CN101603968A - The closed automatic detection device of blood rheology measurement - Google Patents
The closed automatic detection device of blood rheology measurement Download PDFInfo
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- CN101603968A CN101603968A CNA2009103043296A CN200910304329A CN101603968A CN 101603968 A CN101603968 A CN 101603968A CN A2009103043296 A CNA2009103043296 A CN A2009103043296A CN 200910304329 A CN200910304329 A CN 200910304329A CN 101603968 A CN101603968 A CN 101603968A
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Abstract
The invention discloses a kind of closed automatic detection device of blood rheology measurement, comprise the test tube rack supporting plate, barcode scanner, the test tube rack mobile device, the blood sample automatic conveyor of test tube rack monitoring position device, comprise sampling/surveyingpin assembly, the inserting needle drive unit, the quantitative sampling controller, upper sphere, heating component, cleaning device, the sampling and measuring system of station conversion driving device, comprise flexible clamping device, flexible clamping device rotation drive motor, move up and down device, the evenly mixing device of horizontally moving device, and air pump, single-chip microcomputer etc., it can make blood rheology measurement realize the automatic transmission of blood sample under covered state, blood sample put upside down evenly mixing device automatically, the automatic ration sampling, automatically measure blood sample, automatically clean measurement mechanism, automatically identification, record, realize the automatic down blood viscosity of measuring of full closeding state, can avoid cross pollution, can alleviate staff's labour intensity again, improve measurement effect, can also shorten Measuring Time.
Description
Technical field
The present invention relates to blood measuring device field, particularly a kind of and blood viscosity are measured the closed automatic detection device of relevant blood rheology measurement.
Background technology
Blood viscosity is the most important index that characterizes rheological characteristics of blood and the Changing Pattern under physiology and pathological conditions thereof on the clinical medicine, and it comprises whole blood viscosity and plasma viscosity two aspects, is called for short hemorheology usually.The mensuration of blood viscosity parameter, to understanding the mobile of blood and the Changing Pattern under physiology and pathological conditions thereof, diagnosis and control are significant because of the disease that blood viscosity causes unusually.The instrument kind of measuring blood viscosity has multiple, wherein with simple to operate, to measure the use quick and capillary viscosimeter that price is lower comparatively general.The capillary viscosimeter that generally adopts as shown in Figure 8 at present: be made up of pressure transducer A, upper sphere B, kapillary measuring body C, lower sphere D, pump valve group E, single tube suction needle F, washer bottle G, heating wire constant temperature heating device H and connecting line, measured's blood sample is contained in the test tube.When doing the whole blood viscosity measurement, the staff shakes up blood in the test tube earlier with hand, the test tube mouth of pipe after then blood being shaken up upwards is placed on the fixed mount of pick-up unit, the single tube suction needle is inserted the blood from the test tube mouth that opens wide, start the pump valve group, under the control of pump valve group, the single tube suction needle passes through negative pressure draw blood sample in lower sphere, utilize the other heating wire constant temperature heating device of lower sphere that blood preparation is preheated to 37 ℃ earlier, again the blood preparation after the preheating is drawn in the upper sphere, when the upper sphere internal pressure reaches threshold value, make by the pump valve group, it is poor to form positive pressure between lower sphere, and blood preparation flow back into lower sphere by upper sphere from the kapillary measuring body, the flow through process of kapillary measuring body of blood preparation, pressure transducer writes down pressure history simultaneously, thereby obtains the blood flow variate.After the measurement, blood preparation is discharged from the single tube suction needle, by the pump valve group cleaning fluid in the washer bottle is drawn in the lower sphere then, is drawn in the upper sphere again, allow wash liquid stream clean, the waste liquid after cleaning from the discharge of single tube suction needle at last through the kapillary measuring body.When doing plasma viscosity and measure, earlier with the blood preparation surveyed through after centrifugal, allow red blood cell be deposited in test tube lower floor, blood plasma is positioned at the test tube upper strata, by artificial elder generation blood plasma is extracted separately and places, and measures then, with the accuracy that guarantees to measure.Process that it is measured by the kapillary measuring body and cleaning process and whole blood are measured similar.This shows that conventional apparatus has many shortcomings: at first, blood preparation must be drawn from open test tube.For the situation that current most of hospitals use the vacuum test tube of sealing to take a blood sample, many operations of manually uncapping together, and make the operator face the threat of cross pollution.And each suction amount is inconsistent, influence measurement result, and measurement and detergent line are long, makes increase consuming time; Secondly, the mixing sample has increased workload by hand, has further prolonged Measuring Time; Once more, when carrying out the plasma viscosity measurement, the operator more needs careful control operation, and the careless slightly measurement result that just may make is inaccurate, and blood preparation also must carry out centrifugal again.Long at measurement, cleaning route that traditional kapillary measuring method of measuring hemorheology exists, opening wide sampling causes polluting easily, the manual mixing blood preparation long problem that influences measurement result that waits consuming time, publication number be CN1808097A's " a kind of method of quick measurement blood viscosity " a kind of technical scheme of quick measurement blood viscosity is disclosed, wherein relate to a kind of measurement mechanism that uses kapillary to measure blood viscosity, this measurement mechanism is made up of measurement main body, sampling system, purging system, mixing mechanism.Glass spheres, the capillary measuring tube of measuring main body connect by a Square Connector, on the kapillary outer wall sleeve pipe is housed, between sleeve pipe top and the connector pore is arranged, there is an opening sleeve pipe below apart from the about 7cm of injection port place, pore and opening formation air flue are used for adding gases at high pressure and carry out sample introduction, or logical atmosphere is sampled.The main planker front end of sample introduction mechanism is equipped with displacement transducer and taper steady arm, this steady arm top is connected with Washing cup, on the main planker screw mandrel is installed, the axis of guide and the gear train that can move up and down, Washing cup and steady arm are installed in screw mandrel supporting seat upper end, sample introduction mechanism moves downward drive measurement main body by motor-driven