CN107152953A - A kind of detecting liquid level method and device being loaded suitable for glycosylated hemoglobin - Google Patents
A kind of detecting liquid level method and device being loaded suitable for glycosylated hemoglobin Download PDFInfo
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- CN107152953A CN107152953A CN201710216701.2A CN201710216701A CN107152953A CN 107152953 A CN107152953 A CN 107152953A CN 201710216701 A CN201710216701 A CN 201710216701A CN 107152953 A CN107152953 A CN 107152953A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
- G01F23/22—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water
- G01F23/26—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring variations of capacity or inductance of capacitors or inductors arising from the presence of liquid or fluent solid material in the electric or electromagnetic fields
- G01F23/263—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring variations of capacity or inductance of capacitors or inductors arising from the presence of liquid or fluent solid material in the electric or electromagnetic fields by measuring variations in capacitance of capacitors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1011—Control of the position or alignment of the transfer device
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N2035/1025—Fluid level sensing
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Abstract
The invention discloses a kind of detecting liquid level method and device being loaded suitable for glycosylated hemoglobin in detecting liquid level field；Methods described includes：While liquid absorbing probe part does test campaign, synchronous acquisition optical signal, capacitance signal, the state of resistance signal are kept；The optical signal, capacitance signal, resistance signal are received, and instructs liquid absorbing probe part to stop test campaign according to the situation of change of the signal, complete imbibition；The situation of change of the signal is specifically included：Optical signal strong and weak threshold values strong and weak with default photosignal match, capacitance signal changing value is more than default electric capacity and detects threshold values, there is impedance path；Wherein, instruction liquid absorbing probe part can be completed by foundation of one kind in the situation of change got at first to stop liquid level test campaign, complete imbibition；Described device includes liquid absorbing probe part, sample arm, motion control mechanism, control circuit module.The present invention solves the low defect of single detecting liquid level mode reliability.
Description
Technical field
The present invention relates to detecting liquid level field used in medical inspection alanysis instrument, and in particular to one kind is applied to saccharification
The detecting liquid level method and device of hemoglobin sample-adding.
Background technology
Detecting liquid level application at present applied to medical inspection kind equipment is quite extensive, in the hospitals of various ranks, disease control
The heart, blood station and laboratory all must be equipped with various detection devices, such as automatic clinical chemistry analyzer, automatic coagulation analyzer, complete
Automatic specific protein analyzer, full-automatic blood cell analysis machine etc..These equipment will by sample needle pipette samples (whole blood, serum,
Urine etc.) and reagent reacted to reaction tank.Due to being to have same suction needle, sample and reagent can thus be produced
Cross pollution, in order to reduce cross pollution, allows suction needle to touch liquid level and is automatically stopped test, starts to draw sample or reagent.
This requires liquid level to touch the moment of suction needle, and accurate judgement, maximum limit are made by corresponding highly sensitive detecting system
Degree reduces the liquid carrying amount of liquid-transfering needle outer surface, it is to avoid cross pollution.
Detecting liquid level technology on the market is all by electric-resistivity method, pressure application, condenser type etc. at present, and different methods has certainly
The defect of body：Electric-resistivity method is that more early instrument uses conventional contact detection method, and the method is touched using two metal pole pieces
An impedance path is formed after liquid level so as to judge whether to touch sample, the advantage of the method is fairly simple, easily realizes, but
False Rate is very high, hangs when drop, temperature are less than 0 DEG C and can not use when encountering the higher sample of impedance, sample, has no idea to be applied to
Different types of Samples detection；Pressure application can see the method on a small amount of detecting instrument, and its principle is micro by one
Air pump string a fixed pressure is formed in sample pin loop as reference pressure source, pressure moment after liquid level is touched
Become big, corresponding amplification treatment circuit is sent to by pressure sensor, so as to control to be loaded needle movement, it has the disadvantage to realize
Come more complicated, and sealed by pipeline, pin hole inner arm foreign materials away than larger, fault rate is higher etc.；Capacitance method is most general at present
And a kind of method, instrument is using the accounting of its method more than 90% on the market at present, and its detection principle is, suction needle with
There is a fixed reference field electric capacity between sample (or reagent), a mutation electricity is produced when the moment that suction needle is contacted with sample
Hold, by a series of circuit conversion and signal transacting, the formation of final triggering detecting liquid level signal, by controlling motion
Stop sample needle test, the method is realized relatively easy, and fault rate is relatively low with respect to other two methods, but the examined sample of capacitance method
Product environment distribution capacity, sample selfcapacity, electromagnetic interference, the even influence such as environment temperature can all cause erroneous judgement, so as to cause
Instruction of the detecting liquid level system to main control circuit mistake in communication, causes to inhale sample mistake, causes the cross pollution of sample, reagent,
Sample test mistake may be caused when serious, serious consequence may be brought to patient by misleading doctor's medication.
The content of the invention
For the drawbacks described above of prior art, it is an object of the invention to provide a kind of suitable with multiple detecting liquid level pattern
The detecting liquid level method and device being loaded for glycosylated hemoglobin, solves the low defect of single detecting liquid level mode reliability.
The purpose of the present invention is achieved by the following technical solution：
In a first aspect, the present invention provides a kind of liquid detection device being loaded suitable for glycosylated hemoglobin, including：Imbibition
Probe member, sample arm, motion control mechanism, control circuit module；Wherein,
The liquid absorbing probe part, for gathering and output capacitance, resistance, optical signal, pipette samples；
The sample arm, is connected with the liquid absorbing probe part, is inhaled for driving the liquid absorbing probe part to complete sample
Take；
The motion control mechanism, is connected with the sample arm, for control the sample arm in the horizontal direction, Vertical Square
Upward motion；
The control circuit module, electric capacity, resistance, optical signal for receiving the liquid absorbing probe part output, and according to
This control motion control mechanism makes it drive sample arm to move in the horizontal direction, in vertical direction.
As a kind of concrete form in embodiment, the liquid absorbing probe part, including imbibition needle tubing and located at it is described inhale
Electric capacity probe portion, impedance part on liquid needle tubing, photodetection portion, the electric capacity probe portion, impedance part, photodetection portion are along imbibition
Needle tubing y direction is successively away from the imbibition needle tubing liquid sucting port end.
As a kind of concrete form in embodiment, the electric capacity probe portion is the capacitive suction sample mouth of imbibition needle tubing.
As a kind of concrete form in embodiment, the impedance part is arranged at the electric capacity probe portion and visited with the photoelectricity
Between survey portion, to surround the metal body of the imbibition needle tubing.
As a kind of concrete form in embodiment, the photodetection portion includes bar shape photoelectricity radome and is arranged at
The photoelectric sensor of the photoelectricity radome bottom, imbibition needle tubing runs through the photoelectricity radome and liquid sucting port end along y direction
Part is exposed.
As a kind of concrete form in embodiment, the motion control mechanism includes horizontal movement control piece and vertical fortune
Dynamic control piece.
As a kind of concrete form in embodiment, the control circuit module includes current-to-voltage converting circuit, computing
Amplifier, voltage comparator, microprocessor, capacitance-resistance receive concussion finishing circuit.
Second aspect, the present invention provides a kind of detecting liquid level method being loaded suitable for glycosylated hemoglobin, applied to complete
The liquid detection device of automatic specific protein analyzer, comprises the following steps：
S101, while liquid absorbing probe part does test campaign, keeps synchronous acquisition optical signal, capacitance signal, resistance
The state of signal；
S102, receives the optical signal, capacitance signal, resistance signal, and instruct suction according to the situation of change of the signal
Liquid probe member stops test campaign, completes imbibition；The situation of change of the signal is specifically included：Optical signal it is strong and weak with it is default
The matching of photosignal power threshold values, capacitance signal changing value are more than default electric capacity detection threshold values, there is impedance path；
Wherein, it can complete to instruct liquid absorbing probe part using one kind in the situation of change got at first as foundation
Stop liquid level test campaign, complete imbibition.
