EP2155149A2 - Pharmaceutical or cosmetic preparations for topical and/or parenteral application, preparation methods thereof and use of same - Google Patents
Pharmaceutical or cosmetic preparations for topical and/or parenteral application, preparation methods thereof and use of sameInfo
- Publication number
- EP2155149A2 EP2155149A2 EP08805683A EP08805683A EP2155149A2 EP 2155149 A2 EP2155149 A2 EP 2155149A2 EP 08805683 A EP08805683 A EP 08805683A EP 08805683 A EP08805683 A EP 08805683A EP 2155149 A2 EP2155149 A2 EP 2155149A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- hyaluronic acid
- chosen
- oligomer
- derivatives
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 13
- 230000000699 topical effect Effects 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title claims description 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 83
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 82
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 81
- 239000000203 mixture Substances 0.000 claims abstract description 71
- 150000001875 compounds Chemical class 0.000 claims abstract description 29
- 150000003839 salts Chemical class 0.000 claims abstract description 17
- 150000004492 retinoid derivatives Chemical class 0.000 claims abstract description 11
- 125000000600 disaccharide group Chemical group 0.000 claims abstract 6
- 230000037303 wrinkles Effects 0.000 claims description 13
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 10
- 238000002347 injection Methods 0.000 claims description 10
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- 238000004519 manufacturing process Methods 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 8
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- 239000000539 dimer Substances 0.000 claims description 6
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 229960003471 retinol Drugs 0.000 claims description 5
- 235000020944 retinol Nutrition 0.000 claims description 5
- 239000011607 retinol Substances 0.000 claims description 5
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- 229960002916 adapalene Drugs 0.000 claims description 2
- LZCDAPDGXCYOEH-UHFFFAOYSA-N adapalene Chemical compound C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21 LZCDAPDGXCYOEH-UHFFFAOYSA-N 0.000 claims description 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims description 2
- 238000001802 infusion Methods 0.000 claims description 2
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- 229920001542 oligosaccharide Polymers 0.000 description 3
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- 229920000642 polymer Polymers 0.000 description 3
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 108030001720 Bontoxilysin Proteins 0.000 description 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 2
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 2
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- AEMOLEFTQBMNLQ-WAXACMCWSA-N alpha-D-glucuronic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-WAXACMCWSA-N 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
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- 229940097043 glucuronic acid Drugs 0.000 description 2
- 229940014041 hyaluronate Drugs 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 230000005847 immunogenicity Effects 0.000 description 2
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- 210000002510 keratinocyte Anatomy 0.000 description 2
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- 229950006780 n-acetylglucosamine Drugs 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 239000003642 reactive oxygen metabolite Substances 0.000 description 2
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
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- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 108010003272 Hyaluronate lyase Proteins 0.000 description 1
- 102000001974 Hyaluronidases Human genes 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 108010057266 Type A Botulinum Toxins Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229930002945 all-trans-retinaldehyde Natural products 0.000 description 1
- XJKITIOIYQCXQR-SCUNHAKFSA-N all-trans-retinyl linoleate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C XJKITIOIYQCXQR-SCUNHAKFSA-N 0.000 description 1
- FXKDHZXYYBPLHI-TUTABMRPSA-N all-trans-retinyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FXKDHZXYYBPLHI-TUTABMRPSA-N 0.000 description 1
- YNGACJMSLZMZOX-FPFNAQAWSA-N all-trans-retinyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C YNGACJMSLZMZOX-FPFNAQAWSA-N 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
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- 230000003416 augmentation Effects 0.000 description 1
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- 239000002585 base Substances 0.000 description 1
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- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 1
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- 239000000463 material Substances 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
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- CBKLICUQYUTWQL-XWGBWKJCSA-N methyl (3s,4r)-3-methyl-1-(2-phenylethyl)-4-(n-propanoylanilino)piperidine-4-carboxylate;oxalic acid Chemical compound OC(=O)C(O)=O.CCC(=O)N([C@]1([C@H](CN(CCC=2C=CC=CC=2)CC1)C)C(=O)OC)C1=CC=CC=C1 CBKLICUQYUTWQL-XWGBWKJCSA-N 0.000 description 1
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- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- NCYCYZXNIZJOKI-OVSJKPMPSA-N retinal group Chemical group C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C NCYCYZXNIZJOKI-OVSJKPMPSA-N 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Definitions
- the present invention relates to compositions for topical and / or parenteral application comprising, in a physiologically acceptable medium, a retinoid and / or its salts and / or derivatives, and an oligomer of hyaluronic acid consisting of 1 to 6 disaccharide units methods of making such compositions, and their uses as pharmaceutical, especially drug, or cosmetic compositions.
- the said compositions being intended for the treatment of dermatological conditions, in particular, the treatment by filling wrinkles, fine lines, fibroblastic depletions and all scars.
- the aging of the skin is one of the most visible changes in the senescence process.
- the skin is exposed to many factors that can accelerate this physiological process.
- intrinsic aging which is easier to evaluate in areas that are normally not exposed to the sun and, on the other hand, extrinsic aging, caused by the interaction of environmental factors, in particular UV rays. These environmental factors have a much greater effect on sun-exposed body parts, especially in light-skinned people.
- actinic aging Other factors such as eating habits, smoking, excessive alcohol consumption, Chronic diseases and dysfunctions of the endocrine glands also contribute to this aging.
- the stratum corneum is little modified.
- the epidermis is atrophic and the dermal-epidermal junction is flattened, so that adhesion to the dermis is less good, facilitating the formation of bubbles.
- the thickness of the dermis is significantly reduced; there are fewer blood vessels. There are also fewer fibroblasts and their biosynthesis and proliferation abilities are diminished.
- the elastic fibers undergo modifications first, and then disappear.
- Wrinkles are the most visible signs of aging. We can distinguish it from several natures, in particular superficial and deep wrinkles. Deep wrinkles may be due to dermo-hypodermic changes, while superficial wrinkles could be explained by dermal and possibly epidermal changes. Wrinkles are mainly due to the loss of elasticity of the skin. The reaching of the network elastic subepidermal gives rise to a superficial laxity of the aged skin and a fold of its surface. The destruction of elastic fibers in the reticular dermis is responsible for the loss of elasticity and the ability of the skin to regain its shape after stretching. Depending on the type, intensity and topography, a suitable treatment will be possible.
- dermal implants that is to say as substances injected directly into the skin, in order to remedy the skin changes resulting from aging. , trauma or disease.
- Botulinum toxin inactivated (Botox®) or the use of laser techniques. These different types of treatment are not exclusive and their combination has even been recommended.
- collagen and hyaluronic acid are the ones that are at the origin of the majority of the products available on the market.
- Hyaluronic acid is a ubiquitous natural polysaccharide that exists in the same form from the simplest bacterium to humans. It is a polysaccharide composed alternately of D-glucuronic acid and N- acetylglucosamine, linked together by alternating glycosidic bonds beta-1,4 and beta-1,3. According to Saari H et al. Differential effects of reactive oxygen species on a native synovial fluid and purified human umbilical cord hyaluronate. Inflammation 17 (1993): 403-415, the polymers of this repeating unit can have a size between 10 2 and 10 4 kDa in vivo, the hyaluronic acid taken from the umbilical cord having a weight of 2500 kDa.
- Hyaluronic acid is a natural component of the dermis where it plays an important role in the hydration and elasticity of the skin. However, it decreases in quantity and quality with age, resulting in drying of the skin that wrinkles. It is highly water soluble and forms high viscosity solutions in water. Because of these particular properties, hyaluronic acid is one of the most widely used pharmaceutical products.
- hyaluronic acid is very quickly eliminated from the plasma by degradation. Its plasma half-life after intravenous injection is very short, between 2.5 and 5.5 minutes, while in the skin, its half-life is 0.5 to 2 days depending on its concentration. Urinary excretion is low, less than 1% of total clearance. In rabbits, the rate of elimination in the skin was measured (Reed RK, Laurent UB, JR Fraser, Laurent TC., Removal rate of [3H] hyaluronan injected subcutaneously in rabbits.) Am J Physiol 1990 Aug; 259 (2Pt 2): H532-5). It is non-exponential with a half-life of 0.5 to 1 day when its concentration is 5 mg / ml. The tolerance of hyaluronic acid is very good and no immunogenicity has been associated with this substance. This has a very low incidence of side effects.
- hyaluronic acid alone or in combination
- injectable compositions such as, for example, hyaluronic acid alone, collagen alone or the combination "hyaluronic acid and collagen" have already been used in reconstructive surgery, in the context of treatment by filling wrinkles, fine lines, fibroblastic depletions and all scars.
- hyaluronic acid because of its low bioavailability after injection and its too high injection frequency, can not be used as such.
- compositions based on hyaluronic acid having a very good bioavailability and likely to better withstand the action of degradation enzymes. This allows, in particular, to space interventions and reduce their number.
- compositions used as a dermal implant are all composed of stabilized hyaluronic acid and many of them comprise chemically modified hyaluronic acid for this purpose.
- the hyaluronic acid included in these products is predominantly of non-human origin such as for example of avian or bacterial origin.
- compositions there are thus in these compositions numerous hyaluronic acid derivatives chemically modified in the form, in particular of esters, of amides, as well as derivatives having "intra and / or interchain bridges"
- a problem to be solved by the invention is to provide compositions which make it possible to ensure that hyaluronic acid has a better bioavailability while retaining its physico-chemical characteristics and its biological properties, as well as a method of manufacturing such compositions.
