CN111700824B - Alcohol-free sweet wormwood wax oil washing-free antibacterial hand sanitizer and preparation method thereof - Google Patents
Alcohol-free sweet wormwood wax oil washing-free antibacterial hand sanitizer and preparation method thereof Download PDFInfo
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- CN111700824B CN111700824B CN202010811239.2A CN202010811239A CN111700824B CN 111700824 B CN111700824 B CN 111700824B CN 202010811239 A CN202010811239 A CN 202010811239A CN 111700824 B CN111700824 B CN 111700824B
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- wormwood wax
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- 240000000011 Artemisia annua Species 0.000 title claims abstract description 60
- 235000001405 Artemisia annua Nutrition 0.000 title claims abstract description 59
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 49
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000007788 liquid Substances 0.000 claims abstract description 18
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 16
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 16
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 16
- 238000005406 washing Methods 0.000 claims abstract description 16
- 229920002545 silicone oil Polymers 0.000 claims abstract description 12
- 230000003110 anti-inflammatory effect Effects 0.000 claims abstract description 8
- 239000004094 surface-active agent Substances 0.000 claims abstract description 8
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 7
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 7
- 239000000022 bacteriostatic agent Substances 0.000 claims abstract description 6
- 229910021642 ultra pure water Inorganic materials 0.000 claims abstract description 5
- 239000012498 ultrapure water Substances 0.000 claims abstract description 5
- 239000000654 additive Substances 0.000 claims abstract description 3
- 230000000996 additive effect Effects 0.000 claims abstract description 3
- 240000001972 Gardenia jasminoides Species 0.000 claims abstract 3
- 239000003921 oil Substances 0.000 claims description 67
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000012071 phase Substances 0.000 claims description 18
- IBFYXTRXDNAPMM-BVTMAQQCSA-N Geniposide Chemical group O([C@@H]1OC=C([C@@H]2[C@H]1C(=CC2)CO)C(=O)OC)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O IBFYXTRXDNAPMM-BVTMAQQCSA-N 0.000 claims description 9
- IBFYXTRXDNAPMM-FZEIBHLUSA-N Geniposide Natural products COC(=O)C1=CO[C@@H](O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O)[C@H]2[C@@H]1CC=C2CO IBFYXTRXDNAPMM-FZEIBHLUSA-N 0.000 claims description 9
- VGLLGNISLBPZNL-RBUKDIBWSA-N arborescoside Natural products O=C(OC)C=1[C@@H]2C([C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)OC=1)=C(CO)CC2 VGLLGNISLBPZNL-RBUKDIBWSA-N 0.000 claims description 9
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical group CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 8
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 8
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 238000000746 purification Methods 0.000 claims description 7
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims description 6
- 229960001950 benzethonium chloride Drugs 0.000 claims description 6
- 230000001804 emulsifying effect Effects 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 5
- 239000012752 auxiliary agent Substances 0.000 claims description 4
- 239000004359 castor oil Substances 0.000 claims description 4
- 235000019438 castor oil Nutrition 0.000 claims description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 4
- 238000010025 steaming Methods 0.000 claims description 3
- 239000004593 Epoxy Substances 0.000 claims description 2
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 claims description 2
- 239000008346 aqueous phase Substances 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000000419 plant extract Substances 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 230000003020 moisturizing effect Effects 0.000 abstract description 4
- 241000894006 Bacteria Species 0.000 abstract description 3
- 230000000638 stimulation Effects 0.000 abstract description 3
- 230000001476 alcoholic effect Effects 0.000 abstract description 2
- 238000004140 cleaning Methods 0.000 abstract description 2
- 241000157835 Gardenia Species 0.000 description 9
- 239000002736 nonionic surfactant Substances 0.000 description 9
- 239000008367 deionised water Substances 0.000 description 6
- 229910021641 deionized water Inorganic materials 0.000 description 6
- -1 ester ether series Chemical class 0.000 description 6
- 239000000344 soap Substances 0.000 description 6
- 238000004090 dissolution Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 238000001035 drying Methods 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 241000222122 Candida albicans Species 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 229960001484 edetic acid Drugs 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000000967 suction filtration Methods 0.000 description 2
- 241000238876 Acari Species 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 229930015704 phenylpropanoid Natural products 0.000 description 1
- 125000001474 phenylpropanoid group Chemical group 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001846 repelling effect Effects 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Birds (AREA)
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Abstract
The invention provides a non-alcoholic sweet wormwood wax oil washing-free antibacterial hand sanitizer and a preparation method thereof, wherein the hand sanitizer consists of the following components in percentage by weight: 3-10% of water-soluble silicone oil, 0.1-0.5% of sweet wormwood wax oil, 0.1-0.5% of surfactant, 0.5-1% of glycerol, 0.2-0.5% of gardenia essence, 0.2-0.6% of water-soluble sodium carboxymethyl cellulose, 0.1-0.6% of bacteriostatic agent, 0.1-0.5% of antioxidant and 0.01-0.05% of anti-inflammatory additive, and adding ultrapure water to 100%. The sweet wormwood wax oil antibacterial hand-washing liquid has low viscosity, is easy to knead and quick to dry, and can kill various bacteria. The skin-care product does not contain ethanol, is added with a plurality of plant extract components, has no stimulation to skin, has moisturizing effect, and has double effects of cleaning and moisturizing.
Description
Technical Field
The invention relates to the field of washing, in particular to a wash-free antibacterial hand sanitizer of alcohol-free sweet wormwood wax oil and a preparation method thereof.
Background
Along with the progress of society, people attach more and more importance to personal hygiene, bottled liquid soap can be directly used after being simply pressed, and the problem of secondary pollution does not exist, so that the bottled liquid soap becomes a substitute for perfumed soap. Under the outdoor environment, the portable hand sanitizer with the no-clean function is required to be developed because of the limitation of water quantity. The sweet wormwood wax oil is a natural byproduct in the process of extracting sweet wormwood from plant sweet wormwood, and the main components of the sweet wormwood wax oil comprise terpenes, flavonoids, phenylpropanoids, fatty acids and biological phenols, and the sweet wormwood wax oil has natural antibacterial and anti-inflammatory components and has the functions of diminishing inflammation, repelling mosquitoes and removing mites. Because the plant extract oil is dissolved in ethanol, the conventional non-washing hand-washing liquid containing the plant extract oil generally contains ethanol, has a certain stimulation effect on skin and is not suitable for long-term use, so that development of the non-ethanol non-washing hand-washing liquid of the plant extract oil series is urgent.
Disclosure of Invention
The invention provides a non-alcoholic sweet wormwood wax oil washing-free antibacterial hand sanitizer and a preparation method thereof.
The technical scheme for realizing the invention is as follows:
a wash-free antibacterial hand sanitizer of alcohol-free sweet wormwood wax oil comprises the following components in percentage by weight: 3-10% of water-soluble silicone oil, 0.1-0.5% of sweet wormwood wax oil, 0.1-0.5% of surfactant, 0.5-1% of glycerol, 0.2-0.5% of gardenia essence, 0.2-0.6% of water-soluble sodium carboxymethyl cellulose, 0.1-0.6% of bacteriostatic agent, 0.1-0.5% of antioxidant and 0.01-0.05% of anti-inflammatory additive, and adding ultrapure water to 100%.
The bacteriostatic agent is at least one of benzalkonium chloride or benzethonium chloride, the antioxidant is EDTA disodium, the anti-inflammatory auxiliary agent is geniposide, and the surfactant is a nonionic surfactant.
The nonionic surfactant is nonionic ester ether series surfactant (castor oil/hydrogenated castor oil and epoxy condensate ethane, the type used in the examples).
The sweet wormwood wax oil is used after purification, and the purification method is as follows: dissolving sweet wormwood wax oil in a proper amount of ethanol, fully stirring and dissolving, carrying out suction filtration, filtering, steaming out ethanol by rotary steaming, and repeating for three times to obtain purified sweet wormwood wax oil.
Sweet wormwood wax oil and ethanol according to the following ratio of 1:10, stirring for 1h, and suction filtering.
The preparation method of the alcohol-free sweet wormwood wax oil washing-free antibacterial hand sanitizer comprises the following steps:
(1) Preparation of an oil phase: according to the formula amount, the sweet wormwood wax oil, the water-soluble silicone oil, the gardenia essence, the glycerol and the surfactant are stirred and mixed at normal temperature to obtain an oil phase solution;
(2) Preparation of an aqueous phase: fully dissolving water-soluble sodium carboxymethyl cellulose in water until the sodium carboxymethyl cellulose is clear to obtain a water phase solution;
(3) Adding the oil phase solution obtained in the step (1) into the water phase solution obtained in the step (2), adding a bacteriostatic agent, an antioxidant and an anti-inflammatory auxiliary agent, adding ultrapure water, stirring and emulsifying for 30min-1h at the normal temperature under the rotating speed of 2000r/s of an emulsifying machine, and then standing.
The dissolution temperature of the water-soluble sodium carboxymethyl cellulose in the step (2) is 50-60 ℃.