As a kind of concrete form in embodiment, in S102, the setting of the strong and weak threshold values of the optical signal is specially：Imbibition
There is corresponding relation in probe member, such as need liquid absorbing probe part to rest on apart from liquid level apart from the height and light signal strength of liquid level
Stop test during default height, complete imbibition, then the default highly corresponding light signal strength is that optical signal is strong and weak
Threshold values.
As a kind of concrete form in embodiment, in S102, the setting of the electric capacity detection threshold values is specially：Not consubstantiality
Product treats that the capacitance of imbibition is different, and the suction sample mouth of liquid absorbing probe part contacts the overlap capacitance value difference of rear moment generation,
Correspondingly, the corresponding concussion frequency of overlap capacitance value is different；As needed liquid absorbing probe part to be inhaled at it sample mouth touches and treat imbibition
Moment stops test, completes imbibition, then the corresponding concussion frequency of the overlap capacitance value and the blank benchmark frequency detected
The changing value of rate is electric capacity detection threshold values.
Compared with prior art, the embodiment of the present invention possesses following beneficial effect：
The detecting liquid level method of the present invention uses non-singularity detecting liquid level pattern, can ensure that full-automatic specific protein is analyzed
Instrument avoids the cross pollution caused, sample leakage from inhaling, miss the phenomenons such as suction in pipette samples, it is ensured that the accuracy of sample-adding, is instrument
Sample-adding detection provide ensure.
Brief description of the drawings
Fig. 1 is liquid detection device structural representation provided in an embodiment of the present invention；
Fig. 2 is the full-automatic specific protein analyzer overall structure using liquid detection device provided in an embodiment of the present invention
Schematic diagram；
Fig. 3 is the liquid absorbing probe part close-up schematic view of liquid detection device provided in an embodiment of the present invention；
Wherein, 10- liquid absorbing probes part, 11- imbibition needle tubings, 12- electric capacity probe portions, 13- impedance parts, 14- photoelectricity
Probe portion, 141- photoelectric sensors, 1411- photoemission end, 1412- opto-electronic receivers end, 142- photoelectricity radomes, 20-
Sample arm, 30- motion control mechanisms, 31- horizontal movement control pieces, 32- vertical movement control pieces, 40- control circuit moulds
Block, 50- sample reagent discs, 60- sample reagents bottle.
Specific embodiment
For the ease of understanding the present invention, below in conjunction with the accompanying drawings and specific embodiment, the present invention will be described in more detail.
It should be noted that when element is expressed " being fixed on " another element, it can directly on another element or therebetween
There may be one or more elements placed in the middle.When an element is expressed " connection " another element, it can directly be connected
It is connected to another element or there may be one or more elements placed in the middle therebetween.Term used in this specification is " vertical
", " level ", "left", "right" and similar statement for illustrative purposes only.
Unless otherwise defined, technology all used in this specification and scientific terminology are led with belonging to the technology of the present invention
The implication that the technical staff in domain is generally understood that is identical.Used term is to be in the description of the invention in this specification
The purpose of description specific embodiment, is not intended to the limitation present invention.Term "and/or" used in this specification includes one
The arbitrary and all combination of individual or multiple related Listed Items.
Refering to Fig. 1, Fig. 3, the embodiment of the present invention provides a kind of liquid detection device being loaded suitable for glycosylated hemoglobin
100, including：Liquid absorbing probe part 10, sample arm 20, motion control mechanism 30, control circuit module 40；Wherein,
The liquid absorbing probe part 10, for gathering and output capacitance signal, resistance signal, optical signal, pipette samples；
The sample arm 20, is connected with the liquid absorbing probe part 10, for driving the liquid absorbing probe part 10 to complete
Sample is drawn；
The motion control mechanism 30, is connected with the sample arm 20, for control the sample arm 20 in the horizontal direction,
The motion of vertical direction；
The control circuit module 40, for receive capacitance signal, resistance signal that the liquid absorbing probe part 10 exports,
Optical signal, and control motion control mechanism 30 is moved in the horizontal direction, in vertical direction accordingly.
