JPS5915835A - Quantitative diluting method and apparatus using light transmitting capillary tube - Google Patents
Quantitative diluting method and apparatus using light transmitting capillary tubeInfo
- Publication number
- JPS5915835A JPS5915835A JP12650382A JP12650382A JPS5915835A JP S5915835 A JPS5915835 A JP S5915835A JP 12650382 A JP12650382 A JP 12650382A JP 12650382 A JP12650382 A JP 12650382A JP S5915835 A JPS5915835 A JP S5915835A
- Authority
- JP
- Japan
- Prior art keywords
- sample
- capillary tube
- dilution
- capillary
- quantitative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Description
【発明の詳細な説明】
この発明は、透光性毛細管を用いて微量の試料を定量し
かつ所定倍率に希釈する方法と、この方法を実施する装
置に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for quantifying and diluting a minute amount of a sample to a predetermined ratio using a transparent capillary tube, and an apparatus for carrying out this method.
病院、検査センターなどでの患者の生化学検査において
は、血液検査をみてもわかるように、近年検体の検査項
目が増加する一方、検体採取は少量化の傾向にあり、か
つ高精度の定量、希釈が要求されている。また、検査の
能率を高めるためには試料の定量、希釈が簡単であるこ
とが必要であるが、微量の試料を簡単にかつ正確に定量
、希釈することは一般に困難である。In biochemical testing of patients at hospitals, testing centers, etc., as can be seen from blood tests, the number of test items for specimens has increased in recent years, while the amount of specimens collected has tended to be smaller. Dilution required. Furthermore, in order to improve the efficiency of testing, it is necessary to be able to easily quantify and dilute a sample, but it is generally difficult to easily and accurately quantify and dilute a minute amount of sample.
この発明の目的は、透光性毛細管を用いて微量の試料を
簡単にかつ正確に定量、希釈できる方法と、この方法を
実施する装置を提供す゛ることにある。An object of the present invention is to provide a method for easily and accurately quantifying and diluting a minute amount of a sample using a translucent capillary tube, and an apparatus for carrying out this method.
この発明の第１のものは、透光性毛細管に毛細管現象を
利用して試料を採取し、この試料の液面が所定高さにな
るまで吸水性材料で試料を吸取ることによって定量を行
ない、所定量の希釈液をこの毛細管の一端から注入して
試料とともに毛細管の他端から出すことにより試料を所
定倍率に希釈することを特徴とする透光性毛細管を用い
た定置希釈方法であり、この発明の第２のものは、上記
方法の発明の実施に直接使用する装置であって、この装
置は、試料が採取さ３−
れた透光性毛細管を所定位置に縦に固定して試料の定量
を行なう定量部と、定量後の毛細管を上記と同じ位置ま
たは別の所定位置に固定して試料の希釈を行なう希釈部
とからなり、定量部が、光電式液面検出器、移動自在な
吸水性材料、おにび毛細管内の試料の液面が所定高さに
なったことを液面検出器で検知するまで吸水性材料を毛
細管の下端に接触させて試料を吸取らせる吸水性材料駆
動機構を備え、希釈部が、予め希釈液が入れられて毛細
管の一端に接続されるシリンジ、およびシリンジで所定
量の希釈液を毛細管の一端から注入して試料とともに毛
細管の他端から出すシリンジ駆動機構を備えていること
を特徴とするものである。The first aspect of the invention is to collect a sample using a translucent capillary tube using capillary phenomenon, and perform quantitative determination by absorbing the sample with a water-absorbing material until the liquid level of the sample reaches a predetermined height. , a stationary dilution method using a translucent capillary, characterized in that the sample is diluted to a predetermined magnification by injecting a predetermined amount of diluent from one end of the capillary and expelling it together with the sample from the other end of the capillary; The second aspect of the present invention is an apparatus directly used for carrying out the invention of the method described above. The quantitative part consists of a quantitative part that performs quantitative determination, and a diluent part that dilutes the sample by fixing the capillary tube after quantitative determination at the same position or another predetermined position. A water-absorbing material that absorbs the sample by bringing the water-absorbing material into contact with the lower end of the capillary until the liquid level detector detects that the liquid level of the sample in the capillary has reached a predetermined height. The diluting unit includes a syringe that is prefilled with a diluent and is connected to one end of the capillary, and a syringe that injects a predetermined amount of the diluent from one end of the capillary and discharges it together with the sample from the other end of the capillary. It is characterized by being equipped with a syringe drive mechanism.
