CN1808097A - Method for quickly determining blood viscosity - Google Patents
Method for quickly determining blood viscosity Download PDFInfo
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- CN1808097A CN1808097A CN 200510057357 CN200510057357A CN1808097A CN 1808097 A CN1808097 A CN 1808097A CN 200510057357 CN200510057357 CN 200510057357 CN 200510057357 A CN200510057357 A CN 200510057357A CN 1808097 A CN1808097 A CN 1808097A
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Abstract
The invention relates to a method for detecting apparent viscosity of blood, which comprises steps of: employing a lean rotary main body to cooperate with vacuum blood collection tube for making the blood sample in the vacuum blood collection tube realize nondestructive mixing; under the driving of motor, the front end of measuring main body piercing into the seal rubber pad of the vacuum blood collection tube and inserting into the blood sample; adding pressure to the vacuum blood collection tube, making blood enter measuring ball via capillary tube, then making the vacuum blood collection tube communicate with air, blood in the measuring ball being discharged back to the vacuum blood collection via capillary tube; the gas pressure in the measuring ball changed correspondingly, measuring the gas pressure variation progress in the measuring ball with the pressure sensor to calculating the apparent viscosity of blood; washing the measuring ball and the capillary tube with washing liquid, then acting high temperature and high pressure air on the measuring ball and the capillary tube to make them clean and dry to ensure the accuracy of the measuring results.
Description
Under technical field: the present invention and Newtonian fluid, non-newtonian flow bulk measurement are relevant, especially relevant with the viscosity measurement of liquid, especially with to be used for blood viscosity fast detection device relevant.
Background technology: blood viscosity is the most important and the most basic rheological properties of blood clinically, the mensuration of blood viscosity parameter, to understanding the mobile of blood and the Changing Pattern under physiology and pathological conditions thereof, it is significant to diagnose, prevent and treat the unusual disease of blood viscosity.The kind of measuring the blood viscosity instrument is a lot, and commonly used at present have two kinds of forms: capillary viscosimeter and rotary viscosimeter.Capillary viscosimeter is simple to operate with it, it is quick to measure, and advantage such as cheap and generally being adopted by domestic hospital.The CV-100 (air-flotation type) of the very many as German HAAKE company of the existing instrument relevant with measuring blood viscosity, the LOW SHEAR30 (suspension-wire type) of Switzerland CONTRAVES company, domestic LBY-N6B Puli is living, diligent generation Supreme Being etc. among the R90.All these measuring instruments can both be measured non-Newtonian fluid, and they respectively have relative merits: rotary have higher measuring accuracy under low cut rate, but turbulent flow occurs easily and influence measuring accuracy under high shear rate, and test and cleaning process relative complex.And the more rotary flow graph of capillary rheometer measuring accuracy is low, but it can draw continuous viscosity number under different shear rates and use the very convenient thereby use in a large number clinically of operation, the flow process of while blood in human vas, identical with the flow process in kapillary, therefore, the result that draws of kapillary mensuration should be able to more effectively illustrate blood flow process in human body.If can solve the poor slightly defective of capillary type measuring system measuring accuracy, then will help the blood viscosity measuring system in clinical popularizing.
Summary of the invention:
The present invention is by rotating main body, vacuum test tube, measurement ball, micro-pressure sensor, kapillary, constant temperature system, and pump, control system etc. are partly formed.Tilted-putted rotation main body and vacuum test tube synergy makes the blood sample in the vacuum test tube realize harmless mixing during test, the measurement body front end is thrust the vacuum test tube sealing rubber pad and is inserted in the blood sample under the driving of motor, by vacuum test tube is pressurizeed, blood is entered by kapillary to be measured in the ball, allow vacuum test tube communicate then with atmosphere, the blood of measuring in the ball under the effect of pressure reduction will flow back in the vacuum test tube by kapillary, gaseous tension also changes thereupon in the measurement ball, detect the change process of measuring air pressure in the ball with pressure transducer, thereby can calculate the apparent viscosity of blood.Measurement finishes and adopts high temperature and high pressure gas to act on measurement ball and kapillary to measuring after ball and kapillary clean with cleaning fluid, guarantees to measure ball and cleaning capillaceous and drying, is convenient to follow-up test.
The present invention:
1. adopt the malleation mode that blood is pressed into and measure in the ball, avoid inhaling the negative pressure of introducing in the sample process and in blood, bubble occurs and influence measurement result;
2. realize the harmless mixing of blood, greatly reduced operator's working strength;
3. all test processs all under enclosed environment, avoid operating personnel to contact with the direct of sample, greatly reduce the danger of infection.
4. compare with existing capillary blood viscosity test system, significantly reduced pipeline and the threeway in the measuring system, avoid in pipeline and threeway, occurring residual liquid;
5. adopt dry ball and the kapillary measured of high temperature and high pressure gas, further reduced the influence of residual liquid.
The present invention's technical scheme that is adopted of dealing with problems is:
As Fig. 1 (measurement main body)
A wherein hole and connect micro-pressure sensor and two position two-way valve, two holes is arranged above glass spheres, another hole polyphone two position three-way valve and scavenging pump, there is a square connector spheroid below, high precision capillary measuring tube is equipped with in the below of connector, on the kapillary outer wall sleeve pipe is housed, between sleeve pipe top and the connector pore is arranged, there is an opening sleeve pipe below apart from the about 7Cmm of injection port place, and the air flue that this pore and opening form is used for adding gases at high pressure (sample introduction process) or logical atmosphere (sampling process).
Fig. 2,3 (sample introduction mechanisms)
This mechanism sends instruction by host computer to control circuit board in when work and drives main planker through stepper motor and move downwards, main planker front end is equipped with displacement transducer and tapered steady arm, this steady arm top is connected with Washing cup, and master's planker is out of service when tapered steady arm and pressure transducer touch the vacuum test tube top.In the above course of work, place the pressure transducer of tapered steady arm front end to detect electric signal after main planker stepper motor out of service, measuring system simultaneously start working, rotate by stepper motor gear driven ball screw, ball screw nut drive this moment is measured main element and is moved downward, and measures body front end and thrusts the vacuum test tube sealing rubber pad, halts behind its detection and location signal in measuring head front end insertion liquid.Master control borad obtain measuring after the positioning signal the external threeway of main body outer tube top gas port with and the air pump and the two position two-way valve that connect start working, gases at high pressure enter in the vacuum test tube by air flue, it is mobile to the spheroid top that this moment, the vacuum test tube internal pressure was higher than measurement glass spheres (spheroid is communicated with atmosphere by valve) liquid this moment, spheroid top valve closing after liquid is filled with kapillary and arrived the spheroid bottom, liquid continues to enter, after measuring spheroid internal pressure rising micro-pressure sensor and detecting setting value, quit work solenoid valve in the coincidence circuit of air pump is opened with atmosphere and is communicated with in the air flue loop.Meanwhile host computer procedure begins sampling calculating by control panel, micro-pressure sensor and the result is saved in the database.Data are preserved the back measuring system and are begun to move upward in measuring head arrival Washing cup (displacement transducer location), the scavenging pump of glass spheres top begins after spheroid intracontour waterflooding, water filling two position three-way valve and switches pipeline inserted in the atmosphere air is injected in the spheroid, and water enters in the Washing cup in this process by kapillary that the waterflood pump unwatering pump of wiper mechanism is worked simultaneously, water injects in the cup and simultaneously waste water discharged.Cleaning is finished laggard model machine structure and is moved upward, and tapered steady arm and vacuum test tube disengaging are caught and touched.
Fig. 4 (wiper mechanism)
The Washing cup upper and lower respectively has a pilot seal part, below pilot seal part is equipped with taper locatees this device, pilot seal part, taper steady arm centre bit are equipped with a circular hole, the cup upper left side has a water inlet lower right to have this mechanism of freeing port intake pump when work to begin to wash by water the outside draining of unwatering pump in cup.
Fig. 5 (mixing mechanism)
This mechanism has this pallet of a pallet to become miter angle with surface level, the pallet center has this bottom of pallet axle that bearing is housed, bearing be contained on the bearing seat and with base plate be connected, the base plate left surface is equipped with stepper motor, gear is housed on the step motor shaft, and pallet axle center is equipped with this gear of follower gear and is meshed with the stepper motor driving gear.Vacuum test tube is put into the pallet hole, and mixing mechanism vacuum test tube sample in the pallet hole when work is put upside down the abundant mixing of sample back and forth along with pallet rotates into an angle of 90 degrees.
Gordian technique of the present invention is:
The capillary measuring tube be installed in have in the specific sleeve pipe gapped between this sleeve pipe and kapillary, this design focal point is that kapillary and sleeve-shaped sleeve pipe in aggregates upper end has that the end distance opening part upwards also has an aperture in about 7CMM place under an aperture, the sleeve pipe, air cushion layer between kapillary and the sleeve pipe, aperture form an air flue, this air flue keeps being communicated with atmosphere when the measurement main body is thrust vacuum test tube, can inject gases at high pressure by this air flue in pipe.Sample directly enters kapillary without any subsidiary conduit in measuring process, this design makes more compact and reasonable of whole apparatus structure, and measuring accuracy and speed improve greatly.
The present invention is further described below in conjunction with drawings and Examples for description of drawings.