Above-mentioned liquid absorbing probe part 10, including imbibition needle tubing 11 and the electric capacity probe portion on the imbibition needle tubing 11
12nd, impedance part 13, photodetection portion 14, the electric capacity probe portion 12, impedance part 13, photodetection portion 14 are vertical along imbibition needle tubing 11
Direction of principal axis is successively away from the liquid sucting port end of imbibition needle tubing 11.
In certain embodiments, the electric capacity probe portion 12 refers specifically to the capacitive suction sample mouth of imbibition needle tubing 11.
In certain embodiments, the material for inhaling sample mouth uses insulating materials, such as rubber, plastics, glass, ceramics.
In certain embodiments, the impedance part 13 be arranged at the electric capacity probe portion 12 and the photodetection portion 14 it
Between, to surround the metal body of the imbibition needle tubing 11.
In certain embodiments, the photodetection portion 14 includes bar shape photoelectricity radome 142 and is arranged at the light
The photoelectric sensor 141 of the bottom of electrical shielding cover 142, imbibition needle tubing 11 is along y direction is through the photoelectricity radome 142 and inhales
Exceptionally reveal liquid mouthful end.
In certain embodiments, the photoelectricity radome 142 uses insulating materials, such as rubber, plastics, glass, ceramics.
In certain embodiments, distance of the photoelectric sensor 141 apart from the liquid sucting port end of liquid absorbing probe part 10
For 10-20mm.
In certain embodiments, the photoelectric sensor 141 includes photoemission end 1411 and opto-electronic receiver end 1412.
In certain embodiments, above-mentioned motion control mechanism 30 includes horizontal movement control piece 31 and vertical movement control piece
32。
Above-mentioned control circuit module 40, including current-to-voltage converting circuit, operational amplifier, voltage comparator, microprocessor
Device etc..
The full-automatic specific of the liquid detection device 100 that the embodiment of the present invention is loaded suitable for glycosylated hemoglobin is installed
Protein analyzer is shown in Fig. 2.For the ease of skilled artisan understands that technical scheme, work of the inventor to the present invention
Industry pattern is illustrated as follows：
Control circuit module 40 includes current-to-voltage converting circuit, operational amplifier, voltage comparator and microprocessor etc.,
Capacitance signal, resistance signal, optical signal for being exported according to liquid absorbing probe part 10 instruct and control motion control machine accordingly
From sample reagent 60 pipette samples of bottle at structure 30, driving liquid absorbing probe part 10 to sample reagent disc 50.When vertical movement control
The photoemission end 1411 of photoelectric sensor 141 is by launching infrared light not when the drive liquid absorbing probe of part 32 part 10 is down run
The suction sample mouth distance of the detection imbibition needle tubing 11 of interruption treats the distance of imbibition liquid level, treats that imbibition liquid level distance inhales sample mouth by detection
Distance, opto-electronic receiver end 1412 can receive different light signal intensity, and the Current Voltage for passing through light to electricity is changed, computing
The signal amplification of amplifier, the comparison of voltage comparator, the comprehensive analysis of microprocessor, to judge the height for treating imbibition liquid level,
Motion control mechanism 30 is controlled by control circuit module 40 again, imbibition spy should be stopped after liquid level immediately when inhaling sample mouth and touching
The test detection operation of needle part 10, completes detecting liquid level.
The action principle of photoelectric sensor 141 is：Photoelectric sensor 141 is switching device of the light to electric signal, and work rank
The continual transmitting infrared light in section photoemission end 1411, is reflected back when photoelectric sensor 141 is close to liquid level different distance
The intensity of the light at opto-electronic receiver end 1412 is different, and the enhanced processing of the photosignal through oversampling circuit is input to A/D conversion and control IC,
By by different distance, the photosignal threshold value setting of different liquids to program, being matched somebody with somebody by the strong and weak threshold values formation of electric signal
To relation.This is that those skilled in the art can generally realize.
