CN105724779A - Compound feeding composition and application of compound feeding composition in preparation of animal feed additive - Google Patents
Compound feeding composition and application of compound feeding composition in preparation of animal feed additive Download PDFInfo
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- CN105724779A CN105724779A CN201610098674.9A CN201610098674A CN105724779A CN 105724779 A CN105724779 A CN 105724779A CN 201610098674 A CN201610098674 A CN 201610098674A CN 105724779 A CN105724779 A CN 105724779A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
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Abstract
The invention provides a compound feeding composition and application of the compound feeding composition in preparation of an animal feed additive. The compound feeding composition contains butyric acid derivatives, myristic acid derivatives and benzoate, has a quite remarkable improving effect on animal production performance in animal breeding, can prevent and treat diarrhea symptoms of animals, achieves or exceeds the acting effects of traditional feeding antibiotics and high-copper or high-zinc feed additives, and can be used as a novel, safe and efficient feed additive for animal breeding.
Description
Technical field:
The invention belongs to animal feed additive field, relate to a kind of feeding compositions of compound recipe containing butanoic acid derivative, myristic acid derivant and benzoate and the application in preparing animal feed additive thereof.
Background technology:
The animal basal diet that animal feed is required at present substitutes traditional original agricultural product and applies in animal cultivation.People are often desirable to the animal growth at the minimum feedstuff efficient and healthful of the shortest time loss.In order to reach this purpose, the feed additive of various functions adds preparation in feedstuff in feed manufacturing process and becomes functional feed.Wherein, feeding antibiotic, zinc oxide or copper sulfate etc. are that the feed additive commonly used in the past is for improving the production performance of animal and preventing and treating Animal diseases.But animal is virose and suppresses growth of animal by the life-time service of high dose inorganic zinc or Inorganic Copper class feed additive；And the abuse of feeding antibiotic also leads to the generation of microorganism drug resistance, drug residue and drug resistance transmission and human health is threatened.The appearance of these problems causes that conventional feed additive uses in animal cultivation and is restricted or disables.Therefore, animal farming industry is had great importance by the efficient feed additive of the safety of development of new.
Summary of the invention:
It is an object of the invention to provide the feeding compositions of compound recipe and the application in preparing animal feed additive novel, safe and efficient thereof, especially as the animal application with diarrhea type feed additive and animal growth promoter.
One of effective ingredient that the feeding compositions of compound recipe provided by the invention relates to is benzoate.
Existing patent once being reported, benzoate can prevent or alleviate the urinary stone disease shape of ruminant or share the excremental acid number of reduction with other ammonium carboxylate salt, reduce the discharge of ammonia in Excreta, but by the complicated cud metabolic degradation easily of ruminant, and Excreta gas discharging will be controlled by restriction for swine rearing because those skilled in the art imagine benzoic acid.
The present inventor finds to be united and applied in the raising of cultivated animals by carboxylic acid derivates and benzoate in research process first to the control of animal diarrhea rate and produces the improvement of performance and have the effect of highly significant, reaches the level of conventional feeding antibiotic and the feed additive such as Pharmacological Level of Zinc preparation or copper agent.
Carboxylic acid derivates described in above-mentioned use in conjunction comprises butanoic acid derivative and myristic acid derivant.
The feeding compositions of compound recipe provided by the invention contains butanoic acid derivative, myristic acid derivant and benzoate.
The butanoic acid derivative that the present invention relates to is butyrate or its structure such as shown in formula I or its structure such as shown in formula II:
(A)
Wherein, M is selected from H, alkali metal；Alkali metal ion includes Na, K, Li etc..
(B)
Wherein, M is selected from alkaline-earth metal, Zn, Fe, Mn, Cu；Alkaline-earth metal ions includes Ca, Mg, Be etc..
