CN111955609A - Preparation method of water-soluble auxiliary agent for veterinary drug, aquatic product and feed additive - Google Patents
Preparation method of water-soluble auxiliary agent for veterinary drug, aquatic product and feed additive Download PDFInfo
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- CN111955609A CN111955609A CN202010890803.4A CN202010890803A CN111955609A CN 111955609 A CN111955609 A CN 111955609A CN 202010890803 A CN202010890803 A CN 202010890803A CN 111955609 A CN111955609 A CN 111955609A
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- 239000012752 auxiliary agent Substances 0.000 title claims abstract description 28
- 239000003674 animal food additive Substances 0.000 title claims abstract description 18
- 239000000273 veterinary drug Substances 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000000843 powder Substances 0.000 claims abstract description 14
- 238000001816 cooling Methods 0.000 claims abstract description 13
- 238000001035 drying Methods 0.000 claims abstract description 13
- 239000000463 material Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 238000004090 dissolution Methods 0.000 claims abstract description 7
- 238000005054 agglomeration Methods 0.000 claims abstract description 6
- 230000002776 aggregation Effects 0.000 claims abstract description 6
- 238000004806 packaging method and process Methods 0.000 claims abstract description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 42
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 36
- 239000011707 mineral Substances 0.000 claims description 36
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 30
- 239000011734 sodium Substances 0.000 claims description 30
- 229910052708 sodium Inorganic materials 0.000 claims description 30
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 26
- 239000011777 magnesium Substances 0.000 claims description 26
- 229910052749 magnesium Inorganic materials 0.000 claims description 26
- 239000000126 substance Substances 0.000 claims description 26
- 229910052742 iron Inorganic materials 0.000 claims description 21
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 19
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 19
- 239000011575 calcium Substances 0.000 claims description 19
- 229910052791 calcium Inorganic materials 0.000 claims description 19
- 239000011701 zinc Substances 0.000 claims description 19
- 229910052725 zinc Inorganic materials 0.000 claims description 19
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 18
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 18
- 229910052802 copper Inorganic materials 0.000 claims description 18
- 239000010949 copper Substances 0.000 claims description 18
- 239000011591 potassium Substances 0.000 claims description 18
- 229910052700 potassium Inorganic materials 0.000 claims description 18
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 16
- 229910052748 manganese Inorganic materials 0.000 claims description 16
- 239000011572 manganese Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 9
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 8
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 8
- 239000004472 Lysine Substances 0.000 claims description 8
- 239000000654 additive Substances 0.000 claims description 8
- 230000000996 additive effect Effects 0.000 claims description 8
- 229930182817 methionine Natural products 0.000 claims description 8
- 239000011780 sodium chloride Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 241001441723 Takifugu Species 0.000 claims description 5
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 229920000881 Modified starch Polymers 0.000 claims description 4
- 239000004368 Modified starch Substances 0.000 claims description 4
- 229910017053 inorganic salt Inorganic materials 0.000 claims description 4
- 235000019426 modified starch Nutrition 0.000 claims description 4
- 239000005022 packaging material Substances 0.000 claims description 4
- PWVXXGRKLHYWKM-UHFFFAOYSA-N 5-[2-(benzenesulfonyl)ethyl]-3-[(1-methylpyrrolidin-2-yl)methyl]-1h-indole Chemical compound CN1CCCC1CC(C1=C2)=CNC1=CC=C2CCS(=O)(=O)C1=CC=CC=C1 PWVXXGRKLHYWKM-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 11
- 238000010521 absorption reaction Methods 0.000 abstract description 9
- 229940079593 drug Drugs 0.000 abstract description 9
- 241001465754 Metazoa Species 0.000 abstract description 8
- 230000009286 beneficial effect Effects 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 239000007787 solid Substances 0.000 abstract description 4
- 206010067482 No adverse event Diseases 0.000 abstract description 3