and moves downward, the measurement body front end is thrust in the interior liquid of vacuum test tube, and by in vacuum test tube, being pressed into gases at high pressure from the sleeve pipe air flue, make liquid from capillary flow to glass spheres, after the rising of measurement spheroid internal pressure reaches setting value, quit work solenoid valve in the coincidence circuit of air pump is opened with atmosphere and is communicated with in the air flue loop, and micro-pressure sensor begins sampling and calculates and be saved in the database.Move upward when measuring main body, measuring head arrives in the Washing cup, and the scavenging pump of glass spheres top begins to the spheroid intracontour waterflooding, and water enters in the Washing cup by kapillary, cleans laggard model machine structure and moves upward, and taper steady arm and vacuum test tube disengage.The Washing cup of wiper mechanism respectively has a pilot seal part up and down, and below pilot seal part is equipped with the taper steady arm, and pilot seal part, taper steady arm centre bit are equipped with a circular hole, and there is a water inlet on the cup upper left side, and there is a freeing port lower right.Mixing mechanism has a pallet to become miter angle with surface level, there is the pallet axle at the pallet center, the pallet axle is equipped with follower gear and generator shaft gear engagement, tray edge is provided with the hole of a plurality of fixedly vacuum test tubes, and vacuum test tube is put into the pallet hole, rotates by pallet, vacuum test tube is moved with pallet around the pallet axle, because pallet becomes miter angle with surface level, so vacuum test tube can form the variation of an angle of 90 degrees when axially moving with pallet, thus the blood sample in the vacuum test tube is carried out mixing.The device of this quick measurement blood viscosity; can shorten measurement; the route that cleans; and can carry out closed sample introduction; can avoid cross pollution; but owing to need a collection of installation vacuum test tube on the pallet; when being installed, vacuum test tube shuts down by fixing in the pallet hole of manually vacuum test tube being inserted one by one wiper mechanism; with shutting down vacuum test tube is taken off one by one; can't implement device uninterrupted replacement vacuum test tube during work; influence detection efficiency; staff's necessary the high concentration notice registration of sampling is simultaneously put down in writing the mistake of obscuring to prevent.Simultaneously because of the blood sample of vacuum test tube be a collection of on pallet mixing simultaneously, another carries out sampled measurements successively blood sample behind mixing, and this just exists waits in line the cycle, and in these treat the time, the blood sample of mixing can precipitate aggegation again, and it is accurate that influence is measured.And the pallet of pitch angle 45 degree sways and carries out mixing, vacuum test tube rotates the axial angle variation maximum that forms with pallet and also has only 90 degree, vacuum test tube also can only be in this scope mixing, still can not reach the mixing state of the more wide-angle variations that surpasses 90 degree, as improving the mixing effect of blood sample, just must prolong mixing time, cause the time lengthening of measuring blood viscosity, influence detection efficiency.And this blood viscosity measurement mechanism when measuring blood plasma, needs earlier blood plasma to be extracted separately to place equally, just can carry out plasma viscosity and measure.
Summary of the invention
The objective of the invention is deficiency at the prior art existence, a kind of closed automatic detection device of blood rheology measurement is provided, it can make blood rheology measurement realize the automatic transmission of blood sample under covered state, blood sample put upside down evenly mixing device automatically, the automatic ration sampling, automatically measure blood sample, automatically clean measurement mechanism, automatically identification, record, realize the automatic down blood viscosity of measuring of full closeding state, can avoid cross pollution, can alleviate staff's labour intensity again, improve measurement effect, can also shorten Measuring Time.
The object of the present invention is achieved like this: comprise sampling and measuring system, evenly mixing device, air pump, described sampling and measuring system, evenly mixing device, air pump are installed on the frame;
Described sampling and measuring system comprises sampling/surveyingpin assembly, the inserting needle drive unit, the quantitative sampling controller, upper sphere, heating component, cleaning device, station conversion driving device, described sampling/surveyingpin assembly, upper sphere, heating component is installed on the inserting needle drive unit, sampling/surveyingpin assembly is communicated with upper sphere, heating component contacts with upper sphere, described inserting needle drive unit is installed on the station conversion driving device, cleaning device is installed on the station conversion driving device, station conversion driving device is connected with bracing frame on being fixed on frame, the quantitative sampling controller is connected with the contact conductor of sampling/surveyingpin assembly, sampling/surveyingpin assembly, upper sphere connects air pump by gas piping, gas piping is provided with pressure transducer, and upper sphere connects the cleaning fluid water-supply-pipe by solenoid valve;
Described evenly mixing device is an evenly mixing device of putting upside down vertical rotation, comprise flexible clamping device, flexible clamping device rotation drive motor, move up and down device, horizontally moving device, described flexible clamping device is axially horizontal to be connected with the axle of flexible clamping device rotation drive motor, flexible clamping device rotation drive motor is installed in and moves up and down on the device, move up and down device and be installed on the horizontally moving device, horizontally moving device is installed on the supporting base fixedly connected on the frame;
The blood sample conveyer also is installed on the described frame, described blood sample conveyer comprises the test tube rack supporting plate, barcode scanner, the test tube rack mobile device, test tube rack monitoring position device, described test tube rack supporting plate is fixed on the frame, barcode scanner, the test tube rack mobile device, test tube rack monitoring position device is installed on the test tube rack supporting plate, barcode scanner is installed in in-plane on the test tube rack supporting plate, plane on the test tube rack supporting plate is divided into the dark zone, measure the station district, the recovery area, described dark zone, measure the station district, the recovery area is respectively equipped with test tube rack monitoring position device and is respectively equipped with the test tube rack mobile device;
Described air pump, inserting needle drive unit, station conversion driving device, move up and down the drive motor of device, horizontally moving device, test tube rack mobile device, with flexible clamping device rotation drive motor, and quantitative sampling controller, pressure transducer, barcode scanner, test tube rack monitoring position device, solenoid valve all are electrically connected with single-chip microcomputer.
