CN107496708B - Traditional Chinese medicine mask for treating acne and preparation method thereof - Google Patents
Traditional Chinese medicine mask for treating acne and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine mask for treating acne, which is prepared from the following raw materials in parts by weight: 5-15 parts of scutellaria baicalensis, 5-15 parts of oldenlandia diffusa, 3-10 parts of wild chrysanthemum flower, 3-10 parts of dandelion, 1-6 parts of polygonum cuspidatum, 1-6 parts of fritillary bulb, 1-6 parts of tianlong, 15-30 parts of moutan bark and 15-30 parts of bletilla striata. The traditional Chinese medicine provided by the invention has heat-clearing and detoxifying components and anti-allergic components, all the components are mutually matched and comprehensively regulated, the traditional Chinese medicine has a remarkable curative effect on acne, can effectively treat papules and pustules and repair scars, can effectively prevent and treat facial skin allergy, and reduces skin irritation reaction.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine mask for treating acne and a preparation method thereof.
Background
Acne is the most common chronic inflammatory pilosebaceous disease in dermatology, is better for males and females in adolescence and is mostly secreted by sebaceous glands in a large quantity and is caused by reasons such as propionibacterium acnes proliferation, initial skin damage is conical papules with consistent hair follicles, inflammatory papules are formed by blackheads when the pimples are heavier, the state of an illness is lingering and repeated, scar and acne marks are easily formed after extrusion, the skin of a patient is damaged, the psychological burden of the patient is caused, and the life quality of the patient is directly influenced.
Acne is a multifactorial disease, and the pathogenesis of the acne is mainly related to factors such as sex hormone level, sebum secretion, propionibacterium acnes proliferation, keratosis of pilosebaceous ducts, inflammation and the like. The inflammation diminishing of the external medicine is the key point of treatment, the conventional external medicine has tretinoin, and the external tretinoin medicine can often cause skin irritation reactions, such as local erythema and desquamation, and tightness and burning sensation; benzoyl peroxide also has an irritant reaction to sensitive skin, so that the benzoyl peroxide needs to be tried from a low concentration and a small range, and the external antibiotic is easy to induce the drug resistance of propionibacterium acnes and cannot be used alone.
The traditional Chinese medicine treatment of the disease is mainly based on syndrome differentiation treatment, and simultaneously, a plurality of traditional Chinese medicine external treatment methods such as acupuncture, fire acupuncture, traditional Chinese medicine wet application, external application traditional Chinese medicine, inverse model method, liniment and the like are provided, although the treatments have certain progress, the treatment lacks the acknowledged reliable curative effect, the invaded people of the disease are teenagers, the requirements of the invaded people on the compliance of the medicine are high, the acceptance degree of the oral traditional Chinese medicine is not high, and the treatment with high pain of the acupuncture and the fire acupuncture is not easy to accept. The existing external traditional Chinese medicine is easy to cause skin irritation reaction and is inconvenient to use.
The invention content is as follows:
in order to solve the problems, the invention provides the traditional Chinese medicine mask for treating acne, which has the advantages of ideal curative effect, small toxic and side effects, difficult generation of anaphylactic reaction, convenient use and high compliance, and also provides the preparation method of the mask.
The traditional Chinese medicine mask provided by the invention is prepared from the following traditional Chinese medicinal materials in parts by weight:
5-15 parts of scutellaria baicalensis, 5-15 parts of oldenlandia diffusa, 3-10 parts of wild chrysanthemum flower, 3-10 parts of dandelion, 1-6 parts of polygonum cuspidatum, 1-6 parts of fritillary bulb, 1-6 parts of tianlong, 15-30 parts of moutan bark and 15-30 parts of bletilla striata.
