CN112206192B - Deep acne-removing facial cleanser and preparation method thereof - Google Patents
Deep acne-removing facial cleanser and preparation method thereof Download PDFInfo
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- CN112206192B CN112206192B CN202011199486.8A CN202011199486A CN112206192B CN 112206192 B CN112206192 B CN 112206192B CN 202011199486 A CN202011199486 A CN 202011199486A CN 112206192 B CN112206192 B CN 112206192B
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- 206010000496 acne Diseases 0.000 title claims abstract description 134
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- 238000002156 mixing Methods 0.000 claims abstract description 45
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- DVEKCXOJTLDBFE-UHFFFAOYSA-N n-dodecyl-n,n-dimethylglycinate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC([O-])=O DVEKCXOJTLDBFE-UHFFFAOYSA-N 0.000 claims abstract description 9
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 8
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A—HUMAN NECESSITIES
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- A61Q19/00—Preparations for care of the skin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention provides deep acne-removing facial cleanser and a preparation method thereof, wherein the facial cleanser comprises the following substances in parts by weight: 15-20 parts of diatomite, 3-5 parts of potassium laurylphosphate, 2-3 parts of glycerol, 10-15 parts of propylene glycol, 3-5 parts of cocamidopropyl beet, 3-5 parts of dodecyl dimethyl betaine, 1-2 parts of N-lauroyl sarcosine sodium, 150-160 parts of deionized water and 15-20 parts of acne-removing gel liquid; the acne-removing gel liquid is prepared by mixing a traditional Chinese medicine extract and a polyvinyl alcohol aqueous solution. The deep acne-removing type facial cleanser can deeply clean and act on the inside of skin, and meanwhile, effective substances in traditional Chinese medicine materials are mainly adopted for extraction and treatment, so that the facial cleanser has a good acne-removing effect.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to deep acne-removing facial cleanser and a preparation method thereof.
Background
Acne, also known as young acne, is a chronic inflammation of hair follicles and sebaceous glands. Is generally applied to the fat-rich area of skin, such as forehead, nose bridge, chest and back. With self-limiting, polymorphic lesions such as acne, papules, pustules, nodules, often accompanied by seborrhea. Following puberty, acne gradually diminishes as hormone secretion equilibrates. While serious acne skin diseases require antibiotics, hormones and other medicines for treatment, aiming at mild acne and skin possibly inducing excessive secretion of grease of the acne, prevention and auxiliary treatment are required by diet and daily cosmetics, and skin grease balance is regulated by utilizing the advantages of sterilization, moisture preservation, cleaning and the like of functional cosmetics.
The main formulation of the acne-removing cosmetic is generally acne-removing facial cleanser, acne-removing cream, acne-removing essence and the like, and the acne is removed by using the oil-controlling facial cleanser to clean the acne-removing cosmetic, and then smearing the acne-removing cream and other skin care products. The existing acne removing product adopts the cream formulation, but one of the reasons for inducing acne is excessive grease secretion, so the acne removing cream has poor treatment effect and unsatisfactory use feeling, and meanwhile, the traditional acne removing product mainly treats the skin surface and has poor treatment effect. Antibiotics are also commonly used for treatment in the existing acne-removing products, but the products can rapidly treat acne, but cosmetics are daily necessities, and long-term use of the antibiotics cosmetics can cause contact dermatitis and have side effects of erythema, edema, erosion, desquamation and the like. Even more severe cases may cause contact dermatitis and other skin diseases, causing serious damage to human endocrine and skin, so it is necessary to produce a suitable, mild acne-removing product.
Disclosure of Invention
The present invention aims to solve at least one of the technical problems existing in the prior art.
In view of the above, the invention provides a deep acne-removing facial cleanser and a preparation method thereof, which can deeply clean and act on the inside of skin, and simultaneously extract and treat effective substances in traditional Chinese medicine materials mainly, so that the facial cleanser has a good acne-removing effect.