- the solution of the invention to this problem has as its first object a pharmaceutical or cosmetic composition, especially for topical and / or parenteral application comprising, as sole active ingredients, in a physiologically acceptable medium:
- At least one compound chosen from retinoids, their salts and their derivatives at least one compound chosen from retinoids, their salts and their derivatives
- At least one oligomer of hyaluronic acid chosen from compounds containing from 1 to 6 disaccharide units.
- the composition does not comprise an inhibitor of the degradation of hyaluronic acid.
- composition according to the invention indeed contains as active ingredients only the retinoid (s) and the (e) oligomer of hyaluronic acid; any other active ingredient is excluded.
- Its second object is a process for manufacturing such a pharmaceutical or cosmetic composition, comprising a step of mixing at least one compound chosen from retinoids, their salts and derivatives and at least one selected hyaluronic acid oligomer. among compounds containing from 1 to 6 disaccharide units with a physiologically acceptable medium.
- the method according to the invention also comprises a step of preparing a physiologically acceptable medium, in which the active ingredients are mixed.
- composition according to the invention for the manufacture of a medicament for the treatment and / or prevention of dermatological conditions.
- a pharmaceutical or cosmetic composition according to the invention significantly increases the bioavailability of a hyaluronic acid, which is further included in said composition, or which is administered separately.
- the composition according to the invention makes it possible to space the applications of hyaluronic acid and to reduce the number thereof and it has a significant effectiveness in the filling of wrinkles, fine lines, fibroblastic depletions and all scars.
- the Applicant has demonstrated a decrease in the catabolism of hyaluronic acid in human keratinocytes in vivo to which hyaluronic acid, a hyaluronic acid oligomer chosen from compounds containing from 1 to 6 disaccharide units, and a retinoid, in the absence of an inhibitor of hyaluronic acid degradation.
- the composition comprising a hyaluronic acid oligomer chosen from compounds containing from 1 to 6 disaccharide units and a retinoid confers on hyaluronic acid also applied a better stability and a better bioavailability.
- a composition is more effective than the compositions of the prior art, and in particular compositions comprising inhibitors of the degradation of hyaluronic acid, in the filling of wrinkles, fine lines, fibroblastic depletions and all scars, as well as in hydration. skin.
- the invention will be better understood on reading the nonlimiting description which follows.
- composition according to the invention comprises, in a physiologically acceptable medium, at least one retinoid and / or its salts and / or derivatives and a hyaluronic acid oligomer chosen from compounds containing from 1 to 6 disaccharide units. In particular, it does not include an inhibitor of the degradation of hyaluronic acid.
- composition according to the invention may further comprise hyaluronic acid.
- the composition according to the invention may be administered to a subject to whom hyaluronic acid is independently administered.
- the hyaluronic acid may be included in a separate composition, which may be administered simultaneously or in a different time from that of the administration of the composition according to the invention.
- the distinct composition comprising hyaluronic acid can be administered topically, orally or parenterally, for example by injection.
- Physiologically acceptable medium means a medium compatible with the skin and optionally with its integuments (eyelashes, nails, hair) and / or mucous membranes.
- compositions according to the invention the retinoid and / or its salts and / or its derivatives, and
- the oligomer of hyaluronic acid selected from compounds containing from 1 to 6 disaccharide units and where appropriate, hyaluronic acid, are present in proportions ranging from 0.0000001% to 10%, preferably from 0.00001% to 1% by weight, relative to the total weight of the composition.
- concentration ranges are given, they include the upper and lower limits of said range.
- compositions according to the invention may comprise hyaluronic acid.
- hyaluronic acid is meant a ubiquitous natural polysaccharide existing in the same form from the simplest bacterium to humans. It is a polysaccharide composed alternately of D-glucuronic acid and N-acetylglucosamine, linked together by alternating glycoside bonds beta-1,4 and beta-1,3.
- the polymers of this repeating unit can have a size between 10 2 and 10 4 kDa in vivo, the hyaluronic acid taken from the umbilical cord having a weight of 2500 kDa.
- hyaluronic acid is natural.
- natural hyaluronic acid is meant an unstabilized hyaluronic acid, not chemically modified in the form, in particular of esters, amides, or in the form of derivatives having "intra and / or interchain bridges" (cross linked), such modifications affecting the physico-chemical characteristics and the biological properties of said hyaluronic acid, as well as its fate after administration.
- compositions according to the invention comprise a retinoid and / or its salts and / or its derivatives, taken alone or as a mixture.
- retinoids that may be used in the compositions according to the invention, retinol, retinal, retinoic acid, adapalene or their salts and derivatives, taken alone or as a mixture, more preferably retinol, will preferably be chosen.
- retinoid salt is meant in particular an alkali metal salt, or an alkaline earth salt, or an organic amine salt.
- retinoid derivative is meant in particular the esters, such as retinyl palmitate, retinyl acetate, retinyl stearate, retinyl oleate, retinyl propionate or retinyl linoleate.
- the retinoids used in the compositions according to the invention are retinoids naturally occurring in the human body.
- Oligosaccharide is understood to mean polymers formed of a number n (with n less than or equal to 100) of monosaccharides by glycosidic bond, in particular any oligosaccharide limiting the penetration of hyaluronic acid into skin cells, which are in particular keratinocytes. and fibroblasts.
- n n
- oligosaccharides taken alone or as a mixture, capable of entering into the compositions according to the invention
- the oligomers of hyaluronic acid preferentially the di- to dodecamers of hyaluronic acid, will be chosen, said dimer comprising a disaccharide unit.
- the molecular weight of a disaccharide unit of hyaluronic acid is about 400 Da.
- An oligomer of one to six disaccharide units of hyaluronic acid therefore has a molecular weight of between 400 and 2400 Da.
- Oligomer means, according to IUPAC in Pure Appl. Chem., Vol. 68, No.12, pp. 2287-2311, 1996, a molecule of intermediate molecular weight, the structure of which comprises a small amount of molecules having a lower molecular weight.
- a molecule having an intermediate molecular mass we will speak of a molecule having an intermediate molecular mass, when the removal of one or a few constituent units will significantly modify the properties of the molecule.
- the oligomers of hyaluronic acid taken alone or as a mixture, capable of entering into the compositions according to the invention, are the dimers and four-mers of hyaluronic acid, said dimer comprising a disaccharide unit component of hyaluronic acid. , and the four-mer comprising two of these disaccharide units.
- the molecular weight of a disaccharide unit of hyaluronic acid is about 400 Da.
- An oligomer of one or two disaccharide units of hyaluronic acid therefore has a molecular weight of 400 to 800 Da, respectively.
- the oligomers used in the compositions according to the invention are compounds naturally occurring in the human body.
- one oligomer is used at concentrations of between 10 -9 M and 10 -3 M, preferably between 10 -8 M and 10 -5 M.
- compositions according to the invention do not comprise an inhibitor of the degradation of hyaluronic acid.
- inhibitor of the degradation of hyaluronic acid is meant a compound capable of reducing, or even blocking, the catabolism either extracellular or intracellular of hyaluronic acid, preferably a compound capable of reducing or even blocking the extracellular catabolism of hyaluronic acid, more preferably a compound capable of inhibiting extracellular hyaluronidase present in the skin.
- compositions according to the invention may also contain the usual adjuvants well known to those skilled in the art.
- compositions according to the invention may be formulated for topical and / or parenteral application.
- topical means an external application on the skin or mucous membranes.
- compositions may be in any dosage form normally used for topical administration.
- topical compositions mention may be made of compositions in liquid, pasty or solid form and, more particularly, in the form of ointments, aqueous, hydroalcoholic or oily solutions, and optionally two-phase lotion-type dispersions.
- serum, aqueous, anhydrous or lipophilic gels powders, soaked swabs, syndets, wipes, sprays, foams, sticks, shampoos, compresses, washing bases, emulsions of liquid consistency or semi-liquid of the milk type, obtained by dispersion of a fatty phase in an aqueous phase (O / W) or conversely (W / O), a microemulsion, suspensions or emulsions of soft, semi-liquid or solid white or colored cream, gel or ointment, suspensions of microspheres or nanospheres or lipid or polymeric vesicles, or microcapsules, microparticles or nanoparticles or polymeric or gelled patches allowing release n controlled.
- compositions according to the invention can be applied subcutaneously or intradermally.
- parenteral compositions mention may be made of compositions in the form of solutions or suspensions for infusion or for injection.
- hyaluronic acid may be administered in the form of an injectable aqueous solution and a composition according to the invention.
- invention comprising a dimer of hyaluronic acid is administered in the form of a cream.
- the administration frequencies may be identical or different.
- the frequency of administration of hyaluronic acid injected in the form of an aqueous solution for injection may vary from 4 to 24 months, preferably from 4 to 16 months, while those of composition according to the invention, administered topically, for example in cream form, may vary from 1 to 7 days, preferably from 1 to 3 days.
- the method of manufacturing a composition comprises the steps of preparing a physiologically acceptable medium and mixing an effective amount of a four-mer of hyaluronic acid.
- the invention also relates to the use of at least one compound chosen from retinoids, their salts and derivatives and at least one hyaluronic acid oligomer chosen from compounds containing from 1 to 6 disaccharide units or from 'a composition such as described above, for the manufacture of a medicament for the treatment, improvement and / or prevention of dermatological conditions.
- the invention relates to the use of at least one compound chosen from retinoids, their salts and derivatives and at least one oligomer of hyaluronic acid chosen from compounds containing from 1 to 6 disaccharide units. , or a composition as described above, for the manufacture of a cosmetic or pharmaceutical composition for the treatment, improvement and / or prevention of skin aging.