Described station conversion driving device comprises bracing frame, sliding support, first screw rod, first drive motor, bracing frame is fixedly connected on the frame, the two ends up and down of first screw rod are rotating to be cooperated with bracing frame, uprightly be arranged in the bracing frame, first drive motor is installed on the bracing frame, machine shaft connects first screw rod, the sliding support threaded engagement on first screw rod and with bracing frame on the guide piece that is provided be slidingly matched.
Described inserting needle drive unit is made up of cantilever, second screw rod, second drive motor of supporting sampling/surveyingpin assembly, the rotating sliding support with station conversion driving device in the two ends up and down of second screw rod cooperates, uprightly be arranged in the sliding support, second drive motor is installed on the sliding support, machine shaft connects second screw rod, the cantilever threaded engagement of supporting sampling/surveyingpin assembly on second screw rod and with sliding support on the guide piece that is provided be slidingly matched.
Described sampling/surveyingpin assembly comprises that the aperture is the metal inner pipe of taking a sample/measuring of being used to of 0.5mm～0.8mm, outer metal outer pipe and the holder of pipe in being enclosed within, outer tube is shorter than interior pipe, the pipe lower end has tapered tube head in described, this tapered tube head is given prominence to the lower end at outer tube, the cone bottom diameter of tapered tube head is identical with outer external diameter of pipe, be provided with impermeability ventilation interlayer in described between pipe and the outer tube, the two ends of this impermeability ventilation interlayer are respectively with in cutting off, the insulation sleeve sealing of outer tube contact, the interior pipe on the pipeline section corresponding with outer tube is coated with insulation course, be respectively equipped with on the tube wall of described outer tube, following air hole communicates with impermeability ventilation interlayer, in, difference welding electrode lead-in wire forms two independently electrodes on the outer tube, contact conductor is connected with the quantitative sampling controller, in, holder is fixed in the upper end of outer tube, interior pipe runs through holder and is communicated with upper sphere, and described holder is fixed on the inserting needle drive unit.
The described device that moves up and down comprises upright support, tape handler, the 3rd drive motor, described upright support is fixed on the horizontally moving device, tape handler, the 3rd drive motor are installed on the upright support, the driving wheel of tape handler is connected fixedly connected flexible clamping device rotation drive motor on the driving-belt with the axle of the 3rd drive motor.
Described horizontally moving device comprises directive slide track, slide plate, bolt and nut mechanism, the moving motor of 4 wheel driven, directive slide track is horizontal to be fixed on the supporting base, slide plate and directive slide track are slidingly matched, the nut of bolt and nut mechanism is fixed on the slide plate, screw rod is connected with the moving motor of 4 wheel driven, the moving motor of 4 wheel driven is installed on the supporting base, installs on the slide plate and moves up and down device.
Described test tube rack mobile device is respectively dark zone carry mobile device, measurement station district's stepping mobile device, recovery area disengaging station mobile device, three mobile devices are respectively the gear train that comprises drive motor, and described gear train is provided with and drives the shifting block that test tube rack moves.
Described test tube rack monitoring position device comprises dark zone monitoring sensor on the throne, dark zone end point determination sensor, measures station monitoring sensor, measurement zone endpoint monitoring sensor, recovery area endpoint monitoring sensor, described dark zone monitoring sensor on the throne, measurement station monitoring sensor adopt photoelectric sensor, and described dark zone end point determination sensor, measurement zone endpoint monitoring sensor, recovery area endpoint monitoring sensor adopt touch sensor.
Described cleaning device has a cylindrical shell, the tube chamber up/down perforation of cylindrical shell, the cylindrical shell upper end is provided with the loam cake of band central through hole, the cylindrical shell lower end is provided with the guiding plug of band central through hole, the upper end of guiding plug central through hole is a bellmouth, the water draining beak that radially is provided with of guiding plug is communicated with central through hole, and the lower end of guiding plug is provided with rubber gasket, and rubber gasket is fixed on guiding plug lower end with ring cover
Described drive motor all adopts the stepper motor of two-way rotation.
Adopt such scheme, make the closed automatic detection device of blood rheology measurement of the present invention have following function and advantage:
1. adopt the sampling and measuring system that forms by sampling/surveyingpin assembly, inserting needle drive unit, quantitative sampling controller, cleaning device, station conversion driving device etc., under the driving of station conversion driving device, inserting needle drive unit, sampling/the surveyingpin of sampling/surveyingpin assembly can directly insert in the vacuum test tube of dress blood sample, take a sample and measure, not needing to realize the purpose of uncapping and detecting, can avoid cross pollution.Especially difference welding electrode lead-in wire forms two independently electrodes on the inner and outer pipe of sampling/surveyingpin, contact conductor is connected with the quantitative sampling controller, make sampling/surveyingpin form liquid surface probing needle, when measuring the blood plasma blood viscosity, control by the quantitative sampling controller, inserting needle is at the plasma layer quantitative sampling, solving blood plasma need be from the problem of lid separation, avoid cross pollution, solved the inaccurate problem of control sampling manually simultaneously, improve the accuracy of measuring, realized the repeatability of measuring.And sampling and measure and all to be undertaken by sampling/surveyingpin assembly, having shortened the path of sampling and measurement, detection efficiency is significantly improved, and cleans also more thorough.
