KR102816365B1 - 피라진 화합물 및 이의 용도 - Google Patents

피라진 화합물 및 이의 용도 Download PDF

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KR102816365B1
KR102816365B1 KR1020217007870A KR20217007870A KR102816365B1 KR 102816365 B1 KR102816365 B1 KR 102816365B1 KR 1020217007870 A KR1020217007870 A KR 1020217007870A KR 20217007870 A KR20217007870 A KR 20217007870A KR 102816365 B1 KR102816365 B1 KR 102816365B1
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amino
methyl
carboxamide
pyrazine
pyridin
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KR20210046714A (ko
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창헤 키
혼충 추이
킹베이 젱
젠판 양
시아올린 장
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디잘 (지앙수) 파마슈티칼 씨오., 리미티드
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Communicable Diseases (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020217007870A 2018-08-17 2019-08-16 피라진 화합물 및 이의 용도 Active KR102816365B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2018/101006 2018-08-17
CN2018101006 2018-08-17
PCT/CN2019/100996 WO2020035052A1 (en) 2018-08-17 2019-08-16 Pyrazine compounds and uses thereof

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KR20210046714A KR20210046714A (ko) 2021-04-28
KR102816365B1 true KR102816365B1 (ko) 2025-06-02

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US (3) US10898481B2 (https=)
EP (1) EP3837250A4 (https=)
JP (1) JP7540996B2 (https=)
KR (1) KR102816365B1 (https=)
CN (1) CN112055709A (https=)
AR (1) AR115985A1 (https=)
AU (1) AU2019323035B2 (https=)
BR (1) BR112021002895A2 (https=)
CA (1) CA3107365A1 (https=)
MX (2) MX2021001884A (https=)
TW (1) TW202023559A (https=)
WO (1) WO2020035052A1 (https=)

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WO2019018584A1 (en) 2017-07-18 2019-01-24 GiraFpharma LLC HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS
AU2019323035B2 (en) * 2018-08-17 2024-11-07 Dizal (Jiangsu) Pharmaceutical Co., Ltd. Pyrazine compounds and uses thereof
JP2022517418A (ja) * 2019-01-18 2022-03-08 ニューベイション・バイオ・インコーポレイテッド アデノシンアンタゴニストとしてのヘテロ環式化合物
EP3911323A4 (en) * 2019-01-18 2022-11-16 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS
EP3911324A4 (en) 2019-01-18 2022-08-17 Nuvation Bio Inc. 1,8-NAPHTHYRIDINONE COMPOUNDS AND THEIR USES
WO2021146629A1 (en) * 2020-01-17 2021-07-22 Nuvation Bio Inc. Heterocyclic compounds as adenosine antagonists
WO2021146631A1 (en) * 2020-01-17 2021-07-22 Nuvation Bio Inc. Heterocyclic compounds as adenosine antagonists
CA3182410A1 (en) 2020-05-04 2021-11-11 Volastra Therapeutics, Inc. Imino sulfanone inhibitors of enpp1
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