- Skin aging is understood to mean wrinkles, fine lines, fibroblastic depletions and scars.
- Such a composition is adapted to the treatment of wrinkled and / or aged skin, and is intended in particular to prevent and / or reduce the effects thereof.
- the treatment of wrinkles, fine lines, fibroblastic depletions and all scars is done by filling.
- composition according to the invention can be applied to the areas of the face or forehead marked by expression lines.
- the invention also relates to the use of at least one compound chosen from retinoids, their salts and derivatives and at least one oligomer of hyaluronic acid chosen from compounds containing from 1 to 6 disaccharide units, or of a composition as described above, for the manufacture of a cosmetic or pharmaceutical composition for use in reconstructive surgery.
- the present invention will now be illustrated by the following examples.
- composition is prepared in a conventional manner for the person skilled in the art:
- Example 2 Composition No. 2
- Stearic acid 3.00% mixture of glyceryl monostearate and PEG stearate (100 EO) 2.5%
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Abstract
The invention relates to a pharmaceutical or cosmetic composition for topical and/or parenteral application, containing, in a physiologically acceptable medium, at least one retinoid or the salts and derivatives thereof and at least one hyaluronic acid oligomer selected from among compounds containing between 1 and 6 disaccharide units. The invention is particularly suitable for use in human dermatology and plastic surgery.
Description
PREPARATIONS PHARMACEUTIQUES OU COSMETIQUES POUR PHARMACEUTICAL OR COSMETIC PREPARATIONS FOR
APPLICATION TOPIQUE ET/OU PARENTERALE, LEURS PROCEDES DETOPICAL AND / OR PARENTERAL APPLICATION, THEIR METHODS OF
PREPARATION, ET LEURS UTILISATIONSPREPARATION AND USES THEREOF
La présente invention se rapporte à des compositions pour application topique et/ou parentérale comprenant, dans un milieu physiologiquement acceptable, un rétinoïde et/ou ses sels et/ou ses dérivés, et un oligomère d'acide hyaluronique consistant en 1 à 6 unités disaccharidiques, des procédés de fabrication de telles compositions, et leurs utilisations en tant que composition pharmaceutiques, notamment de médicament, ou cosmétiques. Les dites compositions étant destinées au traitement des affections dermatologiques, en particulier, au traitement par comblement des rides, ridules, déplétions fibroblastiques et toutes cicatrices.The present invention relates to compositions for topical and / or parenteral application comprising, in a physiologically acceptable medium, a retinoid and / or its salts and / or derivatives, and an oligomer of hyaluronic acid consisting of 1 to 6 disaccharide units methods of making such compositions, and their uses as pharmaceutical, especially drug, or cosmetic compositions. The said compositions being intended for the treatment of dermatological conditions, in particular, the treatment by filling wrinkles, fine lines, fibroblastic depletions and all scars.
Le vieillissement de la peau est une des modifications les plus visibles du processus de sénescence. De plus, la peau se retrouve exposée à de nombreux facteurs susceptibles d'accélérer ce processus physiologique. On distingue deux types différents de vieillissement cutané. D'une part, le vieillissement intrinsèque, qu'il est plus facile d'évaluer sur des zones qui normalement ne sont pas exposées au soleil et, d'autre part, le vieillissement extrinsèque, provoqué par l'interaction de facteurs environnementaux, notamment les rayons UV. Ces facteurs environnementaux ont un effet beaucoup plus marqué sur les parties du corps exposées au soleil, surtout chez les personnes de phototype clair. On parle alors également de vieillissement actinique. D'autres facteurs tels que les habitudes alimentaires, le tabagisme, la consommation excessive d'alcool, les
maladies chroniques et les dysfonctionnements des glandes endocrines contribuent également à ce vieillissement.The aging of the skin is one of the most visible changes in the senescence process. In addition, the skin is exposed to many factors that can accelerate this physiological process. There are two different types of skin aging. On the one hand, intrinsic aging, which is easier to evaluate in areas that are normally not exposed to the sun and, on the other hand, extrinsic aging, caused by the interaction of environmental factors, in particular UV rays. These environmental factors have a much greater effect on sun-exposed body parts, especially in light-skinned people. We also speak of actinic aging. Other factors such as eating habits, smoking, excessive alcohol consumption, Chronic diseases and dysfunctions of the endocrine glands also contribute to this aging.
Lors du vieillissement intrinsèque de la peau, la couche cornée est peu modifiée. L'épiderme est atrophique et la jonction dermo-épidermique est aplatie, de sorte que l'adhésion au derme est moins bonne, facilitant la formation de bulles. L'épaisseur du derme est nettement réduite ; il y a moins de vaisseaux sanguins. On observe aussi moins de fibroblastes et leurs capacités de biosynthèse et de prolifération sont diminuées. Les fibres élastiques subissent d'abord des modifications, pour disparaître par la suite.During the intrinsic aging of the skin, the stratum corneum is little modified. The epidermis is atrophic and the dermal-epidermal junction is flattened, so that adhesion to the dermis is less good, facilitating the formation of bubbles. The thickness of the dermis is significantly reduced; there are fewer blood vessels. There are also fewer fibroblasts and their biosynthesis and proliferation abilities are diminished. The elastic fibers undergo modifications first, and then disappear.
En ce qui concerne le vieillissement extrinsèque, on observe un épiderme irrégulier, parfois atrophique, parfois hyperplasique, avec des signes de désorganisation et de dysplasie. Les mélanocytes sont plus nombreux à certains endroits, et en nombre réduit à d'autres. Il y a aussi une irrégularité de la distribution de la mélanine dans l'épiderme, suite à des problèmes de transfert des mélanosomes. Le nombre de cellules de Langerhans diminue. Les petits vaisseaux sanguins sont d'abord dilatés, pour ensuite s'amincir et s'atrophier.As far as extrinsic aging is concerned, there is an irregular epidermis, sometimes atrophic, sometimes hyperplastic, with signs of disorganization and dysplasia. Melanocytes are more numerous in some places, and fewer in number. There is also an irregular distribution of melanin in the epidermis, following problems of melanosome transfer. The number of Langerhans cells decreases. The small blood vessels are first dilated, then thin and atrophy.
Les rides sont les signes les plus visibles du vieillissement. On en distingue de plusieurs natures, notamment les rides superficielles et profondes. Les rides profondes seraient dues aux modifications dermo- hypodermiques, tandis que les rides superficielles pourraient s'expliquer par des modifications dermiques et éventuellement épidermiques . Les rides sont surtout dues à la perte d'élasticité de la peau. L'atteinte du réseau
élastique sous-épidermique donne lieu à une laxité superficielle de la peau vieillie et à un plissement de sa surface. La destruction des fibres élastiques dans le derme réticulaire est responsable de la perte d'élasticité et de la capacité de la peau à reprendre sa forme après étirement. Selon le type, l'intensité et la topographie, un traitement adapté sera possible.Wrinkles are the most visible signs of aging. We can distinguish it from several natures, in particular superficial and deep wrinkles. Deep wrinkles may be due to dermo-hypodermic changes, while superficial wrinkles could be explained by dermal and possibly epidermal changes. Wrinkles are mainly due to the loss of elasticity of the skin. The reaching of the network elastic subepidermal gives rise to a superficial laxity of the aged skin and a fold of its surface. The destruction of elastic fibers in the reticular dermis is responsible for the loss of elasticity and the ability of the skin to regain its shape after stretching. Depending on the type, intensity and topography, a suitable treatment will be possible.
Le traitement des modifications cutanées inesthétiques liées au vieillissement a fait d'énormes progrès ces dernières années.The treatment of unsightly skin changes related to aging has made tremendous progress in recent years.
Un nombre relativement important de substances naturelles ou synthétiques ont d'ores et déjà été décrites en tant qu'implants dermiques, c'est-à-dire en tant que substances injectées directement dans la peau, afin de remédier aux altérations cutanées résultant du vieillissement, de traumatismes ou de maladies.A relatively large number of natural or synthetic substances have already been described as dermal implants, that is to say as substances injected directly into the skin, in order to remedy the skin changes resulting from aging. , trauma or disease.
D'autres alternatives thérapeutiques pour ces applications sont notamment l'injection locale de la toxine botulique désactivée (Botox®) ou l'utilisation de techniques laser. Ces différents types de traitement ne sont pas exclusifs et leur combinaison a même été recommandée. Parmi les substances naturelles d'origine humaine, le collagène et l'acide hyaluronique sont celles qui sont à l'origine de la majorité des produits disponibles sur le marché.Other therapeutic alternatives for these applications include local injection of botulinum toxin inactivated (Botox®) or the use of laser techniques. These different types of treatment are not exclusive and their combination has even been recommended. Among the natural substances of human origin, collagen and hyaluronic acid are the ones that are at the origin of the majority of the products available on the market.
