KR101891026B1 - Feed additive as substitutes of antibiotic for piglet, and processing method of it - Google Patents

Abstract

The present invention relates to a feed additive for an antibiotic substitute for preventing a diarrhea of a baby pig, and a producing method thereof. The feed additive of the present invention comprises a caproic acid (C6), a caprylic acid (C8), a capric acid (C10), an essential oil consisting of a specific component, a short chain polymer, a specific complex organic acid or a single organic acid (fumaric acid), and other diluting agents.

Description

[0001] The present invention relates to an improved antibiotic-replacement feed additive for preventing and alleviating diarrhea of a newborn pig,

The present invention relates to a feed additive that can be used in addition to a feed composition for newborn pigs. The feed additive has an effect of preventing and alleviating the diarrhea of newborn pigs and their growth stagnation by replacing antibiotics.

The most difficult problem in the breeding of newborn pigs is that they are fed in the weaning period starting from about 4 weeks after birth (28 days) to be.

Due to diarrhea caused by inadequate immune system incompleteness, changes in the intake environment during the period (changes in the digestive environment due to changes in feed type due to the conversion of liquid feed to solid feed) and subsequent growth congestion and diarrhea The mortality rate is high. These phenomena are an important problem for pig farming and pig farm management, as well as for growth and stagnation at high temperature in summer and for pig farming farmers.

Since the use of antibiotics has been banned, there have been some improvements in the environment and the development of new feed additives, which have resulted in some success. However, it is true that these effects are less effective than when antibiotics are used. The reality is that research and development must be carried out continuously.

Growth and growth rate of newborn pigs is relatively fast compared to other livestock or humans.

When weighing for the first 6 weeks after the birth of newborn pigs, calves, foals and infants, calves are only about twice the weight of birth weight, but the evidence is that infant pigs show a rapid growth of up to 10 times their body weight .

In contrast to this, during this period, changes in function related to digestion, such as changes in the size of newborn pigs, changes in small intestine, development of digestive enzymes, and changes in acidity in the stomach balance with growth and growth rate, such as rapid weight change of newborn pigs It is a problem that it can not achieve.

Therefore, in the case of newborn pigs, it is sensitive to small internal and external environmental changes including intestinal bacterial infection due to the imbalance between the growth rate, growth rate, and digestive-related functions such as weight change. Diarrhea often occurs, and frequent diarrhea often causes the growth and growth of newborn pigs to stagnate or lead to death, and the process of breeding newborn pigs has a great impact on the management profit of pig farmers to be.

In the present invention, a newborn pig refers to a pig between the age of 28 and 42 days of age.

In fact, if the growth of newborn pigs stagnates due to diarrhea after the reason in the breeding of newborn pigs, it will be affected until shipment of newborn pigs to the market, delaying shipment day by 15-25 days. In addition, feed consumption is also increased by 19-25 kg, which greatly affects the productivity and profitability of the pig farm. Therefore, prevention of diarrhea of the pig is the most important factor for the success of pig farming. It is a well-known fact for companies, and most of the technology for the development of feed additive related to pigs is highly related to the prevention of diarrhea of newborn pigs, especially infant pigs.

Therefore, it was a general phenomenon that a certain amount of antibiotics was mixed with a combination feed before the antibiotic use regulation was made when preparing a mixed feed for infant pigs.

However, since antibiotics injected for the prevention of diarrhea accumulate in the body of pigs and may be harmful to humans through the process of accumulation of metastasis into the body when they are ingested, in Korea, since July 2011, As with countries, the addition of antibiotics was prohibited by law in all formulated diets and when farmers wanted to use antibiotics directly, they could be bought and used separately under the veterinarian's diagnosis.

Therefore, it has become a major challenge to develop and use means to replace antibiotics in the pig farming industry as well as in the swine industry.

In particular, in the case of infant pig feed, the tendency to rely on antibiotics to prevent diarrhea was higher than in other animals, as well as in the breeding and finishing stages (breeding pigs and finishing pigs) It is the industry that has done it.

