CN112190650A

CN112190650A - Traditional Chinese medicine composition and medicament for treating skin wounds

Info

Publication number: CN112190650A
Application number: CN202011355699.5A
Authority: CN
Inventors: 董亚利; 雷紫涵
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-11-26
Filing date: 2020-11-26
Publication date: 2021-01-08

Abstract

A Chinese medicinal composition and medicament for the treatment of skin wound, relate to the technical field of the medicament, it includes Borneo camphor, cinnabar, borax, gypsum fibrosum preparatum, frankincense, Myrrha, phellodendron, etc., mix according to the specific proportion to get final product, the proportion is scientific and reasonable between the medicaments, can give full play to its synergistic interaction, have better curative effect to various skin wounds, and have with instant effect, relieve patient's pain, innoxic side effect, characteristic such as not leaving scar. Meanwhile, the traditional Chinese medicine composition has a larger expansion space, according to the type difference of skin wounds, musk, goldthread root, bezoar, dragon's blood, scutellaria baicalensis, catechu and other medicines can be selectively added for matching, the curative effect of the traditional Chinese medicine composition on specific wound types is improved, and the traditional Chinese medicine composition has a better practical value.

Description

Traditional Chinese medicine composition and medicament for treating skin wounds

Technical Field

The invention relates to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition and a medicament for treating skin wounds.

Background

The skin covers the entire body surface and is one of the largest organs of the human body, accounting for about 16% of body weight. Meanwhile, the skin is the first barrier for resisting external bacteria, viruses and the like from invading the human body, once the skin has large wound, the external resisting effect is lost, the wound is infected and inflamed, other complications are caused, and even the life is threatened under severe conditions.

In general, in the case of extensive trauma to the skin, serious infections occur, which are difficult to self-heal by the patient alone, and the patient suffers from a great deal of pain. At this time, external medicines are needed to assist wound healing, and the existing medicines for treating skin wounds have the problems of slow effect, poor pain relieving effect, side effect, poor healing effect on large-area and serious wounds and the like.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition and a medicament for treating skin wounds, which have scientific and reasonable proportion, easily obtained raw materials, better healing effect on various types of skin wounds, quick response, no toxic or side effect and better practical value.

The embodiment of the invention is realized by the following steps:

a traditional Chinese medicine composition for treating skin wounds comprises the following components in parts by weight:

10-30 parts of borneol, 10-30 parts of cinnabar, 20-60 parts of borax, 20-60 parts of calcined gypsum, 3-15 parts of frankincense, 4-20 parts of myrrh, 5-30 parts of phellodendron, 0-5 parts of musk, 0-5 parts of saffron crocus, 0-15 parts of coptis chinensis, 0-5 parts of bezoar, 0-15 parts of dragon's blood, 0-30 parts of scutellaria baicalensis and 0-15 parts of catechu.

A medicament for treating skin wounds comprises the traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials.

The embodiment of the invention has the beneficial effects that:

the embodiment of the invention provides a traditional Chinese medicine composition and a medicament for treating skin wounds, which are prepared by mixing main medicines such as borneol, cinnabar, borax, calcined gypsum, frankincense, myrrh and golden cypress according to a specific proportion, the medicines are scientific and reasonable in proportion, the synergistic effect can be fully exerted, the traditional Chinese medicine composition has a better healing effect on various types of skin wounds, and has the characteristics of quick pain relieving, quick inflammation diminishing, quick granulation promoting, no toxic or side effect, no scar and the like. Meanwhile, the traditional Chinese medicine composition has a larger expansion space, according to the type difference of skin wounds, musk, goldthread root, bezoar, dragon's blood, scutellaria baicalensis, catechu and other medicines can be selectively added for matching, the curative effect of the traditional Chinese medicine composition on specific wound types is improved, and the traditional Chinese medicine composition has a better practical value.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.

FIG. 1 is a schematic illustration of a wound prior to application of the drug to observation group A17 provided in accordance with an experimental example of the present invention;

FIG. 2 is a schematic representation of the observation of healing after wound healing in group A17 after drug administration provided by the experimental examples of the present invention;

FIG. 3 is a diagram of the treatment process provided in case 1 of the present invention;

FIG. 4 is a diagram of the treatment process provided in example 3 of the present invention;

FIG. 5 is a graph of the treatment process provided in case 4 of the present invention;

FIG. 6 is a graph of the treatment process provided in example 5 of the present invention;

fig. 7 is a diagram of the treatment process provided in case 6 of the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

The following describes a Chinese medicinal composition and a medicament for treating skin wounds in an embodiment of the present invention.