2. adopt the evenly mixing device of putting upside down vertical rotation that the blood sample in the vacuum test tube is carried out mixing, drive flexible clamping device by horizontally moving device and clamp the vacuum test tube that is inserted on the test tube rack, make vacuum test tube break away from test tube rack by moving up and down device, flexible clamping device is clamped vacuum test tube and do the vertical rotation of putting upside down back and forth under the driving of flexible clamping device rotation drive motor, do the slow rotation repeatedly of positive and negative two directions during upside down turn, its rotational angle can reach 180 °, or above 180 °, make blood sample soft mixing in the vacuum test tube of putting upside down back and forth, blending manner with the best, in the extremely short time, realize the mixing of blood sample, improve detection efficiency.
3. the blood sample conveyer is installed on frame, by test tube rack mobile device, test tube rack monitoring position device the test tube rack that is loaded with vacuum test tube that is placed on dark zone on the test tube rack supporting plate is sent to automatically and measures the station district, and the vacuum test tube on the test tube rack measured successively, measure the back test tube rack and delivered to the recovery area automatically.Because the blood sample conveyer is provided with barcode scanner, make test tube rack the time through measurement station district, detected vacuum test tube carries out bar code scan identification successively, causes the blood sample and the measurement data contraposition of measurement, mistake can not occur obscuring.
The closed automatic detection device of blood rheology measurement of the present invention, the computing machine that connects by serial ports sends action command and accepts data, the fulfillment database operating function.
The invention will be further described below in conjunction with drawings and Examples.
Description of drawings
Fig. 1 is a structural representation of the present invention;
Fig. 2 is the structural drawing of facing of the present invention;
Fig. 3 is plan structure figure of the present invention;
Fig. 4 is the structural representation of sampling and measuring system of the present invention and evenly mixing device;
Fig. 5 is sampling of the present invention/surveyingpin assembly synoptic diagram;
Fig. 6 is the synoptic diagram of the present invention's sampling;
The synoptic diagram that Fig. 7 cleans for the present invention;
Fig. 8 is the synoptic diagram of the capillary viscosimeter of traditional prior art.
In the accompanying drawing, 1 is frame, and 2 is the blood sample conveyer, 3 is the sampling and measuring system, and 4 is evenly mixing device, 5a, 5b, 5c is the test tube rack mobile device, 6a, 6b, 6c, 6d, 6f is a test tube rack monitoring position device, and 7 is barcode scanner, and 8 is the test tube rack supporting plate, 8a is the dark zone, and 8b is for measuring the station district, and 8c is the recovery area, 9 is test tube rack, and 10 is vacuum test tube, and 11 is supporting base, 12 is flexible clamping device, and 13 is horizontally moving device, and 14 is flexible clamping device rotation drive motor, 15 for moving up and down device, and 16 is cleaning device, and 17 are sampling/surveyingpin assembly, 18 is the quantitative sampling controller, and 19 is air pump, and 20 is heating component, 20a is an infrared heater, 20b is a heating rod, and 21 is upper sphere, and 22 is the inserting needle drive unit, 23 is station conversion driving device, 24 is bracing frame, and 25 is pressure transducer, and 26 is gas piping, 27 is temperature sensor, 28 is sliding support, and 29 is first screw rod, and 30 is first drive motor, 31 is cantilever, 32 is second screw rod, and 33 is second drive motor, and 34 is interior pipe, 35 is outer tube, 36 is holder, and 37 is tapered tube head, and 38 are impermeability ventilation interlayer, 39 is insulation sleeve, 40 is insulation course, 41a, 41b is an air hole, and 42 is support, 43 is tape handler, 44 is the 3rd drive motor, and 45 is directive slide track, and 46 is slide plate, 47 is bolt and nut mechanism, 48 is the moving motor of 4 wheel driven, and 49 is cylindrical shell, and 50 is loam cake, 51 are the guiding plug, 52 is rubber gasket, and 53 is water draining beak, and 54 is ring cover.
Embodiment
Referring to Fig. 1, the closed automatic detection device of the blood rheology measurement of present embodiment, comprise sampling and measuring system 3, evenly mixing device 4, blood sample conveyer 2, air pump 19 etc., described sampling and measuring system 3, evenly mixing device 4, blood sample conveyer 2, air pump 19 are installed in frame 1 respectively, frame 1 adopts inverted T type frame, the horizonal base plate of frame bottom is provided with the upright central dividing plate that base plate is divided into forward and backward district, has bigger rectangular opening on the central dividing plate front and back district is communicated.