L'acide hyaluronique est un polysaccharide naturel ubiquitaire qui existe sous la même forme de la plus simple bactérie à l'Homme. C'est un polysaccharide composé alternativement d'acide D-glucuronique et de N-
acétylglucosamine, liés entre eux par des liaisons glycosidiques alternées beta-1,4 et beta-1,3. Selon Saari H et al. Differential effects of reactive oxygen species on native synovial fluid and purified human umbilical cord hyaluronate. Inflammation 17 ( 1993 ): 403-415, les polymères de cette unité récurrente peuvent avoir une taille entre 102 et 104 kDa in vivo, l'acide hyaluronique prélevé dans le cordon ombilical présentant un poids de 2500 kDa.Hyaluronic acid is a ubiquitous natural polysaccharide that exists in the same form from the simplest bacterium to humans. It is a polysaccharide composed alternately of D-glucuronic acid and N- acetylglucosamine, linked together by alternating glycosidic bonds beta-1,4 and beta-1,3. According to Saari H et al. Differential effects of reactive oxygen species on a native synovial fluid and purified human umbilical cord hyaluronate. Inflammation 17 (1993): 403-415, the polymers of this repeating unit can have a size between 10 2 and 10 4 kDa in vivo, the hyaluronic acid taken from the umbilical cord having a weight of 2500 kDa.
L'acide hyaluronique représente notamment un constituant naturel du derme où il joue un rôle important dans l'hydratation et l'élasticité de la peau. Il diminue cependant en quantité et en qualité avec l'âge, entraînant un dessèchement de la peau qui se ride. Il est très hydrosoluble et forme des solutions à haute viscosité dans l'eau. Du fait de ces propriétés particulières, l'acide hyaluronique fait partie des produits pharmaceutiques les plus utilisés.Hyaluronic acid is a natural component of the dermis where it plays an important role in the hydration and elasticity of the skin. However, it decreases in quantity and quality with age, resulting in drying of the skin that wrinkles. It is highly water soluble and forms high viscosity solutions in water. Because of these particular properties, hyaluronic acid is one of the most widely used pharmaceutical products.
Toutefois, chez l'Homme, l'acide hyaluronique est très rapidement éliminé du plasma par dégradation. Sa demi-vie plasmatique après injection intraveineuse est très courte, entre 2,5 et 5,5 minutes, alors que dans la peau, sa demi-vie est de 0,5 à 2 jours selon sa concentration. Son excrétion urinaire est faible, inférieure à 1% de la clairance totale. Chez le lapin, la vitesse d'élimination, dans la peau, a été mesurée (Reed RK, Laurent UB, Fraser JR, Laurent TC. Removal rate of [3H] hyaluronan injected subcutaneously in rabbits. Am J Physiol. 1990 Aug;259(2 Pt 2):H532-5). Elle est non exponentielle avec une demi-vie de 0,5 à 1 jour quand sa concentration est de 5 mg/ml .
La tolérance de l'acide hyaluronique est très bonne et aucune immunogénicité n'a été associée à cette substance. On retrouve ainsi une incidence d'effets secondaires très faible.However, in humans, hyaluronic acid is very quickly eliminated from the plasma by degradation. Its plasma half-life after intravenous injection is very short, between 2.5 and 5.5 minutes, while in the skin, its half-life is 0.5 to 2 days depending on its concentration. Urinary excretion is low, less than 1% of total clearance. In rabbits, the rate of elimination in the skin was measured (Reed RK, Laurent UB, JR Fraser, Laurent TC., Removal rate of [3H] hyaluronan injected subcutaneously in rabbits.) Am J Physiol 1990 Aug; 259 (2Pt 2): H532-5). It is non-exponential with a half-life of 0.5 to 1 day when its concentration is 5 mg / ml. The tolerance of hyaluronic acid is very good and no immunogenicity has been associated with this substance. This has a very low incidence of side effects.
L'utilisation de l'acide hyaluronique, seul ou en association, a ainsi été décrite pour plusieurs applications médicales, telles que par exemple le traitement de l 'ostéoarthrite ainsi que l'arthrite rhumatoïde. Des compositions injectables telles que par exemple l'acide hyaluronique seul, le collagène seul ou l'association « acide hyaluronique et collagène » ont déjà été utilisées en chirurgie réparatrice, dans le cadre de traitement par comblement des rides, ridules, déplétions fibroblastiques et toutes cicatrices.The use of hyaluronic acid, alone or in combination, has thus been described for several medical applications, such as, for example, the treatment of osteoarthritis as well as rheumatoid arthritis. Injectable compositions such as, for example, hyaluronic acid alone, collagen alone or the combination "hyaluronic acid and collagen" have already been used in reconstructive surgery, in the context of treatment by filling wrinkles, fine lines, fibroblastic depletions and all scars.
Actuellement, de nombreux implants dermiques sont utilisés mais aucun n'a encore été considéré comme idéal dans le cadre d'une augmentation tissulaire sûre et saineCurrently, many dermal implants are used but none has yet been considered ideal for safe and healthy tissue augmentation.
(Naoum C, Dasiou-Plakida D. Dermal filler materials and botulin toxin Int J Dermatol. 2001 Oct; 40 (10) : 609-21) .(Naoum C, Dasiou-Plakida Dermal Filler Materials and Botulinum toxin Int J Dermatol 2001 Oct; 40 (10): 609-21).
Cependant, l'acide hyaluronique, en raison de sa biodisponibilité trop faible après injection et sa fréquence d'injection trop élevée, ne peut être utilisé en tant que tel.However, hyaluronic acid, because of its low bioavailability after injection and its too high injection frequency, can not be used as such.
Bien sûr, on a cherché à développer des compositions à base d'acide hyaluronique possédant une très bonne biodisponibilité et susceptibles de mieux résister à l'action des enzymes de dégradation. Ceci permet,
notamment, d'espacer les interventions et d'en réduire le nombre .Of course, attempts have been made to develop compositions based on hyaluronic acid having a very good bioavailability and likely to better withstand the action of degradation enzymes. This allows, in particular, to space interventions and reduce their number.
Ces compositions utilisées en tant qu'implant dermique sont toutes composées d'acide hyaluronique stabilisé et un grand nombre d'entre elles comprennent de l'acide hyaluronique modifié chimiquement dans ce but. En outre, l'acide hyaluronique inclus dans ces produits est majoritairement d'origine non humaine telle que par exemple d'origine aviaire ou bactérienne.These compositions used as a dermal implant are all composed of stabilized hyaluronic acid and many of them comprise chemically modified hyaluronic acid for this purpose. In addition, the hyaluronic acid included in these products is predominantly of non-human origin such as for example of avian or bacterial origin.
On retrouve ainsi dans ces compositions de nombreux dérivés d'acide hyaluronique modifiés chimiquement sous forme, notamment d'esters, d'amides, ainsi que des dérivés possédant des « ponts intra et/ou interchaînes »There are thus in these compositions numerous hyaluronic acid derivatives chemically modified in the form, in particular of esters, of amides, as well as derivatives having "intra and / or interchain bridges"
(cross-linked) .(cross-linked).
Cependant, ces modifications affectent les caractéristiques physico-chimiques et les propriétés biologiques de l'acide hyaluronique, son immunogénicité potentielle ainsi que son devenir après administration. Ces modifications structurelles de l'acide hyaluronique peuvent entraîner des réactions inflammatoires comme le reporte Sopaar CNS, Patrinely JR Ophtalmie plastic and reconstructive surgery 2005 Mar ; 21(2) : 151-53.However, these modifications affect the physico-chemical characteristics and the biological properties of hyaluronic acid, its potential immunogenicity and its fate after administration. These structural modifications of hyaluronic acid can lead to inflammatory reactions as reported by Sopaar CNS, Patrinely JR Ophthalmic Plastic and Reconstructive Surgery 2005 Mar; 21 (2): 151-53.
Compte tenu de ce qui précède, un problème que se propose de résoudre l'invention est de réaliser des compositions permettant d'assurer à l'acide hyaluronique une meilleure biodisponibilité tout en conservant ses caractéristiques physico-chimiques et ses propriétés biologiques, ainsi qu'un procédé de fabrication de telles compositions .
La solution de l'invention à ce problème posé a pour premier objet une composition pharmaceutique ou cosmétique, notamment pour application topique et/ou parentérale comprenant, à titre de seuls principes actifs, dans un milieu physiologiquement acceptable :In view of the foregoing, a problem to be solved by the invention is to provide compositions which make it possible to ensure that hyaluronic acid has a better bioavailability while retaining its physico-chemical characteristics and its biological properties, as well as a method of manufacturing such compositions. The solution of the invention to this problem has as its first object a pharmaceutical or cosmetic composition, especially for topical and / or parenteral application comprising, as sole active ingredients, in a physiologically acceptable medium:
- au moins un composé choisi parmi les rétinoïdes leurs sels et leurs dérivés, etat least one compound chosen from retinoids, their salts and their derivatives, and
- au moins un oligomère d'acide hyaluronique choisi parmi les composés contenant de 1 à 6 unités disaccharidiques .at least one oligomer of hyaluronic acid chosen from compounds containing from 1 to 6 disaccharide units.
De préférence, la composition ne comprend pas d'inhibiteur de la dégradation de l'acide hyaluronique.Preferably, the composition does not comprise an inhibitor of the degradation of hyaluronic acid.
La composition selon l'invention contient en effet comme principes actifs uniquement le(s) rétinoïde(s) et l' (es) oligomère d'acide hyaluronique ; tout autre principe actif est exclu.The composition according to the invention indeed contains as active ingredients only the retinoid (s) and the (e) oligomer of hyaluronic acid; any other active ingredient is excluded.
