CN111449171A - Rumen-protected multivitamin preparation and preparation method and application thereof - Google Patents
Rumen-protected multivitamin preparation and preparation method and application thereof Download PDFInfo
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- CN111449171A CN111449171A CN202010385178.8A CN202010385178A CN111449171A CN 111449171 A CN111449171 A CN 111449171A CN 202010385178 A CN202010385178 A CN 202010385178A CN 111449171 A CN111449171 A CN 111449171A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 83
- 210000004767 rumen Anatomy 0.000 claims abstract description 35
- 229940088594 vitamin Drugs 0.000 claims abstract description 31
- 229930003231 vitamin Natural products 0.000 claims abstract description 31
- 235000013343 vitamin Nutrition 0.000 claims abstract description 31
- 239000011782 vitamin Substances 0.000 claims abstract description 31
- 241000282849 Ruminantia Species 0.000 claims abstract description 25
- 239000000463 material Substances 0.000 claims abstract description 25
- 238000006243 chemical reaction Methods 0.000 claims abstract description 24
- -1 compound vitamin Chemical class 0.000 claims abstract description 14
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 12
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims abstract description 12
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 12
- 235000019155 vitamin A Nutrition 0.000 claims abstract description 12
- 239000011719 vitamin A Substances 0.000 claims abstract description 12
- 229940045997 vitamin a Drugs 0.000 claims abstract description 12
- 150000002148 esters Chemical class 0.000 claims abstract description 8
- 239000002270 dispersing agent Substances 0.000 claims abstract description 7
- 238000010438 heat treatment Methods 0.000 claims description 44
- 239000000203 mixture Substances 0.000 claims description 39
- PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 claims description 34
- 235000014443 Pyrus communis Nutrition 0.000 claims description 33
- 238000001816 cooling Methods 0.000 claims description 33
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 26
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 22
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 22
- 238000002156 mixing Methods 0.000 claims description 22
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 20
- 229960001947 tripalmitin Drugs 0.000 claims description 17
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 16
- 239000000377 silicon dioxide Substances 0.000 claims description 13
- 235000012239 silicon dioxide Nutrition 0.000 claims description 12
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 11
- 229930003268 Vitamin C Natural products 0.000 claims description 11
- 229930003448 Vitamin K Natural products 0.000 claims description 11
- 235000020958 biotin Nutrition 0.000 claims description 11
- 239000011616 biotin Substances 0.000 claims description 11
- 229960002685 biotin Drugs 0.000 claims description 11
- 238000004806 packaging method and process Methods 0.000 claims description 11
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 11
- 235000019156 vitamin B Nutrition 0.000 claims description 11
- 239000011720 vitamin B Substances 0.000 claims description 11
- 235000019154 vitamin C Nutrition 0.000 claims description 11
- 239000011718 vitamin C Substances 0.000 claims description 11
- 239000011712 vitamin K Substances 0.000 claims description 11
- 235000019168 vitamin K Nutrition 0.000 claims description 11
- 150000003721 vitamin K derivatives Chemical class 0.000 claims description 11
- 229940046010 vitamin k Drugs 0.000 claims description 11
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 10
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 10
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 10
- 229960002079 calcium pantothenate Drugs 0.000 claims description 10
- 229960000304 folic acid Drugs 0.000 claims description 10
- 235000019152 folic acid Nutrition 0.000 claims description 10
- 239000011724 folic acid Substances 0.000 claims description 10
- 239000000654 additive Substances 0.000 claims description 5
- 230000000996 additive effect Effects 0.000 claims description 5
- 239000003674 animal food additive Substances 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 6
- 238000000034 method Methods 0.000 claims 3
- 150000003722 vitamin derivatives Chemical class 0.000 abstract description 11
- 239000000126 substance Substances 0.000 abstract description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 3
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 238000000576 coating method Methods 0.000 description 14
- 239000011248 coating agent Substances 0.000 description 11
- 238000010521 absorption reaction Methods 0.000 description 10
- 238000004090 dissolution Methods 0.000 description 8
- 239000003921 oil Substances 0.000 description 8
- 239000000843 powder Substances 0.000 description 8
- 210000000813 small intestine Anatomy 0.000 description 8
