platform mechanism is used for unloading and exiting the test tube rack;
the test tube detection unit emits detection light to a lower region of the test tube;
Whether the cuvette is a venous or peripheral blood cuvette is determined by detecting whether the lower region of the cuvette is transparent.
Optionally, in an embodiment, the test tube detection unit is an optical coupler, and may be disposed at a mixing position on the sample loading platform or any working position before the mixing position.
Optionally, in one embodiment, a tube claw is disposed on the venous blood tube mixing mechanism, and the tube claw is used for clamping a test tube from a test tube rack and moving to a position above the test tube rack, so that the back and forth inversion is implemented to mix the blood sample.
Optionally, in one embodiment, the peripheral blood test tube homogenizing mechanism comprises a feeding mechanism, at least three horizontal supports, a flexible column, a through test tube bin, a test tube holder with a concave curved surface, a brushless motor and an eccentric block
Optionally, in one embodiment, the brushless motor is located on a second horizontal support, the test tube holder is located on the second horizontal support, and the through test tube cartridge is located on a third horizontal support.
Optionally, in one embodiment, one end of the flexible column is connected to the first horizontal support, and the other end is connected to the second horizontal support.
The method and the device for implementing the embodiment of the invention have the following beneficial effects:
The invention provides a full-automatic sample injection blood cell analysis and measurement method and device, which realize a simpler operation mode of peripheral blood whole blood detection, firstly do not need the external pre-dilution of diluent, secondly do not have strict quantitative requirement influence on a measurement sample, and only need to meet the minimum test dosage requirement, like the measurement mode of venous blood. Meanwhile, the method and the device can automatically identify the types of the venous blood sample collecting test tube and the peripheral blood sample collecting test tube through the detection unit, implement the corresponding blood mixing mode according to the test tube, control the sampling needle to automatically sample and analyze according to different test tube types, and finally output analysis and measurement results. The method and the device provided by the embodiment of the invention have high degree of automation, release the labor intensity of clinical staff and improve the efficiency of blood sample injection and detection.
In order to make the above objects, features and advantages of the present invention more comprehensible, preferred embodiments accompanied with figures are described in detail below.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some embodiments of the present invention and should not be considered as limiting the scope, and other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a fully automated blood cell analysis measuring apparatus according to one embodiment;
FIG. 2 is a schematic perspective view of a fully automated blood cell analysis measurement device according to an embodiment of the present invention;
FIG. 3 is a flow chart of a method for analyzing and measuring fully automated blood cells in one embodiment;
FIG. 4 is a schematic diagram of a peripheral blood test tube according to an embodiment of the present invention;
FIG. 5 is a schematic view showing the structure and effect of a test tube rack after loading venous blood test tubes and/or peripheral blood test tubes according to an embodiment of the present invention;
FIG. 6 is a schematic view showing the structure and effect of a test tube rack after loading venous blood test tubes and/or peripheral blood test tubes according to an embodiment of the present invention;
FIG. 7 is a partial schematic view of the structure of the device with the sampling needle at the automatic sampling position according to the embodiment of the present invention;
FIG. 8 is a schematic diagram of a peripheral blood test tube blending mechanism according to an embodiment of the present invention;
FIG. 9 is a schematic flow chart of a mixing operation for test tubes in an embodiment of the present invention;
FIG. 10 is a schematic view of the tube gripping jaw and peripheral blood tube blending mechanism of an embodiment of the present invention in a certain mated position.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the invention. The components of the embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the invention, as presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be made by a person skilled in the art without making any inventive effort, are intended to fall within the scope of the present invention.
In the description of the present invention, it should be noted that the directions or positional relationships indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "inner", "outer", etc. are directions or positional relationships based on the drawings, are merely for convenience of describing the present invention and simplifying the description, and do not indicate or imply that the apparatus or element to be referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
In this embodiment, a method and a device for analyzing and measuring fully-automatic sample-injection blood cells are provided, which can automatically distinguish venous blood from peripheral blood and automatically sample-injection detect venous blood and peripheral blood.
