CN116242994B

CN116242994B - Household blood routine automatic analyzer

Info

Publication number: CN116242994B
Application number: CN202211576825.9A
Authority: CN
Inventors: 陈瑜; 杨艳; 陈文�; 韩彦博; 赵恬静
Original assignee: 8th Medical Center of PLA General Hospital
Current assignee: 8th Medical Center of PLA General Hospital
Priority date: 2022-12-09
Filing date: 2022-12-09
Publication date: 2023-10-13
Anticipated expiration: 2042-12-09
Also published as: CN116242994A

Abstract

The invention discloses a household blood routine automatic analyzer, comprising: the analyzer body is internally provided with a blood sample detection mechanism; the sampling assembly comprises a sampling matrix, a sampling sleeve, a puncture needle, a blood sample collecting channel and a blood sample test tube are arranged on the sampling matrix; the side wall of the sampling sleeve is provided with a sampling through hole, the puncture needle can move up and down in the sampling through hole, the blood sample collecting channel is arranged at the side of the puncture needle, and the blood sample test tube is communicated with the blood sample collecting channel and is used for collecting blood samples; the separation mixing assembly is arranged in the analyzer body and is provided with a fixing groove matched with the blood sample test tube, and the separation mixing assembly can drive the blood sample test tube to vibrate or rotate. The invention has the advantages of high blood sampling convenience, good safety, strong stability and low noise, and is particularly suitable for families.

Description

Household blood routine automatic analyzer

Technical Field

The invention belongs to the technical field of medical treatment, and particularly relates to a household blood routine automatic analyzer.

Background

Blood routine is a test for judging blood conditions and diseases by observing the number change and morphological distribution of blood cells, and is accomplished by machine detection with the development of modern and automatic tests. Many specific indexes in blood routine are commonly used sensitive indexes, and are sensitive to many pathological changes in the body. In addition, blood routine examination is a common indicator of observed effects of treatment, medication or withdrawal, continued or discontinued treatment, recurrence of disease, or recovery.

Traditional blood analysis requires taking a blood sample, analyzing the blood sample in detail, and reporting the blood sample, which consumes much time in the middle process. In addition, the conventional blood detecting instrument has the advantages of complex structure, inconvenient operation, large occupied space and being not suitable for the patients to use in home.

The patent of US10730043B2 provides a device for extracting a trace amount of a sample in a state suitable for a subsequent inspection without using an absorber or a chemical solution even when the trace amount of the sample is extracted; provided is an instrument which can extract blood suitable for subsequent blood tests even when a trace amount of peripheral blood that replaces arm venous blood is used as a sample; also provided is a microscale sample extraction separator for measuring a microscale peripheral blood as a sample with good accuracy by using a conventional reagent and analytical instrument. The present invention provides a sample extraction separator, comprising: a sample extractor having a sample extraction unit that uses capillary phenomenon; and a sample storage device having a storage mechanism into which the sample extractor can be inserted, wherein the sample extractor into which the sample is extracted is integrated into the sample storage device, thereby enabling centrifugal separation, storage, and transportation, and collecting the target sample after the centrifugal separation.

The invention patent of US10758652B2 provides a system and method for collecting plasma, the system comprising: venous access device for drawing whole blood from a subject and returning blood components to the subject; a blood component separation device for separating the drawn blood into a plasma component and a second blood component, the blood component separation device having an outlet and configured to transfer the plasma component to a plasma container; a liquid suction line fluidly connected to the venous access device and configured to deliver the sucked whole blood to the blood component separation device, the flow through the blood suction line being controlled by a blood suction pump; an anticoagulant line connected to an anticoagulant source, the anticoagulant line configured to introduce an anticoagulant into the aspirated whole blood; and a controller configured to control operation of the centrifuge bowl and the blood draw pump.

By analyzing the prior art, the existing blood analyzer is complex in structure, complex in sampling operation, high in professional requirements, long in blood sample analysis time consumption, complex in equipment, difficult to operate and not suitable for families.

Disclosure of Invention

The invention aims to provide a household blood routine automatic analyzer with high blood sampling convenience, good safety, strong stability and low noise.

The technical scheme adopted by the invention for achieving the purpose is as follows:

a home blood routine automatic analyzer comprising:

the analyzer body is internally provided with a blood sample detection mechanism;

the sampling assembly comprises a sampling matrix, wherein the sampling matrix is detachably arranged at the top of the analyzer body, and is provided with a sampling sleeve, a puncture needle, a blood sample collecting channel and a blood sample test tube which are matched with fingers; the sampling sleeve is horizontally arranged, a sampling through hole is formed in the side wall of the sampling sleeve, the puncture needle can move up and down in the sampling through hole, the blood sample collecting channel is arranged at the side of the puncture needle, and the top opening of the blood sample collecting channel is communicated with the sampling through hole; the top of the blood sample test tube is communicated with the blood sample collecting channel and is used for collecting blood samples;

the separation mixing assembly is arranged in the analyzer body and is provided with a fixing groove matched with the blood sample test tube, and the separation mixing assembly can drive the blood sample test tube to vibrate or rotate.

Further, the bottom of sampling base member is provided with the connecting piece, and the connecting piece can be with the detachable cooperation of separation mixing assembly.

Further, the blood sample test tube is arranged in the fixed groove, and after the sampling matrix is connected with the separation mixing assembly through the connecting piece, the bottom of the blood sample collecting channel is arranged opposite to the blood sample test tube.

Further, the blood sample detection mechanism is provided with a blood sensing device, a central processing unit, a data transmission module and a display screen, and the central processing unit is respectively connected with the blood sensing device, the data transmission module and the display screen.

Further, the data transmission module is connected with a Wifi module, and the data transmission module is in data communication with an external terminal through Wifi signals.

Further, a printer is provided on the analyzer body. The printer is connected with the central processing unit.

