CN101253931A - Composite anti-caking agent and method of preparing the same - Google Patents
Composite anti-caking agent and method of preparing the same Download PDFInfo
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- CN101253931A CN101253931A CNA2008100273287A CN200810027328A CN101253931A CN 101253931 A CN101253931 A CN 101253931A CN A2008100273287 A CNA2008100273287 A CN A2008100273287A CN 200810027328 A CN200810027328 A CN 200810027328A CN 101253931 A CN101253931 A CN 101253931A
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- caking
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- loose
- caking agent
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Abstract
The invention relates to a composite anti-blocking agent for livestock and poultry supplies, such as animal drugs and feed additives, and a preparation method thereof, and belongs to the field of surface active agents. The composite anti-blocking agent is characterized in that the agent comprises anhydrous magnesium sulfate, anhydrous sodium sulphate, soluble starch, isatis-root granules, dry ginger powder, and dechlorination sodium sulfate, with mass ratio of (1-3) : (1-5) : (0.5-2) : (3-5): (3-5) : (0.5-2). The composite anti-blocking agent has the advantages of stable property, good water-solubility, good liquidity, non-moisture absorption and anti-blocking property. Powder agents and premix agents with the composite anti-blocking agents as substrates increase the solubility and the dissolution rate of main drugs, thereby facilitating absorption and distribution of the drugs in animal bodies, improving bioavailability of the drugs and increasing curative effect. The preparation method has the advantages of simple process, convenient operation and environmental friendliness, and can produce products with high purity and high yield.
Description
[technical field]
The present invention relates to a kind of composite anti-caking agent that is used for livestock and poultry articles for use such as veterinary drug and feed addictive, belong to the surfactant field.
[background technology]
A large amount of use additives in livestock and poultry medicine and the feed, but the multiple additives hygroscopicity that uses is strong, and very easily caking brings very big inconvenience to production, also causes enormous economic loss simultaneously, may influence the activity of active ingredient in medicine and the feed in addition.
[summary of the invention]
The present invention aims to provide a kind of livestock and poultry articles for use such as veterinary drug and feed addictive that are used for, and effectively protection against the tide, agglomeration resistance improve the bioavailability of medicine, the composite anti-caking agent of increase curative effect simultaneously.
In addition, the present invention also provides a kind of simple and easy method for preparing above-mentioned composite anti-caking agent.
Composite anti-caking agent of the present invention, contain anhydrous magnesium sulfate, glauber salt, soluble starch, banlangen granules, banlangen keli, ginger powder, dechlorination sodium sulphate, its mass ratio is 1-3: 1-5: 0.5-2: 3-5: 3-5: 0.5-2, and preferred mass ratio is 1: 2: 1: 2.5: 2.5: 1.
A kind of method for preparing above-mentioned composite anti-caking agent comprises:
(1) mixes anhydrous magnesium sulfate, glauber salt, banlangen granules, banlangen keli, ginger powder, add the deionized water of 1-2 times of mixture quality;
(2) 65 ℃ were heated 2 hours;
(3) elimination filter residue adds soluble starch and dechlorination sodium sulphate in filtrate, stir it is fully dissolved;
(4) drying after the solution concentration is obtained solid.
Composite anti-caking agent of the present invention, stable in properties, good water solubility, mobile good, be difficult for moisture absorption, do not lump.With described composite anti-caking agent is pulvis, the pre-mixing agent of matrix, and the solubility of main ingredient and molten speed increase, and help medicine absorption and distribution in animal body, and bioavailability and the increase curative effect that improves medicine had bigger effect.
Preparation method of the present invention, the product that process is simple, easy to operate, can obtain the high-purity high yield, and also pollution-free to environment.
[specific embodiment]
Embodiment one: anti-caking agent I
(1) mixes 1 ton of anhydrous magnesium sulfate, 1 ton of glauber salt, 3 tons of banlangen granules, banlangen kelis, 3 tons of ginger powders, add 16 tons of deionized waters;
(2) 65 ℃ were heated 2 hours;
(3) elimination filter residue adds 0.5 ton of soluble starch and 0.5 ton of dechlorination sodium sulphate in filtrate, stir it is fully dissolved;
(4) with spray-drying after the solution concentration, obtain the composite anti-caking agent of 8.97 tons of dryings, its parameters sees Table 1.
Embodiment two: anti-caking agent II
(1) mixes 3 tons of anhydrous magnesium sulfates, 5 tons of glauber salt, 5 tons of banlangen granules, banlangen kelis, 5 tons of ginger powders, add 20 tons of deionized waters;
(2) 65 ℃ were heated 2 hours;
(3) elimination filter residue adds 2 tons of soluble starches and 2 tons of dechlorination sodium sulphate in filtrate, stir it is fully dissolved;
(4) with spray-drying after the solution concentration, obtain the composite anti-caking agent of 18.98 tons of dryings, its parameters sees Table 1.
