CN112204073A - 聚合物材料以及眼内透镜 - Google Patents
聚合物材料以及眼内透镜 Download PDFInfo
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- CN112204073A CN112204073A CN201980036577.9A CN201980036577A CN112204073A CN 112204073 A CN112204073 A CN 112204073A CN 201980036577 A CN201980036577 A CN 201980036577A CN 112204073 A CN112204073 A CN 112204073A
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- Prior art keywords
- intraocular lens
- meth
- monomer
- acrylate
- macromonomer
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- 239000002861 polymer material Substances 0.000 title claims abstract description 35
- 239000000178 monomer Substances 0.000 claims abstract description 153
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims abstract description 94
- 239000000203 mixture Substances 0.000 claims abstract description 54
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 claims abstract description 19
- 125000003118 aryl group Chemical group 0.000 claims abstract description 17
- 125000001424 substituent group Chemical group 0.000 claims abstract description 12
- 230000000379 polymerizing effect Effects 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims description 133
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 4
- 230000002087 whitening effect Effects 0.000 abstract description 38
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- 125000003827 glycol group Chemical group 0.000 description 34
- -1 methacryloyl group Chemical group 0.000 description 32
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- IQGIEMYBDGDBMR-UHFFFAOYSA-N (3-methyl-5-prop-2-enoyloxypentyl) prop-2-enoate Chemical compound C=CC(=O)OCCC(C)CCOC(=O)C=C IQGIEMYBDGDBMR-UHFFFAOYSA-N 0.000 description 1
- IMNBHNRXUAJVQE-UHFFFAOYSA-N (4-benzoyl-3-hydroxyphenyl) 2-methylprop-2-enoate Chemical compound OC1=CC(OC(=O)C(=C)C)=CC=C1C(=O)C1=CC=CC=C1 IMNBHNRXUAJVQE-UHFFFAOYSA-N 0.000 description 1
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- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 description 1
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- QDAWPRZFHMNWIR-UHFFFAOYSA-N 2-[2-(3-tert-butyl-2-hydroxy-5-methylphenyl)benzotriazol-5-yl]ethyl 2-methylprop-2-enoate Chemical compound N1=C2C=C(CCOC(=O)C(=C)C)C=CC2=NN1C1=CC(C)=CC(C(C)(C)C)=C1O QDAWPRZFHMNWIR-UHFFFAOYSA-N 0.000 description 1
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- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 239000001060 yellow colorant Substances 0.000 description 1
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- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
- C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
- C08F20/10—Esters
- C08F20/26—Esters containing oxygen in addition to the carboxy oxygen
- C08F20/30—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
- C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
- C08F20/10—Esters
- C08F20/12—Esters of monohydric alcohols or phenols
- C08F20/14—Methyl esters, e.g. methyl (meth)acrylate
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
- C08F220/30—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
- C08F220/30—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety
- C08F220/301—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety and one oxygen in the alcohol moiety
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
- C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
- C08F290/06—Polymers provided for in subclass C08G
- C08F290/062—Polyethers
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L33/04—Homopolymers or copolymers of esters
- C08L33/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/16965—Lens includes ultraviolet absorber
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
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- Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Abstract
Description
PCT国内申请,说明书已公开。
Claims (13)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018-106165 | 2018-06-01 | ||
JP2018106165A JP6784720B2 (ja) | 2018-06-01 | 2018-06-01 | ポリマー材料および眼内レンズ |
PCT/CN2019/087749 WO2019228224A1 (zh) | 2018-06-01 | 2019-05-21 | 聚合物材料以及眼内透镜 |
Publications (2)