However, it is not yet possible to develop a feed additive that can completely replace antibiotics directly, both at home and abroad.

However, it is not possible to directly substitute antibiotics for continuous research. However, it is not possible to directly substitute antibiotics, but it is also possible to increase the immunity or to add substances such as organic acid, nucleotide, and β-D-Glucan, And the effect of the antibiotic is partially replaced by a method such as addition of the antibiotic.

However, it is difficult to limit the effect of the antibiotics. Therefore, it is known that some farmers use antibiotics without diagnosis of veterinary surgeons. Therefore, The development of appropriate means is a major challenge in the livestock industry, particularly in the breeding of newborn pigs, and many researchers are working on the development of feed additives that can replace the antibiotics in this area and bring about the same level of effectiveness. Especially, even though they are high prices, consumers' interest and consumption desire for non-antibiotic livestock products and organic livestock products are higher than before, and even though the production cost is increased due to expensive feed additive, It is true that the interest, demand and willingness of swine farmers and swine farmers to such feed additives are much greater than ever before.

The present invention relates to a feed additive for an antibiotic substitute for a newborn pig and a method for producing the same and a method for producing the same, which are disclosed in Japanese Patent No. 10-1256793 (Patent Application No. 10-1256793 -2011-0114213 / hereinafter referred to as "preliminary invention").

The "invention of the prefecture" has been trying to solve problems such as diarrhea, growth and growth congestion and mortality which are major obstacle factors in the growth after the weaning period of infant pigs. In trying to find the reason through repeated experiments and trial and error, I found that the main reason is that there is a high correlation between the specific fatty acids contained in animal milk and the ratios between them It was invented because it was caused by.

Based on the "advance invention", it is possible to prevent the diarrhea, which is the most important obstacle in real life, in the breeding of newborn pigs. Therefore, it is possible to replace the antibiotics applied to the newborn pig feeds to increase the feed intake, It is an object of the present invention to provide a feed additive for replacing antibiotics and a method for producing the same, which are superior to the "invention of the prior art" in that the time for conversion to breeding pigs can be made faster.

The present invention relates to a specific organic acid compound (Citric acid, Fumaric acid) of various organic acid complexes produced and sold as a substitute for antibiotics prior to the development of the product of the applicant of the present invention, acid, and lactic acid.) In the pig farms that used the combination of these three organic acids, the diarrhea ratio of infant pigs was significant In addition, the researchers found out that the poultry mortality rate of the newborn pigs is lower than that of the pigs, and that the researchers accidentally discovered the pig farming farmers in field technology consulting, .

On-site technical consulting for pig farmers is a system where our researchers visit farms and consult about the problems that arise when pig farming problems occur.

In addition, during the research and pilot production process, the organic acid contained in the complex organic acid and the fatty acids contained in the selection name are weakly bound to each other in the mixing process, so that the effect is maintained but the aggregation phenomenon does not occur (Fumaric acid) among the three organic acids constituting the specific complex organic acid agent of the present invention is combined with the feed additives of the first kind, the effect of the combined product of the complex organic acid agent is somewhat poor. However, It has been confirmed that it has a remarkably excellent effect as a substitute for antibiotics rather than the product of the selection name, but also the aggregation phenomenon is remarkably reduced. The addition of a product of the present invention in which a specific single organic acid agent (hereinafter referred to as a specific single organic acid agent refers to fumaric acid) to a compounded feed is superior to other feed additives in terms of mixing and flowability In addition, the present invention has been completed from another point of view. That is, the present invention enables users to selectively utilize the present invention as needed. It was confirmed that the combination of specific organic acid and fumaric acid was more effective than that of the selected product. However, when added to the compound feed as a feed additive, When the mixing and flowability are important, it is possible to solve the problem of mixing and flowability due to the slight aggregation occurring when the organic acid compound is combined with fumaric acid, The inventors of the present invention judged that the invention of a product in which an organic acid (Fumaric acid) is combined is also very significant in a manufacturing field. In products that require uniform mixing of the product, it is necessary to add an additional process (a process of squeezing and squeezing the product with a little pressure and re-introducing it again) to solve the problem of slight aggregation.

The feed additive for the replacement of antibiotics for the newborn pig of the present invention is a mixture of caproic acid (C6), caprylic acid (C8), capric acid (C10) and An essence oil composed of a specific component, a short-chain polymer, and other excipients plus a specific complex organic acid or a specific single organic acid.

However, the content ratio of the constituent components of the present invention is slightly different from the content ratio of the constituent components constituting the present invention. In the present invention, the constituent ratios of the short-chain polymer and the excipient are respectively reduced to about half, and the composition is replaced with a specific complex organic acid or a specific single organic acid.

The present invention relates to a cosmetic composition comprising 25-30% by weight of caproic acid, 15-20% by weight of caprylic acid, 10-15% by weight of capric acid, 10-12% by weight of short chain polymer, 5-9% by weight of other excipients, 15-20% by weight of a specific complex organic acid or specific single organic acid.

The characteristics of the raw materials other than the specific complex organic acid or the specific organic acid among the raw materials used in the present invention are the same as described in the "present invention". Caproic acid, caprylic acid and capric acid can be obtained from the mother's milk such as cattle, goat, rabbit and the like, but the object of the present invention is to be economically viable as an additive for feed And the ease of acquisition, it is preferable to obtain it from a vegetable oil. Further, in the present invention, it is preferable to use caproic acid, caprylic acid, capric acid, Capric acid is used.

The short chain polymer used in the present invention is rice hydrolyzed glucose obtained by hydrolyzing rice. It has a very good absorption ability even in a field of an infant pig which has not developed an absorption environment.

The essence oil made of the specific ingredients of the present invention is an oil obtained from a herb plant. The essence oil composed of the specific ingredients used in the present invention refers to a vegetable oil composed mainly of Thymol, Carvacrol, Capsaicin and Pinene as follows.

Specific complex organic acid agents are composed of citric acid, fumaric acid, and lactic acid as described above. The use of Fumaric Acid (fumaric acid) alone as a single organic acid agent rather than a specific organic acid agent was somewhat less effective. However, since a slight aggregation phenomenon occurred when a complex organic acid agent was used did not occur, It was also confirmed that the preparation process was simple, and there was no problem in the mixing ability when added in the formulated feed. In other words, it means that there is no problem in long-term storage without needing additional work at the top of the manufacturing process. The reason for using organic acid as a substitute for antibiotics for the prevention of diarrhea in newborn pigs is that the organic acid helps prevent diarrhea, but it is difficult to clearly identify which organic acid is more effective , It is often the case that product designers and farmers use complex organic acids because they judge that any of them will be effective.

In fact, if the effect is obvious, the use of a single organic acid, which has effects in specific conditions, taking into account the environment of the breeding environment and other relationships with other ingredients, has many advantages in terms of manufacturing process and final product characteristics It is certainly. However, since it is difficult to confirm it, it can be seen only by using a general-purpose complex organic acid. However, in the present invention, the inventors of the present invention could not confirm the rationale to support theoretically that only fumaric acid among the three organic acids constituting the complex organic acid agent has a binding effect with the product of the prior invention. When all of the three organic acids constituting the complex organic acid agent were combined with each of the first choice products as a feed additive, the effect was lower than that of the specific complex organic acid agent combined. However, the combination of Fumaric acid with the product of the first choice was the closest to the effect of binding of the specific complex organic acid, and the most effective antibiotic substitute among the three organic acids was the most excellent. However, the product as a substitute for other antimicrobials of different organic acids was superior to the antimicrobial agent of the selected product, but it was not only comparable to the one bound to fumaric acid, but also had lower mixing and flow properties than products combined with fumaric acid Respectively. In other words, the improvement in properties such as the mixing and flow properties of the products each having a combination of lactic acid and citric acid did not improve the effect as an improved antibiotic substitute obtained by binding a specific complex organic acid .