Specifically, in one embodiment, as shown in fig. 1, a full-automatic sample injection blood cell analysis and measurement device is provided, which comprises a control unit 100, and further comprises a sample analysis device 1001 connected with the control unit 100 and controlled by the control unit to perform corresponding operations by sending control instructions, a venous blood test tube mixing mechanism 200, a peripheral blood test tube mixing mechanism 300, an unloading exit platform mechanism 2, a sampling needle 7, a sample injection loading platform 6 and a test tube detection unit 1002;
wherein,
The sample injection loading platform is used for placing a test tube rack and feeding the test tube rack to the sample analysis device so that the sample analysis device can perform sample analysis measurement on blood samples in test tubes on the test tube rack;
The test tube detection unit is used for detecting the loading condition of test tubes on the test tube rack and the types of the test tubes;
the sampling needle is used for executing descending actions corresponding to the descending height according to the descending height determined by the control unit and sucking samples for the sample analysis device to carry out sample analysis measurement;
the venous blood test tube mixing mechanism and/or the peripheral blood test tube mixing mechanism are used for carrying out mixing operation on blood samples in test tubes on the test tube rack;
The unloading and exiting platform mechanism is used for unloading and exiting the test tube rack.
Specifically, the test tube detection unit is used for detecting the loading condition of the test tubes in the test tube rack and detecting the types of the test tubes corresponding to the loaded test tubes. The test tube detection unit detects and judges the type of the blood sample test tube in the test tube rack, namely the blood sample test tube in the test tube rack is a venous blood test tube or a peripheral blood test tube, according to the detection result of the test tube detection unit, the control unit correspondingly carries out the mixing of a venous blood test tube mixing mechanism or the mixing of a peripheral blood test tube mixing mechanism on the test tube with respect to the test tubes of different test tube types identified on the test tube rack, and controls the sampling needle to descend to different depths to absorb the blood sample in the test tube so as to enable the sample analyzer to carry out sample analysis measurement.
For example, the fully automated blood cell analysis measurement device may be based on a physical device as shown in fig. 2.
The embodiment of the invention also provides a full-automatic sample injection blood cell analysis and measurement method, as shown in fig. 3, comprising the following steps:
step S1: and determining the loading condition of the test tube on the test tube rack in the process of transversely feeding the test tube rack by the sample loading platform.
Whether or not the test tube rack is loaded with test tubes is detected by the test tube detecting unit, and the step is performed with the sample loading platform feeding the test tube rack laterally. That is, the execution of the subsequent steps is performed only in the case where test tubes are loaded on the test tube rack, so that unnecessary program waste is avoided.
In a specific embodiment, the test tube detection unit is a pair of optical couplers, and under the condition that whether the test tube is transversely fed through the test tube or not is detected by the optical couplers, if the test tube is detected by the optical couplers, a shielding signal is generated, whether the test tube exists in the test tube rack is judged, otherwise, the test tube rack is determined that the test tube is not loaded.
Step S2: in the case of determining that the test tube rack is loaded with test tubes, the test tube type of the test tubes loaded in the test tube rack is determined, wherein the test tube type includes a venous blood test tube and a peripheral blood test tube.
In the case where a test tube is loaded on a test tube rack, it is necessary to analyze a blood sample in the loaded test tube. In this embodiment, there may be two types of test tubes in the tube rack, one is a normal venous blood test tube, one is a special peripheral blood test tube, and different test tubes correspond to different subsequent operation steps. Therefore, the type of test tube needs to be resolved. Specifically, the test tube type of the test tube loaded in the test tube rack is detected by the test tube detecting unit, wherein the test tube type includes a venous blood test tube and a peripheral blood test tube.
In an alternative embodiment, the bottom thickness of the peripheral blood tube is greater than the bottom thickness of the venous blood tube, wherein the bottom thickness of the tube is the amount of separation between the bottom of the outside of the tube and the bottom of the tube lumen (the bottom of the tube lumen that can hold a blood sample). For example, the bottom of the tube cavity of a peripheral blood tube is located in the middle of the tube, and its bottom thickness is half of the entire height of the tube, while the bottom thickness of a venous blood tube is a common tube wall thickness, which is negligible to the entire height of the tube. Generally, the test tube is made of glass or PP, that is, the portion corresponding to the thickness of the bottom of the tube is transparent to light, and is transparent to light regardless of whether the blood sample is contained in the inner cavity of the test tube.