Publication Number | Publication Date |
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CN112204073A true CN112204073A (zh) | 2021-01-08 |
CN112204073B CN112204073B (zh) | 2023-05-09 |
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CN201980036577.9A Active CN112204073B (zh) | 2018-06-01 | 2019-05-21 | 聚合物材料以及眼内透镜 |
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US (1) | US20210292447A1 (zh) |
EP (1) | EP3805290A4 (zh) |
JP (1) | JP6784720B2 (zh) |
CN (1) | CN112204073B (zh) |
TW (1) | TWI776064B (zh) |
WO (1) | WO2019228224A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113549174A (zh) * | 2021-04-06 | 2021-10-26 | 富螺(上海)医疗器械有限公司 | 聚合物、聚合物的制造方法以及人工晶状体 |
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CN102007452A (zh) * | 2008-04-14 | 2011-04-06 | 旭化成电子材料株式会社 | 感光性树脂组合物及其层压体 |
CN102786640A (zh) * | 2011-05-17 | 2012-11-21 | 日本化药株式会社 | 光学透镜片用能量射线固化型树脂组合物、其固化物及光学透镜片 |
CN104136050A (zh) * | 2012-02-15 | 2014-11-05 | 诺华股份有限公司 | 含多臂peg大分子单体的眼科和耳鼻喉科装置材料 |
JP2015025063A (ja) * | 2013-07-26 | 2015-02-05 | 株式会社トクヤマ | フォトクロミック硬化性組成物、該組成物を含むコーティング剤、及びフォトクロミック積層体 |
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DE69122471T2 (de) | 1990-11-07 | 1997-02-06 | Nestle Sa | Polymere und ihre Verwendung für opthalmische Linsen |
US5603774A (en) | 1993-09-27 | 1997-02-18 | Alcon Laboratories, Inc. | Method for reducing tackiness of soft acrylic polymers |
US5470932A (en) | 1993-10-18 | 1995-11-28 | Alcon Laboratories, Inc. | Polymerizable yellow dyes and their use in opthalmic lenses |
JP2967093B2 (ja) | 1995-02-23 | 1999-10-25 | ホーヤ株式会社 | 軟性眼内レンズ |
WO1996040303A1 (en) * | 1995-06-07 | 1996-12-19 | Alcon Laboratories, Inc. | Improved high refractive index ophthalmic lens materials |
SE9600006D0 (sv) * | 1996-01-02 | 1996-01-02 | Pharmacia Ab | Foldable intraocular lens materials |
JPH10195324A (ja) | 1997-01-16 | 1998-07-28 | Hoya Corp | 反応性黄色染料およびそれを含む眼用レンズ |
ES2326706T3 (es) * | 1998-04-15 | 2009-10-16 | Alcon, Inc. | Materiales para dispositivos oftalmicos de alto indice de refraccion. |
US6353069B1 (en) | 1998-04-15 | 2002-03-05 | Alcon Manufacturing, Ltd. | High refractive index ophthalmic device materials |
JP3449406B2 (ja) | 1999-04-07 | 2003-09-22 | Hoyaヘルスケア株式会社 | 新規ピラゾロン化合物およびそれを用いた眼用プラスチックレンズ |
JP4896036B2 (ja) | 2004-11-22 | 2012-03-14 | アボット・メディカル・オプティクス・インコーポレイテッド | 共重合性アゾ化合物およびそれを含有する物品 |
CA2588528C (en) | 2004-11-22 | 2013-08-06 | Jason Clay Pearson | Copolymerizable methine and anthraquinone compounds and articles containing them |
TWI487690B (zh) | 2009-07-06 | 2015-06-11 | Alcon Inc | 用於眼用鏡片材料之可見光吸收劑 |
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CN103705973B (zh) * | 2013-11-19 | 2015-11-18 | 无锡蕾明视康科技有限公司 | 光致可增色的黄色眼内透镜装置及其制备方法 |
-
2018
- 2018-06-01 JP JP2018106165A patent/JP6784720B2/ja active Active
-
2019
- 2019-05-21 WO PCT/CN2019/087749 patent/WO2019228224A1/zh unknown
- 2019-05-21 EP EP19811260.9A patent/EP3805290A4/en active Pending
- 2019-05-21 CN CN201980036577.9A patent/CN112204073B/zh active Active
- 2019-05-21 US US15/734,039 patent/US20210292447A1/en active Pending
- 2019-05-31 TW TW108118855A patent/TWI776064B/zh active
Patent Citations (4)
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CN102007452A (zh) * | 2008-04-14 | 2011-04-06 | 旭化成电子材料株式会社 | 感光性树脂组合物及其层压体 |
CN102786640A (zh) * | 2011-05-17 | 2012-11-21 | 日本化药株式会社 | 光学透镜片用能量射线固化型树脂组合物、其固化物及光学透镜片 |
CN104136050A (zh) * | 2012-02-15 | 2014-11-05 | 诺华股份有限公司 | 含多臂peg大分子单体的眼科和耳鼻喉科装置材料 |
JP2015025063A (ja) * | 2013-07-26 | 2015-02-05 | 株式会社トクヤマ | フォトクロミック硬化性組成物、該組成物を含むコーティング剤、及びフォトクロミック積層体 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113549174A (zh) * | 2021-04-06 | 2021-10-26 | 富螺(上海)医疗器械有限公司 | 聚合物、聚合物的制造方法以及人工晶状体 |
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Publication number | Publication date |
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JP6784720B2 (ja) | 2020-11-11 |
TW202002917A (zh) | 2020-01-16 |
JP2019210345A (ja) | 2019-12-12 |
TWI776064B (zh) | 2022-09-01 |
US20210292447A1 (en) | 2021-09-23 |
WO2019228224A1 (zh) | 2019-12-05 |
EP3805290A4 (en) | 2022-03-16 |
CN112204073B (zh) | 2023-05-09 |
EP3805290A1 (en) | 2021-04-14 |
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