By adopting the technical scheme, when blood routine analysis is needed, fingers are stretched into the sampling sleeve, finger bellies are kept downwards, the finger bellies are placed on the through holes, the fingers are punctured upwards through the puncture needles, blood is convenient to flow out, and the flowing blood is collected through the blood sample collecting channel and discharged into the blood sample test tube. The operation risk that the specialty that exists that can avoid vein blood sampling to exist is too strong can be avoided through the finger collection blood, and the blood sampling portability is high, and ordinary patient also can realize taking blood by oneself under the circumstances that does not have other people to can reduce the use degree of difficulty of the conventional automatic analysis appearance of domestic blood, facilitate promotion and application. The collected blood sample can be mixed or separated by the separation mixing component, and the mixed blood can be subjected to blood routine detection by the blood sensing device of the blood sample detection mechanism. In addition, the blood sample can be centrifugally separated through the separation mixing component, and the biochemical index can be detected by utilizing the blood sample detection mechanism in the analyzer body, so that a user can know the physiological condition of the body conveniently, and further pathological analysis is facilitated.

The detected original data can be displayed on a display screen after being analyzed by the central processing unit, and the detection result can be printed by a printer, so that the subsequent analysis is convenient. And the central processing unit control can also be in data connection with a remote terminal, such as a remote computer system, through the Wifi module, and the remote terminal can quickly make diagnosis according to the original data. The analysis results not only enable the user to directly observe the record in the home, but also feed back to the hospital through the Internet.

According to one embodiment of the invention, a first sensor and a compression block are arranged in the sampling sleeve, and the first sensor is connected with a controller and is used for detecting whether a finger enters the sampling sleeve or not; the lateral side of sample cover inside is located to the compact heap, and the direction round trip movement of compact heap towards the sample cover center can be controlled to the controller.

Further, the compaction block is connected with the output end of the hydraulic rod.

Further, a pressure sensor is arranged on the side of the through hole, and the pressure sensor is connected with the controller.

From this, can monitor through first sensor whether the finger gets into the inside of sampling cover, after the accurate sample cover of putting into of finger, the controller can control the hydraulic stem and remove the compact heap, compress tightly the finger, avoid the finger to become flexible to slide, cause the damage of sampling process to finger portion musculature. After the compaction block compacts the finger, the controller detects whether the pressure sensor has a signal, judges whether the finger is correctly placed on the sampling through hole, and if the pressure sensor has a signal, the controller controls the puncture to be performed once for the finger, so that blood can flow out conveniently. Blood flows into the blood sample test tube through the blood sample collecting channel communicated with the sampling through hole, and blood sample collection is realized.

The finger is limited by controlling the compaction block, so that the expansion of the puncture wound at the end part of the finger caused by the finger displacement in the process of puncturing is avoided, and the sampling safety is improved. Through the design of compact heap, extrude the finger end at the in-process of taking a blood sample, can promote the outflow of blood after the puncture, improve blood collection effect and collection volume.

According to one embodiment of the present invention, the blood sample collection channel includes a first sampling channel, a second sampling channel, and a mixing channel, the bottoms of the first sampling channel and the second sampling channel each being in communication with the mixing channel.

The first sampling channel, the second sampling channel and the mixing channel are respectively detachably matched with the first sampling tube, the second sampling tube and the mixing tube, and the bottoms of the first sampling tube and the second sampling tube are communicated with the mixing tube.

Further, the first sampling tube, the second sampling tube, the mixing tube and the needle are all disposable. When the blood sampling device is used, the first sampling tube, the second sampling tube and the mixing tube are respectively inserted into the first sampling channel, the second sampling channel and the mixing channel, after the blood sample is sampled, the sampling assembly is moved out from the upper part of the separation mixing assembly, and the first sampling tube, the second sampling tube, the mixing tube and the like are taken out.

The bottom of the mixing channel is provided with a detachable needle head which is used for communicating the mixing tube with the blood sample test tube, and the needle head can move upwards and pierce the bottom of the mixing tube; the inside of the mixing tube is provided with an inclined screen plate, the side of the mixing tube is provided with a hydraulic push rod, and the hydraulic push rod is arranged above the inclined screen plate or is arranged opposite to the middle upper part of the upper surface of the inclined screen plate.

Thus, the blood collected by the finger is collected and discharged into the mixing tube through the first sampling tube and the second sampling tube, and then is input into the blood test tube in the separation mixing assembly through the needle head.

The mixing tube side sets up hydraulic push rod and can carry out extrusion to the mixing tube, can play the flow effect of promotion blood in first sampling tube, second sampling tube, promotes blood promptly and removes to the syringe needle direction from the finger tip fast, avoids the blood residue in first sampling tube and the second sampling tube.

The mixing tube is internally provided with the inclined screen plate, and the extrusion force can be applied to the direction of the inclined screen plate in the process of extruding the mixing tube by the hydraulic push rod, so that the downward flow of blood is facilitated, and the blood is prevented from flowing to the directions of the first sampling tube and the second sampling tube. Meanwhile, the air quantity in the region of the finger end is small because the finger end is pressed by the pressing block, and when the hydraulic rod presses the mixing tube, air is reduced or prevented from entering the blood sample test tube. In addition, the inclined screen plate also has a three-dimensional structure which is favorable for maintaining the mixing tube, so that the mixing tube can quickly recover the shape after being extruded.

According to one embodiment of the invention, the blood sample test tube is in an hourglass shape, the top opening end of the blood sample test tube is provided with a rubber sealing plug, the middle part of the side wall of the blood sample test tube is provided with a notch, and the notch is sealed by the rubber plug.

The blood sample test tube is hourglass form structure, can be comparatively effectual when the sample blood of assurance collection all gathers in the bottom of blood sample in vitro. The middle part side of blood sample test tube is equipped with a breach, can directly follow breach department extraction middle part medium or bottom medium like this, and during the detection, blood sample detection mechanism can directly follow the upper portion of blood sample test tube and the side respectively extract the medium of upper strata, middle level and carry out the analysis, improves the practicality.

Further, the edge of the notch is provided with a step part, and the periphery of the step part is provided with a positioning flange; one end of the rubber plug is provided with a sealing round table matched with the notch, the side wall of the rubber plug is provided with a positioning ring matched with the step part, and one end of the rubber plug far away from the sealing round table is provided with a positioning groove matched with the positioning flange.

