CN112043744A - 一种用于治疗鼻炎、鼻窦炎的外用药 - Google Patents
一种用于治疗鼻炎、鼻窦炎的外用药 Download PDFInfo
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Abstract
一种用于治疗鼻炎、鼻窦炎的外用药,属于外用药品,以甘遂、蟾蜍皮、细辛、白芷、硵砂、枯矾、煅牡蛎、金银花和甘草等中药材为原料,经过粉碎、调和等手段制备成为外用膏剂,对鼻炎、鼻窦炎以及由鼻炎、鼻窦炎引发的并发症进行治疗,使用简单,短时间起效,效果好,治愈率高,效果显著。
Description
技术领域
本发明涉及医疗药品技术领域,尤其是一种外用药品,具体是一种用于治疗鼻炎、鼻窦炎的外用药品。
背景技术
鼻炎即鼻腔炎性疾病,是病毒、细菌、变应原、各种理化因子以及某些全身性疾病引起的鼻腔黏膜的炎症,鼻炎的主要病理改变是鼻腔黏膜充血、肿胀、渗出、增生、萎缩或坏死等,而鼻窦炎则是一个或多个鼻窦发生炎症,这是一类在人群中发病率较高的疾病,影响患者的生活质量。部分鼻炎和鼻窦炎以难治著称,甚至有人将其视为终身复发疾病,虽然不直接危及人的生命,但其反复发作的症状及其长病程,常常严重影响人的生活、工作和交际,给患者带来诸多不便。
目前的治疗手段包括药物和手术,药物多选用“滴鼻净”、“鼻舒适”、“鼻炎康”等,然而,这些外用药物只能暂时缓解鼻塞症状,不能达到根治目的,并且其在缓解鼻塞的过程中促进鼻粘膜血管扩张,会进一步加重鼻塞,长期使用易形成药物性鼻炎,而内服药物经肠胃代谢吸收,流经全身才集中于病灶,药效甚微且有副作用。
最近用于临床的低温等离子系统消融术对鼻炎有明显效果,对鼻粘膜损伤小,无明显副作用,但价格昂贵是其缺点,且只针对各种类型的鼻炎导致的鼻腔阻塞有效,如过敏性鼻炎,慢性单纯性鼻炎,慢性肥厚性鼻炎以及其它类型的鼻炎,而对于鼻炎的其它症状无明显效果,或者无法控制其复发。一般外科手术尽管报道和广告宣传的非常有效,但手术的远期疗效名不理想,由于鼻腔组织的活性,术后切断的神经还会生长恢复,切除的下鼻甲也会继续生长,手术只能缓解症状而不能有效治愈。
因此,人们仍需求一种适合日常使用的能够缓解和治愈鼻炎、鼻窦炎的药物或治疗手段。
发明内容
为了解决现有技术的不足,本发明提出一种用于治疗鼻炎、鼻窦炎的外用药,使用简单,不用手术,不打针,不穿刺,无毒副作用,能够有效缓解和治疗急慢性鼻炎、肥厚性鼻炎、副鼻窦炎,且痊愈后不易复发。
本发明要解决的技术问题是通过以下技术方案实现的:
一种治疗鼻炎、鼻窦炎的外用药,其原料包括以下成分:甘遂、枯矾、金银花、细辛、白芷、蟾蜍皮、硵砂、冰片。
进一步的,其原料按照重量份数包括甘遂5-15份、枯矾5-10份、金银花10-20份、细辛10-20份、白芷10-20份、蟾蜍皮5-10份、硵砂10-20份、冰片5-10份,以及煅牡蛎0-20份、甘草0-10份、薄荷冰0-10份、麝香0-10份,辅料为麻油和凡士林。
进一步的,其原料按照重量份数包括甘遂5-15份、枯矾5-10份、金银花10-20份、细辛10-20份、白芷10-20份、蟾蜍皮5-10份、硵砂10-20份、冰片5-10份,以及煅牡蛎10-20份、甘草5-10份、薄荷冰3-10份、麝香5-10份,辅料为麻油和凡士林。