この発明によれば、透光性毛細管内の試料の液面が所定
高さになるまで吸水性材料で試料を５−
４−
吸取る簡単な操作により、試料の定量を正確に行なうこ
とができ、所定量の希釈液を毛細管の一端から注入する
簡単な操作により、試料を毛細管から迅速に取出すとと
もにこれを正確に希釈することができる。According to this invention, the sample can be quantified accurately by a simple operation of absorbing the sample with a water-absorbing material until the liquid level of the sample in the translucent capillary reaches a predetermined height. By simply injecting a predetermined amount of diluent into one end of the capillary tube, the sample can be quickly removed from the capillary tube and diluted accurately.
以下図面を参照してこの発明の詳細な説明する。The present invention will be described in detail below with reference to the drawings.
図面は透明ガラス製の透光性毛細管（１）と定石希釈装
置を用いて血液などの試料の定量、希釈を行なう場合を
示している。The drawing shows a case where a sample such as blood is quantified and diluted using a translucent capillary tube (1) made of transparent glass and a regular dilution device.
毛細管（１）の内径は精度良（管理され、複数の毛細管
（１）相互の内径のばらつきもほとんどない。このため
、毛細管（１）内の試料の長さを一定にすれば一定量の
試料が採取されることになる。The inner diameter of the capillary tube (1) is controlled with good precision, and there is almost no variation in the inner diameter of multiple capillary tubes (1).For this reason, if the length of the sample in the capillary tube (1) is constant, a certain amount of sample can be will be taken.
定量希釈装置は、試料が採取された毛細管６−
（１）を所定位置に縦に固定して試料の定量を行なう定
量部と、定置後の毛細管（１）を上記と同じ位置または
別の位置に縦に固定して試料の希釈を行なう希釈部とか
らなる。The quantitative dilution device consists of a quantitative part that quantifies the sample by vertically fixing the capillary tube 6-(1) from which the sample has been collected in a predetermined position, and a quantitative part that quantifies the sample by vertically fixing the capillary tube 6-(1) from which the sample was collected, and a quantitative diluting section that quantifies the sample by vertically fixing the capillary tube 6-(1) from which the sample has been collected, and the capillary tube 6-(1) after being fixed in place at the same position or a different position. and a dilution section that is fixed vertically to dilute the sample.
定量部の構成は第２図に示されており、定量部には、光
電式液面検出器（２）と移動自在な吸取紙（吸水性材料
）（３）が設けられている。The configuration of the quantification section is shown in FIG. 2, and the quantification section is provided with a photoelectric liquid level detector (2) and a movable absorbent paper (water-absorbing material) (3).
液面検出器（２）は、毛細管（１）を挾んで対向状に配
置された発光ダイオード（４）とホトトランジスタ（５
）により毛細管（１）内の試料の透過光量を測定して試
料の液面を検出するものであり、発光ダイオード（４）
およびホトトランジスタ（５）は液面検知回路（６）に
接続されている。また、発光ダイオード（４）およびホ
トトランジスタ（５）と毛細管（１）との間には、測定
精度をあげるために、スリン１−（７）がそれぞれ設け
られている。このスリンｉ〜（７）は、毛細管（１）の
下端から所定高さの位置に配置されている。吸取紙（３
）は、モータまたはソレノイドなどを用いた吸取紙駆動
機構（８）によって駆動され、毛細管（１）の下端に接
触したりこれから離れたりする。そして、液面検知回路
（６）と吸取紙駆動機構（８）との間には、吸取紙駆動
回路（９）が設けられでいる。The liquid level detector (2) consists of a light emitting diode (4) and a phototransistor (5) which are arranged opposite to each other with the capillary tube (1) in between.
) to detect the liquid level of the sample by measuring the amount of light transmitted through the sample in the capillary (1), and the light emitting diode (4)
And the phototransistor (5) is connected to a liquid level detection circuit (6). Additionally, Surins 1-(7) are provided between the light emitting diode (4) and the phototransistor (5) and the capillary tube (1), respectively, in order to improve measurement accuracy. The sulins i to (7) are arranged at a predetermined height from the lower end of the capillary tube (1). Blotting paper (3
) is driven by a blotting paper drive mechanism (8) using a motor or solenoid or the like to contact and move away from the lower end of the capillary tube (1). A blotting paper drive circuit (9) is provided between the liquid level detection circuit (6) and the blotting paper drive mechanism (8).
