CN112089056A - 改善记忆力益生菌组合物 - Google Patents
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Abstract
本发明公开了改善记忆力益生菌组合物，属于益生菌的所有相关食品产业领域。它包括副干酪乳杆菌和磷脂酰丝氨酸粉。所述副干酪乳杆菌合并有效量为每日补充100亿～600亿，即1010 cfu/day～6*1010 cfu/day的副干酪乳杆菌菌量和每日0.6克～2.6克磷脂酰丝氨酸粉。本发明中的副干酪乳杆菌合并磷酯酰丝氨酸粉，作为改善记忆力的食品补充或药物之组合物。该组合物可提高空间记忆力，提升抗氧化和抗发炎因子的表达，改善焦虑，提高睡眠，提升神经细胞新生与修复能力，缓解脑部疲劳，促进注意力集中、提高警觉性和记忆力。
Description
技术领域
本发明涉及改善记忆力益生菌组合物，属于益生菌的所有相关食品产业领域。
背景技术
肠道通过20~60亿神经元（neuron）与大脑紧密连接（JB Furness, 2006），肠道里的微生物和大脑通过脑肠轴（gut-brain axis）保持着双向沟通。越来越多的研究表明，益生菌（probiotics）能够显著影响焦虑、抑郁、压力、自闭症，甚至是学习和记忆（Liu X,2015）。
记忆存储在神经细胞之间的连接点上的，一个神经细胞可与其他神经细胞建立多达几千个连接点。记忆不会因为一个神经细胞的死亡而丢失，而只会由于相关连接点的丢失使记忆逐渐减弱，模糊。随着年龄的增加、压力、睡眠等等因素，大脑的记忆功能逐渐衰退，有效的脑力锻炼和营养滋补是减缓记忆衰退的有效武器（Akers K G, 2014）。
研究人员对加速老化鼠（senescence accelerated mouse prone 8 mice,SAMP8）进行水迷宫实验（morris water maze test），根据老鼠在水中寻找隐藏的“逃生通道”的表现，测试他们空间记忆的能力。研究表明，长期食用副干酪乳杆菌Lactobacillus paracasei PS23之老化鼠停留在正确“逃生”位置的时间增加，揭示其记忆力比没有食用PS23的老鼠显著优异（Huang S Y, 2018）。
最近的研究表明，益生菌利用脑肠轴增加神经单胺（neural monoamine）的水平，如多巴胺（dopamine, DA），血清素（serotonin, 5-HT）和脑源性神经营养因子（brain-derived neurotrophy factor, BDNF），这对于神经可塑性和存活是至关重要的（Huang SY, 2018）。随着年龄的增加，预防DA、5-HT和BDNF水平的降低被认为可以降低焦虑和记忆缺陷（Vilela T C, 2017）的发生率，提高认知能力。焦虑与睡眠息息相关，睡眠障碍是构成焦虑症的核心特征（Mellman T A, 2006），而记忆是通过睡眠来巩固，良好的睡眠是对于擦除无用记忆，巩固有用记忆至关重要（Fattinger S, 2017）。研究表明，食用PS23能显著提高机体SOD和GPx的表达水平，减轻氧化对机体的伤害，同时提高机体内DA、5-HT和BDNF水平，改善焦虑状况，提高睡眠能力，提高神经细胞新生与记忆能力（Huang S Y, 2018）。
磷脂酰丝氨酸（phosphatidylserine, PS），是维持大脑神经细胞膜流动性、通透性的重要物质，能够营养和活化脑中各种酶的活性，增加脑神经细胞突触的数目，延缓神经递质的减少，可以提高大脑机能，修复大脑神经损伤，缓解脑部疲劳，促进注意力集中、提高警觉性和记忆力（周芳, 2008）。
