CN105076726A - Butyrate, butyrate derivative and benzoic acid compound formula, preparation method and application of butyrate, butyrate derivative and benzoic acid compound product as feed additive - Google Patents
Butyrate, butyrate derivative and benzoic acid compound formula, preparation method and application of butyrate, butyrate derivative and benzoic acid compound product as feed additive Download PDFInfo
- Publication number
- CN105076726A CN105076726A CN201510559576.6A CN201510559576A CN105076726A CN 105076726 A CN105076726 A CN 105076726A CN 201510559576 A CN201510559576 A CN 201510559576A CN 105076726 A CN105076726 A CN 105076726A
- Authority
- CN
- China
- Prior art keywords
- butyrate
- benzoic acid
- derivative
- acid
- butyric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Fodder In General (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a butyrate, butyrate derivative and benzoic acid compound formula, a preparation method and an application of the butyrate, butyrate derivative and benzoic acid compound product as a feed additive. The weight ratio of butyrate or a butyrate derivative and benzoic acid or benzoate is 5%-50% and 50%-95%. With the adoption of the scheme, benzoate and butyrate enter an animal body and are dissociated into acidic molecules, butyric acid stimulates growth of parietal cells, parietal cells produce hydrochloric acid reducing pH value in the stomach, benzoic acid in the stomach inhibits facultative anaerobes such as lactobacillus and anaerobes producing butyric acid, and the two groups of bacterial communities become dominant bacterial communities, generate more endogenous organic acid such as lactic acid and butyric acid and are beneficial to gastrointestinal tract health and animal growth, so that the superimposed effect of benefits of the two components is realized.
Description
Technical field
The present invention relates to a kind of feed feed additives field, particularly regulate the feed addictive of animal stomach microorganism species.
Background technology
Sodium butyrate (or butyrate and other butanoic acid derivatives) can be animal body and histocyte thereof and provides quick and be easy to the energy source that absorbs, its active ingredient is a kind of short chain volatile aliphatic acid---butyric acid, butyric acid molecule works its especially energy of having a preference for of enterocyte (caecum and colon cell) from stomach enters small intestine, it is the epithelial main energy sources of colonic mucosa, account for 70% of SCFA oxygen consumption institute production capacity, and very easily absorb in enteric cavity, betaoxidation in enterocyte butyric acid is circulated by HMG CoA carries out energetic supersession, first be, by butyric acid CoA synthase, butyric acid is changed into butyric acid coacetylase, then generate acetyl coenzyme A fast by series reaction and carry out energetic supersession.The animal that short chain volatile aliphatic acid (SCFA) is metenteron prosperity provides the maintenance energy up to 30%.And then increase intestinal villus film! Sodium butyrate adjustable animal gastrointestinal tract microecological balance, promotes the growth of beneficial bacterium in intestines and stomach, suppresses the growth of harmful bacteria, thus makes micro ecology of gastrointestinal tract be in positive balance.An extremely important feature of normal gastrointestinal tract is the coordinated balance of inner bacterium, especially cub.In vitro study shows: with glucose, ketoboidies, glutamine etc. as when breathing the energy, first colon epithelial cell utilizes butyric acid.Nearly all butyric acid can be absorbed by enterocyte, and isotope is followed the tracks of and found, butyric acid can enter the total blood circulation of people, nearly all soma can metabolism butyric acid, in peripheral tissues, butyric acid can be used for Fatty synthesis by rapid oxidation, also can enter mammary gland synthesis butterfat.
People such as Buhler 2009 research finds, feed add 0.5% benzoic acid significantly improve growth period pig caecum and rectal contents in butyric acid content, European Union allows the addition of benzoic acid in growing-finishing pig diet to be 0.5-1.0%.The regulation although China does not limit the quantity, use as acidulant, benzoic addition is also recommended as 0.5-1.0%.
What patent No. WO2009068622A1 described is a kind of phagostimulant, include 0.05-0.25% benzoic acid, 0.25-1% butyric acid benzyl, and the mixture of 0.2-2% butyric acid and ester etc. thereof, but it belongs to essence and flavoring agent prescription category.
Existing technology is adds sodium butyrate separately in feed, it is made to enter generation effect after enteron aisle by coating technique, but lack hydrogen ion at rear intestinal segment, enough butyric acid molecules cannot be formed, but too much butyric acid can not be added receive, receive also can affect GI balance because add too much butyric acid.Therefore still need to find animal own metabolism to produce a large amount of butyric acid and carry out satisfied growth demand.
