CN112135627A - 细胞内递送生物分子以修饰免疫应答 - Google Patents

细胞内递送生物分子以修饰免疫应答 Download PDF

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Publication number
CN112135627A
CN112135627A CN201980030600.3A CN201980030600A CN112135627A CN 112135627 A CN112135627 A CN 112135627A CN 201980030600 A CN201980030600 A CN 201980030600A CN 112135627 A CN112135627 A CN 112135627A
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cell
cells
modified
antigen
adjuvant
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Chinese (zh)
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S·洛克希德
L·塔拉里科
A·韦森特·苏亚雷斯
M·布蒂
H·伯恩斯坦
K·布拉戈维奇
A·R·沙雷
K·赫拉维蒂
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Stemcell Technologies Canada Inc
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SQZ Biotechnologies Co
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CN201980030600.3A 2018-03-12 2019-03-11 细胞内递送生物分子以修饰免疫应答 Pending CN112135627A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862641987P 2018-03-12 2018-03-12
US62/641,987 2018-03-12
US201862738941P 2018-09-28 2018-09-28
US62/738,941 2018-09-28
US201962794516P 2019-01-18 2019-01-18
US62/794,516 2019-01-18
PCT/US2019/021705 WO2019178006A2 (en) 2018-03-12 2019-03-11 Intracellular delivery of biomolecules to modify immune response

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CN112135627A true CN112135627A (zh) 2020-12-25

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US (1) US20240374654A2 (https=)
EP (1) EP3765068A2 (https=)
JP (2) JP7595827B2 (https=)
KR (1) KR20200130835A (https=)
CN (1) CN112135627A (https=)
AU (2) AU2019234550B2 (https=)
BR (1) BR112020018612A2 (https=)
CA (1) CA3093828A1 (https=)
CO (1) CO2020012584A2 (https=)
CR (1) CR20200460A (https=)
IL (1) IL277188B2 (https=)
MA (1) MA52010A (https=)
MX (1) MX2020009439A (https=)
PH (1) PH12020551436A1 (https=)
SG (1) SG11202008864VA (https=)
TW (1) TW202003019A (https=)
WO (1) WO2019178006A2 (https=)

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EP3344575B1 (en) 2015-09-04 2020-04-15 SQZ Biotechnologies Company Intracellular delivery of biomolecules to cells comprising a cell wall
JP7602702B2 (ja) 2016-05-03 2024-12-19 ステムセル テクノロジーズ カナダ インコーポレーテッド 寛容性を誘導するための生体分子の細胞内送達
US12599656B2 (en) 2018-03-12 2026-04-14 Stemcell Technologies Canada Inc. Methods for treating HPV-associated diseases
WO2020014543A2 (en) 2018-07-11 2020-01-16 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
JP6884450B2 (ja) * 2019-02-14 2021-06-09 学校法人獨協学園獨協医科大学 Ｔ細胞ワクチン
CA3131701A1 (en) 2019-02-28 2020-09-03 Sqz Biotechnologies Company Delivery of biomolecules to pbmcs to modify an immune response
US11679388B2 (en) 2019-04-08 2023-06-20 Sqz Biotechnologies Company Cartridge for use in a system for delivery of a payload into a cell
AU2021272340A1 (en) 2020-05-11 2022-12-08 F. Hoffmann-La Roche Ag Combination therapy with modified pbmcs and an immunoconjugate
EP4188425B1 (en) 2020-07-29 2025-05-14 Stemcell Technologies Canada Inc. Methods to stimulate immune responses to mutant ras using anucleate cells
WO2022026620A1 (en) 2020-07-29 2022-02-03 Sqz Biotechnologies Company Methods to stimulate immune responses to mutant ras using nucleated cells
TW202241466A (zh) 2020-12-29 2022-11-01 美商Ｓｑｚ生物科技公司 以經修飾ｐｂｍｃ治療癌症之方法
JP2024503279A (ja) 2020-12-29 2024-01-25 スクイーズ バイオテクノロジーズ カンパニー Ｐｂｍｃの凍結保存のための製剤
US20220233676A1 (en) * 2020-12-29 2022-07-28 Sqz Biotechnologies Company Formulations of activating antigen carriers
US20220296691A1 (en) 2020-12-29 2022-09-22 Sqz Biotechnologies Company Methods for treating cancer with activating antigen carriers
CN115252772A (zh) * 2021-04-30 2022-11-01 华普生物技术(江苏)股份有限公司 人工合成的含CpG单链脱氧寡核苷酸在疫苗中的应用
WO2023010090A1 (en) 2021-07-29 2023-02-02 Sqz Biotechnologies Company Methods to generate enhanced tumor infiltrating lymphocytes through microfluidic delivery
WO2023087009A1 (en) 2021-11-11 2023-05-19 Sqz Biotechnologies Company Methods to generate enhanced tumor infiltrating lymphocytes through microfluidic delivery
CA3262748A1 (en) 2022-07-28 2024-02-01 Stemcell Technologies Canada Inc. IMPROVED ANTIGEN-PRESENTING CELL FORMULATIONS
CA3262756A1 (en) 2022-07-28 2024-02-01 Stemcell Technologies Canada Inc. CANCER TREATMENT METHODS WITH ENHANCED ANTIGEN-PRESENTING CELLS

Citations (5)

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