According to the deep acne-removing type facial cleanser disclosed by the embodiment of the first aspect of the invention, the facial cleanser comprises the following substances in parts by weight:
15-20 parts of diatomite, 3-5 parts of potassium laurylphosphate, 2-3 parts of glycerol, 10-15 parts of propylene glycol, 3-5 parts of cocamidopropyl beet, 3-5 parts of dodecyl dimethyl betaine, 1-2 parts of N-lauroyl sarcosine sodium, 150-160 parts of deionized water and 15-20 parts of acne-removing gel liquid; the acne-removing gel liquid is prepared by mixing a traditional Chinese medicine extract and a polyvinyl alcohol aqueous solution.
According to the deep acne-removing type facial cleanser provided by the embodiment of the invention, the traditional Chinese medicine extracting solution is adopted as a main acne-removing material to extract and prepare gel liquid, the acne-removing treatment effect of an acne-removing product on skin is improved through the coating property and the permeability of the gel liquid, meanwhile, the traditional Chinese medicine acne-removing extracting solution is adopted in the technical scheme, the metabolism of a human body can be effectively regulated through oral administration, and the main pathogenic bacteria of acne can be inhibited through external coating, cleaning and other schemes, so that the acne treatment effect is achieved.
The deep acne-removing facial cleanser according to the embodiment of the invention can also have the following additional technical characteristics:
according to an embodiment of the invention, the deep acne-removing facial cleanser further comprises: and the transdermal modified liquid is equal to the acne-removing gel liquid in weight part.
According to one embodiment of the invention, the preparation steps of the acne-removing gel solution are as follows: (1) taking traditional Chinese medicines, grinding and sieving, and collecting sieving particles; (2) Taking the sieved particles, using deionized water as a medium, carrying out water extraction treatment, and collecting water extract; (3) Adding the water extract into the polyvinyl alcohol solution, stirring, mixing and dispersing by ultrasonic to obtain the acne-removing gel solution.
According to one embodiment of the invention, the traditional Chinese medicine comprises a mixture of any one or more of astragalus membranaceus, phellodendron amurense and ulmus pumila.
According to one embodiment of the invention, the screened particle size is 500 mesh.
According to one embodiment of the invention, the preparation steps of the transdermal modification liquid are as follows: (1) Mixing the materials, grinding, sieving, and collecting the ground particles; (2) Adding the ground particles into a volatile oil extractor, extracting, collecting a mixed solution, extracting the mixed solution with anhydrous diethyl ether, collecting an extract, drying the extract with anhydrous sodium sulfate, volatilizing and drying at room temperature, and collecting volatile essential oil; (3) And stirring and mixing the emulsion and the volatile essential oil, and performing ultrasonic dispersion to obtain the transdermal modified liquid.
According to one embodiment of the invention, the medicinal material comprises one or a mixture of two of weeping forsythia seeds and angelica.
According to one embodiment of the invention, the emulsion comprises span-80, tween-80 and deionized water mixed according to a mass ratio of 1:2:15.
The preparation method of the deep acne-removing facial cleanser according to the embodiment of the second aspect of the invention comprises the following specific preparation steps: s1, firstly stirring and mixing the transdermal modification liquid, the acne-removing gel liquid and the diatomite, placing the mixture in a homogenizer, homogenizing the mixture at room temperature, and collecting homogenized slurry; s2, stirring and mixing glycerol, propylene glycol and deionized water according to a formula, heating, preserving heat and dissolving, and collecting a dissolving solution; s3, adding potassium laurylphosphate, cocamidopropyl beet, dodecyl dimethyl betaine and N-lauroyl sarcosine sodium into the solution, stirring and mixing, standing and cooling, and collecting an intermediate mixed solution; and S4, adding the homogeneous slurry into the intermediate mixed solution, stirring and mixing, performing ultrasonic dispersion at room temperature, standing and defoaming, and filling and packaging to obtain the deep acne-removing facial cleanser.
Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.
Drawings
The foregoing and/or additional aspects and advantages of the invention will become apparent and may be better understood from the following description of embodiments taken in conjunction with the accompanying drawings in which:
fig. 1 is a flowchart of a preparation method of the deep acne-removing type facial cleanser according to the invention.
Detailed Description
Embodiments of the present invention are described in detail below, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout. The embodiments described below by referring to the drawings are illustrative only and are not to be construed as limiting the invention.
The deep acne-removing type facial cleanser according to the embodiment of the invention is described in detail below.
The deep acne-removing type facial cleanser provided by the embodiment of the invention comprises the following substances in parts by weight:
15-20 parts of diatomite, 3-5 parts of potassium laurylphosphate, 2-3 parts of glycerol, 10-15 parts of propylene glycol, 3-5 parts of cocamidopropyl beet, 3-5 parts of dodecyl dimethyl betaine, 1-2 parts of N-lauroyl sarcosine sodium, 150-160 parts of deionized water and 15-20 parts of acne-removing gel liquid; the acne-removing gel liquid is prepared by mixing a traditional Chinese medicine extract and a polyvinyl alcohol aqueous solution.
According to the deep acne-removing facial cleanser provided by the embodiment of the invention, the traditional Chinese medicine extracting solution is adopted as a main acne-removing material to extract and prepare gel liquid, the acne-removing treatment effect of an acne-removing product on skin is improved through the coating property and the permeability of the gel liquid, meanwhile, the traditional Chinese medicine acne-removing extracting solution is adopted in the technical scheme, the metabolism of a human body can be effectively regulated through oral administration, and the main pathogenic bacteria of acne can be inhibited through external coating, cleaning and other schemes, so that the acne-removing effect is achieved.
According to one embodiment of the invention, the deep acne-removing facial cleanser further comprises: the skin penetration modifying liquid comprises one or two of weeping forsythia seeds and angelica, and volatile essential oil extracted by a steam distillation method. By selecting volatile essential oil extracted from weeping forsythia seeds and angelica as a matrix of the transdermal modification liquid, the skin-penetrating and transdermal absorption-promoting facial cleanser not only has good skin permeability and transdermal absorption promoting effects, but also can penetrate into the skin to perform good antibacterial effect on deep layers in the skin, and improves the acne-removing effect of the deep layer acne-removing facial cleanser.
In some embodiments of the invention, the preparation steps of the acne-removing gel solution are as follows: (1) taking traditional Chinese medicines, grinding and sieving, and collecting sieving particles; (2) Taking the sieved particles, using deionized water as a medium, carrying out water extraction treatment, and collecting water extract; (3) Adding the water extract into the polyvinyl alcohol solution, stirring, mixing and dispersing by ultrasonic to obtain the acne-removing gel solution. Through the simple scheme of water extraction treatment after grinding, acne removing substances can be effectively extracted, the preparation steps are simplified, and meanwhile, the acne removing effect of the deep acne removing type facial cleanser can be effectively improved.
Further, the traditional Chinese medicine comprises any one or a mixture of a plurality of astragalus, phellodendron and elm. The traditional Chinese medicine materials such as astragalus, phellodendron and garden burnet are selected to have the functions of clearing heat and drying dampness, purging fire and detoxifying, cooling blood and detoxifying, removing stasis and dredging channels, removing carbuncles and sores, detoxifying and healing sores and the like, so that the sensitivity of a skin structure to a acne removal product is reduced while the acne is effectively removed, and the acne removal effect on the skin is improved.
Optionally, the sieved granule has a particle size of 500 mesh. The particle size of the sieved particles is optimized, so that the extraction effect is improved, and the preparation cost is optimized.
In some embodiments of the invention, the transdermal modification fluid preparation steps are: (1) Mixing the materials, grinding, sieving, and collecting the ground particles; (2) Adding the ground particles into a volatile oil extractor, extracting, collecting a mixed solution, extracting the mixed solution with anhydrous diethyl ether, collecting an extract, drying the extract with anhydrous sodium sulfate, volatilizing and drying at room temperature, and collecting volatile essential oil; (3) And stirring and mixing the emulsion and the volatile essential oil, and performing ultrasonic dispersion to obtain the transdermal modified liquid. Through the synergistic effect of the emulsion and the volatile essential oil, the volatile essential oil forms a micromolecular volatile oil structure, so that the volatile oil permeation repair effect can be effectively improved, and meanwhile, the stability of the facial cleanser is improved through the emulsification effect of the emulsion when the facial cleanser is used.
In some embodiments of the invention, the emulsion comprises span-80, tween-80 and deionized water mixed in a mass ratio of 1:2:15.
As shown in fig. 1, the preparation method of the deep acne-removing facial cleanser according to the second aspect of the present invention specifically comprises the following preparation steps: s1, firstly stirring and mixing the transdermal modification liquid, the acne-removing gel liquid and the diatomite, placing the mixture in a homogenizer, homogenizing the mixture at room temperature, and collecting homogenized slurry; s2, stirring and mixing glycerol, propylene glycol and deionized water according to a formula, heating, preserving heat and dissolving, and collecting a dissolving solution; s3, adding potassium laurylphosphate, cocamidopropyl beet, dodecyl dimethyl betaine and N-lauroyl sarcosine sodium into the solution, stirring and mixing, standing and cooling, and collecting an intermediate mixed solution; and S4, adding the homogeneous slurry into the intermediate mixed solution, stirring and mixing, performing ultrasonic dispersion at room temperature, standing and defoaming, and filling and packaging to obtain the deep acne-removing facial cleanser. By mixing and homogenizing diatomite with the transdermal modification liquid and the acne-removing gel liquid, the diatomite effectively adsorbs and loads substances such as the transdermal modification liquid and the acne-removing gel liquid, so that the stability of the facial cleanser is improved, and meanwhile, the mixing effect of the facial cleanser can be effectively improved by the scheme of sectional mixing, so that the acne-removing effect of the deep acne-removing facial cleanser is improved.
In summary, the deep acne-removing cleanser provided by the embodiment of the invention adopts the traditional Chinese medicine extract as a main acne-removing material to extract and prepare gel, and firstly, the acne-removing treatment effect of the acne-removing product on the skin is improved through the coating property and the permeability of the gel, meanwhile, the traditional Chinese medicine acne-removing extract is adopted in the technical scheme, the metabolism of a human body can be effectively regulated through oral administration, the effect of treating acne can be achieved through the scheme of external coating, cleaning and the like, and the main pathogenic bacteria of acne can be inhibited through the scheme of external coating, cleaning and the like, and then, the volatile essential oil forms a small molecular volatile oil structure through the synergistic effect of the emulsion and the volatile essential oil, so that the volatile oil permeation repair effect can be effectively improved, and meanwhile, the stability performance of the cleanser is improved through the emulsification effect of the emulsion when the cleanser is used.
The following describes the preparation method of the deep acne-removing facial cleanser according to the embodiment of the invention in detail by combining specific examples.
