CN103222550A - Preparation method of anti-oxidative high-temperature-resistant cysteamine hydrochloride preparation, and application of preparation - Google Patents
Preparation method of anti-oxidative high-temperature-resistant cysteamine hydrochloride preparation, and application of preparation Download PDFInfo
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- CN103222550A CN103222550A CN2013101672872A CN201310167287A CN103222550A CN 103222550 A CN103222550 A CN 103222550A CN 2013101672872 A CN2013101672872 A CN 2013101672872A CN 201310167287 A CN201310167287 A CN 201310167287A CN 103222550 A CN103222550 A CN 103222550A
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A preparation method of an anti-oxidative high-temperature-resistant cysteamine hydrochloride preparation is characterized in that the method comprises the following steps: 1, processing cysteamine hydrochloride in a boiling water bath in a plastic container for 15-16h to complete melt; 2, slowly adding 55 parts of the obtained molten cysteamine hydrochloride to white carbon black having a same weight with cysteamine hydrochloride and in a stirring state, and continuously stirring for 20-30min to obtain uniform powder; 3, adding 6-14 parts of dihydropyridine and 10-20 parts of L-lactic acid to the obtained uniform powder, and fully and uniformly mixing to obtain uniform powder; 4, allowing the uniform powder obtained in step 3 to stand in a sealed plastic film bag for 5-12 days; and 5, crushing a product obtained in step 4 in an oscillating granulator, and sieving by a 16-20 mesh sieve to obtain the anti-oxidative high-temperature-resistant cysteamine hydrochloride preparation. The obtained cysteamine hydrochloride preparation can be mixed with a forage to obtain a mixture according to a cysteamine hydrochloride preparation/forage ratio of 0.5:100, and the mixture can be used for directly feeding animals in order to effectively raise the growth rates and the carcass qualities of the animals, raise the productivity and reduce the cost.
Description
Technical field
The present invention relates to the preparation of anti-oxidant high temperature resistant Mercaptamine preparation and the application on livestock and poultry cultivation thereof; being specifically related to a kind of is raw material with the Mercaptamine, by add the regulation and control of anti-oxidant protective agent and technology obtain to have high antioxygenic property the Mercaptamine preparation the preparation method and promoting growth of animals or poultry and improving application on its carcass quality.
Background technology
Cysteamine is the metabolite of NAC in the animal body, is the important composition composition of coacetylase.Studies have shown that both at home and abroad cysteamine can promote the secretion of somatotropin and strengthen gastral physiological function, and reach the effect that improves growth of animal performance and carcass quality indirectly by exhaustion animal body somatostatin (SS).It is because hormone to the inhibitory action of the synthetic key enzyme of fat, causes the synthetic and fat minimizing of fat, the result that fat deposition lowers that cysteamine reduces fat.
L-lactic acid is the metabolite of nature in the animal body, and it is added in the feed as acidulant, can not stay harmful substance in animal body.Add L-lactic acid in the animal feed and can reduce stomach inner pH value, make acid-base balance in the animal body, improve digestive enzyme activity, reduce the pH value of feed and alimentary canal front portion.In addition, L-lactic acid can increase beneficial bacterium quantity in the alimentary canal, effectively suppresses the harmful microbe necessary condition, also can improve growth of animal performance and efficiency of feed utilization, reaches the purpose that strengthens body resistance against diseases.
Dihydropyridine is a kind of novel multifunctional additive with natural antioxidant effect, can suppress the peroxidating process of lipoid substance, forms the liver protective layer; Have grease and vitamin V A, the not oxidized antioxidation of carrotene in the protection feed.Simultaneously, can also change some hormonal readiness in the serum, promote animal growth and development, improve the milking capacity of reproductive performance and dam, and strengthen immunologic function, and its metabolism fully, almost noresidue.