(C)
Shown in described butyrate its structure such as formula III or formula IV:
Described R1Selected from C1-4Straight or branched alkyl；
Wherein, R2、R3And R4Selected from H and straight chain C3C (=O), and R2、R3And R4It is not all H；
Monovalent metallic ion butyrate in above-mentioned butyrate can pass through dry preparation after butanoic acid occurs conventional acid-base neutralization to react with corresponding alkali.Bivalent metal ion butyrate in above-mentioned butyrate first passes through butanoic acid and sodium hydroxide generation routine neutralizes after reacting generation sodium butyrate, dries preparation through precipitate and separate after further carrying out metathesis reaction with the chloride of bivalent metal ion.
Above-mentioned butyrate can through perbutyric acid and corresponding C1-4After straight or branched alkanol, glycerol become ester under enzymatic synthesis condition prepared by rectification.
The myristic acid derivant that the present invention relates to is shown in myristinate or its structure such as formula (V) or its structure is such as shown in formula VI:
(D)
Wherein, M is selected from H, alkali metal；Alkali metal ion includes Na, K, Li etc..
(E)
Wherein, M is selected from alkaline-earth metal, Zn, Fe, Mn, Cu；Alkaline-earth metal ions includes Ca, Mg, Be etc..
(F)
Shown in its structure of described myristinate such as formula (VII) or formula (VIII):
Described R5Selected from C1-4Straight or branched alkyl；
Wherein, R6、R7And R8Selected from H and straight chain C13C (=O), and R6、R7And R8It is not all H；.
Monovalent metallic ion myristate in above-mentioned myristate can pass through dry preparation after myristic acid occurs conventional acid-base neutralization to react with corresponding alkali.Bivalent metal ion myristate in above-mentioned myristate first passes through myristic acid and sodium hydroxide generation routine neutralizes after reacting generation Sodium myristate, dries preparation through precipitate and separate after carrying out metathesis reaction with the chloride of bivalent metal ion further.
Above-mentioned myristinate can through myristic acid and corresponding C1-4After straight or branched alkanol, glycerol become ester under enzymatic synthesis condition prepared by rectification.Gained myristinate can be rendered as solid-liquid different conditions at different temperatures.
The benzoate that the present invention relates to is selected from sodium benzoate, Potassium Benzoate or calcium benzoate, it is preferred to calcium benzoate.
Described benzoate is that benzoic acid reacts with corresponding alkali such as sodium hydroxide, potassium hydroxide or calcium hydroxide generation acid-base neutralization, and concentration of reaction solution removes solvent to be prepared.
The feeding compositions of compound recipe that the present invention also provides for containing butanoic acid derivative, myristic acid derivant and benzoate is preparing the application of additive for animal feed.
The present invention is by it have been experienced that constitute jointly feeding compositions by butanoic acid derivative, myristic acid derivant and butanoic acid derivative by suitable mass ratio and not only can effectively control the various diarrhoea of cultivated animals but also can reach breeding performonce fo animals optimization.
Preferably, the feeding compositions of described compound recipe, according to the mass fraction, including butanoic acid derivative 2-12 part, myristic acid derivant 2-4 part and benzoate 20-80 part.
In an animal cultivation scheme, individually give and cultivated animals butanoic acid derivative, along with the feed intake of the buildup tests animal of dosage increase accordingly, animal diarrhea incidence rate declines.
In another animal cultivation scheme, individually giving and cultivated animals myristic acid derivant, the production performance improvement effect of animal is very notable but animal feed intake does not increase significantly, and diarrhea rate is more not notable than effect with the calcium butyrate of the Isodose of another cultivation scheme.
In another animal cultivation scheme, individually give and cultivated animals benzoate, decline to some extent along with giving the diarrhea rate raising cultivated animals with dosage, the production performance of animal makes moderate progress, but the diarrhea rate of animal occurs almost all effectively to control and intended lifting effect does not occur in the production performance of animal in dosage is up to more than 8000ppm benzoate test group.
In another animal cultivation scheme, feeding for the compound recipe that the present invention relates to compositions is applied to the raising of different types of cultivated animals, the improvement effect of the feed intake of cultivated animals and the production performance of animal is notable, and additionally the diarrhea rate of cultivated animals is well controlled and shows that feces molding and stink are controlled.