Wherein Borneolum is crystal prepared by distilling and cooling trunk of Borneolum of evergreen arbor of Dipterocarpaceae, and has cold nature, pungent and bitter taste, has effects of inducing resuscitation, refreshing mind, clearing heat and relieving pain, and can be used for treating coma, pyocutaneous disease, sore throat, aphtha, etc.

Cinnabar is an ore of cinnabar in a hexagonal system and mainly contains mercuric sulfide. Is cold in nature and sweet in taste, has the effects of relieving mental uneasiness, clearing away heat and toxic materials, and is commonly used for treating uneasiness, palpitation, insomnia, sore and ulcer, swelling and pain in throat, aphtha of the mouth and tongue, etc.

The main component of borax is sodium tetraborate. Cool in nature, sweet and salty in taste, has the effects of clearing heat and dissolving phlegm, detoxifying and preventing corrosion, removing necrotic tissue and promoting granulation, and is commonly used for treating phlegm-heat cough, throat impediment, thrush, dysphagia accumulation, bone sticking throat, nebula, pterygium, pudendum ulcer and the like.

Calcined gypsum is a processed product of gypsum, is cold in nature, sweet, pungent and astringent in flavor, has the effects of astringing dampness, promoting granulation, healing sores and stopping bleeding, and is commonly used for treating unhealed ulcer, eczema and pruritus, scald caused by water and fire, traumatic bleeding and the like.

The Olibanum is resin exuded from bark of Boswellia carterii of Burseraceae and its congeneric plant. Warm in nature, pungent and bitter in flavor, has the effects of promoting blood circulation, relieving pain, detumescence and promoting granulation, and is mainly used for treating dysmenorrhea amenorrhea, epigastric pain, rheumatalgia, traumatic injury pain, carbuncle swelling and sore ulcer.

The Myrrha is oleoresin exuded from stem and bark of Commiphora myrrha of Burseraceae or other plants of the same genus. Neutral in nature and bitter in taste, has the effects of promoting blood circulation, relieving pain, detumescence and promoting granulation, and is mainly used for treating amenorrhea and abdominal pain, epigastric pain, traumatic injury and pain, carbuncle swelling and sore and ulcer.

Cortex Phellodendri is bark of cortex Phellodendri (bark of phellodendron amurense Rupr. et Maxim. of Rutaceae) or cortex Phellodendri (bark of phellodendron chinense Miller) without cortex Phellodendri. Is cold in nature and bitter in taste, has the effects of clearing heat and eliminating dampness, purging fire and removing toxicity, and relieving deficiency heat, and is mainly used for treating damp-heat diarrhea, dysentery, jaundice, leukorrhagia, pyocutaneous disease due to heat toxin, eczema, fever due to yin deficiency, etc.

The Moschus is dry secretion of mature sachet of deer family animal such as forest musk deer, horse or original musk deer. Warm in nature and pungent in flavor, has effects of inducing resuscitation and enlivening spleen, promoting blood circulation and removing blood stasis, relieving pain, and inducing parturition, and is mainly used for treating coma, heart and abdomen pain, traumatic injury, amenorrhea mass, skin ulcer, sore throat, dystocia, stillborn fetus, etc.

Stigma croci Sativi is the upper part and stigma of stigma croci Sativi of Iridaceae. Has mild nature and sweet taste, has the effects of promoting blood circulation, removing blood stasis and resolving stagnation, and is mainly used for treating anxiety, chest distress, hematemesis, typhoid fever, absentmindedness, amenorrhea, postpartum blood stasis, abdominal pain, traumatic injury, swelling and pain and the like.

The Coptidis rhizoma is rhizome of Coptis chinensis Franch or Coptis Teeta wall of Ranunculaceae. Cold in nature and bitter in taste. Has effects of clearing heat, eliminating dampness, clearing pathogenic fire, and removing toxic substance, and can be used for treating gastrointestinal damp-heat, emesis, dysentery, hyperpyrexia, coma, vexation, insomnia, hematemesis, epistaxis, pyocutaneous disease, suppurative otitis, eczema, stomach fire, and toothache.

Calculus bovis is gallbladder calculus of cattle of Bovidae, has cold nature and bitter taste, and has effects of clearing heat and detoxicating, calming endogenous wind and relieving spasm, eliminating phlegm and inducing resuscitation. It is mainly used for treating convulsion due to excessive heat, coma, and pyocutaneous disease due to heat toxin.

Sanguis Draxonis is resin exuded from fruit of daemonorops draco of Palmae. Neutral in nature, sweet and salty in taste, and has the effects of promoting blood circulation, relieving pain, removing blood stasis, stopping bleeding, healing sore and promoting granulation. It is mainly used for treating traumatic injury, heart and abdominal pain, traumatic hemorrhage, and unhealed skin and external diseases.