Elle a pour deuxième objet un procédé de fabrication d'une telle composition pharmaceutique ou cosmétique, comprenant une étape de mélange d'au moins un composé choisi parmi les rétinoïdes, leurs sels et leurs dérivés et d'au moins oligomère d'acide hyaluronique choisi parmi les composés contenant de 1 à 6 unités disaccharidiques avec un milieu physiologiquement acceptable. De préférence, le procédé selon l'invention comprend également une étape de préparation d'un milieu physiologiquement acceptable, dans lequel les actifs sont mélangés.Its second object is a process for manufacturing such a pharmaceutical or cosmetic composition, comprising a step of mixing at least one compound chosen from retinoids, their salts and derivatives and at least one selected hyaluronic acid oligomer. among compounds containing from 1 to 6 disaccharide units with a physiologically acceptable medium. Preferably, the method according to the invention also comprises a step of preparing a physiologically acceptable medium, in which the active ingredients are mixed.
Enfin, elle a pour troisième objet l'utilisation d'une composition selon l'invention pour la fabrication
d'un médicament destiné au traitement et/ou à la prévention des affections dermatologiques.Finally, its third object is the use of a composition according to the invention for the manufacture of a medicament for the treatment and / or prevention of dermatological conditions.
Une composition pharmaceutique ou cosmétique selon l'invention augmente nettement la biodisponibilité d'un acide hyaluronique, qui est compris en outre dans ladite composition, ou bien qui est administré séparément. La composition selon l'invention permet d'espacer les applications d'acide hyaluronique et d'en réduire le nombre et elle présente une efficacité importante dans le comblement des rides, ridules, déplétions fibroblastiques et toutes cicatrices.A pharmaceutical or cosmetic composition according to the invention significantly increases the bioavailability of a hyaluronic acid, which is further included in said composition, or which is administered separately. The composition according to the invention makes it possible to space the applications of hyaluronic acid and to reduce the number thereof and it has a significant effectiveness in the filling of wrinkles, fine lines, fibroblastic depletions and all scars.
La Demanderesse a mis en évidence une diminution du catabolisme de l'acide hyaluronique dans des kératinocytes humains in vivo sur lesquels sont appliqués de l'acide hyaluronique, un oligomère d'acide hyaluronique choisi parmi les composés contenant de 1 à 6 unités disaccharidiques et un rétinoïde, en l'absence d'un inhibiteur de la dégradation d'acide hyaluronique.The Applicant has demonstrated a decrease in the catabolism of hyaluronic acid in human keratinocytes in vivo to which hyaluronic acid, a hyaluronic acid oligomer chosen from compounds containing from 1 to 6 disaccharide units, and a retinoid, in the absence of an inhibitor of hyaluronic acid degradation.
Ainsi, de manière surprenante, la composition comprenant un oligomère d'acide hyaluronique choisi parmi les composés contenant de 1 à 6 unités disaccharidiques et un rétinoïde confère à l'acide hyaluronique également appliqué une meilleure stabilité et une meilleure biodisponibilité. Une telle composition est plus efficace que les compositions de l'art antérieur, et notamment des compositions comprenant des inhibiteurs de la dégradation d'acide hyaluronique, dans le comblement des rides, ridules, déplétions fibroblastiques et toutes cicatrices, ainsi que dans l'hydratation de la peau.
L'invention sera mieux comprise à la lecture de la description non limitative qui va suivre.Thus, surprisingly, the composition comprising a hyaluronic acid oligomer chosen from compounds containing from 1 to 6 disaccharide units and a retinoid confers on hyaluronic acid also applied a better stability and a better bioavailability. Such a composition is more effective than the compositions of the prior art, and in particular compositions comprising inhibitors of the degradation of hyaluronic acid, in the filling of wrinkles, fine lines, fibroblastic depletions and all scars, as well as in hydration. skin. The invention will be better understood on reading the nonlimiting description which follows.
La composition selon l'invention comprend, dans un milieu physiologiquement acceptable, au moins un rétinoïde et/ou ses sels et/ou ses dérivés et un oligomère d'acide hyaluronique choisi parmi les composés contenant de 1 à 6 unités disaccharidiques . En particulier, elle ne comprend pas d'inhibiteur de la dégradation de l'acide hyaluronique.The composition according to the invention comprises, in a physiologically acceptable medium, at least one retinoid and / or its salts and / or derivatives and a hyaluronic acid oligomer chosen from compounds containing from 1 to 6 disaccharide units. In particular, it does not include an inhibitor of the degradation of hyaluronic acid.
La composition selon l'invention peut comprendre en outre de l'acide hyaluronique. Ou bien, la composition selon l'invention peut être administrée chez un sujet auquel de l'acide hyaluronique est administré de manière indépendante. Dans ce cas, l'acide hyaluronique peut être compris dans une composition distincte, qui peut être administrée de manière simultanée ou bien en un temps différent de celui de l'administration de la composition selon l'invention. La composition distincte comprenant de l'acide hyaluronique peut être administrée de façon topique, orale ou parentérale, par exemple par injection.The composition according to the invention may further comprise hyaluronic acid. Alternatively, the composition according to the invention may be administered to a subject to whom hyaluronic acid is independently administered. In this case, the hyaluronic acid may be included in a separate composition, which may be administered simultaneously or in a different time from that of the administration of the composition according to the invention. The distinct composition comprising hyaluronic acid can be administered topically, orally or parenterally, for example by injection.
Par milieu physiologiquement acceptable selon l'invention, on entend un milieu compatible avec la peau et éventuellement avec ses phanères (cils, ongles, cheveux) et/ou les muqueuses.Physiologically acceptable medium according to the invention means a medium compatible with the skin and optionally with its integuments (eyelashes, nails, hair) and / or mucous membranes.
Dans les compositions selon l'invention, le rétinoïde et/ou ses sels et/ou ses dérivés, etIn the compositions according to the invention, the retinoid and / or its salts and / or its derivatives, and
1 'oligomère d'acide hyaluronique choisi parmi les composés contenant de 1 à 6 unités disaccharidiques et,
le cas échéant, l'acide hyaluronique, sont présents en proportions pouvant aller de 0,0000001% à 10%, préférentiellement de 0,00001% à 1% en poids, par rapport au poids total de la composition. Dans la présente description, et à moins qu'il ne soit spécifié autrement, il est entendu que, lorsque des intervalles de concentrations sont donnés, ils incluent les bornes supérieures et inférieures dudit intervalle.The oligomer of hyaluronic acid selected from compounds containing from 1 to 6 disaccharide units and where appropriate, hyaluronic acid, are present in proportions ranging from 0.0000001% to 10%, preferably from 0.00001% to 1% by weight, relative to the total weight of the composition. In the present description, and unless otherwise specified, it is understood that when concentration ranges are given, they include the upper and lower limits of said range.
Les compositions selon l'invention peuvent comprendre de l'acide hyaluronique.The compositions according to the invention may comprise hyaluronic acid.
Par acide hyaluronique, on entend un polysaccharide naturel ubiquitaire existant sous la même forme de la plus simple bactérie à l'Homme. C'est un polysaccharide composé alternativement d'acide D-glucuronique et de N- acétylglucosamine, liés entre eux par des liaisons glycosidiques alternées beta-1,4 et beta-1,3. Selon Saari H et al. Differential effects of reactive oxygen species on native synovial fluid and purified human umbilical cord hyaluronate. Inflammation 17 ( 1993 ): 403-415, les polymères de cette unité récurrente peuvent avoir une taille entre 102 et 104 kDa in vivo, l'acide hyaluronique prélevé dans le cordon ombilical présentant un poids de 2500 kDa.By hyaluronic acid is meant a ubiquitous natural polysaccharide existing in the same form from the simplest bacterium to humans. It is a polysaccharide composed alternately of D-glucuronic acid and N-acetylglucosamine, linked together by alternating glycoside bonds beta-1,4 and beta-1,3. According to Saari H et al. Differential effects of reactive oxygen species on a native synovial fluid and purified human umbilical cord hyaluronate. Inflammation 17 (1993): 403-415, the polymers of this repeating unit can have a size between 10 2 and 10 4 kDa in vivo, the hyaluronic acid taken from the umbilical cord having a weight of 2500 kDa.
De façon avantageuse, l'acide hyaluronique est naturel .Advantageously, hyaluronic acid is natural.
Par acide hyaluronique naturel, on entend un acide hyaluronique non stabilisé, non modifié chimiquement sous forme, notamment d'esters, d'amides, ou sous forme de dérivés possédant des « ponts intra et/ou interchaines »
(cross linked) , de telles modifications affectant les caractéristiques physico-chimiques et les propriétés biologiques dudit acide hyaluronique, ainsi que son devenir après administration.By natural hyaluronic acid is meant an unstabilized hyaluronic acid, not chemically modified in the form, in particular of esters, amides, or in the form of derivatives having "intra and / or interchain bridges" (cross linked), such modifications affecting the physico-chemical characteristics and the biological properties of said hyaluronic acid, as well as its fate after administration.
Les compositions selon l'invention comprennent un rétinoïde et/ou ses sels et/ou ses dérivés, pris seuls ou en mélange.The compositions according to the invention comprise a retinoid and / or its salts and / or its derivatives, taken alone or as a mixture.
Parmi les rétinoïdes susceptibles d'entrer dans les compositions selon l'invention, on choisira préférentiellement le rétinol, le rétinal, l'acide rétinoïque, l'adapalène ou leurs sels et dérivés, pris seuls ou en mélange, plus préférentiellement le rétinol.Among the retinoids that may be used in the compositions according to the invention, retinol, retinal, retinoic acid, adapalene or their salts and derivatives, taken alone or as a mixture, more preferably retinol, will preferably be chosen.