目前市场上改善记忆类产品多种多样，主要包括中药、西药、药食同源物质或组合。存在一定毒副作用，不适宜长期服用，作用机制单一，适用人群范围较宅。因此，需要开发一种能长期服用的，能够通过减轻精神压力、改善焦虑状况、提升睡眠质量、清除氧化自由基、提升自体免疫力、修复大脑神经损伤、缓解脑部疲劳、促进神经细胞新生等方法合并运用促进注意力集中、提高记忆力，为改善记忆力相关市场提供一个全方位的解决方案。
发明内容
本发明所要解决的技术问题在于：提供改善记忆力益生菌组合物，解决改善记忆力相关市场上急需解决的问题。
本发明所要解决的技术问题采取以下技术方案来实现：
改善记忆力益生菌组合物，包括副干酪乳杆菌和磷脂酰丝氨酸粉，所述副干酪乳杆菌合并磷脂酰丝氨酸粉有效量为每日补充100亿～600亿，即1010 cfu/day～6*1010 cfu/day的副干酪乳杆菌菌量和每日0.6克～2.6克磷脂酰丝氨酸粉。
作为优选实例，所述磷脂酰丝氨酸粉为大豆磷脂酰丝氨酸粉。
作为优选实例，所述副干酪乳杆菌合并磷脂酰丝氨酸粉的有效量为每日补充100亿，即1010 cfu/day的副干酪乳杆菌菌量和每日0.6克磷脂酰丝氨酸粉。
作为优选实例，所述副干酪乳杆菌合并磷脂酰丝氨酸粉可进一步包括药学上可接受之载剂、赋形剂或稀释剂；并可进一步制成流体乳品、浓缩牛奶、优酪乳、酸乳、冷冻优格、乳杆菌发酵饮料、奶粉、冰淇淋、乳酪、干酪、豆浆、发酵豆浆、蔬果汁、果汁、运动饮料、甜点、果冻、糖果、婴儿食品、健康食品、动物饲料、中草药组合物或膳食补充品。
本发明的有益效果是：本发明中的副干酪乳杆菌合并磷酯酰丝氨酸粉，作为改善记忆力的食品补充或药物之组合物，该组合物可提高空间记忆力，提升抗氧化和抗发炎因子的表达，改善焦虑，提高睡眠，提升神经细胞新生与修复能力，缓解脑部疲劳，促进注意力集中、提高警觉性和记忆力。
具体实施方式
为了对本发明的技术手段、创作特征、达成目的与功效易于明白了解，下面结合具体实施例，进一步阐述本发明。
实施例一
改善记忆力益生菌组合物，包括副干酪乳杆菌和磷脂酰丝氨酸粉，所述副干酪乳杆菌合并磷脂酰丝氨酸粉的有效量为每日补充100亿，即1010 cfu/day的副干酪乳杆菌菌量和每日0.6克磷脂酰丝氨酸粉，所述磷脂酰丝氨酸粉采用大豆磷脂酰丝氨酸粉。
实施例二
改善记忆力益生菌组合物，包括副干酪乳杆菌和磷脂酰丝氨酸粉，所述副干酪乳杆菌合并磷脂酰丝氨酸粉的有效量为每日补充200亿，即2*1010 cfu/day的副干酪乳杆菌菌量和每日1.0克磷脂酰丝氨酸粉，所述磷脂酰丝氨酸粉采用大豆磷脂酰丝氨酸粉。
实施例三
改善记忆力益生菌组合物，包括副干酪乳杆菌和磷脂酰丝氨酸粉，所述副干酪乳杆菌合并磷脂酰丝氨酸粉的有效量为每日补充300亿，即3*1010 cfu/day的副干酪乳杆菌菌量和每日1.4克磷脂酰丝氨酸粉，所述磷脂酰丝氨酸粉采用大豆磷脂酰丝氨酸粉。
实施例四
改善记忆力益生菌组合物，包括副干酪乳杆菌和磷脂酰丝氨酸粉，所述副干酪乳杆菌合并磷脂酰丝氨酸粉的有效量为每日补充400亿，即4*1010 cfu/day的副干酪乳杆菌菌量和每日1.8克磷脂酰丝氨酸粉，所述磷脂酰丝氨酸粉采用大豆磷脂酰丝氨酸粉。
实施例五
改善记忆力益生菌组合物，包括副干酪乳杆菌和磷脂酰丝氨酸粉，所述副干酪乳杆菌合并磷脂酰丝氨酸粉的有效量为每日补充500亿，即5*1010 cfu/day的副干酪乳杆菌菌量和每日2.2克磷脂酰丝氨酸粉，所述磷脂酰丝氨酸粉采用大豆磷脂酰丝氨酸粉。