希釈部の構成は第３図に示されており、希釈部には、継
手（１０）を介して毛細管（１）の上端に接続されるシ
リンジ（１１）と、パルスモータなどを用いたシリンジ
駆動１１１構（１２）が設けられている。シリンジ（１
１）には予め希釈液が入れられ、毛細管（１）の下方に
はサンプルカップ（１３）が配置される。The configuration of the dilution section is shown in Figure 3, and the dilution section includes a syringe (11) connected to the upper end of the capillary tube (1) via a joint (10), and a syringe drive unit using a pulse motor or the like. There are 111 structures (12). Syringe (1
1) is filled with a diluent in advance, and a sample cup (13) is placed below the capillary tube (1).
＝７−
試料の採取、定量および希釈は、次のようにして行なわ
れる。=7- Sample collection, quantitative determination, and dilution are performed as follows.
まず、第１図に示されているように、毛細管（１）に毛
細管現象を利用して試料を採取する。First, as shown in FIG. 1, a sample is collected in a capillary tube (1) using capillary action.
このときの試料の採取量は、必要量より条目にする。The amount of sample to be collected at this time is determined by the required amount.
次に、この毛細管（１）を定量部の所定位置に縦に固定
する。毛細管（１）が固定されると、液面検出器（２）
が作動するとともに、吸取紙駆動機構（８）が作動して
吸取紙（３）が毛細管（１）の下端に接触し、吸取紙（
３）で試料が吸取られてその液面が徐々に低下する。そ
して、スリット（７）の位置まで液面が下がって液面検
知回路（６）がこれを検知すると、吸取紙駆動回路（９
）に信号が送られ、さらにこの信号により吸取紙駆動機
構（８）が作動して、９−
８−
吸取紙（３）が毛細管（１）の下端から離れる。Next, this capillary tube (1) is vertically fixed at a predetermined position in the metering section. Once the capillary tube (1) is fixed, the liquid level detector (2)
is activated, the blotting paper drive mechanism (8) is activated and the blotting paper (3) comes into contact with the lower end of the capillary tube (1), and the blotting paper (
In step 3), the sample is sucked up and the liquid level gradually decreases. When the liquid level falls to the position of the slit (7) and the liquid level detection circuit (6) detects this, the blotting paper drive circuit (9) detects this.
), which in turn activates the blotting paper drive mechanism (8) to move the blotting paper (3) away from the lower end of the capillary tube (1).
これにより、毛細管（１）内に、所定高さすなわち所定
量の試料が正確に採取される。Thereby, a sample of a predetermined height, that is, a predetermined amount, is accurately collected into the capillary tube (1).
次に、この毛細管（１）を希釈部の所定位置に縦に固定
し、シリンジ（１１）に接続された継手（１０）を毛細
管（１）の上端に接続する。毛細管（１）に継手（１０
）が接続されると、シリンジ駆動機構（１２）が作動し
、シリンジ（１１）より所定量の希釈液を送り出して毛
細管（１）の上端から注入する。毛細管（１）の上端か
ら注入された希釈液は試料とともに毛細管（１）の下端
からサンプルカップ（１３）に送り出され、これにより
、所定倍率に正確に希釈された試料がサンプルカップ（
１３）内に得られる。また、シリンジ駆動機構（１２）
にたとえばパルスモータを用いれば、精度の高い希釈が
可能である。Next, this capillary tube (1) is fixed vertically at a predetermined position in the dilution section, and a joint (10) connected to a syringe (11) is connected to the upper end of the capillary tube (1). Fitting (10) to capillary (1)
) is connected, the syringe drive mechanism (12) is activated, and a predetermined amount of diluent is sent out from the syringe (11) and injected from the upper end of the capillary tube (1). The diluent injected from the upper end of the capillary tube (1) is sent together with the sample from the lower end of the capillary tube (1) to the sample cup (13), whereby the sample accurately diluted to a predetermined ratio is delivered to the sample cup (13).
13) Obtained within. In addition, the syringe drive mechanism (12)
For example, if a pulse motor is used, highly accurate dilution is possible.
−１ｌ′Ｘ −
なお、シリンジ（１１）から送り出される希釈液の聞は
、毛細管（１）から試料を送り出したときに毛細管（１
）内に残る希釈液の量などを考慮して決められる。-1l'X
) is determined by considering the amount of diluent remaining in the tank.
