CN112220722A - Bacteriostatic no-wash hand sanitizer containing cold-extracted emblic leafflower fruit extract and preparation method thereof - Google Patents
Bacteriostatic no-wash hand sanitizer containing cold-extracted emblic leafflower fruit extract and preparation method thereof Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses an antibacterial no-clean hand sanitizer containing an emblic leafflower fruit extract and a preparation method thereof. The raw materials comprise alkyl glycoside Glucopon 600CSUP, glycerin, hydroxypropyl methylcellulose, carbomer, cold-extracted Phyllanthus emblica extract, sodium hyaluronate and the like. The preparation method comprises the following steps: dissolving alkyl glycoside Glucopon 600CSUP, glyceryl monostearate and carboxymethyl chitosan in ethanol to obtain phase A; dissolving glycerol, coconut oil, hydroxypropyl methyl cellulose, hydroxyethyl cellulose and carbomer in partial deionized water to form a phase B; dissolving cold-extracted fructus Phyllanthi extract, lauryl betaine, and sodium hyaluronate in the rest deionized water to form phase C; stirring A, B, C phase, mixing well, stirring well to transparent gel, and standing. The antibacterial no-wash hand sanitizer has a good antibacterial effect, can moisten and moisturize hand skin while washing hands, and has natural emblic leafflower fruit fragrance.
Description
Technical Field
The invention relates to a hand sanitizer, in particular to an antibacterial no-clean hand sanitizer containing a cold-extracted emblic leafflower fruit extract and a preparation method thereof, and belongs to the technical field of processing of daily chemical products.
Background
With the increase of awareness of people on health and safety, people do not limit the consumption of the hand sanitizer in daily life to toilets and relational expressions any more, and the demand for portable and portable no-clean hand sanitizers becomes greater and greater. Meanwhile, the continuous rise of the consumption level ensures that people do not pay attention to the single decontamination capability of the hand sanitizer any more, but pay more attention to the cleaning agent with multiple functions, which has the concepts of functionality, skin feeling, natural sources of added raw materials and the like, and the cleaning agent is bound to be more favored by consumers. The traditional hand sanitizer consists of a cleaning agent, an emulsifier, a chelating agent, a viscosity control agent and the like. The bacteriostatic agent is mainly dependent on synthetic raw materials, and the synthetic bacteriostatic agent can cause potential threat to the body. In the process of re-extracting and purifying the functional components of the natural plants, the heating operation can cause the volatilization and the deterioration of the heat-sensitive components in the extract, not only the fragrance of the extract is influenced, but also important functional components disappear, and the added value of the product is influenced.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: the natural plant bacteriostatic agent adopted by the traditional hand sanitizer has the problems of easy volatilization, easy deterioration and the like in the preparation process.
In order to solve the technical problem, the invention provides an antibacterial leave-on hand sanitizer containing an emblic extract, which is characterized in that raw materials comprise, by mass per thousand, alkyl glycoside Glucopon 600CSUP1-3 per thousand, glyceryl monostearate 4-8 per thousand, carboxymethyl chitosan 2-7 per thousand, ethanol 1-5 per thousand, glycerol 5-10 per thousand, coconut oil 1-5 per thousand, hydroxypropyl methyl cellulose 1-6 per thousand, hydroxyethyl cellulose 2-4 per thousand, carbomer 1-3 per thousand, lauryl betaine 1-5 per thousand, cold-extracted emblic extract 20-80 per thousand, sodium hyaluronate 0.1-0.5 per thousand and the balance of deionized water.
Preferably, the preparation method of the cold-extracted emblic leafflower fruit extract comprises the following steps:
step a): cleaning fresh fructus Phyllanthi fruit in clear water for 1-3 times to remove impurities; removing the cores of the emblic leafflower fruits, and preserving the separated emblic leafflower fruit pulp in vacuum at the temperature of 4 ℃;
step b): adding the phyllanthus emblica pulp into deionized water according to the mass ratio of the material liquid to the deionized water of 2:1, and crushing in a wall breaking machine until the phyllanthus emblica pulp is fully crushed; transferring the obtained feed liquid into an ultrasonic cell disruption instrument for treatment; filtering to obtain fructus Phyllanthi juice;
step c): centrifuging fructus Phyllanthi juice, adding the upper oil phase into saturated salt water, stirring, standing, and collecting the upper oil phase to obtain cold-extracted fructus Phyllanthi extract.
More preferably, the treatment time of the ultrasonic cell disruptor in step b) is 20 minutes.
