CN111700824A - Alcohol-free sweet wormwood wax oil washing-free antibacterial hand sanitizer and preparation method thereof - Google Patents
Alcohol-free sweet wormwood wax oil washing-free antibacterial hand sanitizer and preparation method thereof Download PDFInfo
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- CN111700824A CN111700824A CN202010811239.2A CN202010811239A CN111700824A CN 111700824 A CN111700824 A CN 111700824A CN 202010811239 A CN202010811239 A CN 202010811239A CN 111700824 A CN111700824 A CN 111700824A
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- sweet wormwood
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- wax oil
- water
- hand sanitizer
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- 240000000011 Artemisia annua Species 0.000 title claims abstract description 61
- 235000001405 Artemisia annua Nutrition 0.000 title claims abstract description 60
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 45
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 36
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 14
- 230000003385 bacteriostatic effect Effects 0.000 claims abstract description 14
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 14
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 14
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 14
- 229920002545 silicone oil Polymers 0.000 claims abstract description 12
- 239000004094 surface-active agent Substances 0.000 claims abstract description 9
- 230000003110 anti-inflammatory effect Effects 0.000 claims abstract description 8
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 7
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 7
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 7
- 239000000022 bacteriostatic agent Substances 0.000 claims abstract description 7
- 229910021642 ultra pure water Inorganic materials 0.000 claims abstract description 5
- 239000012498 ultrapure water Substances 0.000 claims abstract description 5
- 240000001972 Gardenia jasminoides Species 0.000 claims abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000012071 phase Substances 0.000 claims description 18
- 239000000686 essence Substances 0.000 claims description 11
- 239000002736 nonionic surfactant Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- IBFYXTRXDNAPMM-BVTMAQQCSA-N Geniposide Chemical group O([C@@H]1OC=C([C@@H]2[C@H]1C(=CC2)CO)C(=O)OC)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O IBFYXTRXDNAPMM-BVTMAQQCSA-N 0.000 claims description 9
- IBFYXTRXDNAPMM-FZEIBHLUSA-N Geniposide Natural products COC(=O)C1=CO[C@@H](O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O)[C@H]2[C@@H]1CC=C2CO IBFYXTRXDNAPMM-FZEIBHLUSA-N 0.000 claims description 9
- VGLLGNISLBPZNL-RBUKDIBWSA-N arborescoside Natural products O=C(OC)C=1[C@@H]2C([C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)OC=1)=C(CO)CC2 VGLLGNISLBPZNL-RBUKDIBWSA-N 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 9
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 8
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 8
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 8
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 238000000967 suction filtration Methods 0.000 claims description 8
- -1 ester ether series Chemical class 0.000 claims description 7
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims description 6
- 229960001950 benzethonium chloride Drugs 0.000 claims description 6
- 230000001804 emulsifying effect Effects 0.000 claims description 6
- 238000002390 rotary evaporation Methods 0.000 claims description 3
- 239000008346 aqueous phase Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 5
- 239000000419 plant extract Substances 0.000 abstract description 5
- 241000894006 Bacteria Species 0.000 abstract description 3
- 230000000638 stimulation Effects 0.000 abstract description 3
- 238000004140 cleaning Methods 0.000 abstract description 2
- 239000006071 cream Substances 0.000 abstract description 2
- 230000009977 dual effect Effects 0.000 abstract description 2
- 230000003020 moisturizing effect Effects 0.000 abstract description 2
- 239000003921 oil Substances 0.000 description 52
- 241000157835 Gardenia Species 0.000 description 9
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 8
- 239000008367 deionised water Substances 0.000 description 6
- 229910021641 deionized water Inorganic materials 0.000 description 6
- 239000002904 solvent Substances 0.000 description 4
- 238000009210 therapy by ultrasound Methods 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 241000222122 Candida albicans Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 1
- 241000238876 Acari Species 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 description 1
- 229960004191 artemisinin Drugs 0.000 description 1
- 229930101531 artemisinin Natural products 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229930015704 phenylpropanoid Natural products 0.000 description 1
- 125000001474 phenylpropanoid group Chemical group 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001846 repelling effect Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Birds (AREA)
- Chemical & Material Sciences (AREA)
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- Dispersion Chemistry (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides an alcohol-free sweet wormwood wax oil washing-free antibacterial hand sanitizer and a preparation method thereof, wherein the alcohol-free sweet wormwood wax oil washing-free antibacterial hand sanitizer comprises the following components in percentage by weight: 3-10% of water-soluble silicone oil, 0.1-0.5% of sweet wormwood herb wax oil, 0.1-0.5% of surfactant, 0.5-1% of glycerol, 0.2-0.5% of gardenia essence, 0.2-0.6% of water-soluble sodium carboxymethylcellulose, 0.1-0.6% of bacteriostatic agent, 0.1-0.5% of antioxidant, 0.01-0.05% of anti-inflammatory auxiliary agent and ultrapure water added to 100%. The sweet wormwood wax oil bacteriostatic no-wash hand sanitizer has low viscosity, is easy to rub and dry, and can kill various bacteria. The skin-moistening cream does not contain ethanol, is added with various plant extracts, has no stimulation to skin, has the effects of moisturizing and moistening, and has the dual effects of cleaning and moistening skin.