The measurement main structure chart of Fig. 1 device
Fig. 2 device sample introduction mechanism map
Fig. 3 device sample introduction mechanism map
Fig. 4 purging system structural drawing
Fig. 5 mixing system construction drawing
Embodiment
In Fig. 1, measure hole, a left side, spheroid 4 tops and be connected with three-way pipe in threeway and connect two-position two-way solenoid valve 1 and micro-pressure sensor 2, the upper right square hole of spheroid is connected with the pump housing 3 and connects with two-position three way magnetic valve 5, two-position three way magnetic valve 5 normal openings are communicated with atmosphere, normally closed port is put in the cleaning fluid, the spheroid below has in a connector 6 sleeve pipes 8 is equipped with kapillary 11, this compound tube has realized that by connector 6 kapillary 11 and spheroid 4 endoporus are excessively slick and sly, the 3CMM place has this hole of aperture and is connected with threeway between sleeve pipe 8 tops and the connector 6, threeway one end connects the pump housing 7 other ends and connects two-position two-way solenoid valve 9, upwards have an aperture in about 7CMM place at sleeve pipe 8 apart from injection port, this aperture and sleeve pipe 8 top apertures form an air flue.
In Fig. 2 Fig. 3
In Fig. 4
Cup 36 is equipped with pilot seal element 35 up and down, below pilot seal element 35 bottoms position by the 39 pairs of vacuum test tubes 20 of taper steady arm 39 these steady arms that are threaded, cup 36 upper left square holes are connected the bottom right square hole and are connected with unwatering pump 38 with waterflood pump 37.
In Fig. 5
Pallet 40 is installed on the pallet axle 44 and becomes 45 to spend with level, pallet axle below is equipped with bearing 48 pallet axles middle part and gear 41 these gears are housed are meshed with gear 45 on the stepper motor 42, bearing seat 47 is installed on the base plate 46, and the left side of base plate 46 is equipped with electric machine support 43 these supports and is used for supporting stepper motor 42.Stepper motor 42 rotated together by gearing mesh drive pallet axle 44 pallets 40 grades after controllor for step-by-step motor was received electric signal.
Claims (9)
1. fully automatic blood apparent viscosity detection method, it is formed by measuring main body, sampling system, purging system, mixing mechanism; It is characterized in that: the blood in the vacuum test tube enters in the measurement ball by kapillary under the pressurized air effect, allow vacuum test tube communicate then with atmosphere, blood flows back in the vacuum test tube by kapillary under the compressed-air actuated effect in measuring ball, gaseous tension also changes thereupon in the measurement ball, detect the change process of measuring air pressure in the ball with pressure transducer, thereby calculate bloodviscosity.
2. measure main body according to indication in the right 1, it is characterized in that: the measuring tube that forms after kapillary and the sleeve combination must have the outer wall upper and lower side of air cushion layer and measuring tube to have aperture between kapillary and the sleeve pipe.
3. measure main body according to indication in the right 1, it is characterized in that: measuring tube upper end aperture connects three-way pipe and is parallel with pump and the formed air flue of operation valve.
4. measure main body according to indication in the right 1, it is characterized in that: measuring tube and connector and glass spheres endoporus are excessively slick and sly, the spheroid top has two apertures and wherein connects threeway and micro-pressure sensor in parallel and operation valve in a hole, another hole of any part, spheroid top, this hole and pump or contact with any solenoid valve.
5. according to indication sampling system in the right 1, it is characterized in that: on the main planker screw mandrel is installed, the axis of guide and the gear train that can move up and down.
6. according to indication sampling system in the right 1, it is characterized in that: the screw mandrel supporting base is installed on the main planker, and the bearing upper end is equipped with square or circular Washing cup and steady arm.
7. according to indication purging system in the right 1, it is characterized in that: have aperture about square or circular Washing cup, the cup upper and lower side is equipped with the pilot seal element.
8. according to indication purging system in the right 1, it is characterized in that: be connected with intake pump or unwatering pump and valve and bottom at the square or circular Washing cup left and right sides aperture taper steady arm is housed.
9. according to indication mixing mechanism in the right 1, it is characterized in that: the pallet axle is installed with level and is become 45 degree or 90 degree, and gear or synchronous pulley are equipped with in pallet axle middle part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510057357 CN1808097A (en) | 2005-11-02 | 2005-11-02 | Method for quickly determining blood viscosity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510057357 CN1808097A (en) | 2005-11-02 | 2005-11-02 | Method for quickly determining blood viscosity |
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| Publication Number | Publication Date |
|---|---|
| CN1808097A true CN1808097A (en) | 2006-07-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200510057357 Pending CN1808097A (en) | 2005-11-02 | 2005-11-02 | Method for quickly determining blood viscosity |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101603968B (en) * | 2009-07-14 | 2011-12-21 | 重庆天海医疗设备有限公司 | Closed automatic detection device for blood rheology measurement |
-
2005
- 2005-11-02 CN CN 200510057357 patent/CN1808097A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101603968B (en) * | 2009-07-14 | 2011-12-21 | 重庆天海医疗设备有限公司 | Closed automatic detection device for blood rheology measurement |
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Open date: 20060726 |