In the case of a blood sample, the lower region of the test tube corresponding to the bottom thickness of the peripheral blood test tube is light-permeable, and the venous blood test tube has a negligible light-permeable region of the bottom because of the small bottom thickness, and thus, in the case of a blood sample, the lower region of the test tube is light-impermeable, that is, the test tube detection unit can determine which test tube is by detecting whether or not the light-permeable feature of the lower region of the test tube.
In another alternative embodiment, as shown in FIG. 4, the peripheral blood test tube includes an outer tube and an inner tube, the bottom of the tube of the inner tube being located in a central region of the outer tube, and the lower region of the outer tube being light permeable.
As shown in fig. 4, the peripheral blood test tube includes a tube body 11 and a tube cap 12; the whole or the middle part of the tube cap 12 is made of rubber so that the sampling needle can penetrate through; the tube body 11 comprises an inner tube body and an outer tube body, wherein the bottom of the inner tube body is provided with a taper round bottom so as to sample the depth of the needle immersed in the blood sample; the outer tube body is a skirt edge 111 which is formed by extending a certain length downwards along the height direction of the tube body above the taper of the bottom of the inner tube body, so that the tip blood collection tube can be placed in a test tube rack to be suitable for clamping and placing test tube clamping jaws, and the test tube rack does not need to be changed; the skirt 111 is in a transparent or semitransparent state near the bottom, and does not block the detection light of the vacuum blood collection tube. Specifically, as shown in fig. 5 and 6, fig. 5 and 6 show the case where the test tube rack is loaded with the venous blood test tube and the peripheral blood test tube, wherein as shown in fig. 5, the number 011 corresponds to the blood sample in the venous blood test tube, the number 021 corresponds to the blood sample in the peripheral blood test tube, and as shown in fig. 6, the test tube rack 5 is loaded with the number 010 corresponds to the venous blood test tube and the number 020 corresponds to the peripheral blood test tube.
In another alternative embodiment, the cuvette detection unit is a photoelectric sensor, which may be, for example, a pair of optocouplers, by which the bottom or lower area of the cuvette is determined to be detected, and the type of cuvette is determined based on the photoelectric information received by the opposite optocoupler. In this embodiment, the test tube detection unit for determining the test tube type may be disposed at the mixing position on the sample loading platform or at any one of the working positions before the mixing position, that is, the test tube type is detected before the mixing operation is performed.
Optionally, the test tube detection unit selects an optical correlation coupler, as shown in fig. 7, where a first test tube detection unit for detecting whether a test tube is loaded on a test tube rack is the optical correlation coupler 8, and is disposed on the venous blood test tube mixing mechanism, and a second test tube detection unit for detecting a test tube type is the optical correlation coupler 10, and is disposed on the peripheral blood test tube mixing mechanism.
That is, when the test tube rack is transversely fed to a preset working position, the test tube detection unit judges that the test tube is a trace peripheral blood test tube if the test tube detection correlation optocoupler is not shielded; if the test tube detection correlation optocoupler is shielded, the venous blood test tube is judged. Specifically, the method of the embodiment of the invention realizes the detection of two test tube types, namely a venous blood test tube and a peripheral blood test tube by newly adding the high and low level of the correlation optocoupler arranged in the blood sample area at the bottom of the test tube and combining the test tube to judge whether the test tube exists or not; the peripheral blood test tube is in a transparent or semitransparent state corresponding to the tube body area of the newly-added correlation optocoupler.
Step S3: and determining a corresponding mixing mode according to the type of the test tube, and adopting the determined mixing mode to carry out mixing operation on blood in the test tube.