Referring to Fig. 1 to Fig. 7, described sampling and measuring system 3 comprises sampling/surveyingpin assembly 17, inserting needle drive unit 22, quantitative sampling controller 18, upper sphere 21, heating component 20, cleaning device 16, station conversion driving device 23, described sampling/surveyingpin assembly 17, upper sphere 21, heating component 20 are installed on the inserting needle drive unit 22, sampling/surveyingpin assembly 17 is communicated with upper sphere 21, and heating component 20 contacts with upper sphere 21.Described heating component 20 comprises infrared heater 20a, electrically heated rod 20b and temperature sensor 27.Described inserting needle drive unit 22 is installed on the station conversion driving device 23, cleaning device 16 usefulness screws are fixed on the station conversion driving device 23, station conversion driving device 23 is connected with bracing frame 24 on being fixed on frame 1, described station conversion driving device 23 comprises sliding support 28, first screw rod 29, first drive motor 30, the two ends up and down of first screw rod 29 are rotating to be cooperated with bracing frame 24, uprightly be arranged in the bracing frame 24, first drive motor 30 is installed on the bracing frame 24, machine shaft connects first screw rod 29 by gear drive, sliding support 28 threaded engagement on first screw rod 29 and with bracing frame on the guide piece that is provided be slidingly matched, described guide piece can adopt the guide rail that is provided with on the bracing frame 24, also can adopt the guide pole that is arranged on the bracing frame 24.Described inserting needle drive unit 22 is by the cantilever 31 of supporting sampling/surveyingpin assembly 19, second screw rod 32, second drive motor 33 is formed, the rotating sliding support 28 with station conversion driving device 23 in the two ends up and down of second screw rod 32 cooperates, uprightly be arranged in the sliding support, second drive motor 33 is installed on the sliding support, machine shaft connects second screw rod 32, cantilever 31 threaded engagement of supporting sampling/surveyingpin assembly 19 on second screw rod 32 and with sliding support 28 on the guide piece of setting be slidingly matched, described guide piece is the guide pole that is arranged on the sliding support 28, also can adopt the guide rail that is arranged on the sliding support 28.Described sampling/surveyingpin assembly 17 comprises that the aperture is the metal inner pipe 34 of taking a sample/measuring of being used to of 0.5mm～0.8mm, outer metal outer pipe 35 and the supporting base 36 of pipe in being enclosed within, outer tube 35 is than interior pipe 34 weak points, pipe 34 lower ends have tapered tube head 37 in described, this tapered tube head 37 is given prominence to the lower end at outer tube 35, the cone bottom diameter of tapered tube head is identical with outer external diameter of pipe, be provided with impermeability ventilation interlayer 38 in described between pipe and the outer tube, the two ends of this impermeability ventilation interlayer 38 are respectively with in cutting off, insulation sleeve 39 sealings of outer tube contact, the interior pipe on the pipeline section corresponding with outer tube is coated with insulation course 40, be respectively equipped with on the tube wall of described outer tube, following air hole 41a, 41b communicates with impermeability ventilation interlayer 38, in, difference welding electrode lead-in wire 42 forms two independently electrodes on the outer tube, contact conductor is connected with quantitative sampling controller 18, in, holder 36 is fixed in the upper end of outer tube, interior pipe 34 runs through holder and is communicated with upper sphere 21, and described holder 36 is fixed on the cantilever 31 of inserting needle drive unit.The air admission hole of sampling/surveyingpin assembly 17, upper sphere 21 connects air pump 19 by gas piping, and gas piping 26 is provided with pressure transducer 25, and the inlet opening of upper sphere 21 connects cleaning fluid water-supply-pipe (not shown) by solenoid valve.Described cleaning device 16 has a cylindrical shell 49, the tube chamber up/down perforation of cylindrical shell 49, cylindrical shell 49 upper ends are provided with the loam cake 50 of band central through hole, loam cake 50 is threaded with cylindrical shell 49, cylindrical shell 49 lower ends are provided with the guiding plug 51 of band central through hole, guiding plug 51 is threaded with cylindrical shell 49, the central through hole upper end of guiding plug 51 is a bellmouth, the water draining beak 53 that radially is provided with of guiding plug 51 is communicated with central through hole, the lower end of guiding plug 51 is provided with rubber gasket 52, rubber gasket 52 usefulness ring covers 54 are fixed on guiding plug 51 lower ends, and ring cover 54 is threaded with guiding plug 51.Described cleaning device 16 is screwed the lower side location at the sliding support 28 of station conversion driving device, and the central through hole of cleaning device 16 is corresponding with the needle tubing of sampling/surveyingpin assembly 17, is same axial line.
Referring to Fig. 1, Fig. 3, described evenly mixing device 4 is for putting upside down the evenly mixing device of vertical rotation, comprise flexible clamping device 12, flexible clamping device rotation drive motor 14, move up and down device 15, horizontally moving device 13, described flexible clamping device 12 is axially horizontal to be connected with the axle of flexible clamping device rotation drive motor 14, flexible clamping device rotation drive motor 14 is installed in and moves up and down on the device 15, move up and down device 15 and be installed on the horizontally moving device 13, horizontally moving device 13 is installed on the supporting base fixedly connected on the frame 1 11.The described device 15 that moves up and down comprises upright support 42, tape handler 43, the 3rd drive motor 44, described upright support 42 is fixed on the horizontally moving device 13, tape handler 43, the 3rd drive motor 44 is installed on the upright support 42, the driving wheel of tape handler 43 is connected with the axle of the 3rd drive motor, fixedly connected flexible clamping device rotation drive motor 14 on the driving-belt, drive tape handler 43 motions by the 3rd drive motor, make flexible clamping device rotation drive motor 14 rise or descend with driving-belt, driving flexible clamping device 12 rises or descends, flexible clamping device 12 climbs away test tube rack 9 after clamping vacuum test tube 10, under the drive of flexible clamping device rotation drive motor 14, put upside down rotation then, the mixing blood sample, dynamic elasticity clamping device 12 descends then, and vacuum test tube 10 is inserted test tube rack 9 playback.Described horizontally moving device 13 comprises directive slide track 45, slide plate 46, bolt and nut mechanism 47,4 wheel driven moves motor 48, directive slide track 45 horizontal being fixed on the supporting base 11, slide plate 46 is slidingly matched with directive slide track 45, the nut of bolt and nut mechanism 47 is fixed on the slide plate 46, screw rod is connected with the axle of the moving motor 48 of 4 wheel driven, the moving motor 48 usefulness bolt of 4 wheel driven are installed on the supporting base 11, install on the slide plate 46 and move up and down device 15, driving slide plate 46 along continuous straight runs by bolt and nut mechanism 47 under the driving of the moving motor 48 of 4 wheel driven advances, make flexible clamping device 12 clamp vacuum test tube 10 on the test tube rack 9, perhaps along continuous straight runs retreats, and the vacuum test tube 10 on flexible clamping device 12 and the test tube rack 9 is broken away from.
