CN1121713A - 丝氨酸衍生物 - Google Patents

丝氨酸衍生物 Download PDF

Info

Publication number
CN1121713A
CN1121713A CN94191891A CN94191891A CN1121713A CN 1121713 A CN1121713 A CN 1121713A CN 94191891 A CN94191891 A CN 94191891A CN 94191891 A CN94191891 A CN 94191891A CN 1121713 A CN1121713 A CN 1121713A
Authority
CN
China
Prior art keywords
group
thienyl
hydrogen atom
methyl
medicine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN94191891A
Other languages
English (en)
Chinese (zh)
Inventor
野田一生
岩田正洋
坂本修一
越谷和雄
森田琢磨
小原厚行
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of CN1121713A publication Critical patent/CN1121713A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CN94191891A 1993-04-27 1994-04-26 丝氨酸衍生物 Pending CN1121713A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP123454/93 1993-04-27
JP12345493 1993-04-27
JP23642893 1993-09-22
JP236428/93 1993-09-22

Publications (1)

Publication Number Publication Date
CN1121713A true CN1121713A (zh) 1996-05-01

Family

ID=26460383

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94191891A Pending CN1121713A (zh) 1993-04-27 1994-04-26 丝氨酸衍生物

Country Status (7)

Country Link
US (1) US5834460A (enExample)
EP (1) EP0696586A1 (enExample)
CN (1) CN1121713A (enExample)
CA (1) CA2160459A1 (enExample)
HU (1) HUT75032A (enExample)
TW (1) TW290548B (enExample)
WO (1) WO1994025450A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW414795B (en) * 1996-07-01 2000-12-11 Yamanouchi Pharma Co Ltd A thiophene derivative and the pharmaceutical composition
ES2164040T3 (es) 1998-04-14 2008-02-01 The General Hospital Corporation Uso de d-serina o de d-alanina para el tratamiento de la esquizofrenia.
EP1219607B1 (en) * 1999-09-02 2011-04-06 Shionogi & Co., Ltd. Integrase inhibitors containing aromatic heterocycle derivatives
WO2007060409A1 (en) * 2005-11-23 2007-05-31 Astrazeneca Ab L-alanine derivatives
JP2009539815A (ja) * 2006-06-09 2009-11-19 アストラゼネカ アクチボラグ 固形腫瘍の治療用のａ５ｂ１アンタゴニストとしてのＮ−（ベンゾイル）−Ｏ−［２−（ピリジン−２−イルアミノ）エチル］−Ｌ−チロシン誘導体と関連化合物
WO2008093065A1 (en) * 2007-01-29 2008-08-07 Astrazeneca Ab L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS
WO2008125811A1 (en) * 2007-04-11 2008-10-23 Astrazeneca Ab N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4382929A (en) * 1979-10-23 1983-05-10 Glaxo Group Limited Thiophene derivatives and their pharmaceutical compositions and method of use
US4598153A (en) * 1984-12-19 1986-07-01 The United States Of America As Represented By The Department Of Health And Human Services Metaphit, a specific acylating agent for the [3 H] phencyclidine
EP0446798B1 (en) * 1990-03-13 1994-11-23 Hoechst-Roussel Pharmaceuticals Incorporated 1-alkyl-, 1-alkenyl- and 1-alkynylaryl-2-amino-1, 3-propanediols and related compounds, a process and intermediates for their preparation and their use as medicaments
KR100196888B1 (ko) * 1991-04-17 1999-06-15 파마시아 앤드 업죤 컴패니 중추 작용성을 갖는 신규한 치환된 페닐아자사이클로 알칸
EP0596120A4 (en) * 1991-08-09 1994-07-06 Yoshitomi Pharmaceutical Thiophene compound.
JPH05262759A (ja) * 1992-01-23 1993-10-12 Yoshitomi Pharmaceut Ind Ltd チオフェン化合物

Also Published As

Publication number Publication date
EP0696586A4 (enExample) 1996-03-27
AU6582494A (en) 1994-11-21
CA2160459A1 (en) 1994-11-10
WO1994025450A1 (fr) 1994-11-10
HUT75032A (en) 1997-03-28
US5834460A (en) 1998-11-10
TW290548B (enExample) 1996-11-11
EP0696586A1 (en) 1996-02-14
HU9503072D0 (en) 1995-12-28
AU681655B2 (en) 1997-09-04

Similar Documents

Publication Publication Date Title
CN1189170C (zh) 噻吩基唑基烷氧基乙胺,它们的制备以及它们作为药物的应用
EP1680418B1 (fr) Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
EP1682503B1 (fr) Derives de n-[phenyl(alkylpiperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
EP1499589B1 (fr) Derives de n-¬phenyl(piperidin-2-yl)methyl|benzamide, leur preparation et leur application en therapeutique
CA2542647C (fr) Derives de n-heterocyclylmethylbenzamides, leur preparation et leur application en therapeutique
FR2861074A1 (fr) Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
JP2008528674A (ja) 治療効果を有する新規化合物
CA2542727A1 (fr) Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide, et n-[[azepan-2-yl)phenylmethyl]benzamide, leur preparation et leur application en therapeutique
FR2735127A1 (fr) Nouvelles piperazines heteroaromatiques utiles comme medicaments.
CN1190393A (zh) 二芳基二胺衍生物及其作为δ－阿片样物质(拮抗)激动剂的用途
CN1176080C (zh) 茚并一,萘并一和苯并环庚二氢噻唑衍生物,它们的制备以及它们作为降低食欲药的用途
JP2015526496A (ja) トリアゾールカルボキサミド誘導体
KR100331407B1 (ko) 신경이완제등으로이용되는n-치환아자비시클로헵탄유도체
CN1121713A (zh) 丝氨酸衍生物
CN1301258A (zh) 苯并n－氧化噁二唑衍生物和它们在治疗心绞痛中的应用
EP2077837A2 (fr) Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique.
US5521209A (en) N-substituted azabicyclo[3.2.0]heptane derivatives as neuroleptics, the preparation and use thereof
EP0673933A1 (fr) Aminoalkyl benzoxazolinones et benzothiazolinones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
WO2007109098A2 (en) HYDROXY AND KETO-SUBSTITUTED β-LACTAMYL ALKANEDIOIC ACIDS
EP0718286A1 (en) 3-Alkoxybenzylpiperidine derivatives as melatonergic agents
CN1255131A (zh) 作为氧化氮合酶抑制剂的脒衍生物
CN104768950A (zh) 吡嗪衍生物
CN1152026C (zh) 多环的2-氨基二氢噻唑体系、它们的制备方法和它们作为药物的用途
CN1234694C (zh) 新的咪唑啉化合物、其制备方法及包含它们的药物组合物
EP1773823B1 (fr) Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication