CN112044374A - Chip for chain polymerization based on microfluidic technology - Google Patents
Chip for chain polymerization based on microfluidic technology Download PDFInfo
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- CN112044374A CN112044374A CN202010902277.9A CN202010902277A CN112044374A CN 112044374 A CN112044374 A CN 112044374A CN 202010902277 A CN202010902277 A CN 202010902277A CN 112044374 A CN112044374 A CN 112044374A
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- chip
- chain polymerization
- test control
- air inlet
- main air
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0006—Controlling or regulating processes
- B01J19/0013—Controlling the temperature of the process
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
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- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The invention discloses a chip for chain type polymerization reaction based on a micro-fluidic technology, which relates to the technical field of chips and aims at solving the problems that the existing chip for chain type polymerization reaction has unreasonable structural design and no heat dissipation system. The invention has reasonable structural design and simple equipment, and can effectively solve the problem of heat dissipation of the chip main body and improve the service life and the working reliability of the chip by the structures of the main air inlet pipeline, the ventilation disc, the secondary ventilation pipeline, the main air outlet pipeline and the like.
Description
Technical Field
The invention relates to the technical field of chips, in particular to a chip for chain polymerization based on a microfluidic technology.
Background
Microfluidics refers to the science and technology involved in systems that process or manipulate tiny fluids using microchannels, and is an emerging interdiscipline that involves chemical, fluid physics, microelectronics, new materials, biology, and biomedical engineering. Because of their miniaturization, integration, etc., microfluidic devices are commonly referred to as microfluidic chips, also known as lab-on-a-chip and micro total analysis systems.
However, the existing chip for chain polymerization reaction has unreasonable structural design and no heat dissipation system, so that heat cannot be dissipated, the service life of the chip is prolonged, and the working reliability of the chip is reduced.
Disclosure of Invention
The chip for chain polymerization based on the microfluidic technology provided by the invention solves the problem of heat dissipation of the chip main body, and improves the service life and the working reliability of the chip.
In order to achieve the purpose, the invention adopts the following technical scheme:
the chip for the chain polymerization reaction based on the microfluidic technology comprises an upper substrate, wherein a chain polymerization reaction container based on the microfluidic technology is fixed on the upper array of the upper substrate, a lower substrate is fixedly connected to the lower side of the upper substrate, a chip main body is arranged inside the lower substrate, and a ventilation and heat dissipation mechanism used for dissipating heat and cooling the chip main body is arranged inside the lower substrate.
Preferably, ventilation cooling mechanism is including seting up left main intake stack on the infrabasal plate, a plurality of time air pipe have been seted up to main intake stack's both sides array, and a plurality of time air pipe keep away from the one end fixedly connected with ventilation dish of main intake stack, main air-out pipeline has been seted up on the right side of infrabasal plate, and main air-out pipeline switches on each other with main intake stack.
Preferably, a plurality of the vent disks are located right above the chip main body, and the vent disks press the chip main body.
Preferably, a temperature control unit, a signal sending unit, a signal receiving unit, a signal filtering unit, an automatic protection unit, an encryption circuit and a test control unit are arranged in the chip main body.
Preferably, the encryption circuit receives an input password from the outside, compares the received input password with a predetermined password, and outputs a test control signal to the test control unit according to the comparison result.
Preferably, the test control unit is an and gate, and is configured to receive the test control unit selection signal and the test control unit control signal, perform and operation on the received test control unit selection signal and the received test control unit control signal, and output the test signal to the corresponding test module.
Compared with the prior art, the invention has the beneficial effects that: according to the invention, the chain type polymerization reaction container, the upper substrate, the main air inlet pipeline, the lower substrate, the ventilation disc, the chip main body, the secondary ventilation pipeline, the main air outlet pipeline and other structures based on the microfluidic technology are arranged, so that the problem of heat dissipation of the chip main body can be effectively solved, and the service life and the working reliability of the chip are improved.
Drawings
FIG. 1 is a schematic perspective view of a chip for chain polymerization reaction based on microfluidic technology according to the present invention;
FIG. 2 is a schematic top view of a chip for chain polymerization reaction based on microfluidic technology according to the present invention;
FIG. 3 is a schematic top view of a ventilation and heat dissipation mechanism of a chip for chain polymerization reaction based on microfluidic technology according to the present invention;
FIG. 4 is a schematic diagram of a side view of a chip for chain polymerization reaction based on microfluidic technology according to the present invention.
In the figure: the device comprises a chain type polymerization reaction container based on the microfluidic technology, an upper substrate 2, a main air inlet pipeline 3, a lower substrate 4, a ventilation disc 5, a chip main body 6, a secondary ventilation pipeline 7 and a main air outlet pipeline 8.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Referring to fig. 1 to 4, a chip for chain polymerization based on a microfluidic technology includes an upper substrate 2, a chain polymerization container 1 based on a microfluidic technology is fixed in an array manner above the upper substrate 2, a lower substrate 4 is fixedly connected to a lower portion of the upper substrate 2, a chip main body 6 is arranged inside the lower substrate 4, and a ventilation and heat dissipation mechanism for dissipating heat and cooling the chip main body 6 is arranged inside the lower substrate 4.
In this embodiment, ventilation cooling mechanism is including seting up left main air inlet pipe 3 on the infrabasal plate, and a plurality of time air pipe 7 have been seted up to main air inlet pipe 3's both sides array, and a plurality of time air pipe 7 keep away from main air inlet pipe 3's one end fixedly connected with ventilation dish 5, and main air-out pipeline 8 has been seted up on the right side of infrabasal plate 4, and main air-out pipeline 8 switches on each other with main air inlet pipe 3.
