CN111870553B - Cosmetic whitening agent and biological whitening cosmetic - Google Patents
Cosmetic whitening agent and biological whitening cosmetic Download PDFInfo
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- CN111870553B CN111870553B CN202010895816.0A CN202010895816A CN111870553B CN 111870553 B CN111870553 B CN 111870553B CN 202010895816 A CN202010895816 A CN 202010895816A CN 111870553 B CN111870553 B CN 111870553B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention discloses a cosmetic whitening agent and a biological whitening cosmetic. The cosmetic whitening agent is prepared from a licorice compound and epoxy alisol according to a mass ratio of (3-7): 1. The Glycyrrhrizae radix compound is at least one of glycyrrhizin, glycyrrhetinic acid, liquiritin, isoliquiritin, neoliquiritin, glycyrrhizin, glycycoumarin and licochalcone A. The cosmetic whitening agent disclosed by the invention is safe and non-irritant, can effectively inhibit the generation of melanin and the expression of tyrosinase, and has a good whitening effect.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to a cosmetic whitening agent and a biological whitening cosmetic.
Background
How to keep skin healthy and whiten is a problem which is very concerned by modern oriental women, and the research and development of cosmetics with safe whitening effects is also a pursuit of technicians in the daily chemical industry.
Human skin tone is largely dependent on the ability of individual melanocytes to produce melanin. There are three essential substances necessary for the formation of melanin: tyrosine is a main raw material for producing melanin; tyrosinase, the major rate-limiting enzyme for the conversion of tyrosine to melanin, is a combination of copper and protein; tyrosine produces melanin under the action of tyrosinase, an oxidative process that must be combined with oxygen to convert to melanin.
Due to the increasing pursuit of white skin and the requirement of preventing and treating skin problems such as skin freckles, chloasma and the like, modern women emerge a large amount of cosmetics containing whitening components such as niacinamide and arbutin on the market, but the whitening effect cannot meet the public demand and the cost is high.
Disclosure of Invention
Aiming at the problems in the prior art, the invention aims to be realized by the following technical scheme:
the invention discloses a cosmetic whitening agent, which consists of a liquorice compound and epoxy alisol.
Further, in the above-mentioned case,
a cosmetic whitening agent comprises a licorice compound and an epoxy alisol according to a mass ratio of (3-7): 1. Preferably, the mass ratio of the licorice compound to the epoxyalisol is 3.
The Glycyrrhrizae radix compound is at least one of glycyrrhizin, glycyrrhetinic acid, liquiritin, isoliquiritin, neoliquiritin, glycyrrhizin, glycycoumarin and licochalcone A.
Further, the licorice compound is at least one of liquiritigenin, glycycoumarin and licochalcone A.
Preferably, the cosmetic whitening agent is prepared from glycycoumarin and epoxy alisma alkene according to the mass ratio of (3-7): 1. Further preferably, the mass ratio of glycycoumarin to epoxyaliskiren is 3.
The invention also discloses application of the cosmetic whitening agent, and the cosmetic whitening agent is used for inhibiting the generation of melanin and/or inhibiting the expression of tyrosinase.
The invention also discloses a biological whitening cosmetic, which comprises the cosmetic whitening agent.
Preferably, a biological whitening cosmetic comprises 0.2-10wt% of the above cosmetic whitening agent. The content of the cosmetic whitening agent in the biological whitening cosmetic is preferably 0.5 to 8wt%, and more preferably 0.5wt%, 1wt%, 2wt%, 3wt%, 4wt%, 5wt%, 6wt%, 7wt%, 8wt%.
The cosmetic whitening agent disclosed by the invention is safe and non-irritant, can effectively inhibit the generation of melanin and the expression of tyrosinase, and has a good whitening effect.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the prior art descriptions will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a data graph of a whitening performance test of a cosmetic whitening agent according to the present invention.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The invention discloses a cosmetic whitening agent, which consists of a liquorice compound and epoxy alisol.
A cosmetic whitening agent comprises a licorice compound and epoxy alisol according to a mass ratio of (3-7): 1. Preferably, the mass ratio of the licorice compound to the epoxyalisol is 3.