In this embodiment, the venous blood test tube and the peripheral blood test tube are corresponding to different mixing modes, and the amounts and positions of the blood samples therein are different, so that it is necessary to determine the mixing mode corresponding to the type of the test tube to perform the mixing operation on the blood in the test tube, so as to improve the effective rate and accuracy of subsequent sample suction and analysis measurement.
Specifically, in the case where the test tube type is a venous blood test tube, a general mixing operation corresponding to the venous blood test tube is adopted for the mixing operation. For example, the test tube gripper 9 grips a test tube from a test tube rack and moves over the test tube rack, and the mixing of the blood sample is performed upside down.
In the case where the test tube type is a peripheral blood test tube, it is necessary to perform the homogenization operation by adopting a homogenization operation corresponding to the peripheral blood type. Specifically, a peripheral blood tube homogenization mechanism is used to perform a homogenization operation on the blood sample in the tube. The inside of tip blood test tube blending mechanism is provided with and link up test tube storehouse, test tube support, brushless motor, eccentric block, at the in-process that carries out blending operation, control will the test tube is placed in the test tube storehouse that link up of tip blood test tube blending mechanism, makes the bottom of test tube and the test tube support butt of tip blood test tube blending device to make the effect of the blending operation in later stage best. Under the bottom of test tube with the test tube support butt of peripheral blood test tube blending mechanism, peripheral blood test tube blending device's brushless motor drives eccentric block and rotates, and then drives the test tube support of test tube butt produces vibrations, causes the peripheral blood test tube rotation type swing and vibrations in the through-tube storehouse to realize the mixing of in vitro blood sample.
In another alternative embodiment, the mixing mechanism for mixing venous blood test tubes and peripheral blood may be provided as one and the same mechanism, for example, both peripheral blood test tube mixing mechanisms, in order to save space in the apparatus. Specifically, in this embodiment, in the case where the test tube type is a venous blood test tube, a rotation speed parameter corresponding to the venous blood test tube is determined, and a brushless motor of the peripheral blood test tube mixing mechanism performs a mixing operation on a blood sample in the test tube by using the determined rotation speed parameter. That is, different mixing parameters (for example, rotational speed parameters of the brushless motor) are adopted for different types of test tubes for the mixing operation.
As shown in FIG. 8, the sample-sucking needle mechanism including the sampling needle 7 is shown by a venous blood tube mixing mechanism at 200, a peripheral blood tube mixing mechanism at 300, and a sample-sucking needle mechanism at 400.
Step S4: when the test tube rack is fed to the sample sucking position, determining the descending height according to the determined test tube type, and executing the descending action corresponding to the determined descending height by the sampling needle and sucking the sample.
As previously mentioned, because of the different tube types (tube bottom height) and the different blood volumes in the test tubes, the heights of the blood samples in the different tube types are different, and therefore, the sampling needle also needs to use different heights when sucking the sample, and if the same height is used, the sample cannot be sucked or the sucked sample is insufficient in some cases. Therefore, in this embodiment, when the test tube rack is fed to the sample sucking position, the corresponding position, that is, the corresponding descent height, of the sampling needle in the process of sucking the sample is determined according to the test tube type, and then the sampling needle is controlled to execute the descent motion corresponding to the determined descent height, and then the operation of sucking the sample is performed, so that the success rate of sucking the sample is improved, and the effectiveness of subsequent sample analysis is improved.
Step S5: and (3) carrying out analysis measurement on the sucked sample, feeding the test tube rack to an unloading position to unload and withdraw the test tube rack to an unloading platform after the analysis measurement is completed, and outputting an analysis measurement result of the sucked sample.
In the step, the sample analysis mechanism performs analysis measurement on the sample sucked by the sampling needle, and outputs a corresponding analysis measurement result for use after the analysis measurement is completed; and, after the analytical measurement is completed, the test tubes on the test tube rack no longer need to be operated, in which case the test tubes thereon need to be unloaded, that is, the test tube rack is controlled to be fed to an unloading position to exit to an unloading platform to complete the process of automatic sample feeding and analytical measurement.
