CN111991443A - Traditional Chinese medicine oral ulcer ointment and preparation method thereof - Google Patents
Traditional Chinese medicine oral ulcer ointment and preparation method thereof Download PDFInfo
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- 239000002674 ointment Substances 0.000 title abstract description 8
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine oral ulcer ointment, which belongs to the technical field of traditional Chinese medicines and natural medicines and is prepared from the following substances: sedum sarmentosum, fructus Toosendan, and flos Bombacis Malabarici. The method has simple process, is beneficial to commercial manufacture and application, and the prepared oral ulcer paste can quickly relieve and treat oral ulcer symptoms, has quick effect and no toxic or side effect, can safely and effectively accelerate the healing of ulcer surfaces and shorten the course of disease, and is suitable for being used when the oral ulcer symptoms appear and preventing and using in daily life.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines and natural medicines, and particularly relates to a traditional Chinese medicine oral ulcer paste and a preparation method thereof.
Background
The throat is an important immune organ of a human body, and a plurality of infectious diseases and immune diseases are closely related to the throat, such as pharyngolaryngitis, acute and chronic tonsillitis and the like. The pharyngolaryngitis is a common and frequently encountered disease in clinic and is classified into acute and chronic diseases. The patients often feel sore throat during attack, and the symptoms of the patients are accompanied by obstruction of the peduncle, uncomfortable pharynx, lack of pronunciation, dry throat, frequent drinking or foreign body sensation in the pharynx and the like, belong to the field of throat impediment in traditional Chinese medicine, and the traditional Chinese medicine and western medicine for treating the throat impediment in the market at present have poor effects.
The mouth, an important organ connected to the throat, is also the origin of many diseases. Among them, recurrent oral ulcer, also called recurrent aphtha and afurt stomatitis, is a stubborn chronic stomatitis with recurrent symptoms of small and painful ulcer of oral mucosa. Most of the oral ulcers occur in the mucous membrane areas which are easy to move in the oral cavity, and often cause patients to feel hard to endure and sleep and eat. Epidemiological investigations have shown that at least 1 ulcer occurs in 1 out of every 5 persons, and that it occurs in both men and women, at all ages, and in all races. Moreover, the oral ulcer of many patients often recurs, and the patients are good and bad, so that diet and daily life are affected, the patients are seriously troubled, and even the mood of the patients is affected.
At present, the etiology and pathogenic mechanism of recurrent oral ulcer are still unclear, and because the etiology is unclear, the diagnosis of recurrent oral ulcer is completely based on the medical history and clinical manifestations, and laboratory indexes which can be used as the basis for definite diagnosis are lacked. From a western medicine perspective, recurrent oral ulceration predicts that the patient's body may have underlying systemic diseases, such as those of the gastrointestinal, blood and endocrine systems, but clinically most patients are healthy and have no systemic disease. From the perspective of traditional Chinese medicine, it is considered that the external causes are mainly heat-toxicity, while the internal causes are mostly emotional internal injuries, improper diet and labourious atrioventricular diseases. However, because the etiology and pathogenesis of oral ulcer are very complicated, the diagnosis can only be established on the basis of the symptomatology, and a unified diagnosis standard is also lacked.
In the actual diagnosis and treatment process, the tin powder is commonly used for treating laryngopathy and recurrent oral ulcer, is used for treating sore throat erosion and swelling, has the efficacy of detoxifying and removing putrefaction, and has poor actual clinical curative effect. Yangyi Fang (Yangyi Fang, Guqing, Wanlihua, Guogu, Wangxi, and Zangjiang. Gushi throat Bixue powder for local external application for treating recurrent oral ulcer 58 cases [ J]Journal of Shanghai medicine 2012, 12 (46): 51-52) the Bixue powder is used for treatment, has the effects of clearing heat and removing toxicity, relieving swelling and pain, healing sore and promoting granulation, and can be used for treating recurrent oral ulcer, sore throat, acute and chronic tonsillitis and the like, wherein in 58 cases of oral ulcer, the total effective rate is 98.2 percent and is obviously higher than 86.0 percent of the tin powder group. However, Bixue powder contains trace amount of cinnabar, realgar, Liangaihua, etcStudy of the accumulation of mercurous cinnabarinus in rats, Lichung, Schopper, etc. [ J ]]Chinese traditional medicine journal, 2009, 34 (23): 3068 + 3072) it is found that the main component of cinnabar is mercuric sulfide (HgS), which can be converted into mercury after heating, and the soluble mercury of cinnabar can be absorbed into human body, and after long-term administration, the mercury can be accumulated in kidney, brain and liver tissues, wherein the mercury accumulation of kidney is maximum. Meanwhile, Realgar contains As As main ingredient2S2After heated to a certain temperature, arsenic trioxide can be oxidized in the air to be a highly toxic component, namely arsenic trioxide, which may cause poisoning.