内径の異なる毛細管を用いるか、あるいは液面検出器（
２）およびスリット（７）の位置（高さ）を可変にする
ことによって試料の採取量を調整することができ、シリ
ンジ（１１）の移動量を可変にすることによって試料の
希釈倍率を調整することができる。Use capillary tubes with different inner diameters or use a liquid level detector (
2) The amount of sample collected can be adjusted by making the position (height) of the slit (7) variable, and the dilution factor of the sample can be adjusted by making the amount of movement of the syringe (11) variable. be able to.
定量部および希釈部において毛細管を固定する手段は任
意であり、毛細管を１箇所に固定した状態で定量と希釈
を行なうようにしてもよいし、試料を定量採取後の毛細
管を定量部から希釈部に移して希釈を行なうようにして
もよい。The means for fixing the capillary tubes in the quantitative section and the diluting section is arbitrary; the capillary tube may be fixed in one place for quantitative determination and dilution, or the capillary tube after quantitative sample collection can be moved from the quantitative section to the diluting section Alternatively, dilution may be carried out by transferring to
毛細管を定量部から希釈部に移す手段は任意であり、手
操作によってもよいし、たとえば毛細管を固定するター
ンテーブルの回転移動径路上に定量部と希釈部を配置し
ておき、ターンテーブルの回転によって定量部から希釈
部に毛細管を自動的に移動させるようにしてもよい。ま
た、１箇所に固定された毛細管に対して定量および希釈
を自動的に行なう機構またはターンテーブルなどによっ
て自動的に移動Ｊ−る毛細管に対して定石および希釈を
自動的に行なう機構と、サンプルカップの自動送り機構
などを連結した自動化システムを構成すれば、迅速にか
つ非常に正確に試料を定量、希釈できる装置が実現され
る。The means for transferring the capillary tube from the metering section to the dilution section is arbitrary, and may be done manually, or, for example, by placing the metering section and dilution section on the rotational movement path of a turntable that fixes the capillary tube, and then moving the capillary tube from the metering section to the dilution section. The capillary tube may be automatically moved from the quantification section to the dilution section. In addition, there is a mechanism that automatically performs quantitative determination and dilution for a capillary fixed in one place, or a mechanism that automatically performs fixed determination and dilution for a capillary that is automatically moved by a turntable, etc., and a sample cup. By configuring an automated system that connects an automatic feeding mechanism, etc., an apparatus that can quickly and accurately quantify and dilute a sample can be realized.
図面はこの発明の実施例を示し、第１図は透明ガラス製
の透光性毛細管に試料を採取してい１１−
る状態を示す側面図、第２図は定量希釈装置の定量部の
構成を示すブロック図、第３図は定量希釈装置の希釈部
の構成を示すブロック図である。
（１）・・・透光性毛細管、（２）・・・光電式液面検
出器、（３）・・・吸取紙（吸水性材料）、（８）・・
・吸取紙（吸水性材料）駆動機構、（１１）・・・シリ
ンジ、（１２）・・・シリンジ駆動機構。
以−ト
＝ １３−
＝１２−The drawings show an embodiment of the present invention, and Fig. 1 is a side view showing a sample being collected into a translucent capillary tube made of transparent glass, and Fig. 2 shows the configuration of the quantitative portion of the quantitative dilution device. FIG. 3 is a block diagram showing the configuration of the dilution section of the quantitative dilution device. (1)...Translucent capillary tube, (2)...Photoelectric liquid level detector, (3)...Blotter paper (water-absorbing material), (8)...
- Absorbent paper (water absorbent material) drive mechanism, (11)...Syringe, (12)...Syringe drive mechanism. Below = 13- =12-
Claims (4)
料を採取し、この試料の液面が所定高さになるまで吸水
性月利（３）で試料を吸取ることによって定量を行ない
、所定量の希釈液をこの毛細管（１）の一端から注入し
て試料とともに毛細管（１）の他端から出すことにより
試料を所定倍率に希釈することを特徴とする透光性毛細
管を用いた定量希釈方法。(1) Collect a sample using the capillary edge of the translucent capillary tube (1), and quantify the sample by absorbing it with the water-absorbent tube (3) until the liquid level of the sample reaches a predetermined height. The sample is diluted to a predetermined ratio by injecting a predetermined amount of diluent from one end of the capillary tube (1) and expelling it together with the sample from the other end of the capillary tube (1). quantitative dilution method.
になったことを光電式液面検出器（２）で検知すること
を特徴とする特許請求の範囲第１− １項に記載の定量希釈方法。(2) Claim 1-1 characterized in that a photoelectric liquid level detector (2) detects when the liquid level of the sample in the translucent capillary (1) reaches a predetermined height. Quantitative dilution method described in section.
