CN102302088A - Coated cysteamine hydrochloride and preparation method thereof - Google Patents
Coated cysteamine hydrochloride and preparation method thereof Download PDFInfo
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- CN102302088A CN102302088A CN201110155969A CN201110155969A CN102302088A CN 102302088 A CN102302088 A CN 102302088A CN 201110155969 A CN201110155969 A CN 201110155969A CN 201110155969 A CN201110155969 A CN 201110155969A CN 102302088 A CN102302088 A CN 102302088A
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- mercaptamine
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- cysteamine hydrochloride
- stearic acid
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Abstract
The invention relates to a coated cysteamine hydrochloride in the technical field of the coating of the cysteamine hydrochloride. The coated cysteamine hydrochloride comprises the following components in parts by weight: 29-35 parts of cysteamine hydrochloride, 13-17 parts of stearic acid, 12-14 parts of cellulose aqueous solution with methylcellulose content of 5 wt%, 4.5-5.5 parts of citric acid and 32-38 parts of white carbon black. The preparation method comprises the following steps of: weighing raw materials; adding the stearic acid, the cellulose aqueous solution, the cysteamine hydrochloride and the citric acid to a colloid mill in sequence to be ground into milk-white liquid; adding the liquid to the white carbon black in a stirring state so as to obtain white bulk granular powder; and screening the powder by using a screen of 0.3 mm. The coated cysteamine hydrochloride and the preparation method thereof, provided by the invention, have the advantages of simple process, cheap raw material, low production cost, high finished product rate and no generation of substances like waste gas, wastes and the like; therefore, no environment pollution is caused, the stability problem of the cysteamine hydrochloride is solved, and no great irritation can be caused to the stomach while the coated cysteamine hydrochloride is taken for a long time.
Description
Technical field
The present invention relates to the coating technique field of Mercaptamine, particularly a kind of Mercaptamine that encapsulates also relates to the preparation method that this encapsulates Mercaptamine.
Background technology
Mercaptamine is the additive that the permission of stipulating in the file that issues of the national Ministry of Agriculture (2006) is used in animal and fowl fodder.
Cysteamine; Claiming β-TGA again, be equivalent to the decarboxylate of NAC, is the part of coacetylase molecule; It is the bioactivator in the animal body; Having the important physical effect in vivo. big quantity research shows that external source is added cysteamine can exhaust that body somatostatin (SS) .SS is a kind of 14 peptides (Brazeau, 1973) that separate from the sheep hypothalamus at first; Being distributed widely in the interior system of nervous centralis, adrenal medella, pancreas and the alimentary canal of various animals. growth hormone release inhibiting hormone is except the secretion of regulation and control somatotropin; Also suppress to organize various physiological processes such as endocrine and exocrine, cytothesis, nutrient absorption, SS has immunoreactivity and receptor acting. since (1981) such as Szabo find that cysteamine can be exhausted growth hormone release inhibiting hormone, and the dopamine-inhibitor that cysteamine (CS) is still stronger; Cause accumulating of dopamine, and dopamine promotes the synthetic and secretion of GH strongly at hypothalamus.Contained active component can play nutrient absorption and the conversion that improves body, improves growth of animals or poultry speed, reduces body lipidosis, and the degraded of CKIs matter promotes protein synthetic, promotes to increase, and improves carcass quality, improves physiological regulating control effects such as lean meat percentage.Its research report is more and more. and cysteamine is a white crystals, and bad smell is arranged, and is soluble in water and pure, react acid; 97～98.5 ℃ of fusing points, but chemical synthesis also can extract from the animal natural hair. and extremely unstable in air; Be prone to oxidation, be made generally in hydrochloride, keep in Dark Place.
Big quantity research shows that cysteamine adds the level of growth that can improve herding in the feed; Because its unique chemical structure; Make this product as easy as rolling off a log oxidative deformation in natural environment; As be exposed in the air 0.5 hour and just lose effect, so do not process, can not utilize aborning at all.
The product that encapsulates relatively more commonly used at present mainly contains down several kinds: common premixed type, and this product has very strong stink, and oxidized easily, practical application has no value, uses less; Normal packet through encapsulating, has been solved the cysteamine stability problem by type, but cannot heavy dose of use, if use 800-1000ppm, a period of time, gastric ulcer can appear in pig, has a strong impact on searching for food and digesting of pig, causes pig to become thin, even dead; Micro-capsule encapsulates type and enteric encapsulates type because of its higher price, can increase aquaculture cost, is not widely used always.
Publication number is the slow-release pill that the Chinese invention patent application of CN101653426A discloses a kind of high-stability type cysteamine hydrochloride; Form by Mercaptamine, silica and as dressing wall material macromolecular material; Earlier liquid Mercaptamine is adsorbed into the Mercaptamine particle with the silica piller; With dressing wall material above-mentioned Mercaptamine particle is encapsulated then, shape film forming chamber control structure, drying obtains slow-release pill.Preparation technology's more complicated of this slow-release pill, and need be through super-dry, Mercaptamine needs long term exposure in air in the preparation process, is easy to oxidation takes place and loses efficacy.
Summary of the invention
Encapsulate the cost height in order to solve above Mercaptamine, the process that encapsulates is complicated is prone to oxidized, normal packet by the problem of long-term safety in utilization; The invention provides and encapsulate that cost is low, the process that encapsulates is simple, reduce Mercaptamine open-assembly time, the long-term a kind of Mercaptamine that encapsulates that has no side effect that uses; It is encapsulated with method chemistry through physics; Completely cut off it as far as possible in the contact of air, slow down the speed of its oxidation greatly, so that use in breeding production.
The present invention also provides the above-mentioned preparation method who encapsulates Mercaptamine.
The present invention realizes through following measure:
A kind of Mercaptamine that encapsulates, form by the component of following weight portion:
Mercaptamine 29-35 part, stearic acid 13-17 part, methylcellulose content is cellulose aqueous solution 12-14 part of 5wt%, citric acid 4.5-5.5 part, white carbon 32-38 part.
The described Mercaptamine that encapsulates, form by the component of following weight portion:
32 parts of Mercaptamines, 15 parts of stearic acid, methylcellulose content are 13 parts of the cellulose aqueous solutions of 5wt%, 5 parts of citric acids, 35 parts of white carbons.
Preferred stearic acid makes through the unrighted acid hydrogenation.
2wt% aqueous solution viscosity is 5000mPas during 20 ℃ of preferable methyl celluloses.
A kind of described preparation method who encapsulates Mercaptamine may further comprise the steps:
(1) 48 hours in advance, methylcellulose fully is dissolved in the ratio of 5wt% in 60-70 ℃ the water and forms cellulose aqueous solution, in advance block Mercaptamine is pulverized, the stearic acid heating and melting is become liquid;
(2) take by weighing each raw material by formula ratio, and add in the colloid mill by the order of stearic acid-cellulose aqueous solution-Mercaptamine-citric acid and to grind, 2800 rev/mins of grinding rates, time 15-20 minute are mixed into milky white liquid;
(3) milky white liquid is added in the white carbon under the stirring, stir, obtain loose shape white powder;
(4) white powder is crossed the sieve of 0.3mm, promptly obtained encapsulating Mercaptamine.
The present invention makes Mercaptamine fully mix with stearic acid through the grinding technics of colloid mill, utilizes stearic water proof, gas barrier properties, reduces the chance that it contacts with empty G&W; And to mixture a sour environment is provided through adding citric acid; Acidity is increased, delay the oxidation of Mercaptamine, cellulosic main effect is to encapsulate with bonding; It is figuration that white carbon mainly acts on; Through such processing, can slow down the speed of Mercaptamine oxidation greatly, reach it and in feed, directly add the purpose of using.
Preparation of the present invention encapsulates the method for Mercaptamine; Use stearic acid, cellulose aqueous solution, Mercaptamine and the citric acid of colloid mill liquid towards to grind; Can reduce Mercaptamine in the preparation process with the contacting of air, can farthest keep effective dose.That produces encapsulates the Mercaptamine finished product, because the chance of isolated active ingredient and air and contact with moisture reduces its oxidation rate greatly, plays the effect that encapsulates.
Raw material stearic acid, the citric acid that the present invention uses makes that to encapsulate Mercaptamine more stable to acid, so seldom digested under one's belt, mainly digested in intestines portion, so alleviated the stimulation of Mercaptamine to stomach, guaranteed the security of long-term use; White carbon can be discharged through metabolism, can not produce negative effect, edible safety to animal.
Beneficial effect of the present invention:
(1) technology is simple, and raw material is cheap, and low production cost, finished product are adapted in the aquaculture feed adding and use, and to promoting the growth of pig, improves lean meat percentage, and improving aspect such as yellowish pink has good effect;
(2) this process yield is high, does not have defect ware to produce basically, and productivity ratio is near a hundred per cent, and production process does not produce materials such as waste gas, refuse, therefore also can not cause environmental pollution;
(3) solved the stability problem of Mercaptamine, and ediblely also can not produce very big stimulation for a long time stomach.
The specific embodiment
For a better understanding of the present invention, further specify below in conjunction with specific embodiment.
Embodiment 1:
A kind of Mercaptamine that encapsulates, form by the component of following weight portion:
35 parts of Mercaptamines, 13 parts of stearic acid, methylcellulose content are 12 parts of the cellulose aqueous solutions of 5wt%, 4.5 parts of citric acids, 32 parts of white carbons.The Mercaptamine initial content is 51.7%.
The preparation method:
The first step: produce to prepare: 1,48 hours in advance, cellulose is dissolved in the ratio of 5wt% in 60-70 ℃ the warm water, and often stirs, make it fully dissolve the formation cellulose aqueous solution; 2, become liquid condition for use the stearic acid heating and melting; 3, block Mercaptamine is broken into appropriate fritter;
Second step: grinding technics: the ratio by in the prescription takes by weighing various raw materials; And by stearic acid--cellulose aqueous solution-Mercaptamine---the order of citric acid successively adds in the colloid mill grinds; 2800 rev/mins of grinding rates, time 15-20 minute let the abundant ground and mixed of various compositions become milky white liquid to get final product;
The 3rd step: formative stage: ground milky white liquid is slowly injected the spiral mixer that white carbon is housed and is moving always, mixture and white carbon are stirred, become loose shape white powder to get final product;
The 4th step: the packing of sieving: with the white powder finished product that mixes; Cross the sieve of 0.3mm; Remove out the material that bulk does not stir; Can be and encapsulate the Mercaptamine finished product through the dispersiveness of sieve, mobile good white finely ground particle substance, press different size at last and get final product with plastic bag packaging.
Embodiment 2:
A kind of Mercaptamine that encapsulates, form by the component of following weight portion:
29 parts of Mercaptamines, 17 parts of stearic acid, methylcellulose content are 14 parts of the cellulose aqueous solutions of 5wt%, 5.5 parts of citric acids, 38 parts of white carbons.The Mercaptamine initial content is 28%.
The preparation method is with embodiment 1.
Embodiment 3:
A kind of Mercaptamine that encapsulates, form by the component of following weight portion:
32 parts of Mercaptamines, 15 parts of stearic acid, methylcellulose content are 13 parts of the cellulose aqueous solutions of 5wt%, 5 parts of citric acids, 35 parts of white carbons.The Mercaptamine initial content is 32%.
The preparation method is with embodiment 1.
Embodiment 4:
A kind of Mercaptamine that encapsulates, form by the component of following weight portion:
32 parts of Mercaptamines, 15 parts of the stearic acid that makes through the unrighted acid hydrogenation technique, methylcellulose content are 13 parts of the cellulose aqueous solutions of 5wt%, 5 parts of citric acids, 35 parts of white carbons.The Mercaptamine initial content is 32%.
Wherein unrighted acid hydrogenation technique system stearic acid has been prior art, and a lot of relevant reports are arranged, and therefore in order to save space, just is not described in detail in the present invention.
Used methylcellulose 2wt% aqueous solution viscosity in the time of 20 ℃ is 5000mPas.
The preparation method who encapsulates Mercaptamine is with embodiment 1.
The compliance test result experiment
Stability test
With encapsulate Mercaptamine and the publication number of embodiment 1 and 3 preparations is that the disclosed Mercaptamine slow-release pill of Chinese invention patent application of CN101653426A carries out stability test.The Mercaptamine initial content is high more; Coated degree is just low more; So oxidized possibility and speed are just big more; Because the Mercaptamine initial content is 28% among the embodiment 2, oxidized speed is very slow, so only selected the Mercaptamine that encapsulates of embodiment 1 and 3 preparations to test.
Method of testing is following:
Specimen is respectively charged in the glass dish; Spread out into the identical thin layer of thickness in the bottom; Under normal temperature condition, place naturally; The content of Mercaptamine in the specimen respectively at one day, ten days, 30 days, two months, five months, eight months, 12 months, 18 months, 24 months, the result sees the following form 1.
Mercaptamine contains scale in the sample that table 1 records different standing times
Can know by table 1; The stability that encapsulates Mercaptamine of embodiment of the invention preparation is good than the Mercaptamine slow-release pill; Wherein the stability of embodiment 3 is good than embodiment 1; And the stability of embodiment 4 is more much better than embodiment 3, so the present invention has solved the problem of Mercaptamine poor stability really.
Animal experiment
Choose 200 of two-way cross meat piglets, public mother half and half, Random assignment to test group and control group, 100 every group, to raise, experimental group and control group begin body weight and are respectively 20.1 ± 0.21 kilograms, 20.0 ± 0.19 kilograms, and the time is 135 days.Test group is added total amount in feed be that the present invention of 100mg encapsulates Mercaptamine, do not add in the control group feed, duration of test only to the relevant vaccine of pig injection with control disease, record feed intake and body weight.
Control group, every pig average weight of test group are respectively 105.4 ± 1.58 kilograms, 116.15 ± 1.86 kilograms during off-test, and every average feed intake of pig is respectively 332.01 kilograms, 335.67 kilograms.The analytic record data, test group on average improves 10.2 ± 0.24% (P < 0.01%) than control group daily gain, and feedstuff-meat ratio reduces by 8.4% (P < 0.5%).
