CN115337368A - 一种治疗多种肛肠病的药物及其制备方法 - Google Patents
一种治疗多种肛肠病的药物及其制备方法 Download PDFInfo
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- CN115337368A CN115337368A CN202110538260.4A CN202110538260A CN115337368A CN 115337368 A CN115337368 A CN 115337368A CN 202110538260 A CN202110538260 A CN 202110538260A CN 115337368 A CN115337368 A CN 115337368A
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- Medicines Containing Plant Substances (AREA)
Abstract
一种治疗多种肛肠病的药物及其制备方法，它属于治疗多种肛肠病技术领域，它的组成分别为：人工麝香、人工牛黄、煅炉甘石、珍珠、冰片、氧化锌、藏红花、黄连、黄柏、苦参、百部、三七、凡士林、甘油、抑菌剂，醋酸氯已定和部分辅助料。把上述中药通过精选，部分药经过清洗、粉碎、煎煮等一系列工艺，在配制过程中一部分制成油相，一部分制成水相，把这两种半成品溶在一起就制成油包水的乳膏剂成品，用此配方还可以制成凝胶剂、散剂、外洗剂等，但都对治疗、痔疮、肛裂、肛周脓肿、肛门术后并发病、肛周湿疹和炎性外痔等多种疾病都有很好的治疗效果。
Description
技术领域：
本发明涉及一种治疗肛肠病的药物及其制备方法。这种特殊配方能够对多种肛肠疾病都有很好疗效。
背景技术
近年来我国的肛肠疾病发病率一直很高，这都是由于饮食及风、湿、燥、热、瘀为主要原因造成的，肛肠病给患者的生活和工作带来了极大的影响。本发明所提供的这个配方是根据中医理论结合自己多年临床经验，理论实践相结合的一种科学配方，再加上特殊制备工艺，提高了产品的疗效。用这个配方可制成乳膏剂、凝胶剂、散剂、外洗剂等，针对不同的肛肠病，选择适宜剂型，肛门湿疹等皮肤病用散剂、外洗剂。直肠有病用凝胶剂直肠注入。痔瘘外用敷抹药用膏剂，以便发挥其更好的治疗作用。
本发明的配方患处给药渗透力强，肛直肠里外兼治，直接作用于病灶，这样避免了口服药对肝肾体循环吸收的毒副作用。此方能收湿敛疮，祛腐生肌，抑菌止痒，清热解毒，消肿止痛，活血化瘀，效果显著。此方精选的药物是：人工麝香、人工牛黄、煅炉甘石、珍珠、冰片、氧化锌、藏红花、黄连、黄柏、苦参、百部、三七、醋酸氯己定；在制备乳膏剂过程中加辅料凡士林、甘油。
①本发明所精选的药物人工麝香，能开窍辟秽、活血散结，主治热病神昏、中风痰厥、惊痛、心腹暴痛、跌打疮疡、有消肿止痛、抗菌作用。
②本发明所精选的药物人工牛黄，味微苦，而后甜，性凉归肝心经可用于清热解毒，定惊安神，具有抗炎、抗病原微生物，抗氧化及抑制肿瘤生长的作用，外用对于创伤肿痛，有很好作用。
③本发明所精选的药物藏红花，性味甘平，能养血、补血具有降低血液粘稠度，扩张毛细血管，加快血流速度，舒经活络，促进血液循环，从而增强细胞免疫力，强身健体，延缓衰老的作用。
④本发明所精选的药物珍珠、味咸、甘寒、无毒，能镇心点目，镇静安神，解毒生肌，珍珠粉当中含有非常丰富的氨基酸，可有效提高人的免疫力，增强体质。
⑤本发明所精选的药物冰片味辛、苦、性寒，有开窍醒神，清热止痛的功效，对于喉咙肿痛、口腔溃疡、疮毒肿痛有很好作用。
⑥本发明所精选的药物煅炉甘石，通常用于皮肤用药，具有杀菌、收敛、消炎、止痒、保护伤口的作用，并能抑制局部葡萄球菌的生长，对于皮肤瘙痒、荨麻疹、亚急性湿疹有很好作用。
⑦本发明所精选的药物氧化锌，对于皮炎、湿疹、接触性皮炎都有很好的治疗作用。
⑧本发明所精选的药物三七，性微苦、味甘、归肝经、胃经。有化瘀止血、活血定痛的作用，活血化瘀功效明显，三七中含有人参三醇皂甙成份，能够兴奋大脑中枢，促进脑部血液循环，有很好的抗脑部疲劳作用。
⑨本发明所精选的药物黄连，味苦性寒，能清热燥湿，泻火解毒，黄连还可以有效抑制细菌，保护胃黏膜，同时具有抗炎镇痛作用。
⑩本发明所精选的药物黄柏，味苦、性寒、归肾经、膀胱经。具有清热燥湿、泻火除疮、解毒疗疮等功效，善于清泻肾脏虚火，可用于治疗阴虚火旺、疮疡肿毒，皮肤湿疹瘙痒不适等症。
(12)本发明所精选的药物百部，性味甘平，入肺经，其可以润肺止咳，用于肺阴不足或者肺津受伤引起的咳嗽，另外对于皮肤瘙痒、皮肤病变局部可以起到杀虫、散风、止痒作用。
(13)本发明所精选的药物凡士林，无刺激性，不易造成人体敏感，涂抹在皮肤上，使水分不易蒸发、散失，并且能阻挡来自空气中的细菌。使其成为油相膏制作基质。
(14)本发明所精选的药物甘油，无色，有治疗便秘，治疗皮肤皲裂的功效。使其成为水相膏基质。
(15)本发明所精选的原料，醋酸氯己定，本品具有消炎作用，对于各种皮肤及黏膜的消毒、创面感染都有很好的使用及防腐保质作用。
本发明所精选的配方，在制备乳膏剂以外的剂型产品中，如散剂、凝胶剂中不需要加甘油和凡士林。
本发明的科学配方精选道地名贵中草药和矿物药，对于多种肛肠疾病都有独特疗效，并且在制备工艺上也比较特殊，把这几味中药经过多道工序一系列工艺制成适宜剂型，才能得到疗效显著的成品，因此开发这种产品是很有必要的。
发明内容：
本发明的目的是提供一种治疗肛肠病的药物及其制备方法，这个配方制成膏剂等剂型涂抹在病灶上对于肛肠的多种疾病都有很好的治疗作用。
本发明解决其技术问题所采用的技术方案是：一种治疗肛肠病的药物及其制备方法的第一组药物组成分别为：人工麝香0.3～1g，人工牛黄1.5～3.5g，珍珠1～3g，冰片0.3～1g，煅炉甘石6～20g，氧化锌2～7g，第二组药物组成分别为：藏红花15-30g，黄连15-50g，黄柏 50～100g，苦参50～100g，百部50～100g，三七30～90g。
本制备乳膏剂过程中还要逐步加入凡士林、甘油、醋酸氯己定和部分其它辅助料。余量为净化水。(10日之用量)
优选比例为，第一组药物组成分别为：人工麝香0.6g，人工牛黄 2.5g，珍珠2g，冰片0.6g，煅炉甘石10g，氧化锌5g，第二组药物组成分别为：藏红花16g，黄连30g，黄柏80g，苦参80g，百部60g，三七50g；辅料为凡士林ng，甘油ng，醋酸氯己定ng和其它辅助料。余量为净化水。(10日之用量)
生产工艺为：
①取精选的第一组药物配方比例人工麝香0.3～1g，人工牛黄 1.5～3.5g，珍珠1～3g，冰片0.3～1g，煅炉甘石6～20g，氧化锌2～7g备用。
②把上述精选的原料进行粉碎，过290-300目筛。备用。
③取凡士林ng，用不锈钢容器加热50～80℃时，把上述搅拌均匀的药物细粉一并倒入再搅拌均匀，配制成油相浓缩液备用。
④取精选第二组药物配方比例，藏红花15-30g，黄连15-50g，黄柏50～100g，苦参50～100g，百部50～100g，三七30～90g，一并倒入纯净水中进行清洗干净后，再加兑总量8～10倍的水，并加热慢火煎煮 3～5小时，冷却后过滤浓缩得到活性物的混合静提液，加入甘油ng，混合均匀配制成水相混合溶液备用。
⑤把在④中制成水相活性混合溶液，加入到③的油相浓液中，再加入醋酸氯己定ng和微量辅料，同时加温至85℃，并搅拌均匀，使其乳化成乳霜状膏体，即成成品油包水的乳膏剂。
优选：一种治疗肛肠病的药物及其制备方法，其步骤如下：
①取精选的第一组药物按配方比例：人工麝香0.6g，人工牛黄2.5g，珍珠2g，冰片0.6g，煅炉甘石10g，氧化锌5g，备用。(10 日之用量)
②把精选的上述药物混合在一起粉碎过300目筛，备用。
③取凡士林ng，用不锈钢容器加热50～80℃时，把上述搅拌均匀的药物细粉一并倒入再搅拌均匀，配制成油相浓缩液备用。
④把精选的配方第二组药物按比例取藏红花16g，黄连30g，黄柏80g，苦参80g，百部60g，三七50g，一并倒入纯净水中进行清洗干净后，再加兑总量8～10倍的水，并加热慢火煎煮5小时，冷却后过滤浓缩得到活性物的混合静提液，再加入甘油ng，混合均匀配制成水相混合液备用。
⑤把在④中制成水相活性混合溶液，加入到③的油相浓液中，再加入醋酸氯己定ng和微量辅料，同时加温至85℃，并搅拌均匀，使其乳化成乳霜状膏体，即成成品油包水的乳膏剂。
本发明采用精选道地名贵中草药和矿物药及醋酸氯己定，加入辅料，经过加工熬制，分别制成油状物和水状活性混合溶液，再经过混合乳化就制成乳霜状膏剂，这样用起来不但方便，而且对于治疗多种肛肠疾病都有显著的疗效。
具体实施方式：
本发明具体实施方式的药物组成是，第一组药物组成分别为：人工麝香0.3～1g，人工牛黄1.5～3.5g，珍珠1～3g，冰片0.3～1g，煅炉甘石6～20g，氧化锌2～7g，第二组药物组成分别为：藏红花15-30g，黄连15-50g，黄柏50～100g，苦参50～100g，百部50～100g，三七30～90g。凡士林ng、甘油ng、醋酸氯己定ng，部分其它辅助料。余量为净化水。 (10日之用量)。优选比例为，第一组药物组成分别为：人工麝香0.6g，人工牛黄2.5g，，珍珠2g，冰片0.6g，煅炉甘石10g，氧化锌5g；第二组药物组成分别为：藏红花16g，黄连30g，黄柏80g，苦参80g，百部60g，三七50g，凡士林ng，甘油ng，醋酸氯己定ng和其它辅助料。余量为净化水。(10日之用量)
生产工艺为：
①取精选的药物比例为，第一组药物组成分别为：人工麝香 0.3～1g，人工牛黄1.5～3.5g，珍珠1～3g，冰片0.3～1g，煅炉甘石6～20g，氧化锌2～7g备用。
②把上述精选的原料进行混合粉碎，过290-300目筛。备用。
③取凡士林ng，用不锈钢容器加热50～80℃时，把上述搅拌均匀的药物细粉一并倒入再搅拌均匀，配制成油相浓缩液备用。
④取精选配方比例为，第二组药物组成分别为：藏红花15-30g，黄连15-50g，黄柏50～100g，苦参50～100g，百部50～100g，三七30～90g，一并倒入纯净水中进行清洗干净后，再加兑总量8～10 倍的水，并加热慢火煎煮3～5小时，冷却后过滤得到活性混合静提液，再加入甘油ng，混合均匀配制成水相混合液备用。
⑤把在④中制成水状活性混合溶液，加入到③的油状浓液中再加入醋酸氯己定ng和微量辅料，同时加温至85℃，并搅拌均匀，使其乳化成乳霜状膏体，即成成品油包水的乳膏剂。
优选：一种治疗肛肠病的药物及其制备方法，其步骤如下：
①取精选的药物比例为，第一组药物组成分别为：人工麝香 0.6g，人工牛黄2.5g，珍珠2g，冰片0.6g，煅炉甘石10g，氧化锌5g，醋酸氯己定ng和其它辅助料。余量为净化水。(10日之用量)
②把精选的上述药物混合在一起粉碎过300目筛，备用。
③取凡士林ng，用不锈钢容器加热50～80℃时，把上述搅拌均匀的药物细粉一并倒入再搅拌均匀，配制成油相浓缩液备用。
④把精选配方药物比例为，第二组药物组成分别为：取藏红花16g，黄连30g，黄柏80g，苦参80g，百部60g，三七50g，一并倒入纯净水中进行清洗干净后，再加兑总量10倍的水进行慢火煮5小时，冷却后过滤得到活性混合静提液，在这溶液中加入ng甘油并搅拌均匀，制成水相活性混合溶液备用。
⑤把在④中制成水相活性混合溶液，加入到③的油相状浓液中再加入醋酸氯己定ng和微量辅料，同时加温至85℃，并搅拌均匀，使其乳化成乳霜状膏体，即制成油包水的乳膏剂成品。
本发明精选道地名贵中草药和矿物药经过优选配方和制成适宜剂型，进一步加强了此配方的效力，作用更持久、疗效更好，对于痔疮、肛裂、肛周脓肿、肛周湿疹、肛门术后炎性和并发症都具有清热解毒、消肿止痛、祛风燥湿、抑菌止痒的疗效，这种药物可直达病灶，直接杀菌没有副作用，使用非常方便。这种外用肛肠药物直达患处给药，比口服药更有效果，且避免体内吸收和代谢的副作用，治疗痔瘘等肛肠病有显著疗效。需要注意的是，儿童和孕妇不可以使用，月经期间暂停用药，在使用时也忌食：辛、辣和酒。
显然本发明上述的实施例是为了清楚说明本发明举例，但本发明的保护范围并不局限于此乳膏剂，还可以用此配方制成凝胶剂、散剂、外洗剂，本发明可以有多种剂型用法变形和更改，凡在本发明的构思与原则之内所作的任何修改、改进和等同替换都应包含在本发明的保护范围之内。
Claims (4)
1.一种治疗多种肛肠病的药物及其制备方法，其特证在于由以下多种药物制成：第一组药物组成分别为：人工麝香0.3-1g，人工牛黄1.5-3.5g，珍珠1-3g，冰片0.3-1g，煅炉甘石6-20g，氧化锌2-7g。第二组药物组成分别为：藏红花15-30g，黄连15-50g，黄柏50-100g，苦参50-100g，百部50-100g，三七30-90g。凡士林ng，甘油ng，抑菌剂ng，醋酸氯己定ng和其它微量辅助料。余量为净化水。(10日之用量)。
2.按照权利要求1所述的一种治疗多种肛肠病的药物及其制备方法，其特征在于第一组药由以下药物原料组成，人工麝香0.6g，人工牛黄2.5g，珍珠2g，冰片0.6g，煅炉甘石10g，氧化锌5g。第二组药物组成分别为：藏红花16g，黄连30g，黄柏80g，苦参80g，百部60g，三七50g，凡士林ng，甘油ng，抑菌剂ng，醋酸氯己定ng和其它微量辅助料。余量为净化水。(10日之用量)。
3.一种如权利要求1所述的治疗多种肛肠病的药物及其制备方法，其特征在于步骤如下：
生产工艺为：
①取精选的第一组药物人工麝香0.3-1g，人工牛黄1.5-3.5g，珍珠1-3g，冰片0.3-1g，煅炉甘石6-20g，氧化锌2-7g备用。
②把精选的上述原料进行混合粉碎，过250-300目筛。备用。
③取凡士林ng，用不锈钢容器加热50-80℃时，把上述搅拌均匀的药物细粉一并倒入再搅拌均匀，配制成油相浓缩液。备用。
④把精选的第三组药物配方比例藏红花15-30g，黄连15-50g，黄柏50-100g，苦参50-100g，百部50-100g，三七30-90g，一并倒入纯净水中进行清洗干净后，再加入总量8-10倍的水，并加热慢火煎煮3-5小时，冷却后过滤得到活性混合静提溶液，在静提液中加入n克甘油，搅拌均匀，制成水相活性混合溶液。备用
⑤把在④中制成水状活性混合溶液，加入到③的油状浓液中再加入抑菌剂ng，醋酸氯己定ng微量辅料，同时加温至85℃，并搅拌均匀，使其乳化成乳霜状膏体，即成成品油包水的乳膏剂。
4.一种如权利要求2所述的治疗多种肛肠病的药物及其制备方法，其特征在于步骤如下：
①取精选的第一组药物人工麝香0.6g，人工牛黄2.5g，珍珠2g，冰片0.6g，煅炉甘石10g，氧化锌5g备用。
②把精选的上述原料进行混合粉碎，过300目筛。备用。
③取凡士林ng，用不锈钢容器加热100℃时，把上述搅拌均匀的药物细粉一并倒入再搅拌均匀，配制成油相浓缩液。备用。
④把精选的第三组药物配方比例藏红花16g，黄连30g，黄柏80g，苦参80g，百部60g，三七50g，一并倒入纯净水中进行清洗干净后，再加入总量10倍的水，并加热慢火煎煮5小时，冷却后过滤得到活性混合静提溶液，在静提液中加入n克甘油，搅拌均匀，制成水相活性混合溶液。备用
⑤把在④中制成水状活性混合溶液，加入到③的油状浓液中再加入抑菌剂ng，醋酸氯己定ng微量辅料，同时加温至100℃，并搅拌均匀，使其乳化成乳霜状膏体，即成成品油包水的乳膏剂。
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