の希釈液を透光性毛細管（１）の一端から注入すること
を特徴とする特許請求の範囲第１項または第２項に記載
の定量希釈方法。(3) A predetermined amount of the diluent is injected from one end of the translucent capillary tube (1) using a syringe (11) containing the diluent in advance, according to claim 1 or 2. Quantitative dilution method.
置に縦に固定して試料の定量を行イ１う定量部と、定量
後の毛細管（１）を上記と同じ位置また（よ別の所定位
置に固定して試料の希釈を行なう希釈部とからなり、定
量部が、光電式液面検出器（２）、移動自在な吸水性Ｉ
利（３）、および毛細管（１）内の試料の液面が所定高
さになったことを液面検出器（２）で検知するまで吸水
性材料（３）を毛細管（１）の下端に接触させて試料を
吸取らせる吸水性材料駆動ｔａ構（８）を備え、希釈部
が、予め希釈液が入れられて毛細管（１）の一端に接続
されるシリンジ（１１）、およびシリンジ（１１）で所
定量の希釈液を毛細管（１）の一端から注入して試料と
ともに毛細管（１）の他端から出すシリンジ駆動機構（
１２）を備えていることを特徴とする透光性毛細管を用
いた定量希釈装置。(4) The translucent capillary tube (1) from which the sample was collected is vertically fixed in a predetermined position and the sample is quantified. The quantitative part consists of a photoelectric liquid level detector (2), a movable water absorbent I
(3) and the water-absorbing material (3) at the lower end of the capillary tube (1) until the liquid level detector (2) detects that the liquid level of the sample in the capillary tube (1) has reached a predetermined height. A syringe (11) is provided with a water-absorbing material driving mechanism (8) that allows the sample to be brought into contact with it to absorb the sample, and a diluting section is connected to one end of the capillary tube (1) in which a diluent is previously filled, and the syringe (11) ), a syringe drive mechanism (
12) A quantitative dilution device using a translucent capillary tube.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12650382A JPS5915835A (en) | 1982-07-19 | 1982-07-19 | Quantitative diluting method and apparatus using light transmitting capillary tube |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12650382A JPS5915835A (en) | 1982-07-19 | 1982-07-19 | Quantitative diluting method and apparatus using light transmitting capillary tube |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5915835A true JPS5915835A (en) | 1984-01-26 |
Family
ID=14936815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12650382A Pending JPS5915835A (en) | 1982-07-19 | 1982-07-19 | Quantitative diluting method and apparatus using light transmitting capillary tube |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5915835A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62297756A (en) * | 1986-06-17 | 1987-12-24 | Shimadzu Corp | Automatic biochemical analyzer |
| JP2003507715A (en) * | 1999-08-13 | 2003-02-25 | カーティージャン テクノロジーズ、 インコーポレイテッド | Liquid sample handling equipment |
| EP1541986A1 (en) * | 2003-12-12 | 2005-06-15 | Boehringer Ingelheim microParts GmbH | Sampling device for examining a fluid sample |
| CN101871859A (en) * | 2010-06-23 | 2010-10-27 | 苏州聚阳环保科技有限公司 | Method and equipment for diluting high-concentration solution to be tested in dynamic flow way |
| CN113423504A (en) * | 2019-02-12 | 2021-09-21 | 玛格纳森斯科技有限公司 | Sample processing device |
-
1982
- 1982-07-19 JP JP12650382A patent/JPS5915835A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62297756A (en) * | 1986-06-17 | 1987-12-24 | Shimadzu Corp | Automatic biochemical analyzer |
| JPH0565826B2 (en) * | 1986-06-17 | 1993-09-20 | Shimadzu Corp | |
| JP2003507715A (en) * | 1999-08-13 | 2003-02-25 | カーティージャン テクノロジーズ、 インコーポレイテッド | Liquid sample handling equipment |
| EP1541986A1 (en) * | 2003-12-12 | 2005-06-15 | Boehringer Ingelheim microParts GmbH | Sampling device for examining a fluid sample |
| US7318359B2 (en) | 2003-12-12 | 2008-01-15 | Boehringer Ingelheim Microparts Gmbh | Sampling means and system for testing a sample liquid |
| CN101871859A (en) * | 2010-06-23 | 2010-10-27 | 苏州聚阳环保科技有限公司 | Method and equipment for diluting high-concentration solution to be tested in dynamic flow way |
| CN113423504A (en) * | 2019-02-12 | 2021-09-21 | 玛格纳森斯科技有限公司 | Sample processing device |
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