In prior art, the addition of benzoic acid in feed is 0.5-1%, the addition of compound product of the present invention in feed is 0.1 ~ 0.5%, in benzoic acid maximum level 95%, the amount of adding at feed is less than 0.5%, although prior art give benzoic acid can improve growth period pig caecum and rectal contents in butyric acid content, but do not provide the prompting that benzoic acid and butyric acid mutually play facilitation in animal stomach, namely butyric acid reduces hydrochloric acid in gastric juice pH value, benzoic acid promotes the flora growth producing butyric acid, and all adopt bag by form in existing butyric acid application, butyric acid is made to be applied to animal caecum and rectum quickly through animal stomach, be beneficial to animal and absorb energy.Therefore butyric acid of the present invention and benzoic acid do not provide relevant art in the prior art in the synergistic effect that animal stomach produces and point out.
Also the Overlay brought after demonstrate,proving employing technical solution of the present invention by other feeding trial.
Summary of the invention
The object of the present invention is to provide a kind of butyrate and derivative thereof and benzoic acid compound prescription.
Another object of the present invention is to the application providing a kind of butyrate and derivative and benzoic acid compound prescription thereof as feed addictive.
Another object of the present invention is to the preparation method that butyrate and derivative and benzoic acid compound prescription are provided.
For reaching above-mentioned purpose, butyrate of the present invention and derivative thereof and benzoic acid compound prescription, wherein, comprise the butyrate of weight accounting 5-50% or the benzoic acid of butanoic acid derivative and weight accounting 50-95% or benzoate.
The excipient of weight accounting 0-45% is also comprised in described compound prescription.
Described butyrate is the complex of one or more in sodium butyrate, potassium butyrate, calcium butyrate, magnesium butyrate etc.
Described excipient is syrup, dextrin, whey powder, starch, water-soluble dietary fiber, shitosan etc.
Butyrate and derivative thereof and benzoic acid compound product are as the application of feed addictive, weight accounting 0.1-0.5% butyrate and benzoic acid compound product is added as additive in feed, butyrate and benzoic acid compound product enter animal stomach simultaneously and are dissociated into butyric acid molecule and benzoic acid molecule, butyric acid stimulates parietal cell growth, parietal cell produces hydrochloric acid, hydrochloric acid reduces stomach inner pH value, reach the optimal pH 2.5-4.0 of benzoic acid anti-corrosive antibacterial, the anaerobic bacteria producing butyric acid is made to become dominant microflora to group, produce more endogenous organic acid as lactic acid and butyric acid, thus butyric acid is played with benzoic acid beneficial effect superpose.
The preparation method of butyrate and derivative and benzoic acid compound product, adds water in retort, under agitation adds hydroxide, stirs fully to dissolving, then adds benzoic acid gradually, stirring reaction, dissolving; Continue under agitation to add butyric acid, by adding control temperature not higher than 105 DEG C, generate the mixed liquor of butyrate and benzoic acid (salt), reaction terminates, and cooling reactant liquor is to temperature 60 C ~ 90 DEG C; Commissioning pH value again, adds appropriate butyric acid or basic salt, commissioning reacting liquid pH value to 8 ~ 10; Then, under agitation in the reactant liquor of retort, add dextrin, stirring and dissolving or in suspension; Continue cooling reactant liquor to temperature 25 DEG C ~ 50 DEG C; Then EAT 150 DEG C ~ 260 DEG C, spraying dry is carried out under leaving air temp 65 DEG C ~ 160 DEG C conditions, finally, through the dry powder that cyclone separator or vibrated fluidized bed are collected, obtain the butyrate of 60-200 order spherical particles more than 95% and benzoic acid (salt) microspheric particle.
Adopt benzoate after such scheme to enter animal body internal disintegration with butyrate and become acidic molecular, butyric acid stimulates parietal cell growth, parietal cell produces hydrochloric acid, hydrochloric acid reduces stomach inner pH value, adjustment animal stomach inner pH value is less than 4, and the optimal pH of benzoic acid anti-corrosive antibacterial is 2.5-4.0, Antifungi in stomach, mould and facultative anaerobe, and these two groups of floras of anaerobic bacteria of Bacillus acidi lactici (Lactobacillus) and generation butyric acid become dominant microflora, produce more endogenous organic acid as lactic acid and butyric acid, be conducive to gastrointestinal health and growth of animal, thus reach the synergistic effect of two kinds of composition beneficial effects.
