CN116349787A - Milk cow postpartum fast and long-acting calcium supplementing preparation and preparation method thereof - Google Patents
Milk cow postpartum fast and long-acting calcium supplementing preparation and preparation method thereof Download PDFInfo
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- CN116349787A CN116349787A CN202310417331.4A CN202310417331A CN116349787A CN 116349787 A CN116349787 A CN 116349787A CN 202310417331 A CN202310417331 A CN 202310417331A CN 116349787 A CN116349787 A CN 116349787A
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 48
- 239000011575 calcium Substances 0.000 title claims abstract description 48
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 48
- 238000002360 preparation method Methods 0.000 title claims abstract description 36
- 230000001502 supplementing effect Effects 0.000 title claims abstract description 13
- 235000013336 milk Nutrition 0.000 title description 3
- 239000008267 milk Substances 0.000 title description 3
- 210000004080 milk Anatomy 0.000 title description 3
- 239000000463 material Substances 0.000 claims abstract description 121
- 239000011248 coating agent Substances 0.000 claims abstract description 110
- 238000000576 coating method Methods 0.000 claims abstract description 110
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 67
- 239000011162 core material Substances 0.000 claims abstract description 64
- 241000283690 Bos taurus Species 0.000 claims abstract description 57
- 239000002131 composite material Substances 0.000 claims abstract description 3
- 239000001110 calcium chloride Substances 0.000 claims description 28
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 28
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 26
- 238000010438 heat treatment Methods 0.000 claims description 26
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 24
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 24
- 239000012530 fluid Substances 0.000 claims description 24
- 238000002844 melting Methods 0.000 claims description 22
- 230000008018 melting Effects 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 235000013365 dairy product Nutrition 0.000 claims description 18
- 239000002994 raw material Substances 0.000 claims description 16
- 239000000377 silicon dioxide Substances 0.000 claims description 13
- 235000012239 silicon dioxide Nutrition 0.000 claims description 13
- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical compound [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 claims description 12
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 12
- 239000004330 calcium propionate Substances 0.000 claims description 12
- 235000010331 calcium propionate Nutrition 0.000 claims description 12
- GMRQFYUYWCNGIN-ZVUFCXRFSA-N 1,25-dihydroxy vitamin D3 Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-ZVUFCXRFSA-N 0.000 claims description 11
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 11
- 229940069978 calcium supplement Drugs 0.000 claims description 11
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims description 11
- 229910052901 montmorillonite Inorganic materials 0.000 claims description 11
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 11
- 235000011152 sodium sulphate Nutrition 0.000 claims description 11
- 210000002784 stomach Anatomy 0.000 claims description 10
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 8
- 238000003825 pressing Methods 0.000 claims description 8
- 235000019482 Palm oil Nutrition 0.000 claims description 7
- 239000002540 palm oil Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 5
- 239000004925 Acrylic resin Substances 0.000 claims description 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
- 235000021355 Stearic acid Nutrition 0.000 claims description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 5
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 5
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 5
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 5
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 5
- 239000000661 sodium alginate Substances 0.000 claims description 5
- 235000010413 sodium alginate Nutrition 0.000 claims description 5
- 229940005550 sodium alginate Drugs 0.000 claims description 5
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 5
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 5
- 239000008117 stearic acid Substances 0.000 claims description 5
- 238000009472 formulation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 abstract description 20
- 239000008280 blood Substances 0.000 abstract description 20
- 210000004767 rumen Anatomy 0.000 abstract description 9
- 238000010521 absorption reaction Methods 0.000 abstract description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 3
- 229960005084 calcitriol Drugs 0.000 abstract description 2
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract description 2
- GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 abstract 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 229910001424 calcium ion Inorganic materials 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 244000144972 livestock Species 0.000 description 5
- 159000000007 calcium salts Chemical class 0.000 description 4
- 238000005507 spraying Methods 0.000 description 4
- 230000007794 irritation Effects 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 244000144977 poultry Species 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000003674 animal food additive Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 208000013038 Hypocalcemia Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- -1 anion salt Chemical class 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000000705 hypocalcaemia Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
- A23K40/35—Making capsules specially adapted for ruminants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Inorganic Chemistry (AREA)
- Birds (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a quick and long-acting calcium supplementing preparation for cows after delivery and a preparation method thereof, wherein the quick and long-acting calcium supplementing preparation for cows after delivery comprises a core material and a coating material coated on the periphery of the core material, and the core material consists of a section A and a section B; the section A of the core material consists of anhydrous calcium chloride and a carrier A which can be rapidly dissolved and released in rumen; the section B of the core material consists of anhydrous calcium chloride and a carrier B which can be slowly released in rumen; the coating material comprises a coating material A and a coating material B; the coating material A is coated on the periphery of the core material A section, and the coating material B is coated on the periphery of the core material B section. The composite coated calcium rod material is obtained by adopting a combination form of the quick release type A section and the slow release type B section, so that the blood calcium of postpartum cows can be quickly improved, and meanwhile, the high blood calcium level (more than 24 hours) can be maintained for a long time; meanwhile, the formula contains rumen bypass active 1, 25-dihydroxyvitamin D3, stimulates the intestinal tract to absorb more calcium, and improves the absorption and utilization rate of the calcium.