More preferably, the speed of centrifugation in said step c) is 15000r/min, the time is 15min and the temperature is 4 ℃.
More preferably, the number of times of taking the upper oil phase after stirring and standing in the step c) is 2 to 5.
The invention also provides a preparation method of the bacteriostatic no-wash hand sanitizer containing the emblic leafflower fruit extract, which is characterized by comprising the following steps of:
step 1): dissolving alkyl glycoside Glucopon 600CSUP, glyceryl monostearate and carboxymethyl chitosan in ethanol, heating and stirring to form phase A;
step 2): dissolving glycerol, coconut oil, hydroxypropyl methyl cellulose, hydroxyethyl cellulose and carbomer in part of deionized water, heating and stirring to form phase B;
step 3): dissolving cold-extracted fructus Phyllanthi extract, lauryl betaine and sodium hyaluronate in the rest deionized water, and stirring to obtain phase C;
step 4): stirring A, B, C phase, mixing well, stirring well to transparent gel, and standing for 24 hr.
Preferably, the heating temperature in the step 1) is 50 ℃, and the stirring speed is 800 rpm.
Preferably, the heating temperature in the step 2) is 40 ℃, and the stirring speed is 800 rpm.
Preferably, the stirring speed in the step 3) is 800 rpm.
Compared with the prior art, the invention has the beneficial effects that:
the preferred formula of the bacteriostatic no-wash hand sanitizer prepared by the invention adopts the natural bacteriostatic agent of the cold-extracted emblic leafflower fruit extract, and the cold-extracted emblic leafflower fruit extract is rich in various alcohol, aldehyde, polyphenol and other components with bacteriostatic ability, so that the cold-extracted emblic leafflower fruit extract has extremely strong bacteriostatic and antioxidant activity and is an excellent natural bacteriostatic agent. The cold-extracted emblic extract has natural fragrance, can bring excellent sensory experience to people, and is pleasant.
Detailed Description
In order to make the invention more comprehensible, preferred embodiments are described in detail below.
The preparation process of the cold-extracted emblic leafflower fruit extract in each embodiment comprises the following steps:
1) selecting fresh, mature, undamaged and putrefactive fructus Phyllanthi, cleaning, and draining.
2) Removing kernel from fructus Phyllanthi, and vacuum storing the separated fructus Phyllanthi pulp at 4 deg.C.
3) Adding the phyllanthus emblica pulp into deionized water according to the addition amount of the material-liquid ratio of 2:1, and crushing in a wall breaking machine until the phyllanthus emblica pulp is fully crushed.
4) Transferring the wall-broken fructus Phyllanthi pulp to ultrasonic cell disruptor with specification of
Treating with the amplitude transformer for 20 minutes, and filtering to obtain crude phyllanthus emblica juice.
5) Centrifuging crude fructus Phyllanthi juice at 15000r/min for 15min at 4 deg.C.
6) Adding the upper oil phase into saturated salt solution, stirring, standing, collecting the upper oil phase, and repeating for 2-5 times to obtain cold-extracted fructus Phyllanthi extract.
The specifications of the other raw materials used in the examples and information on the manufacturers are shown in Table 1.
TABLE 1
| Name of raw materials | Purity of | Rank of | Manufacturer/agent |
| Alkyl glycoside Glucopon 600CSUP | - | Cosmetic grade | Basf-Fr |
| Glyceryl monostearate | ≥60.0％ | Cosmetic grade | UK He Da |
| Carboxymethyl chitosan | ≥90.0％ | Cosmetic grade | Adamas |
| Anhydrous ethanol | ≥99.5％ | Chemical purity | General-reagent |
| Glycerol | ≥98.0％ | Cosmetic grade | Adamas |
| Coconut oil | ≥99.0 | Cosmetic grade | Adamas |
| Hydroxypropyl methylcellulose | K75,15000mPa.s | Cosmetic grade | Adamas |
| Hydroxyethyl cellulose | 1500～2500mpas | Cosmetic grade | Adamas |
| Carbomer | ≥99.9％ | Cosmetic grade | Luobu (American Luobu) |
| Lauryl betaine | 30％in water | Cosmetic grade | Adamas |
| Hyaluronic acid sodium salt | ≥95％ | Cosmetic grade | Acros |
| Water (W) | Deionized water | Preparation in the laboratory |
Example 1
An antibacterial no-wash hand sanitizer containing cold-extracted fructus Phyllanthi extract is shown in Table 2.