Scutellariae radix is root of Scutellaria baicalensis Georgi of Labiatae family. Is cold in nature and bitter in taste, and has the effects of clearing heat and drying dampness, purging fire and removing toxicity, stopping bleeding and preventing miscarriage. It is mainly used for treating damp-warm syndrome, jaundice, dysentery, stranguria caused by heat, hyperpyrexia, polydipsia, cough due to lung heat, hematemesis, epistaxis, carbuncle, suppurative sore, threatened abortion, etc.

Catechu is dry extract prepared by decocting heartwood or peeled branch of Catechu of Leguminosae. Is cool in nature, bitter and astringent in taste, has effects of clearing heat, eliminating phlegm, promoting fluid production, quenching thirst, stopping bleeding, relieving pain, eliminating dampness and healing sore, and is mainly used for treating phlegm heat cough, dysphoria with smothery sensation, diabetes, pharyngitis, ulcerative gingivitis, hemoptysis, hematemesis, epistaxis, hematuria, hematochezia, bloody flux, metrorrhagia, traumatic hemorrhage, hemorrhoid swelling and pain, unhealed pyocutaneous disease, eczema, and leukorrhagia.

The medicinal materials comprise a plurality of Chinese medicinal materials with the effects of stopping bleeding, removing necrotic tissue, promoting granulation and relieving pain, and the Chinese medicinal materials are carefully matched by an inventor and combined according to a specific proportion, so that the medicinal properties of the components can be fully exerted, and a synergistic effect is achieved, thereby achieving the effects of good curative effect, quick response, small pain and no toxic or side effect on skin wounds. In addition, the traditional Chinese medicine composition has better expansibility. Wherein, borneol, cinnabar, borax, calcined gypsum, frankincense, myrrh and phellodendron are fixed components, musk, saffron, goldthread root, bezoar, dragon's blood, scutellaria and catechu are selected components, and different selected components can be added on the basis of the fixed components according to different skin wound types to play a targeted role and achieve a more optimized treatment effect.

For example, the embodiment of the invention provides a traditional Chinese medicine composition for treating skin wounds, which comprises the following components in parts by weight:

10-30 parts of borneol, 10-30 parts of cinnabar, 20-60 parts of borax, 20-60 parts of calcined gypsum, 3-9 parts of frankincense, 4-12 parts of myrrh, 10-30 parts of golden cypress, 1-3 parts of musk, 1-3 parts of saffron crocus and 5-15 parts of coptis chinensis.

The formula selects musk, saffron and coptis chinensis in selected components on the basis of fixing the components, has better effects on hemostasis, analgesia, inflammation diminishing and infection resistance relatively, and has better treatment effect on the repair of some fresh wounds and small-area wounds, such as surgical wounds, wounds after cosmetic operations, cervical erosion and cervical hypertrophy.

For another example, the embodiment of the present invention provides a traditional Chinese medicine composition for treating skin wounds, which comprises the following components, by weight:

10-30 parts of borneol, 10-30 parts of cinnabar, 20-60 parts of borax, 20-60 parts of calcined gypsum, 3-9 parts of frankincense, 4-12 parts of myrrh, 6-12 parts of golden cypress, 1-3 parts of bezoar, 5-15 parts of dragon's blood and 5-15 parts of scutellaria baicalensis.

The formula selects the bezoar, the dragon's blood and the baical skullcap root in selected components on the basis of fixed components, has better effects on clearing heat, purging intense heat, detoxifying and easing pain relatively, and has better treatment effect on the repair of certain burns and scalds.

For another example, the embodiment of the present invention provides a traditional Chinese medicine composition for treating skin wounds, which includes, by weight:

10-30 parts of borneol, 10-30 parts of cinnabar, 20-60 parts of borax, 20-60 parts of calcined gypsum, 4-12 parts of frankincense, 5-15 parts of myrrh, 6-18 parts of golden cypress, 1-3 parts of musk, 5-15 parts of goldthread root, 1-3 parts of bezoar, 3-9 parts of dragon's blood, 10-30 parts of scutellaria baicalensis and 5-15 parts of catechu.

The formula is characterized in that on the basis of fixed components, musk, goldthread root, bezoar, dragon's blood, scutellaria and catechu are selected from selected components, and the formula is relatively complete, the medicine property is stronger, and the formula has better performance in the aspects of hemostasis, detumescence, analgesia, decay removal, vital function generation and the like, and is particularly suitable for treating diseases which are seriously worsened by long-term accumulation, such as diabetic feet and the like.

10-30 parts of borneol, 10-30 parts of cinnabar, 20-40 parts of borax, 40-60 parts of calcined gypsum, 4-8 parts of frankincense, 10-15 parts of myrrh, 12-18 parts of golden cypress, 3-5 parts of musk, 10-15 parts of goldthread root, 3-5 parts of bezoar, 10-15 parts of dragon's blood, 5-10 parts of scutellaria baicalensis and 5-10 parts of catechu.