Description
Technical Field
The invention relates to the technical field of calcium preparation, in particular to a rapid and long-acting calcium supplementing preparation for dairy cows after delivery and a preparation method thereof.
Background
Feed-grade calcium chloride is a chemical substance consisting of chlorine element and calcium element. The calcium chloride is often used as an anion salt additive to be applied to feed, has the functions of supplementing calcium ions required by livestock, improving acid-base balance of body fluid of livestock and the like, can effectively increase the concentration of free calcium in blood, can be used for preventing postpartum hypocalcemia of cows and reducing the occurrence of postpartum paralysis and other diseases, and is beneficial to improving the reproductive performance of the cows.
Calcium chloride as a feed additive itself is prone to moisture absorption, which can cause the feed to cake and destroy its nutrients. Calcium chloride is heated when meeting water, has certain irritation, can cause burn of oral cavity and esophagus of livestock and poultry, can easily cause refusal of food for livestock and poultry when being directly fed, and has strong irritation to organism tissues of livestock and poultry. In addition, calcium chloride is very soluble in water and is quickly absorbed and utilized in the gastrointestinal tract of dairy cows, so that the concentration of calcium in blood can be quickly increased, but the maintenance time is generally not long, so that the calcium chloride is necessary to be subjected to slow release treatment when the calcium chloride is applied to the feed of the dairy cows.
The coated calcium chloride is coated by selecting different types of coating materials, so that the calcium chloride is prevented from absorbing moisture and agglomerating as much as possible, the irritation of the calcium chloride to organisms is reduced, and meanwhile, the calcium chloride is slowly released in the rumen of the dairy cows, so that the postpartum high blood calcium level of the dairy cows is maintained for a long time. The invention patent with the publication number of CN104585480B discloses coated calcium chloride and a preparation method thereof, wherein the coated calcium chloride comprises the following raw materials in parts by weight: 5-20 parts of hydrogenated palm oil; 5-20 parts of hydrogenated castor oil; 4-30 parts of silicon dioxide; 1-20 parts of fatty acid calcium; 60-85 parts of calcium chloride. The invention uses hydrogenated palm oil, hydrogenated castor oil, silicon dioxide and fatty acid calcium as packing materials, uses calcium chloride as core materials, and obtains the coated calcium chloride which can be used as feed additive through a multiple granulating and coating technology.
However, the coated calcium chloride is easy to release in rumen of the dairy cows not timely or release too short, so that calcium supplement is not timely, high blood calcium level of about 6 hours can be maintained, and the dairy cows still have low blood calcium on 4 th post partum, so that the dairy cows need to be fed once at intervals, and the operation is very complicated.
Therefore, it is very necessary to design a rapid and long-acting calcium supplementing preparation special for dairy cows.
Disclosure of Invention
The invention provides a rapid and long-acting calcium supplement preparation for cows after delivery and a preparation method thereof, which not only can rapidly increase the blood calcium level of cows after delivery, but also can maintain the high calcium level in blood for a long time and reduce the use frequency of coated calcium salt materials.