Detailed description of the invention
By describing technology contents of the present invention, structural feature in detail, being realized object and effect, be explained in detail below in conjunction with embodiment.
The content of butyrate of the present invention and derivative and benzoic acid compound prescription butyrate or derivative: 5%-50%; Butyrate refers to: the butanoic acid derivatives such as the complex of one or more in sodium butyrate, potassium butyrate, calcium butyrate, magnesium butyrate etc. or glycerol monobutyralte; The content 50-95% of benzoic acid (sodium), other are 10-20% excipient, and excipient is: syrup, dextrin, whey powder, starch, shitosan etc.
For the production technology of sodium butyrate and benzoic acid (sodium) butyrate of the present invention and derivative and benzoic acid compound product be:
First acid-base reaction: the water adding 1371,1601,1852,1445 weight portions in four retort (four examples) respectively, under agitation add the NaOH of 321,268,283,158 weight portions respectively, stir fully to dissolving, the benzoic acid adding 424,594,805,424 weight portions more gradually enters retort, stirring reaction, dissolving.The butyric acid continuing under agitation to add respectively 400,160,40,40 weight portions enters retort, and by adding control temperature not higher than 105 DEG C, generate the mixed liquor of sodium butyrate and Sodium Benzoate, reaction terminates, and cooling reactant liquor is to temperature 60 C ~ 90 DEG C.
Commissioning pH value again, adds appropriate butyric acid or the basic salt containing sodium, commissioning reacting liquid pH value to 8 ~ 10.
Then, under agitation toward second and the 4th retort reactant liquor in add the dextrin of 100,450 weight portions respectively, stirring and dissolving or in suspension.
Continue cooling reactant liquor to temperature 25 DEG C ~ 50 DEG C.
Then, spraying dry: EAT 150 DEG C ~ 260 DEG C, carry out spraying dry under leaving air temp 65 DEG C ~ 160 DEG C conditions, concrete drying condition sees the following form; Meanwhile, carry out moisture film, spraying and dedusting to the gas producing evaporation in spraying dry, dedusting liquid is recycled.
Finally, through the dry powder that cyclone separator or vibrated fluidized bed are collected, obtain sodium butyrate and Sodium Benzoate microspheric particle, in four groups of examples, in product, sodium butyrate content is respectively 50%, 20%, 5% and 5%, Sodium Benzoate content is respectively 50%, 70%, 95% and 50%, and dextrin content is respectively 0%, 10%, 0%, 45%.
Also direct Sodium Benzoate can be adopted to add water in production technology miscible with butyrate reactant liquor, form the mixed solution of butyrate and benzoic acid (sodium), or add or do not add excipient, be formed the microspheric particle of stable homogeneous by spraying dry.
Nursing test is carried out to products obtained therefrom:
120 21 age in days weanling pigs are divided into 12 groups, often organize 10, administering transgenic group 9 kinds of daily rations and control group 3 kinds of daily rations, feed 21 days continuously respectively, detects Wei Misuan district gland walls cell quantity, stomach and jejunum butyric acid content respectively, and every daily gain in pigs.
Result shows: (1) adds 0.3% sodium butyrate and composite group of Sodium Benzoate exceedes the effect of adding separately 0.5% Sodium Benzoate.(2) add 0.15% sodium butyrate and composite group of Sodium Benzoate and can meet or exceed the effect of adding separately 0.15% sodium butyrate.(3) be no matter add sodium butyrate or Sodium Benzoate, or both composite group, stomach pH is low than control group 0.Composite group has the trend of reduction than independent control group.(4) be no matter add sodium butyrate or Sodium Benzoate, or both composite group, ileum clostridium butyricum content is all high than control group 0.Composite group has the trend of increase than independent control group.(5) be no matter add sodium butyrate or Sodium Benzoate, or both composite group, parietal cell and ileum butyric acid content are all high than control group 0.(6) ileum is body major absorption site, and butyric acid, except affecting by feed addictive amount, is more the result that multiple anaerobe fermentation produces.All experimental group are all high than control group 2 ileum butyric acid content.