Description
Technical Field
The invention relates to the field of washing, in particular to an alcohol-free sweet wormwood wax oil washing-free antibacterial hand sanitizer and a preparation method thereof.
Background
Along with the progress of society, people attach more and more importance to personal hygiene, and bottled hand sanitizer can be directly used after being simply pressed, does not have the problem of secondary pollution, and has become a substitute of soap. In outdoor environment, because of the limitation of water amount, a portable hand sanitizer with no-clean function needs to be developed. The sweet wormwood wax oil is a natural byproduct in the process of extracting the artemisinin from the plant sweet wormwood, mainly comprises terpenes, flavonoids, phenylpropanoids, fatty acids and biological phenol, has natural antibacterial and anti-inflammatory components, and has the functions of diminishing inflammation, repelling mosquitoes and removing mites. Because the plant extract oil needs to be dissolved in the ethanol, the common non-washing hand sanitizer containing the plant extract oil generally contains the alcohol, has a certain stimulation effect on the skin, and is not suitable for long-term use, so that the development of the plant extract oil series of non-alcohol non-washing hand sanitizers is urgent.
Disclosure of Invention
The invention provides an alcohol-free sweet wormwood wax oil washing-free antibacterial hand sanitizer and a preparation method thereof.
The technical scheme for realizing the invention is as follows:
an alcohol-free sweet wormwood wax oil washing-free antibacterial hand sanitizer comprises the following components in percentage by weight: 3-10% of water-soluble silicone oil, 0.1-0.5% of sweet wormwood herb wax oil, 0.1-0.5% of surfactant, 0.5-1% of glycerol, 0.2-0.5% of gardenia essence, 0.2-0.6% of water-soluble sodium carboxymethylcellulose, 0.1-0.6% of bacteriostatic agent, 0.1-0.5% of antioxidant, 0.01-0.05% of anti-inflammatory auxiliary agent and ultrapure water added to 100%.
The bacteriostatic agent is at least one of benzalkonium chloride or benzethonium chloride, the antioxidant is disodium EDTA, the anti-inflammatory auxiliary agent is geniposide, and the surfactant is a nonionic surfactant.
The nonionic surfactant is a nonionic ester ether series surfactant (castor oil/hydrogenated castor oil and ethylene oxide condensate, which is used in examples).
The sweet wormwood wax oil is used after being purified, and the purification method comprises the following steps: dissolving sweet wormwood wax oil in an appropriate amount of ethanol, fully stirring and dissolving, performing suction filtration, filtering, performing rotary evaporation to evaporate ethanol, and repeating for three times to obtain purified sweet wormwood wax oil.
Mixing sweet wormwood wax oil and ethanol according to the weight ratio of 1: dissolving at the ratio of 10, stirring for 1h, and performing suction filtration.
The preparation method of the alcohol-free sweet wormwood wax oil washing-free antibacterial hand sanitizer comprises the following steps:
(1) preparation of oil phase: according to the formula amount, sweet wormwood wax oil, water-soluble silicone oil, gardenia essence, glycerol and surfactant are stirred and mixed at normal temperature to obtain oil phase solution;
(2) preparation of the aqueous phase: fully dissolving water-soluble sodium carboxymethylcellulose in water until the solution is clear to obtain a water phase solution;
(3) adding the oil phase solution obtained in the step (1) into the water phase solution obtained in the step (2), adding a bacteriostatic agent, an antioxidant and an anti-inflammatory auxiliary agent, adding ultrapure water, stirring and emulsifying at the normal temperature for 30min-1h at the rotating speed of 2000r/s by using an emulsifying machine, and standing.
The temperature for dissolving the water-soluble sodium carboxymethyl cellulose in the step (2) is 50-60 ℃.
The invention has the beneficial effects that: by adopting a micro-emulsification method, the sweet wormwood wax oil is dissolved in water under the condition of no alcohol, and the sweet wormwood wax oil bacteriostatic no-wash hand sanitizer has low viscosity, is easy to rub and dry, and can kill various bacteria. The skin-moistening cream does not contain ethanol, is added with various plant extracts, has no stimulation to skin, has the effects of moisturizing and moistening, and has the dual effects of cleaning and moistening skin.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive effort based on the embodiments of the present invention, are within the scope of the present invention.
The following examples are all based on 100% by weight.