Therefore, the connection tightness of the rubber plug and the notch can be improved, and the situation that the rubber plug falls off in the process that the blood sample test tube vibrates or rotates along with the separation mixing assembly is prevented.

Further, the blood sample test tube is filled with a certain amount of anticoagulant, and the inside of the blood sample test tube is in a negative pressure state.

According to one embodiment of the invention, the outer side of the blood sample test tube is sleeved with a protection tube, the outer wall of the blood sample test tube is sleeved with a limiting ring sleeve, and the outer side edge of the limiting ring sleeve is abutted with the inner wall of the protection tube; a positioning plug is arranged below the inside of the protection tube, and the bottom of the blood sample test tube is abutted with the positioning plug.

Therefore, the protection to the blood sample test tube can be enhanced through the protection tube, the impact of external collision to the blood sample test tube is prevented, and the leakage of the blood sample is prevented. The setting of spacing collar cover and location stopper can improve the stability and the straightness of blood sample test tube, prevents that blood sample test tube from rocking or inclining.

The top of protection pipe is equipped with the visor body, visor body and protection pipe threaded connection, and the middle part of visor body is equipped with the through-hole, and the through-hole cooperatees with the rubber sealing plug, and rubber sealing plug and through-hole butt seal the through-hole, and the one side that keeps away from the blood sample test tube on the visor body disposes the support siphunculus. Through the protection of visor body ability reinforcing to blood sample test tube top, maintain the three-dimensional structure of blood sample test tube, prevent to warp, avoid blood sample to reveal, can also avoid outside dust to get into the inside of protection tube, prevent the pollution, reduce outside temperature, light to the interference of blood sample.

The connecting pipe body comprises an outer pipe body and an inner pipe body which are coaxially sleeved, the bottom of the outer pipe body is fixedly connected with the bottom of the inner pipe body, the top of the outer pipe body is in threaded connection with the protection pipe, the top of the inner pipe body is connected with the bottom of the positioning plug, a compression spring is arranged between the inner pipe body and the outer pipe body, and the compression spring is connected with the bottom edge of the protection pipe.

In addition, the arrangement of the protection tube, the protection cover body and the connection tube body also has the functions of heat insulation and heat preservation, reduces the influence of the external environment on the blood sample, and avoids the coagulation of the blood sample.

The protective cover body is arranged, a buffer structure is formed above the blood sample test tube, a buffer space is enlarged, vibration generated in the process of connecting or separating the sampling assembly and the separation mixing assembly or impact generated in the process of connecting the mixing tube and the blood sample test tube by the needle head are weakened in the process of transmitting the energy to the blood sample test tube again through the protective cover body, and the stability of the blood sample test tube can be maintained.

The compression spring and other designs inside the connecting pipe body can reduce the influence of external vibration on the blood sample test tube, especially the blood sample test tube vibrates along with the separation mixing assembly or rotates the in-process, and the compression spring can reduce the protection tube and the blood sample test tube and loose structure because of rotatory rocking, helps keeping structural integrity, stability, and then can guarantee that the blood sample test tube can rotate or vibrate along with the separation mixing assembly in step to guarantee the separation or the mixing effect of its inside blood sample.

According to one embodiment of the invention, an auxiliary cover body is arranged on one side, far away from the protective tube, of the protective cover body, and the auxiliary cover body is in threaded connection with the protective cover body; one end of the supporting through pipe far away from the protective cover body is connected with the auxiliary cover body; the middle part of the auxiliary cover body is provided with a positioning ring groove which is arranged opposite to the supporting through pipe.

The protection of the protection tube and the blood sample test tube inside the protection tube is further improved through the auxiliary cover body. The positioning ring groove can be matched with the needle head, so that the accuracy of blood sample drainage is improved.

According to one embodiment of the invention, the separation and mixing assembly comprises a centrifugal matrix on which a plurality of fixing grooves are distributed in a circumferential array; the fixing grooves are generally provided in an even number to maintain structural stability during rotation.

A first motor is arranged below the centrifugal base body, and the first motor can drive the centrifugal base body to rotate; a second motor is arranged above the centrifugal matrix, a driving gear is arranged at the output end of the second motor, a driven gear is arranged in the fixed groove, and the driven gear is meshed with the driving gear; the blood sample test tube can be sleeved in the driven gear.

The stable matrix can be driven to rotate under the drive of the first motor, so that the protection tube and the blood sample test tube inside the protection tube can be subjected to centrifugal treatment, and separation of blood samples is facilitated. In particular, the blood sample test tube is hourglass form structure, and the upper portion of blood sample test tube just can be moved to in the in-process blood of centrifugation in-process blood rotation enough degree in the pipe, can effectively ensure centrifugal effect like this, and the supernatant that the centrifugation obtained can get rid of the region on blood sample test tube upper portion in the centrifugation in-process, and can not fall back to the below, has avoided the supernatant that the sample obtained to mix with going out the lower floor's medium after the centrifugation, guarantees centrifugal effect. The blood sample obtained after centrifugation can be used for detecting biochemical and pathological indexes of the blood sample.

The blood sample test tube can be connected with the driven gear through the external protection tube. Under the drive of the second motor, the driven gear drives the driven gear to rotate along with the rotation of the driving gear, so that the blood inside the blood sample test tube is fully mixed, especially the mixing of the blood and the anticoagulant in the blood sample test tube can be promoted, the layering or the coagulation of the blood sample is prevented, the conventional detection of the blood by using the whole blood is facilitated, and the accuracy of the detection result is ensured.

According to one embodiment of the invention, the separation and mixing assembly comprises a stabilizing matrix, a containing cavity is arranged in the stabilizing matrix, a centrifugal matrix is sleeved in the containing cavity, and an output end of the first motor penetrates through the stabilizing matrix and is connected with the bottom of the centrifugal matrix. The bottom of the accommodating cavity is provided with a sliding block which is arranged at the periphery of the centrifugal matrix; balls are arranged between the sliding blocks and the inner wall of the stable base body.