Liquid absorbing probe part 10 touches the moment of liquid level, and liquid absorbing probe part 10 is with treating that imbibition liquid level formation one is superimposed
Electric capacity, produces a capacitance signal.The capacitance-resistance that this capacitance signal moment is sent to control circuit module 40 receives concussion arrangement electricity
Road, touching concussion frequency after liquid level can have greatly changed, by shaking the contrast of frequency with vacant base value, according to concussion
The variable quantity of frequency come determine whether contact liquid level, by the different amounts of capacitance for treating that imbibition is formed also has larger difference
Different, this requires to set different threshold values, and such as full-automatic specific protein detecting liquid level allows minimum amount of liquid to be 100uL, works as suction
Liquid probe member 10 when touching relevant position 100uL sample it is produced concussion frequency compared with its vacant reference frequency,
Its changing value is calculated, is its minimum suction amount detection threshold values.
When photodetection portion 14, electric capacity probe portion 12 lose work capacity, liquid absorbing probe part 10 is in sample arm 20
Lower continuation test is driven, an impedance path is formed with impedance part 13 behind liquid level contact impedance portion 13, so as to excite capacitance-resistance
Circuit is detected, resistance signal is produced, the resistance signal is exaggerated, compared, is input to micro-chip processor and judged, by control electricity
Road module 40 controls motion control mechanism 30 out of service according to resistance signal.
The embodiment of the present invention also provides a kind of detecting liquid level method being loaded suitable for glycosylated hemoglobin, applied to it is complete from
The liquid detection device of dynamic specific protein analyzer, comprises the following steps：
S101, while liquid absorbing probe part does test campaign, keeps synchronous acquisition optical signal, capacitance signal, resistance
The state of signal；
S102, receives the optical signal, capacitance signal, resistance signal, and instruct suction according to the situation of change of the signal
Liquid probe member stops test campaign, completes imbibition；The situation of change of the signal is specifically included：Optical signal it is strong and weak with it is default
The matching of photosignal power threshold values, capacitance signal changing value are more than default electric capacity detection threshold values, there is impedance path；
Wherein, it can complete to instruct liquid absorbing probe part using one kind in the situation of change got at first as foundation
Stop liquid level test campaign, complete imbibition.
In above-mentioned S102, the setting of the strong and weak threshold values of the optical signal is specially：The height of liquid absorbing probe member distance liquid level
There is corresponding relation with light signal strength, such as need liquid absorbing probe part stop when resting on height default apart from liquid level test,
Complete imbibition, then the default highly corresponding light signal strength is the strong and weak threshold values of optical signal.
In above-mentioned S102, the setting of the electric capacity detection threshold values is specially：Different volumes treat that the capacitance of imbibition is different, inhale
The suction sample mouth of liquid probe member contacts the overlap capacitance value difference produced rear moment, and correspondingly, overlap capacitance value is corresponding
Shake frequency different；Such as need liquid absorbing probe part to be touched in its suction sample mouth and treat that the moment of imbibition stops test, completion imbibition, that
The changing value of the corresponding concussion frequency of the overlap capacitance value and blank reference frequency that are detected is electric capacity detection threshold
Value.
Electric-resistivity method pattern, capacitance method pattern, photoelectric method pattern are combined by above-described embodiment, while being applied to a set of liquid level
In detection device, the low defect of single detection pattern reliability is solved.Although current single use electric-resistivity method pattern, capacitance method
Prior art when pattern, photoelectric method pattern, but the technical scheme that above-mentioned pattern is combined by the embodiment of the present invention still possesses wound
The property made, reason for this is that：
It is due to that the early front volume of photoelectric sensor is larger, it is impossible to be embedded into sample-adding although the 1, photodetection is probably already existed
In pin, it can not be realized in production technology, so the technology is not used for detecting liquid level always；The above embodiment of the present invention is by inciting somebody to action
The structures such as photoelectricity radome 142, are successfully incorporated into imbibition needle tubing 11 by photoelectric sensor 141, finally realize photoelectric sensor
Application in detecting liquid level；
2nd, photoelectric sensor is easily disturbed by periphery external stray light, or even operating personnel walk about can all bring very big shadow
Ring, these technologies can not overcome, the present embodiment is using microcontroller chip control photoemission end 1411, and opto-electronic receiver end 1412 is defeated
The pulsewidth square wave for going out a coincidence pulse and different duty goes to driving photoemission end 1411, return the pulse signal that receives with
When the pulse of transmitting, pulse width signal are consistent, control system is it is confirmed that for liquid investigative range, rather than external interference, the i.e. present invention
Embodiment liquid detection device possesses judgement, discharges the function of external interference；
3rd, because different samples, reagent color are different, reflection efficiency is also different, causes to be very difficult to judge；Therefore, above-mentioned reality
Apply a detection method and first set different according to different samples also in full-automatic specific protein analyzer in implementation process
Feedback signal strength threshold values, then counted by coincidence pulse, the technical parameter such as pulsewidth come the distance of judgement sample so that overcome with
Upper technological difficulties.