The formula is based on the formula suitable for treating some diseases seriously deteriorated by long-term accumulation, and is particularly fine-tuned for the disease of bedsore, and the treatment effect of the bedsore is obviously enhanced.

It should be noted that the musk and bezoar used in the present application are artificial musk and artificial bezoar, and there is no behavior prohibited by law.

In addition, the application also provides a medicament for treating skin wounds, which comprises the traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials. The auxiliary materials can be solvents, propellants, solubilizers, solubilizing agents, emulsifiers, colorants, adhesives, disintegrants, fillers, lubricants, wetting agents, osmotic pressure regulators, stabilizers, glidants, flavoring agents, preservatives, suspending agents, coating materials, fragrances, anti-adhesives, integration agents, permeation promoters, pH regulators, buffers, plasticizers, surfactants, foaming agents, antifoaming agents, thickeners, encapsulation agents, humectants, absorbents, diluents, flocculants and deflocculants, filter aids, release retardants, and the like, depending on the dosage form of the medicament.

Furthermore, the medicament is mainly used as an external medicament, and the medicament is a paste. The preparation method comprises weighing the raw materials at a certain proportion, grinding into fine powder, and mixing with matrix such as vaseline and beeswax. Or pulverizing the raw materials, extracting with organic solvent, filtering to remove residue, concentrating, removing solvent, and mixing with matrix. The paste can be directly applied to affected part. And the ointment medicament can not cause secondary injury when changing the dressing, has no pain in the dressing changing process, and is beneficial to the recovery of the wound surface.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The embodiment provides a traditional Chinese medicine composition for treating skin wounds, which comprises the following components in parts by weight:

30 parts of borneol, 10 parts of cinnabar, 60 parts of borax, 20 parts of calcined gypsum, 3 parts of frankincense, 12 parts of myrrh, 10 parts of golden cypress, 1 part of musk, 2 parts of saffron and 15 parts of goldthread root.

Example 2

10 parts of borneol, 30 parts of cinnabar, 20 parts of borax, 60 parts of calcined gypsum, 3 parts of frankincense, 4 parts of myrrh, 30 parts of golden cypress, 3 parts of musk, 1 part of saffron and 5 parts of goldthread root.

Example 3

20 parts of borneol, 20 parts of cinnabar, 40 parts of borax, 40 parts of calcined gypsum, 6 parts of frankincense, 8 parts of myrrh, 20 parts of golden cypress, 2 parts of musk, 3 parts of saffron and 10 parts of goldthread root.

Example 4

30 parts of borneol, 10 parts of cinnabar, 60 parts of borax, 20 parts of calcined gypsum, 9 parts of frankincense, 4 parts of myrrh, 12 parts of golden cypress, 1 part of bezoar, 15 parts of dragon's blood and 15 parts of scutellaria baicalensis.

Example 5

10 parts of borneol, 30 parts of cinnabar, 20 parts of borax, 20 parts of calcined gypsum, 9 parts of frankincense, 12 parts of myrrh, 6 parts of golden cypress, 1 part of bezoar, 15 parts of dragon's blood and 5 parts of scutellaria baicalensis.

Example 6

18 parts of borneol, 20 parts of cinnabar, 35 parts of borax, 30 parts of calcined gypsum, 7 parts of frankincense, 8 parts of myrrh, 8 parts of golden cypress, 2 parts of bezoar, 9 parts of dragon's blood and 12 parts of scutellaria baicalensis.

Example 7

10 parts of borneol, 30 parts of cinnabar, 20 parts of borax, 60 parts of calcined gypsum, 4 parts of frankincense, 5 parts of myrrh, 18 parts of golden cypress, 3 parts of musk, 5 parts of goldthread root, 1 part of bezoar, 9 parts of dragon's blood, 30 parts of scutellaria baicalensis and 5 parts of catechu.

Example 8

30 parts of borneol, 10 parts of cinnabar, 60 parts of borax, 20 parts of calcined gypsum, 12 parts of frankincense, 15 parts of myrrh, 6 parts of golden cypress, 1 part of musk, 15 parts of goldthread root, 3 parts of bezoar, 3 parts of dragon's blood, 10 parts of scutellaria baicalensis and 15 parts of catechu.

Example 9

24 parts of borneol, 18 parts of cinnabar, 35 parts of borax, 42 parts of calcined gypsum, 10 parts of frankincense, 6 parts of myrrh, 13 parts of golden cypress, 3 parts of musk, 12 parts of goldthread root, 2 parts of bezoar, 5 parts of dragon's blood, 18 parts of scutellaria baicalensis and 11 parts of catechu.