Par sel de rétinoïde, on entend notamment un sel de métal alcalin, ou un sel alcalino-terreux, ou un sel d'aminé organique. Par dérivé de rétinoïde, on entend notamment les esters, tels que le rétinyl palmitate, le rétinyl acétate, le rétinyl stéarate, le rétinyl oléate, le rétinyl propionate ou encore le rétinyl linoléate.By retinoid salt is meant in particular an alkali metal salt, or an alkaline earth salt, or an organic amine salt. By retinoid derivative is meant in particular the esters, such as retinyl palmitate, retinyl acetate, retinyl stearate, retinyl oleate, retinyl propionate or retinyl linoleate.
De façon avantageuse, les rétinoïdes utilisés dans les compositions selon l'invention sont des rétinoïdes existant naturellement dans l'organisme humain.Advantageously, the retinoids used in the compositions according to the invention are retinoids naturally occurring in the human body.
Par oligosaccharide, on entend des polymères formés d'un nombre n (avec n inférieur ou égal à 100) de monosaccharides par liaison glycosidique notamment tout oligosaccharide limitant la pénétration de l'acide hyaluronique dans les cellules de la peau, qui sont notamment les kératinocytes et les fibroblastes .
Parmi les oligosaccharides, pris seuls ou en mélange, susceptibles d'entrer dans les compositions selon l'invention, on choisira les oligomères de l'acide hyaluronique, préférentiellement les di- à dodécamères de l'acide hyaluronique, ledit dimère comprenant une unité disaccharidique composante de l'acide hyaluronique, et le dodécamère comprenant six de ces unités disaccharidiques, plus préférentiellement les tétra- à hexamères de l'acide hyaluronique, plus préférentiellement le pentamère de l'acide hyaluronique. Le poids moléculaire d'une unité disaccharidique d'acide hyaluronique est d'environ 400 Da. Un oligomère de une à six unités disaccharidiques d'acide hyaluronique a donc un poids moléculaire compris entre 400 à 2400 Da.Oligosaccharide is understood to mean polymers formed of a number n (with n less than or equal to 100) of monosaccharides by glycosidic bond, in particular any oligosaccharide limiting the penetration of hyaluronic acid into skin cells, which are in particular keratinocytes. and fibroblasts. Among the oligosaccharides, taken alone or as a mixture, capable of entering into the compositions according to the invention, the oligomers of hyaluronic acid, preferentially the di- to dodecamers of hyaluronic acid, will be chosen, said dimer comprising a disaccharide unit. component of hyaluronic acid, and the dodecamer comprising six of these disaccharide units, more preferably the tetra-hexamers of hyaluronic acid, more preferably the pentamer of hyaluronic acid. The molecular weight of a disaccharide unit of hyaluronic acid is about 400 Da. An oligomer of one to six disaccharide units of hyaluronic acid therefore has a molecular weight of between 400 and 2400 Da.
Par oligomère on entend, selon l' IUPAC dans Pure Appl. Chem., Vol. 68, No.12, pp. 2287-2311, 1996, une molécule de masse moléculaire intermédiaire, dont la structure comprend une petite quantité de molécules ayant une masse moléculaire plus faible. On parlera de molécule ayant une masse moléculaire intermédiaire, lorsque le retrait d'une ou de quelques unités constituantes modifiera significativement les propriétés de la molécule .Oligomer means, according to IUPAC in Pure Appl. Chem., Vol. 68, No.12, pp. 2287-2311, 1996, a molecule of intermediate molecular weight, the structure of which comprises a small amount of molecules having a lower molecular weight. We will speak of a molecule having an intermediate molecular mass, when the removal of one or a few constituent units will significantly modify the properties of the molecule.
Les oligomères d'acide hyaluronique, pris seuls ou en mélange, susceptibles d'entrer dans les compositions selon l'invention, sont les dimères et quatre-mères de l'acide hyaluronique, ledit dimère comprenant une unité disaccharidique composante de l'acide hyaluronique, et le quatre-mère comprenant deux de ces unités disaccharidiques. Le poids moléculaire d'une unité disaccharidique d'acide hyaluronique est d'environ 400
Da. Un oligomère de une ou deux unités disaccharidiques d'acide hyaluronique a donc un poids moléculaire, respectivement, de 400 à 800 Da.The oligomers of hyaluronic acid, taken alone or as a mixture, capable of entering into the compositions according to the invention, are the dimers and four-mers of hyaluronic acid, said dimer comprising a disaccharide unit component of hyaluronic acid. , and the four-mer comprising two of these disaccharide units. The molecular weight of a disaccharide unit of hyaluronic acid is about 400 Da. An oligomer of one or two disaccharide units of hyaluronic acid therefore has a molecular weight of 400 to 800 Da, respectively.
De façon avantageuse, les oligomères utilisés dans les compositions selon l'invention sont des composés existant de façon naturelle dans l'organisme humain.Advantageously, the oligomers used in the compositions according to the invention are compounds naturally occurring in the human body.
Dans les compositions selon l'invention, 1 'oligomère est utilisé à des concentrations comprises entre 10-9 M et 10-3 M, préférentiellement entre 10-8 M et 10-5 M.In the compositions according to the invention, one oligomer is used at concentrations of between 10 -9 M and 10 -3 M, preferably between 10 -8 M and 10 -5 M.
Les compositions selon l'invention ne comprennent pas d'inhibiteur de la dégradation de l'acide hyaluronique.The compositions according to the invention do not comprise an inhibitor of the degradation of hyaluronic acid.
Par inhibiteur de la dégradation de l'acide hyaluronique, on entend un composé capable de diminuer, voire de bloquer, le catabolisme soit extracellulaire soit intracellulaire de l'acide hyaluronique, préférentiellement un composé capable de diminuer, voire de bloquer, le catabolisme extracellulaire de l'acide hyaluronique, plus préférentiellement un composé capable d'inhiber la hyaluronidase extracellulaire présente dans la peau.By inhibitor of the degradation of hyaluronic acid is meant a compound capable of reducing, or even blocking, the catabolism either extracellular or intracellular of hyaluronic acid, preferably a compound capable of reducing or even blocking the extracellular catabolism of hyaluronic acid, more preferably a compound capable of inhibiting extracellular hyaluronidase present in the skin.
De façon connue, les compositions selon l'invention peuvent contenir également les adjuvants habituels bien connus de l'homme de l'art.In known manner, the compositions according to the invention may also contain the usual adjuvants well known to those skilled in the art.
Les compositions selon l'invention peuvent être formulées pour une application par voie topique et/ou parentérale .
Par voie topique, on entend une application externe sur la peau ou les muqueuses.The compositions according to the invention may be formulated for topical and / or parenteral application. By topical means an external application on the skin or mucous membranes.
Par voie topique, les compositions peuvent se présenter sous toutes les formes galéniques normalement utilisées pour une administration par voie topique. A titre d'exemple non limitatif de compositions topiques, on peut citer des compositions sous forme liquide, pâteuse, ou solide et, plus particulièrement, sous forme d'onguents, de solutions aqueuses, hydroalcooliques ou huileuses, de dispersions du type lotion éventuellement biphasée, de sérum, de gels aqueux, anhydres ou lipophiles, de poudres, de tampons imbibés, de syndets, de lingettes, de sprays, de mousses, de sticks, de shampoings, de compresses, de bases lavantes, d'émulsions de consistance liquide ou semi-liquide du type lait, obtenues par dispersion d'une phase grasse dans une phase aqueuse (H/E) ou inversement (E/H) , d'une microémulsion, de suspensions ou émulsions de consistance molle, semi- liquide ou solide du type crème blanche ou colorée, gel ou pommade, de suspensions de microsphères ou nanosphères ou de vésicules lipidiques ou polymériques, ou de microcapsules, micro- ou nanoparticules ou de patchs polymériques ou gélifiés permettant une libération contrôlée.Topically, the compositions may be in any dosage form normally used for topical administration. By way of non-limiting example of topical compositions, mention may be made of compositions in liquid, pasty or solid form and, more particularly, in the form of ointments, aqueous, hydroalcoholic or oily solutions, and optionally two-phase lotion-type dispersions. , serum, aqueous, anhydrous or lipophilic gels, powders, soaked swabs, syndets, wipes, sprays, foams, sticks, shampoos, compresses, washing bases, emulsions of liquid consistency or semi-liquid of the milk type, obtained by dispersion of a fatty phase in an aqueous phase (O / W) or conversely (W / O), a microemulsion, suspensions or emulsions of soft, semi-liquid or solid white or colored cream, gel or ointment, suspensions of microspheres or nanospheres or lipid or polymeric vesicles, or microcapsules, microparticles or nanoparticles or polymeric or gelled patches allowing release n controlled.
Par voie parentérale, les compositions selon l'invention peuvent être appliquées par voie sous-cutanée ou intradermique. A titre d'exemple non limitatif de compositions parentérales, on peut citer des compositions sous forme de solutions ou suspensions pour perfusion ou pour injection.
A titre d'exemple non limitatif donné simplement à titre d'illustration et qui ne saurait en aucune façon limiter la portée de l'invention, de l'acide hyaluronique peut être administré sous forme d'une solution aqueuse injectable et une composition selon l'invention comprenant un dimère d'acide hyaluronique est administrée sous forme d'une crème.Parenterally, the compositions according to the invention can be applied subcutaneously or intradermally. By way of nonlimiting example of parenteral compositions, mention may be made of compositions in the form of solutions or suspensions for infusion or for injection. By way of nonlimiting example given merely by way of illustration and which in no way limits the scope of the invention, hyaluronic acid may be administered in the form of an injectable aqueous solution and a composition according to the invention. invention comprising a dimer of hyaluronic acid is administered in the form of a cream.