Thus, the present inventors completed the present invention in consideration of the combination of the above-mentioned complex organic acid agent and the product of the "prior invention" and the product of the fumaric acid and the "invention invention" as a substitute for antibiotics and the advantages of the product manufacturer.

The excipient may be a variety of excipients such as white carbon, calcium carbonate, and finely pulverized rice husk. In general, any kind of excipient does not affect the essential purpose of the present invention as long as it can be used as an excipient in the preparation of a feed additive. The choice of excipient is not limited.

The feed additive for the antibiotic substitute of the present invention may be selected from the group consisting of caproic acid, caprylic acid, capric acid and an essence oil composed of a specific component, a short chain polymer and a specific complex organic acid or a single organic acid And can exhibit the effect as a substitute for antibiotics in accordance with the object of the present invention.

Further, the present invention relates to a cosmetic composition comprising at least one member selected from the group consisting of caproic acid, caprylic acid, essence oil consisting of capric acid and a specific component, short chain polymer and organic acid (specific complex organic acid and single organic acid) When mixed in a specific ratio range, the effect as an antibiotic substitute can be maximized.

The mixing ratio of the components that can maximize the effect is 25-30% by weight of caproic acid (C6), 15-20% by weight of caprylic acid (C8), 10% by weight of capric acid -15% by weight of an essential oil, 5-7% by weight of an essence oil comprising a specific component, 10-12% by weight of a short chain polymer, 15-20% by weight of a specific complex or single organic acid and 5-9% by weight of other excipients. The fact that the total sum of caproic acid, caryl acid and capric acid should be at least 50% by weight and that the caproic acid is greater than caprylic acid and caprylic acid is equal to or greater than caprylic acid, ".

Caproic acid, caprylic acid, and capric acid used in the present invention are in the form of a spray-dried powder. There are oil form and powder form in order to completely guarantee the dispersion of these components when mixed with other constituents, that is, the uniform dispersion of constituents.

When caproic acid, caprylic acid and capric acid are used in the form of powder, it is convenient to use an essence oil in powder form.

When caproic acid, caprylic acid, and capric acid are used in the form of oil, they are prepared by mixing these acids in advance with an essence oil and then spray-drying the mixture to a mixture of the short-chain polymer and other excipients. Products can be obtained.

Even if the essence oil alone is used in the form of an oil, it can be produced by spray drying an oil-type essence oil to a mixture of a fatty acid such as caproic acid in a powder form, a short-chain polymer and an excipient as described above.

Generally, since the organic acid is manufactured to have a size of 20 mesh or less, there is no problem in mixing with other powdery raw materials, and a difference in the effect can not be found by the order of mixing at the time of manufacturing, There is no problem even if they are mixed in any order using an organic acid agent in the form of a powder that is generally circulated.

However, in the present invention, in order to prevent the convenience of the manufacturing process and the properties of the final product, that is, the aggregation phenomenon, it is mixed with an excipient in advance and mixed with other raw materials.

In particular, when a complex organic acid is used, it is technically advantageous to use a mixture of an excipient when preparing the complex organic acid.

In the case of using a specific organic acid agent, since the organic acid agents are mixed with each other, slight aggregation may occur between the organic acid agents and the agglomeration phenomenon tends to increase with time. When the excipient to be used in the feed additive of the present invention is mixed and prepared in advance in the preparation of the complex organic acid agent, the effect of alleviating such aggregation can be obtained and the storage period can be extended. Even when a single organic acid agent is used, mixing the excipient and the single organic acid agent first and then mixing them with other constituent materials is effective in preventing aggregation with other ingredients except for the organic acid agent and the excipient. Therefore, it is another technical feature of the method of manufacturing the feed additive of the present invention that the specific single organic acid or specific organic acid used in the present invention is first mixed with an excipient and then mixed with other ingredients . Particularly, the inventors of the present invention have repeatedly experimented with the mixing process. As a result, in the process of binding with fatty acids used in the present invention, aggregation of organic acids and fatty acids is clearly confirmed. Therefore, It has been confirmed that a manufacturing process in which a single organic acid acid raw material is prepared by mixing with an excipient in advance and then mixed with other constituent raw materials including fatty acids is more effective. In addition, even if mixing the excipients and the organic acid agents in advance and then mixing the other ingredients, the aggregation phenomenon between the organic acid agents can be alleviated to some extent. However, since this is not completely solved, Considering the completeness, mixing with other raw materials, flow of product, etc., it is advantageous to use a product that combines only Fumaric acid with the product of choice. Therefore, It is as described above. This is because, regardless of which one of the two is selected, the effect as an antibiotic substitute material is superior to that of the selected product.