Example 1
The alcohol-free sweet wormwood wax oil bacteriostatic no-wash hand sanitizer comprises, by weight, 3% of water-soluble silicone oil, 0.1% of sweet wormwood wax oil, 0.5% of glycerol, 0.2% of gardenia essence, 0.1% of ester ether series nonionic surfactant, 0.2% of water-soluble sodium carboxymethyl cellulose, 0.1% of benzethonium chloride, 0.1% of disodium EDTA, 0.01% of geniposide, and the balance of deionized water.
Example 2
The alcohol-free sweet wormwood wax oil bacteriostatic no-wash hand sanitizer comprises, by weight, 5% of water-soluble silicone oil, 0.2% of purified sweet wormwood wax oil, 0.3% of gardenia essence, 0.6% of glycerol, 0.2% of ester ether series nonionic surfactant, 0.3% of water-soluble sodium carboxymethyl cellulose, 0.3% of benzalkonium chloride, 0.2% of disodium EDTA, 0.02% of geniposide, and the balance of deionized water.
The method for purifying the sweet wormwood wax oil comprises the steps of fully dissolving the sweet wormwood wax oil in ethanol, performing ultrasonic treatment for 1h, performing suction filtration on the solution, and performing rotary evaporation on an ethanol solvent to obtain a pure sweet wormwood wax oil product.
Example 3
The alcohol-free sweet wormwood wax oil bacteriostatic no-wash hand sanitizer provided by the embodiment comprises, by weight, 7% of water-soluble silicone oil, 0.3% of purified sweet wormwood wax oil, 0.7% of glycerol, 0.4% of gardenia essence, 0.3% of ester ether series nonionic surfactant, 0.4% of water-soluble sodium carboxymethyl cellulose, 0.4% of benzalkonium chloride/benzethonium chloride, 0.3% of disodium EDTA, 0.03% of geniposide, and the balance of deionized water.
The method for purifying the sweet wormwood wax oil comprises the following steps: mixing sweet wormwood wax oil and ethanol according to the weight ratio of 1: dissolving 10 parts of the raw materials in ethanol, performing ultrasonic treatment for 1 hour, performing suction filtration after dissolution, and repeating the steps for three times. And (3) distilling the solution at 60 ℃ to remove the solvent ethanol to obtain the purified sweet wormwood wax oil.
Example 4
The alcohol-free sweet wormwood wax oil bacteriostatic no-wash hand sanitizer provided by the embodiment comprises, by weight, 8% of water-soluble silicone oil, 0.4% of sweet wormwood wax oil, 0.8% of glycerol, 0.5% of gardenia essence, 0.4% of ester ether series nonionic surfactant, 0.5% of water-soluble sodium carboxymethyl cellulose, 0.5% of benzalkonium chloride/benzethonium chloride, 0.4% of disodium EDTA, 0.04% of geniposide, and the balance of deionized water.
The method for purifying the sweet wormwood wax oil comprises the following steps: mixing sweet wormwood wax oil and ethanol according to the weight ratio of 1: dissolving 10 parts of the raw materials in ethanol, performing ultrasonic treatment for 1 hour, performing suction filtration after dissolution, and repeating the steps for three times. And (3) distilling the solution at 60 ℃ to remove the solvent ethanol to obtain the purified sweet wormwood wax oil.
The preparation method of the alcohol-free sweet wormwood wax oil bacteriostatic no-wash hand sanitizer comprises the following steps: according to the formula, sweet wormwood wax oil, water-soluble silicone oil, gardenia essence, glycerol and a nonionic surfactant are stirred and mixed uniformly to form an oil phase. Dissolving water-soluble sodium carboxymethylcellulose to obtain water phase. Mixing the oil phase and the water phase, adding benzalkonium chloride or benzethonium chloride, geniposide and EDTA disodium, adding water to 100%, and stirring and mixing to obtain the sweet wormwood wax oil antibacterial no-clean hand sanitizer.
Example 5
The sweet wormwood wax oil alcohol-free no-clean antibacterial hand sanitizer disclosed by the embodiment comprises, by weight, 10% of water-soluble silicone oil, 0.5% of sweet wormwood wax oil, 1% of glycerol, 0.3% of gardenia essence, 0.5% of ester ether series nonionic surfactant, 0.6% of water-soluble sodium carboxymethylcellulose, 0.6% of benzalkonium chloride, 0.5% of disodium EDTA (ethylene diamine tetraacetic acid), 0.05% of geniposide and the balance of deionized water.
The method for purifying the sweet wormwood wax oil comprises the following steps: mixing sweet wormwood wax oil and ethanol according to the weight ratio of 1: dissolving 10 parts of the raw materials in ethanol, performing ultrasonic treatment for 1 hour, performing suction filtration after dissolution, and repeating the steps for three times. And (3) distilling the solution at 60 ℃ to remove the solvent ethanol to obtain the purified sweet wormwood wax oil.