Therefore, the arrangement of the stable matrix plays a role in protecting and isolating the centrifugal matrix, so that the mutual influence of the stable matrix and other components of the analyzer body in the rotation process can be avoided, and the structural stability of the analyzer body is improved.

The centrifugal base body is rotated by arranging the balls and the sliding blocks, under the condition that the centrifugal base body rotates to shake, the sliding blocks contact with the sliding blocks at the bottom, the sliding blocks convert and transmit shaking force to the balls, shaking energy is consumed through rotation of the balls, shaking of the centrifugal base body is further reduced or avoided, the function of correcting the rotation process of the centrifugal base body to keep the rotation center in a controllable range is achieved, and rotation shaking noise can be reduced.

The centrifugal matrix is sleeved on the structure inside the stable matrix, so that a certain space is formed around the blood sample test tube, and the situation that the environmental heat cannot be dissipated and the blood sample in the blood sample test tube is influenced due to too small surrounding space can be avoided in the high-speed rotation process. Further, the side wall of the stable matrix can be provided with the heat dissipation holes, so that outward diffusion of heat generated in the rotation process of the centrifugal matrix can be promoted, dust particles in the air flow generated in the rotation process of the centrifugal matrix can be discharged, pollution of blood samples is avoided, and the dust particles are prevented from accumulating to influence the operation efficiency of the centrifugal matrix.

According to one embodiment of the invention, a plurality of limit jacks are distributed on the side wall of the stable base body in a circumferential array manner, limit plugs are arranged in the limit jacks, and limit flanges are arranged at two tail ends of each limit plug, which are arranged along the radial direction.

The setting of spacing jack and spacing inserted block can assist ball and sliding block to centrifugal matrix's rotation control on the one hand, and on the other hand can provide certain air flow space, the heat dissipation of being convenient for. In addition, the flow of internal dust particles outwardly with the airflow is also facilitated.

The invention relates to a household blood routine automatic analyzer with convenient blood collection and strong stability, which has the following beneficial effects:

1. The sampling sleeve, the puncture needle, the blood sample collecting channel and the blood sample test tube are arranged, and blood is collected by fingers, so that operation risks possibly existing in the condition of too strong specialty of venous blood collection can be avoided, and the blood collection convenience is improved;

2. the device has high use convenience, blood is sampled through the sampling assembly, then the separation mixing assembly is utilized to mix the blood sample, so that the conventional detection and analysis of the blood are conveniently carried out by utilizing the whole blood, the separation mixing assembly is utilized to centrifuge the blood sample to obtain supernatant, and the detection and analysis of biochemical and pathological indexes of the blood sample are conveniently carried out by utilizing serum;

3. the sampling matrix is provided with the first sensor, the compression block, the pressure sensor and the like which are matched with the controller, so that the accuracy of sampling can be improved, the puncture wound at the end part of a finger is prevented from being enlarged in the sampling process, and the sampling safety is improved;

4. the blood sample test tube is matched with the protection tube, the protection cover body and the connection tube body, so that the protection of the blood sample test tube is improved, the heat insulation effect is realized, and the separation or mixing effect of blood samples in the blood sample test tube can be ensured;

5. the stable matrix is matched with the centrifugal matrix, so that a heat dissipation space can be provided, the interaction between other parts in the analyzer and the centrifugal matrix can be weakened, and the dust removal effect is achieved;

6. The sliding block and the ball are arranged in the stable matrix, so that the shaking of the centrifugal matrix can be reduced or avoided, the function of correcting the rotation process of the centrifugal matrix and keeping the rotation center in a controllable range is achieved, and the rotation shaking noise can be reduced.

Drawings

FIG. 1 is a schematic view showing the overall structure of a conventional automatic analyzer for home blood according to embodiment 1 of the present invention;

FIG. 2 is a schematic view of a sampling assembly of the conventional automatic analyzer for home blood shown in FIG. 1;

FIG. 3 is a schematic view of the inner structure of the sampling sleeve shown in FIG. 2;

FIG. 4 is a schematic view of the blood collection passageway of the sampling assembly of FIG. 2 during a blood sampling procedure;

FIG. 5 is a schematic view of the separation and mixing assembly of the conventional automatic analyzer for home blood shown in FIG. 1;

FIG. 6 is a schematic view of the separation and mixing assembly of FIG. 5 at another angle;

FIG. 7 is a schematic view of the structure of the stabilization matrix shown in FIG. 6;

FIG. 8 is a schematic view of the assembled configuration of the separation and mixing assembly of FIG. 5;

FIG. 9 is a schematic view showing the structure of a blood sample tube according to example 2 of the present invention;

FIG. 10 is a schematic illustration of the mating of the blood sample tube of FIG. 9 with a protective tube;

FIG. 11 is an enlarged partial schematic view of portion A of FIG. 10;

FIG. 12 is an enlarged partial schematic view of portion B of FIG. 10;

FIG. 13 is a schematic view showing the structure of a separation and mixing assembly according to embodiment 3 of the present invention;

fig. 14 is a schematic view of the assembled structure of the separation and mixing assembly of fig. 13.

Reference numerals: an analyzer body 100; a blood sample detection means 101; a sampling assembly 10; sampling the substrate 11; a connecting member 12; a transitional connection matrix 13; a sampling sleeve 14; a sampling through hole 15; a first sensor 16; a pressing block 17; a hydraulic lever 18; a controller 19; a pressure sensor 20;

a puncture needle 30; a first sampling channel 31; a second sampling channel 32; a mixing channel 33; a first sampling tube 34; a second sampling tube 35; a mixing tube 36; a diagonal screen 37; a hydraulic pushrod 38; a needle 39;

a separate mixing assembly 40; centrifuging the substrate 41; a fixing groove 42; a stabilization base 43; a receiving chamber 44; a slide block 45; a ball 46; a limit jack 47; a limit insert 48; a limit flange 49; a first motor 51; a second motor 52; a drive gear 53; a driven gear 54;

a blood sample tube 60; a rubber sealing plug 61; notch 62; a step 63; positioning flange 64; a rubber plug 65; a sealing round table 66; a positioning ring 67; a positioning groove 68;

a protective tube 70; a stop collar sleeve 71; a positioning plug 72; a protective cover 80; a through hole 81; a support through pipe 82; an auxiliary cover 83; a detent ring groove 84; a connection pipe body 90; an outer tube 91; an inner tube 92; compressing the spring 93.