The specific technical scheme is as follows:
the invention provides a quick and long-acting calcium supplementing preparation for dairy cows after delivery, which comprises a core material and a coating material coated on the periphery of the core material, wherein the core material consists of a section A and a section B; the section A of the core material consists of anhydrous calcium chloride and a carrier A which can be rapidly dissolved and released in the stomach of a cow; the section B of the core material consists of anhydrous calcium chloride and a carrier B which can be slowly released in the stomach of a cow; the coating material comprises a coating material A and a coating material B; the coating material A is coated on the periphery of the core material A section, and the coating material B is coated on the periphery of the core material B section.
Further, the carrier A comprises calcium propionate, silicon dioxide, montmorillonite and sodium sulfate; the dosage ratio of the anhydrous calcium chloride to the calcium propionate, the silicon dioxide, the montmorillonite and the sodium sulfate is as follows: 50-70:5-15:5-15:10-20. The carrier A adopts the materials with higher water solubility, such as calcium propionate, silicon dioxide, montmorillonite and sodium sulfate, and can rapidly release calcium ions so as to satisfy rapid absorption of calcium ions by postpartum cows.
The solubility of different calcium salts in water varies: calcium propionate is easily soluble in water; calcium sulfate is slightly soluble in water; calcium carbonate is hardly soluble in water, but can react with hydrochloric acid to form calcium chloride. Therefore, the release speed of different calcium salts in the rumen is different, the maintenance level of calcium ions in blood can be influenced after milk cows eat, and the maintenance time of blood calcium can be prolonged by combining calcium salts with different solubilities.
Further, the carrier B comprises calcium carbonate and 1, 25-dihydroxyvitamin D 3 And calcium sulfate; the anhydrous calcium chloride, calcium carbonate and 1, 25-dihydroxyvitamin D 3 And the dosage ratio of the calcium sulfate is as follows: 20-30:4-8:10-20:20-30. Calcium carbonate and 1, 25-dihydroxyvitamin D used as carrier B 3 And the calcium sulfate is a material with lower water solubility, so that calcium ions can be slowly released, and the slow absorption of calcium elements by later post-partum dairy cows can be met.
Further, the coating material A comprises the following raw materials in parts by weight: 30-50 parts of palm oil, 20-25 parts of hydroxypropyl methyl cellulose and 25-30 parts of microcrystalline cellulose.
Further, the coating material B comprises a coating material B 1 And coating material B 2 The method comprises the steps of carrying out a first treatment on the surface of the Wherein the coating material B 1 The material consists of the following raw materials in parts by weight: 20-40 parts of stearic acid and 60-80 parts of sodium alginate; the coating material B 2 The material consists of the following raw materials in parts by weight: 25-40 parts of sodium carboxymethyl cellulose and 60-75 parts of polyacrylic resin; the coating material B is prepared from a coating material B 1 And coating material B 2 Respectively melting and mixing.
Further, the core material is formed by pouring and pressing a fluid section A and a fluid section B; the fluid section A is obtained by mixing anhydrous calcium chloride and a carrier A in water after melting, and the fluid section B is obtained by mixing the anhydrous calcium chloride and a carrier B in water after melting; the mass ratio of the fluid-shaped section A to the fluid-shaped section B is 1:1.
Further, a layer of calcium stearate powder is sprayed on the periphery of the coating material.
The invention also provides a preparation method of the rapid and long-acting calcium supplement preparation for cows after delivery, which comprises the following steps:
(1) Adding anhydrous calcium chloride and a carrier A into water for heating and melting to obtain a fluid section A;
(2) Adding anhydrous calcium chloride and a carrier B into water for heating and melting to obtain a fluid section B;
(3) Pouring and pressing the fluid section A and the fluid section B to obtain a core material;
(4) After heating and dissolving the coating material A, coating the section A of the core material, and solidifying the coating to obtain a section A coated calcium chloride material;
(5) And heating and dissolving the coating material B, coating the section B of the core material, and solidifying the coating to obtain the composite coated calcium rod material coated by the section A and the section B.
Further, after the film in the step (5) is solidified, a layer of calcium stearate powder is sprayed into the whole calcium chloride material.