Example 10

26 parts of borneol, 18 parts of cinnabar, 25 parts of borax, 50 parts of calcined gypsum, 6 parts of frankincense, 12 parts of myrrh, 16 parts of golden cypress, 5 parts of musk, 12 parts of goldthread root, 4 parts of bezoar, 13 parts of dragon's blood, 7 parts of scutellaria baicalensis and 6 parts of catechu.

Example 11

This example provides a preparation for treating skin wounds, which is an ointment prepared by grinding the Chinese medicinal composition provided in example 3 and mixing with a proper amount of vaseline.

Example 12

This example provides a preparation for treating skin wounds, which is an ointment prepared by grinding the Chinese medicinal composition provided in example 6 and mixing with a proper amount of vaseline.

Example 13

The embodiment provides a medicament for treating skin wounds, which is an ointment, and is prepared by grinding the traditional Chinese medicine composition provided in the embodiment 9 and mixing the ground traditional Chinese medicine composition with a proper amount of vaseline and a proper amount of beeswax.

Example 14

The embodiment provides a medicament for treating skin wounds, which is an ointment, and is prepared by grinding the traditional Chinese medicine composition provided in the embodiment 10 and mixing the ground traditional Chinese medicine composition with a proper amount of vaseline and a proper amount of beeswax.

Test examples

The therapeutic effect of the agent for skin wound treatment provided in example 11 was tested by the following test method.

1. Test site: a certain anorectal hospital in xi' an city.

2. And (3) testing time: 4-5 months in 2014

3. The testing personnel: after anorectal disease operation, the patients in the hospital adopt a double-blind random method and are respectively listed in a control group and an observation group for 66 cases, wherein 56 cases of men and 10 cases of women (because most female patients do not want to adopt a data acquisition method for wound surface photographing to protect the privacy) have the average age of 35.59 years. Among 66 cases, 48 cases of mixed hemorrhoids account for about 72.7%, 9 cases of perianal abscess account for about 13.6%, 5 cases of anal fistula account for about 7.6%, and 4 cases of compound anorectal diseases account for about 6.1%.

The grouping situation is as follows:

in the light of the age of the sex,

the observation group consisted of 33 cases, 30 men and 3 women, the ratio of men to women was 10:1, the average age was 34.79 years, 2 cases of persons greater than or equal to 65 years old, 6 cases of persons 45-64 years old, and 25 persons 20-44 years old accounting for 6.0%, 18.2% and 75.8%, respectively.

In the control group, 33 cases, 26 cases for men and 7 cases for women, the ratio of men to women is 3.71:1.0, the average age is 34.39 years, wherein 1 case is more than or equal to 65 years old, and 5 cases are 45-64 years old: 27 20-44 years old people respectively account for 3.0 percent, 15.2 percent and 81.8 percent, and compared with the two groups, the proportion of the male and the female in the treatment group is obviously higher than that in the control group, and the other two groups have no obvious difference.

In view of the classification of anorectal diseases,

in 33 observation groups, 21 mixed hemorrhoids, 6 perianal abscesses, 3 anal fistulas and 3 combined anorectal diseases account for 63.6 percent, 18.2 percent, 9.1 percent and 9.1 percent respectively.

In 33 control groups, 26 mixed hemorrhoids, 3 perianal abscesses, 3 anal fistulas and 1 compound anorectal disease: accounting for 81.8%, 9.1% and 3.0%, respectively.

Because patients with perianal abscess, anal fistula and compound anorectal diseases (one or three of mixed hemorrhoids, anal fistula and perianal abscess exist at the same elbow) need to be fully incised and drained during the operation, the operation wound surface is obviously larger than that of a mixed hemorrhoid operator, the three are combined into complicated and difficult wound surfaces, and the total 12 complicated and difficult wound surfaces in the observation group are calculated and calculated, and are about 36.4 percent. The total number of complex refractory wounds in the control group was 7, which accounted for about 21.2%. The proportion of complex refractory wounds in an observation group is obviously higher.

4. Clinical observation items and main method results:

the observation group was group a: the patient was replaced after the operation with the agent for treating skin wounds provided in example 11.

The control group was group B: the patients were replaced with the commercially available moist burn cream after surgery.

And the anorectal disease postoperative dressing change of the observation group and the control group comprises: according to the conventional local dressing change after anorectal disease operation, the local dressing change is mainly divided into four basic parts of wound surface cleaning, pollutant and necrotic tissue removing, intra-anal medicament application and local wound surface medicament application, and patients with active bleeding on the local wound surface of individual patients are subjected to hemostasis treatment. Except for local wound medication, the two groups of treatment principles are the same in all other links.