Embodiment three: anti-caking agent III
(1) mixes 1 ton of anhydrous magnesium sulfate, 2 tons of glauber salt, 2.5 tons of banlangen granules, banlangen kelis, 2.5 tons of ginger powders, add 15 tons of deionized waters;
(2) 65 ℃ were heated 2 hours;
(3) elimination filter residue adds 1 ton of soluble starch and 1 ton of dechlorination sodium sulphate in filtrate, stir it is fully dissolved;
(4) with spray-drying after the solution concentration, obtain the composite anti-caking agent of 9.99 tons of dryings, its parameters sees Table 1.
The parameters of table 1 anticaking agent
| Anti-caking agent I | Anti-caking agent II | Anti-caking agent III | |
| Loss on drying (%) | ＜0.9 | ＜1 | ＜0.5 |
| Calcination loss (%) | ＜5 | ＜5 | ＜3 |
| PH (25 ℃ of 5% solution) | 6.5 | 6.8 | 7 |
| Average grain diameter (micron) | 1.2 | 1 | 0.8 |
| Specific area (m 2/g) | 2000 | 2200 | 2600 |
| Chloride (%) | ＜0.005 | ＜0.005 | ＜0.005 |
| Nitrate (%) | ＜0.0005 | ＜0.0005 | ＜0.0005 |
| Arsenic (%) | ＜0.0001 | ＜0.0001 | ＜0.0001 |
| Iron (%) | ＜0.005 | ＜0.005 | ＜0.005 |
| Heavy metal (%) | ＜0.001 | ＜0.001 | ＜0.001 |
Embodiment four: anti-caking test I
Take by weighing the additive or the medicine of equal in quality, add the anti-caking agent of 300g/kg respectively, mend and add water to same quality, placed wetting 2 hours.Under similarity condition, dry, reach the identical requirement of moisture substantially to equal in quality.Be transferred to while hot in the thick plastic bag, seal immediately under 60 ℃, place on the floor, leveling is whole, and the weighting material equilibrium is taken out after pressing certain hour, observes the caking situation, investigates caking hardness and broken piece difficulty or ease.Each sample equality presses 3 bags of samples.The results are shown in Table 2.
The anti-caking test of table 2 I II III IV V VI VII
| Commercial anti agglomeration agent I | Commercial anti agglomeration agent II | Commercial anti agglomeration agent III | Anti-caking agent I | Anti-caking agent II | Anti-caking agent III |
| Corn flour | Caking, more loose | Caking, harder | Caking, harder | There is not caking, more loose | There is not caking, more loose | There is not caking, loose |
| The methionine powder | Caking, harder | Caking, harder | Caking, more loose | There is not caking, more loose | There is not caking, more loose | There is not caking, loose |
| Oxide powder and zinc | Caking, harder | Caking, more loose | Caking, harder | There is not caking, more loose | There is not caking, more loose | There is not caking, loose |
| The azithromycin powder | Caking, harder | Caking, more loose | Caking, harder | There is not caking, more loose | There is not caking, more loose | There is not caking, loose |
| The cyromazine crystal | Caking, harder | Caking, more loose | Caking, harder | There is not caking, more loose | There is not caking, more loose | There is not caking, loose |
The result shows, after each composition adds composite anti-caking agent of the present invention, and can effective moistureproof agglomeration resistance.
Embodiment five: anti-caking test II
The anti-caking agent pack is sealed, place on the floor, leveling is whole, and the weighting material equilibrium is taken out after pressing certain hour, observes the caking situation, investigates caking hardness and broken piece difficulty or ease.Each sample equality presses 3 bags of samples.The results are shown in Table 3.
The anti-caking test of table 3 II
| Press the time | Commercial anti agglomeration agent I | Anti-caking agent I | Anti-caking agent II | Anti-caking agent III |
| 1 year | There is not caking, more loose | There is not caking, loose | There is not caking, loose | There is not caking, loose |
| 2 years | There is not caking, more loose | There is not caking, loose | There is not caking, loose | There is not caking, loose |
| 3 years | Caking, harder | There is not caking, loose | There is not caking, loose | There is not caking, loose |
| 4 years | Caking, very hard | There is not caking, more loose | There is not caking, more loose | There is not caking, loose |
| 5 years | Caking, very hard | There is not caking, more loose | There is not caking, more loose | There is not caking, loose |
The result shows that anticaking agent of the present invention can be sealed up for safekeeping and not lump in 5 years, and is better mobile.
Embodiment six: anti-caking agent is to the influence of veterinary drug effect
From the pig that suffers from asthma, choose body weight and developmental phase with near 30, be divided into three groups at random, intramuscular injection long-acting terramycin powder-injection, 30 mg/kg body weight, every day 1 time.Wherein do not add anti-caking agent in the terramycin powder injection of A group, the B group is added commercial anti agglomeration agent I (addition is 0.3%), and the C group is added anti-caking agent I (addition is 0.3%).
After three days, A group improvement rate is 30%, B group improvement rate is 40%, C group improvement rate is 80%;
After seven days, A group cure rate is 70%, B group cure rate is 75%, C group cure rate is 90%.
The result shows that anticaking agent of the present invention can effectively promote the biological transformation ratio of medicine, improves drug effect.
Embodiment seven: anti-caking agent is to the influence of feed addictive effect
150 similar young chickens of growing state are divided into three groups at random, the A group is added 0.2 Choline Chloride (do not contain anti-caking agent and contain 0.3% anti-caking agent I) in feed, the B group is added 0.2 Choline Chloride (containing 0.3% commercial anti agglomeration agent I) in feed, the C group is added 0.2 Choline Chloride (containing 0.3% anti-caking agent I) in feed, observe after one month result such as table 3.
Table 3 anti-caking agent is to the influence of feed addictive effect
| Eating speed | Rate of body weight gain (%) | Illness rate (%) | |
| The A group | Normally | 58 | 8 |
| The B group | Normally | 61 | 9 |
| The C group | Normally | 89 | 2 |
The result shows that anticaking agent of the present invention can effectively promote the biological transformation ratio of medicine, improves drug effect.
Claims (3)
1, a kind of composite anti-caking agent is characterized in that containing anhydrous magnesium sulfate, glauber salt, soluble starch, banlangen granules, banlangen keli, ginger powder, dechlorination sodium sulphate, and its mass ratio is 1-3: 1-5: 0.5-2: 3-5: 3-5: 0.5-2.
2, composite anti-caking agent as claimed in claim 1 is characterized in that containing anhydrous magnesium sulfate, glauber salt, soluble starch, banlangen granules, banlangen keli, ginger powder, dechlorination sodium sulphate, and its mass ratio is 1: 2: 1: 2.5: 2.5: 1.
3. method for preparing composite anti-caking agent as claimed in claim 1 is characterized in that may further comprise the steps:
(1) mixes anhydrous magnesium sulfate, glauber salt, banlangen granules, banlangen keli, ginger powder, add the deionized water of 1-2 times of mixture quality;
(2) 65 ℃ were heated 2 hours;
(3) elimination filter residue adds soluble starch and dechlorination sodium sulphate in filtrate, stir it is fully dissolved;
(4) drying after the solution concentration is obtained solid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100273287A CN101253931A (en) | 2008-04-10 | 2008-04-10 | Composite anti-caking agent and method of preparing the same |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100273287A CN101253931A (en) | 2008-04-10 | 2008-04-10 | Composite anti-caking agent and method of preparing the same |
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| CN101253931A true CN101253931A (en) | 2008-09-03 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106316189A (en) * | 2016-08-31 | 2017-01-11 | 广州协堡建材有限公司 | Damp-proof and anti-caking agent for dry-mixed mortar |
| CN106721055A (en) * | 2016-11-30 | 2017-05-31 | 杭州康德权饲料有限公司 | Feeding coating compound acidulant and preparation method thereof |
| CN109248321A (en) * | 2018-11-27 | 2019-01-22 | 广州承兴生物科技有限公司 | A kind of beasts, birds and aquatic products water-solubility carrier and preparation method thereof |
| CN111955609A (en) * | 2020-08-29 | 2020-11-20 | 广州承兴生物科技有限公司 | Preparation method of water-soluble auxiliary agent for veterinary drug, aquatic product and feed additive |
-
2008
- 2008-04-10 CN CNA2008100273287A patent/CN101253931A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106316189A (en) * | 2016-08-31 | 2017-01-11 | 广州协堡建材有限公司 | Damp-proof and anti-caking agent for dry-mixed mortar |
| CN106721055A (en) * | 2016-11-30 | 2017-05-31 | 杭州康德权饲料有限公司 | Feeding coating compound acidulant and preparation method thereof |
| CN109248321A (en) * | 2018-11-27 | 2019-01-22 | 广州承兴生物科技有限公司 | A kind of beasts, birds and aquatic products water-solubility carrier and preparation method thereof |
| CN111955609A (en) * | 2020-08-29 | 2020-11-20 | 广州承兴生物科技有限公司 | Preparation method of water-soluble auxiliary agent for veterinary drug, aquatic product and feed additive |
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Open date: 20080903 |