After feed adds butyric acid and benzoic acid compound product, enter animal stomach internal disintegration and become acidic molecular, butyric acid stimulates parietal cell growth, parietal cell is the cell anaerobic bacteria producing hydrochloric acid, parietal cell produces more hydrochloric acid, hydrochloric acid reduces stomach inner pH value, and benzoic acid only especially acts on just obvious under sour environment when being less than 4.Benzoic acid suppresses microorganism by following three kinds of modes: the enzyme system of (1) interference microorganism, destroys that it is metabolic normally, the activity of inhibitory enzyme.(2) make the albumen of microorganism query solid and sex change, disturb its existence and breeding.(3) change cytoplasm permeability of the membrane, make the enzyme in its body and metabolite effusion cause its inactivation.Benzoic acid suppresses the mould taken in by feed and fungi.Facultative anaerobe (facultativeaerobes) such as the member of the enterobacteriaceaes (Enterobacteriaceae) such as Escherichia coli (E.coli), clostridium perfringen (Enterobacteraerogenes), bacillus licheniformis (Bacilluslichenifornus) and saccharomyces cerevisiae (Saccharomycescerevisiae) are suppressed.Facultative anaerobe enters stomach with feed direct oral cavity.Animal stomach inner pH value is less than 4, and the optimal pH of benzoic acid anti-corrosive antibacterial is 2.5-4.0, in stomach, suppress facultative anaerobe.Anaerobic bacteria anaerobic bacteria such as ButyrinumFlavonifractorplautii, Peptoniphilusgorbachii, Eubacteriumnodatum, Megasphaeraelsdenii, Eubacteriumhadrum, Roseburiafaecis, Roseburiahominis, Clostridiumbutyricum (clostridium butyricum) as Bacillus acidi lactici (Lactobacillus) and generation butyric acid then become dominant microflora, produce more endogenous organic acid as lactic acid and butyric acid, be conducive to gastrointestinal health and growth of animal.
Butyric acid and benzene Party A acid compound prescription is adopted in the present invention; butyric acid stimulates dynamic special parietal cell growth; produce more hydrochloric acid; hydrochloric acid reduces stomach inner pH value, and for the effect of benzoic acid anti-corrosive antibacterial provides best sour environment, and benzoic acid can suppress non-acidophilic bacteria as Salmonella and Escherichia coli; acidophilic bacteria such as clostridium butyricum is made to become dominant microflora; produce more butyric acid, both effects serve the synergistic effect of 1+1>2, and this is the content that the present invention will protect.
Case study on implementation 1
The healthy weanling pig of 72 28 ages in days, be divided into A, B two experimental group at random, A group is test group, and B group is control group, often organizes each 36 weanling pigs.Test group feed per ton of feeding adds 3 kilograms (sodium butyrate content is 50%, and Sodium Benzoate content is 50%, and dextrin content is 0% by formula 1.) product made, control group fed feed per ton adds the daily ration of 60ppm salinomycin.Draw the impact on weanling pig nutritive digestibility, result is as follows:
| Project | Test group | Control group |
| Energy | 83.24 | 80.85 |
| Dry | 95.21 | 94.16 |
| Thick protein | 82.95 | 81.98 |
| Phosphorus | 45.25 | 44.11 |
| Calcium | 47.74 | 46.80 |
Result shows: 1 product of 1, filling a prescription improves the nutritive digestibility of weanling pig, wherein energy digestibility improves 2.96%, and dry digestibility improves 1.12%, and thick protein digestibility improves 1.18%, phosphorus digestibility improves 2.58%, and the digestibility of calcium improves 2.01%.2,1 product of filling a prescription can use by substitute antibiotics, has good application prospect.
Case study on implementation 2
Select the AA broiler chicken 20000 of 1 age in days, be divided into 2 processed group at random, each 10000 broiler chicken of each processed group.Test group chick stage feed per ton of feeding adds 1.5 kilograms (sodium butyrate content is 20%, and Sodium Benzoate content is 70%, and dextrin content is respectively 10% by formula 2.) product made, in large chicken phase feeding feed per ton add 0.9 kilogram of product made by formula 2, after 7 days, ight soil forming is reclaimed, and digesting and assimilating well of broiler chicken is described.And control group loose and watery stool is soft, in hen house, ammonia is highly seasoned, shows that broiler chicken is digested and assimilated not exclusively.