In the embodiment of the invention, specifically, after the state and the type of the test tube are identified, for example, when the peripheral blood test tube is identified, a test tube clamping jaw on a venous blood test tube mixing mechanism firstly carries out horizontal feeding to a proper position in the direction of the test tube from a ready position of the test tube clamping jaw so as to clamp the peripheral blood test tube; and then moved axially upward along the tube to a suitable height to ensure that the test tube is lifted off the tube rack and lifted to the space between the bottom of the test tube and the top surface of the tube rack allows for horizontal feed insertion of the peripheral blood tube mixing mechanism. That is, the venous blood test tube mixing mechanism is provided with a test tube claw for holding the test tube on the test tube rack to move the test tube. In the embodiment of the invention, after the state and the type of the test tube are identified, for example, when the peripheral blood test tube is identified, the test tube clamping jaw 9 on the venous blood test tube mixing mechanism firstly carries out horizontal feeding to a proper position in the test tube direction from a ready position thereof to clamp the peripheral blood test tube; and then moved axially upward along the tube to a suitable height to ensure that the test tube is lifted off the tube rack 5 and lifted to the space between the bottom of the test tube and the top surface of the tube rack 5 allows for horizontal feed insertion of the peripheral blood tube mixing mechanism.
Specifically, the above specific process of performing the mixing operation on the peripheral blood test tube includes steps S31 to S33 shown in fig. 9, and before introducing the corresponding steps of the mixing operation, the peripheral blood test tube mixing mechanism performing the mixing operation is described in detail:
As shown in fig. 10, the peripheral blood test tube mixing mechanism 300: comprises a feeding mechanism, a third horizontal bracket 21, a second horizontal bracket 19, a brushless motor 24 and an eccentric block 26; a test tube bin 22 is arranged on the third horizontal bracket 19, and a test tube support with a concave curved surface is arranged on the second horizontal bracket; the test tube holder 23 is used for supporting a peripheral blood collection tube, and the test tube bin 22 is used for limiting a test tube on the test tube holder 23; the brushless motor 24 of the peripheral blood test tube mixing mechanism drives the eccentric block 26 to rotate around the motor shaft of the brushless motor 24, so as to drive the second horizontal bracket and the test tube holder to swing in a rotary mode.
Further, the feeding mechanism according to the embodiment of the present invention preferably includes: the motor shaft of the horizontal feeding linear motor 13 is fixed on the base 14 of the L-shaped peripheral blood test tube mixing mechanism along the horizontal direction, a horizontal linear guide rail 15 is fixed on the base 14, a fixed block 16 is fixed on a sliding piece corresponding sliding block on the linear guide rail 15, and a movable push plate 17 is respectively connected with the fixed block 16 and a sliding nut of the linear motor 13.
Further, the peripheral blood test tube mixing mechanism 300 further includes a first horizontal bracket 18, the first horizontal bracket 18 is fixed on the fixed block 16, a second horizontal bracket 19 is connected and fixed above the first horizontal bracket 18 by a flexible rubber shock strut 25, and a rubber test tube support 23 with a concave curved surface is fixed on the second horizontal bracket 19; the supporting rod 20 is fixed above the first horizontal bracket 18, and the supporting rod 20 is higher than the second horizontal bracket 19, so that the second horizontal bracket 19 is correspondingly in a crossing area to avoid the clearance; the third horizontal bracket 21 is fixed at the upper end of the supporting rod 20 and is fixedly provided with a through test tube bin 22 thereon, the brushless motor 24 is fixed above the second horizontal bracket 19, the eccentric block 26 is fixed at the output shaft end of the brushless motor 24, the movable push plate 17 is fixedly provided with a horizontal movement position shielding optocoupler baffle 27, and the corresponding horizontal position detection optocoupler 28 is fixed on the base 14.