进一步的,甘遂、细辛、白芷、金银花、枯矾、硵砂、煅牡蛎、薄荷冰、冰片、麝香选用经过炮制的干燥药材,蟾蜍皮选用市售华蟾素片剂,甘草选用甘草提取物粉末。
进一步的,所述的治疗鼻炎、鼻窦炎的外用药的剂型为外用膏剂。
进一步的,所述治疗鼻炎、鼻窦炎的外用药的使用方法为使用推注器将膏剂推入鼻腔内适量,静候后自行清理鼻腔即可。
基于上述原料,所述的治疗鼻炎、鼻窦炎的外用药的制备方法包括以下步骤:
(1)选择药材,清理杂质和干燥,按照配方配比称量;
(2)把甘遂、细辛、白芷、金银花、枯矾、硵砂、煅牡蛎粉碎,过300目以上筛并混合均匀,蟾蜍皮单独粉碎过筛备用,薄荷冰、冰片和麝香粉碎过筛备用;
(3)准备蟾蜍皮、甘草提取物,以及薄荷冰、冰片、麝香、麻油和凡士林,把麻油加热融化凡士林后,将上步骤粉碎均匀的甘遂、细辛、白芷、金银花、枯矾、硵砂、煅牡蛎混合物细粉加入到麻油凡士林混合液中,趁热混匀,再加入蟾蜍皮粉末和甘草提取物粉末,混匀,最后加入薄荷冰、冰片和麝香并混匀,调成膏状;
(4)把上步骤制备的膏剂注入推注器中,用铝塑膜密封并辐照灭菌;
(5)产品装箱备用。
在本发明中,原料中的甘遂和蟾蜍皮为君药,细辛、白芷和硵砂为臣药,枯矾和煅牡蛎为佐药,金银花和甘草为使药。其中:
甘遂,味苦性寒,有小毒,入大肠、肺、肾经,用于泻水逐饮、消肿散结,具有通便、消毒、解肿的作用;
细辛,味辛性温,入肺、肾经,具有祛风散寒止痛、温肺化饮、宣通鼻窍的功效;
白芷,味辛性温,入肺、脾、胃经,具有祛风湿、活血排脓、生肌止痛的功效,用于治疗鼻塞、鼻渊;
金银花,味甘性寒,入肺、心、胃经,具有清热解毒、疏散风热的功效;
枯矾,性偏凉,有小毒,入肺、大肠经,具有消炎、燥湿、止血、止泻、解毒、杀虫、鼻衄、鼻息肉的功效;
硵砂,味咸、苦,性温,入肝、脾、胃经,具有消积软坚、化腐生肌、祛痰、利尿的功效,可用以息肉、赘疣;
煅牡蛎,味咸性寒,入肝、胆、肾经,具有收敛固涩、制酸止痛、镇安神软、软坚散结的功效;
蟾蜍皮,味辛性温,有毒,入心经,具有解毒、止痛、消肿、开窍醒神、抗过敏、增强机体免疫的功效;
甘草,味甘性平,入心、脾、肺、胃经,补脾益气、清热解毒、去痰止咳、缓急止痛、调和诸药;
薄荷冰,味辛性凉,入肺、肝经,发汗解热、疏肝理气、利咽止痛、止痒;
麝香,味辛性温,入心、脾经,开窍醒神,活血通经,消肿止痛;
冰片,味辛、苦,性微寒,入心、脾、肺经,开窍醒神,清热解毒,止痛。
在本发明中,蟾蜍皮优选以其提取物产品华蟾素入药,除具有明显抗肿瘤作用,还具有解毒、消肿、抑制病原微生物生长,增强机体免疫力的功效,华蟾素对尘螨所致的变应原过敏反应(超敏反应)有强效抑制作用,在过敏性鼻炎或哮喘的治疗上具有突出效果,且其为一种中药制剂,外用时对人体无任何毒副作用。
与现有技术相比,本发明具有以下优点:
产品使用简单,在家或在诊所单人即可操作使用,短时间起效,效果好,治愈率高;
原料简单易得,现有中西药房均有销售,获取方便简单;
产品加工过程简单,操作步骤少,产品易于制得;
原料各组分君臣佐使搭配合理,相互配合协作效果好,进一步提高药效。
具体实施方式
以下结合具体优选的实施例对本发明作进一步描述,但并不因此而限制本发明的保护范围。
一种用于治疗鼻炎、鼻窦炎的外用药,其原料按照以下重量份数进行配比:
实施例1
主料:甘遂12份、枯矾7份、金银花20份、细辛18份、白芷20份、蟾蜍皮8份、硵砂13份、冰片8份、煅牡蛎13份、甘草10份、薄荷冰4份、麝香6份;
辅料:麻油和凡士林适量。
实施例2
主料:甘遂10份、枯矾8份、金银花18份、细辛15份、白芷18份、蟾蜍皮7份、硵砂12份、冰片8份、煅牡蛎12份、甘草8份、薄荷冰3份;
辅料:麻油和凡士林适量。
实施例3
主料:甘遂8份、枯矾8份、金银花12份、细辛12份、白芷12份、蟾蜍皮5份、硵砂14份、冰片10份、煅牡蛎12份、麝香8份;
辅料:麻油和凡士林适量。
实施例4
主料:甘遂10份、枯矾10份、金银花15份、细辛16份、白芷15份、蟾蜍皮7份、硵砂20份、冰片7份、甘草7份、薄荷冰4份、麝香7份;
辅料:麻油和凡士林适量。
将上述各实施例的原料,按照以下步骤进行制备:
(1)选择药材,清理杂质和干燥,按照配方配比称量;
(2)把甘遂、细辛、白芷、金银花、枯矾、硵砂、煅牡蛎粉碎,过300目以上筛并混合均匀,蟾蜍皮单独粉碎过筛备用,薄荷冰、冰片和麝香粉碎过筛备用;
(3)准备蟾蜍皮、甘草提取物,以及薄荷冰、冰片、麝香、麻油和凡士林,把麻油加热融化凡士林后,将上步骤粉碎均匀的甘遂、细辛、白芷、金银花、枯矾、硵砂、煅牡蛎混合物细粉加入到麻油凡士林混合液中,趁热混匀,再加入蟾蜍皮粉末和甘草提取物粉末,混匀,最后加入薄荷冰、冰片和麝香并混匀,调成膏状;
(4)把上步骤制备的膏剂注入推注器中,用铝塑膜密封并辐照灭菌;
(5)产品装箱备用。
在上述步骤中,如果选择的配方中不包含某种原料,则跳过该原料,将其它原料按照上述步骤继续进行制备加工,直到制出产品。
经过临床试验,按照上述多种配比的原料和制备过程加工而成的产品的理化性质一致,使用效果近似,治疗效果近似。具体的临床试验案例包括:
李XX,女,15岁,某市高中学生。主诉:鼻塞,头痛流涕三年,经市医院诊断为:双侧下鼻甲3度肿大,建议手术。但患者不接受手术,患者寻医多处治疗效果不佳,与2020年4月8日来寻求诊疗,鼻腔内推注本申请所述的产品,静候40-60分钟后擤出,5天使用一次,共使用5次,已痊愈,随访至今未复发。
白XX,女,29岁,陕西西安人。主诉:鼻塞,头痛,流脓涕六年,在当地医院诊断为:慢性鼻甲肥大伴全组鼻窦炎。在当地寻医多处治疗无效,于2020年5月5日经患者介绍,让朋友代为寻求可使用7次的本申请所述的产品在家治疗,每次跟踪随访,共使用5次后痊愈,随访至今未复发。
胡XX,女,65岁。主诉:鼻塞,头痛,打喷嚏,流涕超过十年,在市医院诊断为:过敏性鼻炎,全组鼻窦炎,鼻息肉。患者不接受手术,于2019年1月8日来寻求诊疗,鼻腔内推注本申请所述的产品,静候40-60分钟后擤出,4次后,过敏性鼻炎症状缓解,息肉有大枣样脱落,鼻塞、头痛症状缓解,又使用3次后,又有几颗玉米粒大小息肉脱落,共7次痊愈,随访至今未复发。
谷XX,男,15岁。主诉:鼻塞,头痛伴发热一月余,在上级医院治疗效果不佳,仍发热。后查CT:全组鼻窦炎。经老患者介绍于2020年6月3日来寻求诊疗,推注使用本申请所述的产品,一次后没再发热,鼻塞、头痛减轻,共治疗6次痊愈,随访至今未复发。
程XX,女,38岁。主诉:鼻塞头痛,黄涕六个月余,市医院诊断为:慢性鼻甲肥大伴全组鼻窦炎,在别的诊所治疗三个月,已经花费三万多元,仍鼻塞、头痛。于2019年12月6日经亲戚介绍来寻求诊疗,患者鼻音重,痛苦面容,推注使用本申请所述的产品进入双鼻腔,静候60分钟后擤出,患者5天后进行第二次推注,来后述说在家擤出三颗花生米大小石头样硬物后,鼻塞、头痛消失,感觉治疗效果明显,心情舒畅,患者共使用5次后痊愈,随访至今未复发。
这些仅仅是几个典型案例,本申请所述的产品的实际治疗案例已治愈鼻炎、鼻窦炎患者数千例,不胜枚举,综合治疗显效率100%,治愈率95%以上。有效的实现了不用手术、不用打针、无痛苦的治疗,操作简单,时间短,见效快,治愈率高,使用简单方便快捷,效果显著。
Claims (7)
1.一种用于治疗鼻炎、鼻窦炎的外用药,其特征在于:其原料包括以下成分:甘遂、枯矾、金银花、细辛、白芷、蟾蜍皮、硵砂、冰片。
2.根据权利要求1所述的用于治疗鼻炎、鼻窦炎的外用药,其特征在于:其原料按照重量份数包括甘遂5-15份、枯矾5-10份、金银花10-20份、细辛10-20份、白芷10-20份、蟾蜍皮5-10份、硵砂10-20份、冰片5-10份,以及煅牡蛎0-20份、甘草0-10份、薄荷冰0-10份、麝香0-10份,辅料为麻油和凡士林。
3.根据权利要求2所述的用于治疗鼻炎、鼻窦炎的外用药,其特征在于:其原料按照重量份数包括甘遂5-15份、枯矾5-10份、金银花10-20份、细辛10-20份、白芷10-20份、蟾蜍皮5-10份、硵砂10-20份、冰片5-10份,以及煅牡蛎10-20份、甘草5-10份、薄荷冰3-10份、麝香5-10份,辅料为麻油和凡士林。
4.根据权利要求1-3任一所述的用于治疗鼻炎、鼻窦炎的外用药,其特征在于:甘遂、细辛、白芷、金银花、枯矾、硵砂、煅牡蛎、薄荷冰、冰片、麝香选用经过炮制的干燥药材,蟾蜍皮选用市售华蟾素片剂,甘草选用甘草提取物粉末。
5.根据权利要求4所述的用于治疗鼻炎、鼻窦炎的外用药,其特征在于:其剂型为外用膏剂。
6.根据权利要求4所述的用于治疗鼻炎、鼻窦炎的外用药,其特征在于:其使用方法为使用推注器将膏剂推入鼻腔内适量,静候后自行清理鼻腔即可。
7.根据权利要求4所述的用于治疗鼻炎、鼻窦炎的外用药,其特征在于:其制备方法包括以下步骤:
选择药材,清理杂质和干燥,按照配方配比称量;
把甘遂、细辛、白芷、金银花、枯矾、硵砂、煅牡蛎粉碎,过300目以上筛并混合均匀,蟾蜍皮单独粉碎过筛备用,薄荷冰、冰片和麝香粉碎过筛备用;
准备蟾蜍皮、甘草提取物,以及薄荷冰、冰片、麝香、麻油和凡士林,把麻油加热融化凡士林后,将上步骤粉碎均匀的甘遂、细辛、白芷、金银花、枯矾、硵砂、煅牡蛎混合物细粉加入到麻油凡士林混合液中,趁热混匀,再加入蟾蜍皮粉末和甘草提取物粉末,混匀,最后加入薄荷冰、冰片和麝香并混匀,调成膏状;
把上步骤制备的膏剂注入推注器中,用铝塑膜密封并辐照灭菌;
产品装箱备用。
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