Case study on implementation 3
10 28 age in days weaning weights are the piglet of 4.24kg, and be divided into A, B two experimental group at random, A group is test group, and B group is control group, often organize each 5 weanling pigs.Test group feed per ton of feeding adds 2 kilograms (sodium butyrate content is 5%, and Sodium Benzoate content is 95%, and dextrin content is 0% by formula 3.) product made, control group fed basal diet.Draw the impact on Growth Performance of Weaning Piglets after 42 days, result is as follows:
Result shows: 3 products of filling a prescription can improve the growth performance of low weaning weight piglet, and body weight evolution improves 9.4%, and average daily gain (ADG) improves 10.66%, and feedstuff-meat ratio (FCR) improves 12.16%.
This case butyric acid and benzoic acid react with alkaline metal ions (as sodium, potassium, calcium, magnesium, zinc etc.) by a certain percentage, and spray-dried technique forms butyric acid and benzoate joint product.No matter be that butyrate directly mixes with benzoic acid, or both after the swellings are again through grease bag quilt, also or with two valence metal ions respectively in conjunction with butyric acid and benzoic acid, or other butyric acid and benzoic combination, all to realize butyric acid and benzoic synergistic effect (synergy), in this case range of rights and interests.
The foregoing is only embodiments of the invention; not thereby the scope of the claims of the present invention is limited; every utilize description of the present invention to do equivalent structure or equivalent flow process conversion; or be directly or indirectly used in other relevant technical fields, be all in like manner included in scope of patent protection of the present invention.
Claims (6)
1. butyrate and derivative thereof and benzoic acid compound prescription, is characterized in that: comprise the butyrate of weight accounting 5-50% or the benzoic acid of butanoic acid derivative and weight accounting 50-95% or benzoate.
2. butyrate as claimed in claim 1 and derivative thereof and benzoic acid compound prescription, is characterized in that: the excipient also comprising weight accounting 0-45% in described compound prescription.
3. butyrate as claimed in claim 1 and derivative thereof and benzoic acid compound prescription, is characterized in that: described butyrate is the complex of one or more in sodium butyrate, potassium butyrate, calcium butyrate, magnesium butyrate etc.
4. butyrate as claimed in claim 2 and derivative thereof and benzoic acid compound prescription, is characterized in that: described excipient is the complex of one or more in syrup, dextrin, whey powder, starch, water-soluble dietary fiber, shitosan etc.
5. butyrate and derivative thereof and benzoic acid compound product are as the application of feed addictive, it is characterized in that: in feed, add weight accounting 0.1-0.5% butyrate and benzoic acid compound product as additive, butyrate and benzoic acid compound product enter animal stomach simultaneously and are dissociated into butyric acid molecule and benzoic acid molecule, butyric acid stimulates parietal cell growth, parietal cell produces hydrochloric acid, hydrochloric acid reduces stomach inner pH value, reach the optimal pH 2.5-4.0 of benzoic acid anti-corrosive antibacterial, the anaerobic bacteria producing butyric acid is made to become dominant microflora to group, produce more endogenous organic acid as lactic acid and butyric acid, thus butyric acid is played with benzoic acid beneficial effect superpose.