- 229920002472 Starch Polymers 0.000 abstract description 3
- 239000000969 carrier Substances 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 abstract description 3
- 150000001875 compounds Chemical class 0.000 abstract description 3
- 238000009826 distribution Methods 0.000 abstract description 3
- 235000019698 starch Nutrition 0.000 abstract description 3
- 239000008107 starch Substances 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- 239000011159 matrix material Substances 0.000 abstract description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- -1 premix Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/22—Compounds of alkali metals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Animal Husbandry (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Insects & Arthropods (AREA)
- Marine Sciences & Fisheries (AREA)
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Abstract
The application discloses a preparation method of water-soluble auxiliary agent for veterinary drugs, aquatic products and feed additives, which comprises the following steps: selecting materials; dissolving at high temperature; cooling and agglomerating; crushing; drying at high temperature; and (6) packaging. The application has the beneficial effects that: the compound prepared by high-temperature treatment of soluble starch and other special carriers has the characteristics of good stability, high solubility in water, uniform color, low possibility of moisture absorption and no agglomeration, has strong adsorbability and affinity, has a slow-release synergistic effect, can be used as a matrix auxiliary material of powder, premix and solid agent, can increase the solubility and the dissolution rate of a main drug, is beneficial to the absorption and distribution of the drug in an animal body, is safe, reliable and stable, has no adverse reaction to the animal, and has great help for improving the absorption, utilization and curative effect of the drug.
Description
Technical Field
The application relates to a preparation method of an auxiliary agent, in particular to a preparation method of a water-soluble auxiliary agent for veterinary drugs, aquatic products and feed additives.
Background
The mixed feed is prepared by simply processing and mixing various feed raw materials, is a primary mixed feed, mainly considers the nutritional indexes such as energy, protein, calcium, phosphorus and the like, is common in many rural areas, can be used for directly feeding animals, has higher effect than common feeds, and has the advantages of high feeding and growth speed, easy occurrence of diseases and poor resistance.
In the animal medicine and aquatic product industries, due to the problem of a carrier, medicaments such as powder, premix, solid disinfectant and the like in production have some problems in a plurality of pharmaceutical factories in China at present, such as short product storage period, unstable property, moisture regain and agglomeration, color change or poor dissolving performance, and the like, and due to the problems, the complaint rate of end customers and distributors is increased and unnecessary waste and loss are caused. Therefore, the preparation method of the water-soluble auxiliary agent for veterinary drugs, aquatic products and feed additives is provided for solving the problems.
Disclosure of Invention
A preparation method of a water-soluble auxiliary agent for veterinary drugs, aquatic products and feed additives comprises the following steps:
s1, selecting materials: various mineral substances, inorganic salt, modified starch and other auxiliary materials;
s2, high-temperature dissolution: pouring the mixture into a high-temperature dissolving container filled with the solution, and stirring and dissolving the mixture into a paste state by using stirring equipment;
s3, cooling and agglomerating: mixing the paste by using cooling equipment, and performing low-temperature cooling agglomeration;
s4, crushing: orderly pouring the cooled lumps into crushing equipment in batches for crushing;
s5, high-temperature drying: conveying the crushed aggregates into temperature control drying equipment through conveying equipment for high-temperature drying, wherein the water content of the crushed aggregates is below 10%;
and S6, packaging by adopting a special packaging material.
Preferably, the effective various minerals in the step S1 include copper, iron, manganese, zinc, magnesium, potassium, sodium and calcium, and the mixed feed is divided into: jinmeiman I, Jinmeiman II, Fugu powder I, Meimansu I and Subu Xiaojiabao.
Preferably, the indexes of the mineral substances of Jinmeiman I are as follows: copper (mg/kg): 0. iron (mg/kg): 0. manganese (mg/kg): 0. zinc (mg/kg): 0. magnesium (%): 0.5-10, potassium (mg/kg): 0. sodium (%): 4-35, calcium (mg/kg): 0.
preferably, the indexes of the mineral substances of the Jinmeiman II are as follows: copper (mg/kg): 50-1400, iron (mg/kg): 100, 3500, manganese (mg/kg): 60-3000, zinc (mg/kg): 150-: 0.5-10, potassium (mg/kg): 0. sodium (%): 4-35, calcium (mg/kg): 0.
preferably, the indexes of the first mineral substances of the state-righting powder are as follows: copper (mg/kg): 0. iron (mg/kg): 0. manganese (mg/kg): 0. zinc (mg/kg): 0. magnesium (%): 0.5-13, potassium (mg/kg): 0. sodium (%): 3-32, calcium (mg/kg): 0.
preferably, the indexes of the minerals of the first meizanol are as follows: copper (mg/kg): 0. iron (mg/kg): 0. manganese (mg/kg): 0. zinc (mg/kg): 0. magnesium (%): 0.5-13, potassium (mg/kg): 0. sodium (%): 5-27, calcium (mg/kg): 0.
preferably, the indexes of each mineral substance of the quick-repair hard shell treasure are as follows: copper (mg/kg): 0. iron (mg/kg): 2000-8000, manganese (mg/kg): 5000-: 4000-: 1-3, potassium (mg/kg): 1600. sodium (%): 1-17, calcium (mg/kg): 600.
preferably, the second Jinmeiman component also comprises lysine, methionine and addition amount, and the lysine, the methionine and the addition amount are respectively 500mg/kg, 20-1000mg/kg and 1%.
Preferably, the quick-repair hard shell treasure composition further comprises sodium chloride and an addition amount, wherein the sodium chloride and the addition amount are 5-17% and 0.5% respectively.
Preferably, the net weight of each bag in the step S6 is: 0.1 kg, 0.2 kg, 0.5 kg, 1.0 kg, 2.0 kg, 5.0 kg, 10 kg, 20 kg, 25 kg.
The invention has the beneficial effects that: the compound prepared by high-temperature treatment of various inorganic salts, soluble starch and other special carriers has the characteristics of good stability, high solubility in water (the water solubility saturation can reach 25%), high clarity of the water solution, strong product fluidity, uniform color, difficult moisture absorption, no caking and the like, has strong adsorbability and affinity, has a slow-release synergistic effect, can be used as a substrate auxiliary material of powder, a premix and a solid agent, can increase the solubility and the dissolution rate of a main drug, is beneficial to the absorption and distribution of the drug in an animal body, is safe, reliable and stable, has no adverse reaction to the animal, and is greatly helpful for improving the absorption, utilization and curative effect of the drug.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without inventive exercise.
FIG. 1 is a flow chart of the preparation method of the present application.
Detailed Description
In order to make the technical solutions better understood by those skilled in the art, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only partial embodiments of the present application, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
It should be noted that the terms "first," "second," and the like in the description and claims of this application and in the drawings described above are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It should be understood that the data so used may be interchanged under appropriate circumstances such that embodiments of the application described herein may be used. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
In this application, the terms "upper", "lower", "left", "right", "front", "rear", "top", "bottom", "inner", "outer", "middle", "vertical", "horizontal", "lateral", "longitudinal", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings. These terms are used primarily to better describe the present application and its embodiments, and are not used to limit the indicated devices, elements or components to a particular orientation or to be constructed and operated in a particular orientation.
Moreover, some of the above terms may be used to indicate other meanings besides the orientation or positional relationship, for example, the term "on" may also be used to indicate some kind of attachment or connection relationship in some cases. The specific meaning of these terms in this application will be understood by those of ordinary skill in the art as appropriate.
Furthermore, the terms "mounted," "disposed," "provided," "connected," and "sleeved" are to be construed broadly. For example, it may be a fixed connection, a removable connection, or a unitary construction; can be a mechanical connection, or an electrical connection; may be directly connected, or indirectly connected through intervening media, or may be in internal communication between two devices, elements or components. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as appropriate.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to the embodiments with reference to the attached drawings.
The first embodiment is as follows:
the preparation method of the veterinary drug, the aquatic product, the feed additive and the water-soluble auxiliary agent comprises the following steps:
s1, selecting materials: various mineral substances, inorganic salt, modified starch and other auxiliary materials;
s2, high-temperature dissolution: pouring the mixture into a high-temperature dissolving container filled with the solution, and stirring and dissolving the mixture into a paste state by using stirring equipment;
s3, cooling and agglomerating: mixing the paste by using cooling equipment, and performing low-temperature cooling agglomeration;
s4, crushing: orderly pouring the cooled lumps into crushing equipment in batches for crushing;
s5, high-temperature drying: conveying the crushed aggregates into temperature control drying equipment through conveying equipment for high-temperature drying, wherein the water content of the crushed aggregates is below 10%;
and S6, packaging by adopting a special packaging material.
Further, the effective various minerals in the step S1 include copper, iron, manganese, zinc, magnesium, potassium, sodium and calcium, and the mixed feed is divided into: jinmeiman I, Jinmeiman II, Fugu powder I, Meimansu I and Subu Xiaojiabao.
Further, the indexes of the mineral substances of Jinmeiman I are as follows: magnesium (%): 0.5, sodium (%): 4.
further, the indexes of the mineral substances of the Jinmeiman II are as follows: copper (mg/kg): 50. iron (mg/kg): 100. manganese (mg/kg): 60. zinc (mg/kg): 150. magnesium (%): 0.5, sodium (%): 4.
further, the indexes of the first state-supporting powder for various mineral substances are as follows: magnesium (%): 0.5, sodium (%): 3.
further, each mineral index of the first meinain is as follows: magnesium (%): 0.5, sodium (%): 5.
further, the indexes of various mineral substances of the quick-repair hard shell treasure are as follows: iron (mg/kg): 2000. manganese (mg/kg): 5000. zinc (mg/kg): 4000. magnesium (%): 1. potassium (mg/kg): 1600. sodium (%): 1. calcium (mg/kg): 600.
furthermore, the second Jinmeiman component also comprises lysine, methionine and additive amount, wherein the lysine, the methionine and the additive amount are respectively 500mg/kg, 20mg/kg and 1%.
Furthermore, the quick-repair hard shell cleaner also comprises sodium chloride and an addition amount, wherein the sodium chloride and the addition amount are respectively 5% and 0.5%.
Further, the net weight of each bag in the step S6 is: 0.1 kg, 0.2 kg, 0.5 kg, 1.0 kg, 2.0 kg, 5.0 kg, 10 kg, 20 kg, 25 kg.
The compound prepared by high-temperature treatment of various inorganic salts, soluble starch and other special carriers has the characteristics of good stability, high water solubility (the water saturation can reach 25%), high clarity of the water solution, strong product fluidity, uniform color, low moisture absorption possibility, no caking and the like.
Example two:
s1, selecting materials: various mineral substances, inorganic salt, modified starch and other auxiliary materials;
s2, high-temperature dissolution: pouring the mixture into a high-temperature dissolving container filled with the solution, and stirring and dissolving the mixture into a paste state by using stirring equipment;
s3, cooling and agglomerating: mixing the paste by using cooling equipment, and performing low-temperature cooling agglomeration;
s4, crushing: orderly pouring the cooled lumps into crushing equipment in batches for crushing;
s5, high-temperature drying: conveying the crushed aggregates into temperature control drying equipment through conveying equipment for high-temperature drying, wherein the water content of the crushed aggregates is below 10%;
and S6, packaging by adopting a special packaging material.
Further, the effective various minerals in the step S1 include copper, iron, manganese, zinc, magnesium, potassium, sodium and calcium, and the mixed feed is divided into: jinmeiman I, Jinmeiman II, Fugu powder I, Meimansu I and Subu Xiaojiabao.
