AU2019323035B2 - Pyrazine compounds and uses thereof - Google Patents

Pyrazine compounds and uses thereof Download PDF

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Publication number
AU2019323035B2
AU2019323035B2 AU2019323035A AU2019323035A AU2019323035B2 AU 2019323035 B2 AU2019323035 B2 AU 2019323035B2 AU 2019323035 A AU2019323035 A AU 2019323035A AU 2019323035 A AU2019323035 A AU 2019323035A AU 2019323035 B2 AU2019323035 B2 AU 2019323035B2
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Prior art keywords
amino
pyrazine
methyl
carboxamide
pyridin
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AU2019323035A1 (en
Inventor
Changhe Qi
Honchung TSUI
Zhenfan YANG
Qingbei Zeng
Xiaolin Zhang
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Dizal Jiangsu Pharmaceutical Co Ltd
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Dizal Jiangsu Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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AU2019323035A 2018-08-17 2019-08-16 Pyrazine compounds and uses thereof Active AU2019323035B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2018/101006 2018-08-17
CN2018101006 2018-08-17
PCT/CN2019/100996 WO2020035052A1 (en) 2018-08-17 2019-08-16 Pyrazine compounds and uses thereof

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AU2019323035A1 AU2019323035A1 (en) 2021-02-18
AU2019323035B2 true AU2019323035B2 (en) 2024-11-07

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US (3) US10898481B2 (https=)
EP (1) EP3837250A4 (https=)
JP (1) JP7540996B2 (https=)
KR (1) KR102816365B1 (https=)
CN (1) CN112055709A (https=)
AR (1) AR115985A1 (https=)
AU (1) AU2019323035B2 (https=)
BR (1) BR112021002895A2 (https=)
CA (1) CA3107365A1 (https=)
MX (2) MX2021001884A (https=)
TW (1) TW202023559A (https=)
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WO2019018584A1 (en) 2017-07-18 2019-01-24 GiraFpharma LLC HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS
AU2019323035B2 (en) * 2018-08-17 2024-11-07 Dizal (Jiangsu) Pharmaceutical Co., Ltd. Pyrazine compounds and uses thereof
JP2022517418A (ja) * 2019-01-18 2022-03-08 ニューベイション・バイオ・インコーポレイテッド アデノシンアンタゴニストとしてのヘテロ環式化合物
EP3911323A4 (en) * 2019-01-18 2022-11-16 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS
EP3911324A4 (en) 2019-01-18 2022-08-17 Nuvation Bio Inc. 1,8-NAPHTHYRIDINONE COMPOUNDS AND THEIR USES
WO2021146629A1 (en) * 2020-01-17 2021-07-22 Nuvation Bio Inc. Heterocyclic compounds as adenosine antagonists
WO2021146631A1 (en) * 2020-01-17 2021-07-22 Nuvation Bio Inc. Heterocyclic compounds as adenosine antagonists
CA3182410A1 (en) 2020-05-04 2021-11-11 Volastra Therapeutics, Inc. Imino sulfanone inhibitors of enpp1
US12091412B2 (en) 2020-06-16 2024-09-17 Volastra Therapeutics, Inc. Heterocyclic inhibitors of ENPP1
KR102621694B1 (ko) * 2022-09-15 2024-01-08 주식회사 스탠다임 아데노신 a2a 수용체 길항제 및 이의 용도
US11987581B1 (en) 2023-12-19 2024-05-21 King Faisal University Imidazo[1,2-c]pyrido[3,4-e]pyrimidine-2-carboxylic acids as CK2 inhibitors
US11964974B1 (en) 2024-01-08 2024-04-23 King Faisal University Imidazo[1,2-c]pyrido[3,4-e]pyrimidine-3-carboxylic acids as CK2 inhibitors
WO2025191185A1 (en) * 2024-03-15 2025-09-18 Domain Therapeutics Azine-based compounds as par-2 inhibitors and therapeutic uses thereof

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