Detailed Description

The technical scheme of the invention is further described in detail below with reference to the detailed description and the accompanying drawings. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.

Example 1

Fig. 1 to 8 schematically show a conventional automatic analyzer for household blood according to an embodiment of the present invention. As shown in the figure, the device comprises an analyzer body 100, wherein a blood sample detection mechanism 101 is arranged in the analyzer body 100, so that the whole blood can be subjected to routine blood detection, and the serum can be subjected to biochemical index detection of the blood sample. The top of the analyzer body 100 is provided with a sampling assembly 10, a separation mixing assembly 40 is arranged below the sampling assembly 10, and a blood sample collected by the sampling assembly 10 can be subjected to subsequent treatment by the separation mixing assembly 40 and then transmitted to a blood sample detection mechanism 101 for detection by a manipulator and a transmission assembly.

The blood sample detection mechanism 101 is provided with a blood sensing device, a central processing unit, a data transmission module and a display screen, and the central processing unit is respectively connected with the blood sensing device, the data transmission module and the display screen. The data transmission module is connected with a Wifi module, and the data transmission module carries out data communication with an external terminal through Wifi signals. The analyzer body 100 is also provided with a printer. The printer is connected with the central processing unit.

The collected blood sample may be mixed or separated by the separation and mixing assembly 40, and the mixed blood may be subjected to routine blood testing by the blood sensing device of the blood sample testing mechanism 101. In addition, the blood sample can be centrifugally separated through the separation and mixing assembly 40, and the biochemical index can be detected by the blood sample detection mechanism 101 in the analyzer body 100, so that a user can know the physiological condition of the body conveniently, and further pathological analysis is facilitated.

Specifically, the sampling assembly 10 includes a circular sampling base 11, and the sampling base 11 is detachably disposed on the top of the analyzer body 100. The bottom of the sampling base 11 is provided with a connector 12 for plugging or separating with a separate mixing assembly 40 at the bottom. The connecting piece 12 can be arranged as a magnetic connecting block or a plug-in piece, and is convenient to detach, stable in connection and not easy to fall off.

The sampling base 11 is provided with a sampling hub 14 for engagement with a finger, a lancet 30, a blood sample collection channel and a blood sample tube 60.

The sampling sleeve 14 is a horizontally arranged circular sleeve structure, and the side wall of the downward sampling sleeve is provided with a sampling through hole 15. The sampling sleeve 14 is disposed above the sampling base 11 through the transition base 13, and an internal passage of the sampling sleeve 14 communicates with the inside of the sampling base 11 through the sampling through hole 15. During sampling, the finger is inserted into the sampling sleeve 14, the abdomen is kept downward, and the abdomen is placed on the sampling through hole 15.

The inside of the sampling sleeve 14 is provided with a first sensor 16 and a compression block 17, and the first sensor 16 is connected with a controller 19 for detecting whether a finger enters; the hold-down block 17 is arranged at the side of the inside of the sampling sleeve 14, and the hold-down block 17 is connected with the output end of the hydraulic rod 18. The controller 19 can control the hydraulic rod 18 to operate, and then drive the compressing block 17 to reciprocate towards the center of the sampling sleeve 14. A pressure sensor 20 is disposed on the side of the through hole 81, and the pressure sensor 20 is connected to the controller 19.

Whether the finger enters the sampling sleeve 14 or not can be monitored through the first sensor 16, after the finger is correctly placed in the sampling sleeve 14, the controller 19 can control the hydraulic rod 18 to move the compaction block 17 to compact the finger, so that the finger is prevented from loosening and slipping, and the damage to the muscle tissue of the finger in the sampling process is avoided. After the pressing block 17 presses the finger, the controller 19 detects whether the pressure sensor 20 has a signal, judges whether the finger is correctly placed on the sampling through hole 15, and if the pressure sensor 20 has a signal, the controller 19 controls the puncture needle 30 to puncture the finger once, so that blood can flow out conveniently.

The sampling sleeve 14, the transition connection matrix 13 and the sampling matrix 11 are internally provided with a communicated cavity, the puncture needle 30 is arranged in the cavity, the puncture needle 30 can move up and down in the sampling through hole 15, the blood sample collecting channel is arranged at the side of the puncture needle 30, and the top opening of the blood sample collecting channel is communicated with the sampling through hole 15; the top of the blood sample tube 60 communicates with the blood sample collection channel for collecting blood samples.

Specifically, the blood sample collection channel includes a first sampling channel 31, a second sampling channel 32 and a mixing channel 33, and the bottoms of the first sampling channel 31 and the second sampling channel 32 are communicated with the mixing channel 33. The first sampling channel 31, the second sampling channel 32 and the mixing channel 33 are detachably matched with the first sampling tube 34, the second sampling tube 35 and the mixing tube 36 respectively, and the bottoms of the first sampling tube 34 and the second sampling tube 35 are communicated with the mixing tube 36. The blood collected by the puncture needle 30 by puncturing the finger is collected by the first sampling tube 34 and the second sampling tube 35 and discharged into the mixing tube 36.

Wherein, the first sampling tube 34, the second sampling tube 35 and the mixing tube 36 are all disposable products. In use, the first sampling tube 34, the second sampling tube 35, and the mixing tube 36 are inserted into the first sampling channel 31, the second sampling channel 32, and the mixing channel 33, respectively, and after the blood sample is sampled, the sampling assembly 10 is removed from above the separation mixing assembly 40, and the first sampling tube 34, the second sampling tube 35, the mixing tube 36, and the like are taken out.