After the observation group operation, the wound surface of the lacuna is loosely filled with the gauze of the medicament for treating skin trauma provided in example 11 according to the requirements, the wound surface of the lacuna is pasted with the gauze of the medicament for treating skin trauma provided in example 11 for a patient with a large lacuna, and the lacuna part is filled with the saline gauze, the oil gauze or the sterile dressing so as to play the role of pressurizing and stopping bleeding. The control group of surgical wounds were topically applied with moist burn cream and then covered with sterile dressing.

Growth conditions and judgment standards of wound granulation tissues of two groups of patients: generally, after medical intervention measures are adopted in clinical researches on wound repair after anorectal disease operation, the time for granulation to start growing, the time for epithelial tissue to appear and the time for healing, the time for red swelling to disappear, the time for purulent secretion to disappear and the like are listed as standards for judging curative effects, so that the social burden of a patient is increased by obviously prolonging the clinical observation time (generally 20 to 30 days), on the other hand, the indexes are not completely related to the drug action, and are simultaneously influenced by a plurality of factors such as a local infection focus, wound packing, secondary injury during drug change, the nutritional status of the patient, the life and sanitary status and the like, so that the clinical observation and the instant effect of the drug are obviously in line with each other, the researchers conveniently combine the clinical practical situation to comprehensively consider, and seem to take the growth condition of the granulation tissue as the judgment standard, the method ensures that the correlation between the related medicaments and the dynamic evolution of granulation tissues is tighter, is more favorable for observing the direct influence of different medical intervention measures on the wound surface clinically, and judges and even makes an objective and correct judgment.

According to the definition of several different granulation tissues such as wound infection, inflammatory granulation tissue, edematous granulation tissue and fresh granulation tissue, the judgment standard of the granulation tissue growth condition is specially established by combining clinical observation:

0 minute: (wound infection) the wound is deep, grey and white, and has many surface secretions, and patients often have continuous pain on the wound.

1 minute: (aqueous granulation tissue): the granulation tissue of the wound margin (surface) is dark red, and a small amount of secretion can be seen on the smooth surface.

And 2, dividing: the granulation tissue on the wound margin (surface) is red, the particles on the surface are coarse and light, a small amount of secretion can be seen, and the granulation tissue can protrude out of the level of the wound margin.

And 3, dividing: the granulation tissue of (fresh granulation) wound margin (surface) is bright red, the surface particles are fine, the wound surface has obvious filling feeling, but does not protrude out of the level of the wound margin, no secretion exists, and the tissue is glossy.

A comparison of granulation tissue scores of the wounds of the two groups of patients is shown in table 1.

TABLE 1 granulation tissue score comparison of wounds from two groups of patients

Group of	Number of samples	Dressing change for the 1 st time after operation	After 72 hours	After 7 days
					Observation group	33	1.79±0.52	2.11±0.38	2.28±0.27
Control group	33	1.91±0.49	2.20±0.36	2.34±0.24

5. Discussion of results

As more and more patients with anorectal diseases tend to adopt operations to treat the diseases, and the patients with painful wound surface after operations, which is hard to endure, are difficult to forget. Therefore, how to reduce the pain and discomfort after the operation and accelerate the process of wound repair becomes an important choice for many anorectal disease medical institutions and professionals. People hope to be a new medicine which can promote the wound to heal quickly and reduce the pain and various discomforts of the wound after operation so as to avoid the negative effects of the selected operation patients on the social effect.

The wet burn ointment is applied to the wound surface (the thickness is less than 1mm) and has a good effect of protecting the wound surface tissue, and no obvious adverse reaction is found after the ointment is used for dressing change after anorectal operation for 3 years in the hospital. The pharmacological experimental research data show that the medicine has the effect of promoting wound healing after being locally coated, and has the effect of promoting ulcer healing on anus ulcer rat type caused by 20% acetic acid, so the medicine is the most commonly used external ointment for dressing change after a plurality of anorectal diseases in China.

The agent for treating skin wounds provided in example 11 is tried out on the wound surface after anorectal disease surgery for a plurality of months, has no adverse reaction, and has significantly improved clinical treatment effects in analgesia, anti-infection and healing time shortening compared with a wet burn ointment.

The patient Du forest is an observation group A17, the first 5 days after the perianal abscess incision drainage operation adopts the wet burn ointment for conventional dressing change, the pain of the wound of the patient is hard to endure and sleep easily after the 5 days after the operation, two larger wounds of 5.0x3.0cm and 5.0x2.0cm can be seen at the anus 12 point and the anus 9 point through the observation of the wound surface as shown in figure 1, and the wound depth at the anus 12 point reaches 5-7 cm. The patient agrees to apply the medicament for treating skin wounds provided in example 11 to the gauze packing and dressing change (5/13/2014, 10:28 min), and the patient has no pain on the wound surface from the last day to the next day, which shows that the medicament has obvious analgesic effect, and the patient is in the condition after healing as shown in fig. 2.