- 239000004925 Acrylic resin Substances 0.000 description 5
- 229920000178 Acrylic resin Polymers 0.000 description 5
- 239000001856 Ethyl cellulose Substances 0.000 description 5
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 5
- 229920001249 ethyl cellulose Polymers 0.000 description 5
- 235000019325 ethyl cellulose Nutrition 0.000 description 5
- 235000015097 nutrients Nutrition 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 239000011162 core material Substances 0.000 description 2
- 239000012628 flowing agent Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 206010057040 Temperature intolerance Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000008543 heat sensitivity Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000015816 nutrient absorption Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000020939 nutritional additive Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
Abstract
The invention belongs to the technical field of rumen-bypass protection of vitamin substances of ruminants, and particularly relates to a rumen-bypass compound vitamin preparation as well as a preparation method and application thereof, wherein the rumen-bypass compound vitamin preparation comprises A, B, C, D four components; the component A is a compound vitamin at least containing vitamin A, D, E; the component B is an edible ester auxiliary material; the component C is an edible alcohol auxiliary material; the component D is a dispersant; the weight ratio of the component A to the component B to the component C to the component D is (9-11) to (8-10) to (0.5-2) to 1. The invention enables the vitamin active ingredients for the ruminants to smoothly enter the intestinal tract and be absorbed and utilized by the ruminants by adding the rumen bypass material auxiliary materials, promotes the growth of the ruminants and simultaneously improves the feed conversion rate.
Description
Technical Field
The invention belongs to the technical field of rumen protection of vitamin substances of ruminants such as cattle and sheep, and particularly relates to a rumen-protected compound vitamin preparation as well as a preparation method and application thereof.
Background
Due to the particularity of the stomach structure of the ruminant, the vitamins are nutritional additives which need to be supplemented when the ruminant is fed, so that the nutrient absorption in the feed can be promoted, and the vitamins can play a good role in promoting the growth of the body of the ruminant and resisting diseases. However, these nutritional supplements are inactivated in the rumen of ruminants due to their high heat sensitivity, and thus have a reduced titer, and thus do not play a desirable role.
Most of the rumen bypass vitamins used at present use vitamins as core materials, ethyl cellulose and acrylic resin as wall materials, and ethyl cellulose and acrylic resin are dissolved by using ethanol as a solvent and coated in a spraying state. The coating wall material is about 1-2%, the coating process consumes time and energy, the organic solvent is used to pollute the environment, the batch quantity is small, the batch quantity is about 100kg, and the coating is not suitable for feed production and application.
Therefore, the ruminant breeding industry needs to provide a rumen-bypass multivitamin preparation which can simultaneously provide multiple multivitamin nutrients, does not pollute the environment, can be produced in batches, can promote the absorption of the nutrients in the feed, improves the utilization rate of the feed and has high utilization rate of the added nutrients.
Disclosure of Invention
The invention aims to solve the problems of single effective vitamin component and poor using effect in the existing ruminant feed, thereby providing a rumen-bypass compound vitamin preparation which can promote the absorption of nutrient substances in the feed, improve the utilization rate of the feed and promote the growth of the ruminant, and a preparation method and application thereof.
The technical scheme adopted by the invention is as follows:
a rumen-protected complex vitamin preparation comprises A, B, C, D four components; the component A is a compound vitamin at least containing vitamin A, D, E; the component B is an edible ester auxiliary material; the component C is an edible alcohol auxiliary material; the component D is a dispersant; the weight ratio of the component A to the component B to the component C to the component D is (9-11) to (8-10) to (0.5-2) to 1.
Preferably, the vitamin complex further comprises at least one of water-soluble B vitamins, vitamin K, vitamin C, nicotinamide, biotin, calcium pantothenate and folic acid.
Preferably, the edible ester auxiliary material is tripalmitin.
Preferably, the edible alcohol auxiliary material is polyethylene glycol 6000.
Preferably, the dispersant is silica.
Preferably, the weight ratio of the component A, the component B, the component C and the component D is 10: B: C: D: 10: 1.
A preparation method of a rumen-protected multivitamin preparation comprises the following steps:
step 1): preparing a component A, a component B, a component C and a component D according to a set proportion;
step 2): uniformly mixing the component A, the component B and the component C prepared in the step 1), putting the mixture into a heating reaction kettle, selecting a 500-liter heating reaction kettle, heating to more than 70 ℃, stirring and heating to about 80 ℃ for later use;
step 3): adding the component D prepared in the step 1) into a pear cutter mixer;
step 4): starting a pear knife mixer, putting the mixture obtained in the step 2) into the pear knife mixer, uniformly mixing the mixture with the component D, and naturally cooling for 20-30 minutes to obtain the finished rumen-protected multivitamin preparation.
Preferably, the preparation method of the rumen-protected multivitamin preparation further comprises the following steps:
step 5): and (3) placing the rumen-protected multivitamin preparation prepared in the step 4) in an induced air cooling cabin, cooling to normal temperature, and packaging.
A rumen-bypass compound vitamin preparation is used as ruminant feed additive.
Preferably, the additive accounts for 5% of the weight of the ruminant feed.
The invention has the beneficial effects that:
1. through the interaction of the ester auxiliary materials, the alcohol auxiliary materials and the flowing agent, a layer of coating can be formed on the outer surface of the compound vitamin, so that the compound vitamin can smoothly enter the intestinal tract of the ruminant and is absorbed and utilized by the ruminant, the growth of the ruminant is promoted, and meanwhile, the feed conversion rate can be improved.
2. The tripalmitin and the polyethylene glycol 6000 are coating materials and can provide coatings for the multivitamins, so that the multivitamins can smoothly pass through the rumens of the ruminants, the ruminants can smoothly absorb nutrition, the silicon dioxide plays a role of a flowing agent, the multivitamins can be prevented from caking, and the multivitamins can be further promoted to smoothly pass through the rumens of the ruminants.
3. The tripalmitin and the polynonsaccharide 6000 form the coating multivitamin, so that the active and nutrient substances can be well reserved and directly enter the intestinal tract of the ruminant, the function of the composite vitamin is similar to that of a monogastric animal, and the effect is obvious.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Most of rumen bypass vitamins currently used in the market are prepared by taking vitamins as core materials and ethyl cellulose and acrylic resin as wall materials, dissolving the ethyl cellulose and the acrylic resin by taking ethanol as a solvent, and coating the dissolved ethyl cellulose and the acrylic resin in a spraying state. The coating wall material is about 1-2%, the coating process consumes time and energy, the organic solvent is used to pollute the environment, the batch quantity is small, the batch quantity is about 100kg, and the coating is not suitable for feed production and application.
Therefore, the invention provides a rumen-protected multivitamin preparation as well as a preparation method and application thereof, and the technical scheme is as follows:
a rumen-protected complex vitamin preparation comprises A, B, C, D four components; the component A is a compound vitamin at least containing vitamin A, D, E; the component B is an edible ester auxiliary material; the component C is an edible alcohol auxiliary material; the component D is a dispersant; the weight ratio of the component A to the component B to the component C to the component D is (9-11) to (8-10) to (0.5-2) to 1. The compound vitamin also comprises at least one of water-soluble B vitamins, vitamin K, vitamin C, nicotinamide, biotin, calcium pantothenate and folic acid. The edible ester auxiliary material is tripalmitin. The edible alcohol adjuvant is polyethylene glycol 6000. The dispersing agent is silicon dioxide. The weight ratio of the component A, the component B, the component C and the component D is 10: 1.
A preparation method of a rumen-protected multivitamin preparation comprises the following steps:
step 1): preparing a component A, a component B, a component C and a component D according to a set proportion;
step 2): uniformly mixing the component A, the component B and the component C prepared in the step 1), putting the mixture into a heating reaction kettle, selecting a 500-liter heating reaction kettle, heating to more than 70 ℃, stirring and heating to about 80 ℃ for later use;
step 3): adding the component D prepared in the step 1) into a pear cutter mixer;
step 4): starting a pear knife mixer, putting the mixture obtained in the step 2) into the pear knife mixer, uniformly mixing the mixture with the component D, and naturally cooling for 20-30 minutes to obtain the finished rumen-protected multivitamin preparation.
Preferably, the preparation method of the rumen-protected multivitamin preparation further comprises the following steps:
step 5): and (3) placing the rumen-protected multivitamin preparation prepared in the step 4) in an induced air cooling cabin, cooling to normal temperature, and packaging.
A rumen-bypass compound vitamin preparation is used as ruminant feed additive.
Preferably, the additive accounts for 5% of the weight of the ruminant feed.
In the invention, only tripalmitin or polyethylene glycol 6000 is selected as the coating of the multivitamin, but because tripalmitin has a low melting point and is easy to agglomerate in summer, and a proper amount of polyethylene glycol 6000 is added, the tripalmitin is not easy to agglomerate after granulation. Polyethylene glycol 6000 has certain water solubility and is easy to dissolve in rumen. The properties of the two materials are combined, and the mixed coating material is selected, so that the effect is better.
The invention will now be further illustrated with reference to specific examples.
Example 1, a rumen bypass multivitamin preparation comprising A, B, C, D four components was prepared in a weight ratio of 9: 8: 0.5: 1.
Wherein the component A comprises vitamin A, D, E, water-soluble B vitamins, vitamin K, vitamin C, nicotinamide and biotin, and the total amount is 90 kg;
the component B is tripalmitin accounting for 80 kg;
the component C is 5kg of polyethylene glycol 6000;
the component D is silicon dioxide (the oil absorption value of the blow-dry powder is more than 3), and the total weight is 10 kg;
the preparation method of the rumen-protected multivitamin preparation comprises the following steps:
step 1): preparing a component A, a component B, a component C and a component D according to a set proportion;
step 2): uniformly mixing the component A, the component B and the component C prepared in the step 1), putting the mixture into a heating reaction kettle, selecting a 500-liter heating reaction kettle, heating to more than 70 ℃, stirring and heating to about 80 ℃ for later use;
step 3): adding the component D prepared in the step 1) into a pear cutter mixer;
step 4): starting a pear knife mixer, putting the mixture obtained in the step 2) into the pear knife mixer, uniformly mixing the mixture with the component D, and naturally cooling for 20 minutes to obtain the finished rumen-protected multivitamin preparation.
Step 5): and (3) placing the rumen-protected multivitamin preparation prepared in the step 4) in an induced air cooling cabin, cooling to normal temperature, and packaging.
The rumen bypass multivitamin preparation prepared by the embodiment has a rumen bypass rate of 80% and a dissolution rate of 90% in small intestine.
Example 2, a rumen-protected multivitamin preparation comprising A, B, C, D four components was prepared in a weight ratio of 9: 10: 2: 1.
Wherein the component A comprises vitamin A, D, E, water-soluble B vitamins, vitamin K, vitamin C, nicotinamide, biotin, calcium pantothenate and folic acid, and the total amount is 90 kg;
the component B is tripalmitin accounting for 100 kg;
the component C is 20kg of polyethylene glycol 6000;
the component D is silicon dioxide (the oil absorption value of the blow-dry powder is more than 3), and the total weight is 10 kg;
the preparation method of the rumen-protected multivitamin preparation comprises the following steps:
step 1): preparing a component A, a component B, a component C and a component D according to a set proportion;
step 2): uniformly mixing the component A, the component B and the component C prepared in the step 1), putting the mixture into a heating reaction kettle, selecting a 500-liter heating reaction kettle, heating to more than 70 ℃, stirring and heating to about 80 ℃ for later use;
step 3): adding the component D prepared in the step 1) into a pear cutter mixer;
step 4): starting a pear knife mixer, putting the mixture obtained in the step 2) into the pear knife mixer, uniformly mixing the mixture with the component D, and naturally cooling for 25 minutes to obtain the finished rumen-protected multivitamin preparation.
Step 5): and (3) placing the rumen-protected multivitamin preparation prepared in the step 4) in an induced air cooling cabin, cooling to normal temperature, and packaging.
The rumen bypass multivitamin preparation prepared in the embodiment has a rumen bypass rate of 82% and a dissolution rate of 88% in small intestine.
Example 3, a rumen bypass multivitamin preparation comprising A, B, C, D four components was prepared in a weight ratio of 11: 8: 0.5: 1.
Wherein the component A consists of vitamin A, D, E, water-soluble B vitamins, vitamin K, vitamin C, nicotinamide, biotin, calcium pantothenate and folic acid, and the total amount is 110 kg;
the component B is tripalmitin accounting for 80 kg;
the component C is 5kg of polyethylene glycol 6000;
the component D is silicon dioxide (the oil absorption value of the blow-dry powder is more than 3), and the total weight is 10 kg;
the preparation method of the rumen-protected multivitamin preparation comprises the following steps:
step 1): preparing a component A, a component B, a component C and a component D according to a set proportion;
step 2): uniformly mixing the component A, the component B and the component C prepared in the step 1), putting the mixture into a heating reaction kettle, selecting a 500-liter heating reaction kettle, heating to more than 70 ℃, stirring and heating to about 80 ℃ for later use;
step 3): adding the component D prepared in the step 1) into a pear cutter mixer;
step 4): starting a pear knife mixer, putting the mixture obtained in the step 2) into the pear knife mixer, uniformly mixing the mixture with the component D, and naturally cooling for 30 minutes to obtain the finished rumen-protected multivitamin preparation.
Step 5): and (3) placing the rumen-protected multivitamin preparation prepared in the step 4) in an induced air cooling cabin, cooling to normal temperature, and packaging.
The rumen bypass multivitamin preparation prepared in the embodiment has a rumen bypass rate of 88% and a dissolution rate of 92% in small intestine.
Example 4, a rumen bypass multivitamin preparation comprising A, B, C, D four components, prepared in a weight ratio of 11: 10: 2: 1.
Wherein the component A consists of vitamin A, D, E, water-soluble B vitamins, vitamin K, vitamin C, nicotinamide, biotin, calcium pantothenate and folic acid, and the total amount is 110 kg;
the component B is tripalmitin accounting for 100 kg;
the component C is 20kg of polyethylene glycol 6000;
the component D is silicon dioxide (the oil absorption value of the blow-dry powder is more than 3), and the total weight is 10 kg;
the preparation method of the rumen-protected multivitamin preparation comprises the following steps:
step 1): preparing a component A, a component B, a component C and a component D according to a set proportion;
step 2): uniformly mixing the component A, the component B and the component C prepared in the step 1), putting the mixture into a heating reaction kettle, selecting a 500-liter heating reaction kettle, heating to more than 70 ℃, stirring and heating to about 80 ℃ for later use;
step 3): adding the component D prepared in the step 1) into a pear cutter mixer;
step 4): starting a pear knife mixer, putting the mixture obtained in the step 2) into the pear knife mixer, uniformly mixing the mixture with the component D, and naturally cooling for 30 minutes to obtain the finished rumen-protected multivitamin preparation.
Step 5): and (3) placing the rumen-protected multivitamin preparation prepared in the step 4) in an induced air cooling cabin, cooling to normal temperature, and packaging.
The rumen bypass multivitamin preparation prepared in the embodiment has a rumen bypass rate of 85% and a dissolution rate of 86% in small intestine.
Example 5, a rumen-protected multivitamin preparation comprising A, B, C, D four components was prepared in a weight ratio of 10: 9: 1.
Wherein the component A consists of vitamin A, D, E, water-soluble B vitamins, vitamin K, vitamin C, nicotinamide, biotin, calcium pantothenate and folic acid, and the total amount is 100 kg;
the component B is tripalmitin accounting for 90 kg;
the component C is 10kg of polyethylene glycol 6000;
the component D is silicon dioxide (the oil absorption value of the blow-dry powder is more than 3), and the total weight is 10 kg;
the preparation method of the rumen-protected multivitamin preparation comprises the following steps:
step 1): preparing a component A, a component B, a component C and a component D according to a set proportion;
step 2): uniformly mixing the component A, the component B and the component C prepared in the step 1), putting the mixture into a heating reaction kettle, selecting a 500-liter heating reaction kettle, heating to more than 70 ℃, stirring and heating to about 80 ℃ for later use;
step 3): adding the component D prepared in the step 1) into a pear cutter mixer;
step 4): starting a pear knife mixer, putting the mixture obtained in the step 2) into the pear knife mixer, uniformly mixing the mixture with the component D, and naturally cooling for 30 minutes to obtain the finished rumen-protected multivitamin preparation.
Step 5): and (3) placing the rumen-protected multivitamin preparation prepared in the step 4) in an induced air cooling cabin, cooling to normal temperature, and packaging.
The rumen bypass multivitamin preparation prepared by the embodiment has a rumen bypass rate of 90% and a dissolution rate of 95% in small intestine.
Example 6, a rumen-protected multivitamin preparation comprising A, B, C, D four components was prepared in a weight ratio of 10: 1.
Wherein the component A consists of vitamin A, D, E, water-soluble B vitamins, vitamin K, vitamin C, nicotinamide, biotin, calcium pantothenate and folic acid, and the total amount is 100 kg;
the component B is tripalmitin accounting for 100 kg;
the component C is 10kg of polyethylene glycol 6000;
the component D is silicon dioxide (the oil absorption value of the blow-dry powder is more than 3), and the total weight is 10 kg;
the preparation method of the rumen-protected multivitamin preparation comprises the following steps:
step 1): preparing a component A, a component B, a component C and a component D according to a set proportion;
step 2): uniformly mixing the component A, the component B and the component C prepared in the step 1), putting the mixture into a heating reaction kettle, selecting a 500-liter heating reaction kettle, heating to more than 70 ℃, stirring and heating to about 80 ℃ for later use;
step 3): adding the component D prepared in the step 1) into a pear cutter mixer;
step 4): starting a pear knife mixer, putting the mixture obtained in the step 2) into the pear knife mixer, uniformly mixing the mixture with the component D, and naturally cooling for 25 minutes to obtain the finished rumen-protected multivitamin preparation.
Step 5): and (3) placing the rumen-protected multivitamin preparation prepared in the step 4) in an induced air cooling cabin, cooling to normal temperature, and packaging.
The rumen bypass multivitamin preparation prepared by the embodiment has a rumen bypass rate of 95% and a dissolution rate of 98% in small intestine.
Example 7, a rumen bypass multivitamin preparation comprising A, B, C, D four components, prepared in a weight ratio of 10: 8: 2: 1.
Wherein the component A consists of vitamin A, D, E, water-soluble B vitamins, vitamin K, vitamin C, nicotinamide, biotin, calcium pantothenate and folic acid, and the total amount is 100 kg;
the component B is tripalmitin accounting for 80 kg;
the component C is 20kg of polyethylene glycol 6000;
the component D is silicon dioxide (the oil absorption value of the blow-dry powder is more than 3), and the total weight is 10 kg;
the preparation method of the rumen-protected multivitamin preparation comprises the following steps:
step 1): preparing a component A, a component B, a component C and a component D according to a set proportion;
step 2): uniformly mixing the component A, the component B and the component C prepared in the step 1), putting the mixture into a heating reaction kettle, selecting a 500-liter heating reaction kettle, heating to more than 70 ℃, stirring and heating to about 80 ℃ for later use;
step 3): adding the component D prepared in the step 1) into a pear cutter mixer;
step 4): starting a pear knife mixer, putting the mixture obtained in the step 2) into the pear knife mixer, uniformly mixing the mixture with the component D, and naturally cooling for 30 minutes to obtain the finished rumen-protected multivitamin preparation.
Step 5): and (3) placing the rumen-protected multivitamin preparation prepared in the step 4) in an induced air cooling cabin, cooling to normal temperature, and packaging.
The rumen bypass multivitamin preparation prepared by the embodiment has a rumen bypass rate of 86% and a dissolution rate of 90% in small intestine.
Example 8, a rumen bypass multivitamin preparation comprising A, B, C, D four components, prepared in a weight ratio of 11: 9: 1.
Wherein the component A consists of vitamin A, D, E, water-soluble B vitamins, vitamin K, vitamin C, nicotinamide, biotin, calcium pantothenate and folic acid, and the total amount is 110 kg;
the component B is tripalmitin accounting for 90 kg;
the component C is 10kg of polyethylene glycol 6000;
the component D is silicon dioxide (the oil absorption value of the blow-dry powder is more than 3), and the total weight is 10 kg;
the preparation method of the rumen-protected multivitamin preparation comprises the following steps:
step 1): preparing a component A, a component B, a component C and a component D according to a set proportion;
step 2): uniformly mixing the component A, the component B and the component C prepared in the step 1), putting the mixture into a heating reaction kettle, selecting a 500-liter heating reaction kettle, heating to more than 70 ℃, stirring and heating to about 80 ℃ for later use;
step 3): adding the component D prepared in the step 1) into a pear cutter mixer;
step 4): starting a pear knife mixer, putting the mixture obtained in the step 2) into the pear knife mixer, uniformly mixing the mixture with the component D, and naturally cooling for 30 minutes to obtain the finished rumen-protected multivitamin preparation.
Step 5): and (3) placing the rumen-protected multivitamin preparation prepared in the step 4) in an induced air cooling cabin, cooling to normal temperature, and packaging.
The rumen bypass multivitamin preparation prepared by the embodiment has a rumen bypass rate of 90% and a dissolution rate of 92% in small intestine.
In summary, the present invention can produce the products with the batch size of 100-.
Wherein the technical parameters of rumen-bypass multivitamins are met: the product is not dissolved after being placed in water solution for 12 hours when the pH value is less than 6; the product can be dissolved in water solution at pH > 7 for 2 hr, and in the present invention, tripalmitin and polyethylene glycol 6000 are used as coating materials to provide a coating layer on the vitamin complex, and silicon dioxide is used as flow agent.
The additive to various components carries out organic integration in this scheme for the addition is scientific, and is standard, in the use simplification, the conventionalization, the result of use is ideal, through the capsule peridium, can guarantee its activity of vitamin, the valence is stable, compared in prior art, the conventional processing technology of this scheme, the difficult problem of easy oxidation yielding substance additive deactivation has been successfully solved, the built-up materials science, multiple vitamin active ingredient has the synergism in the feed addition, can improve the result of use, reduction in production cost and use cost, there is fine market prospect.
Finally, it should be noted that: the above embodiments are only used for illustrating the technical solutions of the present application, and not for limiting the same; although the present application has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present application.
Claims (10)
1. A rumen-protected multivitamin preparation, which is characterized in that: a, B, C, D comprises four components; the component A is a compound vitamin at least containing vitamin A, D, E; the component B is an edible ester auxiliary material; the component C is an edible alcohol auxiliary material; the component D is a dispersant; the weight ratio of the component A to the component B to the component C to the component D is (9-11) to (8-10) to (0.5-2) to 1.
2. The rumen bypass multivitamin formulation according to claim 1, wherein: the compound vitamin also comprises at least one of water-soluble B vitamins, vitamin K, vitamin C, nicotinamide, biotin, calcium pantothenate and folic acid.
3. The rumen bypass multivitamin formulation according to claim 1, wherein: the edible ester auxiliary material is tripalmitin.
4. The rumen bypass multivitamin formulation according to claim 1, wherein: the edible alcohol adjuvant is polyethylene glycol 6000.
5. The rumen bypass multivitamin formulation according to claim 1, wherein: the dispersing agent is silicon dioxide.
6. The rumen bypass multivitamin formulation according to claim 1, wherein: the weight ratio of the component A, the component B, the component C and the component D is 10: 1.
7. The method for preparing a rumen-protected multivitamin preparation according to claim 1, wherein the method comprises the following steps:
step 1): preparing a component A, a component B, a component C and a component D according to a set proportion;
step 2): uniformly mixing the component A, the component B and the component C prepared in the step 1), putting the mixture into a heating reaction kettle, selecting a 500-liter heating reaction kettle, heating to more than 70 ℃, stirring and heating to about 80 ℃ for later use;
step 3): adding the component D prepared in the step 1) into a pear cutter mixer;
step 4): starting a pear knife mixer, putting the mixture obtained in the step 2) into the pear knife mixer, uniformly mixing the mixture with the component D, and naturally cooling for 20-30 minutes to obtain the finished rumen-protected multivitamin preparation.
8. The method for preparing a rumen-protected multivitamin preparation according to claim 7, wherein: the step 4) is followed by:
step 5): and (3) placing the rumen-protected multivitamin preparation prepared in the step 4) in an induced air cooling cabin, cooling to normal temperature, and packaging.
9. The use of a rumen bypass multivitamin formulation as claimed in claim 1 as a feed additive for ruminants.
10. Use according to claim 9, characterized in that: the additive accounts for 5 percent of the weight of the ruminant feed.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112006171A (en) * | 2020-09-03 | 2020-12-01 | 安徽东方天合生物技术有限责任公司 | Novel rumen-bypass compound vitamin coating process |
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Application publication date: 20200728 |