It should be noted that the preferred embodiment of the present invention is given in the specification and its accompanying drawing of the present invention, still,
The present invention can be realized by many different forms, however it is not limited to the embodiment described by this specification, these embodiments
There is provided the purpose of these embodiments it is to make the understanding to the disclosure not as the extra limitation to present invention
It is more thorough comprehensive.Also, above-mentioned each technical characteristic continues to be mutually combined, the various embodiments not being enumerated above are formed,
It is considered as the scope of description of the invention record；Further, for those of ordinary skills, can be according to the above description
Improved or converted, and all these modifications and variations should all belong to the protection domain of appended claims of the present invention.
Claims (10)
1. a kind of liquid detection device (100) being loaded suitable for glycosylated hemoglobin, it is characterised in that including：Liquid absorbing probe
Part (10), sample arm (20), motion control mechanism (30), control circuit module (40)；Wherein,
The liquid absorbing probe part (10), for gathering and output capacitance, resistance, optical signal, pipette samples；
The sample arm (20), is connected with the liquid absorbing probe part (10), for driving the liquid absorbing probe part (10) complete
Drawn into sample；
The motion control mechanism (30), is connected with the sample arm (20), for controlling the sample arm (20) in level side
Motion on to, vertical direction；
The control circuit module (40), electric capacity, resistance, optical signal for receiving liquid absorbing probe part (10) output,
And control motion control mechanism (30) makes it drive sample arm (20) to move in the horizontal direction, in vertical direction accordingly.
2. the liquid detection device (100) according to claim 1 being loaded suitable for glycosylated hemoglobin, its feature exists
In, the liquid absorbing probe part (10), including imbibition needle tubing (11) and the electric capacity probe portion on the imbibition needle tubing (11)
(12), impedance part (13), photodetection portion (14), the electric capacity probe portion (12), impedance part (13), photodetection portion (14) edge
Imbibition needle tubing (11) y direction is successively away from imbibition needle tubing (11) the liquid sucting port end.
3. the liquid detection device (100) according to claim 2 being loaded suitable for glycosylated hemoglobin, its feature exists
In the electric capacity probe portion (12) is the capacitive suction sample mouth of imbibition needle tubing (11).
4. the liquid detection device (100) according to claim 2 being loaded suitable for glycosylated hemoglobin, its feature exists
In the impedance part (13) is arranged between the electric capacity probe portion (12) and the photodetection portion (14), described to surround
The metal body of imbibition needle tubing (11).
5. the liquid detection device (100) according to claim 2 being loaded suitable for glycosylated hemoglobin, its feature exists
In the photodetection portion (14) includes bar shape photoelectricity radome (142) and is arranged at photoelectricity radome (142) bottom
Photoelectric sensor (141), imbibition needle tubing (11) along y direction run through the photoelectricity radome (142) and liquid sucting port end part
It is exposed.
6. the liquid detection device (100) according to claim 1 being loaded suitable for glycosylated hemoglobin, its feature exists
In the motion control mechanism (30) includes horizontal movement control piece (31) and vertical movement control piece (32).
7. the liquid detection device (100) according to claim 1 being loaded suitable for glycosylated hemoglobin, its feature exists
In the control circuit module (40) includes current-to-voltage converting circuit, operational amplifier, voltage comparator, microprocessor, resistance
Hold and receive concussion finishing circuit.
