CN102524540B - Saving trace element compound packet as well as preparation method and application thereof - Google Patents
Saving trace element compound packet as well as preparation method and application thereof Download PDFInfo
- Publication number
- CN102524540B CN102524540B CN 201210016075 CN201210016075A CN102524540B CN 102524540 B CN102524540 B CN 102524540B CN 201210016075 CN201210016075 CN 201210016075 CN 201210016075 A CN201210016075 A CN 201210016075A CN 102524540 B CN102524540 B CN 102524540B
- Authority
- CN
- China
- Prior art keywords
- trace element
- superpacket
- sulfate
- economizing type
- zinc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000011573 trace mineral Substances 0.000 title claims abstract description 265
- 235000013619 trace mineral Nutrition 0.000 title claims abstract description 265
- 150000001875 compounds Chemical class 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims abstract description 31
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract description 144
- 241001465754 Metazoa Species 0.000 claims abstract description 75
- 239000004471 Glycine Substances 0.000 claims abstract description 72
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 56
- 229910052802 copper Inorganic materials 0.000 claims abstract description 56
- 239000010949 copper Substances 0.000 claims abstract description 56
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 51
- 239000011701 zinc Substances 0.000 claims abstract description 51
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 51
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims abstract description 44
- 229910052748 manganese Inorganic materials 0.000 claims abstract description 44
- 239000011572 manganese Substances 0.000 claims abstract description 44
- 150000001447 alkali salts Chemical class 0.000 claims abstract description 31
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims abstract description 23
- 238000001035 drying Methods 0.000 claims abstract description 19
- 229940082569 selenite Drugs 0.000 claims abstract description 15
- MCAHWIHFGHIESP-UHFFFAOYSA-L selenite(2-) Chemical compound [O-][Se]([O-])=O MCAHWIHFGHIESP-UHFFFAOYSA-L 0.000 claims abstract description 15
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims abstract description 15
- 229960001763 zinc sulfate Drugs 0.000 claims abstract description 15
- 229910000368 zinc sulfate Inorganic materials 0.000 claims abstract description 15
- 238000003756 stirring Methods 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 claims abstract description 11
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims abstract description 10
- VVYPIVJZLVJPGU-UHFFFAOYSA-L copper;2-aminoacetate Chemical compound [Cu+2].NCC([O-])=O.NCC([O-])=O VVYPIVJZLVJPGU-UHFFFAOYSA-L 0.000 claims abstract description 10
- 239000000725 suspension Substances 0.000 claims abstract description 10
- 241000282849 Ruminantia Species 0.000 claims abstract description 8
- 239000011790 ferrous sulphate Substances 0.000 claims abstract description 6
- 235000003891 ferrous sulphate Nutrition 0.000 claims abstract description 6
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims abstract description 6
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 102
- 229910052742 iron Inorganic materials 0.000 claims description 51
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 48
- 239000000203 mixture Substances 0.000 claims description 31
- 239000010941 cobalt Substances 0.000 claims description 30
- 229910017052 cobalt Inorganic materials 0.000 claims description 30
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 30
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 27
- 238000006243 chemical reaction Methods 0.000 claims description 27
- 239000011669 selenium Substances 0.000 claims description 27
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 26
- 229910052804 chromium Inorganic materials 0.000 claims description 26
- 239000011651 chromium Substances 0.000 claims description 26
- 229910052711 selenium Inorganic materials 0.000 claims description 26
- 235000019730 animal feed additive Nutrition 0.000 claims description 24
- 229910052759 nickel Inorganic materials 0.000 claims description 24
- DTGBCAFLVSFZRF-UHFFFAOYSA-N 2-aminoacetic acid;chromium Chemical compound [Cr].NCC(O)=O DTGBCAFLVSFZRF-UHFFFAOYSA-N 0.000 claims description 20
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 18
- -1 micro-basic salt Chemical compound 0.000 claims description 12
- 239000013522 chelant Substances 0.000 claims description 11
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 claims description 11
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims description 10
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 10
- 229910052732 germanium Inorganic materials 0.000 claims description 10
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims description 10
- 229910052901 montmorillonite Inorganic materials 0.000 claims description 10
- GIPOFCXYHMWROH-UHFFFAOYSA-L 2-aminoacetate;iron(2+) Chemical compound [Fe+2].NCC([O-])=O.NCC([O-])=O GIPOFCXYHMWROH-UHFFFAOYSA-L 0.000 claims description 9
- IXONOEXDSRFORV-UHFFFAOYSA-N 2-aminoacetic acid;cobalt Chemical compound [Co].NCC(O)=O.NCC(O)=O IXONOEXDSRFORV-UHFFFAOYSA-N 0.000 claims description 9
- 229940011405 cupric glycinate Drugs 0.000 claims description 9
- 229940086413 ferrous bisglycinate Drugs 0.000 claims description 9
- 229940099596 manganese sulfate Drugs 0.000 claims description 9
- 239000011702 manganese sulphate Substances 0.000 claims description 9
- 235000007079 manganese sulphate Nutrition 0.000 claims description 9
- 239000011592 zinc chloride Substances 0.000 claims description 9
- 235000005074 zinc chloride Nutrition 0.000 claims description 9
- XTEGARKTQYYJKE-UHFFFAOYSA-M Chlorate Chemical compound [O-]Cl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-M 0.000 claims description 8
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 8
- 238000007664 blowing Methods 0.000 claims description 8
- LGQLOGILCSXPEA-UHFFFAOYSA-L nickel sulfate Chemical compound [Ni+2].[O-]S([O-])(=O)=O LGQLOGILCSXPEA-UHFFFAOYSA-L 0.000 claims description 8
- 229910000008 nickel(II) carbonate Inorganic materials 0.000 claims description 8
- 229910000363 nickel(II) sulfate Inorganic materials 0.000 claims description 8
- ZULUUIKRFGGGTL-UHFFFAOYSA-L nickel(ii) carbonate Chemical compound [Ni+2].[O-]C([O-])=O ZULUUIKRFGGGTL-UHFFFAOYSA-L 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 239000004575 stone Substances 0.000 claims description 8
- 244000144972 livestock Species 0.000 claims description 7
- 238000010792 warming Methods 0.000 claims description 7
- IEOJTQSWHLGOQI-UHFFFAOYSA-L 2-aminoacetate;nickel(2+) Chemical compound [Ni+2].NCC([O-])=O.NCC([O-])=O IEOJTQSWHLGOQI-UHFFFAOYSA-L 0.000 claims description 6
- 239000003513 alkali Substances 0.000 claims description 6
- 229940116318 copper carbonate Drugs 0.000 claims description 5
- GEZOTWYUIKXWOA-UHFFFAOYSA-L copper;carbonate Chemical compound [Cu+2].[O-]C([O-])=O GEZOTWYUIKXWOA-UHFFFAOYSA-L 0.000 claims description 5
- 239000010433 feldspar Substances 0.000 claims description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 4
- QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000011575 calcium Substances 0.000 claims description 4
- KTVIXTQDYHMGHF-UHFFFAOYSA-L cobalt(2+) sulfate Chemical compound [Co+2].[O-]S([O-])(=O)=O KTVIXTQDYHMGHF-UHFFFAOYSA-L 0.000 claims description 4
- YBMRDBCBODYGJE-UHFFFAOYSA-N germanium oxide Inorganic materials O=[Ge]=O YBMRDBCBODYGJE-UHFFFAOYSA-N 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- LITQZINTSYBKIU-UHFFFAOYSA-F tetracopper;hexahydroxide;sulfate Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Cu+2].[Cu+2].[Cu+2].[Cu+2].[O-]S([O-])(=O)=O LITQZINTSYBKIU-UHFFFAOYSA-F 0.000 claims description 4
- 239000011787 zinc oxide Substances 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- 229910021380 Manganese Chloride Inorganic materials 0.000 claims description 3
- GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 claims description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 3
- 239000011565 manganese chloride Substances 0.000 claims description 3
- 235000002867 manganese chloride Nutrition 0.000 claims description 3
- 229910021503 Cobalt(II) hydroxide Inorganic materials 0.000 claims description 2
- 239000004277 Ferrous carbonate Substances 0.000 claims description 2
- 229910021586 Nickel(II) chloride Inorganic materials 0.000 claims description 2
- 229910021536 Zeolite Inorganic materials 0.000 claims description 2
- ZAQMFLLRGYSTTK-UHFFFAOYSA-N [Ge].NCC(=O)O Chemical compound [Ge].NCC(=O)O ZAQMFLLRGYSTTK-UHFFFAOYSA-N 0.000 claims description 2
- 229910021446 cobalt carbonate Inorganic materials 0.000 claims description 2
- GVPFVAHMJGGAJG-UHFFFAOYSA-L cobalt dichloride Chemical compound [Cl-].[Cl-].[Co+2] GVPFVAHMJGGAJG-UHFFFAOYSA-L 0.000 claims description 2
- 229910000428 cobalt oxide Inorganic materials 0.000 claims description 2
- ZOTKGJBKKKVBJZ-UHFFFAOYSA-L cobalt(2+);carbonate Chemical compound [Co+2].[O-]C([O-])=O ZOTKGJBKKKVBJZ-UHFFFAOYSA-L 0.000 claims description 2
- HIYNGBUQYVBFLA-UHFFFAOYSA-D cobalt(2+);dicarbonate;hexahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Co+2].[Co+2].[Co+2].[Co+2].[Co+2].[O-]C([O-])=O.[O-]C([O-])=O HIYNGBUQYVBFLA-UHFFFAOYSA-D 0.000 claims description 2
- 229910000001 cobalt(II) carbonate Inorganic materials 0.000 claims description 2
- ASKVAEGIVYSGNY-UHFFFAOYSA-L cobalt(ii) hydroxide Chemical compound [OH-].[OH-].[Co+2] ASKVAEGIVYSGNY-UHFFFAOYSA-L 0.000 claims description 2
- IVMYJDGYRUAWML-UHFFFAOYSA-N cobalt(ii) oxide Chemical compound [Co]=O IVMYJDGYRUAWML-UHFFFAOYSA-N 0.000 claims description 2
- AEJIMXVJZFYIHN-UHFFFAOYSA-N copper;dihydrate Chemical compound O.O.[Cu] AEJIMXVJZFYIHN-UHFFFAOYSA-N 0.000 claims description 2
- 229960004643 cupric oxide Drugs 0.000 claims description 2
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 2
- FNIHDXPFFIOGKL-UHFFFAOYSA-N disodium;dioxido(oxo)germane Chemical compound [Na+].[Na+].[O-][Ge]([O-])=O FNIHDXPFFIOGKL-UHFFFAOYSA-N 0.000 claims description 2
- 235000019268 ferrous carbonate Nutrition 0.000 claims description 2
- RAQDACVRFCEPDA-UHFFFAOYSA-L ferrous carbonate Chemical compound [Fe+2].[O-]C([O-])=O RAQDACVRFCEPDA-UHFFFAOYSA-L 0.000 claims description 2
- 229960004652 ferrous carbonate Drugs 0.000 claims description 2
- 229960001781 ferrous sulfate Drugs 0.000 claims description 2
- 229910000015 iron(II) carbonate Inorganic materials 0.000 claims description 2
- IPJKJLXEVHOKSE-UHFFFAOYSA-L manganese dihydroxide Chemical compound [OH-].[OH-].[Mn+2] IPJKJLXEVHOKSE-UHFFFAOYSA-L 0.000 claims description 2
- PPNAOCWZXJOHFK-UHFFFAOYSA-N manganese(2+);oxygen(2-) Chemical compound [O-2].[Mn+2] PPNAOCWZXJOHFK-UHFFFAOYSA-N 0.000 claims description 2
- VASIZKWUTCETSD-UHFFFAOYSA-N manganese(II) oxide Inorganic materials [Mn]=O VASIZKWUTCETSD-UHFFFAOYSA-N 0.000 claims description 2
- QMMRZOWCJAIUJA-UHFFFAOYSA-L nickel dichloride Chemical compound Cl[Ni]Cl QMMRZOWCJAIUJA-UHFFFAOYSA-L 0.000 claims description 2
- 229910000480 nickel oxide Inorganic materials 0.000 claims description 2
- BFDHFSHZJLFAMC-UHFFFAOYSA-L nickel(ii) hydroxide Chemical compound [OH-].[OH-].[Ni+2] BFDHFSHZJLFAMC-UHFFFAOYSA-L 0.000 claims description 2
- PVADDRMAFCOOPC-UHFFFAOYSA-N oxogermanium Chemical compound [Ge]=O PVADDRMAFCOOPC-UHFFFAOYSA-N 0.000 claims description 2
- GNRSAWUEBMWBQH-UHFFFAOYSA-N oxonickel Chemical compound [Ni]=O GNRSAWUEBMWBQH-UHFFFAOYSA-N 0.000 claims description 2
- UOURRHZRLGCVDA-UHFFFAOYSA-D pentazinc;dicarbonate;hexahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Zn+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2].[O-]C([O-])=O.[O-]C([O-])=O UOURRHZRLGCVDA-UHFFFAOYSA-D 0.000 claims description 2
- 239000010457 zeolite Substances 0.000 claims description 2
- 229960001939 zinc chloride Drugs 0.000 claims description 2
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 claims description 2
- 229940007718 zinc hydroxide Drugs 0.000 claims description 2
- 229910021511 zinc hydroxide Inorganic materials 0.000 claims description 2
- 229960001296 zinc oxide Drugs 0.000 claims description 2
- 239000000463 material Substances 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 16
- 238000000034 method Methods 0.000 abstract description 15
- 241000282887 Suidae Species 0.000 abstract description 10
- 230000008569 process Effects 0.000 abstract description 10
- 239000000654 additive Substances 0.000 abstract description 6
- 230000000996 additive effect Effects 0.000 abstract description 6
- 230000008901 benefit Effects 0.000 abstract description 6
- 239000002131 composite material Substances 0.000 abstract description 3
- 238000007086 side reaction Methods 0.000 abstract description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 2