Further, the indexes of the mineral substances of Jinmeiman I are as follows: magnesium (%): 10. sodium (%): 35.
further, the indexes of the mineral substances of the Jinmeiman II are as follows: copper (mg/kg): 1400. iron (mg/kg): 3500. manganese (mg/kg): 3000. zinc (mg/kg): 4500. magnesium (%): 10. sodium (%): 35.
further, the indexes of the first state-supporting powder for various mineral substances are as follows: magnesium (%): 13. sodium (%): 32.
further, each mineral index of the first meinain is as follows: magnesium (%): 13. sodium (%): 27.
further, the indexes of various mineral substances of the quick-repair hard shell treasure are as follows: iron (mg/kg): 8000. manganese (mg/kg): 15000. zinc (mg/kg): 15000. magnesium (%): 3. potassium (mg/kg): 1600. sodium (%): 17. calcium (mg/kg): 600.
furthermore, the second Jinmeiman component also comprises lysine, methionine and additive amount, wherein the lysine, the methionine and the additive amount are respectively 500mg/kg, 1000mg/kg and 1%.
Furthermore, the quick-repair hard shell cleaner also comprises sodium chloride and an addition amount, wherein the sodium chloride and the addition amount are respectively 17% and 0.5%.
Further, the net weight of each bag in the step S6 is: 0.1 kg, 0.2 kg, 0.5 kg, 1.0 kg, 2.0 kg, 5.0 kg, 10 kg, 20 kg, 25 kg.
Example three:
the effective various mineral substances in the step S1 comprise copper, iron, manganese, zinc, magnesium, potassium, sodium and calcium, and the mixed feed is divided into the following components according to the indexes of various mineral substances: jinmeiman I, Jinmeiman II, Fugu powder I, Meimansu I and Subu Xiaojiabao; the indexes of various minerals of Jinmeiman I are as follows: magnesium (%): 10. sodium (%): 35; the indexes of the mineral substances of the Jinmeiman II are as follows: copper (mg/kg): 1400. iron (mg/kg): 3500. manganese (mg/kg): 3000. zinc (mg/kg): 4500. magnesium (%): 10. sodium (%): 35; the indexes of the first state supporting powder for various mineral substances are as follows: magnesium (%): 13. sodium (%): 32, a first step of removing the first layer; the indexes of various minerals of the first meizanol are as follows: magnesium (%): 13. sodium (%): 27; the indexes of various mineral substances of the quick-repair hard-shell treasure are as follows: iron (mg/kg): 8000. manganese (mg/kg): 15000. zinc (mg/kg): 15000. magnesium (%): 3. potassium (mg/kg): 1600. sodium (%): 17. calcium (mg/kg): 600.
the product produced by the preparation method has stronger adsorbability and affinity, has slow-release synergistic effect, can be used as a matrix auxiliary material of powder, premix and solid agent, can increase the solubility and the dissolution rate of the main drug, is beneficial to the absorption and distribution of the drug in an animal body, is safe, reliable and stable, has no adverse reaction to the animal, and is greatly helpful for improving the absorption, utilization and curative effect of the drug.
The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims (10)
1. A preparation method of a water-soluble auxiliary agent for veterinary drugs, aquatic products and feed additives is characterized by comprising the following steps: the preparation method of the veterinary drug, the aquatic product, the feed additive and the water-soluble auxiliary agent comprises the following steps:
s1, selecting materials: various mineral substances, inorganic salt, modified starch and other auxiliary materials;
s2, high-temperature dissolution: pouring the mixture into a high-temperature dissolving container filled with the solution, and stirring and dissolving the mixture into a paste state by using stirring equipment;
s3, cooling and agglomerating: mixing the paste by using cooling equipment, and performing low-temperature cooling agglomeration;
s4, crushing: orderly pouring the cooled lumps into crushing equipment in batches for crushing;
s5, high-temperature drying: conveying the crushed aggregates into temperature control drying equipment through conveying equipment for high-temperature drying, wherein the water content of the crushed aggregates is below 10%;
and S6, packaging by adopting a special packaging material.
2. The method for preparing the water-soluble auxiliary agent for veterinary drugs, aquatic products and feed additives according to claim 1, wherein the water-soluble auxiliary agent comprises the following components in percentage by weight: the effective various mineral substances in the step S1 comprise copper, iron, manganese, zinc, magnesium, potassium, sodium and calcium, and the mixed feed is divided into the following components according to the indexes of various mineral substances: jinmeiman I, Jinmeiman II, Fugu powder I, Meimansu I and Subu Xiaojiabao.
3. The method for preparing the water-soluble auxiliary agent for veterinary drugs, aquatic products and feed additives according to claim 2, wherein the water-soluble auxiliary agent comprises the following components in percentage by weight: the indexes of various minerals of Jinmeiman I are as follows: copper (mg/kg): 0. iron (mg/kg): 0. manganese (mg/kg): 0. zinc (mg/kg): 0. magnesium (%): 0.5-10, potassium (mg/kg): 0. sodium (%): 4-35, calcium (mg/kg): 0.
4. the method for preparing the water-soluble auxiliary agent for veterinary drugs, aquatic products and feed additives according to claim 2, wherein the water-soluble auxiliary agent comprises the following components in percentage by weight: the indexes of the mineral substances of the Jinmeiman II are as follows: copper (mg/kg): 50-1400, iron (mg/kg): 100, 3500, manganese (mg/kg): 60-3000, zinc (mg/kg): 150-: 0.5-10, potassium (mg/kg): 0. sodium (%): 4-35, calcium (mg/kg): 0.
5. the method for preparing the water-soluble auxiliary agent for veterinary drugs, aquatic products and feed additives according to claim 2, wherein the water-soluble auxiliary agent comprises the following components in percentage by weight: the indexes of the first state supporting powder for various mineral substances are as follows: copper (mg/kg): 0. iron (mg/kg): 0. manganese (mg/kg): 0. zinc (mg/kg): 0. magnesium (%): 0.5-13, potassium (mg/kg): 0. sodium (%): 3-32, calcium (mg/kg): 0.
6. the method for preparing the water-soluble auxiliary agent for veterinary drugs, aquatic products and feed additives according to claim 2, wherein the water-soluble auxiliary agent comprises the following components in percentage by weight: the indexes of various minerals of the first meizanol are as follows: copper (mg/kg): 0. iron (mg/kg): 0. manganese (mg/kg): 0. zinc (mg/kg): 0. magnesium (%): 0.5-13, potassium (mg/kg): 0. sodium (%): 5-27, calcium (mg/kg): 0.
7. the method for preparing the water-soluble auxiliary agent for veterinary drugs, aquatic products and feed additives according to claim 2, wherein the water-soluble auxiliary agent comprises the following components in percentage by weight: the indexes of various mineral substances of the quick-repair hard-shell treasure are as follows: copper (mg/kg): 0. iron (mg/kg): 2000-8000, manganese (mg/kg): 5000-: 4000-: 1-3, potassium (mg/kg): 1600. sodium (%): 1-17, calcium (mg/kg): 600.
8. the method for preparing a water-soluble auxiliary agent for veterinary drugs, aquatic products and feed additives according to claim 3, wherein the water-soluble auxiliary agent comprises the following components: the second component of the chlormequat chloride also comprises lysine, methionine and additive amount, wherein the lysine, the methionine and the additive amount are respectively 500mg/kg, 20-1000mg/kg and 1%.
9. The method for preparing a water-soluble auxiliary agent for veterinary drugs, aquatic products and feed additives according to claim 7, wherein the water-soluble auxiliary agent comprises: the quick-repair hard shell cleaner also comprises sodium chloride and additive amount, wherein the sodium chloride and the additive amount are respectively 5-17% and 0.5%.
10. The method for preparing the water-soluble auxiliary agent for veterinary drugs, aquatic products and feed additives according to claim 1, wherein the water-soluble auxiliary agent comprises the following components in percentage by weight: and in the step S6, the net weight of each bag is respectively as follows: 0.1 kg, 0.2 kg, 0.5 kg, 1.0 kg, 2.0 kg, 5.0 kg, 10 kg, 20 kg, 25 kg.
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