The working principle of the peripheral blood test tube mixing mechanism 300 according to the embodiment of the invention is as follows: under the drive of the horizontal feeding linear motor 13, the sliding screw of the linear motor 13 drives the moving push plate 17, the optocoupler baffle 27 and the fixed block 16 to perform horizontal movement along the guiding direction of the horizontal linear guide rail 15, and the first horizontal bracket 18, the second horizontal bracket 19, the support rod 20, the third horizontal bracket 21, the through test tube bin 22, the test tube support 23, the brushless motor 24, the flexible rubber shock absorption column 25 and the eccentric block 26 which are arranged on the fixed block 16 in an associated mode synchronously move horizontally. Driven by the brushless motor 24, an eccentric block 26 fixed on the output shaft end of the brushless motor 24 performs rotation around the motor shaft; since the second horizontal bracket 19 for fixing the brushless motor 24 is fixedly connected above the first horizontal bracket 18 through the flexible rubber shock-absorbing column 25 and the rotating shaft hole of the eccentric block 26 is not on the center of gravity thereof, the eccentric block 26 drives the second horizontal bracket 19 to swing and vibrate in a rotating way when rotating.
Specifically, the above specific process of uniformly mixing the peripheral blood test tube is as follows:
Step S31: controlling the test tube clamping jaw to clamp the peripheral blood test tube to ascend;
Step S32: controlling a peripheral blood test tube mixing mechanism to feed to a mixing position, enabling a peripheral blood test tube to be clamped by a test tube clamping jaw to descend, placing the peripheral blood test tube into a through test tube bin of the peripheral blood test tube mixing mechanism, enabling the bottom of the peripheral blood test tube to be in butt joint with a test tube support of the peripheral blood test tube mixing mechanism, and enabling the test tube clamping jaw to perform horizontal feeding to move to a horizontal ready position in a direction away from a test tube rack;
Step S33: the brushless motor of the peripheral blood test tube mixing mechanism drives the eccentric block to rotate, so that the through test tube bin is driven to generate rotary swing, and the blood sample in the peripheral blood test tube abutted by the test tube holder is uniformly mixed.
Optionally, after the performing the blending operation corresponding to the peripheral blood test tube corresponding to the steps S31 to S33, the method further includes the following steps:
Step S34: controlling the test tube clamping jaw to clamp the uniformly mixed peripheral blood test tube to rise so as to lead the peripheral blood test tube to be far away from the through test tube bin;
step S35: the peripheral blood test tube mixing mechanism performs movement in a direction away from the test tube rack;
step S36: and controlling the test tube clamping jaw to clamp and drop the uniformly mixed peripheral blood test tube, and placing the uniformly mixed peripheral blood test tube back into the test tube rack.
Optionally, the step S33 further includes: a brushless motor of the peripheral blood test tube mixing mechanism is driven for a certain time, and the eccentric block rotates around the motor shaft so as to drive the second horizontal bracket to swing in a rotary mode; the bottom of the test tube is rotationally swung along with the second horizontal bracket. The embodiment of the invention falls on a rubber test tube support 23 with a concave curved surface fixed on a second horizontal bracket 19, the bottom of the test tube swings and vibrates rotationally along with the second horizontal bracket 19, and the through test tube bin 22 is relatively static to restrict the tube body of the test tube, so that the bottom of the test tube swings relatively greatly; therefore, the blood sample in the test tube can be uniformly mixed under the combination of centrifugal swing and vibration multiple influences, and meanwhile, the breaking of blood cells is prevented.
Optionally, the mixing operation corresponding to the venous blood test tube includes: the test tube clamping jaw lifts the corresponding test tube from the test tube rack to the upper portion of the test tube rack, and after the test tube clamping jaw is turned upside down and mixed uniformly, the test tube is put back into the test tube rack and the test tube clamping jaw is withdrawn.
Optionally, in the step S35, in the case of identifying the venous blood test tube, the sampling needle descending depth set according to the test tube type corresponding to the venous blood test tube is performed; when the peripheral blood test tube is identified, performing a sampling needle descent depth set in a test tube type of the peripheral blood test tube; the descending depth of the sampling needle arranged in the venous blood test tube is larger than that of the sampling needle arranged in the peripheral blood test tube.