- 239000011707 mineral Substances 0.000 abstract 2
- YJYOLOWXCPIBSY-UHFFFAOYSA-L 2-aminoacetic acid;iron(2+);sulfate Chemical compound [H+].[H+].[Fe+2].NCC([O-])=O.NCC([O-])=O.[O-]S([O-])(=O)=O YJYOLOWXCPIBSY-UHFFFAOYSA-L 0.000 abstract 1
- 241000271566 Aves Species 0.000 abstract 1
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 229910000365 copper sulfate Inorganic materials 0.000 abstract 1
- 238000007599 discharging Methods 0.000 abstract 1
- 229960003573 ferrous glycine sulfate Drugs 0.000 abstract 1
- 238000005453 pelletization Methods 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 64
- 235000014590 basal diet Nutrition 0.000 description 25
- 229940091258 selenium supplement Drugs 0.000 description 25
- 230000012010 growth Effects 0.000 description 24
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 22
- 238000005516 engineering process Methods 0.000 description 20
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 16
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 15
- 239000011781 sodium selenite Substances 0.000 description 15
- 235000015921 sodium selenite Nutrition 0.000 description 15
- 229960001471 sodium selenite Drugs 0.000 description 15
- 238000010521 absorption reaction Methods 0.000 description 14
- 230000002354 daily effect Effects 0.000 description 12
- 230000006870 function Effects 0.000 description 11
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 11
- 238000004519 manufacturing process Methods 0.000 description 11
- 229910052757 nitrogen Inorganic materials 0.000 description 11
- 239000000047 product Substances 0.000 description 10
- 239000007921 spray Substances 0.000 description 10
- 235000013601 eggs Nutrition 0.000 description 9
- 230000036571 hydration Effects 0.000 description 9
- 238000006703 hydration reaction Methods 0.000 description 9
- 230000037396 body weight Effects 0.000 description 8
- 210000004051 gastric juice Anatomy 0.000 description 8
- 230000001488 breeding effect Effects 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 150000002500 ions Chemical group 0.000 description 7
- 230000004060 metabolic process Effects 0.000 description 7
- 241000251468 Actinopterygii Species 0.000 description 6
- 241000252233 Cyprinus carpio Species 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- 238000009395 breeding Methods 0.000 description 6
- UWZXJRBXKTZILP-UHFFFAOYSA-L calcium;selenite Chemical compound [Ca+2].[O-][Se]([O-])=O UWZXJRBXKTZILP-UHFFFAOYSA-L 0.000 description 6
- 244000309466 calf Species 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- ISPYRSDWRDQNSW-UHFFFAOYSA-L manganese(II) sulfate monohydrate Chemical compound O.[Mn+2].[O-]S([O-])(=O)=O ISPYRSDWRDQNSW-UHFFFAOYSA-L 0.000 description 6
- 235000016709 nutrition Nutrition 0.000 description 6
- RNZCSKGULNFAMC-UHFFFAOYSA-L zinc;hydrogen sulfate;hydroxide Chemical compound O.[Zn+2].[O-]S([O-])(=O)=O RNZCSKGULNFAMC-UHFFFAOYSA-L 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 5
- 230000008485 antagonism Effects 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- JZCCFEFSEZPSOG-UHFFFAOYSA-L copper(II) sulfate pentahydrate Chemical compound O.O.O.O.O.[Cu+2].[O-]S([O-])(=O)=O JZCCFEFSEZPSOG-UHFFFAOYSA-L 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 5
- 235000021050 feed intake Nutrition 0.000 description 5
- 238000002372 labelling Methods 0.000 description 5
- 235000015097 nutrients Nutrition 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 239000001301 oxygen Substances 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 102000001554 Hemoglobins Human genes 0.000 description 4
- 108010054147 Hemoglobins Proteins 0.000 description 4
- 244000144987 brood Species 0.000 description 4
- 230000034994 death Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000013505 freshwater Substances 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 229910001385 heavy metal Inorganic materials 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 210000000936 intestine Anatomy 0.000 description 4
- 238000011017 operating method Methods 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 230000035790 physiological processes and functions Effects 0.000 description 4
- 238000006479 redox reaction Methods 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 238000001694 spray drying Methods 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 3
- 235000019750 Crude protein Nutrition 0.000 description 3
- 230000009056 active transport Effects 0.000 description 3
- 239000012670 alkaline solution Substances 0.000 description 3
- 208000007502 anemia Diseases 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 235000019197 fats Nutrition 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- XBDUTCVQJHJTQZ-UHFFFAOYSA-L iron(2+) sulfate monohydrate Chemical compound O.[Fe+2].[O-]S([O-])(=O)=O XBDUTCVQJHJTQZ-UHFFFAOYSA-L 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- 239000003053 toxin Substances 0.000 description 3
- 231100000765 toxin Toxicity 0.000 description 3
- 230000004584 weight gain Effects 0.000 description 3
- 235000019786 weight gain Nutrition 0.000 description 3
- 229940118149 zinc sulfate monohydrate Drugs 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 2
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- WAEMQWOKJMHJLA-UHFFFAOYSA-N Manganese(2+) Chemical compound [Mn+2] WAEMQWOKJMHJLA-UHFFFAOYSA-N 0.000 description 2
- 208000005374 Poisoning Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 230000000741 diarrhetic effect Effects 0.000 description 2
- 235000019621 digestibility Nutrition 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 150000002291 germanium compounds Chemical class 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000011132 hemopoiesis Effects 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000007233 immunological mechanism Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 210000004347 intestinal mucosa Anatomy 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 229910001437 manganese ion Inorganic materials 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- 229910052753 mercury Inorganic materials 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- 230000001850 reproductive effect Effects 0.000 description 2
- 150000003839 salts Chemical group 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 206010003591 Ataxia Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000283725 Bos Species 0.000 description 1
- 206010010947 Coordination abnormal Diseases 0.000 description 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 241000283074 Equus asinus Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 229920003149 Eudragit® E 100 Polymers 0.000 description 1
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 1
- 102000006587 Glutathione peroxidase Human genes 0.000 description 1
- 108700016172 Glutathione peroxidases Proteins 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 108010023302 HDL Cholesterol Proteins 0.000 description 1
- 241000282375 Herpestidae Species 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- 206010067997 Iodine deficiency Diseases 0.000 description 1
- 206010022971 Iron Deficiencies Diseases 0.000 description 1
- 241000784728 Lycaena virgaureae Species 0.000 description 1
- 241000276489 Merlangius merlangus Species 0.000 description 1
- 102000006386 Myelin Proteins Human genes 0.000 description 1
- 108010083674 Myelin Proteins Proteins 0.000 description 1
- 102000011931 Nucleoproteins Human genes 0.000 description 1
- 108010061100 Nucleoproteins Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000009569 Phosphoglucomutase Human genes 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 102000008114 Selenoproteins Human genes 0.000 description 1
- 108010074686 Selenoproteins Proteins 0.000 description 1
- 238000000944 Soxhlet extraction Methods 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 206010044278 Trace element deficiency Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 238000005276 aerator Methods 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000006053 animal diet Substances 0.000 description 1
- 235000019728 animal nutrition Nutrition 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000003260 anti-sepsis Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 239000005667 attractant Substances 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 description 1
- 229910000020 calcium bicarbonate Inorganic materials 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 230000023852 carbohydrate metabolic process Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000011748 cell maturation Effects 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000031902 chemoattractant activity Effects 0.000 description 1
- MEYVLGVRTYSQHI-UHFFFAOYSA-L cobalt(2+) sulfate heptahydrate Chemical group O.O.O.O.O.O.O.[Co+2].[O-]S([O-])(=O)=O MEYVLGVRTYSQHI-UHFFFAOYSA-L 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229910001431 copper ion Inorganic materials 0.000 description 1
- 229910000366 copper(II) sulfate Inorganic materials 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 235000019784 crude fat Nutrition 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000036750 egg laying performance Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000012173 estrus Effects 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 230000003031 feeding effect Effects 0.000 description 1
- 210000002149 gonad Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 230000009599 head growth Effects 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 210000003016 hypothalamus Anatomy 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 208000016290 incoordination Diseases 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 229940029329 intrinsic factor Drugs 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 235000006479 iodine deficiency Nutrition 0.000 description 1
- WSSMOXHYUFMBLS-UHFFFAOYSA-L iron dichloride tetrahydrate Chemical compound O.O.O.O.[Cl-].[Cl-].[Fe+2] WSSMOXHYUFMBLS-UHFFFAOYSA-L 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 235000020997 lean meat Nutrition 0.000 description 1
- 230000001592 luteinising effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 210000001501 megacaryocyte Anatomy 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229940029985 mineral supplement Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000005012 myelin Anatomy 0.000 description 1
- LVIYYTJTOKJJOC-UHFFFAOYSA-N nickel phthalocyanine Chemical compound [Ni+2].C12=CC=CC=C2C(N=C2[N-]C(C3=CC=CC=C32)=N2)=NC1=NC([C]1C=CC=CC1=1)=NC=1N=C1[C]3C=CC=CC3=C2[N-]1 LVIYYTJTOKJJOC-UHFFFAOYSA-N 0.000 description 1
- 238000005121 nitriding Methods 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 210000001711 oxyntic cell Anatomy 0.000 description 1
- 108091000115 phosphomannomutase Proteins 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 230000008884 pinocytosis Effects 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 230000010181 polygamy Effects 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000022558 protein metabolic process Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000001603 reducing effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229910052716 thallium Inorganic materials 0.000 description 1
- BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Landscapes
- Fodder In General (AREA)
Abstract
The invention discloses a saving trace element compound package which mainly comprises the following components in proportion: composite glycine multi-mineral material, trace element basic salt, selenite and trace element sulfate, wherein the composite glycine multi-mineral material comprises copper glycine, ferrous glycine sulfate, zinc glycine, manganese glycine and the like; the trace element basic salt comprises basic salts corresponding to trace element copper, trace element zinc and trace element manganese; and the trace element sulfate comprises copper sulfate, ferrous sulfate, zinc sulfate, manganous sulfate and the like. The preparation method of the saving trace element compound package comprises the following steps of: adding glycine and an inorganic trace element compound into water, adjusting the pH value and raising the temperature, discharging materials after stirring and reacting, adding other raw materials for preparing a mixed suspension, finally obtaining a finished product through drying and pelletizing. The saving trace element compound package can be used as an additive for feeds of animals, such as pigs, birds, ruminants, aquatic animals, special economic animals and pets. The saving trace element compound package has the advantages of simplified process, high biological value, low additive amount, obvious growth-promoting effect, less side reaction of animals, capability of being used for a long time, safety and no drug resistance, etc.
