CN112189013A - 有机化合物 - Google Patents

有机化合物 Download PDF

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Publication number
CN112189013A
CN112189013A CN201980034445.2A CN201980034445A CN112189013A CN 112189013 A CN112189013 A CN 112189013A CN 201980034445 A CN201980034445 A CN 201980034445A CN 112189013 A CN112189013 A CN 112189013A
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CN
China
Prior art keywords
pde1
cancer
alkyl
tumor
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980034445.2A
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English (en)
Chinese (zh)
Inventor
L·P·文诺格勒
J·亨德里克
R·戴维斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intra Cellular Therapies Inc
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Intra Cellular Therapies Inc
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Filing date
Publication date
Application filed by Intra Cellular Therapies Inc filed Critical Intra Cellular Therapies Inc
Publication of CN112189013A publication Critical patent/CN112189013A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980034445.2A 2018-05-25 2019-05-24 有机化合物 Pending CN112189013A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862676638P 2018-05-25 2018-05-25
US62/676,638 2018-05-25
US201862688641P 2018-06-22 2018-06-22
US62/688,641 2018-06-22
PCT/US2019/033941 WO2019227004A1 (en) 2018-05-25 2019-05-24 Organic compounds

Publications (1)

Publication Number Publication Date
CN112189013A true CN112189013A (zh) 2021-01-05

Family

ID=68616034

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980034445.2A Pending CN112189013A (zh) 2018-05-25 2019-05-24 有机化合物

Country Status (11)

Country Link
US (1) US12636287B2 (enExample)
EP (2) EP3802545A4 (enExample)
JP (1) JP7493460B2 (enExample)
KR (1) KR20210013214A (enExample)
CN (1) CN112189013A (enExample)
AU (1) AU2019275453B2 (enExample)
BR (1) BR112020024037A2 (enExample)
CA (1) CA3099283A1 (enExample)
IL (2) IL278935B2 (enExample)
MX (1) MX2020012628A (enExample)
WO (1) WO2019227004A1 (enExample)

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WO2020146384A1 (en) 2019-01-07 2020-07-16 Intra-Cellular Therapies, Inc. Organic compounds
MX2024010993A (es) * 2022-03-11 2024-09-17 Intra Cellular Therapies Inc Compuestos organicos.

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AU2009322903A1 (en) 2008-12-06 2010-06-10 Intra-Cellular Therapies, Inc. Organic compounds
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EA201170769A1 (ru) 2008-12-06 2012-02-28 Интра-Селлулар Терапиз, Инк. Органические соединения
BRPI0922700A2 (pt) 2008-12-06 2015-08-11 Intracellular Therapies Inc Compostos orgânicos
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ES2717688T3 (es) * 2013-03-15 2019-06-24 Intra Cellular Therapies Inc Inhibidores de la PDE1 para uso en el tratamiento y/o prevención de lesiones de SNC, y enfermedades, trastornos o lesiones de SNP
WO2014169087A2 (en) 2013-04-10 2014-10-16 The Trustees Of Columbia University In The City Of New York Treatment of proximal spinal muscular atrophy
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US4690935A (en) * 1983-03-31 1987-09-01 Wayne State University Inhibition of tumor growth and metastasis with calcium channel blocker compounds
US20140194396A1 (en) * 2011-06-10 2014-07-10 Intra-Cellular Therapies, Inc. Organic compounds
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Publication number Publication date
EP3802545A1 (en) 2021-04-14
EP4520399A2 (en) 2025-03-12
MX2020012628A (es) 2021-01-29
AU2019275453B2 (en) 2023-12-21
US20210205310A1 (en) 2021-07-08
IL278935B2 (en) 2026-04-01
IL278935B1 (en) 2025-12-01
JP7493460B2 (ja) 2024-05-31
BR112020024037A2 (pt) 2021-02-09
CA3099283A1 (en) 2019-11-28
US12636287B2 (en) 2026-05-26
EP4520399A3 (en) 2025-03-26
IL278935A (en) 2021-01-31
JP2021525705A (ja) 2021-09-27
WO2019227004A1 (en) 2019-11-28
EP3802545A4 (en) 2022-03-16
AU2019275453A1 (en) 2020-12-03
IL322048A (en) 2025-09-01
KR20210013214A (ko) 2021-02-03

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