Further, in the step (1) and the step (2), the temperature of the heating and melting is 80-85 ℃; in the step (4) and the step (5), the temperature of the coating is 90-95 ℃.
Compared with the prior art, the invention has the following beneficial effects:
(1) The invention adopts the combination of the quick release type A section and the slow release type B section to obtain the quick and long-acting calcium supplement preparation for the postpartum cows, and can maintain (more than 24 hours) the high blood calcium level for a long time while quickly improving the blood calcium of the postpartum cows; meanwhile, active dihydroxyvitamin D3 containing rumen is used for stimulating the intestinal tract to absorb more calcium, so that the absorption and utilization rate of calcium is improved.
(2) The coating material of the invention adopts natural ingredients which are easy to disintegrate, and can prevent the blockage of rumen valves and influence the normal physiological functions of rumen.
Detailed Description
The invention will be further described with reference to the following examples, which are given by way of illustration only, but the scope of the invention is not limited thereto.
Example 1
The embodiment provides a rapid and long-acting calcium supplementing preparation for dairy cows after delivery, which consists of a core material and a coating material coated on the periphery of the core material;
the core material consists of a section A and a section B; the section A of the core material consists of anhydrous calcium chloride and a carrier A which can be rapidly dissolved and released in the stomach of a cow; the section B of the core material consists of anhydrous calcium chloride and a carrier B which can be slowly released in the stomach of cattle; the coating materials comprise a coating material A and a coating material B; the coating material A is coated on the periphery of the core material A section, and the coating material B is coated on the periphery of the core material B section. Anhydrous calcium chloride was sieved through a 20 mesh sieve.
The carrier A consists of calcium propionate, silicon dioxide, montmorillonite and sodium sulfate; the dosage ratio of the anhydrous calcium chloride to the calcium propionate, the silicon dioxide, the montmorillonite and the sodium sulfate is as follows: 60:10:10:10:15; the carrier B is prepared from calcium carbonate and 1, 25-dihydroxyvitamin D 3 And calcium sulfate; anhydrous calcium chloride and calcium carbonate, 1, 25-dihydroxyvitamin D 3 And the dosage ratio of the calcium sulfate is as follows: 25:6:15:25. The coating material A consists of the following raw materials in parts by weight: 40 parts of palm oil, 20 parts of hydroxypropyl methyl cellulose and 30 parts of microcrystalline cellulose; the coating material B is formed by coating material B 1 And coating material B 2 Constructing; wherein, the coating material B 1 The material consists of the following raw materials in parts by weight: 30 parts of stearic acid and 70 parts of sodium alginate; coating material B 2 The material consists of the following raw materials in parts by weight: 30 parts of sodium carboxymethyl cellulose and 70 parts of polyacrylic resin.
The preparation method of the rapid and long-acting calcium supplementing preparation for cows after delivery comprises the following specific steps:
(1) Adding anhydrous calcium chloride and a carrier A into water for heating and melting, wherein the temperature of the heating and melting is 80 ℃, and stirring for 10min to obtain a fluid section A;
(2) Adding anhydrous calcium chloride and a carrier B into water for heating and melting, wherein the temperature of the heating and melting is 80 ℃, and stirring for 10min to obtain a fluid section B;
(3) Pouring and pressing the fluid section A and the fluid section B according to the mass ratio of 1:1 to obtain a core material;
(4) After heating and dissolving the coating material A, coating the section A of the core material at 90 ℃, and solidifying the coating to obtain a section A coated calcium chloride material;
(5) And heating and dissolving the coating material B, coating the section B of the core material at 90 ℃, and spraying a layer of calcium stearate powder into the whole calcium chloride material after the coating is solidified to obtain the dairy cow postpartum quick and long-acting calcium supplement preparation coated in the section A and the section B.
Example 2
The embodiment provides a rapid and long-acting calcium supplementing preparation for dairy cows after delivery, which consists of a core material and a coating material coated on the periphery of the core material;
the core material consists of a section A and a section B; the section A of the core material consists of anhydrous calcium chloride and a carrier A which can be rapidly dissolved and released in the stomach of a cow; the section B of the core material consists of anhydrous calcium chloride and a carrier B which can be slowly released in the stomach of cattle; the coating materials comprise a coating material A and a coating material B; the coating material A is coated on the periphery of the core material A section, and the coating material B is coated on the periphery of the core material B section.