Description
Technical field
The present invention relates to the animal feed additive field, relate in particular to a kind of compound animal fodder additive and its preparation method and application.
Background technology
Along with the raising of people's living standard and the development of aquaculture, glycine has been widely used in and has added pig starter feed, kind pig feed, broiler fodder, prawn feed and eel feed etc. as feed amino acid.Glycine has following characteristics as animal feed additive: can be used for producing protein feed; Can be used as the phagostimulant (attractant) in the feed addictive, improve animal feed intake; Can suppress hay bacillus and colibacillary breeding, play important antisepsis, reduce the diarrhea rate that piglet is caused because daily ration goes mouldy.Therefore, in animal diets, add glycine and can improve to greatest extent efficiency of feed utilization.
Trace copper can effective participation the important physiology courses such as the pigmentation of formation, keratinization and tissue of cellular oxidation, bone and connective tissue of body and the formation of spinal cord myelin, and keep normal cardiac function to have important function to body.Copper also is the essential component of some enzyme systems, and especially the metalloenzyme relevant with cellular oxidation participated in organism metabolism directly.Absorption and the function of copper and iron are closely related, can keep the eubolism of ferro element, are conducive to the synthetic and erythrocytic maturation of hemoglobin; Can also participate in the breeding activity of body by promoting hypothalamus secretion luteinising hormone-releasing hormo.
Trace elements iron is one of essential trace element of animal, is the important component part of hemoglobin.Iron is present in the red blood cell of muscle oxygen gas-supplying, or the composition of many enzymes and immune system compound, and animal absorbs required most of iron from food, and is carefully controlling iron content.Iron can participate in transportation and the storage of oxygen.Iron can also promote to grow; Increase is to the resistance of disease; Regulate tissue respiration, prevent fatigue; Consist of ferroheme, the anaemia that prevention and treatment cause because of iron deficiency; Make the red hair of animal skins bright.
Trace element zinc is one of necessary trace element of animal; likened to animal " biological element " always; since the people such as Todd in 1934 confirm first that by rat test zinc is one of necessary trace element of Animal nutrition; people find gradually; zinc is 200 various metals enzymes in the animal body; the part of hormone and insulin; can promote growing and regeneration of body; keep the eubolism of body; promote appetite; maintenance organ and property function normal; accelerate Wound healing, the protection skin health is strengthening immunologic mechanism; the aspects such as raising resistance also have great nutritive value.
The Major Nutrient physiological action of trace element manganese is as the enzyme activation factor or part in carbohydrate, lipid, protein and cholesterol metabolic.Manganese can participate in the transmission of nervus centralis media and the energy supply of axoneure, to keep the requisite material of brain eubolism function, the phenomenon such as food ration decline, decreased growth, bone are unusual if the animal manganese deficiency can cause, incoordination, slow in reacting and breeding function are unusual.In addition, thyroid synthesizing must have the enzymatic that activates manganese just can finish.Manganese ion also has much relations with chroma of hair, and the chroma of hair light then contains the manganese abundance, and the intensely dark pool of hair is manganese deficiency then.
Trace element chromium is one of essential trace element of animal, brings into play special role in the glycometabolism of human body and fat metabolism.Animal is extremely low to the absorption rate of inorganic chromium, less than 1%; And animal can reach 10%～25% to the utilization rate of Organic Chromium.The physiological function of chromium is to cooperate with other material of controlling metabolism to work.Reactive compound glycine chromium can strengthen the biological action of insulin, can by the activation phosphoglucomutase accelerate the utilization of glucose in the animal body, and impel conversion of glucose be fat.Chromium can suppress the biosynthesis of cholesterol, reduces serum total cholesterol and triacylglycerol content and increasing high density lipoprotein cholesterol level, improves the lean meat percentage of letting animals feed.Chromium content in nucleoprotein is higher, and research finds that it can promote the synthetic of RNA, and chromium also affects amino acid transhipment in vivo, promotes protein metabolism and grows.In addition, chromium can also be anti-oxidant, improves immunologic function.
Trace elements of selenium is the important component part of some antioxidases (glutathione peroxidase) and selenium-P albumen in the animal body, play in vivo the balance oxidation reduction reaction, promote sugar metabolism etc. to keep physiological function to act on normally, studies have shown that selenium has the effect that improves animal immunizing power.Selenium also is the important element of keeping the heart normal function, the heart human body is had the effect of protection and reparation.It is very capable that the heavy metals such as the mercury of selenium in body, tin, thallium, lead are combined, form the composition metal selenoprotein and detoxify, toxin expelling, thereby the opposing toxic heavy metal is to the murder by poisoning of kidney, gonad and nervous centralis.Therefore, selenium can be used as the animal feed trace mineral supplement, improves agricultural byproducts selenium content and quality.
Trace element cobalt and Cobastab
12After entering stomach, with " intrinsic factor " combination of parietal cell secretion, to prevent Cobastab
12Destroyed by enteric microorganism, thereby promote its absorption.Cobalt can also the stimulating animal body in the hemopoietic system of marrow, help animal to make red blood cell, distend the blood vessels and rubefaction, prevent anaemia.Thyroxinic synthesizing may also need cobalt, the impact that cobalt energy antagonism iodine deficiency produces.
Microelement nickel is the essential biological element of animal.Nickel participates in the activity of serum calmness and enzyme and ribonucleic acid, can activate the activity of peptase, all includes nickel on the structural stability of hormonal action and large biological molecule and in the general metabolic processes.Nickel has the effect that stimulates hematopoiesis function, can stimulate red blood cell, ferroheme and leucocyte to increase, and domestic animal lacks nickel and can cause deformity and fade.
Trace element germanium has multiple biologically active, particularly from Japanese scholars shallow well one man of virtue and ability in 1967 first synthetic have the organic germanium compounds Ge-132 of extensive pharmacologically active since, the biologically active of germanium compound has caused countries in the world scholars' very big interest.Studies show that germanium can strengthen the body metabolic function by improving iodine and trilute, TA content, and then promotes the reproductive performance of animal; Meanwhile, germanium makes the quantity of red blood cell in the blood (RBC) and hemoglobin (HB) increase the on the other hand formation of stimulating platelet cellulation (being megacaryocyte), thereby hematopoietic stimulation function on the one hand.Studies show that in a large number organic germanium is to have to promote growth of animal, anticancer, anti-oxidant, reducing blood lipid, removing free radical, improve the BA such as immunity.
Above-mentioned trace copper, iron, zinc, manganese, chromium, cobalt, selenium, nickel, germanium can not only be kept the normal physiologically active of animal by independent role, can also act synergistically to promote the absorption of other trace element and improve the physiologically active of animal.Manganese can affect and improve body to the utilization of copper.Scarce copper can increase animal to the absorption of manganese, improves the anaemia that animal is caused because lacking copper.The common participation of zinc ion and manganese ion can be anti-ageing, keeps normal physiological function, improves the breeding age of kind of livestock and poultry.Selenium has regulating and controlling effect to other trace element in body, can alleviate the toxicity of mercury, lead, arsenic.The zoopery report, selenium and zinc have synergy, can the enhanced machine body immunity function.Copper mainly exists with cupric protease and plasma cell element (CER) in animal body, affects hematopoiesis, promotes absorption and the utilization of iron, accelerates cell maturation.Copper can also play strong bone, softening blood vessel, enhancing defensive enginery function with the calcium synergy.Iron, copper, zinc synergy can strengthen immunologic mechanism, strengthen anti-disease ability, and anti-bacteria infects, and reduces the death rate of animal.
As from the foregoing, trace copper, iron, zinc, manganese, chromium, cobalt, selenium, nickel, germanium can promote mutually the absorption rate in the animal body, keep and improve some specific physiologically active in the animal body, play vital effect for the normal productive life of safeguarding and improve animal.Their insufficiency of intakes, imbalance or shortage all can cause the unusual or diseases of animal physiological in varying degrees.Yet, as the necessary trace copper of animal, iron, zinc, manganese and other trace element, the inorganic metal salt forms that adopt as animal feed additive more at present, animal absorbs these inorganic salts must pass through the various biological barrier, its absorptivity is low, and addition is large, and biological value is low, most of after ight soil is discharged contaminated environment also, the activity of other nutritional labeling in the feed (such as vitamin etc.) is had destruction.In addition, copper, iron, zinc, manganese and other trace element are of a great variety, in producing storage and transport process, be easy to each other, with feed in other composition or with airborne oxygen generation antagonism reaction and redox reaction, and then break the balance between the various trace elements in the daily ration, cause between nutritional labeling unbalance, increase the burden of animal metabolism, affect absorption and the metabolism in animal body of other nutriment, and then have influence on health and the production performance of animal, severe patient even can cause animal poisoning symptom to occur.
In addition, during micro-basic salt has and hydrochloric acid in gastric juice, astringing to arrest diarrhea and antibacterial effect.Basic salt is scarcely water-soluble; with in the hydrochloric acid in gastric juice and after; the metal ion part hydrogen sulfide that abnormal fermentation produces in intestines that discharges is combined; adjust intestines and stomach pH value; and at the water-fast sulfide diaphragm of intestinal mucosa surface of a wound formation one deck; alleviate food to the stimulation of gastrointestinal mucosa, a part is absorbed by body by the free diffusing plasma channel.In addition, the trace element ions such as copper ion are antibacterial in addition, adjust the function of colony balance in the enteron aisle.
The trace element sulfate overwhelming majority is all water-soluble, can be dissolved into inorganic microelement ion and sulfate radical under one's belt, and not need to consume hydrochloric acid in gastric juice, can make additional hydrochloric acid in gastric juice remove to digest more food, improves the digestibility of animal.And the inorganic microelement ion enters in the animal body with free diffusing plasma absorption pattern, does not need to take the passage of active transport etc., does not also need power consumption.In addition, sulfate radical can excrete in conjunction with the sulfate that generation is insoluble in water with the harmful heavy metal in the animal body, plays the effect of detoxifcation, toxin expelling.
Therefore, how better in conjunction with the advantage of above-mentioned nutritional labeling and trace element, take full advantage of the complementarity of each trace element, find a kind of reasonably combined, accurately proportioning, mix, each other or and feed in antagonism and redox reaction do not occur between other composition, can promote better animal body to the feed addictive of copper, iron, zinc, manganese and other absorption of trace elements, be the technical barrier that this area faces for a long time always.
Summary of the invention
The technical problem to be solved in the present invention is to overcome the deficiencies in the prior art, provide that a kind of work simplification, biological value are high, addition is low, short long-acting fruit obviously, the animal side reaction is few, can use for a long time and safety without drug-fast economizing type trace element superpacket, the also corresponding preparation method and application that the micro-superpacket of a kind of this economizing type is provided.