Referring to Fig. 1 to Fig. 3, on the described frame 1 blood sample conveyer 2 is installed also, described blood sample conveyer 2 comprises test tube rack supporting plate 8, barcode scanner 7, test tube rack mobile device 5a, 5b, 5c, test tube rack monitoring position device 6a, 6b, 6c, 6d, 6f, described test tube rack supporting plate 8 is fixed on the frame 1, barcode scanner 7, the test tube rack mobile device, test tube rack monitoring position device is installed on the test tube rack supporting plate 8, barcode scanner 7 is installed in in-plane on the test tube rack supporting plate 8, plane on the test tube rack supporting plate 8 is divided into dark zone 8a, measure station district 8b, recovery area 8c, described dark zone 8a, measure station district 8b, recovery area 8c is respectively equipped with test tube rack monitoring position device and is respectively equipped with the test tube rack mobile device.Described test tube rack mobile device is respectively dark zone mobile device 5a, measures station district mobile device 5b, recovery area mobile device 5c, three mobile devices are respectively the gear train that comprises drive motor, these gear trains all are separately positioned on the below of test tube rack supporting plate 8, and gear train is provided with and drives the shifting block that test tube rack 9 moves.Described gear train adopts tape handler for well, fixing shifting block on its driving-belt, shifting block can stretch out the test tube rack 9 that promotes to be placed on plane on the test tube rack supporting plate 8 from the strip hole that test tube rack supporting plate 8 is provided with and move a segment distance, and test tube rack 9 is delivered to the desired position.Described test tube rack monitoring position device comprises dark zone monitoring sensor 6a on the throne, dark zone end point determination sensor 6b, measure station monitoring sensor 6c, measurement zone endpoint monitoring sensor 6d, recovery area endpoint monitoring sensor 6f, described dark zone monitoring sensor 6a on the throne, measure station monitoring sensor 6c and adopt photoelectric sensor, described dark zone end point determination sensor 6d, measurement zone endpoint monitoring sensor 6d, recovery area endpoint monitoring sensor 6f adopts touch sensor, detection control test tube rack 9 dark zone 8a on test tube rack supporting plate successively 8 by these sensors, measure station district 8b, recovery area 8c moves, the test tube rack 9 of vacuum test tube will have been loaded, just drive down from being placed on dark zone 8a by the test tube rack mobile device, automatically enter measurement station district and measure one by one, enter the recovery area then automatically.
The described air pump 19 of apparatus of the present invention, inserting needle drive unit 22, station conversion driving device 23, move up and down the drive motor of device 15, horizontally moving device 13, the drive motor of test tube rack mobile device 14, with flexible clamping device rotation drive motor 14, and quantitative sampling controller 18, pressure transducer 25, temperature sensor 27, barcode scanner 7, test tube rack monitoring position device, solenoid valve all are electrically connected with single-chip microcomputer, single-chip microcomputer is connected with serial ports of computers, send action command and accept data by computing machine, the fulfillment database operating function.