Cysteamine is a white crystals, and extremely unstable in air, easily oxidation is made generally in hydrochloride, keeps in Dark Place.Because its easily oxidized characteristic causes it must suitably handle in process of production, otherwise just can lose efficacy because of oxidized.Publication number is the slow-release pill that the Chinese invention patent application of CN101653426A discloses a kind of high-stability type cysteamine hydrochloride, forms by Mercaptamine, silica and as dressing wall material macromolecular material.Preparation technology's more complicated of this slow-release pill, and capsulating material is macromolecular material, it is not enough to be easy to cause the active ingredient Mercaptamine to discharge in enteron aisle, causes wastage of material.Publication number is that the Chinese invention patent of CN 102302088 A discloses a kind of bag by Mercaptamine and preparation method thereof, grinds to form milky white liquid in the order adding colloid mill by stearic acid-cellulose aqueous solution-Mercaptamine-citric acid; Add in the white carbon under the stirring, obtain loose shape white powder.Though this technology is stipulated in proper order to the interpolation of capsulating material; but because stearic acid, cellulose aqueous solution, Mercaptamine and four kinds of liquid of citric acid finally are mixings under the effect of colloid mill; so can't guarantee all Mercaptamines can both be adequately protected; be not subjected to air oxidation, therefore can cause product stability and effect to descend.
Summary of the invention
(be difficult to degraded and absorption as capsulating material, it is not enough to cause Mercaptamine to discharge to the objective of the invention is to overcome the deficiencies in the prior art; Coating is insufficient; cause the Mercaptamine oxidized etc.) and provide a kind of and have antioxygenic property by utilization; easily digested and assimilated and have growth promotion and form protective layer on the Mercaptamine surface with the material of regulating gastrointestinal function by animal; to reach the simplification production technology; reduce production costs; the protection Mercaptamine; strengthen clinical result of use; further enlarge the anti-oxidant high temperature resistant Mercaptamine formulation preparation method of use; anti-oxidant protective agent of the present invention is easy to be digested and assimilated by animal; guarantee the abundant release and the absorption of active ingredient Mercaptamine on the one hand; capsulating material can be used as active ingredient promotion growth of animal simultaneously on the other hand; reduce diarrhea rate, reduced production cost.
Another object of the present invention provides a kind of anti-oxidant high temperature resistant Mercaptamine preparation that has important application in its feeding field.
The purpose of invention is achieved in that a kind of anti-oxidant high temperature resistant Mercaptamine preparation, it is characterized in that it is made up of the component of following weight portion: Mercaptamine 50-55 part, L-lactic acid 10-20 part, dihydropyridine 6-14 part, white carbon 11-39 part.
Concrete technology of the present invention is as follows: a kind of preparation method of anti-oxidant high temperature resistant Mercaptamine preparation is characterized in that it comprises the steps:
(1) Mercaptamine boiling water bath in plastic containers is handled 15-16 hour until melting fully;
(2) the fusion Mercaptamine that step (1) is obtained slowly adds in the white carbon under the stirring, continues to stir 20-30 minute, until being the homogeneous powder powder;
(3) add 6-14 part dihydropyridine and 10-20 part L-lactic acid in the uniform powder that obtains toward step (2), abundant mixing is to being the homogeneous powder powder;
(4) in the sealed plastic film bag, left standstill 5-12 days obtaining uniform powder in the step (3);
(5) product that obtains in the step (4) is pulverized and crossed the 16-20 mesh sieve in oscillating granulator, obtain anti-oxidant high temperature resistant Mercaptamine preparation.
The concrete characteristics of this programme also have, and Mercaptamine at first evenly adsorbs with white carbon, and dihydropyridine and L-lactic acid are uniformly distributed in the Mercaptamine skin.
The even pulverulent mixture that step (3) obtains left standstill in airtight polybag 5-12 days, exhausted bag internal oxygen gas and formed diaphragm on the Mercaptamine surface by slow chemical reaction.
A kind of application of anti-oxidant high temperature resistant Mercaptamine preparation is characterized in that anti-oxidant high temperature resistant Mercaptamine preparation is used as feed addictive on livestock and poultry cultivation.
Anti-oxidant high temperature resistant Mercaptamine preparation mixes the livestock and poultry of directly feeding with feed with 0.5% ratio.
The present invention has following good effect: 1, dihydropyridine and the L-lactic acid animal absorbability as the anti-oxidation protection layer is good; not oxidized and improve the product heat-resisting ability except protecting Mercaptamine; dihydropyridine can promote growth of animal; L-lactic acid can improve animal gastrointestinal tract; reduce diarrhea rate; compare with the common macromolecule capsulating material that is difficult to be absorbed by animal; not only can protect Mercaptamine not oxidized; and can growth promotion and reduce diarrhea rate, reduced production cost.
2, pass through 5-12 days stationary phase in the preparation process; this process anti-oxidation protection material is by consuming the oxygen in the environment; cause oxygen-free environment protection Mercaptamine on the one hand; course of reaction forms even diaphragm by chemical reaction at product surface on the other hand, improves the anti-oxidant heat-resisting ability of product.
3, be that the diaphragm that dominant shape becomes is degraded easily with dihydropyridine and L-lactic acid, be convenient to Mercaptamine and discharge fast and absorbed, avoid being excreted, and then improve the utilization rate of active ingredient because of discharging by body.
4, anti-oxidant high temperature resistant technology makes that product not only can be by dioxygen oxidation in the air, improved the tolerance of product simultaneously to high temperature, therefore said preparation can tolerate the high temperature of feed high temperature granulating process and extruding etc., can directly make an addition in the pellet and guarantees the active unaffected of Mercaptamine.
In addition; because being dihydropyridine and L-lactic acid, the anti-oxidant protective agent that the present invention adopts has growth promotion, anti-oxidant and improve the effect of gastrointestinal function; compare with other similar Mercaptamine patent of invention; the embodiment product shows the effect of tangible reduction diarrhoea incidence except having the Mercaptamine growth promotion, improving the direct effect of lean meat percentage in growing and fattening pigs and feeding of broiler embodiment.Illustrate that this inventive method not only can improve the anti-oxidant and heat-resistant stable of Mercaptamine, the invention product has the effect that promotes growth of animals or poultry, improves lean meat percentage and reduction diarrhoea incidence simultaneously.The present invention is by adopting protective layer material and the anti-oxidant high temperature resistant production technology that absorbs easily; guaranteed the activity of Mercaptamine; improved the absorptivity of body to Mercaptamine; improved product effectiveness; reduced production cost; strengthened its effect on livestock and poultry cultivation, made product have stronger competitiveness.
Description of drawings
Fig. 1 is a process chart of the present invention.
The specific embodiment
Embodiment 1
1, Mercaptamine boiling water bath in plastic containers is handled 15 hours until melting fully;
2,55 parts of fusion Mercaptamines are slowly added in the 29 deal white carbons under the stirring, continue to stir 30 minutes, until being the homogeneous powder powder;
3, add 6 parts of dihydropyridines and 10 parts of L-lactic acid in Mercaptamine and white carbon uniform powder, abundant mixing is to being the homogeneous powder powder;
4, the uniform powder that obtains was left standstill in the sealed plastic film bag 7 days;
5, the stable prod that will react end and caking is pulverized in oscillating granulator and mistake 16 mesh sieves, obtains anti-oxidant high temperature resistant Mercaptamine preparation.Sampling inspection cysteine hydrochloride content 52.9%, detects qualified after, packing is put in storage.
Embodiment 2
1, Mercaptamine boiling water bath in plastic containers is handled 16 hours until melting fully;
2,55 parts of fusion Mercaptamines slowly are added 11 under the stirring? in the deal white carbon, continue to stir 30 minutes, until being the homogeneous powder powder;
3, add 14 parts of dihydropyridines and 20 parts of L-lactic acid in Mercaptamine and white carbon uniform powder, abundant mixing is to being the homogeneous powder powder;
4, the uniform powder that obtains was left standstill in the sealed plastic film bag 12 days;
5, will react and finish and the stable prod of caking is pulverized in oscillating granulator and crossed the 16-20 mesh sieve, obtain anti-oxidant high temperature resistant Mercaptamine preparation, sampling inspection cysteine hydrochloride content 54.4%, detects qualified after, pack and put in storage.
Embodiment 3
1, Mercaptamine boiling water bath in plastic containers is handled 16 hours until melting fully;
2,55 parts of fusion Mercaptamines are slowly added in the 20 deal white carbons under the stirring, continue to stir 20 minutes, until being the homogeneous powder powder;
3, add 10 parts of dihydropyridines and 15 parts of L-lactic acid in Mercaptamine and white carbon uniform powder, abundant mixing is to being the homogeneous powder powder;
4, the uniform powder that obtains was left standstill in the sealed plastic film bag 10 days;
5, will react and finish and the stable prod of caking is pulverized in oscillating granulator and crossed 20 mesh sieves, obtain anti-oxidant high temperature resistant Mercaptamine preparation, sampling inspection cysteine hydrochloride content 53.4%, detects qualified after, pack and put in storage.
Embodiment 4
Anti-oxidant high temperature resistant Mercaptamine preparation is in the application that promotes in the pig growth
1, the Mercaptamine preparation that embodiment 2 is obtained mixes by 0.5% with feed, directly feeding.
2, result of the test
Experimental subjects is certain commodity pork pig, 200 every group.
Control group: daily ration, nutritional labeling and feeding and management etc. are undertaken by the conventional method on pig farm.
Experimental group: add 0.5% anti-oxidant high temperature resistant Mercaptamine preparation in the feed, other daily ration, nutritional labeling and feeding and management are identical with control group.
Result of the test such as table 1:
The result shows: experimental group is compared with control group, this Mercaptamine preparation not only can effectively improve market pig growth rate and lean meat percentage, its daily gain is for improving 10.5%, a little more than publication number be CN 102302088 A Chinese invention patent 10.2%, and, use this invention product can reduce diarrhea rate simultaneously because L-lactic acid has the effect of the gastrointestinal function of improvement.
Embodiment 5
Anti-oxidant high temperature resistant Mercaptamine preparation is in the application that promotes on the growth of meat chicken
1, the Mercaptamine preparation that embodiment 2 is obtained mixes by 0.5% with feed, directly feeding.
2, result of the test
Experimental subjects is the fryer of certain meat sold on the market chicken house, 600 every group.
Control group: daily ration, nutritional labeling and feeding and management etc. are undertaken by the conventional method on pig farm.
Experimental group: add 0.5% anti-oxidant high temperature resistant Mercaptamine preparation in the feed, other daily ration, nutritional labeling and feeding and management are identical with control group.
The result shows: experimental group fryer and control group compare, and average weight gain obviously improves, and simultaneously because L-lactic acid has the effect of the gastrointestinal function of improvement, use this invention product can reduce the fryer diarrhea rate and reduce the death rate simultaneously.
The anti-oxidant high temperature resistant Mercaptamine of table 3 is stored and the front and back content table of granulating
By table 3 as can be known, embodiment 2 products place two months with high temperature granulating after Mercaptamine active ingredient reservation 97.6% and 97.2%, the bag that embodiment of the invention preparation is described is stable fine by Mercaptamine, wherein the stability of embodiment 3 is good than embodiment 1, and the stability of embodiment 2 is more much better than embodiment 3, so the present invention has solved the problem of Mercaptamine poor stability really.
Claims (7)
1. anti-oxidant high temperature resistant Mercaptamine preparation is characterized in that it is made up of the component of following weight portion: Mercaptamine 50-55 part, L-lactic acid 10-20 part, dihydropyridine 6-14 part, white carbon 11-39 part.
2. the preparation method of an anti-oxidant high temperature resistant Mercaptamine preparation is characterized in that it comprises the steps:
(1) Mercaptamine boiling water bath in plastic containers is handled 15-16 hour until melting fully;
(2) the fusion Mercaptamine that step (1) is obtained slowly adds in the white carbon under the stirring, continues to stir 20-30 minute, until being the homogeneous powder powder;
(3) add 6-14 part dihydropyridine and 10-20 part L-lactic acid in the uniform powder that obtains toward step (2), abundant mixing is to being the homogeneous powder powder;
(4) in the sealed plastic film bag, left standstill 5-12 days obtaining uniform powder in the step (3);
(5) product that obtains in the step (4) is pulverized and crossed the 16-20 mesh sieve in oscillating granulator, obtain anti-oxidant high temperature resistant Mercaptamine preparation.
3. according to the described anti-oxidant high temperature resistant Mercaptamine formulation preparation of claim 2, it is characterized in that forming: Mercaptamine 50-55 part, L-lactic acid 10-20 part, dihydropyridine 6-14 part, white carbon 11-39 part by the component of following weight portion.
4. according to the described anti-oxidant high temperature resistant Mercaptamine formulation preparation method of claim 2, it is characterized in that Mercaptamine at first evenly adsorbs with white carbon, dihydropyridine and L-lactic acid are uniformly distributed in the Mercaptamine skin.
5. according to the described anti-oxidant high temperature resistant Mercaptamine formulation preparation method of claim 2; it is characterized in that the even pulverulent mixture that step (3) obtains left standstill 5-12 days in airtight polybag, exhaust bag internal oxygen gas and form diaphragm on the Mercaptamine surface by slow chemical reaction.
6. the application of an anti-oxidant high temperature resistant Mercaptamine preparation as claimed in claim 1 is characterized in that anti-oxidant high temperature resistant Mercaptamine preparation is used as feed addictive on livestock and poultry cultivation.
7. the application process of anti-oxidant high temperature resistant Mercaptamine preparation according to claim 6 is characterized in that anti-oxidant high temperature resistant Mercaptamine preparation mixes the livestock and poultry of directly feeding with feed with 0.5% ratio.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410269573.4A CN104000027B (en) | 2013-05-08 | 2013-05-08 | The preparation method of Mercaptamine preparation |
| CN201410269486.9A CN104026350B (en) | 2013-05-08 | 2013-05-08 | Mercaptamine preparation and application thereof |
| CN201310167287.2A CN103222550B (en) | 2013-05-08 | 2013-05-08 | Preparation method of anti-oxidative high-temperature-resistant cysteamine hydrochloride preparation, and application of preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310167287.2A CN103222550B (en) | 2013-05-08 | 2013-05-08 | Preparation method of anti-oxidative high-temperature-resistant cysteamine hydrochloride preparation, and application of preparation |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410269486.9A Division CN104026350B (en) | 2013-05-08 | 2013-05-08 | Mercaptamine preparation and application thereof |
| CN201410269573.4A Division CN104000027B (en) | 2013-05-08 | 2013-05-08 | The preparation method of Mercaptamine preparation |
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| CN103222550A true CN103222550A (en) | 2013-07-31 |
| CN103222550B CN103222550B (en) | 2014-07-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410269573.4A Active CN104000027B (en) | 2013-05-08 | 2013-05-08 | The preparation method of Mercaptamine preparation |
| CN201410269486.9A Active CN104026350B (en) | 2013-05-08 | 2013-05-08 | Mercaptamine preparation and application thereof |
| CN201310167287.2A Active CN103222550B (en) | 2013-05-08 | 2013-05-08 | Preparation method of anti-oxidative high-temperature-resistant cysteamine hydrochloride preparation, and application of preparation |
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| CN201410269573.4A Active CN104000027B (en) | 2013-05-08 | 2013-05-08 | The preparation method of Mercaptamine preparation |
| CN201410269486.9A Active CN104026350B (en) | 2013-05-08 | 2013-05-08 | Mercaptamine preparation and application thereof |
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| CN109479766A (en) * | 2018-11-14 | 2019-03-19 | 浙江海洋大学 | Bream artificial cultivating method |
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| CN104000027B (en) * | 2013-05-08 | 2016-05-25 | 济南海华生物科技有限公司 | The preparation method of Mercaptamine preparation |
| CN105341384A (en) * | 2015-12-05 | 2016-02-24 | 湖北犇跃农业发展有限公司 | Feed additive for producing selenium-rich beef |
| CN108719630A (en) * | 2017-04-16 | 2018-11-02 | 韦智 | A kind of concentrated feed promoting animal health growth containing Mercaptamine feed addictive |
| CN110813210A (en) * | 2019-11-27 | 2020-02-21 | 衡阳丰联精细化工有限公司 | Apparatus for producing of cysteamine hydrochloride |
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