Preferably, the traditional Chinese medicinal materials comprise the following components in parts by weight:
8-12 parts of scutellaria baicalensis, 8-12 parts of oldenlandia diffusa, 5-8 parts of wild chrysanthemum flower, 5-8 parts of dandelion, 4-6 parts of polygonum cuspidatum, 4-6 parts of fritillary bulb, 4-6 parts of tianlong, 20-25 parts of moutan bark and 20-25 parts of bletilla striata.
Optimally, the traditional Chinese medicinal materials comprise the following components in parts by weight: 10 parts of scutellaria baicalensis, 10 parts of oldenlandia diffusa, 8 parts of wild chrysanthemum flower, 7 parts of dandelion, 5 parts of polygonum cuspidatum, 5 parts of fritillary bulb, 5 parts of tianlong, 25 parts of moutan bark and 25 parts of bletilla striata.
The raw materials can be directly prepared into the mask after being crushed, and the medicinal materials can also be prepared into the mask after being extracted, so that the content of active ingredients can be higher, the content of impurities is lower, and the treatment effect is better when the medicinal materials are extracted.
The preparation method of the traditional Chinese medicine mask provided by the invention comprises the following steps:
1) weighing Scutellariae radix, flos Chrysanthemi Indici, herba Taraxaci, Bulbus Fritillariae Cirrhosae, and Gekko Swinhonis, decocting in water, and concentrating the extractive solution to obtain fluid extract;
2) weighing herba Hedyotidis Diffusae, rhizoma Polygoni Cuspidati, cortex moutan, and rhizoma Bletillae, percolating with 40-80% ethanol, recovering ethanol from extractive solution, and concentrating to obtain fluid extract;
3) mixing the fluid extracts obtained in steps 1) and 2), adding matrix, and making into facial mask.
On the basis of carrying out a large amount of researches on active ingredients for treating acne in medicinal materials, the applicant finally adopts a distributed extraction method for the raw medicinal materials, namely, part of the medicinal materials are subjected to water extraction, part of the medicinal materials are subjected to alcohol extraction, and the alcohol extraction adopts a leakage method.
Further preferably, the matrix consists of the following components in parts by weight:
25% of kaolin, 4% of talcum powder, 1% of titanium dioxide, 8% of glycerol, 10% of isopropyl palmitate, 5% of hydrogenated jojoba oil, 0.08% of essence and the balance of water.
The matrix has the effects of treating acne, moistening skin, and relieving, and can be used for promoting transdermal absorption of active ingredients in Chinese medicinal extract, and improving therapeutic effect.
Further preferably, the preparation method of the facial mask comprises the following steps: firstly, mixing kaolin, talcum powder and titanium dioxide uniformly with glycerol and part of water to prepare a powdery matrix; heating isopropyl palmitate, hydrogenated jojoba oil and the rest water, mixing, emulsifying, cooling to 30-40 deg.C, adding powdery matrix, essence and the mixed fluid extract, mixing, stirring, vacuum defoaming, standing for 24-48 hr, and coating on facial mask paper.
The invention has the beneficial effects that:
the traditional Chinese medicine provided by the invention has heat-clearing and detoxifying components and anti-allergic components, all the components are mutually matched, comprehensive conditioning is realized, the acne curative effect is obvious, the traditional Chinese medicine can effectively treat pimples and pustules and repair scars, can effectively prevent and treat facial skin allergy, reduce skin irritation reaction and cannot induce propionibacterium acnes to resist drugs.
The traditional Chinese medicine mask provided by the invention also has the effects of moistening and relieving the skin, is beneficial to the treatment of acne and the repair of scars, and the matrix provided by the invention is also beneficial to promoting the transdermal absorption of active ingredients of the medicine.
The traditional Chinese medicine mask provided by the invention has both a treatment effect and a beautifying effect, is convenient to use and carry, has high compliance, and is particularly suitable for young people.
Detailed Description
The present invention will be described in detail below with reference to specific examples.