When the closed automatic detection device of blood rheology measurement of the present invention is worked, the single test tube rack that a collection of vacuum test tube is housed is placed on the dark zone, automatically deliver to measurement station zone position by the test tube rack mobile device, at first by barcode scanner first vacuum test tube being finished sample confirms, the flexible clamping device of evenly mixing device clamps this vacuum test tube then, vacuum test tube is climbed away test tube rack, put upside down vertical rotation mixing blood sample, do the slow rotation repeatedly of positive and negative two directions during upside down turn, its rotational angle can reach 180 °, or surpass 180 °, make blood sample soft mixing in the vacuum test tube of putting upside down back and forth.Behind the mixing vacuum test tube is put back to test tube rack, test tube rack moves a vacuum test tube position, enters the measuring position.After this vacuum test tube enters the measuring position, station conversion driving device moves downward, cleaning device compresses vacuum test tube, the inserting needle drive unit moves downward subsequently, the needle tubing of sampling/surveyingpin assembly passes rubber gasket from the central through hole of cleaning device, the fluid sealant lid that pierces through on the vacuum test tube inserts in the blood sample, its degree of depth that enters the blood sample liquid level is controlled by the quantitative sampling controller, air pump starts, in vacuum test tube, grant air pressure by the ventilation of the impermeability on the needle tubing of sampling/surveyingpin assembly interlayer, force the interior pipe of blood sample from needle tubing by entering the upper sphere, air pump quits work when pressure transducer detects pressure above threshold value, pressurization finishes, finish sampling, the upper vent hole of the interlayer of impermeability ventilation is subsequently connected the valve opening of atmosphere, impermeability ventilation interlayer is communicated with atmosphere, air pressure pressure release in the vacuum test tube, blood sample sample in the upper sphere is under the double action of draught head and gravity, metal inner pipe through being used to take a sample/measure flows back to vacuum test tube, force value in the pressure transducer record reflux course, by the pressure measure of the change of blood sample sample from the metal inner pipe reflux course, computing machine obtains pressure curve and calculates blood viscosity value, and the storage data.After measurement was finished, the inserting needle drive unit drove the sampling/surveyingpin assembly slow astern set a distance that makes progress, and makes the lower port of sampling/surveyingpin be positioned at the cleaning device chamber, and cleaning fluid is flowed through from the upper sphere injection behind sampling/surveyingpin, from the water draining beak discharge of cleaning device.After measurement, cleaning are finished, station conversion driving device moves upward and drives sampling/surveyingpin assembly and cleaning device rising, break away from vacuum test tube, test tube rack moves under the drive of test tube rack mobile device and makes next vacuum test tube enter the measuring position, carry out measurement to the blood sample of next vacuum test tube, the process of measuring, cleaning with preceding identical.What deserves to be mentioned is, when previous vacuum test tube is measured, evenly mixing device carries out mixing to next vacuum test tube simultaneously, after treating that previous vacuum test tube measurement finishes, next vacuum test tube also mixing finishes, and in time measures, can avoid to be measured of long duration and blood sample produces the phenomenon of precipitation aggegation behind the mixing, carry out so successively, can save a large amount of time, improve efficiency of measurement.Behind the vacuum test tube, test tube rack is automatically moved to the recovery area under the test tube rack mobile device drives on the intact test tube rack to be measured, and next test tube rack enters successively measures the station district, carries out the test of a collection of blood sample.
The closed automatic detection device of blood rheology measurement of the present invention, after the whole blood viscosity measurement is finished, the vacuum test tube of measuring whole blood viscosity can be carried out centrifugal after, and then the machine of going up carries out the plasma viscosity measurement according to above-mentioned measuring process, owing to there is barcode scanner to scan, quantitative sampling controller control quantitative sampling is arranged, have the repeatability that can accurately repeat, its measurement result is checked the number can entanglement yet.
Claims (10)
1. the closed automatic detection device of a blood rheology measurement comprises sampling and measuring system (3), evenly mixing device (4), air pump (19), it is characterized in that: described sampling and measuring system (3), evenly mixing device (4), air pump (19) are installed on the frame (1);
Described sampling and measuring system (3) comprises sampling/surveyingpin assembly (17), inserting needle drive unit (22), quantitative sampling controller (18), upper sphere (21), heating component (20), cleaning device (16), station conversion driving device (23), described sampling/surveyingpin assembly (17), upper sphere (21), heating component (20) is installed on the inserting needle drive unit (22), sampling/surveyingpin assembly is communicated with upper sphere, heating component contacts with upper sphere, described inserting needle drive unit (22) is installed on the station conversion driving device (23), cleaning device (18) is installed on the station conversion driving device (23), station conversion driving device (23) is connected with bracing frame (24) on being fixed on frame (1), quantitative sampling controller (18) is connected with the contact conductor of sampling/surveyingpin assembly (17), sampling/surveyingpin assembly, upper sphere connects air pump (19) by gas piping (26), gas piping is provided with pressure transducer (25), and upper sphere connects the cleaning fluid water-supply-pipe by solenoid valve;
Described evenly mixing device (4) is for putting upside down the evenly mixing device of vertical rotation, comprise flexible clamping device (12), flexible clamping device rotation drive motor (14), move up and down device (15), horizontally moving device (13), described flexible clamping device (12) is axially horizontal to be connected with the axle of flexible clamping device rotation drive motor (14), flexible clamping device rotation drive motor (14) is installed in and moves up and down on the device (15), move up and down device (15) and be installed on the horizontally moving device (13), horizontally moving device (13) is installed on the supporting base fixedly connected on the frame (11);
Blood sample conveyer (2) also is installed on the described frame (1), described blood sample conveyer (2) comprises test tube rack supporting plate (8), barcode scanner (7), the test tube rack mobile device, test tube rack monitoring position device, described test tube rack supporting plate (8) is fixed on the frame, barcode scanner (7), the test tube rack mobile device, test tube rack monitoring position device is installed on the test tube rack supporting plate (8), barcode scanner (7) is installed in test tube rack supporting plate (8) and goes up in-plane, test tube rack supporting plate (8) is gone up the plane be divided into dark zone (8a), measure station district (8b), recovery area (8c), described dark zone, measure the station district, the recovery area is respectively equipped with test tube rack monitoring position device and is respectively equipped with the test tube rack mobile device;
Described air pump, inserting needle drive unit (22), station conversion driving device (23), move up and down the drive motor of device (15), horizontally moving device (13), test tube rack mobile device, with flexible clamping device rotation drive motor (14), and quantitative sampling controller (18), pressure transducer (25), barcode scanner (7), test tube rack monitoring position device, solenoid valve all are electrically connected with single-chip microcomputer.
2. the closed automatic detection device of blood rheology measurement according to claim 1, it is characterized in that: described station conversion driving device (23) comprises bracing frame (24), sliding support (28), first screw rod (29), first drive motor (30), bracing frame (24) is fixedly connected on the frame (1), the two ends up and down of first screw rod (29) are rotating to be cooperated with bracing frame, uprightly be arranged in the bracing frame (24), first drive motor (30) is installed on the bracing frame (24), machine shaft connects first screw rod (29), and sliding support (28) threaded engagement goes up and goes up the guide piece that is provided with bracing frame (24) at first screw rod (29) and is slidingly matched.