For solving the problems of the technologies described above, the technical scheme that the present invention proposes is a kind of economizing type trace element superpacket, described economizing type trace element superpacket mainly is comprised of the many ore deposits of compound glycine, micro-basic salt, selenite (being preferably sodium selenite or calcium selenite) and micro-sulfate, and the mass ratio of described selenite, the many ore deposits of compound glycine, micro-basic salt and micro-sulfate is (0.001～1): (0.01～50): (0.01～10): 1; The many ore deposits of described compound glycine comprise cupric glycinate, ferrous bisglycinate chelate, glycine zine and Mn-Gly, and described micro-basic salt comprises one or more in trace copper, zinc, manganese corresponding alkali formula chlorate, subcarbonate or the subsulfate; Described micro-sulfate comprises one or more in copper sulphate, ferrous sulfate, zinc sulfate, manganese sulfate, Ge(SO), cobaltous sulfate, the nickelous sulfate.
The said goods effective integration of the present invention the many ore deposits of compound glycine, micro-basic salt and micro-sulfate three's advantage, the many ore deposits of compound glycine can enter in the body in modes such as pinocytosis, active transport, little to the stomach stimulation, make the body energy absorb simultaneously and better other trace elements such as glycine and copper, iron, zinc, manganese; During basic salt has and hydrochloric acid in gastric juice, astringing to arrest diarrhea and antibacterial effect, basic salt is scarcely water-soluble, with in the hydrochloric acid in gastric juice and after, the trace element ion part hydrogen sulfide that abnormal fermentation produces in intestines that discharges is combined, adjust intestines and stomach pH value, and at the water-fast sulfide diaphragm of intestinal mucosa surface of a wound formation one deck, alleviating food to the stimulation of gastrointestinal mucosa, a part is absorbed by body by the free diffusing plasma channel; And the sulfate overwhelming majority is all water-soluble, can be dissolved into inorganic microelement ion and sulfate radical under one's belt, and does not need to consume hydrochloric acid in gastric juice, can make additional hydrochloric acid in gastric juice remove to digest more food, improves the digestibility of animal.And the inorganic microelement ion enters in the body with free diffusing plasma absorption pattern, does not need to take the passage of active transport etc., does not also need power consumption.In addition, sulfate radical can also excrete in conjunction with the sulfate that generation is insoluble in water with the harmful heavy metal in the animal body, plays the effect of detoxifcation, toxin expelling.Economizing type of the present invention trace element superpacket can be diluted to any concentration or granulation is ground into arbitrary size according to different customer requirements, various trace elements synergy in this economizing type trace element superpacket, each trace element each other or and feed in antagonism reaction or redox reaction can not occur between other nutritional labeling, the effect of its Synergistic is very remarkable; Owing to added a certain proportion of sulfate, guaranteeing to have under the prerequisite of constructed effect, economizing type trace element superpacket of the present invention can also significantly reduce the production cost of enterprise.
In the above-mentioned economizing type trace element superpacket, described economizing type trace element superpacket is preferably fowl, and (special economic animal is wild domestication success with economizing type trace element superpacket with economizing type trace element superpacket, special economic animal with economizing type trace element superpacket, aquatic livestock with economizing type trace element superpacket, ruminant with economizing type trace element superpacket, pig, but the animal of extensively not using aborning is such as donkey, bear, masked civet etc.) or pet economizing type trace element superpacket.
Described fowl is preferably (0.1～35) with the mass ratio of copper, iron, zinc, manganese in the economizing type trace element superpacket: (15～750): (5～150): (10～150);
Described pig is preferably (1～200) with the mass ratio of copper, iron, zinc, manganese in the economizing type trace element superpacket: (15～750): (10～200): (8～150);
Described ruminant is preferably (0.1～35) with the mass ratio of copper, iron, zinc, manganese in the economizing type trace element superpacket: (10～750): (3～150): (10～150);
Described aquatic livestock is preferably (0.1～25) with the mass ratio of copper, iron, zinc, manganese in the economizing type trace element superpacket: (20～750): (15～200): (2～100);
Described special economic animal is (3～200) with the mass ratio of copper, iron, zinc, manganese in the economizing type trace element superpacket: (30～1250): (20～250): (10～150);
Described pet is preferably (3～200) with the mass ratio of copper, iron, zinc, manganese in the economizing type trace element superpacket: (30～1250): (20～250): (10～150).
Above-mentioned economizing type trace element superpacket is preferably granular preparation, also can include carrier in the described economizing type trace element superpacket, described carrier preferably comprises one or more in medical stone, zeolite powder, feldspar powder, talcum powder, montmorillonite, the white carbon.
In the above-mentioned economizing type trace element superpacket, the many ore deposits of described compound glycine also preferably comprise one or more in glycine chromium, cobalt glycinate, nickel glycinate, the glycine germanium.Described micro-basic salt also preferably comprises at least a in trace element cobalt, nickel, germanium corresponding alkali formula chlorate, subsulfate or the subcarbonate.The general direct form interpolation with glycine chromium of chromium element gets final product.
As a total technical conceive, the present invention also provides a kind of preparation method of above-mentioned economizing type trace element superpacket, may further comprise the steps: the raw material glycine and the inorganic microelement compound that prepare are added to the water by said ratio and order, after adjusting pH value is 3～10, be warming up to 30 ℃～100 ℃, abundant stirring reaction 0.5h～3h, pressure during reaction is 1～5 atmospheric pressure, blowing after reaction is finished, in product, add selenite (being preferably sodium selenite or calcium selenite) again, the mixture of trace element basic salt and micro-sulfate (optionally adding glycine chromium this moment), perhaps add selenite, the trace element basic salt, the mixture of trace element sulfate and carrier (optionally adding glycine chromium this moment), make homodisperse suspension, obtain economizing type trace element superpacket finally by drying and granulating; Wherein, the ratio of micro-total mole number is (3.2～0.8) in the molal quantity of described glycine and the described inorganic microelement compound: 1.
The processing method of conventional composite type feed addictive is reacted multiple glycine chelate thing monomer respectively often, after the drying, again by proportioning with multiple glycine chelate thing monomer dissolve, dry, granulate, mix again, compare with conventional method, the above-mentioned preparation method of the present invention is directly with multiple inorganic microelement compound and glycine hybrid reaction, reach the again flow process of dissolving without drying, convection drying is granulated, this has not only saved production stage and process costs greatly, and so that the mixing of various compounds is more even.
Among the preparation method of above-mentioned economizing type trace element superpacket, described inorganic microelement compound preferably comprises Inorganic Copper, inorganic iron, inorganic zinc and inorganic manganese.Described Inorganic Copper preferably comprises one or more in copper chloride, copper sulphate, cupric oxide, Kocide SD, basic copper chloride, basic copper sulfate, the basic copper carbonate; Described inorganic iron preferably comprises one or more in frerrous chloride, ferrous sulfate, the ferrous carbonate; Described inorganic zinc preferably comprises one or more in zinc chloride, zinc sulfate, zinc hydroxide, zinc oxide, basic zinc sulfate, basic zinc carbonate, the basic zinc chloride; Described inorganic manganese preferably comprises one or more in manganous chloride, manganese sulfate, manganous hydroxide, manganous oxide, the alkali formula manganese sulfate.(inorganic compound of trace element includes its hydrate forms among the present invention, comprises that such as copper sulphate Salzburg vitriol etc. contains crystallization water form; Ferrous sulfate comprises that Feromax etc. contains crystallization water form, and following inorganic cobalt, inorganic nickel, inorganic Ge equally also are).
Among the preparation method of above-mentioned economizing type trace element superpacket, described inorganic microelement compound can also comprise one or more in inorganic cobalt, inorganic nickel, the inorganic Ge.Described inorganic cobalt preferably comprises one or more in cobalt oxide, cobalt hydroxide, cobalt chloride, cobaltous sulfate, cobalt carbonate, the basic cobaltous carbonate; Described inorganic nickel preferably comprises one or more in nickel oxide, nickel hydroxide, nickel chloride, nickelous sulfate, nickelous carbonate, the basic nickel carbonate; Described inorganic Ge preferably comprises one or more in germanium oxide, germanous chloride, calcium germinate, germanic acid copper, sodium metagermanate, two sodium germanates, four sodium germanates.
Above-mentioned preparation method can specifically adopt again any one in following three kinds of operation schemes.
Scheme 1: prepare a reactor, in the described glycine for preparing and described inorganic microelement compound together water-soluble rear adding reactor, regulate pH value to 3～10 with alkaline solution; Then open the exhaust outlet of reactor, the charge door of off-response still, the air inlet pipe of past reactor is filled with nitrogen until near the burning fire bavin of described exhaust outlet extinguishes, and closes described air inlet pipe and exhaust outlet; Be warming up to 30 ℃～100 ℃, abundant stirring reaction 0.5h～3h, blowing after reaction finishes, the mixture that adds again selenite, micro-basic salt and micro-sulfate in the product, the mixture (optionally adding glycine chromium this moment) that perhaps adds selenite, micro-basic salt, micro-sulfate and carrier, make homodisperse suspension, at last again in the vacuum cooled spray dryer drying and granulating obtain economizing type trace element superpacket finished product.
Method 2: prepare a reactor, in the water-soluble rear adding reactor of the described inorganic microelement compound for preparing, open the exhaust outlet of reactor, the charge door of off-response still, air inlet pipe toward reactor is filled with nitrogen until near the burning fire bavin of exhaust outlet extinguishes, and closes described air inlet pipe and exhaust outlet; Be warming up to 30 ℃～100 ℃, open described exhaust outlet, charge door and air inlet pipe, in the situation of inflated with nitrogen, in charge door, add the described glycine for preparing, regulate pH value to 3～10 with alkaline solution, close charge door, continue inflated with nitrogen until near the burning fire bavin of exhaust outlet extinguishes, close air inlet pipe and exhaust outlet; Abundant stirring reaction 0.5h～3h, blowing after reaction finishes, the mixture that adds again selenite, micro-basic salt and micro-sulfate in the product, the mixture (optionally adding glycine chromium this moment) that perhaps adds selenite, micro-basic salt, micro-sulfate and carrier, make homodisperse suspension, at last again in the vacuum cooled spray dryer drying and granulating obtain economizing type trace element superpacket finished product.
Method 3: prepare a reactor, in the water-soluble rear adding reactor of the described glycine for preparing, be warming up to 30 ℃～100 ℃, open the exhaust outlet of reactor, in the charge door of reactor, add the described inorganic microelement compound (optionally adding glycine chromium this moment) for preparing, regulate pH value to 3～10 with alkaline solution, close charge door, inflated with nitrogen in the air inlet pipe of reactor until near the exhaust outlet burning fire bavin extinguish, close air inlet pipe and exhaust outlet; Abundant stirring reaction 0.5h～3h, blowing after reaction finishes, the mixture that adds again selenite, micro-basic salt and micro-sulfate in the product, the mixture (optionally adding glycine chromium this moment) that perhaps adds selenite, micro-basic salt, micro-sulfate and carrier, make homodisperse suspension, at last again in the vacuum cooled spray dryer drying and granulating obtain economizing type trace element superpacket finished product.
In above-mentioned each scheme, described inorganic microelement compound is selected raw material, and its raw material proportioning satisfies that the quality of each element gets final product than scope in the technique scheme.Stirring reaction carries out in sealed reactor; its pressure-bearing scope is 1～5 atmospheric pressure; in the process of many ore deposits of synthetic glycine, be filled with the inert gas shieldings such as nitrogen; this has been avoided airborne oxygen to the oxidation of ferrous iron, bivalent manganese, divalence cobalt and nickelous; the defective that reduces or avoided animal can not absorb other valence state trace element; even the harm (absorb ferrous iron such as animal capable, but can not absorb ferric iron) of having avoided other valence state trace element to cause animal body.
In above-mentioned each scheme, the Drying Technology Parameter of vacuum cooled spray dryer of the present invention is: the material fine powder is 2%～25% (W/V) in the suspension, the pre-freeze material is to-5 ℃～-40 ℃ fast, dry vacuum is 0.01MPa～0.10MPa, temperature of heating plate is controlled at 10 ℃～50 ℃, condenser temperature is-10 ℃～-50 ℃, and flow-control is at 175ml/min～250ml/min, and the atomizer rotating speed is at 12000r/min～50000r/min.Compare with the vacuum cooled spray drying technology of existing high temperature drying granulation technique and pharmaceuticals industry, vacuum cooled spray-drying process technology of the present invention is take water as solvent, utilize innovatively carrier (if you would take off stone) in the animal stomach, to have the characteristics of adsorption and desorption, with carrier as sustained release agent and adsorbent, its vacuum cooled spray drying technology that is different from pharmaceuticals industry will be dissolved in absolute ethyl alcohol with the material of granulating, in Eudragit E 100 organic solvents such as grade, also need not with L-HPC, ethyl cellulose, the polyacrylic resin class, poly-hydroxyalkyl vinyl class is as sustained release agent, compare with the vacuum cooled spray drying technology of existing high temperature drying granulation technique and pharmaceuticals industry, the present invention not only raw material is easy to get more, cheaper, and safer environmental protection.
As a total technical conceive, the present invention also provides the application of a kind of above-mentioned economizing type trace element superpacket in animal feed additive.During this is used, described animal feed additive be specially adapted to pig with animal feed additive, fowl with animal feed additive, ruminant with animal feed additive, aquatic livestock with animal feed additive, special economic animal with animal feed additive or pet animal feed additive, the addition of described economizing type trace element superpacket when being used as animal feed additive is to add 0.5Kg～10Kg in the animal feed per ton.Preferred, the addition of described economizing type trace element superpacket as animal feed additive the time satisfies the content of trace element in the animal feed daily ration in following scope: copper 0.1～200ppm, iron 10～1250ppm, zinc 3～250ppm, manganese 2～150ppm, chromium 0～0.2ppm, cobalt 0～2ppm, nickel 0～10ppm, germanium 0～10ppm, selenium 0.01～0.5ppm.
Compared with prior art, the invention has the advantages that: economizing type of the present invention trace element superpacket product fully takes into account different to its demand of the complexity of different trace elements and glycine reactant and animal, by the further investigation to synthetic reaction principle theory, repeatedly sum up the test experience, polygamy side's new and effective economizing type trace element superpacket of finally accurately having arranged in pairs or groups and being suitable for variety classes and age level Animal needs; Composition and engineering of the present invention not only makes glycine and copper, iron, zinc, manganese and other trace element react more abundant, and owing to be added with the micro-basic salt with special physiological function, this is so that the collocation between the various trace element is more reasonable, micro-element nutrition value and antibacterial antidiarrheal convergence effect have been taken into account, be more conducive to absorption and the utilization of animal, make its quick healthy growth breeding.Simultaneously, economizing type trace element superpacket of the present invention can reduce micro-oxidation and destruction to vitamin and other nutriment in the feed storage process, reduce trace element mutual antagonism in vivo, other ANFs (such as phytic acid) is guaranteed the stable, high-quality, efficient of feed to its hurtful risk in the reduction feed.
The preparation method of economizing type trace element superpacket of the present invention has not only simplified production technology, save cost, and reduced the dust in the feedstuff additive premix compound production process, reduced the product loss, optimize production environment, be conducive to safeguard Manufacturing Worker's health; Preparation technology of the present invention also helps the mixture homogeneity that improves in the animal feed process, make copper, iron, zinc, manganese and other trace element mixture can prevent oxidized, mixture homogeneity is high, in the same size, not stratified, without moisture absorption caking, no dust pollution.
When economizing type trace element superpacket of the present invention is used in animal feed as additive, not only can effectively prevent the generation of copper, iron, zinc, manganese and other trace element deficiency, and can in alimentary canal, slowly discharge drug effect and absorption poisonous and harmful microorganism, can obviously improve the utilization rate of trace element, greatly reduce copper in the animal excrements, iron, zinc, manganese and other micro-discharge capacity, effectively reduce the generation to diseases such as the pollution of environment and diarrhoea; Have also that low, the short long-acting fruit of addition is obvious, efficiency of feed utilization is high, the animal side reaction is few, can add for a long time use and safety without advantages such as the resistances to the action of a drug.Particularly for different types of animal, according to its place of production, daily ration and the growth condition of production, reasonably combined, accurate proportioning different types of economizing type trace element superpacket, to satisfy the various demands in the daily growth productive life of animal.
The specific embodiment
Below in conjunction with embodiment the present invention is described further, but does not limit protection scope of the present invention because of following specific embodiment.
Embodiment 1: fowl economizing type trace element superpacket and preparation method thereof.
A kind of economizing type trace element superpacket of the present invention, this economizing type trace element superpacket can be used as laying hen economizing type trace element superpacket, this economizing type trace element superpacket is mainly by the many ore deposits of compound glycine, sodium selenite, the trace element basic salt, trace element sulfate and carrier form, sodium selenite, the many ore deposits of compound glycine, the mass ratio of trace element basic salt and micro-sulfate is 0.008: 15.8: 0.2: 1, the many ore deposits of compound glycine comprise cupric glycinate, ferrous bisglycinate chelate, glycine zine, Mn-Gly, glycine chromium, cobalt glycinate and nickel glycinate, the trace element basic salt is basic copper carbonate, basic nickel carbonate and basic zinc sulfate, trace element sulfate is copper sulphate, zinc sulfate and manganese sulfate, carrier are talcum powder, montmorillonite and medical stone.The mass ratio of copper, iron, zinc, manganese, cobalt, selenium, nickel, chromium is 3.9: 80: 54 in this economizing type trace element superpacket: 73: 0.25: 0.2: 0.2: 0.2.
The preparation method of the economizing type trace element superpacket of present embodiment may further comprise the steps: prepare a reactor, after 68.5g two hydration dichloride copper, 2898g Iron dichloride tetrahydrate, 572g zinc oxide, 2204g four hydration manganous chloride, 11.4g six hydration cobaltous sulfates, 6.9g six hydration nickel sulfate be dissolved in 50Kg water, open the exhaust outlet of reactor, the charge door of off-response still, air inlet pipe toward reactor is filled with nitrogen until near the burning fire bavin of exhaust outlet extinguishes, and closes air inlet pipe and exhaust outlet; Then be warming up to 82 ℃, open exhaust outlet, charge door and air inlet pipe, in the situation of inflated with nitrogen, in charge door, add the 2880g glycine, regulate after pH value is 6.2 with (1+1) ammonia spirit, close charge door, continue inflated with nitrogen until near the burning fire bavin of exhaust outlet extinguishes, close air inlet pipe and exhaust outlet, fully stirring reaction 1.2h.Blowing after reaction finishes, after adding 0.5Kg talcum powder, 1.0Kg montmorillonite, 4.4g sodium selenite, 21.3g basic copper carbonate, 8.0g Salzburg vitriol, 90.0g basic zinc sulfate, 112.5g Zinc sulfate monohydrate, 407.6g manganese sulfate monohydrate, 1.1g basic nickel carbonate, 17.2g glycine chromium and 1.2Kg medical stone, make homodisperse suspension, cross 60 mesh sieves by drying and granulating in the vacuum cooled spray dryer, namely obtain the laying hen economizing type trace element superpacket of present embodiment.The content (take element) of each composition is copper 0.39%, iron 8.0%, zinc 5.4% in the economizing type trace element superpacket, manganese 7.3%, chromium 0.02%, selenium 0.02%, cobalt 0.025%, nickel 0.02%, wherein amino acid content (take glycine) is 28.2%.The pressure-bearing scope of the sealed reactor that the present embodiment stirring reaction is used is 1～5 atmospheric pressure.The Drying Technology Parameter of vacuum cooled spray dryer is: the pre-freeze material is to-15 ℃ fast, and dry vacuum is 0.02MPa, and temperature of heating plate is controlled at 40 ℃, and condenser temperature is-20 ℃, and flow-control is at 180ml/min, and the atomizer rotating speed is at 45000r/min.
Embodiment 2: pig economizing type trace element superpacket and preparation method thereof.
A kind of economizing type trace element superpacket of the present invention, this economizing type trace element superpacket can be used as pig economizing type trace element superpacket, this economizing type trace element superpacket is mainly by the many ore deposits of compound glycine, sodium selenite, the trace element basic salt, trace element sulfate and carrier form, sodium selenite, the many ore deposits of compound glycine, the mass ratio of trace element basic salt and micro-sulfate is 0.02: 25: 1.2: 1, the many ore deposits of compound glycine comprise cupric glycinate, ferrous bisglycinate chelate, glycine zine, Mn-Gly, cobalt glycinate, glycine chromium and nickel glycinate, the trace element basic salt is basic copper chloride and basic zinc sulfate, trace element sulfate is copper sulphate, zinc sulfate and manganese sulfate, carrier are talcum powder, montmorillonite and feldspar powder.Copper, iron, zinc, manganese, cobalt, selenium, nickel, chromium mass ratio are 5.4: 111.7: 60.4 in the economizing type trace element superpacket: 27: 0.2: 0.3: 0.2: 0.1.
The preparation method of the economizing type trace element superpacket of present embodiment may further comprise the steps: prepare a reactor, after the 2483g glycine is dissolved in 50Kg water, be warming up to 95 ℃, open reactor exhaust outlet, reactor charge door in add the 180.5g Salzburg vitriol, the 3460g Feromax, 510g zinc oxide, the 627g Manganous sulfate monohydrate, 11.4g six hydration nickel sulfate and 9.7g six hydration cobaltous sulfates, regulating pH value with the sodium hydroxide solution of 0.2mol/L is 6.5, close charge door, in the air inlet pipe of reactor, be filled with nitrogen until near the burning fire bavin of exhaust outlet extinguishes, close air inlet pipe and exhaust outlet; Abundant stirring reaction 0.75h.Blowing after reaction finishes, after adding 0.5Kg talcum powder, 1.0Kg montmorillonite, 6.7g sodium selenite, 7.7g glycine chromium, 8.6g basic copper chloride, 16.0g cupric sulfate pentahydrate, 323.5g basic zinc sulfate, 67.5g monohydrate zinc sulphate, 219.5g manganese sulfate monohydrate and 1.2Kg feldspar powder, make homodisperse suspension, cross 40 mesh sieves by drying and granulating in the vacuum cooled spray dryer, the fattening pig that obtains present embodiment is with new and effective economizing type trace element superpacket.The content (take element) of each composition is copper 0.54%, iron 11.17%, zinc 6.04% in the economizing type trace element superpacket, manganese 2.70%, selenium 0.03%, cobalt 0.02%, nickel 0.02%, chromium 0.01%, wherein amino acid content (take glycine) is 24.3%.The pressure-bearing scope of the sealed reactor that the present embodiment stirring reaction is used is 1～5 atmospheric pressure.The Drying Technology Parameter of vacuum cooled spray dryer is: the pre-freeze material is to-18 ℃ fast, and dry vacuum is 0.05MPa, and temperature of heating plate is controlled at 35 ℃, and condenser temperature is-20 ℃, and flow-control is at 180ml/min, and the atomizer rotating speed is at 43000r/min.
Embodiment 3: ruminant economizing type trace element superpacket and preparation method thereof.
