CN112111495A - Tlr-4特异性适配体及其应用 - Google Patents

Tlr-4特异性适配体及其应用 Download PDF

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Publication number
CN112111495A
CN112111495A CN202010953057.9A CN202010953057A CN112111495A CN 112111495 A CN112111495 A CN 112111495A CN 202010953057 A CN202010953057 A CN 202010953057A CN 112111495 A CN112111495 A CN 112111495A
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tlr
aptamer
seq
present
aptamers
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Inventor
I·丽萨苏阿因赫尔南德斯
V·M·冈萨雷斯穆尼奥斯
G·费尔南德斯戈麦斯查孔
M·á·摩洛桑切斯
M·E·马丁帕尔马
A·莫拉加韦内斯
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Merck Healthcare Group
Merck Patent GmbH
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Aupu Tower Target Corp
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CN202010953057.9A 2014-06-24 2015-06-24 Tlr-4特异性适配体及其应用 Pending CN112111495A (zh)

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ESP201430955 2014-06-24
ES201430955A ES2555160B1 (es) 2014-06-24 2014-06-24 Aptámeros específicos de TLR-4 y usos de los mismos
CN201580034070.1A CN106459980B (zh) 2014-06-24 2015-06-24 Tlr-4特异性适配体及其应用

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ES2555160B1 (es) * 2014-06-24 2016-10-25 Aptus Biotech, S.L. Aptámeros específicos de TLR-4 y usos de los mismos
CA3030974A1 (en) 2016-07-15 2018-01-18 President And Fellows Of Harvard College Glycolipid compositions and methods of use
EP3494994A1 (en) * 2017-12-07 2019-06-12 Universität zu Köln Combinations of ripk1- and ikk-inhibitors for the prevention or treatment of immune diseases
IL280880B2 (en) 2018-08-27 2025-04-01 Regeneron Pharma Using Raman Spectroscopy in Downstream Purification
AU2019347774A1 (en) 2018-09-28 2021-03-25 Nutcracker Therapeutics, Inc. Lipid nanoparticle formulations comprising lipidated cationic peptide compounds for nucleic acid delivery
CN113423833B (zh) * 2018-09-28 2024-09-17 奥曼尼提纳米有限公司 用于选择功能性适体的方法和组合物
WO2020069569A1 (en) 2018-10-02 2020-04-09 WearOptimo Pty Ltd Actuator system
US20210338158A1 (en) 2018-10-02 2021-11-04 WearOptimo Pty Ltd Measurement system
US20220233572A1 (en) * 2019-05-16 2022-07-28 Aptatargets, S.L. Treatment of tlr-4 mediated diseases and conditions with aptamers targeting tlr-4
CN111474336B (zh) * 2020-03-21 2023-07-28 南昌大学 一种铁氰化镍纳米粒化学发光适体传感器的制备方法及基于其检测8-OhdG的方法
WO2021257494A1 (en) * 2020-06-15 2021-12-23 President And Fellows Of Harvard College Methods for modulating tlr4 signaling
CN114152599B (zh) * 2021-12-01 2023-10-13 中国农业大学 一种基于双劈裂功能核酸变构的孔雀石绿生物传感器
CN114836425A (zh) * 2022-02-25 2022-08-02 温州医科大学附属眼视光医院 检测小胶质细胞的核酸适体及应用
WO2024146930A1 (en) 2023-01-05 2024-07-11 Aptatargets, S.L. Aptoll molecules for the treatment of ischemic stroke and intracranial hemorrhages
WO2024240750A1 (en) 2023-05-22 2024-11-28 Aptatargets, S.L. New tlr-4 antagonist aptamers

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