Example 1
10g of scutellaria baicalensis, 10g of oldenlandia diffusa, 8g of wild chrysanthemum flower, 7g of dandelion, 5g of polygonum cuspidatum, 5g of fritillary bulb, 5g of tianlong, 25g of moutan bark and 25g of bletilla striata.
1) Weighing Scutellariae radix, flos Chrysanthemi Indici, herba Taraxaci, Bulbus Fritillariae Cirrhosae, and Gekko Swinhonis, adding 10 times of water, decocting for 2 times, each time for 2 hr, and concentrating the extractive solution to obtain fluid extract with relative density of 1.30 (measured under heat);
2) weighing herba Hedyotidis Diffusae, rhizoma Polygoni Cuspidati, cortex moutan, and rhizoma Bletillae, percolating with 60% (by weight) ethanol, recovering ethanol from the extractive solution, and concentrating to obtain fluid extract with relative density of 1.30 (measured under heat);
3) mixing the fluid extracts obtained in steps 1) and 2);
4) weighing the matrix raw materials in the following weight ratio:
25% of kaolin, 4% of talcum powder, 1% of titanium dioxide, 8% of glycerol, 10% of isopropyl palmitate, 5% of hydrogenated jojoba oil, 0.08% of essence and the balance of water.
Firstly, mixing kaolin, talcum powder and titanium dioxide uniformly with glycerol and part of water to prepare a powdery matrix; heating isopropyl palmitate, hydrogenated jojoba oil and the rest water, mixing, emulsifying, cooling to 40 deg.C, adding powder matrix and essence, stirring to obtain facial mask matrix, mixing the facial mask matrix and the mixed fluid extract at weight ratio of 15: 1, stirring, vacuum defoaming, standing for 48 hr, and coating on facial mask paper.
Example 2
15g of scutellaria baicalensis, 15g of oldenlandia diffusa, 10g of wild chrysanthemum flower, 10g of dandelion, 6g of polygonum cuspidatum, 1g of fritillary bulb, 1g of tianlong, 15g of moutan bark and 15g of bletilla striata.
1) Weighing Scutellariae radix, flos Chrysanthemi Indici, herba Taraxaci, Bulbus Fritillariae Cirrhosae, and Gekko Swinhonis, adding 6 times of water, decocting for 3 times, each for 1 hr, and concentrating the extractive solution to obtain fluid extract;
2) weighing herba Hedyotidis Diffusae, rhizoma Polygoni Cuspidati, cortex moutan, and rhizoma Bletillae, percolating with 40% ethanol, recovering ethanol from extractive solution, and concentrating to obtain fluid extract;
3) mixing the fluid extracts obtained in steps 1) and 2), adding matrix, and making into facial mask.
Example 3
5g of scutellaria baicalensis, 5g of oldenlandia diffusa, 3g of wild chrysanthemum flower, 3g of dandelion, 1g of polygonum cuspidatum, 6g of fritillary bulb, 6g of tianlong, 30g of moutan bark and 30g of bletilla striata.
1) Weighing radix Scutellariae, flos Chrysanthemi Indici, herba Taraxaci, Bulbus Fritillariae Cirrhosae, and Gekko Swinhonis, adding 15 times of water, decocting for 1 time, extracting for 3 hr, and concentrating the extractive solution to obtain fluid extract;
2) weighing herba Hedyotidis Diffusae, rhizoma Polygoni Cuspidati, cortex moutan, and rhizoma Bletillae, percolating with 80% ethanol, recovering ethanol from extractive solution, and concentrating to obtain fluid extract;
3) mixing the fluid extracts obtained in steps 1) and 2), adding matrix, and making into facial mask.
EXAMPLE 4 clinical trial
Western diagnostic criteria: meets the diagnosis standard of acne in clinical dermatology.
The traditional Chinese medicine diagnosis standard is as follows: according to the diagnosis standards of the syndrome of wind-heat in lung channel and the dampness-heat in liver and gallbladder specified in the terms of treatment by dialectical methods of traditional Chinese medicine, the medicine conforms to the judgment standard of the type of wind-heat in lung channel and dampness-heat in liver and gallbladder of acne in the standard of curative effect of diagnosis of traditional Chinese medicine.