A kind of economizing type trace element superpacket of the present invention, this economizing type trace element superpacket is beef cattle economizing type trace element superpacket, this economizing type trace element superpacket is mainly by the many ore deposits of compound glycine, sodium selenite, the trace element basic salt, trace element sulfate and carrier form, sodium selenite, the many ore deposits of compound glycine, the mass ratio of trace element basic salt and micro-sulfate is 0.04: 20.2: 0.7: 1, the many ore deposits of compound glycine comprise cupric glycinate, ferrous bisglycinate chelate, glycine zine, Mn-Gly, cobalt glycinate, glycine chromium and nickel glycinate, the trace element basic salt is basic copper chloride and basic zinc chloride, trace element sulfate is copper sulphate, zinc sulfate and manganese sulfate, carrier are talcum powder, montmorillonite and medical stone.The mass ratio of copper, iron, zinc, manganese, cobalt, selenium, nickel, chromium is 20: 310: 185 in this economizing type trace element superpacket: 125: 2.5: 3: 1.5: 2.
The preparation method of the economizing type trace element superpacket of present embodiment may further comprise the steps: prepare a reactor, with the 40.1g Salzburg vitriol, the 960g Feromax, the 283g Zinc sulfate monohydrate, the 314g Manganous sulfate monohydrate, 11.4g six hydration cobaltous sulfates, 6.9g six hydration nickel sulfate and 717g glycine are dissolved in the 50Kg water together, regulating the pH value with the sodium hydroxide solution of 0.1mol/L is 6.8, open the exhaust outlet of reactor, the charge door of off-response still, air inlet pipe toward reactor is filled with nitrogen until near the burning fire bavin of exhaust outlet extinguishes, and closes air inlet pipe and exhaust outlet.Be heated to 70 ℃, fully stirring reaction 1h.Blowing after reaction finishes, after adding 0.3Kg talcum powder, 0.6Kg montmorillonite, 6.7g sodium selenite, 17.9g glycine chromium, 13.7g basic copper chloride, 100g basic zinc chloride, 8.0g Salzburg vitriol, 70g Zinc sulfate monohydrate, 78.5g Manganous sulfate monohydrate and 6.1Kg medical stone, make homodisperse suspension, cross beef cattle that 80 mesh sieves are present embodiment with new and effective economizing type trace element superpacket by drying and granulating in the vacuum cooled spray dryer.The content (take element) of each composition is copper 0.20%, iron 3.10%, zinc 1.85% in the economizing type trace element superpacket, manganese 1.25%, selenium 0.03%, cobalt 0.025%, nickel 0.015%, chromium 0.02%, wherein amino acid content (take glycine) is 7.0%.The pressure-bearing scope of the sealed reactor that the present embodiment stirring reaction is used is 1～5 atmospheric pressure.The Drying Technology Parameter of vacuum cooled spray dryer is: the pre-freeze material is to-10 ℃ fast, and dry vacuum is 0.03MPa, and temperature of heating plate is controlled at 34 ℃, and condenser temperature is-20 ℃, and flow-control is at 235ml/min, and the atomizer rotating speed is 41000r/min.
Embodiment 4: laying hen economizing type trace element superpacket application as feed addictive in egg feedstuff.
The feeding experiment that economizing type among the embodiment 1 trace element superpacket is used for laying hen.Select physically fit, body weight is close, egg laying performance is similar 28 age in week the commercial generation layer of green-shell egg be divided at random 3 groups, every group of 20 plumages, experimental period are 28d.Duration of test free choice feeding, drinking-water are observed chicken group health status every day, and egg number, egg size and feed consumption respectively organized in record.Randomly draw every group of 6 pieces of eggs of the 14th day, the 28th day, measure nutritional labeling.Loss on drying is measured moisture; Copper sulphate-micro-nitriding is measured protein; The Soxhlet extraction process is measured fat.
The duration of test control group fed place of production is the basal diet of the Northeast.Basal diet is comprised of corn, soya-bean cake, calcium carbonate, calcium bicarbonate, oyster shell whiting, egg hydracid, multidimensional, sodium chloride, trace element etc.Contain crude protein (CP) 16.96% in the basal diet, ME 11.38 kJ/kg, Ca 3.6%.P 0.65%, I 0.5mg/kg, Se 0.01mg/kg, Co 0.1mg/kg.Wherein, control group is only fed basal diet, tests the economizing type trace element superpacket 0.5Kg that adds embodiment 1 in one group of basal diet per ton, the economizing type trace element superpacket 1.0Kg that tests interpolation embodiment 1 in two groups of basal diets per ton.Result of the test sees the following form shown in 1.
Table 1: laying hen uses economizing type trace element superpacket on the impact of performance in layers
Notes: in the upper table 1, colleague's shoulder marking-up parent phase expression difference together is remarkable (p＞0.05) not; The not identical expression variant (p＜0.05) of colleague shoulder marking-up mother.
As can be seen from Table 1, in the situation that feed intake changes without conspicuousness (p＞0.05), control group and test group egg size be substantially without conspicuousness variation (p＞0.05), significant difference (p＜0.05) all arranged at laying rate and egg material on than index.This result of the test shows: laying rate and the egg material ratio that can significantly improve laying hen in laying hens essential ration behind the interpolation economizing type trace element of the present invention superpacket.
Embodiment 5: piglet with economizing type trace element superpacket and in weanling pig as the application of feed addictive.
A kind of economizing type trace element superpacket of the present invention, this economizing type trace element superpacket is pig economizing type trace element superpacket, this economizing type trace element superpacket is mainly by the many ore deposits of compound glycine, calcium selenite, the trace element basic salt, trace element sulfate and carrier form, calcium selenite, the many ore deposits of compound glycine, the mass ratio of trace element basic salt and micro-sulfate is 0.8: 15.8: 0.2: 1, the many ore deposits of compound glycine comprise cupric glycinate, ferrous bisglycinate chelate, glycine zine, Mn-Gly, glycine chromium, cobalt glycinate, and nickel glycinate, the trace element basic salt is basic zinc chloride, trace element sulfate is monohydrate zinc sulphate, and carrier is white carbon, talcum powder and montmorillonite.The mass ratio of copper, iron, zinc, manganese, chromium, cobalt, selenium, nickel is 7.4: 85: 70 in this economizing type trace element superpacket: 20: 0.15: 0.15: (mass fraction of main nutrient composition and trace element was in this economizing type trace element superpacket: copper 0.74% in 0.2: 0.15, iron 8.50%, zinc 7.00%, manganese 2.00%, chromium 0.015%, selenium 0.02%, cobalt 0.015%, nickel 0.015%, glycine 19.80%).The preparation technology of the economizing type of present embodiment trace element superpacket is except material composition and prescription, and all the other operating procedures and technological parameter are identical with preparation technology among the embodiment 2.
The feeding experiment that the economizing type trace element superpacket of present embodiment is used for weanling pig.Select 108 of the healthy anosis weanling pigs that kind consistent (Du * long * large), birth age in days approach, be divided at random control group and two test group, every group of 6 repetitions, each repeats 6 pigs, as feed addictive, control group is the pig basal diet to test group with the micro-superpacket of the economizing type of present embodiment.Wherein, test one group of pig per ton economizing type trace element superpacket 0.5Kg that adds present embodiment in the basal diet, test two groups of pigs per ton with adding economizing type trace element superpacket 1.0Kg in the basal diet, feeding time was 2 weeks, and feeding effect is as shown in table 2 below.
Table 2: piglet uses economizing type trace element superpacket on the impact of Growth Performance of Weaning Piglets
Notes: in the upper table 2, same column shoulder marking-up parent phase is with representing difference not remarkable (p＞0.05); Same column shoulder marking-up mother is identical table differential different significantly (p＜0.05) not, and is lower same.
The test data of upper table 2 shows: speed of growth significant difference between test group and control group (p＜0.05); Although each test group on the feed intake index with control group difference not significantly (p＞0.05), but significant difference (p＜0.05) on weightening finish and feedstuff-meat ratio index, raising along with the economizing type of present embodiment trace element superpacket addition, its weightening finish is improved trend, feedstuff-meat ratio has downward trend, and showing economizing type trace element superpacket of the present invention has good growth result to weanling pig.
Embodiment 6: pig with economizing type trace element superpacket and in the growth pig as the application of feed addictive.
A kind of economizing type trace element superpacket of the present invention, this economizing type trace element superpacket is pig economizing type trace element superpacket, this economizing type trace element superpacket is mainly by the many ore deposits of compound glycine, sodium selenite, the trace element basic salt, trace element sulfate forms, sodium selenite, the many ore deposits of compound glycine, the mass ratio of trace element basic salt and micro-sulfate 0.02: 16.2: 0.5: 1, the many ore deposits of compound glycine comprise cupric glycinate, ferrous bisglycinate chelate, glycine zine, Mn-Gly, glycine chromium, cobalt glycinate, the trace element basic salt is basic copper carbonate, basic copper sulfate, basic copper chloride, basic nickel carbonate, basic zinc sulfate, trace element sulfate is monohydrate zinc sulphate and manganese sulfate monohydrate, carrier-free.The mass ratio of copper, iron, zinc, manganese, chromium, cobalt, selenium is 3: 15: 10 in this economizing type trace element superpacket: 4: 0.03: 0.025: 0.02 (mass fraction of main nutrient composition and trace element is in this economizing type trace element superpacket: copper 3.00%, iron 15.00%, zinc 10.00%, manganese 4.00%, chromium 0.03%, selenium 0.02%, cobalt 0.025%, glycine 35.20%).The preparation technology of the economizing type of present embodiment trace element superpacket is except material composition and prescription, and all the other operating procedures and technological parameter are identical with preparation technology among the embodiment 2.
The feeding experiment that the economizing type trace element superpacket of present embodiment is used for the growth pig.Select 90 growth pigs that age in days is close, weight differential is little (ternary hybrid pig) as test pig, according to body weight, principle that sex ratio is identical, be divided at random one, two group of control group and test, every group of 3 repetitions, each repeats 10 head growth pigs, and the nursing time is 28 days.Wherein control group is basal diet, tests the economizing type trace element superpacket 1.0Kg that adds present embodiment in one group of basal diet per ton, the economizing type trace element superpacket 2.0Kg that tests interpolation present embodiment in two groups of basal diets per ton.Result of the test is shown in Table 3.
Table 3: pig uses economizing type trace element superpacket on the impact of growth pig growth performance
| Group | Initial body weight/kg | Average daily gain/kg | Average every feed consumption/kg | Feedstuff-meat ratio |
| Control group | 50.31±0.98 a | 0.74±0.12 a | 45.07±1.59 a | 2.17±0.15 a |
| Test one group | 50.27±0.67 a | 0.83±0.08 b | 46.35±1.28 b | 2.01±0.11 b |
| Test two groups | 50.15±0.48 a | 0.85±0.04 b | 46.84±1.27 b | 1.97±0.16 b |
Can be found out by upper table 3, reach conspicuousness poor (p＜0.05) in average daily gain, the feedstuff-meat ratio index of duration of test test group and control group, variant between test group.The result of above-mentioned table 3 shows: the speed of growth significant difference (p＜0.05) of growth pig between test group and control group; Significant difference on feed intake, weightening finish and the feedstuff-meat ratio index (p＜0.05), raising along with present embodiment economizing type trace element superpacket addition, its weightening finish is improved trend, feedstuff-meat ratio has downward trend, and showing economizing type trace element superpacket of the present invention has good growth result to the growth pig.
Embodiment 7: fattening pig economizing type trace element superpacket application as additive in the fattening pig feed.
The feeding experiment that economizing type among the embodiment 2 trace element superpacket is used for fattening pig.Select 90 fattening pigs that age in days is close, weight differential is little (ternary hybrid pig) as test pig, according to body weight, principle that sex ratio is identical, be divided at random one, two group of control group and test, every group of 3 repetitions, each repeats 10 fattening pigs, and the nursing time is 35 days.Wherein, control group is basal diet, tests the efficient economizing trace element superpacket 1.5Kg that adds embodiment 2 in one group of basal diet per ton, the economizing type trace element superpacket 3.0Kg that tests interpolation embodiment 2 in two groups of basal diets per ton.Result of the test is as shown in table 4 below.
