CN112055709A - 吡嗪化合物和其用途 - Google Patents

吡嗪化合物和其用途 Download PDF

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Publication number
CN112055709A
CN112055709A CN201980006428.8A CN201980006428A CN112055709A CN 112055709 A CN112055709 A CN 112055709A CN 201980006428 A CN201980006428 A CN 201980006428A CN 112055709 A CN112055709 A CN 112055709A
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CN
China
Prior art keywords
amino
methyl
pyrazine
carboxamide
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980006428.8A
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English (en)
Chinese (zh)
Inventor
齐长河
徐汉忠
曾庆北
杨振帆
张小林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dizhe Jiangsu Pharmaceutical Co ltd
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Dizhe Jiangsu Pharmaceutical Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Dizhe Jiangsu Pharmaceutical Co ltd filed Critical Dizhe Jiangsu Pharmaceutical Co ltd
Priority to CN202010656947.3A priority Critical patent/CN111747954B/zh
Priority to CN202210871450.2A priority patent/CN115181092B/zh
Priority to CN202010657665.5A priority patent/CN112279837B/zh
Publication of CN112055709A publication Critical patent/CN112055709A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • C—CHEMISTRY; METALLURGY
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
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  • Urology & Nephrology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980006428.8A 2018-08-17 2019-08-16 吡嗪化合物和其用途 Pending CN112055709A (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN202010656947.3A CN111747954B (zh) 2018-08-17 2019-08-16 吡嗪化合物和其用途
CN202210871450.2A CN115181092B (zh) 2018-08-17 2019-08-16 吡嗪化合物和其用途
CN202010657665.5A CN112279837B (zh) 2018-08-17 2019-08-16 吡嗪化合物和其用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2018/101006 2018-08-17
CN2018101006 2018-08-17
PCT/CN2019/100996 WO2020035052A1 (en) 2018-08-17 2019-08-16 Pyrazine compounds and uses thereof

Related Child Applications (3)

Application Number Title Priority Date Filing Date
CN202010657665.5A Division CN112279837B (zh) 2018-08-17 2019-08-16 吡嗪化合物和其用途
CN202210871450.2A Division CN115181092B (zh) 2018-08-17 2019-08-16 吡嗪化合物和其用途
CN202010656947.3A Division CN111747954B (zh) 2018-08-17 2019-08-16 吡嗪化合物和其用途

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CN112055709A true CN112055709A (zh) 2020-12-08

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US (3) US10898481B2 (https=)
EP (1) EP3837250A4 (https=)
JP (1) JP7540996B2 (https=)
KR (1) KR102816365B1 (https=)
CN (1) CN112055709A (https=)
AR (1) AR115985A1 (https=)
AU (1) AU2019323035B2 (https=)
BR (1) BR112021002895A2 (https=)
CA (1) CA3107365A1 (https=)
MX (2) MX2021001884A (https=)
TW (1) TW202023559A (https=)
WO (1) WO2020035052A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11254670B2 (en) 2019-01-18 2022-02-22 Nuvation Bio Inc. 1,8-naphthyridinone compounds and uses thereof
US11306071B2 (en) 2019-01-18 2022-04-19 Nuvation Bio Inc. Heterocyclic compounds as adenosine antagonists

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019018584A1 (en) 2017-07-18 2019-01-24 GiraFpharma LLC HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS
AU2019323035B2 (en) * 2018-08-17 2024-11-07 Dizal (Jiangsu) Pharmaceutical Co., Ltd. Pyrazine compounds and uses thereof
JP2022517418A (ja) * 2019-01-18 2022-03-08 ニューベイション・バイオ・インコーポレイテッド アデノシンアンタゴニストとしてのヘテロ環式化合物
WO2021146629A1 (en) * 2020-01-17 2021-07-22 Nuvation Bio Inc. Heterocyclic compounds as adenosine antagonists
WO2021146631A1 (en) * 2020-01-17 2021-07-22 Nuvation Bio Inc. Heterocyclic compounds as adenosine antagonists
CA3182410A1 (en) 2020-05-04 2021-11-11 Volastra Therapeutics, Inc. Imino sulfanone inhibitors of enpp1
US12091412B2 (en) 2020-06-16 2024-09-17 Volastra Therapeutics, Inc. Heterocyclic inhibitors of ENPP1
KR102621694B1 (ko) * 2022-09-15 2024-01-08 주식회사 스탠다임 아데노신 a2a 수용체 길항제 및 이의 용도
US11987581B1 (en) 2023-12-19 2024-05-21 King Faisal University Imidazo[1,2-c]pyrido[3,4-e]pyrimidine-2-carboxylic acids as CK2 inhibitors
US11964974B1 (en) 2024-01-08 2024-04-23 King Faisal University Imidazo[1,2-c]pyrido[3,4-e]pyrimidine-3-carboxylic acids as CK2 inhibitors
WO2025191185A1 (en) * 2024-03-15 2025-09-18 Domain Therapeutics Azine-based compounds as par-2 inhibitors and therapeutic uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2543644A1 (en) 2003-10-27 2005-05-06 Astellas Pharma Inc. Pyrazine derivatives and pharmaceutical use thereof
CN1871231A (zh) * 2003-10-27 2006-11-29 安斯泰来制药有限公司 吡嗪衍生物及其医药用途
CN1938296A (zh) * 2004-04-01 2007-03-28 安斯泰来制药有限公司 作为腺苷拮抗剂的吡嗪衍生物及其制药用途
WO2019018584A1 (en) * 2017-07-18 2019-01-24 GiraFpharma LLC HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS
AU2019323035B2 (en) * 2018-08-17 2024-11-07 Dizal (Jiangsu) Pharmaceutical Co., Ltd. Pyrazine compounds and uses thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11254670B2 (en) 2019-01-18 2022-02-22 Nuvation Bio Inc. 1,8-naphthyridinone compounds and uses thereof
US11306071B2 (en) 2019-01-18 2022-04-19 Nuvation Bio Inc. Heterocyclic compounds as adenosine antagonists

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