In another animal cultivation scheme, the feeding compositions of compound recipe that the present invention relates to is applied to possibly together with other trace substances needed for other Animal nutritions the cultivation of animal.
In another embodiment, this feeding compositions further comprises and supplements and balanced nutrients class material.
In another embodiment, this feeding compositions further comprises health-related material.
In another embodiment, this feeding compositions further comprises physiological regulation metabolism class material.
In another embodiment, this feeding compositions further comprises the increasing aid digestion class material of appetite.
In another embodiment, this feeding compositions further comprises processing and preservative agent class material.
In another embodiment, this feeding compositions can be liquid, solid, semisolid, gel etc..
" containing " of the present invention, " including " or " comprising " are open language, both included the present invention the content of bright finger, but be not precluded from otherwise content.
Further, the feeding compositions of compound recipe containing butanoic acid derivative, myristic acid derivant and benzoate is used for preparing additive for animal feed by the present invention, except described feeding compositions is possibly together with pharmaceutically acceptable excipient, carrier, antioxidant, diluent, anti-caking agent, solvent or their combination.
Described feed additive can add in feed processing industry in feedstuff according to formula forage demand be successfully prepared can property feed applications in the raising of cultivated animals.
Described functional feed can maintain the healthy production performance improving animal on the other hand of animal on the one hand.
It addition, the invention still further relates to the present invention to provide the purposes in preparing diarrhea type feed additive and animal growth promoter of the feeding compositions of compound recipe containing butanoic acid derivative, myristic acid derivant and benzoate.
Described animal feed additive is applied to animal cultivation and has significant effect in improving efficiency of feed utilization, improving the production performance of animal, stimulating animal growth.
Described animal feed additive can substitute the application of feeding antibiotic class animal growth promoting agent further.
Described animal feed additive also can substitute the application as animal growth promoting agent of high dose zinc oxide or copper sulfate further.
In one embodiment, the feeding compositions of compound recipe containing butanoic acid derivative, myristic acid derivant and benzoate provided by the invention or the additive for animal feed prepared by said composition add to independent form in every daily sustenance of animal and use.
In another embodiment, feeding compositions containing butanoic acid derivative, myristic acid derivant and benzoate provided by the invention or the additive for animal feed prepared by said composition prepare into the Feed forms such as additive premix, concentrated feed, mixed feed, beneficiated burden material complemental feed according to a certain percentage for animal edible with feedstuff, feed additive, carrier or diluent etc..
The feedstuff that the present invention relates to refers to and derives from animal, plant, microorganism or mineral, for processing and fabricating feedstuff but be not belonging to the feeding material of feed additive.
The feed additive that the present invention relates to refers at a small amount of or trace substance that feed manufacturing, making, use procedure are added, including nutritional feed additive and non-nutritional feed additive.Nutritional feed additive refers to a small amount of or trace substance mixing in feedstuff for supplement feed nutritional labeling, including feed grade aminoacid, vitamin, mineral trace element, enzyme preparation, non-protein nitrogen etc..Non-nutritional feed additive refers to a small amount of or trace substance for ensureing or improve feed quality, improve the effects such as efficiency of feed utilization and mixing in feedstuff.
The carrier that the present invention relates to refers to carrying active component, improves its dispersibility, and have good chemical stability and an adsorptivity can feeding material.
The diluent that the present invention relates to refers to and is uniformly distributed in material by additive raw material, the additive raw material of high concentration is diluted the material of the pre-mixing agent for low concentration or premix material, micro constitutent can be separated from each other, reduce reacting to each other between active component, to increase the stability of active component but not affect the physico-chemical property having related substance.
The additive premix that the present invention relates to refers to that the nutritional feed additive more than by two kinds (classes) or two kinds (class) is main, the feedstuff prepared according to a certain percentage with carrier or diluent, including compound premixed feed, trace element premixing feed, vitamin premixed feed.
