CN102125168B - Preparation method of gamma-aminobutyric acid coated when passing rumen - Google Patents
Preparation method of gamma-aminobutyric acid coated when passing rumen Download PDFInfo
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- CN102125168B CN102125168B CN2010100396301A CN201010039630A CN102125168B CN 102125168 B CN102125168 B CN 102125168B CN 2010100396301 A CN2010100396301 A CN 2010100396301A CN 201010039630 A CN201010039630 A CN 201010039630A CN 102125168 B CN102125168 B CN 102125168B
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Abstract
The invention relates to a preparation method of an animal feed additive gamma-aminobutyric acid coated when passing a rumen. The animal feed additive gamma-aminobutyric acid coated when passing the rumen comprises the following components in percentage by weight: 5%-20% of starches, 5%-10% of hydroxy propyl methyl celluloses, 50%-80% of gamma-aminobutyric acid powder, 5%-15% of glycerol stearate and 3%-5% of resins 2#. The preparation method enables the gamma-aminobutyric acid powder not to be fermented and degraded when passing the rumen of a ruminant and to be released in a long-acting way in intestinal tracts by carrying out microencapsulating coating processing on the gamma-aminobutyric acid powder, and enhances the effective absorption and utilization of the gamma-aminobutyric acid powder in the intestinal tracts, thereby enabling the physiological functions to be sufficiently played in the ruminant.
Description
Technical field
Patent of the present invention relates to a kind of preparation method who crosses cud coating GABA for animal feed additive.
Background technology
The distresses such as along with the raising of global warming aggravation and cultivation intensive degree, the production ox is suffering the challenge of severe thermal environment, has occurred reducing such as appetite decline, feed intake, and production capacity descends, resistance against diseases weakens react.In order to increase the economic benefit of milk, beef cattle cultivation, extensively adopted early weaned technology both at home and abroad, but early weaning also a series of distresses reactions such as appetite reduction, feed intake minimizing, digestion and metabolism disorder, immunity reduction, diarrhoea, poor growth even death have been brought to calf simultaneously.Therefore, how overcoming the reaction such as the distress of producing ox heat stress and calf ablactation stress, is the bottleneck problem during current cattle-raising is produced.The means that solve at present the ruminant distress be mainly strengthen feeding and management and add various anti-stress additive etc., and strengthen feeding and management to improve effect limited, directly add external source anti-stress the additive effect also not remarkable, very easily by ruminant tumor gastric microbial fermentation, degraded, be difficult to be utilized by animal and bring into play its anti-stress effect.Therefore, seeking novel, safe and effective resisting stress additive be the task of top priority of present cattle-raising.
GABA is the seed amino acids that animals and plants circle extensively distribute, and is inhibitory neurotransmitter important in the mammalian central nervous system, having calmly to calm the nerves, promotes appetite, resist and stress wait physiological function.According to reported in literature, GABA is remarkable to alleviating the various distress reaction effects of growing-finishing pig, milking sow, weanling pig and bird.Therefore, GABA is as a kind of safe and effective anti-stress being widely used in the Production of Livestock and Poultry by additive.But because GABA is easily by ruminant tumor gastric microbial degradation, thereby limited greatly its application in ruminant.
The invention provides a kind of preparation method who crosses cud coating GABA, process by GABA being carried out microencapsulated coating, be not fermented when making it by ruminant tumor gastric, degrade, long-acting release in enteron aisle, increase its effectively absorbing in enteron aisle, its physiological function is not fully exerted.
Summary of the invention
The object of the present invention is achieved like this: a kind of production method of crossing cud coating gamma-aminobutyric acid preparation is characterized in that it forms (calculating by mass percentage) by following material:
Starch 5-20%
HPMC 5-10%
GABA powder 50-80%
Tristerin 5-15%
Resin 2# 3-5%
Embodiments of the present invention are as follows: a kind of preparation method who crosses cud coating GABA is characterized in that first GABA powder with the starch of 5-20%, 50-80% under the 30-90rpm rotating speed, stirs 10-40min and mixes; The HPMC that takes by weighing 5-10% is dissolved in the water, and obtains the HPMC solution of 5-10%, and above HPMC solution is joined in starch and the GABA mixture, oscillating granulation, draw air-dry dry, EAT 40-80 ℃, leaving air temp normal temperature; Take by weighing tristerin (5-15%) and resin 2# (3-5%), join fully dissolving in an amount of ethanolic solution, as coating liquid; In encapsulation tool with flow velocity 0.05-3L/min, EAT 40-80 ℃, leaving air temp normal temperature, time 3-4h carries out coating and processes.Product granularity is crossed 20 mesh sieves more than 85%.
Main feature of the present invention is: GABA is carried out microencapsulated coating process, GABA behind the coating is in the micro-capsule packaging material, avoid ruminant tumor gastric to fermentation, the degraded of GABA, realize that GABA passes through cud smoothly, long-acting slow-release in ruminant body enteron aisle, improve ruminant to the bioavailability of GABA, the physiological function of GABA is not fully exerted in ruminant produces.
Description of drawings
Fig. 1 is processing process figure of the present invention
Fig. 2 is the equipment schematic diagram that the present invention uses
The specific embodiment
Embodiment 1
Take by weighing starch 500g, GABA powder 8000g under the 30-90rpm rotating speed, stirs 20min and mixes; Take by weighing the 500g HPMC and be dissolved in the 10000mL water, obtain 5% HPMC solution, above HPMC solution is joined in starch and the GABA mixture, oscillating granulation, draw air-dry dry, EAT 50-60 ℃, leaving air temp normal temperature; Take by weighing tristerin 500g and resin 2#500g, join fully dissolving in the 21000mL ethanolic solution, as coating liquid; In encapsulation tool with flow velocity 0.1L/min, EAT 50-60 ℃, leaving air temp normal temperature, time 3.5h carries out coating and processes.Product granularity is crossed 20 mesh sieves more than 85%.
Embodiment 2
Take by weighing starch 2000g, GABA powder 5000g under the 30-90rpm rotating speed, stirs 20min and mixes; Take by weighing the 1000g HPMC and be dissolved in the 10000mL water, obtain 10% HPMC solution, above HPMC solution is joined in starch and the GABA mixture, oscillating granulation, draw air-dry dry, EAT 50-60 ℃, leaving air temp normal temperature; Take by weighing tristerin 1500g and resin 2#500g, join fully dissolving in the 21000mL ethanolic solution, as coating liquid; In encapsulation tool with flow velocity 0.1L/min, EAT 50-60 ℃, leaving air temp normal temperature, time 3.5h carries out coating and processes.Product granularity is crossed 20 mesh sieves more than 85%.
Claims (6)
1. preparation method who crosses cud coating GABA is characterized in that it is comprised of following material, counts by weight percentage:
Starch, GABA powder under the 30-90rpm rotating speed, are stirred 10-40min and mix; The HPMC that takes by weighing 5-10% is dissolved in the water, and obtains the HPMC solution of 5-10%, and above HPMC solution is joined in starch and the GABA mixture, oscillating granulation, draw air-dry dryly, EAT 40-80 ℃, leaving air temp is normal temperature; Take by weighing tristerin and resin 2#, join fully dissolving in an amount of ethanolic solution, as coating liquid; In encapsulation tool with flow velocity 0.05-3L/min, EAT 40-80 ℃, leaving air temp normal temperature, time 3-4h carries out coating and processes; Product granularity is crossed 20 mesh sieves more than 85%.
2. the preparation method who crosses cud coating GABA according to claim 1 is characterized in that the GABA powder is feed grade.
3. the preparation method of excessively cud coating GABA according to claim 1 is characterized in that its alpha-aminobutyric acid content of excessively cud coating gamma-aminobutyric acid preparation that obtains is 50-80%.
4. the preparation method who crosses cud coating GABA according to claim 1 is characterized in that coated fertilizer is HPMC, tristerin and resin 2#.
5. the preparation method who crosses cud coating GABA according to claim 1 is characterized in that the GABA powder is the Ultramicro-powder pulverized powder, and granularity is the 100-150 order.
6. the preparation method who crosses cud coating GABA according to claim 1 is characterized in that preparing ruminant feed or feed addictive.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010100396301A CN102125168B (en) | 2010-01-12 | 2010-01-12 | Preparation method of gamma-aminobutyric acid coated when passing rumen |
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| CN2010100396301A CN102125168B (en) | 2010-01-12 | 2010-01-12 | Preparation method of gamma-aminobutyric acid coated when passing rumen |
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| CN102125168A CN102125168A (en) | 2011-07-20 |
| CN102125168B true CN102125168B (en) | 2013-04-03 |
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| JP6740550B2 (en) * | 2015-10-13 | 2020-08-19 | 地方独立行政法人青森県産業技術センター | Edible microcapsules, method for producing edible microcapsules, and seasoning |
| CN107712319A (en) * | 2017-09-25 | 2018-02-23 | 张自力 | A kind of ruminant animal nutrition functional feedstuff additive and its production technology |
| CN107594227A (en) * | 2017-10-30 | 2018-01-19 | 农博士（福建）生物技术有限公司 | Fish feed, feed addictive and preparation method thereof |
| CN107751547A (en) * | 2017-10-30 | 2018-03-06 | 农博士（福建）生物技术有限公司 | Milk cattle cultivating feed, feed addictive and preparation method thereof |
| CN107594205A (en) * | 2017-10-30 | 2018-01-19 | 农博士（福建）生物技术有限公司 | Broiler breeding feed, feed addictive and preparation method thereof |
| CN107594171A (en) * | 2017-10-30 | 2018-01-19 | 农博士（福建）生物技术有限公司 | Young pig's feed, feed addictive and preparation method thereof |
| CN107581377A (en) * | 2017-10-30 | 2018-01-16 | 农博士（福建）生物技术有限公司 | Feed for sow, feed addictive and preparation method thereof |
| CN109528681B (en) * | 2018-12-12 | 2021-05-25 | 华南农业大学 | A chlortetracycline microcapsule granule for ruminant oral administration and its preparation method |
| CN110419633B (en) * | 2019-07-25 | 2022-05-03 | 湖南江海环保实业有限公司 | Slow-release feed-grade ammonium chloride and preparation method thereof |
| CN111214455B (en) * | 2020-01-10 | 2021-09-28 | 北京东方天合过瘤胃技术研究院有限公司 | Rumen bypass vitamin D3And method for preparing the same |
| EP4108095A1 (en) | 2021-06-22 | 2022-12-28 | Fundación Tecnalia Research & Innovation | Microcapsules containing gamma-aminobutyric acid |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1752049A1 (en) * | 2004-05-24 | 2007-02-14 | Nippon Zenyaku Kogyo Co., Ltd. | Feedstuff and gamma-aminobutyric acid feeding method |
| CN101507510A (en) * | 2009-02-17 | 2009-08-19 | 安徽来福高科股份有限公司 | Preparation method of health-care food raw-material Y-aminobutyric acid |
-
2010
- 2010-01-12 CN CN2010100396301A patent/CN102125168B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1752049A1 (en) * | 2004-05-24 | 2007-02-14 | Nippon Zenyaku Kogyo Co., Ltd. | Feedstuff and gamma-aminobutyric acid feeding method |
| CN101507510A (en) * | 2009-02-17 | 2009-08-19 | 安徽来福高科股份有限公司 | Preparation method of health-care food raw-material Y-aminobutyric acid |
Non-Patent Citations (2)
| Title |
|---|
| 新型饲料添加剂―γ-氨基丁酸的制备及应用研究进展;赵炳超等;《中国畜牧兽医》;20041231;第31卷(第12期);13-14 * |
| 赵炳超等.新型饲料添加剂―γ-氨基丁酸的制备及应用研究进展.《中国畜牧兽医》.2004,第31卷(第12期),13-14. |
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| CN102125168A (en) | 2011-07-20 |
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