The Glycyrrhrizae radix compound is at least one of glycyrrhizin, glycyrrhetinic acid, liquiritin, isoliquiritin, neoliquiritin, glycyrrhizin, glycycoumarin and licochalcone A. Further, the licorice compound is at least one of liquiritigenin, glycycoumarin and licochalcone A.
Preferably, the cosmetic whitening agent is prepared from glycycoumarin and epoxy alisol according to the mass ratio (3-7): 1. Further preferably, the mass ratio of glycycoumarin to epoxyaliskiren is 3.
Glycycoumarin is a compound extracted from traditional Chinese medicine liquorice, and the application of glycycoumarin in whitening cosmetics is not reported in the prior art.
The epoxy alisma alkene is a sesquiterpenoid compound extracted from alisma orientale, has various pharmacological activities, is commonly used in the field of medicine preparation, and is not reported to be applied to whitening cosmetics in the prior art.
The invention also discloses application of the cosmetic whitening agent, and the cosmetic whitening agent is used for inhibiting the generation of melanin and/or inhibiting the expression of tyrosinase.
The invention also discloses a biological whitening cosmetic, which comprises the cosmetic whitening agent.
Preferably, a biological whitening cosmetic comprises 0.2-10wt% of the above cosmetic whitening agent. The content of the cosmetic whitening agent in the biological whitening cosmetic is preferably 0.5 to 8wt%, and more preferably 0.5wt%, 1wt%, 2wt%, 3wt%, 4wt%, 5wt%, 6wt%, 7wt%, 8wt%.
The cosmetic whitening agent disclosed by the invention is safe and non-irritant, can effectively inhibit the generation of melanin and the expression of tyrosinase, and has a good whitening effect.
Example 1
The cosmetic whitening agent is prepared by mixing 5 parts by weight of glycycoumarin and 1 part by weight of epoxy alisma alkene.
Example 2
The cosmetic whitening agent is prepared by mixing 5 parts by weight of licochalcone A and 1 part by weight of epoxy alisol.
Example 3
The cosmetic whitening agent is prepared by mixing 5 parts by weight of liquiritigenin and 1 part by weight of epoxy alisma alkene.
Example 4
The cosmetic whitening agent is prepared by mixing 3 parts by weight of glycycoumarin and 1 part by weight of epoxy alisma alkene.
Example 5
The cosmetic whitening agent is prepared by mixing 7 parts by weight of glycycoumarin and 1 part by weight of epoxy alisma alkene.
Example 6
The cosmetic whitening agent is prepared by mixing 2 parts by weight of glycycoumarin and 1 part by weight of epoxy alisma alkene.
Example 7
The cosmetic whitening agent is prepared by mixing 8 parts by weight of glycycoumarin and 1 part by weight of epoxy alisma alkene.
Comparative example 1
The cosmetic whitening agent is glycycoumarin.
Comparative example 2
The cosmetic whitening agent is licochalcone A.
Comparative example 3
The cosmetic whitening agent is liquiritigenin.
Comparative example 4
The cosmetic whitening agent is epoxy alisol.
Example 8
A biological whitening facial cleanser comprises 1wt% of the cosmetic whitening agent of the embodiment 1 and 99wt% of Dabao clear moisturizing facial cleanser.
Example 9
A biological whitening lotion comprising 1wt% of the cosmetic whitening agent of example 1, 99wt% of a Nivea/Nivea deep skin lotion (national cosmetic special letter G20150528).
Test example 1
The whitening performance of the cosmetic whitening agent is tested, the specific test method of the invention adopts the tyrosinase activity inhibition rate which is universal in the industry to test, and the test method belongs to the prior art and is not original by the inventor.