The carrier A consists of calcium propionate, silicon dioxide, montmorillonite and sodium sulfate; the dosage ratio of the anhydrous calcium chloride to the calcium propionate, the silicon dioxide, the montmorillonite and the sodium sulfate is as follows: 50:5:15:5:20; the carrier B is prepared from calcium carbonate and 1, 25-dihydroxyvitamin D 3 And calcium sulfate; anhydrous calcium chloride and calcium carbonate, 1, 25-dihydroxyvitamin D 3 And the dosage ratio of the calcium sulfate is as follows: 25:4:20:30. The coating material A consists of the following raw materials in parts by weight: 50 parts of palm oil, 25 parts of hydroxypropyl methyl cellulose and 25 parts of microcrystalline cellulose; the coating material B is formed by coating material B 1 And coating material B 2 Constructing; wherein, the coating material B 1 The material consists of the following raw materials in parts by weight: 40 parts of stearic acid and 60 parts of sodium alginate; coating material B 2 The material consists of the following raw materials in parts by weight: 40 parts of sodium carboxymethyl cellulose and 60 parts of polyacrylic resin.
The preparation method of the rapid and long-acting calcium supplementing preparation for cows after delivery comprises the following specific steps:
(1) Adding anhydrous calcium chloride and a carrier A into water for heating and melting, wherein the temperature of the heating and melting is 80 ℃, and stirring for 10min to obtain a fluid section A;
(2) Adding anhydrous calcium chloride and a carrier B into water for heating and melting, wherein the temperature of the heating and melting is 80 ℃, and stirring for 10min to obtain a fluid section B;
(3) Pouring and pressing the fluid section A and the fluid section B according to the mass ratio of 1:1 to obtain a core material;
(4) After heating and dissolving the coating material A, coating the section A of the core material at 90 ℃, and solidifying the coating to obtain a section A coated calcium chloride material;
(5) And heating and dissolving the coating material B, coating the section B of the core material at 90 ℃, and spraying a layer of calcium stearate powder into the whole calcium chloride material after the coating is solidified to obtain the dairy cow postpartum quick and long-acting calcium supplement preparation coated in the section A and the section B.
Comparative example 1
The embodiment provides a coated calcium rod, which consists of a core material and a coating material coated on the periphery of the core material;
wherein the core material consists of anhydrous calcium chloride and a carrier A which can be rapidly dissolved and released in the stomach of cattle; the coating material is a film material A; the coating material A is coated on the periphery of the core material. Anhydrous calcium chloride was sieved through a 20 mesh sieve.
The carrier A consists of calcium propionate, silicon dioxide, montmorillonite and sodium sulfate; the dosage ratio of the anhydrous calcium chloride to the calcium propionate, the silicon dioxide, the montmorillonite and the sodium sulfate is as follows: 60:10:10:10:15; the coating material A consists of the following raw materials in parts by weight: 40 parts of palm oil, 20 parts of hydroxypropyl methyl cellulose and 30 parts of microcrystalline cellulose.
The preparation method of the coated calcium rod comprises the following specific steps:
(1) Adding anhydrous calcium chloride and a carrier A into water for heating and melting, stirring for 10min at the temperature of 80 ℃ to obtain a fluid core material, and pouring and pressing to obtain the core material;
(2) After heating and dissolving the coating material A, coating the section A of the core material at 90 ℃, and after curing the coating, spraying a layer of calcium stearate powder into the whole calcium chloride material to obtain a coated calcium bar material;
comparative example 2
The embodiment provides a coated calcium rod, which consists of a core material and a coating material coated on the periphery of the core material;
wherein the core material consists of anhydrous calcium chloride and a carrier B which can be slowly released in the stomach of cattle; the coating material comprises a coating material B; the coating material B is coated on the periphery of the core material B section. Anhydrous calcium chloride was sieved through a 20 mesh sieve.