3. the closed automatic detection device of blood rheology measurement according to claim 1, it is characterized in that: described inserting needle drive unit (22) is by the cantilever (31) of supporting sampling/surveyingpin assembly, second screw rod (32), second drive motor (33) is formed, the two ends up and down of second screw rod (32) are rotating to be cooperated with the sliding support (28) of station conversion driving device, uprightly be arranged in the sliding support (28), second drive motor (33) is installed on the sliding support (28), machine shaft connects second screw rod (32), and cantilever (31) threaded engagement of supporting sampling/surveyingpin assembly goes up and goes up the guide piece that is provided with sliding support (28) at second screw rod (32) and is slidingly matched.
4. the closed automatic detection device of blood rheology measurement according to claim 1, it is characterized in that: described sampling/surveyingpin assembly (17) comprises that the aperture is the metal inner pipe (34) of taking a sample/measuring of being used to of 0.5mm～0.8mm, outer metal outer pipe (35) and the holder (36) of pipe in being enclosed within, outer tube is shorter than interior pipe, pipe (34) lower end has tapered tube head (37) in described, this tapered tube head (37) is given prominence to the lower end in outer tube (35), the cone bottom diameter of tapered tube head is identical with outer external diameter of pipe, be provided with impermeability ventilation interlayer (38) in described between pipe (34) and the outer tube (35), the two ends of this impermeability ventilation interlayer (38) are respectively with in cutting off, insulation sleeve (39) sealing of outer tube contact, the interior pipe on (34) pipeline section corresponding with outer tube (35) is coated with insulation course (40), be respectively equipped with on the tube wall of described outer tube (35), following air hole communicates with impermeability ventilation interlayer (38), in, difference welding electrode lead-in wire forms two independently electrodes on the outer tube, contact conductor is connected with quantitative sampling controller (18), in, holder (36) is fixed in the upper end of outer tube, interior pipe (34) runs through holder (36) and is communicated with upper sphere (21), and described holder (36) is fixed on the inserting needle drive unit (22).
5. the closed automatic detection device of blood rheology measurement according to claim 1, it is characterized in that: the described device (15) that moves up and down comprises upright support (42), tape handler (43), the 3rd drive motor (44), described upright support (42) is fixed on the horizontally moving device (13), tape handler (43), the 3rd drive motor (44) are installed on the upright support (42), the driving wheel of tape handler (43) is connected fixedly connected flexible clamping device rotation drive motor (14) on the driving-belt with the axle of the 3rd drive motor (44).
6. the closed automatic detection device of blood rheology measurement according to claim 1, it is characterized in that: described horizontally moving device (13) comprises directive slide track (45), slide plate (46), bolt and nut mechanism (47), 4 wheel driven moves motor (48), directive slide track (45) is horizontal to be fixed on the supporting base (11), slide plate (46) is slidingly matched with directive slide track (45), the nut of bolt and nut mechanism (47) is fixed on the slide plate (46), screw rod is connected with 4 wheel driven moving motor (48), 4 wheel driven moves motor (48) and is installed on the supporting base (11), and slide plate (46) is gone up to install and moved up and down device (15).
7. the closed automatic detection device of blood rheology measurement according to claim 1, it is characterized in that: described test tube rack mobile device is respectively dark zone mobile device (5a), measures station district's mobile device (5b), recovery area mobile device (5c), three mobile devices are respectively the gear train that includes drive motor, and described gear train is provided with and drives the shifting block that test tube rack moves.
8. the closed automatic detection device of blood rheology measurement according to claim 1, it is characterized in that: described test tube rack monitoring position device comprises dark zone monitoring sensor on the throne, dark zone end point determination sensor, measures station monitoring sensor, measurement zone endpoint monitoring sensor, recovery area endpoint monitoring sensor, described dark zone monitoring sensor on the throne, measurement station monitoring sensor adopt photoelectric sensor, and described dark zone end point determination sensor, measurement zone endpoint monitoring sensor, recovery area endpoint monitoring sensor adopt touch sensor.
9. the closed automatic detection device of blood rheology measurement according to claim 1, it is characterized in that: described cleaning device (16) has a cylindrical shell (49), the tube chamber up/down perforation of cylindrical shell (49), cylindrical shell (49) upper end is provided with the loam cake (50) of band central through hole, cylindrical shell (49) lower end is provided with the guiding plug (51) of band central through hole, the upper end of guiding plug (51) central through hole is a bellmouth, the water draining beak (53) that radially is provided with of guiding plug (51) is communicated with central through hole, the lower end of guiding plug (51) is provided with rubber gasket (52), and rubber gasket (52) is fixed on guiding plug (51) lower end with ring cover (54).
10. according to the closed automatic detection device of claim 1,2,3 or 5,6,7 arbitrary described blood rheology measurements, it is characterized in that: described drive motor all adopts the stepper motor of two-way rotation.
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| CN2009103043296A CN101603968B (en) | 2009-07-14 | 2009-07-14 | Closed automatic detection device for blood rheology measurement |
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| CN2009103043296A CN101603968B (en) | 2009-07-14 | 2009-07-14 | Closed automatic detection device for blood rheology measurement |
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| CN2009103043296A Expired - Fee Related CN101603968B (en) | 2009-07-14 | 2009-07-14 | Closed automatic detection device for blood rheology measurement |
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