6. the preparation method of butyrate and derivative and benzoic acid compound product, is characterized in that: in retort, add water, under agitation adds hydroxide, stirs fully to dissolving, then adds benzoic acid gradually, stirring reaction, dissolving; Continue under agitation to add butyric acid, by adding control temperature not higher than 105 DEG C, generate the mixed liquor of butyrate and benzoate, reaction terminates, and cooling reactant liquor is to temperature 60 C ~ 90 DEG C; Commissioning pH value again, adds appropriate butyric acid or basic salt, commissioning reacting liquid pH value to 8 ~ 10; Then, under agitation in the reactant liquor of retort, add dextrin, stirring and dissolving or in suspension; Continue cooling reactant liquor to temperature 25 DEG C ~ 50 DEG C; Then EAT 150 DEG C ~ 260 DEG C, under leaving air temp 65 DEG C ~ 160 DEG C conditions, carry out spraying dry, finally, through the dry powder that cyclone separator or vibrated fluidized bed are collected, obtain butyrate and benzoic acid (salt) microspheric particle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510559576.6A CN105076726A (en) | 2015-09-06 | 2015-09-06 | Butyrate, butyrate derivative and benzoic acid compound formula, preparation method and application of butyrate, butyrate derivative and benzoic acid compound product as feed additive |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510559576.6A CN105076726A (en) | 2015-09-06 | 2015-09-06 | Butyrate, butyrate derivative and benzoic acid compound formula, preparation method and application of butyrate, butyrate derivative and benzoic acid compound product as feed additive |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105076726A true CN105076726A (en) | 2015-11-25 |
Family
ID=54558785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510559576.6A Pending CN105076726A (en) | 2015-09-06 | 2015-09-06 | Butyrate, butyrate derivative and benzoic acid compound formula, preparation method and application of butyrate, butyrate derivative and benzoic acid compound product as feed additive |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105076726A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105614078A (en) * | 2016-02-02 | 2016-06-01 | 广州自远生物科技有限公司 | Composition for adjusting animal body electrolyte balance and acid-base balance and its application |
| CN105661046A (en) * | 2016-02-23 | 2016-06-15 | 广州英赛特生物技术有限公司 | Application of calcium benzoate to preparing of animal feed additive |
| CN105708826A (en) * | 2016-02-02 | 2016-06-29 | 广州自远生物科技有限公司 | Composition for regulating electrolyte balance and acid-base balance of animal organisms and application thereof |
| CN105724779A (en) * | 2016-02-23 | 2016-07-06 | 广州英赛特生物技术有限公司 | Compound feeding composition and application of compound feeding composition in preparation of animal feed additive |
| CN105724781A (en) * | 2016-02-23 | 2016-07-06 | 广州英赛特生物技术有限公司 | Feed composition and application thereof to preparation of animal feed additive |
| CN107927348A (en) * | 2017-11-10 | 2018-04-20 | 杭州康德权饲料有限公司 | It is a kind of while produce sodium butyrate original powder and the system and production technology of butyric acid salt particle |
| EP3363295A4 (en) * | 2015-10-15 | 2019-04-17 | Singao (Xiamen) Agribusiness Development Co., Ltd. | Compound formula of butyrate and derivatives thereof and benzoic acid, and preparation method therefor and application thereof as feed additive |
| CN114586888A (en) * | 2022-03-24 | 2022-06-07 | 中农汇科生物科技有限公司 | Mixed feed additive capable of preventing and treating escherichia coli of chickens and preparation method thereof |
| WO2022199678A1 (en) * | 2021-03-25 | 2022-09-29 | 新奥（厦门）农牧发展有限公司 | Novel sodium butyrate particle and preparation method therefor |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1225553A (en) * | 1996-07-19 | 1999-08-11 | 凯米拉化学有限公司 | Antimicrobial composition, method for prepn. of same |
| CN101331915A (en) * | 2007-06-29 | 2008-12-31 | 帝斯曼知识产权资产管理有限公司 | Animal feed composition |
| CN101647516A (en) * | 2009-06-17 | 2010-02-17 | 新奥（厦门）农牧发展有限公司 | Compound of butyrate or glycerol monobutyralte and dietary fiber and preparation method thereof and application of compound in feed additive |
| CN102450519A (en) * | 2010-12-07 | 2012-05-16 | 山东六和集团有限公司 | Creep compound feed for piglets and preparation method thereof |
-
2015
- 2015-09-06 CN CN201510559576.6A patent/CN105076726A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1225553A (en) * | 1996-07-19 | 1999-08-11 | 凯米拉化学有限公司 | Antimicrobial composition, method for prepn. of same |
| CN101331915A (en) * | 2007-06-29 | 2008-12-31 | 帝斯曼知识产权资产管理有限公司 | Animal feed composition |
| CN101647516A (en) * | 2009-06-17 | 2010-02-17 | 新奥（厦门）农牧发展有限公司 | Compound of butyrate or glycerol monobutyralte and dietary fiber and preparation method thereof and application of compound in feed additive |