The carrier B is prepared from calcium carbonate and 1, 25-dihydroxyvitamin D 3 And calcium sulfate; anhydrous calcium chloride and calcium carbonate, 1, 25-dihydroxyvitamin D 3 And the dosage ratio of the calcium sulfate is as follows: 25:6:15:25. The coating material B is formed by coating material B 1 And coating material B 2 Constructing; wherein, the coating material B 1 The material consists of the following raw materials in parts by weight: 30 parts of stearic acid and 70 parts of sodium alginate; coating material B 2 The material consists of the following raw materials in parts by weight: 30 parts of sodium carboxymethyl cellulose and 70 parts of polyacrylic resin.
The preparation method of the coated calcium rod comprises the following specific steps:
(1) Adding anhydrous calcium chloride and a carrier B into water for heating and melting, stirring for 10min at the temperature of 80 ℃ to obtain a fluid core material, and pouring and pressing to obtain the core material;
(2) And (3) heating and dissolving the coating material B, coating the core material at 90 ℃, and spraying a layer of calcium stearate powder into the whole calcium chloride material after the coating material B is solidified to obtain the coated calcium rod material.
The materials obtained in examples 1 to 2 and comparative examples 1 to 2 were fed to post-partum cows, and the calcium content in blood of post-partum cows after feeding for different periods of time was measured.
The specific method comprises the following steps: selecting 20 cows, randomly dividing into 2 groups according to the number of the cows, wherein the number of the cows is 10, and the average number of the cows is 3.8; after the postpartum legs are taken, the materials prepared in the examples 1-2 and the comparative examples 1-2 are taken, and the initial blood calcium concentration of the cattle is measured to be T 0 (1.87 mmol/L); blood samples are respectively collected at 0h,1h,6h and 12h after feeding; by dividing the blood calcium concentration at the time point of the sample after the first administration by T 0 To measure the ability to increase blood calcium. The collected blood sample is immediately centrifuged to obtain serum, and the level of ionized calcium in the serum is measured.
The results are shown in Table 1.
Table 1 increases in bovine blood calcium (unit: mmol/L) after administration of the materials of examples 1 to 2 and comparative examples 1 to 2.
The embodiments of the present invention are disclosed as preferred embodiments, but not limited thereto, and those skilled in the art will readily appreciate from the foregoing description that various extensions and modifications can be made without departing from the spirit of the present invention.
Claims (10)
1. The quick and long-acting calcium supplementing preparation for cows after delivery comprises a core material and a coating material coated on the periphery of the core material, and is characterized in that the core material consists of a section A and a section B; the section A of the core material consists of anhydrous calcium chloride and a carrier A which can be rapidly dissolved and released in the stomach of a cow; the section B of the core material consists of anhydrous calcium chloride and a carrier B which can be slowly released in the stomach of a cow; the coating material comprises a coating material A and a coating material B; the coating material A is coated on the periphery of the core material A section, and the coating material B is coated on the periphery of the core material B section.
2. The rapid and long-acting postpartum calcium-supplementing formulation for dairy cows according to claim 1, wherein the carrier a comprises calcium propionate, silicon dioxide, montmorillonite and sodium sulfate; the dosage ratio of the anhydrous calcium chloride to the calcium propionate, the silicon dioxide, the montmorillonite and the sodium sulfate is as follows: 50-70:5-15:5-15:10-20.
3. The rapid and long-acting postpartum calcium preparation for cows of claim 1, wherein the carrier B comprises calcium carbonate, 1, 25-dihydroxyvitamin D 3 And calcium sulfate; the anhydrous calcium chloride, calcium carbonate and 1, 25-dihydroxyvitamin D 3 And the dosage ratio of the calcium sulfate is as follows: 20-30:4-8:10-20:20-30.
4. The rapid and long-acting postpartum calcium supplement preparation for cows of claim 1, wherein the coating material A comprises the following raw materials in parts by weight: 30-50 parts of palm oil, 20-25 parts of hydroxypropyl methyl cellulose and 25-30 parts of microcrystalline cellulose.