Example 1
Grinding fructus forsythiae seeds in a grinding device, sieving with a 50-mesh sieve, collecting sieved particles, adding the sieved particles into a volatile oil extractor, extracting and collecting a mixed solution, extracting the mixed solution with anhydrous diethyl ether, collecting an extract, drying with anhydrous sodium sulfate, volatilizing and drying at room temperature, collecting volatile essential oil, mixing span-80, tween-80 and deionized water according to a mass ratio of 1:2:15, stirring to obtain a mixed emulsion, mixing the mixed emulsion and the volatile essential oil according to a mass ratio of 1:1, performing ultrasonic dispersion for 10min under 200W, and dispersing slurry to prepare a transdermal modified solution;
mixing and grinding astragalus, phellodendron and sanguisorba according to the mass ratio of 1:5:8, sieving with a 500-mesh sieve and collecting to obtain grinding particles, placing the grinding particles into deionized water, heating water for extraction and collecting an extracting solution according to the volume ratio of 1:1, stirring and mixing the extracting solution and a polyvinyl alcohol solution with the mass fraction of 8%, and performing ultrasonic dispersion for 10min at 200W to obtain an acne-removing gel solution;
stirring and mixing the transdermal modification liquid, the acne-removing gel liquid and 1000-mesh diatomite according to the mass ratio of 1:5:8, placing the mixture into a homogenizer, homogenizing the mixture at room temperature, and collecting homogenized slurry;
mixing glycerol, propylene glycol and deionized water according to a formula, carrying out heat preservation and dissolution at 85 ℃, collecting a dissolution solution, adding laurylphosphate potassium, cocamidopropyl beet, dodecyl dimethyl betaine and N-lauroyl sarcosine sodium into the dissolution solution, stirring and mixing, standing and cooling to 40 ℃, collecting an intermediate mixed solution, adding homogeneous slurry into the intermediate mixed solution according to a mass ratio of 1:8, stirring and mixing, carrying out ultrasonic dispersion at room temperature for 10min, standing and defoaming, and packaging to obtain the deep acne-removing type face cleaning milk.
Example 2
Grinding radix Angelicae sinensis in a grinding device, sieving with 50 mesh sieve, collecting sieved particles, adding the sieved particles into a volatile oil extractor, extracting and collecting mixed solution, extracting the mixed solution with anhydrous diethyl ether, collecting extract, drying with anhydrous sodium sulfate, volatilizing at room temperature, collecting volatile essential oil, mixing span-80, tween-80 and deionized water with a mass ratio of 1:2:15 to obtain mixed emulsion, mixing the mixed emulsion and volatile essential oil with stirring, and dispersing slurry under ultrasonic dispersion for 12min at 250W to obtain transdermal modified solution;
mixing and grinding astragalus, phellodendron and sanguisorba according to the mass ratio of 1:5:8, sieving with a 500-mesh sieve and collecting to obtain grinding particles, placing the grinding particles into deionized water, heating water for extraction and collecting an extracting solution according to the volume ratio of 1:1, stirring and mixing the extracting solution and a polyvinyl alcohol solution with the mass fraction of 8%, and performing ultrasonic dispersion at 250W for 12min to obtain an acne-removing gel solution;
stirring and mixing the transdermal modification liquid, the acne-removing gel liquid and 1000-mesh diatomite according to the mass ratio of 1:5:8, placing the mixture into a homogenizer, homogenizing the mixture at room temperature, and collecting homogenized slurry;
mixing glycerol, propylene glycol and deionized water according to a formula, carrying out heat preservation and dissolution at 87 ℃ and collecting a dissolution solution, adding laurinol potassium phosphate, cocamidopropyl beet, dodecyl dimethyl betaine and N-lauroyl sarcosine sodium into the dissolution solution, stirring and mixing, standing and cooling to 45 ℃, collecting an intermediate mixed solution, adding homogeneous slurry into the intermediate mixed solution according to a mass ratio of 1:8, stirring and mixing, carrying out ultrasonic dispersion at room temperature for 12min, standing and defoaming, and packaging to obtain the deep acne-removing type face cleaning milk.
Example 3
The preparation process of the deep acne-removing facial cleanser of the example 3 is free from adding transdermal modification liquid, and the other conditions and the component proportions are the same as those of the example 1.
Performance test
The performance test is carried out on the examples 1-3 respectively, and the physicochemical indexes and the acne removing effect of the deep acne removing type facial cleanser prepared by the specific test are analyzed.