The concentrated feed that the present invention relates to refers to the feedstuff mainly having protein, mineral and feed additive to prepare according to a certain percentage.
The mixed feed that the present invention relates to refers to according to cultivated animals nutritional need, the feedstuff multiple feedstuff and feed additive prepared according to a certain percentage.
The concentrate supplement that the present invention relates to refers to the nutrition into supplementary plant-eating animal, the feedstuff multiple feedstuff and feed additive prepared according to a certain percentage.
Additionally, the cultivated animals that the feeding compositions of compound recipe provided by the invention or additive agent for feeding prepared therefrom or animal growth promoting agent are suitable for includes domestic animal, poultry and aquatic animal etc., especially more notable in the control effect of the diarrhea of poultry and dyspepsia etc..
In another embodiment, the feeding compositions of compound recipe containing butanoic acid derivative, myristic acid derivant and benzoate provided by the invention or the additive for animal feed prepared by said composition for the broiler of each growth stage, laying hen, hen, meat-type duck, laying ducks, goose, turkey, guinea fowl, Columba livia, Carnis Coturnicis japonicae and other can the raising of birds of artificial breeding.
In another embodiment, the feeding compositions of compound recipe containing butanoic acid derivative, myristic acid derivant and benzoate provided by the invention or additive agent for feeding prepared therefrom or animal growth promoting agent etc. for the beef cattle of each growth stage, milch cow, pig, support, horse, rabbit, Canis familiaris L., the domestic animal such as cat and donkey raising.
In another embodiment, the feeding compositions of compound recipe containing butanoic acid derivative, myristic acid derivant and benzoate provided by the invention or additive agent for feeding prepared therefrom or animal growth promoting agent etc. are for the raising of the aquatic animals such as the fish of each growth stage, shrimp, Chinese yellow eel, Eriocheir sinensis or Misgurni anguillicaudati.
In sum, provided by the invention containing butanoic acid derivative, the feeding compositions of compound recipe of myristic acid derivant and benzoate or the additive for animal feed prepared by said composition are a kind of novel, safety, efficient animal feed additive, substitute the application of feeding antibiotic class animal growth promoting agent and high dose zinc oxide or copper sulfate, overcome the drug resistance that feeding antibiotic causes in animal farming industry, the impact that animal health and human food are caused safely by other toxic and side effects such as drug resistance transmission and heavy metal preparation prolonged application, animal farming industry has large market prospect.
Detailed description of the invention:
In order to describe the present invention, it is listed below embodiment.But it is to be understood that the invention is not restricted to these embodiments, only it is to provide the method putting into practice the present invention.
Butanoic acid derivative, myristic acid derivant and the benzoate that following example of the present invention use provides by the research and development centre of Guangzhou Insighter Biotechnology Co., Ltd., sample purity >=99%；Virginiamycin preparation used is import pre-mixing agent, factory of Belgium of Hui Bao company limited of the U.S. produce；Colistine sulfate used is produced by Shandong, Shandong drug resistance industry.
The feeding compositions of compound recipe of the present invention, its preparation method is as follows:
According to the mass fraction of each component, obtain the feeding compositions of compound recipe by after butanoic acid derivative, myristic acid derivant and benzoate mix homogeneously.May then act as animal feed additive to add in animal feed.
Embodiment 1: butanoic acid derivative, myristic acid derivant and the benzoate application effect in wean pig feed
The wean pig of 170 28 age in days average weight 7.61kg, the assorted lean meat species piglets of DLY ternary such as 1 point 17 groups of table that body weight is close, often group 10.Each group after conventional creep feed (without any medicated feed additive, zinc oxide and high copper agent) middle interpolation difference test additive, free choice feeding and drinking-water, the average daily ingestion amount (ADF) of each test group test pig, average daily gain (ADG), the price of deed and diarrhea rate in adding up 10 days.Result is as shown in table 1, as it can be seen from table 1 in test pig diarrhea rate control, the butanoic acid derivative of 800ppm compares the common dose more remarkable effect of sulphuric acid Bacillus adhaerens, virginiamycin at the diarrhea rate of Control experiment pig, there is similar effect to benzoate, although dosage used is different；It addition, in growth of animal performance improvement, myristic acid derivant compares the colistine sulfate of common dose and virginiamycin, butanoic acid derivative or benzoate action effect are more notable.