Tyrosinase inhibition assay:
the tyrosinase was dissolved in phosphate buffer with pH =6.8 to prepare 120U/mL tyrosinase solution;
dissolving L-tyrosine in phosphate buffer solution with pH =6.8 to prepare 1.6 mol/L-tyrosine solution;
dissolving a cosmetic whitening agent in a phosphate buffer solution with the pH =6.8 to prepare a sample solution to be detected of 0.15 mg/mL;
taking 0.5mL of the sample solution to be tested, adding 0.5mL of tyrosinase solution and 1.5mL of phosphate buffer solution with the pH value of 6.8, preheating for 15min at 37 ℃, adding 0.5mL of L-tyrosine solution, reacting for 15min at 37 ℃, measuring a light absorption value at 475nm, testing 5 groups of the same sample solution to be tested, and taking an average value.
Tyrosinase inhibition (%) = [1- (D) 1 -D 2 )/(D 3 -D 4 )]×100
In the above formula, D 1 : l-tyrosine, the light absorption value of the sample to be detected and the tyrosinase system; d 2 : the light absorption value of the sample to be detected, the tyrosinase and phosphate buffer solution system; d 3 : the light absorption values of the L-tyrosine, the tyrosinase system and the phosphate buffer solution; d 4 : absorbance of tyrosinase with phosphate buffer system.
Table: test result table for whitening performance of cosmetic whitening agent
| Tyrosinase inhibition rate% | |
| Example 1 | 85.7 |
| Example 2 | 61.6 |
| Example 3 | 64.8 |
| Example 4 | 80.4 |
| Example 5 | 81.2 |
| Example 6 | 67.5 |
| Practice ofExample 7 | 68.4 |
| Comparative example 1 | 68.9 |
| Comparative example 2 | 70.5 |
| Comparative example 3 | 74.4 |
| Comparative example 4 | 52.7 |
In examples 1, 4 and 5, the mass ratio of the glycycoumarin to the epoxy alismatis alkene in the formula of the cosmetic whitening agent is respectively 5.
The cosmetic whitening agent disclosed by the invention is safe and non-irritant, can effectively inhibit the generation of melanin and the expression of tyrosinase, and has a good whitening effect.
Test example 2
Human skin patch test:
according to the seventh chapter of human skin patch test in technical standards for cosmetic safety (2015 edition), a skin-closed patch test is performed, and a tester: 30, test samples: 1wt% aqueous solution of cosmetic whitening agent of example 1.
And (3) testing results: grade 0, 28 people, grade 1, 2 people were scored.
The above description is only an embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that are not thought of through the inventive work should be included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope defined by the claims.
Claims (6)
1. A cosmetic whitening agent is characterized by comprising a licorice compound and epoxy alismatis ene; the licorice compound is glycycoumarin; the mass ratio of the glycycoumarin to the epoxyalisma alkene is 3.
2. Use of the cosmetic whitening agent according to claim 1, for inhibiting the production of melanin and/or inhibiting the expression of tyrosinase.
3. A biological whitening cosmetic comprising the cosmetic whitening agent according to claim 1.
4. The biological whitening cosmetic of claim 3, comprising 0.2 to 10wt% of the cosmetic whitening agent.
5. The biological whitening cosmetic of claim 4, wherein the content of the cosmetic whitening agent in the biological whitening cosmetic is 0.5 to 8wt%.
6. The biological whitening cosmetic of claim 5, wherein the cosmetic whitening agent is present in the biological whitening cosmetic in an amount of 0.5wt%, 1wt%, 2wt%, 3wt%, 4wt%, 5wt%, 6wt%, 7wt% or 8wt%.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010895816.0A CN111870553B (en) | 2020-08-31 | 2020-08-31 | Cosmetic whitening agent and biological whitening cosmetic |
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| CN202010895816.0A CN111870553B (en) | 2020-08-31 | 2020-08-31 | Cosmetic whitening agent and biological whitening cosmetic |
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| CN111870553A CN111870553A (en) | 2020-11-03 |
| CN111870553B true CN111870553B (en) | 2022-12-06 |
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| CN114652629B (en) * | 2022-04-01 | 2023-07-14 | 上海萧雅生物科技股份有限公司 | Plant source component composition with tyrosinase inhibitory activity and application thereof in preparing freckle-removing and whitening cosmetics |
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