Detection method/test method
Physical and chemical indexes: general detection
Acne removal effect: the deep acne-removing type facial cleanser prepared in the examples was subjected to human facial skin test, each example was configured for one man and one woman, the first grade is obvious red inflammatory acne and severe skin damage (+++), the second stage is with a small number of acnes, general skin lesions (++), the third stage is with a slight skin lesion (+), the fourth level is substantially no skin lesions (-), no significant differences in skin lesions of the 2 groups of patients prior to treatment, indicating no differences in acne and skin lesions of the 2 groups of patients, the scoring levels are shown in table 1 below, and the evaluation and statistical analysis of acne and skin lesions before and after 2 months of use are shown in tables 2 and 3 below:
table 1 scoring grade controls
Table 2 performance test table
Table 3 moisture retention test table
As can be seen from the performance tests in tables 2 and 3, the acne-removing effects of examples 1-2 are good, and the scheme adopted in the application can achieve good acne-removing effects, and meanwhile, the physicochemical properties of examples 1-2 are stable, so that good effects on product performance are achieved.
By comparing the performances of examples 1-2 and example 3, the anti-acne effect of the deep anti-acne facial cleanser in example 3 is reduced because the anti-acne facial cleanser is not added with the anti-acne agent in the preparation process, which also shows that the anti-acne agent adopted by the application has good skin permeability and transdermal absorption promoting effect and can permeate into the skin for treatment.
Comparative examples 1 to 3
In contrast to examples 1-2, comparative examples 1-3 used camphor tree leaf essential oil to prepare an emulsion instead of the transdermal modification liquid in the examples, and the other conditions and components were the same as those in examples 1-2.
Comparative examples 4 to 6
In comparison with examples 1-2, comparative examples 4-6 used erythromycin antimicrobial instead of acne-removing gel, and the other conditions and components were the same as those of examples 1-2.
Comparative examples 7 to 9
In contrast to examples 1-2, comparative examples 7-9 did not add diatomaceous earth, and the other conditions and components were identical to examples 1-2.
Performance test
Performance tests are carried out on comparative examples 1-9, and physicochemical indexes and acne removal effects of the deep acne removal type facial cleanser prepared by the specific tests are analyzed.
Detection method/test method
Physical and chemical indexes: general detection
Acne removal effect: the deep acne-removing type facial cleanser prepared in the examples was subjected to human facial skin test, each example was configured for one man and one woman, the first grade is obvious red inflammatory acne and severe skin damage (+++), the second stage is a composition with a small number of acnes, general skin lesions (++), the third level is slight skin lesions (+), the fourth level is substantially no skin lesions (-), there is no significant difference in skin lesions of the 2 groups of patients before treatment, which indicates that there is no difference in acne and skin lesions of the 2 groups of patients, and the evaluation and statistical analysis of acne and skin lesions before and after use for 2 months are shown in tables 4 and 5 below:
table 4 performance test table
Table 5 moisture retention test table
The performance of the comparative examples 1-3 and 1-2 is compared, and the transdermal modified liquid in the examples is not good due to the fact that the skin penetration performance of the emulsion prepared by the camphor tree leaf essential oil is poor in the comparative examples 1-3, so that the acne removing effect is not particularly remarkable, and the volatile essential oil extracted from weeping forsythia seeds and angelica sinensis is selected as a matrix of the transdermal modified liquid, so that the skin penetration and transdermal absorption promoting effect are good, the skin penetration can be formed, the deep layer in the skin can be well subjected to antibacterial effect, and the acne removing effect of the deep acne removing type facial cleanser is improved;
comparing the performance of comparative examples 4-6 with that of examples 1-2, and comparing comparative examples 4-6 with examples 1-2, wherein erythromycin antimicrobial is adopted to replace acne-removing gel, and although the acne-removing effect is remarkable, the skin state is poor, which indicates that the traditional Chinese medicine materials such as astragalus, phellodendron and garden burnet are selected to have the functions of clearing heat and drying dampness, purging fire and removing toxin, cooling blood and removing toxin, removing stasis and dredging channels, carbuncle and swelling and sore, detoxifying and healing sore and the like in the scheme of the application, and the skin structure is reduced in sensitivity of the acne-removing product while the acne is effectively removed, and the acne-removing effect on the skin is improved;
comparing the performances of the comparative examples 7-9 and the examples 1-2, wherein the comparative examples 7-9 are not added with diatomite, other conditions and components are consistent with the examples 1-2, and the stability of the facial cleanser is poor and the skin state after use is poor, which means that the diatomite, the transdermal modification liquid and the acne-removing gel liquid are mixed and homogenized, so that the diatomite effectively adsorbs and loads substances such as the transdermal modification liquid, the acne-removing gel liquid and the like, the stability of the facial cleanser is improved, and meanwhile, the mixing effect of the facial cleanser can be effectively improved by the scheme of sectionally mixing, so that the acne-removing effect of the deep acne-removing facial cleanser is improved.
In the description of the present specification, reference to the terms "one embodiment," "some embodiments," "illustrative embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that: many changes, modifications, substitutions and variations may be made to the embodiments without departing from the spirit and principles of the invention, the scope of which is defined by the claims and their equivalents.
Claims (4)
1. The deep acne-removing facial cleanser is characterized by comprising the following substances in parts by weight: 15-20 parts of diatomite, 3-5 parts of potassium laurylphosphate, 2-3 parts of glycerol, 10-15 parts of propylene glycol, 3-5 parts of cocamidopropyl beet, 3-5 parts of dodecyl dimethyl betaine, 1-2 parts of N-lauroyl sodium sarcosinate, 150-160 parts of deionized water, 15-20 parts of acne-removing gel liquid and transdermal modification liquid which is equal to the acne-removing gel liquid in weight parts;
the acne-removing gel liquid is prepared by mixing a traditional Chinese medicine extracting solution and a polyvinyl alcohol aqueous solution, and the preparation steps of the acne-removing gel liquid are as follows: (1) taking traditional Chinese medicines, grinding and sieving, and collecting sieving particles; the Chinese medicine comprises any one or a mixture of a plurality of astragalus, phellodendron and elm; (2) Taking the sieved particles, using deionized water as a medium, carrying out water extraction treatment, and collecting water extract; (3) Adding the water extract into a polyvinyl alcohol solution, stirring, mixing and performing ultrasonic dispersion to obtain an acne-removing gel solution;
the preparation method of the transdermal modification liquid comprises the following steps: (1) Placing the medicinal materials into a grinding device, grinding and sieving, and collecting grinding particles; the medicinal materials comprise one or two of weeping forsythia seeds and angelica sinensis; (2) Adding the ground particles into a volatile oil extractor, extracting, collecting a mixed solution, extracting the mixed solution with anhydrous diethyl ether, collecting an extract, drying the extract with anhydrous sodium sulfate, volatilizing and drying at room temperature, and collecting volatile essential oil; (3) And stirring and mixing the emulsion and the volatile essential oil, and performing ultrasonic dispersion to obtain the transdermal modified liquid.
2. The deep acne-removing facial cleanser of claim 1, wherein the sieved particles have a particle size of 500 mesh.
3. The deep acne-removing facial cleanser of claim 1, wherein the emulsion comprises span-80, tween-80 and deionized water mixed according to a mass ratio of 1:2:15.
4. A method for preparing the deep acne-removing type facial cleanser according to any one of claims 1 to 3, which is characterized by comprising the following specific preparation steps: s1, firstly stirring and mixing the transdermal modification liquid, the acne-removing gel liquid and the diatomite, placing the mixture in a homogenizer, homogenizing the mixture at room temperature, and collecting homogenized slurry; s2, stirring and mixing glycerol, propylene glycol and deionized water according to a formula, heating, preserving heat and dissolving, and collecting a dissolving solution; s3, adding potassium laurylphosphate, cocamidopropyl beet, dodecyl dimethyl betaine and N-lauroyl sarcosine sodium into the solution, stirring and mixing, standing and cooling, and collecting an intermediate mixed solution; and S4, adding the homogeneous slurry into the intermediate mixed solution, stirring and mixing, performing ultrasonic dispersion at room temperature, standing and defoaming, and filling and packaging to obtain the deep acne-removing facial cleanser.
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