The mixing tube 36 is internally provided with an inclined screen plate 37, a hydraulic push rod 38 is arranged on the side of the mixing tube 36, and the hydraulic push rod 38 is arranged above the inclined screen plate 37 or opposite to the middle upper part of the upper surface of the inclined screen plate 37. The bottom of the mixing channel 33 is provided with a removable needle 39, the needle 39 also being disposable and being adapted to communicate the mixing tube 36 with the blood sample tube 60, the needle 39 being adapted to move upwards and pierce the bottom of the mixing tube 36 and thereby guide the blood sample in the mixing tube 36 into the interior of the blood sample tube 60.

The hydraulic push rod 38 is provided on the lateral side of the mixing tube 36 to squeeze the mixing tube 36, which can promote the flow of blood in the first and second sampling tubes 34 and 35, that is, promote the rapid movement of blood from the finger end to the needle 39, and avoid the residual blood in the first and second sampling tubes 34 and 35. The mixing tube 36 is internally provided with the inclined screen plate 37, and in the process of extruding the mixing tube 36 by the hydraulic push rod 38, extrusion force can be applied to the direction of the inclined screen plate 37, so that blood can flow downwards, and the blood can be prevented from flowing to the directions of the first sampling tube 34 and the second sampling tube 35.

The blood sample tube 60 is disposed in the stationary slot 42 of the separation and mixing assembly 40 to facilitate mixing or separation of the blood sample directly after sampling. The blood sample test tube 60 contains a certain amount of anticoagulant, and the interior of the blood sample test tube 60 is in a negative pressure state, so that after the mixing tube 36 is communicated with the interior of the blood sample test tube 60 through the needle 39, the blood sample can be conveyed under the action of air pressure, for example, the interior of the blood sample test tube 60 is mixed with the anticoagulant, and the blood can be prevented from remaining in the mixing tube 36.

The separation mixing assembly 40 is arranged in the analyzer body 100, and comprises a centrifugal matrix 41 and a stabilizing matrix 43, wherein the centrifugal matrix 41 is sleeved in the inner part of the analyzer body, the stabilizing matrix 43 is internally provided with a containing cavity 44, and the centrifugal matrix 41 is sleeved in the containing cavity 44. The arrangement of the stabilizing matrix 43 protects and isolates the centrifugal matrix 41, so that the stabilizing matrix can be prevented from affecting other components of the analyzer body 100 during rotation, and the structural stability of the analyzer body 100 is improved. A plurality of holding grooves 42 are distributed in a circumferential array on the centrifuge base 41 for receiving blood sample tubes 60. The fixing grooves 42 are generally provided in an even number to maintain structural stability during rotation.

The bottom of the stabilizing base 43 is provided with a first motor 51, and an output end of the first motor 51 penetrates through the stabilizing base 43 and is connected with the bottom of the centrifugal base 41 to drive the centrifugal base 41 to rotate. A second motor 52 is arranged above the centrifugal base 41, a driving gear 53 is arranged at the output end of the second motor 52, a driven gear 54 is arranged in the fixed groove 42, and the driven gear 54 is meshed with the driving gear 53; the blood sample tube 60 can be housed inside the driven gear 54.

The stabilization body 43 is rotated by the first motor 51, so that the protection tube 70 and the blood sample tube 60 inside the protection tube can be centrifuged to facilitate separation of the blood sample. The blood sample test tube 60 is connected with the driven gear 54, and driven by the second motor 52, the driven gear 54 can rotate along with the rotation of the driving gear 53, so that the blood inside the blood sample test tube 60 is fully mixed, especially the blood can be promoted to be mixed with the anticoagulant in the blood sample test tube 60, the blood sample is prevented from layering or coagulating, the conventional blood detection by using whole blood is facilitated, and the accuracy of the detection result is ensured.

The centrifugal matrix 41 is sleeved in the stable matrix 43, so that a certain space is provided around the blood sample test tube 60, and in the process of high-speed rotation, the phenomenon that the heat of the environment cannot be dissipated due to too small surrounding space, and the blood sample in the blood sample test tube 60 is affected can be avoided.

The bottom of the accommodating cavity 44 is provided with a sliding block 45, the sliding block 45 is arranged on the periphery of the centrifugal base 41, and balls 46 are arranged between the sliding block 45 and the inner wall of the stabilizing base 43. The ball 46 and the sliding block 45 are arranged to control the rotation of the centrifugal matrix 41, and under the condition that the centrifugal matrix 41 rotates to shake, the sliding block 45 contacts with the sliding block 45 at the bottom, the sliding block 45 converts and transmits shaking force to the ball 46, and shaking energy is consumed through the rotation of the ball 46, so that shaking of the centrifugal matrix 41 is reduced or avoided, the rotation process of the centrifugal matrix 41 is corrected, the rotation center is kept in a controllable range, and the rotation shaking noise can be reduced.

By adopting the conventional automatic analyzer for household blood in the embodiment, a user can perform detection and analysis of blood samples at home. When blood routine analysis is required, the finger is inserted into the sampling sleeve 14, the finger belly is kept downwards, the finger belly is placed on the through hole 81, the finger is pierced upwards through the piercing needle 30, blood is conveniently discharged, and the discharged blood is collected through the blood sample collecting channel and discharged into the blood sample test tube 60. The operation risk that the specialty that exists that can avoid vein blood sampling to exist is too strong can be avoided through the finger collection blood, and the blood sampling portability is high, and ordinary patient also can realize taking blood by oneself under the circumstances that does not have other people to can reduce the use degree of difficulty of the conventional automatic analysis appearance of domestic blood, facilitate promotion and application.

Example 2

Fig. 9 to 12 schematically show a conventional automatic analyzer for home blood according to another embodiment of the present invention, which is different from example 1 in that:

the blood sample tube 60 is hourglass-shaped and has a rubber sealing plug 61 disposed at its top open end. The blood sample test tube 60 just can move to the upper portion of blood sample test tube 60 in the in-process blood of centrifugation in-tube rotation enough degree, can effectively ensure centrifugal effect like this, and the supernatant that the centrifugation obtained can get rid of the region on blood sample test tube 60 upper portion at the centrifugation in-process, and can not fall back to the below, has avoided the supernatant that the sample obtained to mix with going out the lower floor medium after the centrifugation, guarantees centrifugal effect. The blood sample obtained after centrifugation can be used for detecting biochemical and pathological indexes of the blood sample.

The middle of the side wall of the blood sample test tube 60 is provided with a notch 62, and the notch 62 is sealed by a rubber plug 65. The blood sample tube 60 is of an hourglass-shaped structure, and can effectively ensure that collected blood is gathered at the bottom of the blood sample tube 60 during sampling. The middle side of the blood sample test tube 60 is provided with a notch 62, so that the middle medium or the bottom medium can be directly extracted from the notch 62, and when the blood sample test tube is tested, the blood sample testing mechanism 101 can directly extract the medium of the upper layer and the middle layer from the upper part and the side of the blood sample test tube 60 for analysis, thereby improving the practicability.

The edge of the notch 62 is provided with a step part 63, and the periphery of the step part 63 is provided with a positioning flange 64; one end of the rubber plug 65 is provided with a sealing round table 66 matched with the notch 62, the side wall of the rubber plug 65 is provided with a positioning ring 67 matched with the step part 63, and one end of the rubber plug 65 far away from the sealing round table 66 is provided with a positioning groove 68 matched with the positioning flange 64. In this way, the connection tightness between the rubber plug 65 and the notch 62 can be improved, and the situation that the rubber plug 65 falls off in the process that the blood sample test tube 60 vibrates or rotates along with the separation mixing assembly 40 is prevented.

The outside cover of blood sample test tube 60 is equipped with protection tube 70, and the top is equipped with protection lid 80, and the bottom is equipped with connecting tube 90, can strengthen the protection to blood sample test tube 60 to it insulates against heat and keeps warm, reduces the influence of external environment to inside blood sample. The blood sample tube 60 may be connected to the driven gear 54 by a protective tube 70 external thereto.

The protective tube 70 is internally provided with a limiting collar 71, the blood sample test tube 60 is sleeved in the limiting collar 71, and the outer edge of the limiting collar 71 is abutted with the inner wall of the protective tube 70. A positioning plug 72 is disposed at the middle lower part of the inside of the protection tube 70, and the bottom of the blood sample tube 60 abuts against the positioning plug 72. The arrangement of the stop collar 71 and the stop plug 72 can improve the stability and the verticality of the blood sample test tube 60 and prevent the blood sample test tube 60 from shaking or tilting.

The protection cover body 80 is in threaded connection with the protection tube 70, through holes 81 are formed in the middle of the protection cover body 80 and at the top of the protection tube 70, the through holes 81 are matched with the rubber sealing plug 61, the rubber sealing plug 61 is abutted to the through holes 81 and seals the through holes 81, and a supporting through tube 82 is arranged on one side, far away from the blood sample test tube 60, of the protection cover body 80. An auxiliary cover 83 is arranged on one side of the protective cover 80 away from the protective tube 70, and the auxiliary cover 83 is in threaded connection with the protective cover 80; one end of the supporting through pipe 82 far away from the protective cover 80 is connected with the auxiliary cover 83; the middle part of the auxiliary cover 83 is provided with a positioning ring groove 84, and the positioning ring groove 84 is arranged opposite to the supporting through pipe 82.

The arrangement of the protective cover 80 and the auxiliary cover 83 forms a buffer structure above the blood sample tube 60, and vibration generated during connection or disconnection of the sampling assembly 10 and the separation and mixing assembly 40 or impact generated during connection of the mixing tube 36 and the blood sample tube 60 by the needle 39, and energy is weakened during the process of being transferred to the blood sample tube 60 again through the protective cover 80, so that the stability of the blood sample tube 60 can be maintained. When taking a blood sample, the needle 39 is connected to the mixing tube 36 at one end, and the first end pierces the auxiliary cap 83 and extends downwards in the direction of the support tube 82 until it pierces the rubber sealing stopper 61 at the top of the blood sample tube 60.

The connecting pipe body 90 comprises an outer pipe body 91 and an inner pipe body 92 which are coaxially sleeved, the bottom of the outer pipe body 91 is fixedly connected with the bottom of the inner pipe body 92, the top of the outer pipe body 91 is in threaded connection with the protection pipe 70, the top of the inner pipe body 92 is connected with the bottom of the positioning plug 72, a compression spring 93 is arranged between the inner pipe body 92 and the outer pipe body 91, and the compression spring 93 is connected with the bottom edge of the protection pipe 70.

The compression spring 93 and other designs inside the connecting pipe body 90 can reduce the influence of external vibration on the blood sample test tube 60, especially in the process that the blood sample test tube 60 vibrates or rotates along with the separation mixing assembly 40, the compression spring 93 can reduce the structure looseness of the protection pipe 70 and the blood sample test tube 60 due to rotation and shaking, which is helpful for keeping the integrity and stability of the structure, and further can ensure that the blood sample test tube 60 can synchronously rotate or vibrate along with the separation mixing assembly 40, thereby ensuring the separation or mixing effect of blood samples inside.

Example 3

Fig. 13 and 14 schematically show a conventional automatic analyzer for home blood according to another embodiment of the present invention, which is different from example 1 in that:

a plurality of limit jacks 47 are distributed on the side wall of the stable base body 43 in a circumferential array manner, limit plugs 48 are arranged in the limit jacks 47, and limit flanges 49 are arranged at two tail ends of the limit plugs 48 which are arranged along the radial direction. The setting of spacing jack 47 and spacing inserted block 48 can assist ball 46 and slider 45 on the one hand to centrifugal matrix 41's rotation control, and on the other hand can provide certain air flow space, the heat dissipation of being convenient for. In addition, the flow of internal dust particles outwardly with the airflow is also facilitated.

Conventional operations in the operation steps of the present invention are well known to those skilled in the art, and are not described herein.

While the foregoing embodiments have been described in detail in connection with the embodiments of the invention, it should be understood that the foregoing embodiments are merely illustrative of the invention and are not intended to limit the invention, and any modifications, additions, substitutions and the like made within the principles of the invention are intended to be included within the scope of the invention.

Claims

1. A home blood routine automatic analyzer, comprising:

an analyzer body (100), wherein a blood sample detection mechanism (101) is arranged inside the analyzer body (100);

the sampling assembly (10) comprises a sampling matrix (11), wherein the sampling matrix (11) is arranged at the top of the analyzer body (100), and the sampling matrix (11) is provided with a sampling sleeve (14), a puncture needle (30), a blood sample collecting channel and a blood sample test tube (60); the side wall of the sampling sleeve (14) is provided with a sampling through hole (15), the puncture needle (30) can move up and down in the sampling through hole (15), the blood sample collecting channel is arranged at the side of the puncture needle (30), and the blood sample test tube (60) is communicated with the blood sample collecting channel and is used for collecting blood samples;

A separation and mixing assembly (40) arranged inside the analyzer body (100), wherein the separation and mixing assembly (40) is provided with a fixing groove (42) matched with the blood sample test tube (60), and the separation and mixing assembly (40) can drive the blood sample test tube (60) to vibrate or rotate;

the blood sample collection channel comprises a mixing channel (33), and the mixing channel (33) and a mixing tube (36) are detachably matched; the bottom of the mixing channel (33) is provided with a detachable needle (39) for communicating the mixing tube (36) with the blood sample test tube (60); an inclined screen plate (37) is arranged in the mixing pipe (36), and a hydraulic push rod (38) is arranged on the side of the mixing pipe (36).

2. The home-use blood routine automatic analyzer of claim 1, wherein,

the inside of the sampling sleeve (14) is provided with a first sensor (16) and a compression block (17), and the first sensor (16) is connected with a controller (19) and is used for detecting whether a finger enters; the compressing block (17) is arranged at the side of the inside of the sampling sleeve (14), and the controller (19) can control the compressing block (17) to reciprocate towards the center of the sampling sleeve (14).

3. The home-use blood routine automatic analyzer of claim 1, wherein,

the blood sample collection channel comprises a first sampling channel (31) and a second sampling channel (32), wherein the first sampling channel (31) and the second sampling channel (32) are communicated with the mixing channel (33);

the first sampling channel (31) and the second sampling channel (32) are respectively detachably matched with the first sampling tube (34) and the second sampling tube (35), and the first sampling tube (34) and the second sampling tube (35) are respectively communicated with the mixing tube (36).

4. The home-use blood routine automatic analyzer of claim 1, wherein,

the blood sample test tube (60) is hourglass form, the open top of blood sample test tube (60) is provided with rubber sealing plug (61), the middle part of blood sample test tube (60) lateral wall is equipped with breach (62), breach (62) are sealed through plug (65).

5. The home-use blood routine automatic analyzer of claim 4, wherein,

the outer side of the blood sample test tube (60) is sleeved with a protection tube (70), the outer wall of the blood sample test tube (60) is sleeved with a limiting ring sleeve (71), and the outer side edge of the limiting ring sleeve (71) is abutted with the inner wall of the protection tube (70); a positioning plug (72) is arranged in the protection tube (70), and the bottom of the blood sample test tube (60) is abutted with the positioning plug (72);

The top of the protection tube (70) is provided with a protection cap body (80), the middle part of the protection cap body (80) is provided with a through hole (81), the through hole (81) is matched with the rubber sealing plug (61), one side, far away from the blood sample test tube (60), of the protection cap body (80) is provided with a supporting through tube (82), and the tail end of the supporting through tube (82) is sealed;

the bottom of blood sample test tube (60) is equipped with connecting pipe body (90), connecting pipe body (90) are including outer body (91) and interior body (92) that the coaxial cover was established, the bottom of outer body (91) with the bottom fixed connection of interior body (92), the top of outer body (91) with protection tube (70) are connected, the top of interior body (92) with the bottom of location stopper (72) links to each other, interior body (92) with dispose compression spring (93) between outer body (91), compression spring (93) with the bottom edge of protection tube (70) links to each other.

6. The home-use blood routine automatic analyzer of claim 5, wherein,

an auxiliary cover body (83) is arranged on one side, far away from the protective tube (70), of the protective cover body (80), and the auxiliary cover body (83) is in threaded connection with the protective cover body (80); one end of the supporting through pipe (82) far away from the protective cover body (80) is connected with the auxiliary cover body (83); the middle part of the auxiliary cover body (83) is provided with a positioning ring groove (84), and the positioning ring groove (84) is arranged opposite to the supporting through pipe (82).

7. The home-use blood routine automatic analyzer of claim 1, wherein,

the separation and mixing assembly (40) comprises a centrifugal base body (41), wherein a plurality of fixing grooves (42) are distributed on the centrifugal base body (41) in a circumferential array;

a first motor (51) is arranged below the centrifugal base body (41), and the first motor (51) can drive the centrifugal base body (41) to rotate; a second motor (52) is arranged above the centrifugal base body (41), a driving gear (53) is arranged at the output end of the second motor (52), a driven gear (54) is arranged in the fixed groove (42), and the driven gear (54) is meshed with the driving gear (53); the blood sample test tube (60) can be sleeved inside the driven gear (54).

8. The home-use blood routine automatic analyzer of claim 7, wherein,

the separation mixing assembly (40) comprises a stabilizing matrix (43), a containing cavity (44) is formed in the stabilizing matrix (43), the centrifugal matrix (41) is sleeved in the containing cavity (44), and the output end of the first motor (51) penetrates through the stabilizing matrix (43) and is connected with the bottom of the centrifugal matrix (41);

A sliding block (45) is arranged at the bottom of the accommodating cavity (44), and the sliding block (45) is arranged at the periphery of the centrifugal base body (41); a ball (46) is arranged between the sliding block (45) and the inner wall of the stabilizing base body (43).

9. The home-use blood routine automatic analyzer of claim 8, wherein,

a plurality of limit jacks (47) are distributed on the side wall of the stable base body (43) in a circumferential array mode, limit plugs (48) are arranged in the limit jacks (47), and limit flanges (49) are arranged at two tail ends of each limit plug (48) in the radial direction.