Inclusion and exclusion criteria for study cases
Inclusion case criteria: the acne diagnosis standard is met, and the traditional Chinese medicine acne diagnosis standard of lung channel wind heat and liver and gallbladder damp heat is met.
Exclusion criteria for cases: 1. the patient takes the isotretinoin medicine within 4 weeks, and takes the antibiotic medicine within 4 weeks; 2. the patient is externally applied with antibiotic ointment within 4 weeks; 3. patients who fail to adhere to topical medications; 4. pregnant and lactating women; 5. patients who cannot be matched with clinical trials; 6. patients who continuously feel facial discomfort during the administration process.
Research method
141 outpatient patients in the outpatient department of 2015 1-2017 2 are selected and randomly divided into a treatment group, a blank control group and a positive control group, wherein the number of the treatment group is 48, the number of the blank control group is 46, and the number of the positive control group is 47.
Wherein: 59 cases with acne as the main, a few papules and pustules and less than 30 total lesions (mild grade 1); there were comedones, moderate numbers of papules and pustules, with a total lesion count of between 31-50 (moderate grade 2) 47 cases; there were a large number of papules and pustules, with a total lesion count of 51-100 and fewer than 3 nodules (moderate grade 3) 35.
20 male patients and 28 female patients are treated, wherein the age is 14-39 years, the average age (22.98 +/-8.16) years, the course of disease is 3 months-11.7 years, and the average course of disease (4.42 +/-2.24) years; 18 male and 28 female in the control group, wherein the age is 14-40 years, the average age (23.46 +/-7.36) years, the course of disease is 1-10.9 years, and the average course of disease (4.35 +/-2.53) years; the positive control group comprises 17 men and 30 women, the age is 15-41 years, the average age (24.47 +/-10.88) years, the course is 8 months-11.7 years, and the average course (5.33 +/-3.16) years. The patients in the treatment group and the blank control group have no significant difference (P >0.05) in terms of sex, age and disease course after statistical treatment and are comparable; the treated group and the positive control group have no significant difference (P >0.05) in terms of sex, age and disease course after statistical treatment and are comparable.
The treatment group is externally applied with the facial mask of the invention once a day, and 10 days are a treatment course; the blank control group is externally applied with normal saline once a day, and 10 days are a treatment course; the positive control group was topically administered to the patient with bamisal (benzoyl peroxide gel) once daily. After one treatment period, the treatment group and the blank control group, the control group and the positive control group are respectively subjected to once curative effect evaluation.
The number of the acne, the pimple and the pustule of the patient are respectively added, the number is statistically analyzed before the treatment, and the statistical analysis is carried out on the difference value between before treatment and after treatment.
The administration time is 10 days per cycle.
Observing indexes, adding the number of acnes, papules and pustules before treatment, comparing the difference value before treatment and after treatment, and analyzing the curative effect by the percentage of the total integral before treatment to the total integral after treatment/the total integral before treatment.
And (3) healing: (percentage of pre-treatment total score-post-treatment total score)/pre-treatment total score > 75%
The effect is shown: (pre-treatment total score-post-treatment total score)/pre-treatment total score percentage is 50% -75%
The method has the following advantages: (pre-treatment total score-post-treatment total score)/percentage of pre-treatment total score 25% -50%
And (4) invalidation: (pre-treatment total score-post-treatment total score)/percentage of pre-treatment total score < 25%
The research results are as follows:
adverse reactions: the patients occasionally have skin allergy, 1 case appears in the treatment group, the transient anaphylactic reaction is relieved after ice compress; the positive control group suffers from facial desquamation in 5 cases, and stops taking the medicine, but the follow-up visit can be followed, no discomfort exists, only the skin is slightly dry, and the skin is relieved after the angelica cream is externally used.