Therefore, although modern medical drug therapy has a certain curative effect, the problems of potential risks, narrow application range and the like still exist. Therefore, there is a need to continuously try to develop new drugs for treating oral and throat diseases with significant efficacy, wider application range and less side effects.
More and more researchers have turned their eyes to the herbal ingredients, such as the following: 201410369146.3 discloses a Chinese medicinal composition for treating recurrent oral ulcer, which is prepared from the following raw materials (by weight portion): 12-20 parts of gypsum, 6-12 parts of coptis chinensis, 9-15 parts of scutellaria baicalensis, 6-12 parts of radix puerariae, 9-15 parts of olive, 9-15 parts of rose root, 6-12 parts of immature bitter orange, 3-9 parts of liquorice, 9-15 parts of prepared rehmannia root, 6-12 parts of pinellia ternate, 6-12 parts of radix bupleuri and 6-12 parts of white paeony root. Although the traditional Chinese medicine has a good healing effect, the used components are more, so that the manufacturing cost is increased, on the other hand, the Chinese herbal medicine still contains a plurality of unidentified components, and the risk of toxin deposition in vivo is increased due to the use of excessive types. In addition, the traditional Chinese medicine composition still has certain space for improvement in effect.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine oral ulcer ointment.
The technical purpose of the invention is realized by the following technical scheme:
a traditional Chinese medicine oral ulcer paste is prepared from the following substances in parts by weight:
14-20 parts of sedum sarmentosum, 30-40 parts of szechwan chinaberry fruit and 6-12 parts of kapok.
Preferably, the food is prepared from the following substances in parts by weight:
16-18 parts of sedum sarmentosum, 33-37 parts of szechwan chinaberry fruit and 8-10 parts of kapok.
More preferably, the food additive is prepared from the following substances in parts by weight:
17 parts of sedum sarmentosum, 35 parts of szechwan chinaberry fruit and 9 parts of kapok.
The second purpose of the invention is to provide a preparation method of the traditional Chinese medicine oral ulcer paste.
The technical purpose of the invention is realized by the following technical scheme:
a preparation method of a traditional Chinese medicine oral ulcer paste comprises the following steps:
mixing the sedum sarmentosum, the szechwan chinaberry fruit and the kapok, adding clear water with the total mass being 8-10 times of that of the sedum sarmentosum, heating, boiling for 1.5-2 hours, filtering, and finally heating and concentrating the filtrate to form a paste.
Preferably, the method comprises the following steps:
(1) mixing the sedum sarmentosum, the szechwan chinaberry fruit and the kapok, then putting into a frying pan for frying, and taking out for later use after 30-35 min;
(2) mixing the sedum sarmentosum, the szechwan chinaberry fruit and the kapok with clear water which is 8-10 times of the total mass of the sedum sarmentosum, the szechwan chinaberry fruit and the kapok, heating, boiling, treating for 1.5-2 hours, filtering, and finally heating and concentrating the filtrate to form a paste.
Further, the temperature in the frying pan is controlled to be 90-95 ℃ during the frying control treatment in the step (1).
Further, the temperature during heating and concentration in the step (2) is controlled to be 80-85 ℃.
More preferably, the method comprises the following steps:
(1) mixing the sedum sarmentosum, the szechwan chinaberry fruit and the kapok, then putting into a marmite containing wheat bran for stir-frying, and taking out for later use after 30-35 min;
(2) mixing the sedum sarmentosum, the szechwan chinaberry fruit and the kapok with clear water which is 8-10 times of the total mass of the sedum sarmentosum, the szechwan chinaberry fruit and the kapok, heating, boiling, treating for 1.5-2 hours, filtering, and finally heating and concentrating the filtrate to form a paste.
Further, the temperature in the frying pan is controlled to be 110-115 ℃ during the frying control treatment in the step (1).
Further, the pressure of the environment is controlled to be 200-300 Pa and the temperature is controlled to be 60-65 ℃ during heating and concentrating in the step (2).
Sedum sarmentosum Bunge is a perennial herbaceous succulent plant of Crassulaceae. Thin flower stem, creeping, root growing on the node, growing impeller, turning leaf into needle shape to long circle, collecting the inflorescence, little flower and no peduncle; sepals are coated with needles to be long round, petals are yellow, needles to be long round, scales are wedge-shaped and square, seeds are oval, blossoming occurs in 5-7 months, and fruiting occurs in 8 months. Sedum sarmentosum generally grows in rock gaps of hillsides, ditch sides and wet river sides, is easy to cultivate and has low requirements on the environment, can be planted in front of and behind houses, can be potted, and is usually propagated by dividing plants. The whole herb is used as a medicine, has cool property, sweet, light and slightly sour taste, and has the effects of clearing heat and removing toxicity and the like.
Chuan Lian Zi, name of Chinese traditional medicine. Is dried mature fruit of Melia toosendan Sieb. Is spherical-like and has a diameter of 2-3.2 cm. The surface is golden yellow to brownish yellow, slightly lustrous, slightly concave or shrivelled and has dark brown dots. The top has the stump mark, the base is concave, and there is the fruit stalk mark. The exocarp leather is often in a gap with the pulp, and the pulp is soft and light yellow and shows viscosity when being wetted by water. The fruit stone is spherical or oval, hard in texture, truncated at two ends, and provided with 6-8 longitudinal edges, the interior of the fruit stone is divided into 6-8 chambers, and each chamber contains 1 black-brown oblong seed. Special smell, sour and bitter taste. Bitter and cold in nature. Has the effects of soothing liver, clearing heat, promoting qi circulation, relieving pain, resisting bacteria, killing parasites and the like.
Kapok is a flower tissue of kapok, can be used as a medicine, mainly contains chemical components such as flavonoids, organic acids, steroids, triterpenes, coumarins and the like, and has the effects of detoxifying, clearing heat, dispelling cold, removing dampness, cooling blood, stopping bleeding, moistening lung, relieving cough and the like.
The three components used in the invention have good medicinal value, the raw materials are easy to obtain, the cost is low, and the three components are rarely used for treating the dental ulcer.
Compared with the prior art, the invention has the following advantages:
the oral ulcer paste provided by the invention is reasonably matched with three components of sedum sarmentosum, szechwan chinaberry fruit and kapok, and is used as an effective component for relieving and preventing oral ulcer symptoms, the three components are mutually cooperated to enhance the overall drug effect, so that the oral ulcer symptoms can be quickly relieved and treated, and the oral ulcer paste is low in cost and high in use safety. The method has simple process, is beneficial to commercial manufacture and application, and the prepared oral ulcer paste can quickly relieve and treat oral ulcer symptoms, has quick effect and no toxic or side effect, can safely and effectively accelerate the healing of ulcer surfaces and shorten the course of disease, is suitable for being used when the oral ulcer symptoms appear and also being used for preventing in daily life, and has great market competitiveness.
Detailed Description
Example 1
A traditional Chinese medicine oral ulcer paste is prepared from the following substances in parts by weight:
example 2
A traditional Chinese medicine oral ulcer paste is prepared from the following substances in parts by weight:
| composition of matter | Parts by weight (parts) |
| Herba Sedi | 16 |
| Fructus Toosendan | 33 |
| Kapok | 8 |
Example 3
A traditional Chinese medicine oral ulcer paste is prepared from the following substances in parts by weight:
| composition of matter | Parts by weight (parts) |
| Herba Sedi | 17 |
| Fructus Toosendan | 35 |
| Kapok | 9 |
Example 4
A traditional Chinese medicine oral ulcer paste is prepared from the following substances in parts by weight:
| composition of matter | Parts by weight (parts) |
| Herba Sedi | 18 |
| Fructus Toosendan | 37 |
| Kapok | 10 |
Example 5
A traditional Chinese medicine oral ulcer paste is prepared from the following substances in parts by weight:
| composition of matter | Parts by weight (parts) |
| Herba Sedi | 20 |
| Fructus Toosendan | 40 |
| Kapok | 12 |
Comparative example 1
A traditional Chinese medicine oral ulcer paste is prepared from the following substances in parts by weight:
| composition of matter | Parts by weight (parts) |
| Fructus Toosendan | 35 |
| Kapok | 9 |
This comparative example 1 is compared to example 3 with the only difference that the use of the sedum sarmentosum component is omitted except that the process steps are otherwise the same.
Comparative example 2
A traditional Chinese medicine oral ulcer paste is prepared from the following substances in parts by weight:
| composition of matter | Parts by weight (parts) |
| Herba Sedi | 17 |
| Kapok | 9 |
This comparative example 1 is different from example 3 only in that the use of the toosendan fruit component is omitted, except that the process steps are the same.
Comparative example 3
A traditional Chinese medicine oral ulcer paste is prepared from the following substances in parts by weight:
| composition of matter | Parts by weight (parts) |
| Herba Sedi | 17 |
| Fructus Toosendan | 35 |
This comparative example 3 is compared to example 3 with the only difference that the use of kapok components is omitted except that the process steps are otherwise identical.
Comparative example 4
A traditional Chinese medicine oral ulcer paste is prepared from the following substances in parts by weight:
| composition of matter | Parts by weight (parts) |
| Fructus Toosendan | 35 |
This comparative example 4 is compared to example 3 only with the difference that the use of the sedum sarmentosum and kapok components is omitted except that the process steps are otherwise identical.
Comparative example 5
The application numbers are: 201410369146.3 discloses a Chinese medicinal composition for treating recurrent oral ulceration, which adopts the technical scheme of the embodiment 3.
Example 6
A preparation method of a traditional Chinese medicine oral ulcer paste comprises the following steps:
mixing herba Sedi, fructus Toosendan and flos Bombacis Malabarici, adding clear water 8 times of the total weight, boiling for 1.5 hr, filtering, and heating and concentrating the filtrate to obtain paste.
Example 7
A preparation method of a traditional Chinese medicine oral ulcer paste comprises the following steps:
mixing herba Sedi, fructus Toosendan and flos Bombacis Malabarici, adding 10 times of clear water, boiling for 2 hr, filtering, and concentrating the filtrate to obtain paste.
Example 8
A preparation method of a traditional Chinese medicine oral ulcer paste comprises the following steps:
(1) mixing herba Sedi, fructus Toosendan and flos Bombacis Malabarici together, and parching in a frying pan at 90 deg.C for 30 min;
(2) mixing the sedum sarmentosum, the szechwan chinaberry fruit and the kapok with clear water which is 8 times of the total mass of the sedum sarmentosum, the szechwan chinaberry fruit and the kapok, boiling for 1.5 hours, filtering, and finally heating and concentrating the filtrate to paste, wherein the temperature during heating and concentrating is controlled to be 80 ℃.
Example 9
A preparation method of a traditional Chinese medicine oral ulcer paste comprises the following steps:
(1) mixing herba Sedi, fructus Toosendan and flos Bombacis Malabarici together, and parching in a frying pan at 95 deg.C for 35 min;
(2) mixing the sedum sarmentosum, the szechwan chinaberry fruit and the kapok with clear water which is 10 times of the total mass of the sedum sarmentosum, the szechwan chinaberry fruit and the kapok, heating, boiling and boiling for 2 hours, filtering, and finally heating and concentrating the filtrate to paste, wherein the temperature during heating and concentrating is controlled to be 85 ℃.
Example 10
A preparation method of a traditional Chinese medicine oral ulcer paste comprises the following steps:
(1) mixing herba Sedi, fructus Toosendan and flos Bombacis Malabarici, parching in casserole containing testa Tritici at 110 deg.C for 30min, and taking out;
(2) mixing the sedum sarmentosum, the szechwan chinaberry fruit and the kapok with clear water which is 8 times of the total mass of the sedum sarmentosum, the szechwan chinaberry fruit and the kapok, heating, boiling and boiling for 1.5 hours, filtering, and finally heating and concentrating the filtrate to paste, wherein the air pressure of the environment is controlled to be 200Pa and the temperature is controlled to be 60 ℃ during heating and concentrating.
Example 11
A preparation method of a traditional Chinese medicine oral ulcer paste comprises the following steps:
(1) mixing herba Sedi, fructus Toosendan and flos Bombacis Malabarici, parching in casserole containing testa Tritici at 115 deg.C for 35min, and taking out;
(2) mixing the sedum sarmentosum, the szechwan chinaberry fruit and the kapok with clear water which is 10 times of the total mass of the sedum sarmentosum, the szechwan chinaberry fruit and the kapok, heating, boiling and boiling for 2 hours, filtering, and finally heating and concentrating the filtrate to paste, wherein the air pressure of the environment is controlled to be 300Pa and the temperature is 65 ℃ during heating and concentrating.
In order to compare the effects of the present invention, the oral ulcer pastes corresponding to the above examples 3 and comparative examples 1 to 5 were subjected to performance tests, wherein the preparation methods corresponding to the examples 3 and comparative examples 1 to 4 all adopt the scheme of example 8.
Experiment one: in vitro antibacterial test
In recent years, several scholars have found that helicobacter pylori is closely related to oral ulcer, and the relevance is also summarized in chinese patent 201310521843.1: helicobacter pylori is an important flora causing dental ulcer, and inhibition of helicobacter pylori is effective in alleviating the disease. The bacteriostatic test of helicobacter pylori is carried out according to the conventional bacteriostatic test method, and the specific comparative data are shown in the following table 1:
TABLE 1
| Helicobacter pylori inhibitory rate (%) | |
| Example 3 | 99.80 |
| Comparative example 1 | 88.25 |
| Comparative example 2 | 78.91 |
| Comparative example 3 | 92.04 |
| Comparative example 4 | 82.73 |
| Comparative example 5 | 97.56 |
As can be seen from the above Table 1, the inventive oral ulcer paste has a strong inhibitory effect on helicobacter pylori.
Experiment two: in vivo therapeutic test
180 patients are selected for clinical test, before treatment, the patients have repeated attack history of the oral ulcer, the attack is different for 1-3 days, the pain is obvious, the wound and the swelling of the oral cavity and the throat are red, and serious patients can be accompanied by a small amount of inflammatory secretion. Patients were divided into 6 groups at random, the drugs corresponding to the above example 3 and comparative examples 1 to 5 were treated, and then the effect of treatment was evaluated by the traditional Chinese medicine syndrome improvement rate (nimodipine method), with the following specific formula: the traditional Chinese medicine evidence-waiting improvement rate (nimodipine method) ═ integration before treatment-integration after treatment)/integration before treatment ] × 100%;
the score before and after treatment is measured by mainly 3 values:
(1) total number of ulcers (N): the total number of ulcers appeared within 72 hours of onset. The number of the ulcers is 1-2, and the score is 1; 3-4, 2 points are counted; 5 or more, 3 points.
(2) Ulcer area (S): selecting the most obvious ulcer with the largest or symptom in the mouth within 72 hours and recording the location of the ulcer in the mouth (calculated as the product of the maximum diameter of the ulcer and its vertical diameter, in mm)2Calculated area) ulcer area<5mm2Marking as 1 point; 5-10mm2Marking as 3 points;>10mm2and the score is 5.
(3) Pain due to ulcer: ulcer irritation pain (pain caused by tapping the center of the ulcer surface with the tip side of the periodontal probe, affected part) was recorded in ulcer patients using Visual Analogue Scale (VAS). Specifically, a pain index (P) is adopted, namely a visual analog scale is used for recording the pain score of the ulcer every day, wherein a straight line of 10cm is adopted, the 0 end of the straight line represents 'no pain', the 10cm end represents 'most severe pain', patients make records on the response scale of the straight line according to different pain sensation degrees, and the records are recorded for 1 time at each double-diagnosis.
The treatment effect is divided into the following indexes according to the integral size:
(A) and (3) curing: the clinical symptoms and pain basically disappear, and the eating is not influenced. The integral of improving symptoms and signs is more than or equal to 95 percent.
(B) The effect is shown: the clinical symptoms and pain are obviously improved, only mild symptoms appear, the food intake is not affected, or the disease condition is changed from severe to mild. The score for improvement in symptoms and pain ranged between 70-94%.
(C) The method has the following advantages: clinical symptoms, pain, were reduced or improved, but the disease was unstable, relapsed but not aggravated, and had an effect on food intake. The score for improvement in symptoms and pain ranged between 30-69%.
(D) And (4) invalidation: the effective standard is not reached. The integral of improvement of symptoms and pains is less than 30%.
And calculating the cure rate and the total effective rate of the treatment effect according to the treatment effect index, wherein the specific calculation formula of the cure rate and the total effective rate is as follows:
the cure rate is [ (clinical cure number + significant effect number)/total number ] × 100%;
the total effective rate is [ (clinical cure number + significant number + effective number)/total number ] × 100%.
Comparative data for the above experiments are shown in table 2 below:
TABLE 2
As can be seen from the above table 2, the healing effect of the oral ulcer ointment is remarkably enhanced, and the oral ulcer ointment has great popularization and application values.
In order to further compare the treatment effect of the method of the present invention, the raw material formula of example 5 is selected, and then the oral ulcer ointments are prepared by the methods of examples 6 to 11, wherein the oral ulcer ointments are marked as A5B6, A5B7, A5B8, A5B9, A5B10 and A5B11, and then the in vitro antibacterial test of the first experiment is repeated, and the specific comparison data are shown in table 3 below:
TABLE 3
| Helicobacter pylori inhibitory rate (%) | |
| A5B6 | 96.32 |
| A5B7 | 97.01 |
| A5B8 | 99.70 |
| A5B9 | 99.81 |
| A5B10 | 99.92 |
| A5B11 | 99.96 |
As can be seen from the above Table 3, the plasters prepared by the different preparation methods of the present invention have different use effects, and the method of examples 8 to 11 can be selected to process and prepare the plasters in order to improve the use quality of the raw materials.
Claims (10)
1. The traditional Chinese medicine oral ulcer paste is characterized by being prepared from the following substances in parts by weight:
14-20 parts of sedum sarmentosum, 30-40 parts of szechwan chinaberry fruit and 6-12 parts of kapok.
2. The traditional Chinese medicine oral ulcer paste as claimed in claim 1, which is prepared from the following substances in parts by weight:
16-18 parts of sedum sarmentosum, 33-37 parts of szechwan chinaberry fruit and 8-10 parts of kapok.
3. The traditional Chinese medicine oral ulcer paste as claimed in claim 2, which is prepared from the following substances in parts by weight:
17 parts of sedum sarmentosum, 35 parts of szechwan chinaberry fruit and 9 parts of kapok.
4. A method for preparing the traditional Chinese medicine oral ulcer paste as claimed in any one of claims 1 to 3, which is characterized by comprising the following steps:
mixing the sedum sarmentosum, the szechwan chinaberry fruit and the kapok, adding clear water with the total mass being 8-10 times of that of the sedum sarmentosum, heating, boiling for 1.5-2 hours, filtering, and finally heating and concentrating the filtrate to form a paste.
5. The preparation method of the traditional Chinese medicine oral ulcer paste as claimed in claim 4, which is characterized by comprising the following steps:
(1) mixing the sedum sarmentosum, the szechwan chinaberry fruit and the kapok, then putting into a frying pan for frying, and taking out for later use after 30-35 min;
(2) mixing the sedum sarmentosum, the szechwan chinaberry fruit and the kapok with clear water which is 8-10 times of the total mass of the sedum sarmentosum, the szechwan chinaberry fruit and the kapok, heating, boiling, treating for 1.5-2 hours, filtering, and finally heating and concentrating the filtrate to form a paste.
6. The method for preparing a traditional Chinese medicine oral ulcer paste as claimed in claim 5, wherein the temperature in the frying pan is controlled to be 90-95 ℃ during the frying treatment in the step (1).
7. The method for preparing a Chinese medicinal oral ulcer paste according to claim 5, wherein the temperature during the heating and concentrating in the step (2) is controlled to be 80-85 ℃.
8. The preparation method of the traditional Chinese medicine oral ulcer paste as claimed in claim 5, which is characterized by comprising the following steps:
(1) mixing the sedum sarmentosum, the szechwan chinaberry fruit and the kapok, then putting into a marmite containing wheat bran for stir-frying, and taking out for later use after 30-35 min;
(2) mixing the sedum sarmentosum, the szechwan chinaberry fruit and the kapok with clear water which is 8-10 times of the total mass of the sedum sarmentosum, the szechwan chinaberry fruit and the kapok, heating, boiling, treating for 1.5-2 hours, filtering, and finally heating and concentrating the filtrate to form a paste.
9. The method for preparing a traditional Chinese medicine oral ulcer paste as claimed in claim 8, wherein the temperature in the frying pan is controlled to be 110-115 ℃ during the frying treatment in the step (1).
10. The method for preparing a Chinese medicinal oral ulcer paste according to claim 8, wherein the atmospheric pressure of the environment during the heating and concentrating in step (2) is controlled to be 200-300 Pa and the temperature is controlled to be 60-65 ℃.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102028861A (en) * | 2009-09-24 | 2011-04-27 | 周艳 | New liver and kidney nourishing decoction preparation (novel medicament delivery system) and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102028861A (en) * | 2009-09-24 | 2011-04-27 | 周艳 | New liver and kidney nourishing decoction preparation (novel medicament delivery system) and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 雷丸等: "金柏胶囊的质量标准研究 ", 《中国药房》 * |
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Application publication date: 20201127 |