The invention has the beneficial effects that: by adopting a microemulsifying method, sweet wormwood wax oil is dissolved in water under the condition of no alcohol, and the sweet wormwood wax oil antibacterial hand-washing liquid has low viscosity, is easy to knead and quick-dry, and can kill various bacteria. The skin-care product does not contain ethanol, is added with a plurality of plant extract components, has no stimulation to skin, has moisturizing effect, and has double effects of cleaning and moisturizing.
Detailed Description
The technical solutions of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without any inventive effort, are intended to be within the scope of the invention.
The following examples are based on 100% by weight.
Example 1
The alcohol-free sweet wormwood wax oil antibacterial hand-washing liquid comprises, by weight, 3% of water-soluble silicone oil, 0.1% of sweet wormwood wax oil, 0.5% of glycerol, 0.2% of gardenia essence, 0.1% of ester ether series nonionic surfactant, 0.2% of water-soluble sodium carboxymethyl cellulose, 0.1% of benzethonium chloride, 0.1% of EDTA disodium, 0.01% of geniposide and the balance of deionized water.
Example 2
The alcohol-free sweet wormwood wax oil antibacterial hand-washing liquid comprises, by weight, 5% of water-soluble silicone oil, 0.2% of purified sweet wormwood wax oil, 0.3% of gardenia essence, 0.6% of glycerol, 0.2% of ester ether series nonionic surfactant, 0.3% of water-soluble sodium carboxymethyl cellulose, 0.3% of benzalkonium chloride, 0.2% of EDTA disodium, 0.02% of geniposide and the balance of deionized water.
The purification mode of the sweet wormwood wax oil is that the sweet wormwood wax oil is fully dissolved in ethanol and then is subjected to ultrasonic treatment for 1h, and the ethanol solvent is distilled out after the solution is subjected to suction filtration, so that the pure sweet wormwood wax oil is obtained.
Example 3
The alcohol-free sweet wormwood wax oil antibacterial hand-washing liquid comprises, by weight, 7% of water-soluble silicone oil, 0.3% of purified sweet wormwood wax oil, 0.7% of glycerol, 0.4% of gardenia essence, 0.3% of ester ether series nonionic surfactants, 0.4% of water-soluble sodium carboxymethyl cellulose, 0.4% of benzalkonium chloride/benzethonium chloride, 0.3% of EDTA disodium, 0.03% of geniposide and the balance of deionized water.
The purification method of the sweet wormwood wax oil comprises the following steps: sweet wormwood wax oil and ethanol are mixed according to the following ratio of 1:10 is dissolved in ethanol for 1h, and is filtered by suction after dissolution, and is repeated for three times. And (3) spin-evaporating the solution at 60 ℃ to obtain solvent ethanol to obtain purified sweet wormwood wax oil.
Example 4
The alcohol-free sweet wormwood wax oil antibacterial hand-washing liquid comprises, by weight, 8% of water-soluble silicone oil, 0.4% of sweet wormwood wax oil, 0.8% of glycerol, 0.5% of gardenia essence, 0.4% of ester ether series nonionic surfactant, 0.5% of water-soluble sodium carboxymethyl cellulose, 0.5% of benzalkonium chloride/benzethonium chloride, 0.4% of EDTA disodium, 0.04% of geniposide and the balance of deionized water.
The purification method of the sweet wormwood wax oil comprises the following steps: sweet wormwood wax oil and ethanol are mixed according to the following ratio of 1:10 is dissolved in ethanol for 1h, and is filtered by suction after dissolution, and is repeated for three times. And (3) spin-evaporating the solution at 60 ℃ to obtain solvent ethanol to obtain purified sweet wormwood wax oil.
The preparation method of the alcohol-free sweet wormwood wax oil antibacterial hand-washing liquid comprises the following steps: according to the formula amount, the sweet wormwood wax oil, the water-soluble silicone oil, the gardenia essence, the glycerol and the nonionic surfactant are stirred and mixed uniformly to form an oil phase. Dissolving water-soluble sodium carboxymethyl cellulose to obtain water phase. Mixing the oil phase and the water phase, adding benzalkonium chloride or benzethonium chloride, geniposide and EDTA disodium, adding water to 100%, and stirring and mixing to obtain the sweet wormwood wax oil antibacterial hand-washing liquid.
Example 5
The alcohol-free washing-free antibacterial hand sanitizer of sweet wormwood wax oil in the embodiment comprises, by weight, 10% of water-soluble silicone oil, 0.5% of sweet wormwood wax oil, 1% of glycerol, 0.3% of gardenia essence, 0.5% of ester ether series nonionic surfactant, 0.6% of water-soluble sodium carboxymethyl cellulose, 0.6% of benzalkonium chloride, 0.5% of EDTA (ethylene diamine tetraacetic acid), 0.05% of geniposide and the balance of deionized water.