TABLE 1 comparison of the therapeutic efficacy of the treatment groups with that of the positive control group
| Group of | Recovery method | Show effect | Is effective | Invalidation | Total effective rate (%) |
| Treatment group | 13 | 15 | 8 | 12 | 75％ |
| Positive control group | 11 | 17 | 10 | 9 | 80.8％ |
Compared with the positive control group, the p of the treatment group is more than 0.05, and the difference of the effective rates of the two groups has no statistical significance.
TABLE 2 comparison of the therapeutic efficacy of the treatment groups with that of the placebo group
| Group of | Recovery method | Show effect | Is effective | Invalidation | Total effective rate (%) |
| Treatment group | 13 | 15 | 8 | 12 | 75％ |
| Blank control group | 2 | 6 | 9 | 29 | 36.9％ |
Compared with the positive control group, the p of the treatment group is less than 0.05, and the difference of the effective rates of the two groups has statistical significance.
Claims (4)
1. The application of a traditional Chinese medicine in preparing a mask for treating acne caused by wind heat in lung channels and dampness-heat in liver and gallbladder is characterized in that the traditional Chinese medicine is prepared from the following traditional Chinese medicinal materials in parts by weight:
8-12 parts of scutellaria baicalensis, 8-12 parts of oldenlandia diffusa, 5-8 parts of wild chrysanthemum flower, 5-8 parts of dandelion, 4-6 parts of polygonum cuspidatum, 4-6 parts of thunberg fritillary bulb, 4-6 parts of tianlong, 20-25 parts of moutan bark, 20-25 parts of bletilla striata
The preparation method comprises the following steps:
1) weighing Scutellariae radix, flos Chrysanthemi Indici, herba Taraxaci, Bulbus Fritillariae Cirrhosae, and Gekko Swinhonis, decocting in water, and concentrating the extractive solution to obtain fluid extract;
2) weighing herba Hedyotidis Diffusae, rhizoma Polygoni Cuspidati, cortex moutan, and rhizoma Bletillae, percolating with 40-80% ethanol, recovering ethanol from extractive solution, and concentrating to obtain fluid extract;
3) mixing the fluid extracts obtained in steps 1) and 2), adding matrix, and making into facial mask.
2. The application of claim 1, wherein the traditional Chinese medicine is prepared from the following traditional Chinese medicinal materials in parts by weight:
10 parts of scutellaria baicalensis, 10 parts of oldenlandia diffusa, 8 parts of wild chrysanthemum flower, 7 parts of dandelion, 5 parts of polygonum cuspidatum, 5 parts of fritillary bulb, 5 parts of tianlong, 25 parts of moutan bark and 25 parts of bletilla striata.
3. The use according to claim 1, characterized in that the matrix consists of the following components in parts by weight:
25% of kaolin, 4% of talcum powder, 1% of titanium dioxide, 8% of glycerol, 10% of isopropyl palmitate, 5% of hydrogenated jojoba oil, 0.08% of essence and the balance of water.
4. The use according to claim 3, wherein the mask is prepared by a method comprising: firstly, mixing kaolin, talcum powder and titanium dioxide uniformly with glycerol and part of water to prepare a powdery matrix; heating isopropyl palmitate, hydrogenated jojoba oil and the rest water, mixing, emulsifying, cooling to 30-50 deg.C, adding powdery matrix, essence and the mixed fluid extract, mixing, stirring, vacuum defoaming, standing for 24-48 hr, and coating on facial mask paper.
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| CN106177273A (en) * | 2014-10-08 | 2016-12-07 | 丁雪强 | A kind of face mask of traditional Chinese medicine treating acne |
| CN104622740A (en) * | 2015-01-14 | 2015-05-20 | 武汉爱民制药有限公司 | Application of semen aesculi extract in preparation of pharmaceutical cosmetic |
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