Optionally, the fully automatic sample injection blood cell analysis and measurement device further comprises an automatic counting module for triggering automatic analysis and counting operations on the blood sample, and for the sake of starting, the automatic counting module is provided with an automatic counting key 1 as shown in fig. 2, and the fully automatic sample injection analysis and measurement in the full blood mode can be started by pressing the automatic counting key 1. And, pressing the automatic counting button 1 corresponds to informing the control unit that an analysis is performed once, and the counting operation can be used for counting the number of analysis tubes or checking the number of analysis tubes.
As can be seen from the above description, the method and apparatus for implementing the embodiment of the present invention have the following beneficial effects:
The invention provides a full-automatic sample injection blood cell analysis and measurement method and device, which realize a simpler operation mode of peripheral blood whole blood detection, firstly do not need the external pre-dilution of diluent, secondly do not have strict quantitative requirement influence on a measurement sample, and only need to meet the minimum test dosage requirement, like the measurement mode of venous blood. Meanwhile, the method and the device can automatically identify the types of the venous blood sample collecting test tube and the peripheral blood sample collecting test tube through the detection unit, implement the corresponding blood mixing mode according to the test tube, control the sampling needle to automatically sample and analyze according to different test tube types, and finally output analysis and measurement results. The method and the device provided by the embodiment of the invention have high degree of automation, release the labor intensity of clinical staff and improve the efficiency of blood sample injection and detection.
While the invention has been described in the specification and drawings with reference to a particular embodiment, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention as defined in the claims. Moreover, the combination and organization of features, elements, and/or functions between embodiments herein is clearly apparent, and thus, from this disclosure, one skilled in the art will recognize that features, elements, and/or functions of an embodiment may be optionally incorporated into another embodiment, unless otherwise described. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from the essential scope thereof. Therefore, it is intended that the invention not be limited to the particular embodiment illustrated by the drawings and described in the specification as the best mode presently contemplated for carrying out this invention, but that the invention will include all embodiments falling within the scope of the foregoing description and the appended claims.
Claims (8)
1. A method of determining a tube type, characterized in that the method of determining a tube type determines a tube type of a tube loaded in a tube rack by a tube detection unit, wherein the tube type includes a venous blood tube and a peripheral blood tube, and a bottom thickness of the peripheral blood tube is greater than a bottom thickness of the venous blood tube;
The peripheral blood test tube comprises a tube body, wherein the tube body comprises an outer tube body and an inner tube body, the bottom of the tube body of the inner tube body is positioned in the middle area of the outer tube body, and the lower area of the outer tube body is light-permeable;
The method comprises the following steps:
transmitting a detection signal to a lower region of the cuvette;
Determining whether the test tube is a venous blood test tube or a peripheral blood test tube by detecting photoelectric information of a lower region of the test tube;
when the test tube is a peripheral blood test tube, a peripheral blood test tube mixing mechanism is used for carrying out mixing operation on blood samples in the test tube;
The peripheral blood test tube mixing mechanism comprises a feeding mechanism, at least three horizontal brackets, a flexible column, a through test tube bin, a test tube support with a concave curved surface, a brushless motor and an eccentric block, wherein the brushless motor is positioned on a second horizontal bracket, the test tube support is positioned on a second horizontal bracket, the through test tube bin is positioned on a third horizontal bracket, one end of the flexible column is connected with the first horizontal bracket, and the other end of the flexible column is connected with the second horizontal bracket;
The mixing operation comprises the following steps:
The brushless motor of the peripheral blood test tube mixing mechanism drives the eccentric block to rotate, so that the through test tube bin is driven to swing in a rotary mode, and blood samples in the peripheral blood test tubes which are abutted to the test tube holders are uniformly mixed.
2. The method of claim 1, wherein the cuvette detecting unit is an optical correlation coupler, and the peripheral blood cuvette is transparent or semitransparent to a region of the cuvette body corresponding to the optical correlation coupler.
3. The method of claim 1, wherein the peripheral blood test tube further comprises a cap, and wherein the cap is made of rubber in its entirety or in its middle.
4. The method of claim 1, wherein the bottom of the inner tube is configured as a tapered rounded bottom.
5. The method of claim 1, wherein the outer tube is a skirt extending downward a certain length above the taper of the bottom of the inner tube along the height of the tube.
