CN112274513B - 含有吡咯喹啉醌三锂盐九水化合物的药物组合物、胶囊剂及其制备方法 - Google Patents

含有吡咯喹啉醌三锂盐九水化合物的药物组合物、胶囊剂及其制备方法 Download PDF

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Publication number
CN112274513B
CN112274513B CN202011573509.7A CN202011573509A CN112274513B CN 112274513 B CN112274513 B CN 112274513B CN 202011573509 A CN202011573509 A CN 202011573509A CN 112274513 B CN112274513 B CN 112274513B
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pyrroloquinoline quinone
capsule
pharmaceutically acceptable
salt nonahydrate
trilithium salt
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CN202011573509.7A
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Chinese (zh)
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CN112274513A (zh
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张寰
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Shanghai Rixin Pharmaceutical Technology Co.,Ltd.
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Shanghai Ri Xin Biotechnology Co ltd
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Priority to CN202011573509.7A priority Critical patent/CN112274513B/zh
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Publication of CN112274513B publication Critical patent/CN112274513B/zh
Priority to EP21913909.4A priority patent/EP4268821A4/en
Priority to JP2023539383A priority patent/JP7729639B2/ja
Priority to US18/269,783 priority patent/US20240058323A1/en
Priority to PCT/CN2021/138255 priority patent/WO2022143168A1/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN202011573509.7A 2020-12-28 2020-12-28 含有吡咯喹啉醌三锂盐九水化合物的药物组合物、胶囊剂及其制备方法 Active CN112274513B (zh)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN202011573509.7A CN112274513B (zh) 2020-12-28 2020-12-28 含有吡咯喹啉醌三锂盐九水化合物的药物组合物、胶囊剂及其制备方法
EP21913909.4A EP4268821A4 (en) 2020-12-28 2021-12-15 PHARMACEUTICAL COMPOSITION CONTAINING PYRROLOQUINOLINEQUINONETRILITHIUM SALT NONHYDRATE COMPOUND, CAPSULE AND MANUFACTURING PROCESS THEREOF
JP2023539383A JP7729639B2 (ja) 2020-12-28 2021-12-15 ピロロキノリンキノントリリチウム塩九水和物化合物を含む医薬組成物、カプセル剤およびその製造方法
US18/269,783 US20240058323A1 (en) 2020-12-28 2021-12-15 Pharmaceutical composition containing pyrroloquinoline quinone trilithium salt nonahydrate compound, capsule, and preparation method therefor
PCT/CN2021/138255 WO2022143168A1 (zh) 2020-12-28 2021-12-15 含有吡咯喹啉醌三锂盐九水化合物的药物组合物、胶囊剂及其制备方法

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CN202011573509.7A CN112274513B (zh) 2020-12-28 2020-12-28 含有吡咯喹啉醌三锂盐九水化合物的药物组合物、胶囊剂及其制备方法

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CN112274513A CN112274513A (zh) 2021-01-29
CN112274513B true CN112274513B (zh) 2021-03-26

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US (1) US20240058323A1 (https=)
EP (1) EP4268821A4 (https=)
JP (1) JP7729639B2 (https=)
CN (1) CN112274513B (https=)
WO (1) WO2022143168A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112274513B (zh) * 2020-12-28 2021-03-26 上海日馨生物科技有限公司 含有吡咯喹啉醌三锂盐九水化合物的药物组合物、胶囊剂及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103351387A (zh) * 2013-07-01 2013-10-16 上海日馨生物科技有限公司 吡咯喹啉醌锂盐晶体及其制备方法和应用
CN105189501A (zh) * 2013-04-26 2015-12-23 三菱瓦斯化学株式会社 黄色系还原型吡咯喹啉醌结晶及其制造方法、以及食品、医药品、凝胶、组合物和组合物的制造方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63215628A (ja) * 1987-03-03 1988-09-08 Sogo Yatsukou Kk グリオキサラ−ゼｉ阻害剤
US5039699A (en) * 1989-03-27 1991-08-13 Lederle (Japan), Ltd. Anti-peptic ulcer agent
WO2006025247A1 (ja) 2004-08-30 2006-03-09 Kaneka Corporation ミトコンドリア賦活剤
CN101851234A (zh) * 2009-04-03 2010-10-06 上海日馨生物科技有限公司 吡咯喹啉醌锂盐衍生物及其制备方法
JP5636671B2 (ja) * 2009-12-17 2014-12-10 三菱瓦斯化学株式会社 ピロロキノリンキノンＬｉ塩の製造方法
JP6160621B2 (ja) * 2012-08-17 2017-07-12 三菱瓦斯化学株式会社 ピロロキノリンキノンテトラアルカリ塩及びその結晶、これらの製造方法、並びに、組成物
JP6439503B2 (ja) 2014-03-13 2018-12-19 大正製薬株式会社 固形製剤
CN112274513B (zh) * 2020-12-28 2021-03-26 上海日馨生物科技有限公司 含有吡咯喹啉醌三锂盐九水化合物的药物组合物、胶囊剂及其制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105189501A (zh) * 2013-04-26 2015-12-23 三菱瓦斯化学株式会社 黄色系还原型吡咯喹啉醌结晶及其制造方法、以及食品、医药品、凝胶、组合物和组合物的制造方法
CN103351387A (zh) * 2013-07-01 2013-10-16 上海日馨生物科技有限公司 吡咯喹啉醌锂盐晶体及其制备方法和应用

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EP4268821A4 (en) 2024-12-11
WO2022143168A1 (zh) 2022-07-07
JP2024500545A (ja) 2024-01-09
US20240058323A1 (en) 2024-02-22
JP7729639B2 (ja) 2025-08-26
EP4268821A1 (en) 2023-11-01
CN112274513A (zh) 2021-01-29

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Address after: No.1, Lane 215, Amber Road, Pudong New Area, Shanghai, 201321

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Address before: No.1, Lane 215, Amber Road, Pudong New Area, Shanghai, 201321

Patentee before: Shanghai Ri Xin Biotechnology Co.,Ltd.

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