Impact and the health-care effect of the growth performance of wean pig are studied by table 1 butanoic acid derivative, myristic acid derivant and benzoate
Embodiment 2: compound recipe feeding compositions action effect in wean pig feed
The assorted lean meat species ablactational baby pig of DLY ternary that 90 28 age in days body weight are close is divided into 9 groups, often group 10.Each group is added test additive as shown in table 2 and corresponding dosage in the creep feed without any feed additive, wherein positive controls adds the common feedstuffs compositions of additives containing zinc oxide 3000ppm, copper sulfate 800ppm, virginiamycin 20ppm and colistine sulfate 20ppm in creep feed, free choice feeding and drinking-water during test, the average daily gain (ADG) of each test group test pig, the price of deed and diarrhea rate in adding up 10 days.Result shows (table 2), containing myristate, the diarrhea rate of test pig is had the good production performance controlling effect and improving test pig by the feeding compositions of compound recipe of biological, butanoic acid derivative and benzoate, has met and exceeded the level of positive controls.
Table 2 calcium butyrate and the calcium myristate use in conjunction effect in weaning pigs
Embodiment 3: compound recipe feeding compositions application effect in chicken material.
1800 plumage 1 age in days big yellow-feather broilers soon are randomly divided into 9 test group, each test group comprises 4 parallel test groups, each parallel test group is 50 plumages, and is often organizing the additive adding corresponding dosage as shown in table 3 in feedstuff respectively, and wherein positive controls additive is virginiamycin 20ppm.Experimental period, raises in cages, free choice feeding and freely drinking water, totally 28 days experimental period, the average daily gain (ADG) of each test group test chicken, average feedstuff-meat ratio (AFCR) and survival rate in adding up 28 days.Result of the test shows, the raising to breeding performonce fo animals in broiler breeding of the feeding compositions of compound recipe of different ratio, compared to the use in conjunction group of blank group, calcium myristate group, calcium myristate and calcium butyrate or calcium benzoate, there is obvious action effect, met and exceeded the level (table 3) of positive controls.
Table 3 compound recipe feeding compositions use in conjunction effect in broiler material
Embodiment 4: compound recipe feeding compositions use in conjunction effect in Ctenopharyngodon idellua feed
Test fish used is Ctenopharyngodon idellus, Aquatic product field, English Saite test site, Guangzhou carry out.The Mylopharyngodon piceus kind that bouncing, specification are consistent is just for formal culture experiment after raising in large cage 4 weeks, and experimental system is buoyancy small-sized net cage.Small-sized net cage is placed in one, test site 3500m with foster net cage temporarily2Pond in, the pond depth of water～1.5m, pond water is water under abundant aeration.During test, Ctenopharyngodon idellus 200 tail of hungry 1d being randomly divided into 5 groups, often group sets 4 repetitions, and each repetition puts 10 tail fishes, and entirety is put into after weighing in 16 net cages at random, feeds different test feeds respectively.Test feedstuff is prepared voluntarily by formula, and different tests group is by the feeding compositions of compound recipe containing calcium myristate, calcium butyrate and calcium benzoate being separately added into various dose in basestocks.Test adopts artificial limit food to throw something and feed, and feeding amount adjusts weekly once, and two groups of levels of throwing something and feeding (by original body mass) are completely the same, and throw something and feed every day twice (7:30 and 15:00).Test 8 weeks by a definite date.The feeding compositions of compound recipe to the growth promotion result of the test of fish in Table 4.The test group of the feeding compositions of compound recipe that various dose is added in result display is superior to matched group in weightening finish, feed coefficient and survival rate, has obvious growth enhancing effect.