In general, the observation results of the group show that the medicine is suitable for the open wound surface after anorectal surgery, and has remarkable effects of relieving pain after the surgery, promoting tissue regeneration and accelerating wound healing.

Case 1

The queen women of the patient, the age of 37, inadvertently scalded the left foot with boiled water, burned with II-degree burn, started to use other medicines to treat pain, and the pain is difficult to endure in the sixth day, and the medicine for treating skin wound (hereinafter referred to as the medicine) provided by the embodiment 12 of the invention is used for treatment, and the treatment is basically cured after 15 days.

The treatment process is shown in fig. 3, and comprises the following steps from left to right:

1. after 10 minutes, the wound surface is relieved and no pain is caused;

2. after the patient uses the medicament for 2 days, the blisters disappear, and the swelling is obviously reduced;

3. 3 days after the patient uses the medicament;

4. the patient takes the medicament for 8 days;

5. after the patient uses the medicament for 10 days, the scald is healed, the patient stops using the medicament, and the patient waits for the natural recovery of the skin on the foot surface;

6. the patients return visit after stopping taking the medicine for 5 days, and the foot and face skin of the patients is completely recovered without scar residues.

Case 2

The patient is a plum, and a woman 23 years old is 7 days 8 months 8 in 2014 and carelessly scalds the right foot and the face of the foot when working. The patients are treated in private clinics nearby the same day, and the external application is insisted on the treatment for ten days, so that the scald is aggravated, and the wound infection and pain are difficult to endure. And in 8.19.2014 to the department specialized in burns in Xian Hospital, 1% deep II degree scald is diagnosed, after 24 days of treatment, the superficial burn is healed 1/3, and the rest 2/3 deep burn is healed, so that doctors inform that the scald needs to be treated through skin grafting operation or the scald cannot be healed. The patients have operation due to economic difficulty and fear. The medicament for treating skin wounds provided by the embodiment 12 of the invention is used for treatment instead of 9, 12 days in 2014, and after 19 days of medication, the wound surface of the deep II-degree scald is completely healed.

Case 3

The patients: the male is 90 years old, is paralyzed for a long time and bedridden, has a plurality of bedsores on the body, and can not be cured after being treated for a long time and has low fever for a long time by several prescriptions. The family members started to treat bedsores using the agent for treating skin wounds (hereinafter, referred to as the agent) provided in example 14 in 2014, 8/1. (6-7 months in 2014, the bedsore is treated by other medicines, and the curative effect is not obvious.)

The treatment process is shown in fig. 4, and comprises the following steps from top left to bottom right:

1. 6, 7 days in 2014, when a patient is seen in the beginning, the patient in 90 years old is bedridden for a long time and suffers from severe bedsore on the right span, and the patient suffers from low fever due to combined infection.

2. On 6/9/2014, the diameter of the bedsore of the patient is measured to be about 8cm, and a treatment plan is established for the patient to start the treatment.

3.6 and 11 days in 2014, after the medicament is used by a patient for 4 days, the wound infection is reduced, purulent secretion is obviously reduced, low fever is relieved, and the picture is taken after the medicament is coated.

4. 8 and 1 day in 2014, the patient uses the medicament for nearly 2 months, the patient has no low fever, and the general condition is obviously improved.

5. In 2014, 9, 12 days, the wound surface of a patient begins to shrink, the wound surface is full of muscles, the skin margin grows well, and the newly-grown skin has no scars.

6. In 2014, in 24 days in 10 months, the wound surface of a patient is obviously reduced, and the treatment condition of the wound surface is good.

7. In 11/3 days in 2014, the diameter of the wound surface of a patient is reduced by more than half, and the new skin is tender and has no scars.

8. In 2014, 11, 25 days, the wound surface of the patient is further reduced, and the skin growth condition is good.

9. In 2014, 12, 3 days, the wound surface of the patient is continuously reduced.

10. In 12 months and 16 days in 2014, the short diameter of the bedsore wound surface is reduced to 1.8 centimeters, and the wound surface is about to heal.

11. 24 days 12 months 2014, the bedsore wound surface is about to heal.

12. In 2014, 12 and 31 days, the bedsore wound surface is already healed, and the new skin has no scars.

The bedsore of a patient is treated by the medicament for several months, the original 8cm bedsore is completely healed, the newly-grown skin is healthy and elastic, no obvious scar is left, and the curative effect of the patient is consolidated by continuously using the medicament for a period of time.