实施例六
改善记忆力益生菌组合物，包括副干酪乳杆菌和磷脂酰丝氨酸粉，所述副干酪乳杆菌合并磷脂酰丝氨酸粉的有效量为每日补充600亿，即6*1010 cfu/day的副干酪乳杆菌菌量和每日2.6克磷脂酰丝氨酸粉，所述磷脂酰丝氨酸粉采用大豆磷脂酰丝氨酸粉。
研究方法及进行步骤
1. 人体试食实验:
选择身体健康，并符合以下条件的志愿者作为受试者:年龄30-60岁，高中以上文化，未接受过类似的测试，I年内未服用过与改善记忆有关的药品或保健食品；
第一次测试受试者70例，按记忆商高低排队，经检验两组记忆商均衡后，随机分为试验组60例和对照组10例；
试验组按照上述六个实施例（每组10例）服用本品，对照组服用安慰剂。连续服用30天后，两组进行第二次测试；
采用临床记忆量表来评价受试者的记忆水平；
测试内容包括:指向记忆、联想学习、图像自由回忆、无意义图形再认、人像特点联系回忆。将测得的分数(原始分)换算成量表分；
比较两组之间各项内容的量表分，计算总量表分，查得记忆商后比较两组之间的差异；
服用本品后明显提高指向记忆、联想学习、无意义图形再认、人像特点联系回忆水平，明显提高记忆商值，表明本品确有较好的改善记忆作用。
2. 动物试验：Morris水迷宫试验
Morris水迷宫试验在圆形水池(直径960毫米，高度50厘米)中进行；
包含40厘米深的水 (25±2℃)，老鼠被训练去寻找下面的平台水面每天四次，持续六天；
老鼠们被引导着爬上平台他们无法在60秒内逃到平台上；
第7天，平台被移走了给老鼠60秒的时间在迷宫中搜索；
第8天，用该方法对游泳路径进行了分析视频跟踪软件(Noldus；
第9天，游泳时间在前平台象限和总象限四个象限的游泳时间均记录为60 s；
结果表明，小鼠的空间记忆力明显提升。
以上显示和描述了本发明的基本原理和主要特征和本发明的优点。本行业的技术人员应该了解，本发明不受上述实施例的限制，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。
Claims (5)
1.改善记忆力益生菌组合物，其特征在于：包括副干酪乳杆菌和磷脂酰丝氨酸粉，所述副干酪乳杆菌合并磷脂酰丝氨酸粉有效量为每日补充100亿～600亿，即1010 cfu/day～6*1010 cfu/day的副干酪乳杆菌菌量和每日0.6克～2.6克磷脂酰丝氨酸粉。
2.根据权利要求1所述的改善记忆力益生菌组合物，其特征在于：所述副干酪乳杆菌为副干酪乳杆菌PS23。
3.根据权利要求1所述的改善记忆力益生菌组合物，其特征在于：所述磷脂酰丝氨酸粉为大豆磷脂酰丝氨酸粉。
4.根据权利要求1所述的改善记忆力益生菌组合物，其特征在于：所述副干酪乳杆菌合并磷脂酰丝氨酸粉的有效量为每日补充100亿，即1010 cfu/day的副干酪乳杆菌菌量和每日0.6克磷脂酰丝氨酸粉。
5.根据权利要求1所述的改善记忆力益生菌组合物，其特征在于：所述副干酪乳杆菌合并磷脂酰丝氨酸粉可进一步包括药学上可接受之载剂、赋形剂或稀释剂；并可进一步制成流体乳品、浓缩牛奶、优酪乳、酸乳、冷冻优格、乳杆菌发酵饮料、奶粉、冰淇淋、乳酪、干酪、豆浆、发酵豆浆、蔬果汁、果汁、运动饮料、甜点、果冻、糖果、婴儿食品、健康食品、动物饲料、中草药组合物或膳食补充品。
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