8. a kind of detecting liquid level method being loaded suitable for glycosylated hemoglobin, it is characterised in that comprise the following steps：
S101, while liquid absorbing probe part does test campaign, keeps synchronous acquisition optical signal, capacitance signal, resistance signal
State；
S102, receives the optical signal, capacitance signal, resistance signal, and instruct imbibition to visit according to the situation of change of the signal
Needle part stops test campaign, completes imbibition；The situation of change of the signal is specifically included：Optical signal is strong and weak to be believed with default light
Number strong and weak threshold values matching, capacitance signal changing value are more than default electric capacity detection threshold values, there is impedance path；
Wherein, instruction liquid absorbing probe part can be completed by foundation of one kind in the situation of change got at first to stop
Liquid level test campaign, completion imbibition.
9. the detecting liquid level method according to claim 8 being loaded suitable for glycosylated hemoglobin, it is characterised in that S102
In, the setting of the strong and weak threshold values of the optical signal is specially：The height of liquid absorbing probe member distance liquid level exists with light signal strength
Corresponding relation, such as needs liquid absorbing probe part to stop test when resting on height default apart from liquid level, complete imbibition, then this is pre-
If the corresponding light signal strength of height be the strong and weak threshold values of optical signal.
10. the detecting liquid level method according to claim 8 being loaded suitable for glycosylated hemoglobin, it is characterised in that
In S102, the setting of the electric capacity detection threshold values is specially：Different volumes treat that the capacitance of imbibition is different, liquid absorbing probe part
The overlap capacitance value difference that sample mouth contacts moment generation is inhaled, correspondingly, the corresponding concussion frequency of overlap capacitance value is different；Such as
Need liquid absorbing probe part to be touched in its suction sample mouth and treat that the moment of imbibition stops test, completion imbibition, then the institute detected
The changing value for stating the corresponding concussion frequency of overlap capacitance value and blank reference frequency is electric capacity detection threshold values.
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| CN201710216701.2A CN107152953B (en) | 2017-04-01 | 2017-04-01 | Liquid level detection method and device suitable for sample adding of glycosylated hemoglobin |
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| CN201710216701.2A CN107152953B (en) | 2017-04-01 | 2017-04-01 | Liquid level detection method and device suitable for sample adding of glycosylated hemoglobin |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111279198A (en) * | 2017-12-15 | 2020-06-12 | 株式会社日立高新技术 | Automatic analyzer |
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| JPS62163968A (en) * | 1986-01-16 | 1987-07-20 | Nitsuteku:Kk | Pipet for confirming liquid amount and liquid amount confirming method and apparatus using said pipet |
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| CN102478417A (en) * | 2010-11-25 | 2012-05-30 | 上海安彩智能技术有限公司 | Liquid level detection device for sample addition system |
| CN203274849U (en) * | 2013-05-28 | 2013-11-06 | 深圳市希莱恒医用电子有限公司 | Liquid level detection device applied to medical detection instrument |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS62163968A (en) * | 1986-01-16 | 1987-07-20 | Nitsuteku:Kk | Pipet for confirming liquid amount and liquid amount confirming method and apparatus using said pipet |
| CN1169779A (en) * | 1995-04-11 | 1998-01-07 | 准确系统科学株式会社 | Liquid suction examination method and dispensation apparatus drive-controlled by the same |
| CN102478417A (en) * | 2010-11-25 | 2012-05-30 | 上海安彩智能技术有限公司 | Liquid level detection device for sample addition system |
| CN203274849U (en) * | 2013-05-28 | 2013-11-06 | 深圳市希莱恒医用电子有限公司 | Liquid level detection device applied to medical detection instrument |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111279198A (en) * | 2017-12-15 | 2020-06-12 | 株式会社日立高新技术 | Automatic analyzer |
| CN111279198B (en) * | 2017-12-15 | 2021-07-06 | 株式会社日立高新技术 | Automatic analyzer |
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| CN107152953B (en) | 2019-12-10 |
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