5. The rapid and long-acting postpartum calcium-supplementing preparation for dairy cows according to claim 1, wherein the coating material B comprises the coating material B 1 And coating material B 2 The method comprises the steps of carrying out a first treatment on the surface of the Wherein the coating material B 1 The material consists of the following raw materials in parts by weight: 20-40 parts of stearic acid and 60-80 parts of sodium alginate; the coating material B 2 The material consists of the following raw materials in parts by weight: 25-40 parts of sodium carboxymethyl cellulose and 60-75 parts of polyacrylic resin; the coating material B is prepared from a coating material B 1 And coating material B 2 Respectively melting and mixing.
6. The rapid and long-acting postpartum calcium supplement preparation for cows of claim 1, wherein the core material is formed by pouring and pressing a fluid-shaped section A and a fluid-shaped section B; the fluid section A is obtained by mixing anhydrous calcium chloride and a carrier A in water after melting, and the fluid section B is obtained by mixing the anhydrous calcium chloride and a carrier B in water after melting; the mass ratio of the fluid-shaped section A to the fluid-shaped section B is 1:1.
7. The rapid and long-acting postpartum calcium supplement preparation for cows of claim 1, wherein a layer of calcium stearate powder is further sprayed on the periphery of the coating material.
8. A method for preparing the rapid and long-acting calcium supplement preparation for cows after delivery according to any one of claims 1 to 7, which comprises the following steps:
(1) Adding anhydrous calcium chloride and a carrier A into water for heating and melting to obtain a fluid section A;
(2) Adding anhydrous calcium chloride and a carrier B into water for heating and melting to obtain a fluid section B;
(3) Pouring and pressing the fluid section A and the fluid section B to obtain a core material;
(4) After heating and dissolving the coating material A, coating the section A of the core material, and solidifying the coating to obtain a section A coated calcium chloride material;
(5) And heating and dissolving the coating material B, coating the section B of the core material, and solidifying the coating to obtain the composite coated calcium rod material coated by the section A and the section B.
9. The method of claim 8, wherein the film of step (5) is cured and then a layer of calcium stearate powder is sprayed into the whole calcium chloride material.
10. The method for preparing the rapid and long-acting postpartum calcium supplement preparation for dairy cows according to claim 8, wherein in the step (1) and the step (2), the temperature of heating and melting is 80-85 ℃; in the step (4) and the step (5), the temperature of the coating is 90-95 ℃.
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| CN202310417331.4A CN116349787A (en) | 2023-04-19 | 2023-04-19 | Milk cow postpartum fast and long-acting calcium supplementing preparation and preparation method thereof |
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| US20070190116A1 (en) * | 2005-11-01 | 2007-08-16 | Rigel Technology Corporation | Solid calcium bolus product with quick dissolution |
| EP2676657A1 (en) * | 2012-06-22 | 2013-12-25 | Laboratoires Aditec | Composition for the treatment of hypocalcaemia in ruminants |
| CN108553483A (en) * | 2018-06-21 | 2018-09-21 | 王允瑞 | A kind of ox sustained release calcium and preparation method thereof |
| CN110368369A (en) * | 2019-08-30 | 2019-10-25 | 广州新济药业科技有限公司 | Calcium complement agent and preparation method thereof |
| CN113693166A (en) * | 2021-08-19 | 2021-11-26 | 浙江万方生物科技有限公司 | Sectional type slow-release mineral element rod special for dairy cows and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070190116A1 (en) * | 2005-11-01 | 2007-08-16 | Rigel Technology Corporation | Solid calcium bolus product with quick dissolution |
| EP2676657A1 (en) * | 2012-06-22 | 2013-12-25 | Laboratoires Aditec | Composition for the treatment of hypocalcaemia in ruminants |
| CN108553483A (en) * | 2018-06-21 | 2018-09-21 | 王允瑞 | A kind of ox sustained release calcium and preparation method thereof |
| CN110368369A (en) * | 2019-08-30 | 2019-10-25 | 广州新济药业科技有限公司 | Calcium complement agent and preparation method thereof |
| CN113693166A (en) * | 2021-08-19 | 2021-11-26 | 浙江万方生物科技有限公司 | Sectional type slow-release mineral element rod special for dairy cows and preparation method thereof |
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