TABLE 2
The preparation method of the bacteriostatic no-wash hand sanitizer containing the cold-extracted emblic leafflower fruit extract comprises the following steps:
step 1): and (3) mixing the phase A: dissolving alkyl glycoside Glucopon 600CSUP, glyceryl monostearate and carboxymethyl chitosan in anhydrous ethanol to obtain mixed solution A, heating at 50 deg.C, and stirring at 800 rpm;
step 2): and (3) mixing the phase B components: dissolving glycerol, coconut oil, hydroxypropyl methyl cellulose, hydroxyethyl cellulose and carbomer in part of deionized water to form a mixed solution B, heating to 40 ℃, and stirring at 800 rpm;
step 3): and (3) mixing the phase C components: dissolving cold-extracted fructus Phyllanthi extract, lauryl betaine and sodium hyaluronate in the rest deionized water to obtain mixed solution C, stirring at normal temperature and stirring speed of 800rpm
Step 4): and (3) stirring and mixing the mixed solution A, B, C uniformly, stirring the mixed solution uniformly to form transparent gel, and standing the gel for 24 hours to obtain the no-clean hand sanitizer.
The bacteriostatic no-wash hand sanitizer containing the cold-extracted emblic leafflower fruit extract obtained in the example 1 has no irritation to skin and has good biodegradability. Therefore, the bacteriostatic no-wash hand sanitizer containing the cold-extracted emblic leafflower fruit extract has good decontamination and sterilization capabilities and can be explained biologically.
Example 2
An antibacterial no-wash hand sanitizer containing cold-extracted fructus Phyllanthi extract is shown in Table 3.
TABLE 3
The preparation method of the bacteriostatic no-wash hand sanitizer containing the cold-extracted emblic leafflower fruit extract is the same as that of example 1.
The bacteriostatic no-wash hand sanitizer containing the cold-extracted emblic leafflower fruit extract obtained in the example 2 has good decontamination capability and certain fragrance.
Example 3
An antibacterial no-wash hand sanitizer containing cold-extracted fructus Phyllanthi extract is prepared from the following raw materials in percentage by weight as shown in Table 4.
TABLE 4
The preparation method of the bacteriostatic no-wash hand sanitizer containing the cold-extracted emblic leafflower fruit extract is the same as that of example 1.
Example 4
An antibacterial no-wash hand sanitizer containing cold-extracted fructus Phyllanthi extract is shown in Table 5.
TABLE 5
The preparation method of the bacteriostatic no-wash hand sanitizer containing the cold-extracted emblic leafflower fruit extract is the same as that of example 1.
The antibacterial leave-in hand sanitizer obtained in examples 1-4 is subjected to sensory evaluation of fragrance and skin feel, and subjects evaluate the feel of the antibacterial leave-in hand sanitizer in 1-5 points, wherein 1 point is dislike, 2 points are dislike, 3 points are general like, 4 points are like, and 5 points are like, and specific data are shown in table 6.
TABLE 6 fragrance and skin feel sensory evaluation scores for the bacteriostatic leave-in hand sanitizers from examples 1-4
| Evaluation of fragrance (score) | Skin feel evaluation (score) | |
| Example 1 | 3.2 | 4 |
| Example 2 | 3.6 | 4.4 |
| Example 3 | 3.8 | 4.2 |
| Example 4 | 4.6 | 4.4 |
As can be seen from Table 6, compared with examples 1-3, example 4 has better fragrance and skin feel, and it can be seen that the fragrance and skin feel of the bacteriostatic leave-on hand sanitizer can be well imparted by increasing the dosage of the extract of the emblic leafflower fruit.
The cold-extracted emblic extract is a natural bacteriostatic agent and has good fragrance. The antibacterial no-wash hand sanitizer has a good antibacterial effect, can moisten and moisturize hand skin while washing hands, and has natural emblic leafflower fruit fragrance. Besides the decontamination property and the bacteriostasis property, the product also has good fragrance and skin feel.
Claims (9)
1. An antibacterial leave-on hand sanitizer containing emblic extract is characterized in that raw materials comprise, by mass, 1-3% of alkyl glycoside Glucopon 600CSUP, 4-8% of glyceryl monostearate, 2-7% of carboxymethyl chitosan, 1-5% of ethanol, 5-10% of glycerol, 1-5% of coconut oil, 1-6% of hydroxypropyl methyl cellulose, 2-4% of hydroxyethyl cellulose, 1-3% of carbomer, 1-5% of lauryl betaine, 20-80% of cold-extracted emblic extract, 0.1-0.5% of sodium hyaluronate and the balance of deionized water.
2. The bacteriostatic no-wash hand sanitizer containing the emblic leafflower fruit extract according to claim 1, wherein the preparation method of the cold-extracted emblic leafflower fruit extract comprises the following steps:
step a): cleaning fresh fructus Phyllanthi fruit in clear water for 1-3 times to remove impurities; removing the cores of the emblic leafflower fruits, and preserving the separated emblic leafflower fruit pulp in vacuum at the temperature of 4 ℃;
step b): adding the phyllanthus emblica pulp into deionized water according to the mass ratio of the material liquid to the deionized water of 2:1, and crushing in a wall breaking machine until the phyllanthus emblica pulp is fully crushed; transferring the obtained feed liquid into an ultrasonic cell disruption instrument for treatment; filtering to obtain fructus Phyllanthi juice;
step c): centrifuging fructus Phyllanthi juice, adding the upper oil phase into saturated salt water, stirring, standing, and collecting the upper oil phase to obtain cold-extracted fructus Phyllanthi extract.
3. The bacteriostatic no-wash hand sanitizer containing emblic leafflower fruit extract according to claim 2, wherein the treatment time of the ultrasonic cell disruptor in the step b) is 20 minutes.
4. The bacteriostatic no-wash hand sanitizer containing emblic leafflower fruit extract according to claim 2, wherein the centrifugation in the step c) is carried out at 15000r/min for 15min at 4 ℃.
5. The bacteriostatic no-wash hand sanitizer containing emblic leafflower fruit extract according to claim 2, wherein the number of times of taking the upper oil phase after stirring and standing in the step c) is 2-5 times.
6. The preparation method of the bacteriostatic no-wash hand sanitizer containing the emblic leafflower fruit extract as claimed in any one of claims 1 to 5, which is characterized by comprising the following steps:
step 1): dissolving alkyl glycoside Glucopon 600CSUP, glyceryl monostearate and carboxymethyl chitosan in ethanol, heating and stirring to form phase A;
step 2): dissolving glycerol, coconut oil, hydroxypropyl methyl cellulose, hydroxyethyl cellulose and carbomer in part of deionized water, heating and stirring to form phase B;
step 3): dissolving cold-extracted fructus Phyllanthi extract, lauryl betaine and sodium hyaluronate in the rest deionized water, and stirring to obtain phase C;
step 4): stirring A, B, C phase, mixing well, stirring well to transparent gel, and standing for 24 hr.
7. The method of claim 6, wherein the heating temperature in step 1) is 50 ℃ and the stirring speed is 800 rpm.
8. The method of claim 6, wherein the heating temperature in step 2) is 40 ℃ and the stirring speed is 800 rpm.
9. The method according to claim 6, wherein the stirring speed in the step 3) is 800 rpm.
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|---|---|---|---|
| CN202011294031.4A CN112220722A (en) | 2020-11-18 | 2020-11-18 | Bacteriostatic no-wash hand sanitizer containing cold-extracted emblic leafflower fruit extract and preparation method thereof |
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| CN202011294031.4A CN112220722A (en) | 2020-11-18 | 2020-11-18 | Bacteriostatic no-wash hand sanitizer containing cold-extracted emblic leafflower fruit extract and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107594037A (en) * | 2017-11-06 | 2018-01-19 | 漳州开发区中欧食品产业发展中心 | Emblic plant herbal tea beverage and preparation method thereof |
| CN111419764A (en) * | 2020-03-19 | 2020-07-17 | 上海国兴医疗器械有限公司 | Antibacterial no-wash hand sanitizer and use method thereof |
| CN111920735A (en) * | 2020-08-21 | 2020-11-13 | 广东盛普生命科技有限公司 | Plant-derived anti-aging composition and application thereof |
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- 2020-11-18 CN CN202011294031.4A patent/CN112220722A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107594037A (en) * | 2017-11-06 | 2018-01-19 | 漳州开发区中欧食品产业发展中心 | Emblic plant herbal tea beverage and preparation method thereof |
| CN111419764A (en) * | 2020-03-19 | 2020-07-17 | 上海国兴医疗器械有限公司 | Antibacterial no-wash hand sanitizer and use method thereof |
| CN111920735A (en) * | 2020-08-21 | 2020-11-13 | 广东盛普生命科技有限公司 | Plant-derived anti-aging composition and application thereof |
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