Case 4

The patients: in men, age 32, diabetic foot, ulcer and necrosis of the tarnished toe of the right foot, necrosis of both metatarsals of the first phalange, debridement, removal of necrotic phalanges and partially necrotic metatarsals, wound packing with the gauze of the agent for skin wound treatment (hereinafter referred to as the agent) provided in example 13, and wound healing after 83 days of dressing change treatment.

The treatment process is shown in fig. 5, and comprises the following steps from left to right:

1. 2016.8.3 debridement, removal of necrotic phalanges and partially necrotic metatarsals.

2. 2016.8.3 dressing change is carried out by filling the wound with the gauze of the medicine for the first time.

3. 2016.8.8 the medicine is applied 3 times.

4. 2016.10.25 the wound will heal after 83 days of dressing change.

Case 5

The patients: for women, 28 years old, who had undergone double eyelid surgery at 4 pm on day 10 of month 6 and 2015, and who were afraid of wound pain after surgery, the doctor recommended to apply the agent for treating skin wounds (hereinafter referred to as the agent) provided in example 11 to the wound. The next day the patient taught that she was not painful to the wound the last night. The plaster is only smeared on the wound 3-5 times every day, no medicine is taken after the operation, no injection is made, and the wound is recovered quickly, so that the line is removed after 5 days of the operation. After the operation, the eyes basically return to normal after 13 days, and the eyes return to nature after 30 days.

The treatment process is shown in fig. 6, and comprises the following steps from left to right:

1. before double eyelid surgery;

2. applying the ointment after operation;

3. applying the ointment 3 days after operation;

4. removing stitches and applying the ointment after 5 days of operation;

5. applying the ointment 7 days after operation;

6. the double eyelids had recovered to nature after 30 days of operation.

Case 6

The patients: women, with cervical hypertrophy, erosion, HPV positive. After the surgical treatment, the recovery was carried out by using the agent for treating skin wounds (hereinafter referred to as the agent) provided in example 11 of the present invention in combination, and the skin wounds were completely cured after two months of treatment.

The treatment process is shown in fig. 7, and comprises the following steps from left to right:

1. when a patient receives a doctor, the picture of the cervix uteri is obviously hypertrophic and erosive, and the upper lip of the cervix uteri is convex;

2. after the operation treatment, the ointment is applied for recovery;

3. after 34 days of administration, the cervix of the patient becomes smaller obviously, and the surface of cervical erosion also becomes smaller and shallower obviously;

4. after 65 days of administration, the cervical erosion of the patient is about to cure;

5. after 69 days of administration, the cervical erosion of the patients is cured.

In summary, the embodiments of the present invention provide a traditional Chinese medicine composition and a medicament for treating skin wounds, which comprises main drugs of borneol, cinnabar, borax, calcined gypsum, frankincense, myrrh, phellodendron bark, etc. mixed according to a specific ratio, the mixture ratio of the drugs is scientific and reasonable, the synergistic effect can be fully exerted, the traditional Chinese medicine composition and the medicament have a good healing effect on various types of skin wounds, and have the characteristics of quick effect, patient pain alleviation, no toxic or side effect, no scar, etc. Meanwhile, the traditional Chinese medicine composition has a larger expansion space, according to the type difference of skin wounds, musk, goldthread root, bezoar, dragon's blood, scutellaria baicalensis, catechu and other medicines can be selectively added for matching, the curative effect of the traditional Chinese medicine composition on specific wound types is improved, and the traditional Chinese medicine composition has a better practical value.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating skin wounds is characterized by comprising the following components in parts by weight:

2. The traditional Chinese medicine composition for treating skin wounds according to claim 1 is characterized by comprising the following components in parts by weight:

3. The traditional Chinese medicine composition for treating skin wounds according to claim 1 is characterized by comprising the following components in parts by weight:

4. The traditional Chinese medicine composition for treating skin wounds according to claim 1 is characterized by comprising the following components in parts by weight:

5. The traditional Chinese medicine composition for treating skin wounds according to claim 1 is characterized by comprising the following components in parts by weight:

10-30 parts of borneol, 10-30 parts of cinnabar, 20-60 parts of borax, 20-60 parts of calcined gypsum, 4-8 parts of frankincense, 10-15 parts of myrrh, 12-18 parts of golden cypress, 3-5 parts of musk, 10-15 parts of goldthread root, 3-5 parts of bezoar, 10-15 parts of dragon's blood, 5-10 parts of scutellaria baicalensis and 5-10 parts of catechu.

6. A medicament for treating skin wounds, which comprises the traditional Chinese medicine composition as claimed in any one of claims 1 to 5 and pharmaceutically acceptable auxiliary materials.

7. The agent for treating skin wounds according to claim 6, characterized in that the agent is an ointment.