6. The method of claim 5, wherein the skirt is transparent or translucent near the bottom.
7. The full-automatic sample injection blood cell analysis and measurement device is characterized by comprising a control unit, and further comprising a sample analysis device, a venous blood test tube mixing mechanism, a peripheral blood test tube mixing mechanism, an unloading and withdrawing platform mechanism, a sampling needle, a sample injection loading platform and a test tube detection unit which are connected with the control unit and are controlled by the control unit to execute corresponding operations by sending control instructions;
the sample injection loading platform is used for placing a test tube rack and feeding the test tube rack to the sample analysis mechanism so that the sample analysis mechanism can perform sample analysis measurement on blood samples in test tubes on the test tube rack;
The test tube detection unit is used for detecting the loading condition of test tubes on the test tube rack and the types of the test tubes;
The sampling needle is used for sucking a sample for sample analysis measurement by the sample analysis device;
the venous blood test tube mixing mechanism and/or the peripheral blood test tube mixing mechanism are used for carrying out mixing operation on blood samples in test tubes on the test tube rack;
the unloading and exiting platform mechanism is used for unloading and exiting the test tube rack;
the test tube detection unit is arranged corresponding to the lower area of the test tube;
Determining whether the cuvette is a venous or peripheral blood cuvette by detecting whether a lower region of the cuvette is transparent;
The peripheral blood test tube mixing mechanism comprises a feeding mechanism, at least three horizontal brackets, a flexible column, a through test tube bin, a test tube support with a concave curved surface, a brushless motor and an eccentric block, wherein the brushless motor is positioned on a second horizontal bracket, the test tube support is positioned on a second horizontal bracket, the through test tube bin is positioned on a third horizontal bracket, one end of the flexible column is connected with the first horizontal bracket, and the other end of the flexible column is connected with the second horizontal bracket;
The peripheral blood test tube comprises a tube body, wherein the tube body comprises an outer tube body and an inner tube body, the bottom of the tube body of the inner tube body is positioned in the middle area of the outer tube body, and the lower area of the outer tube body is light-permeable;
The mixing operation comprises the following steps:
The brushless motor of the peripheral blood test tube mixing mechanism drives the eccentric block to rotate, so that the through test tube bin is driven to swing in a rotary mode, and blood samples in the peripheral blood test tubes which are abutted to the test tube holders are uniformly mixed.
8. The apparatus of claim 7, wherein the tube detection unit is an optical coupler, and is configured to be disposed at a mixing position on the sample loading platform or at any working position before the mixing position.
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| CN201910324840.6A CN110398597B (en) | 2018-04-24 | 2019-04-22 | Full-automatic sampling blood cell analysis and measurement method and device and test tube type determination method |
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| CN201910324840.6A Active CN110398597B (en) | 2018-04-24 | 2019-04-22 | Full-automatic sampling blood cell analysis and measurement method and device and test tube type determination method |
| CN201920555266.0U Active CN210401441U (en) | 2018-04-24 | 2019-04-22 | Full-automatic sample injection blood cell analysis and measurement device and peripheral blood test tube |
| CN202011205865.3A Active CN112285369B (en) | 2018-04-24 | 2019-04-22 | Full-automatic sampling blood cell analysis and measurement method and device |
| CN201910324839.3A Active CN110398596B (en) | 2018-04-24 | 2019-04-22 | Full-automatic sample injection blood cell analysis and measurement method and device and method for uniformly mixing peripheral blood test tubes |
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Also Published As
| Publication number | Publication date |
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| CN110398599A (en) | 2019-11-01 |
| CN112326982A (en) | 2021-02-05 |
| CN110398599B (en) | 2021-03-19 |
| CN110398596B (en) | 2023-12-01 |
| CN112285369A (en) | 2021-01-29 |
| WO2019206097A1 (en) | 2019-10-31 |
| CN110398597A (en) | 2019-11-01 |
| CN110398597B (en) | 2021-12-10 |
| CN112285369B (en) | 2021-11-23 |
| CN210401441U (en) | 2020-04-24 |
| CN110398596A (en) | 2019-11-01 |
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