Table 4: pig uses economizing type trace element superpacket on the impact of Growth of Pigs performance
| Group | Initial body weight kg | Average daily gain kg | Average every feed consumption kg | Feedstuff-meat ratio |
| Control group | 82.31±1.24 a | 0.74±0.15 a | 70.42±2.49 a | 2.72±0.23 a |
| Test one group | 82.28±0.89 a | 0.79±0.09 b | 72.97±2.27 b | 2.65±0.17 b |
| Test two groups | 82.14±0.78 a | 0.84±0.07 b | 75.08±2.21 b | 2.54±0.15 b |
As can be seen from Table 4, reach significant difference (p＜0.05) in average daily gain, the feedstuff-meat ratio index of duration of test test group and control group, variant between test group.The result of upper table 4 shows: the speed of growth significant difference of fattening pig (p＜0.05) between test group and control group; Significant difference on feed intake, weightening finish and the feedstuff-meat ratio index (p＜0.05), raising along with economizing type trace element superpacket addition, its weightening finish is improved trend, feedstuff-meat ratio has downward trend, and this shows efficient economizing trace element superpacket of the present invention has good fattening effect to fattening pig.
Embodiment 8: the general economizing type of boar trace element superpacket and in sow feed as the application of feed addictive.
A kind of economizing type trace element superpacket of the present invention, this economizing type trace element superpacket is pig economizing type trace element superpacket, this economizing type trace element superpacket is mainly by the many ore deposits of compound glycine, calcium selenite, the trace element basic salt, trace element sulfate and carrier form, calcium selenite, the many ore deposits of compound glycine, the mass ratio of trace element basic salt and micro-sulfate is 0.9: 48.7: 1.2: 1, the many ore deposits of compound glycine comprise cupric glycinate, ferrous bisglycinate chelate, glycine zine, Mn-Gly, glycine chromium, cobalt glycinate, the trace element basic salt is basic copper chloride and basic zinc chloride, trace element sulfate is six hydration nickel sulfate, and carrier is montmorillonite, feldspar powder and white carbon.The mass ratio of copper, iron, zinc, manganese, chromium, cobalt, selenium is 1.9: 10.4: 5.7 in this economizing type trace element superpacket: 2: 0.03: 0.05: 0.02 (mass fraction of main nutrient composition and trace element is in this economizing type trace element superpacket: copper 1.90%, iron 10.40%, zinc 5.70%, manganese 2.00%, chromium 0.03%, selenium 0.02%, cobalt 0.05%, glycine 46.1%).The preparation technology of the economizing type of present embodiment trace element superpacket is except material composition and prescription, and all the other operating procedures and technological parameter are identical with preparation technology among the embodiment 2.
The feeding experiment that the economizing type trace element superpacket of present embodiment is used for brood sow.Select the Du Luoke sow of same parity, be divided into three groups (one, two group of control group and test), every group 20, breed with 2～3 Duroc boars for every group, requirement is finished breeding within an oestrus, wherein control group is basal diet, tests the economizing type trace element superpacket 0.5Kg that adds present embodiment in one group of basal diet per ton, tests the economizing type trace element superpacket 1.0Kg that adds present embodiment in two groups of basal diets per ton.Result of the test is as shown in table 5.
Table 5: the general economizing type trace element of pig superpacket is on the impact of brood sow production performance
As can be seen from Table 5, for the nascent young number of work, control group and test group reach significant difference (p＜0.05), but on the not impact of nascent litter weight; Along with the variation of feeding time, the young number of the work of its 21 age in days also changes thereupon, and litter weight begins to show larger difference, and survival rate has the difference (p＜0.05) of conspicuousness; During 42 age in days, the performance of the young number of living is similar to 21 ages in days, and incubation rate also reaches significant difference (p＜0.05).Above application result shows: the test group of adding the general economizing type trace element of the boar superpacket of present embodiment, the young number of the work of brood sow, the survival rate in later stage, incubation rate all have the raising of conspicuousness than control group, and litter weight also is greatly improved than control group, and this shows economizing type of the present invention trace element superpacket the reproductive performance of brood sow is improved a lot.
Embodiment 9: ox economizing type trace element superpacket application as feed addictive in the calf feed.
The feeding experiment that economizing type in above-described embodiment 3 trace element superpacket is used for calf.21 calves (80～90 age in days) of selecting the hybridization of same black-and-white flower breeding oxen and primiparity Qin Chuan cow to give birth to are the test ox, are divided at random 3 groups, 7 every group.Wherein control group is basal diet, tests the economizing type trace element superpacket 0.5Kg that adds embodiment 3 in one group of basal diet per ton, the economizing type trace element superpacket 1.0Kg that tests interpolation embodiment 3 in two groups of basal diets per ton.Experimental period, is 37d altogether, and wherein preliminary trial period 7d is just trying phase 30d.Result of the test sees the following form 6.
Table 6: ox uses economizing type trace element superpacket on the impact of calf growth performance
| Group | Initial body weight/kg | End weight/kg | Average daily gain/kg |
| Control group | 53.4±1.48 a | 71.3±1.61 a | 0.60±0.08 a |
| Test one group | 52.6±1.36 a | 74.9±1.84 b | 0.74±0.09 b |
| Test two groups | 53.0±1.16 a | 79.8±0.84 c | 0.89±0.07 c |
As can be seen from Table 6, under the condition that initial body weight is more or less the same, significant difference (p＜0.05) is arranged in the average daily gain of test group and control group, and significant difference (p＜0.05) between test group.The result of upper table 6 shows: the speed of growth significant difference of calf (p＜0.05) between test group and control group; And along with the raising of economizing type trace element superpacket addition of the present invention, its daily gain is improved trend, and this shows economizing type trace element superpacket of the present invention has good growth-promoting effect to calf.
Embodiment 10: fresh-water fishes with economizing type trace element superpacket and in Russian carp feed as the application of feed addictive.
A kind of economizing type trace element superpacket of the present invention, this economizing type trace element superpacket is pig economizing type trace element superpacket, this economizing type trace element superpacket is mainly by the many ore deposits of compound glycine, sodium selenite, the trace element basic salt, trace element sulfate and carrier form, sodium selenite, the many ore deposits of compound glycine, the mass ratio of trace element basic salt and micro-sulfate is 0.02: 3.5: 9.9: 1, the many ore deposits of compound glycine comprise cupric glycinate, ferrous bisglycinate chelate, glycine zine, Mn-Gly, glycine chromium and cobalt glycinate, the trace element basic salt is basic nickel carbonate, basic copper sulfate and basic zinc chloride, trace element sulfate is Cobalt monosulfate heptahydrate and anhydrous manganous sulfate, and carrier is talcum powder and medical stone.The mass ratio of copper, iron, zinc, manganese, chromium, cobalt, selenium is 8: 100: 80 in this economizing type trace element superpacket: 40: 0.4: 0.4: 0.8 (mass fraction of main nutrient composition and trace element is in this economizing type trace element superpacket: copper 0.80%, iron 10.00%, zinc 8.00%, manganese 4.00%, chromium 0.04%, selenium 0.08%, cobalt 0.04%, glycine 7.2%).The preparation technology of the economizing type of present embodiment trace element superpacket is except material composition and prescription, and all the other operating procedures and technological parameter are identical with preparation technology among the embodiment 2.
The feeding experiment that the economizing type trace element superpacket of present embodiment is used for Russian carp.Selecting healthy, even, initial body weight is Russian carp 1500 tails of (114.4 ± 2.1) g, is equally divided into 5 processing, and each processes 3 repetitions, and each repeats 100 tails, and each pond is 1 and repeats cement pit specification 6m * 9m.Fingerling is bought the same day back and is divided into groups immediately, after the grouping with the anti-bacteria and virus sterilization of splashing; Dead fish is selected the fish substitute for subsequent use that specification approaches in the 1st week, progressively finishes testing material to the replacement of former feed in the 3d after the grouping; Duration of test is thrown something and fed 4 times under normal circumstances every day, starts aerator according to weather condition in good time; The every two weeks of duration of test changes weekly water 1/3 with chlorinated product sterilization 1 time, and dissolved oxygen keeps more than the 6mg/L, experimental period 70d.Wherein, control group is basal diet, test the fresh-water fishes of adding present embodiment in one group of basal diet per ton economizing type trace element superpacket 250g, test the fresh-water fishes of adding present embodiment in two groups of basal diets per ton economizing type trace element superpacket 500g.Wherein, crude protein 35.00% in the basal diet, crude fat 5.40%, available phosphorus 0.60%.Result of the test sees Table 7.
Table 7: fresh-water fishes use economizing type trace element superpacket on the impact of Russian carp growth performance
| Project | Control group | Test one group | Test two groups |
| Initial weight/g | 112.9±2.2 a | 115.4±1.0 a | 114.4±2.9 a |
| End weight/g | 516.0±4.5 a | 528.3±9.1a b | 538.0±14.3a b |
| Weightening finish/g | 403.1±3.1 a | 412.9±9.1 ab | 413.6±11.4 ab |
| The relative weight gain rate/% | 263.6±3.8 a | 265.7±6.1 b | 267.8±2.6 b |
| Take the photograph bait amount/g | 520.0±12.4 a | 520.2±9.9 a | 517.0±16.8 a |
| Feed coefficient | 1.29±0.02 ab | 1.26±0.02 b | 1.25±0.05 b |
| The death rate/% | 2.3 a | 1.7 b | 1.5 b |
As can be seen from Table 7: test group and control group do not have significant change taking the photograph the bait amount, but on weightening finish, the relative weight gain rate, feed coefficient and the death rate significant difference (p＜0.05) are arranged all, and variant between test group.The result of upper table 7 shows: the growth of carp and survival difference on effect remarkable (p＜0.05) between test group and control group; And the raising along with economizing type trace element superpacket addition of the present invention, the relative weight gain rate is improved trend, the death rate and feed coefficient all have a declining tendency, and this shows economizing type trace element superpacket of the present invention has good growth result to Russian carp.
Claims (8)
1. economizing type trace element superpacket that is used for animal feed additive, it is characterized in that: described economizing type trace element superpacket mainly is comprised of the many ore deposits of compound glycine, micro-basic salt, selenite and micro-sulfate, and the mass ratio of described selenite, the many ore deposits of compound glycine, micro-basic salt and micro-sulfate is (0.001～1): (0.01～50): (0.01～10): 1; The many ore deposits of described compound glycine comprise cupric glycinate, ferrous bisglycinate chelate, glycine zine and Mn-Gly, and described micro-basic salt comprises one or more in trace copper, zinc, manganese corresponding alkali formula chlorate, subcarbonate or the subsulfate; Described micro-sulfate comprises one or more in copper sulphate, ferrous sulfate, zinc sulfate, manganese sulfate, Ge(SO), cobaltous sulfate, the nickelous sulfate; The many ore deposits of described compound glycine also comprise one or more in glycine chromium, cobalt glycinate, nickel glycinate, the glycine germanium; Described micro-basic salt also comprises one or more in trace element cobalt, nickel, germanium corresponding alkali formula chlorate, subsulfate or the subcarbonate.
2. economizing type according to claim 1 trace element superpacket is characterized in that: described economizing type trace element superpacket is fowl with economizing type trace element superpacket, pig with economizing type trace element superpacket, ruminant with economizing type trace element superpacket, aquatic livestock with economizing type trace element superpacket, special economic animal with economizing type trace element superpacket or pet with economizing type trace element superpacket;
Described fowl is (0.1～35) with the mass ratio of copper, iron, zinc, manganese in the economizing type trace element superpacket: (15～750): (5～150): (10～150);
Described pig is (1～200) with the mass ratio of copper, iron, zinc, manganese in the economizing type trace element superpacket: (15～750): (10～200): (8～150);
Described ruminant is (0.1～35) with the mass ratio of copper, iron, zinc, manganese in the economizing type trace element superpacket: (10～750): (3～150): (10～150);
Described aquatic livestock is (0.1～25) with the mass ratio of copper, iron, zinc, manganese in the economizing type trace element superpacket: (20～750): (15～200): (2～100);
Described special economic animal is (3～200) with the mass ratio of copper, iron, zinc, manganese in the economizing type trace element superpacket: (30～1250): (20～250): (10～150);
Described pet is preferably (3～200) with the mass ratio of copper, iron, zinc, manganese in the economizing type trace element superpacket: (30～1250): (20～250): (10～150).