The purification method of the sweet wormwood wax oil comprises the following steps: sweet wormwood wax oil and ethanol are mixed according to the following ratio of 1:10 is dissolved in ethanol for 1h, and is filtered by suction after dissolution, and is repeated for three times. And (3) spin-evaporating the solution at 60 ℃ to obtain solvent ethanol to obtain purified sweet wormwood wax oil.
The invention also provides a preparation method of the alcohol-free sweet wormwood wax oil hand sanitizer, and the sweet wormwood wax oil, the water-soluble silicone oil, the gardenia essence, the glycerol and the nonionic surfactant are uniformly stirred and mixed according to the formula amount to prepare an oil phase. Dissolving water-soluble sodium carboxymethyl cellulose in water at 60deg.C, clarifying to obtain water phase. Mixing the oil phase and the water phase, adding geniposide, EDTA disodium and benzalkonium chloride, emulsifying by an emulsifying machine, adding the rest deionized water, stirring, mixing, and standing.
Effect examples
The hand-washing-free liquid soap has the effects of sterilization and bacteriostasis:
table 1 diameter of antibacterial ring (mm) of hand cleanser
The hand sanitizer has antibacterial effect on staphylococcus aureus, escherichia coli and candida albicans, and the diameter result of the antibacterial ring meets the requirements of disinfection technical Specification (2002 edition).
TABLE 2 antibacterial Rate of hand sanitizer against different bacteria (%)
The hand sanitizer has the functions of 2min,5min,10min and 20min, has the average antibacterial rate of more than or equal to 99.97 percent on staphylococcus aureus, escherichia coli and candida albicans, meets the requirements of the sanitary standard of disposable sanitary products (GB 15979-2002), and has stronger antibacterial effect.
Compared with the commercial alcohol hand-washing-free liquid soap, the sweet wormwood wax oil hand-washing-free liquid soap can still obtain better antibacterial effect under the condition of no alcohol.
TABLE 3 kneading drying results
2-3ml of the hand sanitizer is placed on the palm of a user, timing is started when spreading and rubbing are started, thorough drying timing is finished, and the drying time of the hand sanitizer is about 10-20 s.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Claims (3)
1. The alcohol-free sweet wormwood wax oil washing-free antibacterial hand-washing liquid is characterized by comprising the following components in percentage by weight: 3-10% of water-soluble silicone oil, 0.1-0.5% of sweet wormwood wax oil, 0.1-0.5% of surfactant, 0.5-1% of glycerol, 0.2-0.5% of gardenia essence, 0.2-0.6% of water-soluble sodium carboxymethyl cellulose, 0.1-0.6% of bacteriostatic agent, 0.1-0.5% of antioxidant, 0.01-0.05% of anti-inflammatory additive and adding ultrapure water to 100%; the sweet wormwood wax oil is used after being purified, and the purification method comprises the following steps: dissolving sweet wormwood wax oil in a proper amount of ethanol, wherein the sweet wormwood wax oil and the ethanol are prepared according to the following steps of 1:10, fully stirring and dissolving, filtering, steaming ethanol out after filtering, and repeating for three times to obtain purified sweet wormwood wax oil;
the preparation method comprises the following steps:
(1) Preparation of an oil phase: according to the formula amount, the sweet wormwood wax oil, the water-soluble silicone oil, the gardenia essence, the glycerol and the surfactant are stirred and mixed at normal temperature to obtain an oil phase solution;
(2) Preparation of an aqueous phase: fully dissolving water-soluble sodium carboxymethyl cellulose in water until the sodium carboxymethyl cellulose is clear to obtain a water phase solution;
(3) Adding the oil phase solution obtained in the step (1) into the water phase solution obtained in the step (2), adding a bacteriostatic agent, an antioxidant and an anti-inflammatory auxiliary agent, adding ultrapure water, stirring and emulsifying for 30min-1h at the normal temperature by using an emulsifying machine at the rotating speed of 2000r/s, and then standing;
the antibacterial agent is at least one of benzalkonium chloride or benzethonium chloride, the antioxidant is EDTA disodium, the anti-inflammatory auxiliary agent is geniposide, and the surfactant is castor oil/hydrogenated castor oil and epoxy condensate ethane.
2. The alcohol-free sweet wormwood wax oil washing-free antibacterial hand-washing liquid according to claim 1, which is characterized in that: sweet wormwood wax oil and ethanol according to the following ratio of 1:10, stirring for 1h, and suction filtering.
3. The alcohol-free sweet wormwood wax oil washing-free antibacterial hand-washing liquid according to claim 1, which is characterized in that: the temperature for dissolving the water-soluble sodium carboxymethyl cellulose in the step (2) is 50-60 ℃.
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