In this embodiment, the plurality of vent disks 5 are located directly above the chip main body 6, and the vent disks 5 press the chip main body 6.
In this embodiment, a temperature control unit, a signal sending unit, a signal receiving unit, a signal filtering unit, an automatic protection unit, an encryption circuit, and a test control unit are disposed in the chip main body 6.
In this embodiment, the encryption circuit receives an input password from the outside, compares the received input password with a predetermined password, and outputs a test control signal to the test control circuit according to the comparison result.
In this embodiment, the test control unit is an and gate, and is configured to receive the test control unit selection signal and the test control signal, perform and operation on the received test module selection signal and test control signal, and output the test signal to the corresponding test module.
The theory of operation, at first, the heat that the reaction that takes place among the chain polymerization reaction container 1 based on micro-fluidic technology produced can transmit chip main part 6, make its temperature rise, then main intake stack 3 carries out the air inlet, loop through time air pipe 7, ventilation dish 5 reachs chip main part 6, cool down chip main part 6, then main air-out pipeline 8 carries out the air-out, realize the function of cooling, whole device reasonable in design, and the structure is ingenious, and convenient for operation can effectively solve the radiating problem of chip main part, the life and the operational reliability of chip are improved.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (6)
1. The utility model provides a chip for chain polymerization based on micro-fluidic technology, includes upper substrate (2), its characterized in that, the top array of upper substrate (2) is fixed with chain polymerization container (1) based on micro-fluidic technology, the below fixedly connected with infrabasal plate (4) of upper substrate (2), the inside of infrabasal plate (4) is equipped with chip main part (6), the inside of infrabasal plate (4) is equipped with and is used for the ventilation cooling mechanism for chip main part (6) heat dissipation cooling.
2. The chip for chain polymerization based on micro-fluidic technology of claim 1, wherein the ventilation and heat dissipation mechanism comprises a main air inlet pipeline (3) arranged on the left side of the lower substrate, a plurality of secondary air inlet pipelines (7) are arranged on the two sides of the main air inlet pipeline (3) in an array manner, a ventilation disc (5) is fixedly connected to one end of each secondary air inlet pipeline (7) far away from the main air inlet pipeline (3), a main air outlet pipeline (8) is arranged on the right side of the lower substrate (4), and the main air outlet pipeline (8) is communicated with the main air inlet pipeline (3).
3. A microfluidic chip for chain polymerization according to claim 2, wherein a plurality of vent discs (5) are located directly above the chip body (6), and the vent discs (5) press against the chip body (6).
4. The chip for chain polymerization based on microfluidic technology of claim 1, wherein the chip body (6) is internally provided with a temperature control unit, a signal sending unit, a signal receiving unit, a signal filtering unit, an automatic protection unit, an encryption circuit and a test control unit.
5. The chip for chain polymerization reaction based on microfluidic technology of claim 1, wherein the encryption circuit receives an input password from the outside, compares the received input password with a predetermined password, and outputs a test control signal to the test control circuit according to the comparison result.
6. The chip for chain polymerization based on microfluidic technology of claim 4, wherein the test control unit is an AND gate, and receives the test control unit selection signal and the test control signal, respectively, and ANDs the received test module selection signal and the test control signal to output the test signal to the corresponding test module.
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CN202010902277.9A CN112044374A (en) | 2020-09-01 | 2020-09-01 | Chip for chain polymerization based on microfluidic technology |
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CN202010902277.9A CN112044374A (en) | 2020-09-01 | 2020-09-01 | Chip for chain polymerization based on microfluidic technology |
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1963461A (en) * | 2006-11-21 | 2007-05-16 | 北京工业大学 | Lucifugal and radiating structure for testing PCR fluorescence of micro flow control biologic chip |
CN104375079A (en) * | 2014-11-07 | 2015-02-25 | 三星半导体(中国)研究开发有限公司 | Chip |
CN105263295A (en) * | 2015-10-21 | 2016-01-20 | 上海大学 | Micro channel radiator |
CN105296351A (en) * | 2015-12-02 | 2016-02-03 | 北京大学 | Chip for polymerase chain reaction (PCR), and real-time detection device and system |
CN110452814A (en) * | 2019-07-12 | 2019-11-15 | 北京资和源医疗科技有限公司 | A kind of PCR fast reaction chip |
CN110656801A (en) * | 2019-11-19 | 2020-01-07 | 中国建筑第七工程局有限公司 | Granary with ventilation system |
CN210058295U (en) * | 2019-04-25 | 2020-02-14 | 济南广音医疗科技有限公司 | Temperature control device based on micro-fluidic chip |
-
2020
- 2020-09-01 CN CN202010902277.9A patent/CN112044374A/en active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1963461A (en) * | 2006-11-21 | 2007-05-16 | 北京工业大学 | Lucifugal and radiating structure for testing PCR fluorescence of micro flow control biologic chip |
CN104375079A (en) * | 2014-11-07 | 2015-02-25 | 三星半导体(中国)研究开发有限公司 | Chip |
CN105263295A (en) * | 2015-10-21 | 2016-01-20 | 上海大学 | Micro channel radiator |
CN105296351A (en) * | 2015-12-02 | 2016-02-03 | 北京大学 | Chip for polymerase chain reaction (PCR), and real-time detection device and system |
CN210058295U (en) * | 2019-04-25 | 2020-02-14 | 济南广音医疗科技有限公司 | Temperature control device based on micro-fluidic chip |
CN110452814A (en) * | 2019-07-12 | 2019-11-15 | 北京资和源医疗科技有限公司 | A kind of PCR fast reaction chip |
CN110656801A (en) * | 2019-11-19 | 2020-01-07 | 中国建筑第七工程局有限公司 | Granary with ventilation system |
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Application publication date: 20201208 |