Dans le cadre d'une administration combinée d'acide hyaluronique et d'une composition selon l'invention, les fréquences d'administration peuvent être identiques ou différentes .In the context of a combined administration of hyaluronic acid and a composition according to the invention, the administration frequencies may be identical or different.
De manière avantageuse dans le cadre de l'invention, la fréquence d'administration de l'acide hyaluronique injecté sous forme d'une solution aqueuse injectable peut varier de 4 à 24 mois, préférentiellement de 4 à 16 mois, alors que celles de la composition selon l'invention, administrée topiquement, par exemple sous forme de crème, peut varier de 1 à 7 jours, préférentiellement de 1 à 3 jours .Advantageously in the context of the invention, the frequency of administration of hyaluronic acid injected in the form of an aqueous solution for injection may vary from 4 to 24 months, preferably from 4 to 16 months, while those of composition according to the invention, administered topically, for example in cream form, may vary from 1 to 7 days, preferably from 1 to 3 days.
Selon un mode particulier de l'invention, le procédé de fabrication d'une composition comprend les étapes de préparation d'un milieu physiologiquement acceptable et de mélange d'une quantité efficace d'un quatre-mère de l'acide hyaluronique.According to one particular embodiment of the invention, the method of manufacturing a composition comprises the steps of preparing a physiologically acceptable medium and mixing an effective amount of a four-mer of hyaluronic acid.
L'invention se rapporte également à l'utilisation d'au moins un composé choisi parmi les rétinoïdes, leurs sels et leurs dérivés et d'au moins un oligomère d'acide hyaluronique choisi parmi les composés contenant de 1 à 6 unités disaccharidiques ou d'une composition telle que
décrite précédemment, pour la fabrication d'un médicament destiné au traitement, à l'amélioration et/ou à la prévention des affections dermatologiques.The invention also relates to the use of at least one compound chosen from retinoids, their salts and derivatives and at least one hyaluronic acid oligomer chosen from compounds containing from 1 to 6 disaccharide units or from 'a composition such as described above, for the manufacture of a medicament for the treatment, improvement and / or prevention of dermatological conditions.
Plus particulièrement, l'invention se rapporte à l'utilisation d'au moins un composé choisi parmi les rétinoïdes, leurs sels et leurs dérivés et d'au moins un oligomère d'acide hyaluronique choisi parmi les composés contenant de 1 à 6 unités disaccharidiques, ou d'une composition telle que décrite précédemment, pour la fabrication d'une composition cosmétique ou pharmaceutique destinée au traitement, à l'amélioration et/ou à la prévention du vieillissement cutané. Par vieillissement cutané, on entend les rides, les ridules, les déplétions fibroblastiques et les cicatrices. Une telle composition est adaptée au traitement de la peau ridée et/ou âgée, et vise notamment à en prévenir et/ou à en réduire les effets. Le traitement des rides, ridules, déplétions fibroblastiques et toutes cicatrices se fait notamment par comblement.More particularly, the invention relates to the use of at least one compound chosen from retinoids, their salts and derivatives and at least one oligomer of hyaluronic acid chosen from compounds containing from 1 to 6 disaccharide units. , or a composition as described above, for the manufacture of a cosmetic or pharmaceutical composition for the treatment, improvement and / or prevention of skin aging. Skin aging is understood to mean wrinkles, fine lines, fibroblastic depletions and scars. Such a composition is adapted to the treatment of wrinkled and / or aged skin, and is intended in particular to prevent and / or reduce the effects thereof. The treatment of wrinkles, fine lines, fibroblastic depletions and all scars is done by filling.
En particulier, la composition selon l'invention peut être appliquée sur les zones du visage ou du front marquées par des rides d'expression.In particular, the composition according to the invention can be applied to the areas of the face or forehead marked by expression lines.
L'invention se rapporte également à l'utilisation d'au moins un composé choisi parmi les rétinoïdes, leurs sels et leurs dérivés et d'au moins un oligomère d'acide hyaluronique choisi parmi les composés contenant de 1 à 6 unités disaccharidiques, ou d'une composition telle que décrite précédemment, pour la fabrication d'une composition cosmétique ou pharmaceutique destinée à être utilisée en chirurgie réparatrice.
La présente invention va maintenant être illustrée au moyen des exemples suivants.The invention also relates to the use of at least one compound chosen from retinoids, their salts and derivatives and at least one oligomer of hyaluronic acid chosen from compounds containing from 1 to 6 disaccharide units, or of a composition as described above, for the manufacture of a cosmetic or pharmaceutical composition for use in reconstructive surgery. The present invention will now be illustrated by the following examples.
Exemple 1 : Composition n°lExample 1 Composition No. 1
Solution injectable n°lSolution for injection no.
Cette composition est préparée de manière classique pour l'homme du métier:This composition is prepared in a conventional manner for the person skilled in the art:
Quatre-mère (NAC-Glucuronic acid) 2 0,002% Rétinol 0,00001% Eau qsp 100%Four-mother (NAC-Glucuronic acid) 2 0.002% Retinol 0.00001% Water qs 100%
Exemple 2 : Composition n°2Example 2: Composition No. 2
Solution injectable n°2 d'acide hyaluronique couplée à une crème selon l'inventionSolution for injection No. 2 hyaluronic acid coupled to a cream according to the invention
Solution injectable Acide hyaluronique 2% Eau qsp 100%Injection solution Hyaluronic acid 2% Water qs 100%
CrèmeCream
Dimère (NAC-Glucuronic acid) 1 0,002% Rétinol 0,00001%Dimer (NAC-Glucuronic acid) 1 0.002% Retinol 0.00001%
Acide stéarique 3,00% mélange de monostéarate de glycéryle et de stéarate de PEG (100 OE) 2,5%Stearic acid 3.00% mixture of glyceryl monostearate and PEG stearate (100 EO) 2.5%
Stéarate de PEG (20 OE) 1,0%
Cyclopentadiméthylsiloxane 10, 00%PEG Stearate (20 EO) 1.0% Cyclopentadimethylsiloxane 10, 00%
Huiles végétales 7,00%Vegetable oils 7,00%
Huiles synthétiques 6,00%Synthetic oils 6,00%
Gomme de silicone 0,20%Silicone gum 0,20%
Alcool stéarique 1,00%Stearic alcohol 1.00%
Eau qsp 100%
Water qs 100%
Claims
1. Composition pharmaceutique ou cosmétique comprenant, dans un milieu physiologiquement acceptable, à titre de seuls principes actifs :1. A pharmaceutical or cosmetic composition comprising, in a physiologically acceptable medium, as sole active ingredients:
- au moins un composé choisi parmi les rétinoïdes, leurs sels et leurs dérivés, etat least one compound chosen from retinoids, their salts and their derivatives, and
- au moins un oligomère d'acide hyaluronique choisi parmi les composés contenant de 1 à 6 unités disaccharidiques .at least one oligomer of hyaluronic acid chosen from compounds containing from 1 to 6 disaccharide units.
2. Composition selon la revendication 1, caractérisée en ce que le rétinoïde est choisi parmi le rétinol, la tretinoine et l'adapalene.2. Composition according to claim 1, characterized in that the retinoid is selected from retinol, tretinoin and adapalene.
3. Composition selon l'une des revendications 1 ou 2, caractérisée en que 1 'oligomère d'acide hyaluronique est choisi parmi les dimères et quatre-mères d'acide hyaluronique .3. Composition according to one of claims 1 or 2, characterized in that the hyaluronic acid oligomer is chosen from dimers and four-mers of hyaluronic acid.
4. Composition selon l'une quelconque des revendications 1 à 3, caractérisée en ce qu'elle est formulée pour une application par voie topique.4. Composition according to any one of claims 1 to 3, characterized in that it is formulated for topical application.
5. Composition selon l'une des revendications 1 à 3, caractérisée en ce qu'elle est formulée pour une application par voie parentérale.5. Composition according to one of claims 1 to 3, characterized in that it is formulated for parenteral application.
6. Composition selon la revendication 5, caractérisée en ce qu'elle se présente sous forme de solutions ou suspensions pour perfusion ou pour injection . 6. Composition according to claim 5, characterized in that it is in the form of solutions or suspensions for infusion or injection.
7. Procédé de préparation d'une composition selon l'une des revendications 1 à 6, comprenant une étape de mélange d'au moins un composé choisi parmi les rétinoïdes, leurs sels et leurs dérivés, et d'au moins un oligomère d'acide hyaluronique choisi parmi les composés contenant de 1 à 6 unités disaccharidiques avec un milieu physiologiquement acceptable.7. Process for the preparation of a composition according to one of claims 1 to 6, comprising a step of mixing at least one compound selected from retinoids, their salts and derivatives, and at least one oligomer of hyaluronic acid selected from compounds containing from 1 to 6 disaccharide units with a physiologically acceptable medium.
8. Utilisation d'au moins un composé choisi parmi les rétinoïdes, leurs sels et leurs dérivés et d'au moins un oligomère d'acide hyaluronique choisi parmi les composés contenant de 1 à 6 unités disaccharidiques, pour la fabrication d'une composition pharmaceutique ou cosmétique destinée au traitement, à la prévention ou à l'amélioration du vieillissement cutané.8. Use of at least one compound chosen from retinoids, their salts and derivatives and at least one hyaluronic acid oligomer chosen from compounds containing from 1 to 6 disaccharide units, for the manufacture of a pharmaceutical composition or cosmetic for the treatment, prevention or improvement of skin aging.