| CN102450519A (en) * | 2010-12-07 | 2012-05-16 | 山东六和集团有限公司 | Creep compound feed for piglets and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 中国农业科学院饲料研究所: "《中国饲料原料采购指南（第2版）》", 30 November 2007, 中国农业大学出版社 * |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3363295A4 (en) * | 2015-10-15 | 2019-04-17 | Singao (Xiamen) Agribusiness Development Co., Ltd. | Compound formula of butyrate and derivatives thereof and benzoic acid, and preparation method therefor and application thereof as feed additive |
| CN105614078A (en) * | 2016-02-02 | 2016-06-01 | 广州自远生物科技有限公司 | Composition for adjusting animal body electrolyte balance and acid-base balance and its application |
| CN105708826A (en) * | 2016-02-02 | 2016-06-29 | 广州自远生物科技有限公司 | Composition for regulating electrolyte balance and acid-base balance of animal organisms and application thereof |
| CN105661046A (en) * | 2016-02-23 | 2016-06-15 | 广州英赛特生物技术有限公司 | Application of calcium benzoate to preparing of animal feed additive |
| CN105724779A (en) * | 2016-02-23 | 2016-07-06 | 广州英赛特生物技术有限公司 | Compound feeding composition and application of compound feeding composition in preparation of animal feed additive |
| CN105724781A (en) * | 2016-02-23 | 2016-07-06 | 广州英赛特生物技术有限公司 | Feed composition and application thereof to preparation of animal feed additive |
| WO2017143665A1 (en) * | 2016-02-23 | 2017-08-31 | 广州英赛特生物技术有限公司 | Compound feeding composition and application thereof in preparation of animal feed additive |
| CN105661046B (en) * | 2016-02-23 | 2020-12-18 | 广州英赛特生物技术有限公司 | Application of calcium benzoate in preparation of animal feed additive |
| CN107927348A (en) * | 2017-11-10 | 2018-04-20 | 杭州康德权饲料有限公司 | It is a kind of while produce sodium butyrate original powder and the system and production technology of butyric acid salt particle |
| WO2022199678A1 (en) * | 2021-03-25 | 2022-09-29 | 新奥（厦门）农牧发展有限公司 | Novel sodium butyrate particle and preparation method therefor |
| CN114586888A (en) * | 2022-03-24 | 2022-06-07 | 中农汇科生物科技有限公司 | Mixed feed additive capable of preventing and treating escherichia coli of chickens and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105076726A (en) | Butyrate, butyrate derivative and benzoic acid compound formula, preparation method and application of butyrate, butyrate derivative and benzoic acid compound product as feed additive | |
| CN101715898B (en) | Acidating agent for newborn piglet feed and preparation method thereof | |
| CN102370102B (en) | Sucking pig compound feed and preparation method thereof | |
| CN103349186B (en) | Weaned piglet feed additive and preparation method thereof | |
| CN101756069B (en) | High-efficiency and environment-friendly feed additive for pigs and preparation method thereof | |
| CN102870990B (en) | Sow fermented feed and production method thereof | |
| CN106983032A (en) | A kind of microorganism compound feed additive and preparation method thereof | |
| CN102178092A (en) | Method for preparing high-moisture fermented granular feed for poultry | |
| CN102178093A (en) | Method for preparing high-moisture fermented granulated feed for pigs | |
| CN103689259A (en) | Suckling pig feed and preparation method thereof | |
| CN111345402A (en) | Functional additive and preparation method and application thereof | |
| CN103621826A (en) | Low-carbon environment-friendly conservation-stage piglet feed | |
| CN105614020A (en) | Micro-ecological alfalfa feed additive for livestock and preparation method thereof | |
| CN104172187A (en) | Preparation method of probiotics fermented flavor powder | |
| CN105341379A (en) | Complete mixed granular feed for breeding ewes and preparation method of complete mixed granular feed | |
| CN106689672A (en) | Synbiotics composition, synbiotics preparation, preparation method and application thereof | |
| CN107373132A (en) | Enzyme preparation live pig mixed feed | |
| CN101297679A (en) | Feedstuff additive for improving immunity of livestock and poultry and preparation thereof | |
| CN112715767A (en) | Feed additive for improving intestinal function of early weaned piglets and application thereof | |
| CN105285399A (en) | Liquid state composite microecological preparation for pigling and preparation method thereof | |
| Galina et al. | Fattening Pelibuey lambs with sugar cane tops and corn complemented with or without slow intake urea supplement | |
| CN104397408A (en) | Antibiotic-free concentrated feed for laying chicks and preparation method of antibiotic-free concentrated feed | |
| CN104232547A (en) | Microbial flora additive used for sheep feed, and preparation method thereof | |
| EP4252541A1 (en) | Method for improving productivity in livestock and/or poultry and method for improving intestinal flora in livestock and/or poultry | |
| CN104957373A (en) | Method for reducing heavy metal emission in livestock and poultry manure |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |