CN104000027A - Method for preparing cysteamine hydrochloride preparation - Google Patents
Method for preparing cysteamine hydrochloride preparation Download PDFInfo
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- CN104000027A CN104000027A CN201410269573.4A CN201410269573A CN104000027A CN 104000027 A CN104000027 A CN 104000027A CN 201410269573 A CN201410269573 A CN 201410269573A CN 104000027 A CN104000027 A CN 104000027A
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Abstract
A method for preparing a cysteamine hydrochloride preparation is characterized by including the following steps of firstly, processing cysteamine hydrochloride in a plastic container through the boiling water bath for 15 hours to 16 hours till the cysteamine hydrochloride is completely melted; secondly, slowly adding 55 parts of molten cysteamine hydrochloride to white carbon block with the same weight in the stirring state and continuing to conduct stirring for 20 minutes to 30 minutes till the mixture is in an even powdery state; thirdly, adding 6 parts to 14 parts of dihydropyridine and 10 parts to 20 parts of L-lactic acid to obtained even powder, and fully and evenly mixing the mixture till the mixture is in an even powdery shape; fourthly, placing the even powder obtained in the third step in a sealed plastic thin film bag, and standing for 5 days to 12 days; fifthly, smashing the product obtained in the fourth step in an oscillating granulator, and enabling the smashed product to pass through a sieve with the number of meshes ranging from 16 to 20 to obtain the anti-oxidant and high temperature resistant cysteamine hydrochloride preparation. The obtained cysteamine hydrochloride preparation and fodder are mixed according to the ratio of 0.5%, the mixture is directly fed to beasts and birds, and therefore the growth rate of beasts and birds is effectively increased, the carcass quality of beasts and birds is improved, the yield is increased, and cost is reduced.
Description
The application is to be on May 8th, 2013 applying date, and application number is 2013101672872, and name is called the dividing an application of Chinese invention patent application of anti-oxidant high temperature resistant Mercaptamine preparation preparation and application thereof.
Technical field
The present invention relates to the preparation of anti-oxidant high temperature resistant Mercaptamine preparation and the application on livestock and poultry cultivation thereof; be specifically related to a kind ofly take Mercaptamine as raw material, by adding anti-oxidant protective agent and process control, obtain the preparation method of the Mercaptamine preparation with high antioxygenic property and promoting growth of animals or poultry and improving the application in its carcass quality.
Background technology
Cysteamine is the metabolite of NAC in animal body, is the important composition composition of coacetylase.Studies have shown that both at home and abroad, cysteamine can, by exhaustion animal body somatostatin (SS), promote the secretion of somatotropin and strengthen gastral physiological function, and reach the effect that improves growth of animal performance and carcass quality indirectly.It is due to the inhibitory action of hormone to Fatty synthesis key enzyme that cysteamine reduces fat, causes Fatty synthesis and esterified minimizing, the result that fat deposition lowers.
L-lactic acid is natural metabolite in animal body, and it is added in feed as acidulant, can not leave in animal body harmful substance.In animal feed, add L-lactic acid and can reduce stomach inner pH value, make acid-base balance in animal body, improve digestive enzyme activity, reduce the pH value of feed and alimentary canal front portion.In addition, L-lactic acid can increase beneficial bacterium quantity in alimentary canal, effectively suppresses harmful microbe necessary condition, also can improve growth of animal performance and efficiency of feed utilization, reaches the object that strengthens body resistance against diseases.
Dihydropyridine is a kind of novel multifunctional additive with natural antioxidant effect, can suppress the peroxidating process of lipoid substance, forms liver protective layer; There is grease and vitamin V A, the not oxidized antioxidation of carrotene in protection feed.Meanwhile, can also change some hormonal readiness in serum, promote animal growth and development, improve the milking capacity of reproductive performance and dam, and strengthen immunologic function, and its metabolism completely, almost noresidue.
Cysteamine is white crystals, extremely unstable, oxidizable in air, is made generally in hydrochloride, keeps in Dark Place.Due to its easy oxidized characteristic, cause it must suitably process in process of production, otherwise just can lose efficacy because of oxidized.Publication number is the slow-release pill that the Chinese invention patent application of CN101653426A discloses a kind of high-stability type cysteamine hydrochloride, by Mercaptamine, silica and form as dressing wall material macromolecular material.Preparation technology's more complicated of this slow-release pill, and capsulating material is macromolecular material, is easy to cause active ingredient Mercaptamine to discharge in enteron aisle not enough, causes wastage of material.Publication number is that the Chinese invention patent of CN 102302088 A discloses a kind of coated Mercaptamine and preparation method thereof, by the order of stearic acid-cellulose aqueous solution-Mercaptamine-citric acid, adds and in colloid mill, grinds to form milky white liquid; Add in the white carbon under stirring, obtain loose shape white powder.Although this technique is stipulated the order of addition of capsulating material; but because stearic acid, cellulose aqueous solution, Mercaptamine and four kinds of liquid of citric acid are finally to mix under the effect of colloid mill; so cannot guarantee that all Mercaptamines can be adequately protected; be not subject to air oxidation, therefore can cause product stability and effect to decline.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art (as capsulating material hard degradation and absorption, causes Mercaptamine to discharge not enough, coating is insufficient, cause the Mercaptamine oxidized etc.) and provide a kind of and there is antioxygenic property by utilization, easily by animal, digested and assimilated and there is growth promotion and on Mercaptamine surface, form protective layer with regulating the material of gastrointestinal function, to reach simplification production technology, reduce production costs, protection Mercaptamine, strengthen clinical result of use, further expand the anti-oxidant high temperature resistant Mercaptamine formulation preparation method of use, anti-oxidant protective agent of the present invention is easy to be digested and assimilated by animal, guarantee on the one hand abundant release and the absorption of active ingredient Mercaptamine, capsulating material can be used as active ingredient promotion growth of animal simultaneously on the other hand, reduce diarrhea rate, reduced production cost.
Another object of the present invention is to provide a kind of anti-oxidant high temperature resistant Mercaptamine preparation in its feeding field with important application.
The object of invention is achieved in that a kind of anti-oxidant high temperature resistant Mercaptamine preparation, it is characterized in that it is comprised of the component of following weight portion: Mercaptamine 50-55 part, Pfansteihl 10-20 part, dihydropyridine 6-14 part, white carbon 11-39 part.
Concrete technology of the present invention is as follows: a kind of preparation method of anti-oxidant high temperature resistant Mercaptamine preparation, is characterized in that it comprises the steps:
(1) Mercaptamine boiling water bath in plastic containers is processed 15-16 hour until melt completely;
(2) melting Mercaptamine step (1) being obtained slowly adds in the white carbon under stirring, continues to stir 20-30 minute, until be homogeneous powder powder;
(3) in the uniform powder obtaining toward step (2), add 6-14 part dihydropyridine and 10-20 part Pfansteihl, fully mix, to being homogeneous powder powder;
(4) uniform powder standing 5-12 days in sealed plastic film bag will be obtained in step (3);
(5) product obtaining in step (4) pulverized and crossed 16-20 mesh sieve in oscillating granulator, obtaining anti-oxidant high temperature resistant Mercaptamine preparation.
The concrete feature of this programme also has, and first Mercaptamine evenly adsorbs with white carbon, and dihydropyridine and Pfansteihl are uniformly distributed in Mercaptamine skin.
The even pulverulent mixture that step (3) obtains standing 5-12 days in airtight polybag, is exhausted bag internal oxygen gas and is formed diaphragm on Mercaptamine surface by slow chemical reaction.
An application for anti-oxidant high temperature resistant Mercaptamine preparation, is characterized in that anti-oxidant high temperature resistant Mercaptamine preparation is used as feed addictive on livestock and poultry cultivation.
Anti-oxidant high temperature resistant Mercaptamine preparation mixes with feed with 0.5% ratio, Direct-fed livestock and poultry.
The present invention has following good effect: 1, good as dihydropyridine and the Pfansteihl animal absorbability of anti-oxidation protection layer; not oxidized and improve product heat-resisting ability except protecting Mercaptamine; dihydropyridine can promote growth of animal; Pfansteihl can improve animal gastrointestinal tract; reduce diarrhea rate; compare with the common macromolecule capsulating material that is difficult to be absorbed by animal; not only can protect Mercaptamine not oxidized; and can growth promotion and reduce diarrhea rate, reduced production cost.
2, in preparation process, pass through the stationary phase of 5-12 days; this process anti-oxidation protection material is by consuming the oxygen in environment; cause on the one hand oxygen-free environment protection Mercaptamine; course of reaction forms even diaphragm by chemical reaction at product surface on the other hand, improves the anti-oxidant heat-resisting ability of product.
3, take dihydropyridine and easily degrade as the diaphragm that dominant shape becomes with Pfansteihl, be convenient to Mercaptamine and discharge fast and absorbed by body, avoid being excreted because of discharging, and then the utilization rate of raising active ingredient.
4, anti-oxidant high temperature resistant technique makes the product not only can be not by dioxygen oxidation in air, improved the tolerance of product to high temperature simultaneously, therefore said preparation can tolerate the high temperature of feed high temperature granulating process and extruding etc., can directly make an addition in pellet and guarantee that the activity of Mercaptamine is unaffected.
In addition; the anti-oxidant protective agent adopting due to the present invention is that dihydropyridine and Pfansteihl have growth promotion, anti-oxidant and improve the effect of gastrointestinal function; compare with other similar Mercaptamine patent of invention; embodiment product, except having Mercaptamine growth promotion, improving the direct effect of lean meat percentage, shows the effect of obvious reduction Incidence of Diarrhea in growing and fattening pigs and feeding of broiler embodiment.Illustrate that this inventive method not only can improve the anti-oxidant and heat-resistant stable of Mercaptamine, invention product has the effect that promotes growth of animals or poultry, improves lean meat percentage and reduction Incidence of Diarrhea simultaneously.The present invention is by adopting protective layer material and the anti-oxidant high temperature resistant production technology easily absorbing; guaranteed the activity of Mercaptamine; improved the absorptivity of body to Mercaptamine; improved product effect; reduced production cost; strengthened its effect on livestock and poultry cultivation, made product there is stronger competitiveness.
Accompanying drawing explanation
Fig. 1 is process chart of the present invention.
The specific embodiment
Embodiment 1
1, Mercaptamine boiling water bath in plastic containers is processed 15 hours until melt completely;
2,55 parts of melting Mercaptamines are slowly added in 29 deal white carbons under stirring, continue to stir 30 minutes, until be homogeneous powder powder;
3, in Mercaptamine and white carbon uniform powder, add 6 parts of dihydropyridines and 10 parts of Pfansteihls, fully mix, to being homogeneous powder powder;
4, by the uniform powder obtaining in sealed plastic film bag standing 7 days;
5, the stable prod of reaction end and caking pulverized and crossed 16 mesh sieves in oscillating granulator, obtaining anti-oxidant high temperature resistant Mercaptamine preparation.Sampling inspection cysteine hydrochloride content 52.9%, detect qualified after, packing warehouse-in.
Embodiment 2
1, Mercaptamine boiling water bath in plastic containers is processed 16 hours until melt completely;
2,55 parts of melting Mercaptamines slowly are added to 11 under stirring? in deal white carbon, continue to stir 30 minutes, until be homogeneous powder powder;
3, in Mercaptamine and white carbon uniform powder, add 14 parts of dihydropyridines and 20 parts of Pfansteihls, fully mix, to being homogeneous powder powder;
4, by the uniform powder obtaining in sealed plastic film bag standing 12 days;
5, reaction is finished and the stable prod of caking is pulverized and crosses 16-20 mesh sieve in oscillating granulator, obtains anti-oxidant high temperature resistant Mercaptamine preparation, sampling inspection cysteine hydrochloride content 54.4%, detect qualified after, pack and put in storage.
Embodiment 3
1, Mercaptamine boiling water bath in plastic containers is processed 16 hours until melt completely;
2,55 parts of melting Mercaptamines are slowly added in 20 deal white carbons under stirring, continue to stir 20 minutes, until be homogeneous powder powder;
3, in Mercaptamine and white carbon uniform powder, add 10 parts of dihydropyridines and 15 parts of Pfansteihls, fully mix, to being homogeneous powder powder;
4, by the uniform powder obtaining in sealed plastic film bag standing 10 days;
5, reaction is finished and the stable prod of caking is pulverized and crosses 20 mesh sieves in oscillating granulator, obtains anti-oxidant high temperature resistant Mercaptamine preparation, sampling inspection cysteine hydrochloride content 53.4%, detect qualified after, pack and put in storage.
Embodiment 4
Anti-oxidant high temperature resistant Mercaptamine preparation is in the application promoting in pig growth
1, Mercaptamine preparation embodiment 2 being obtained mixes by 0.5% with feed, directly feeding.
2, result of the test
Experimental subjects is certain commodity pork pig, 200 every group.
Control group: daily ration, nutritional labeling and feeding and management etc. are undertaken by the conventional method on pig farm.
Experimental group: add 0.5% anti-oxidant high temperature resistant Mercaptamine preparation in feed, other daily ration, nutritional labeling and feeding and management are identical with control group.
Result of the test is as table 1:
Result shows: experimental group is compared with control group, this Mercaptamine preparation not only can effectively improve market pig growth rate and lean meat percentage, its daily gain is for improving 10.5%, a little more than publication number, be CN 102302088 A Chinese invention patent 10.2%, and because Pfansteihl has the effect of the gastrointestinal function of improvement, use this invention product can reduce diarrhea rate simultaneously.
Embodiment 5
Anti-oxidant high temperature resistant Mercaptamine preparation is in the application promoting on growth of meat chicken
1, Mercaptamine preparation embodiment 2 being obtained mixes by 0.5% with feed, directly feeding.
2, result of the test
Experimental subjects is the broiler chicken of certain meat sold on the market chicken house, 600 every group.
Control group: daily ration, nutritional labeling and feeding and management etc. are undertaken by the conventional method on pig farm.
Experimental group: add 0.5% anti-oxidant high temperature resistant Mercaptamine preparation in feed, other daily ration, nutritional labeling and feeding and management are identical with control group.
Result shows: experimental group broiler chicken and control group comparison, average weight gain obviously improves, and simultaneously because Pfansteihl has the effect of the gastrointestinal function of improvement, uses this invention product can reduce broiler chicken diarrhea rate and reduce the death rate simultaneously.
The anti-oxidant high temperature resistant Mercaptamine of table 3 is stored and the front and back changes of contents table of granulating
From table 3, embodiment 2 products place two months with high temperature granulating after Mercaptamine active ingredient reservation 97.6% and 97.2%, the stability that coated Mercaptamine prepared by the embodiment of the present invention is described is fine, wherein the stability of embodiment 3 is good compared with embodiment 1, and the stability of embodiment 2 is more much better than embodiment 3, so the present invention has solved the problem of Mercaptamine poor stability really.
Claims (6)
1. a preparation method for Mercaptamine preparation, is characterized in that it comprises the steps:
(1) Mercaptamine boiling water bath in plastic containers is processed 15-16 hour until melt completely;
(2) melting Mercaptamine step (1) being obtained slowly adds in the white carbon under stirring, continues to stir 20-30 minute, until be homogeneous powder powder;
(3) in the uniform powder obtaining toward step (2), add 6-14 part dihydropyridine and 10-20 part Pfansteihl, fully mix, to being homogeneous powder powder;
(4) uniform powder standing 5-12 days in sealed plastic film bag will be obtained in step (3);
(5) product obtaining in step (4) pulverized and crossed 16-20 mesh sieve in oscillating granulator, obtaining anti-oxidant resistant to elevated temperatures Mercaptamine preparation; Mercaptamine preparation is comprised of the component of following weight portion: Mercaptamine 50-55 part, Pfansteihl 10-20 part, dihydropyridine 6-14 part, white carbon 11-39 part; First Mercaptamine evenly adsorbs with white carbon, and dihydropyridine and Pfansteihl are uniformly distributed in Mercaptamine skin.
2. the preparation method of Mercaptamine preparation according to claim 1, is characterized in that 55 parts of Mercaptamines, 20 parts of Pfansteihls, 14 parts of dihydropyridines, 11 parts of white carbons.
3. a preparation method for Mercaptamine preparation, is characterized in that it comprises the steps:
(1) Mercaptamine boiling water bath in plastic containers is processed 15-16 hour until melt completely;
(2) melting Mercaptamine step (1) being obtained slowly adds in the white carbon under stirring, continues to stir 20-30 minute, until be homogeneous powder powder;
(3) in the uniform powder obtaining toward step (2), add 6-14 part dihydropyridine and 10-20 part Pfansteihl, fully mix, to being homogeneous powder powder;
(4) uniform powder standing 5-12 days in sealed plastic film bag will be obtained in step (3);
(5) product obtaining in step (4) pulverized and crossed 16-20 mesh sieve in oscillating granulator, obtaining anti-oxidant resistant to elevated temperatures Mercaptamine preparation.
4. according to the preparation method of the Mercaptamine preparation described in claim 3, it is characterized in that being formed by the component of following weight portion: Mercaptamine 50-55 part, Pfansteihl 10-20 part, dihydropyridine 6-14 part, white carbon 11-39 part.
5. according to the preparation method of the Mercaptamine preparation described in claim 3, it is characterized in that first Mercaptamine evenly adsorbs with white carbon, dihydropyridine and Pfansteihl are uniformly distributed in Mercaptamine skin.
6. according to the preparation method of the Mercaptamine preparation described in claim 3; it is characterized in that even pulverulent mixture standing 5-12 days in airtight polybag that step (3) obtains, by slow chemical reaction, exhaust bag internal oxygen gas and form diaphragm on Mercaptamine surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410269573.4A CN104000027B (en) | 2013-05-08 | 2013-05-08 | The preparation method of Mercaptamine preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310167287.2A CN103222550B (en) | 2013-05-08 | 2013-05-08 | Preparation method of anti-oxidative high-temperature-resistant cysteamine hydrochloride preparation, and application of preparation |
| CN201410269573.4A CN104000027B (en) | 2013-05-08 | 2013-05-08 | The preparation method of Mercaptamine preparation |
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| CN201310167287.2A Division CN103222550B (en) | 2013-05-08 | 2013-05-08 | Preparation method of anti-oxidative high-temperature-resistant cysteamine hydrochloride preparation, and application of preparation |
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| CN104000027A true CN104000027A (en) | 2014-08-27 |
| CN104000027B CN104000027B (en) | 2016-05-25 |
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| CN201410269486.9A Active CN104026350B (en) | 2013-05-08 | 2013-05-08 | Mercaptamine preparation and application thereof |
| CN201410269573.4A Active CN104000027B (en) | 2013-05-08 | 2013-05-08 | The preparation method of Mercaptamine preparation |
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| CN201410269486.9A Active CN104026350B (en) | 2013-05-08 | 2013-05-08 | Mercaptamine preparation and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108719630A (en) * | 2017-04-16 | 2018-11-02 | 韦智 | A kind of concentrated feed promoting animal health growth containing Mercaptamine feed addictive |
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| CN103222550B (en) * | 2013-05-08 | 2014-07-16 | 济南海华生物科技有限公司 | Preparation method of anti-oxidative high-temperature-resistant cysteamine hydrochloride preparation, and application of preparation |
| CN105341384A (en) * | 2015-12-05 | 2016-02-24 | 湖北犇跃农业发展有限公司 | Feed additive for producing selenium-rich beef |
| CN109479766A (en) * | 2018-11-14 | 2019-03-19 | 浙江海洋大学 | Bream artificial cultivating method |
| CN110813210A (en) * | 2019-11-27 | 2020-02-21 | 衡阳丰联精细化工有限公司 | Apparatus for producing of cysteamine hydrochloride |
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Also Published As
| Publication number | Publication date |
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| CN103222550B (en) | 2014-07-16 |
| CN103222550A (en) | 2013-07-31 |
| CN104000027B (en) | 2016-05-25 |
| CN104026350A (en) | 2014-09-10 |
| CN104026350B (en) | 2016-05-25 |
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