CN111956518A - Whitening and freckle-removing cream - Google Patents
Whitening and freckle-removing cream Download PDFInfo
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- CN111956518A CN111956518A CN202010895781.0A CN202010895781A CN111956518A CN 111956518 A CN111956518 A CN 111956518A CN 202010895781 A CN202010895781 A CN 202010895781A CN 111956518 A CN111956518 A CN 111956518A
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- whitening
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The invention discloses a whitening and freckle-removing cream which is prepared from the following raw materials in percentage by mass: 2-5% of ethylhexyl palmitate, 1-3% of squalane, 2-6% of glycerol, 51-3% of steareth, 0.2-1.2% of lauryl glucoside, 0.5-2% of cetearyl alcohol, 1-8% of a whitening agent, 0.2-0.6% of bisabolol, 0.2-0.6% of xanthan gum, 0.05-0.25% of bis (hydroxymethyl) imidazolidinyl urea, 0.05-0.25% of 1, 3-dihydroxymethyl-5, 5-dimethylhydantoin and the balance of water. The whitening and freckle-removing cream disclosed by the invention has the advantages of nourishing skin, fully moisturizing skin, improving dark yellow, repairing and fading freckles and having a good whitening effect.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to whitening and freckle-removing cream.
Background
How to keep skin healthy and whiten is a problem which is very concerned by modern oriental women, and the research and development of cosmetics with safe whitening effects is also a pursuit of technicians in the daily chemical industry.
Human skin tone is largely dependent on the ability of individual melanocytes to produce melanin. There are three essential substances necessary for the formation of melanin: tyrosine is a main raw material for producing melanin; tyrosinase, the major rate-limiting enzyme for the conversion of tyrosine to melanin, is a combination of copper and protein; tyrosine produces melanin under the action of tyrosinase, an oxidative process that must be combined with oxygen to convert to melanin.
Due to the increasing pursuit of white skin and the requirement of preventing and treating skin problems such as skin freckles, chloasma and the like, modern women emerge on the market a great amount of whitening and spot-removing cream containing whitening components such as nicotinamide and arbutin, but the whitening effect cannot meet the public demand and the cost is high.
Disclosure of Invention
Aiming at the problems in the prior art, the invention aims to be realized by the following technical scheme:
the invention discloses a whitening and freckle-removing cream which is prepared from the following raw materials in percentage by mass:
preferably, the whitening and freckle-removing cream is prepared from the following raw materials in percentage by mass:
the whitening and freckle-removing cream can be prepared by a common cosmetic industry universal method, and the preparation method of the whitening and freckle-removing cream is an industry universal technology and does not have any innovation.
Specifically, the following preparation method can be adopted:
1. adding ethylhexyl palmitate, squalane, steareth-5, lauryl glucoside, cetostearyl alcohol, whitening agent, bisabolol, bis (hydroxymethyl) imidazolidinyl urea, 1, 3-dihydroxymethyl-5, 5-dimethylhydantoin into an oil phase pot, heating to 80-85 ℃, and stirring for dissolving uniformly;
2. adding glycerol, xanthan gum and water into a water phase pot, heating to 80-85 deg.C, stirring and dissolving;
3. preheating a reaction kettle to 80-85 ℃, pumping in a water phase, stirring, pumping in an oil phase, and homogenizing for 5-15 minutes;
4. cooling to 25-30 deg.C; and (5) inspecting, discharging, filling and packaging.
The whitening agent consists of a liquorice compound and epoxy alisol.
Further, the whitening agent is prepared from a liquorice compound and epoxy alisol according to the mass ratio of (3-7): 1. Preferably, the mass ratio of the licorice compound to the epoxy alisol is 3:1, 4:1, 5:1, 6:1 or 7: 1.
The Glycyrrhrizae radix compound is at least one of glycyrrhizin, glycyrrhetinic acid, liquiritin, isoliquiritin, neoliquiritin, glycyrrhizin, glycycoumarin and licochalcone A. Further, the licorice compound is at least one of liquiritigenin, glycycoumarin and licochalcone A.
Preferably, the whitening agent is prepared from glycycoumarin and epoxy alisma alkene according to the mass ratio of (3-7): 1. Further preferably, the mass ratio of glycycoumarin to epoxyalisma alkene is 3:1, 4:1, 5:1, 6:1 or 7: 1.
The whitening and freckle-removing cream disclosed by the invention has the advantages of nourishing skin, fully moisturizing skin, improving dark yellow, repairing and fading freckles and having a good whitening effect.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Fig. 1 is a data graph of a whitening performance test of the whitening agent of the present invention.
Fig. 2 is a data diagram of the whitening performance test of the whitening and speckle removing cream of the invention.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The invention discloses a whitening and freckle-removing cream which is prepared from the following raw materials in percentage by mass:
preferably, the whitening and freckle-removing cream is prepared from the following raw materials in percentage by mass:
specifically, the whitening and freckle-removing cream can be prepared by the following method:
1. adding ethylhexyl palmitate, squalane, steareth-5, lauryl glucoside, cetostearyl alcohol, whitening agent, bisabolol, bis (hydroxymethyl) imidazolidinyl urea, 1, 3-dihydroxymethyl-5, 5-dimethylhydantoin into an oil phase pot, heating to 80-85 ℃, and stirring for dissolving uniformly;
2. adding glycerol, xanthan gum and water into a water phase pot, heating to 80-85 deg.C, stirring and dissolving;
3. preheating a reaction kettle to 80-85 ℃, pumping in a water phase, stirring, pumping in an oil phase, and homogenizing for 5-15 minutes;
4. cooling to 25-30 deg.C; and (5) inspecting, discharging, filling and packaging.
The main raw materials in the whitening and freckle-removing cream are introduced as follows:
| name of raw materials | CAS number |
| Ethyl hexyl palmitate | 29806-73-3 |
| Squalane | 111-01-3 |
| Glycerol | 56-81-5 |
| Steareth-5 | 71093-13-5 |
| Lauryl glucoside | 110615-47-9 |
| Cetostearyl alcohol | 246159-33-1 |
| Bisabolol | 515-69-5 |
| Xanthan gum | 11138-66-2 |
| Bis (hydroxymethyl) imidazolidinyl urea | 78491-02-8 |
| 1, 3-dimethylol-5, 5-dimethylhydantoin | 6440-58-0 |
Ethylhexyl palmitate, which is called isooctyl palmitate, octyl palmitate, 2-ethylhexyl palmitate or 2-ethylhexyl palmitate, is a clear and transparent liquid, is tasteless, insoluble in water, is compatible with most solvents, is a high-purity high-grade fatty acid ester product, is mainly used as a cosmetic raw material, and is an excellent skin softening agent. Has stable property, and is not easy to oxidize or generate peculiar smell.
Squalane, which has anticancer, antioxidant, drug-loading, detoxifying, skin moisturizing and emollient activities.
Steareth-5 as emulsifier and surfactant for cosmetics.
Lauryl glucoside, which belongs to the surfactants of alkyl glucosides, has the best cleaning effect in the alkyl glucosides, has fine and smooth foam and is mild, and is commonly used as a cleaning agent, a foam booster, a thickening agent and a surfactant in cosmetics.
The cetearyl alcohol mainly has the effects of a softening agent, a thickening agent and an emulsifying agent in cosmetics and skin care products, is safe in raw materials, has no influence on pregnant women, and has no pox-causing property.
Bisabolol (Bisabolol), also known as Bisabolol and radicellol, is found mainly in chamomile essential oil, gum poplar essential oil, and some essential oils of the genera swamp and sage. Bisabolol has effects of relieving irritation and relieving pain. It has skin caring effect on allergic skin or children skin, and can protect skin from daily tension and accelerate skin healing process.