Table 4 compound recipe feeding compositions application test in Ctenopharyngodon idellua feed is grouped and result
Above-described embodiment is the present invention preferably embodiment; but embodiments of the present invention are also not restricted to the described embodiments; the change made under other any spirit without departing from the present invention and principle, modification, replacement, combination, simplification etc. all should be the substitute mode of equivalence, are included within protection scope of the present invention.
Claims (9)
1. the feeding compositions of compound recipe, it is characterised in that include butanoic acid derivative, myristic acid derivant and benzoate；
Described butanoic acid derivative is butyrate or its structure such as shown in formula I or its structure such as shown in formula II:
(A)
Wherein, M is selected from H, alkali metal；
(B)
Wherein, M is selected from alkaline-earth metal, Zn, Fe, Mn, Cu；
(C)
Shown in described butyrate its structure such as formula III or formula IV:
Described R1Selected from C1-4Straight or branched alkyl；
Wherein, R2、R3And R4Selected from H and straight chain C3C (=O), and R2、R3And R4It is not all H；
Described myristic acid derivant is shown in myristinate or its structure such as formula (V) or its structure is such as shown in formula VI:
(D)
Wherein, M is selected from H, alkali metal；
(E)
Wherein, M is selected from alkaline-earth metal, Zn, Fe, Mn, Cu；
(F)
Shown in its structure of described myristinate such as formula (VII) or formula (VIII):
Described R5Selected from C1-4Straight or branched alkyl；
Wherein, R6、R7And R8Selected from H and straight chain C13C (=O), and R6、R7And R8It is not all H；
Described benzoate is selected from sodium benzoate, Potassium Benzoate and calcium benzoate.
2. the feeding compositions of compound recipe according to claim 1-, it is characterised in that according to the mass fraction, including butanoic acid derivative 2-12 part, myristic acid derivant 2-4 part and benzoate 20-80 part.
3. the application in preparing animal feed additive of the feeding compositions of compound recipe described in claim 1 or 2.
4. application according to claim 3, it is characterised in that described animal feed additive is animal diarrhea type feed additive.
5. application according to claim 3, it is characterised in that described animal feed additive is animal growth promoter.
6. application according to claim 3, it is characterised in that described animal is the domestic animal of each growth stage, poultry or aquatic animal.
7. application according to claim 6, it is characterised in that described domestic animal is the pig of each growth stage, cattle, sheep, horse, rabbit, Canis familiaris L., cat or donkey.
8. application according to claim 6, it is characterised in that described poultry is the chicken of each growth stage, turkey, guinea fowl, duck, goose, Columba livia or Carnis Coturnicis japonicae.
9. application according to claim 6, it is characterised in that described aquatic animal is the fish of each growth stage, shrimp or Eriocheir sinensis.
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| PCT/CN2016/081813 WO2017143665A1 (en) | 2016-02-23 | 2016-05-12 | Compound feeding composition and application thereof in preparation of animal feed additive |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108041349A (en) * | 2017-12-26 | 2018-05-18 | 重庆医学检验试剂研究所 | A kind of pharmaceutical composition for promoting aquatic livestock growth and its reagent and method |
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| CN115067436B (en) * | 2022-08-22 | 2022-11-22 | 山东畜牧兽医职业学院 | Preparation method of special feed additive for breeding fattening meat ducks |
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- 2016-02-23 CN CN201610098674.9A patent/CN105724779A/en active Pending
- 2016-05-12 WO PCT/CN2016/081813 patent/WO2017143665A1/en active Application Filing
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| CN1437467A (en) * | 2000-06-20 | 2003-08-20 | 营养科学公司 | Medium chain fatty acids applicable as anitmicrobial agents |
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| CN108041349A (en) * | 2017-12-26 | 2018-05-18 | 重庆医学检验试剂研究所 | A kind of pharmaceutical composition for promoting aquatic livestock growth and its reagent and method |
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| WO2017143665A1 (en) | 2017-08-31 |
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