The invention also provides a preparation method of the alcohol-free sweet wormwood wax oil hand sanitizer, which is characterized in that according to the formula, sweet wormwood wax oil, water-soluble silicone oil, gardenia essence, glycerol and a nonionic surfactant are stirred and mixed uniformly to prepare an oil phase. Dissolving water-soluble sodium carboxymethylcellulose in water at 60 deg.C, clarifying, and making into water phase. Mixing the oil phase and the water phase, adding geniposide, disodium EDTA and benzalkonium chloride, emulsifying with an emulsifying machine, adding deionized water, stirring, mixing, and standing.
Effects of the embodiment
The no-clean hand sanitizer has the following sterilization and bacteriostasis effects:
TABLE 1 antibacterial Ring diameter (mm) of hand cleanser
The hand sanitizer has the bacteriostatic action on the antibacterial ring diameter results of staphylococcus aureus, escherichia coli and candida albicans which meet the requirements of disinfection technical specifications (2002 edition).
TABLE 2 antibacterial ratio (%) of the lotions to different bacteria
The average bacteriostasis rates of the hand sanitizer on staphylococcus aureus, escherichia coli and candida albicans are more than or equal to 99.97 percent after the hand sanitizer acts for 2min, 5min, 10min and 20min, the requirements of sanitary standards for disposable sanitary products (GB 15979-.
Compared with the commercially available alcohol type no-clean hand sanitizer, the sweet wormwood wax oil no-clean hand sanitizer can still obtain a good antibacterial effect under the condition of no alcohol.
TABLE 3 rub drying results
Placing 2-3ml of the hand sanitizer in the palm of a user, starting timing when spreading and rubbing are started, and finishing the thorough drying and timing, wherein the drying time of the hand sanitizer is about 10-20 s.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (7)
1. The alcohol-free sweet wormwood wax oil washing-free antibacterial hand sanitizer is characterized by comprising the following components in percentage by weight: 3-10% of water-soluble silicone oil, 0.1-0.5% of sweet wormwood herb wax oil, 0.1-0.5% of surfactant, 0.5-1% of glycerol, 0.2-0.5% of gardenia essence, 0.2-0.6% of water-soluble sodium carboxymethylcellulose, 0.1-0.6% of bacteriostatic agent, 0.1-0.5% of antioxidant, 0.01-0.05% of anti-inflammatory auxiliary agent and ultrapure water added to 100%.
2. The alcohol-free sweet wormwood wax oil washing-free bacteriostatic hand sanitizer according to claim 1, which is characterized in that: the bacteriostatic agent is at least one of benzalkonium chloride or benzethonium chloride, the antioxidant is disodium EDTA, the anti-inflammatory auxiliary agent is geniposide, and the surfactant is a nonionic surfactant.
3. The alcohol-free sweet wormwood wax oil washing-free bacteriostatic hand sanitizer according to claim 2, which is characterized in that: the nonionic surfactant is nonionic ester ether series surfactant.
4. The alcohol-free sweet wormwood wax oil washing-free bacteriostatic hand sanitizer according to claim 1, which is characterized in that: the sweet wormwood wax oil is used after being purified, and the purification method comprises the steps of dissolving the sweet wormwood wax oil in a proper amount of ethanol, fully stirring and dissolving, then carrying out suction filtration, filtering, carrying out rotary evaporation to evaporate the ethanol, and repeating for three times to obtain the purified sweet wormwood wax oil.
5. The alcohol-free sweet wormwood wax oil washing-free bacteriostatic hand sanitizer according to claim 4, wherein the alcohol-free sweet wormwood wax oil washing-free bacteriostatic hand sanitizer is characterized in that: mixing sweet wormwood wax oil and ethanol according to the weight ratio of 1: dissolving at the ratio of 10, stirring for 1h, and performing suction filtration.
6. A method for preparing the alcohol-free sweet wormwood wax oil no-clean bacteriostatic hand sanitizer according to any one of claims 1 to 5, which is characterized by comprising the following steps:
(1) preparation of oil phase: according to the formula amount, sweet wormwood wax oil, water-soluble silicone oil, gardenia essence, glycerol and surfactant are stirred and mixed at normal temperature to obtain oil phase solution;
(2) preparation of the aqueous phase: fully dissolving water-soluble sodium carboxymethylcellulose in water until the solution is clear to obtain a water phase solution;
(3) adding the oil phase solution obtained in the step (1) into the water phase solution obtained in the step (2), adding a bacteriostatic agent, an antioxidant and an anti-inflammatory auxiliary agent, adding ultrapure water, stirring and emulsifying at the normal temperature of 2000r/s for 30min-1h by using an emulsifying machine, and standing.
7. The method of claim 6, wherein: the temperature for dissolving the water-soluble sodium carboxymethyl cellulose in the step (2) is 50-60 ℃.
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