3. economizing type according to claim 1 and 2 trace element superpacket, it is characterized in that: described economizing type trace element superpacket is granular preparation, also include carrier in the described economizing type trace element superpacket, described carrier comprises one or more in medical stone, zeolite powder, feldspar powder, talcum powder, montmorillonite, the white carbon.
4. the preparation method of an economizing type as claimed in claim 3 trace element superpacket, may further comprise the steps: the raw material glycine and the inorganic microelement compound that prepare are added to the water by said ratio and order, after adjusting pH value is 3～10, be warming up to 30 ℃～100 ℃, abundant stirring reaction 0.5h～3h, pressure during reaction is 1～5 atmospheric pressure, blowing after reaction is finished, in product, add selenite again, the mixture of trace element basic salt and micro-sulfate, perhaps add selenite, the trace element basic salt, the mixture of trace element sulfate and carrier, make homodisperse suspension, obtain economizing type trace element superpacket finally by drying and granulating; Wherein, the ratio of micro-total mole number is (3.2～0.8) in the molal quantity of described glycine and the described inorganic microelement compound: 1.
5. preparation method according to claim 4, it is characterized in that: described inorganic microelement compound comprises Inorganic Copper, inorganic iron, inorganic zinc and inorganic manganese; Described Inorganic Copper comprises one or more in copper chloride, copper sulphate, cupric oxide, Kocide SD, basic copper chloride, basic copper sulfate, the basic copper carbonate; Described inorganic iron comprises one or more in frerrous chloride, ferrous sulfate, the ferrous carbonate; Described inorganic zinc comprises one or more in zinc chloride, zinc sulfate, zinc hydroxide, zinc oxide, basic zinc sulfate, basic zinc carbonate, the basic zinc chloride; Described inorganic manganese comprises one or more in manganous chloride, manganese sulfate, manganous hydroxide, manganous oxide, the alkali formula manganese sulfate.
6. according to claim 4 or 5 described preparation methods, it is characterized in that: described inorganic microelement compound also comprises one or more in inorganic cobalt, inorganic nickel, the inorganic Ge; Described inorganic cobalt comprises one or more in cobalt oxide, cobalt hydroxide, cobalt chloride, cobaltous sulfate, cobalt carbonate, the basic cobaltous carbonate; Described inorganic nickel comprises one or more in nickel oxide, nickel hydroxide, nickel chloride, nickelous sulfate, nickelous carbonate, the basic nickel carbonate; Described inorganic Ge comprises one or more in germanium oxide, germanous chloride, calcium germinate, germanic acid copper, sodium metagermanate, two sodium germanates, four sodium germanates.
7. one kind such as each described economizing type trace element superpacket application in animal feed additive in the claim 1～3, it is characterized in that, described animal feed additive comprise pig with animal feed additive, fowl with animal feed additive, ruminant with animal feed additive, aquatic livestock with animal feed additive, special economic animal with animal feed additive or pet animal feed additive; The addition of described economizing type trace element superpacket as animal feed additive the time is to add 0.5Kg～10Kg in the animal feed per ton.
8. application according to claim 7, it is characterized in that, the addition of described economizing type trace element superpacket as animal feed additive the time satisfies the content of trace element in the animal feed daily ration in following scope: copper 0.1～200 ppm, iron 10～1250 ppm, zinc 3～250 ppm, manganese 2～150 ppm, chromium 0～0.2 ppm, cobalt 0～2 ppm, nickel 0～10 ppm, germanium 0～10 ppm, selenium 0.01～0.5ppm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210016075 CN102524540B (en) | 2012-01-18 | 2012-01-18 | Saving trace element compound packet as well as preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210016075 CN102524540B (en) | 2012-01-18 | 2012-01-18 | Saving trace element compound packet as well as preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102524540A CN102524540A (en) | 2012-07-04 |
| CN102524540B true CN102524540B (en) | 2013-05-29 |
Family
ID=46333583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210016075 Active CN102524540B (en) | 2012-01-18 | 2012-01-18 | Saving trace element compound packet as well as preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102524540B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP1200394A2 (en) * | 2012-06-29 | 2014-02-28 | Bata Zrt Dr | Bactericidal effect of metal chelate |
| CN103005187B (en) * | 2012-12-07 | 2014-03-05 | 浙江群大饲料有限公司 | Composite trace element additive for three-yellow broiler |
| CN104222693A (en) * | 2014-10-11 | 2014-12-24 | 来光业 | Pig feed and producing method thereof |
| CN105600817B (en) * | 2016-01-22 | 2018-08-21 | 广州英赛特生物技术有限公司 | A kind of zinc sulfate calcium complexes and its application in preparing feed addictive |
| AU2018273033A1 (en) * | 2017-05-26 | 2019-12-19 | Nutreco Ip Assets B.V. | Pet food product comprising a basic metal salt |
| TWI742333B (en) * | 2018-03-06 | 2021-10-11 | 普惠德生技股份有限公司 | Use of ferrous amino acid chelate to treat infection by enteropathogen and to enhance growth performance |
| CN109043221A (en) * | 2018-09-25 | 2018-12-21 | 建德市维丰饲料有限公司 | A kind of preparation method of feed pre-mixing material for poultry and products thereof and application |
| CN111743915A (en) * | 2020-07-15 | 2020-10-09 | 河北真信粘土科技发展有限公司 | Traditional Chinese medicine formula for preventing and treating diarrhea and epidemic gastroenteritis and preparation method thereof |
| CN111978189B (en) * | 2020-08-25 | 2023-06-06 | 重庆森乐美生物科技有限公司 | Preparation method and production system of glycine complex manganese salt premix |
| CN115211497A (en) * | 2022-07-28 | 2022-10-21 | 广州市富泉生物科技有限公司 | Slow-release trace element premix feed and preparation method thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1022373C (en) * | 1989-10-11 | 1993-10-13 | 刘长久 | Animal nutrient solution |
| CN101002593A (en) * | 2006-01-18 | 2007-07-25 | 内蒙古草原兴发股份有限公司 | Feed for grown Caoyaun luniao chicken |
| CN100399934C (en) * | 2006-03-17 | 2008-07-09 | 中国科学院海洋研究所 | Nuisance free special microelement additive for bastard halibut and pleuronectid and its production process |
| CN101049128B (en) * | 2006-04-04 | 2011-02-09 | 上海光明荷斯坦牧业有限公司 | Composite prepaid feedstuff capable of raising breeding performance of milch cow |
| CN101120732B (en) * | 2007-09-07 | 2010-09-29 | 济南和美华饲料有限公司 | Feed for promoting nursery pig immunity |
| CN101120731B (en) * | 2007-09-07 | 2010-12-01 | 济南和美华饲料有限公司 | Feed for improving sow oestrum and increasing farrowing amount |
| CN101181013B (en) * | 2007-11-15 | 2010-07-28 | 广东粤海饲料集团有限公司 | Universal feedstuff additive for sea water fish |
| CN101584417B (en) * | 2009-06-24 | 2011-12-14 | 河南雄峰科技有限公司 | Porket premix compound and porket creep feed prepared by the premix compound |
| CN101744120B (en) * | 2009-12-25 | 2012-04-11 | 河北农业大学 | Trace element premix for piglets |
-
2012
- 2012-01-18 CN CN 201210016075 patent/CN102524540B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN102524540A (en) | 2012-07-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102524540B (en) | Saving trace element compound packet as well as preparation method and application thereof | |
| CN102550836B (en) | Animal nutrition additive trace element is combined bag and its preparation method and application | |
| CN102318785B (en) | Sow feed additive for improving birth weight and lactation quantity and production method for sow feed additive | |
| WO2022063295A1 (en) | Additive for increasing survival rate of aquaculture animals and application thereof | |
| CN106721516A (en) | A kind of aquatic products anti-stress feed and feed addictive | |
| CN101889634A (en) | Organic selenium-supplementing feed additive and preparation and using method thereof | |
| CN105614099A (en) | Functional clean daily ration for improving health of pregnant sows and improving reproductive performance of pregnant sows | |
| CN107573253B (en) | N, N-dimethyl glycine organic acid conjugate acid salt, composition and application thereof | |
| CN102578386B (en) | Compound many ore deposits of glycine and its preparation method and application | |
| CN110235997A (en) | A kind of mineral feed supplement and its preparation method and application containing nanometer selenium | |
| CN106243162A (en) | The preparation method of sucrose complex | |
| CN103960531A (en) | Breeding method for reducing emission of nitrogen and phosphorus heavy metals in excrements of conventional semi-free black pigs | |
| CN102422985B (en) | Iodine, selenium and cobalt composite package for animal feed and preparation method and application method thereof | |
| WO2010074602A1 (en) | Bioavailable form of microelement additives to feed mixtures for animals and birds | |
| CN102550830B (en) | Method for applying and preparing gamma-aminobutyric acid complex compound | |
| CN107319164A (en) | A kind of complex compound of secondary Complexing Iron and its production and use | |
| CN102007884A (en) | Method for producing eggs rich in multiple trace elements | |
| CN108552420A (en) | A kind of feed addictive and its application | |
| RU2530815C2 (en) | Feed additive for animals and birds | |
| CN107232414A (en) | The compound additive and preparation method of a kind of the feed for piglet | |
| CN103005165A (en) | Preparation method of lactobionic acid microelement complex and application of complex as animal feed additive | |
| CN105724779A (en) | Compound feeding composition and application of compound feeding composition in preparation of animal feed additive | |
| CN101597237B (en) | Iron (II)-threonine and preparation method and application thereof | |
| CN113170837A (en) | Copper aspartate complex and application thereof | |
| CN102524541B (en) | Preparation method of nickel methionine and application of nickel methionine in animal feed additives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: CHANGSHA XINGJIA BIO-ENGINEERING CO., LTD. Free format text: FORMER OWNER: CHANGSHA XINGJIA BIOTECHNOLOGY CO., LTD. Effective date: 20140425 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20140425 Address after: Kang Ning Lu Hunan province 410329 city Changsha Changsha national biological industry base 370 Patentee after: Changsha Xingjia Bio-engineering Co., Ltd. Address before: 410329 Liuyang biological medicine Park, Hunan, Changsha Patentee before: Changsha Xingjia Biological Technology Co., Ltd. |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Saving trace element compound packet as well as preparation method and application thereof Effective date of registration: 20180515 Granted publication date: 20130529 Pledgee: Bank of Changsha Limited by Share Ltd HSBC branch Pledgor: Changsha Xingjia Bio-engineering Co., Ltd. Registration number: 2018430000031 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20200619 Granted publication date: 20130529 Pledgee: Bank of Changsha Limited by Share Ltd. HSBC branch Pledgor: CHANGSHA XINGJIA BIO-ENGINEERING Co.,Ltd. Registration number: 2018430000031 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Saving trace element compound packet as well as preparation method and application thereof Effective date of registration: 20200630 Granted publication date: 20130529 Pledgee: Bank of Changsha Limited by Share Ltd. HSBC branch Pledgor: CHANGSHA XINGJIA BIO-ENGINEERING Co.,Ltd. Registration number: Y2020980003606 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20201229 Granted publication date: 20130529 Pledgee: Bank of Changsha Limited by Share Ltd. HSBC branch Pledgor: CHANGSHA XINGJIA BIO-ENGINEERING Co.,Ltd. Registration number: Y2020980003606 |