The result shows; The meat piglet is used the effect that Mercaptamine has tangible promotion growth that encapsulates of the present invention; And help to improve the feed feedstuff-meat ratio, and the for a long time edible Mercaptamine that encapsulates of the present invention of test group pig, feed intake there is not passive influence; Also do not have the situation appearance that pig suffers from gastrointestinal disease to occur, the visible long-term edible safety of Mercaptamine that encapsulates of the present invention is stronger.
Aspect cost; The Mercaptamine that encapsulates of the present invention is compared with the enteric type of encapsulating with the micro-capsule type that encapsulates and is had great advantage, and manufacture craft is simple to operation, does not need special-purpose main equipment support; So aspect cost performance, have very big advantage, have very much the value of applying.
Claims (5)
1. one kind encapsulates Mercaptamine, it is characterized in that being made up of the component of following weight portion:
Mercaptamine 29-35 part, stearic acid 13-17 part, methylcellulose content is cellulose aqueous solution 12-14 part of 5wt%, citric acid 4.5-5.5 part, white carbon 32-38 part.
2. the Mercaptamine that encapsulates according to claim 1 is characterized in that being made up of the component of following weight portion:
32 parts of Mercaptamines, 15 parts of stearic acid, methylcellulose content are 13 parts of the cellulose aqueous solutions of 5wt%, 5 parts of citric acids, 35 parts of white carbons.
3. the Mercaptamine that encapsulates according to claim 1 is characterized in that said stearic acid makes through the unrighted acid hydrogenation.
4. the Mercaptamine that encapsulates according to claim 1,2wt% aqueous solution viscosity is 5000mPas when it is characterized in that 20 ℃ of said methylcellulose.
5. each described preparation method who encapsulates Mercaptamine among the claim 1-4 is characterized in that may further comprise the steps:
(1) 48 hours in advance, methylcellulose fully is dissolved in the ratio of 5wt% in 60-70 ℃ the water and forms cellulose aqueous solution, in advance block Mercaptamine is pulverized, the stearic acid heating and melting is become liquid;
(2) take by weighing each raw material by formula ratio, and add in the colloid mill by the order of stearic acid-cellulose aqueous solution-Mercaptamine-citric acid and to grind, 2800 rev/mins of grinding rates, time 15-20 minute are mixed into milky white liquid;
(3) milky white liquid is added in the white carbon under the stirring, stir, obtain loose shape white powder;
(4) white powder is crossed the sieve of 0.3mm, promptly obtained encapsulating Mercaptamine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101559692A CN102302088B (en) | 2011-06-11 | 2011-06-11 | Coated cysteamine hydrochloride and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101559692A CN102302088B (en) | 2011-06-11 | 2011-06-11 | Coated cysteamine hydrochloride and preparation method thereof |
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| CN102302088A true CN102302088A (en) | 2012-01-04 |
| CN102302088B CN102302088B (en) | 2012-12-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011101559692A Expired - Fee Related CN102302088B (en) | 2011-06-11 | 2011-06-11 | Coated cysteamine hydrochloride and preparation method thereof |
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| CN104000027A (en) * | 2013-05-08 | 2014-08-27 | 济南海华生物科技有限公司 | Method for preparing cysteamine hydrochloride preparation |
| CN111513192A (en) * | 2020-05-19 | 2020-08-11 | 北京中联华康科技有限公司 | Esterified cysteamine hydrochloride stable powder and preparation method and application thereof |
| CN115636977A (en) * | 2022-12-02 | 2023-01-24 | 中国科学院长春应用化学研究所 | Recyclable solvent for dissolving cellulose and recycling method thereof |
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| CN101715898A (en) * | 2009-11-27 | 2010-06-02 | 济南天天香有限公司 | Acidating agent for newborn piglet feed and preparation method thereof |
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| CN104000027A (en) * | 2013-05-08 | 2014-08-27 | 济南海华生物科技有限公司 | Method for preparing cysteamine hydrochloride preparation |
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| CN104026350B (en) * | 2013-05-08 | 2016-05-25 | 济南海华生物科技有限公司 | Mercaptamine preparation and application thereof |
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| CN111513192A (en) * | 2020-05-19 | 2020-08-11 | 北京中联华康科技有限公司 | Esterified cysteamine hydrochloride stable powder and preparation method and application thereof |
| CN115636977A (en) * | 2022-12-02 | 2023-01-24 | 中国科学院长春应用化学研究所 | Recyclable solvent for dissolving cellulose and recycling method thereof |
| CN115636977B (en) * | 2022-12-02 | 2023-10-13 | 中国科学院长春应用化学研究所 | Recoverable solvent for dissolving cellulose and recovery method thereof |
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| CN102302088B (en) | 2012-12-26 |
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