The xanthan gum is a biopolymer prepared by using corn starch and biological engineering from Xanthomonas campestris with cabbage black rot disease, and is a biological polysaccharide consisting of glucose, mannose, glucuronic acid, acetic acid and pyruvic acid. The molecular structure of xanthan gum determines that it has properties that are incomparable with other polymers: high viscosity at low concentrations; good flowing thixotropy or pseudoplasticity; acid, alkali and salt resistance, oxidation resistance and enzymolysis resistance; the product is temperature resistant, and can be kept stable in a plurality of freezing and unfreezing processes and at a high temperature; good compatibility with acids, bases, salts, reducing agents, surfactants, preservatives, natural or synthetic thickeners in the same solution system; good dispersion effect, emulsion stabilization effect and suspended particle and oil drop capability. And has effects of resisting oxidation and preventing skin aging.
Bis (hydroxymethyl) imidazolidinyl urea and 1, 3-dimethylol-5, 5-dimethylhydantoin are good cosmetic preservatives.
The whitening agent applied by the invention consists of a liquorice compound and epoxy alisol.
The whitening agent is prepared from a liquorice compound and epoxy alisol according to a mass ratio of (3-7): 1. Preferably, the mass ratio of the licorice compound to the epoxy alisol is 3:1, 4:1, 5:1, 6:1 or 7: 1.
The Glycyrrhrizae radix compound is at least one of glycyrrhizin, glycyrrhetinic acid, liquiritin, isoliquiritin, neoliquiritin, glycyrrhizin, glycycoumarin and licochalcone A. Further, the licorice compound is at least one of liquiritigenin, glycycoumarin and licochalcone A.
Preferably, the whitening agent is prepared from glycycoumarin and epoxy alismatis alkene according to the mass ratio of (3-7): 1. Further preferably, the mass ratio of glycycoumarin to epoxyalisma alkene is 3:1, 4:1, 5:1, 6:1 or 7: 1.
The main raw materials of the whitening agent are introduced as follows:
glycycoumarin is a compound extracted from traditional Chinese medicine liquorice, and the application of glycycoumarin in whitening cosmetics is not reported in the prior art.
The epoxy alisma alkene is a sesquiterpenoid compound extracted from alisma orientale, has various pharmacological activities, is commonly used in the field of medicine preparation, and is not reported to be applied to whitening cosmetics in the prior art.
The whitening agent disclosed by the invention is safe and non-irritant, can effectively inhibit the generation of melanin and the expression of tyrosinase, and has a good whitening effect.
Example 1
The whitening agent is prepared by mixing 5 parts by weight of glycycoumarin and 1 part by weight of epoxy alisma alkene.
Example 2
The whitening agent is prepared by mixing 5 parts by weight of licochalcone A and 1 part by weight of epoxy alisma alkene.
Example 3
The whitening agent is prepared by mixing 5 parts by weight of liquiritigenin and 1 part by weight of epoxy alisma alkene.
Example 4
The whitening agent is prepared by mixing 3 parts by weight of glycycoumarin and 1 part by weight of epoxy alisma alkene.
Example 5
The whitening agent is prepared by mixing 7 parts by weight of glycycoumarin and 1 part by weight of epoxy alisma alkene.
Example 6
The whitening agent is prepared by mixing 2 parts by weight of glycycoumarin and 1 part by weight of epoxy alisma alkene.
Example 7
The whitening agent is prepared by mixing 8 parts by weight of glycycoumarin and 1 part by weight of epoxy alisma alkene.
Comparative example 1
The whitening agent is glycycoumarin.
Comparative example 2
The whitening agent is licochalcone A.
Comparative example 3
The whitening agent is liquiritigenin.
Comparative example 4
The whitening agent is epoxy alisol.
Examples 8 to 12
A whitening and freckle-removing cream comprises the following raw materials in percentage by mass:
specifically, the whitening and freckle-removing cream is prepared by the following method:
2. adding ethylhexyl palmitate, squalane, steareth-5, lauryl glucoside, cetostearyl alcohol, whitening agent, bisabolol, bis (hydroxymethyl) imidazolidinyl urea, 1, 3-dihydroxymethyl-5, 5-dimethylhydantoin into an oil phase pot, heating to 80 ℃, and stirring for dissolving uniformly;
2. adding glycerol, xanthan gum and water into a water phase pot, heating to 80 ℃, and stirring to dissolve uniformly;
3. preheating a reaction kettle to 80 ℃, pumping in a water phase, stirring, pumping in an oil phase, and homogenizing for 10 minutes;
4. cooling to 30 ℃; and (5) inspecting, discharging, filling and packaging.
Wherein the content of the first and second substances,
the whitening agent used in example 8 was the whitening agent prepared in example 1.
The whitening agent used in example 9 was the whitening agent prepared in example 4.
The whitening agent used in example 10 was the whitening agent prepared in example 5.
The whitening agent used in example 11 was the whitening agent prepared in comparative example 1.
The whitening agent used in example 12 was the whitening agent prepared in comparative example 4.
Test example 1
The whitening performance of the whitening agent is tested, the specific test method of the invention adopts the tyrosinase activity inhibition rate which is common in the industry to test, and the test method per se belongs to the prior art and is not original by the inventor.
Tyrosinase inhibition assay:
dissolving tyrosinase in phosphate buffer solution with pH of 6.8 to prepare 120U/mL tyrosinase solution;
dissolving L-tyrosine in phosphate buffer solution with pH of 6.8 to prepare 1.6 mol/L-tyrosine solution;
dissolving the whitening agent in a phosphate buffer solution with the pH value of 6.8 to prepare a to-be-detected sample solution of 0.15 mg/mL;
adding 0.5mL of the above sample solution to be tested into 0.5mL of tyrosinase solution and 1.5mL of phosphate buffer solution with the pH value of 6.8, preheating for 15min at 37 ℃, adding 0.5mL of L-tyrosine solution, reacting for 15min at 37 ℃, measuring the light absorption value at 475nm, testing 5 groups of the same sample solution to be tested, and averaging.
Tyrosinase inhibition (%) ([ 1- (D)1-D2)/(D3-D4)]×100
In the above formula, D1: l-tyrosine, the light absorption value of the sample to be detected and the tyrosinase system; d2: the light absorption value of the sample to be detected, the tyrosinase and phosphate buffer solution system; d3: the light absorption values of the L-tyrosine, the tyrosinase system and the phosphate buffer solution; d4: absorbance of tyrosinase with phosphate buffer system.
Table: test result table of whitening performance of whitening agent
| Tyrosinase inhibition rate% | |
| Example 1 | 85.7 |
| Example 2 | 61.6 |
| Example 3 | 64.8 |
| Example 4 | 80.4 |
| Example 5 | 81.2 |
| Example 6 | 67.5 |
| Example 7 | 68.4 |
| Comparative example 1 | 68.9 |
| Comparative example 2 | 70.5 |
| Comparative example 3 | 74.4 |
| Comparative example 4 | 52.7 |
In examples 1, 4 and 5, the mass ratio of the glycycoumarin to the epoxy alisma alkene in the formula of the whitening agent is 5:1, 3:1 and 7:1 respectively, the glycycoumarin and the epoxy alisma alkene have synergistic effect, and the whitening performance (tyrosinase inhibition rate) is obviously superior to that of a comparative example 1 and a comparative example 4 which adopt the glycycoumarin alone.
The whitening agent disclosed by the invention is safe and non-irritant, can effectively inhibit the generation of melanin and the expression of tyrosinase, and has a good whitening effect.
Test example 2
Human skin patch test:
according to the seventh chapter of human skin patch test in technical standards for cosmetic safety (2015 edition), a skin-closed patch test is performed, and a tester: 30, test samples: 1 wt% aqueous solution of whitening agent of example 1.
And (3) testing results: grade 0, 28 people, grade 1, 2 people. The whitening agent is safe and non-irritant.
Test example 3
And carrying out whitening performance test on the whitening and freckle-removing cream.
Tyrosinase inhibition assay:
dissolving tyrosinase in phosphate buffer solution with pH of 6.8 to prepare 120U/mL tyrosinase solution;
dissolving L-tyrosine in phosphate buffer solution with pH of 6.8 to prepare 1.6 mol/L-tyrosine solution;
diluting the whitening and freckle-removing cream with phosphate buffer solution with the same weight and pH value of 6.8 to prepare a sample solution to be detected;
adding 0.5mL of the above sample solution to be tested into 0.5mL of tyrosinase solution and 1.5mL of phosphate buffer solution with the pH value of 6.8, preheating for 15min at 37 ℃, adding 0.5mL of L-tyrosine solution, reacting for 15min at 37 ℃, measuring the light absorption value at 475nm, testing 5 groups of the same sample solution to be tested, and averaging.
Tyrosinase inhibition (%) ([ 1- (D)1-D2)/(D3-D4)]×100
In the above formula, D1: l-tyrosine, the light absorption value of the sample to be detected and the tyrosinase system; d2: the light absorption value of the sample to be detected, the tyrosinase and phosphate buffer solution system; d3: the light absorption values of the L-tyrosine, the tyrosinase system and the phosphate buffer solution; d4: absorbance of tyrosinase with phosphate buffer system.
Table: test result table of whitening and spot-removing cream whitening performance
| Tyrosinase inhibition rate% | |
| Example 8 | 89.2 |
| Example 9 | 85.0 |
| Example 10 | 85.7 |
| Example 11 | 71.6 |
| Example 12 | 58.3 |
Test example 4
According to the seventh chapter of human skin patch test in technical standards for cosmetic safety (2015 edition), a skin-closed patch test is performed, and a tester: 30, test samples: the whitening and freckle-removing cream of example 8.
And (3) testing results: grade 0 was scored for 27 people and grade 1 for 3 people. The whitening and freckle-removing cream is safe and non-irritant.
The above description is only an embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that are not thought of through the inventive work should be included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope defined by the claims.
Claims (4)
1. The whitening and freckle-removing cream comprises the following raw materials in percentage by mass:
the balance being water.
2. The whitening and freckle-removing cream comprises the following raw materials in percentage by mass:
the balance being water.
3. The cream of claim 1 or 2, wherein the whitening agent is composed of a licorice compound and epoxyalisol.
4. The whitening and freckle-removing cream according to claim 1 or 2, wherein the whitening agent is prepared from glycycoumarin and epoxy alismatis alkene in a mass ratio of (3-7): 1, preparing a composition; preferably, the mass ratio of glycycoumarin to epoxyalisma alkene is 3:1, 4:1, 5:1, 6:1 or 7: 1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010895781.0A CN111956518A (en) | 2020-08-31 | 2020-08-31 | Whitening and freckle-removing cream |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010895781.0A CN111956518A (en) | 2020-08-31 | 2020-08-31 | Whitening and freckle-removing cream |
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| CN111956518A true CN111956518A (en) | 2020-11-20 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050118289A1 (en) * | 2002-04-04 | 2005-06-02 | Kaneka Corporation | Process for producing fat composition containing hydrophobic components of glycyrrhiza |
| CN103565800A (en) * | 2013-10-30 | 2014-02-12 | 中国农业大学 | Novel application of glycycoumarin in prevention and treatment of alcoholic liver injury |
| CN111544326A (en) * | 2020-06-15 | 2020-08-18 | 南京奥赛斯生物科技有限公司 | Application of epoxy alisol in whitening and removing freckles |
-
2020
- 2020-08-31 CN CN202010895781.0A patent/CN111956518A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050118289A1 (en) * | 2002-04-04 | 2005-06-02 | Kaneka Corporation | Process for producing fat composition containing hydrophobic components of glycyrrhiza |
| CN103565800A (en) * | 2013-10-30 | 2014-02-12 | 中国农业大学 | Novel application of glycycoumarin in prevention and treatment of alcoholic liver injury |
| CN111544326A (en) * | 2020-06-15 | 2020-08-18 | 南京奥赛斯生物科技有限公司 | Application of epoxy alisol in whitening and removing freckles |
Non-Patent Citations (3)
| Title |
|---|
| 周智明等: "化妆品中植物香豆素的使用情况分析", 《广东化工》 * |
| 杨新玲等: "天然源酪氨酸酶抑制剂研究进展", 《郑州牧业工程高等专科学校学报》 * |
| 舒树苗等: "美白中药与植物药的研究进展", 《国外医药（植物分册）》 * |
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