9. Utilisation d'au moins un composé choisi parmi les rétinoïdes, leurs sels et leurs dérivés et d'au moins un oligomère d'acide hyaluronique choisi parmi les composés contenant de 1 à 6 unités disaccharidiques pour la fabrication d'une composition pharmaceutique ou cosmétique destinée au traitement par comblement des rides, des ridules, des déplétions fibroblastiques et des cicatrices .9. Use of at least one compound chosen from retinoids, their salts and derivatives and at least one oligomer of hyaluronic acid chosen from compounds containing from 1 to 6 disaccharide units for the manufacture of a pharmaceutical composition or cosmetic treatment for filling wrinkles, fine lines, fibroblastic depletions and scars.
10. Utilisation d'au moins un composé choisi parmi les rétinoïdes, leurs sels et leurs dérivés et d'au moins un oligomère d'acide hyaluronique choisi parmi les composés contenant de 1 à 6 unités disaccharidiques pour la fabrication d'une composition pharmaceutique ou cosmétique destinée à être utilisé en chirurgie réparatrice . 10. Use of at least one compound chosen from retinoids, their salts and derivatives and at least one hyaluronic acid oligomer chosen from compounds containing from 1 to 6 disaccharide units for the manufacture of a pharmaceutical composition or cosmetic for use in reconstructive surgery.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0755034 | 2007-05-11 | ||
| PCT/FR2008/050728 WO2008148967A2 (en) | 2007-05-11 | 2008-04-22 | Pharmaceutical or cosmetic preparations for topical and/or parenteral application, preparation methods thereof and use of same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP2155149A2 true EP2155149A2 (en) | 2010-02-24 |
Family
ID=38828706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP08805683A Withdrawn EP2155149A2 (en) | 2007-05-11 | 2008-04-22 | Pharmaceutical or cosmetic preparations for topical and/or parenteral application, preparation methods thereof and use of same |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20100298259A1 (en) |
| EP (1) | EP2155149A2 (en) |
| CA (1) | CA2686558A1 (en) |
| WO (1) | WO2008148967A2 (en) |
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| FR2861734B1 (en) | 2003-04-10 | 2006-04-14 | Corneal Ind | CROSSLINKING OF LOW AND HIGH MOLECULAR MASS POLYSACCHARIDES; PREPARATION OF INJECTABLE SINGLE PHASE HYDROGELS; POLYSACCHARIDES AND HYDROGELS OBTAINED |
| PL2818184T3 (en) | 2007-11-16 | 2019-06-28 | Aclaris Therapeutics, Inc. | Compositions and methods for treating Purpura |
| US8394782B2 (en) | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having increased longevity |
| US8450475B2 (en) | 2008-08-04 | 2013-05-28 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
| JP5722217B2 (en) | 2008-09-02 | 2015-05-20 | アラーガン・ホールディングス・フランス・ソシエテ・パール・アクシオン・サンプリフィエＡｌｌｅｒｇａｎ Ｈｏｌｄｉｎｇｓ Ｆｒａｎｃｅ Ｓ．Ａ．Ｓ． | Yarn of hyaluronic acid and / or its derivative, method for its preparation and use thereof |
| US9114188B2 (en) | 2010-01-13 | 2015-08-25 | Allergan, Industrie, S.A.S. | Stable hydrogel compositions including additives |
| US20110172180A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
| EP2544652A2 (en) | 2010-03-12 | 2013-01-16 | Allergan Industrie SAS | A fluid composition comprising a hyaluronan polymer and mannitol for improving skin condition. |
| EP3520827B1 (en) | 2010-03-22 | 2022-05-25 | Allergan, Inc. | Cross-linked hydrogels for soft tissue augmentation |
| US8883139B2 (en) | 2010-08-19 | 2014-11-11 | Allergan Inc. | Compositions and soft tissue replacement methods |
| US9005605B2 (en) | 2010-08-19 | 2015-04-14 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8889123B2 (en) | 2010-08-19 | 2014-11-18 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US9393263B2 (en) | 2011-06-03 | 2016-07-19 | Allergan, Inc. | Dermal filler compositions including antioxidants |
| US9408797B2 (en) | 2011-06-03 | 2016-08-09 | Allergan, Inc. | Dermal filler compositions for fine line treatment |
| KR102015676B1 (en) | 2011-06-03 | 2019-10-21 | 알러간, 인코포레이티드 | Dermal filler compositions including antioxidants |
| US20130096081A1 (en) | 2011-06-03 | 2013-04-18 | Allergan, Inc. | Dermal filler compositions |
| US20130244943A1 (en) | 2011-09-06 | 2013-09-19 | Allergan, Inc. | Hyaluronic acid-collagen matrices for dermal filling and volumizing applications |
| US9662422B2 (en) | 2011-09-06 | 2017-05-30 | Allergan, Inc. | Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation |
| ITMI20120027A1 (en) * | 2012-01-12 | 2013-07-13 | New Yemaya Internat Srl | COSMETIC COMPOSITION WITH REVITALIZING ACTION ON THE EPIDERMIDE |
| EP3620184A1 (en) | 2014-09-30 | 2020-03-11 | Allergan Industrie, SAS | Stable hydrogel compositions including additives |
| JP6656804B2 (en) * | 2014-11-26 | 2020-03-04 | 小林製薬株式会社 | External composition |
| WO2016128783A1 (en) | 2015-02-09 | 2016-08-18 | Allergan Industrie Sas | Compositions and methods for improving skin appearance |
| FR3034989B1 (en) * | 2015-04-20 | 2017-05-19 | Soc De Rech Cosmetique Sarl | COSMETIC COMPOSITIONS COMPRISING HYALURONIC ACID OLIGOMERS AND DEDIFFERENCED AND ELICITED BAGGING VEGETABLE CELLS ENCAPSULATING A SAFFRON EXTRACT |
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| US4439614A (en) * | 1982-09-22 | 1984-03-27 | Sri International | 5,6-Methano-5,6-dihydroretinoids |
| US4879114A (en) * | 1985-12-20 | 1989-11-07 | Angio-Medical Corporation | Lipids from omentum and methods for cosmetic use |
| MY105521A (en) * | 1989-04-17 | 1994-10-31 | Healthpoint Ltd | Moisturizing vehicle for topical application of vitamin a acid. |
| WO1994001074A1 (en) * | 1992-07-13 | 1994-01-20 | Shiseido Company, Ltd. | Composition for dermatologic preparation |
| GB9419715D0 (en) * | 1994-09-30 | 1994-11-16 | Boots Co Plc | Hair stimulant composition |
| US5723139A (en) * | 1996-09-27 | 1998-03-03 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Skin care compositions containing a polycyclic triterpene carboxylic acid and a retinoid |
| FR2779059B1 (en) * | 1998-05-29 | 2004-09-10 | Guerlain | COSMETIC TREATMENT PROCESS FOR COMBATING THE EFFECTS OF CUTANEOUS AGING; NEW COSMETIC COMPOSITIONS FOR ITS IMPLEMENTATION |
| DE59906391D1 (en) * | 1998-12-23 | 2003-08-28 | Esparma Gmbh | AGENT FOR PROTECTING THE SKIN CONTAINING HYDROLYSED HYALURONIC ACID |
| JP3641152B2 (en) * | 1999-02-17 | 2005-04-20 | 株式会社ヤクルト本社 | Topical skin preparation |
| KR100332031B1 (en) * | 1999-06-03 | 2002-04-10 | 서경배 | A composition for external application having effects of improving wrinkle and suppressing wrinkle formation |
| ITMI20020756A1 (en) * | 2002-04-09 | 2003-10-09 | Sinclair Pharma S R L | TOPICAL PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DERMATITIS |
| WO2004000242A1 (en) * | 2002-06-25 | 2003-12-31 | Cosmeceutic Solutions Pty Ltd | Topical cosmetic compositions |
| ITMI20022745A1 (en) * | 2002-12-23 | 2004-06-24 | Coimex Scrl United Companies | MIXED ESTERS OF HYALURONIC ACID FOR CYTOSTATIC AND MANUFACTURING ACTIVITIES AND PROCEDURE FOR THEIR PRODUCTION. |
| ITMI20032019A1 (en) * | 2003-10-17 | 2005-04-18 | Fidia Farmaceutici | MICROEMULSIONS OF RETINOIDS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM |
| US7491709B2 (en) * | 2005-07-01 | 2009-02-17 | Wayne Carey | Treatment with hyaluronic acid |
| FR2894827B1 (en) * | 2005-12-21 | 2010-10-29 | Galderma Res & Dev | PHARMACEUTICAL OR COSMETIC PREPARATIONS FOR TOPICAL AND / OR PARENTERAL APPLICATION, PROCESSES FOR THEIR PREPARATION, AND USES THEREOF |
-
2008
- 2008-04-22 EP EP08805683A patent/EP2155149A2/en not_active Withdrawn
- 2008-04-22 CA CA002686558A patent/CA2686558A1/en not_active Abandoned
- 2008-04-22 US US12/599,510 patent/US20100298259A1/en not_active Abandoned
- 2008-04-22 WO PCT/FR2008/050728 patent/WO2008148967A2/en active Application Filing
Non-Patent Citations (1)
| Title |
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| See references of WO2008148967A2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008148967A3 (en) | 2009-02-19 |
| US20100298259A1 (en) | 2010-11-25 |
| WO2008148967A2 (en) | 2008-12-11 |
| CA2686558A1 (en) | 2008-12-11 |
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