It should be noted, however, that the above description relates to a better manufacturing process, but the essence of the present invention lies in the combination of a specific complex organic acid or a single organic acid in the product of the selection. The effects of the present invention are not exhibited only under the specific manufacturing process described above and the mixing order of the raw materials is not different from the above description and there is no difference in the effect, It is necessary to add additional processes such as the use of additional grinding or wire drawing, so that the specific manufacturing process described above (mixing the excipient with the organic acids in advance Is added is a further invention combining the technical structure of the manufacturing process to obtain a further effect by further advancing the technique of bonding a specific compound or a single organic acid to the composition of the selection name, It is noted that the combination of the above techniques can not limit the scope of the present invention.

The constituents used in the present invention are those that can be easily manufactured or purchased by those of ordinary skill in the art. They are mainly used individually in food or feed fields in the market.

However, the inventors of the present invention have found the effect of the present invention as a substitute for antibiotics for newborn poultry, which is difficult to be predicted by a person skilled in the art from a mixture of these constituents, .

As a single agent, there is no known agent that can replace the existing antibiotic. Even if a mixture of various substances is mixed, it is difficult to directly confirm the effect as an antibiotic substitute. "The effect of which is significant enough to confirm the significance.

In preparing the antibiotic substitute of the present invention, when a long time mixing is carried out by adding caproic acid, caprylic acid, or capric acid into an essence oil, short-chain polymer, other excipient and a mixer for preparing feed, The fact that caproic acid, caprylic acid, and capric acid can cause problems in the properties and function of the product due to excessive friction heat and reaction between the acids is not disclosed in the prior invention Explanation is omitted because it has been explained.

Therefore, an essence oil, a short chain polymer, a single organic acid or a specific organic acid and other excipients which are not significantly influenced by frictional heat are mixed in a mixer for animal feed preparation to be mixed thoroughly, and then caproic acid, caprylic acid Caprylic acid and Capric acid are mixed in one of three kinds of fatty acids, mixed at a low speed for a short time, mixed with another fatty acid and mixed at a low speed. Thereby completing the feed additive of the present invention. The specific single organic acid or specific organic acid used in the present invention is mixed with an excipient to be used in advance and then mixed with other ingredients other than fatty acids (such as caproic acid) in a mixer for preparing feeds and then mixed with fatty acids As described above, in order to prevent the phenomenon of flowability and poor mixing when added to a compound feed due to aggregation of organic acids or aggregation of organic acids and fatty acids, And the quality improvement effect related to the preservation period is added to obtain the additional effect.

The feed additive of the present invention can be fed to infant pigs through a combination feed (paste-type pig feed, infant pig meal) by mixing at a ratio of 1-5% by weight in the production of infant feed for infant pigs . Of course, it is also possible to feed directly from the livestock farmer in a top dressing method within a range of 1-5 wt% on the compound feed.

The feed additive for the replacement of antibiotics for infant pigs of the present invention reduces diarrhea caused by diarrhea of newborn pigs, prevents growth and delay of growth, improves intestinal environment in spite of increased feed intake, And it is possible to increase not only the amount of the newborn pig but also the amount of the newborn pig.

In addition, antibiotics can supply untransferred pork, which not only has a positive impact on public health, but also gives economic benefits to livestock farmers.

In preparing the feed additive for the antibiotic substitute of the present invention, an organic acid agent and other excipients are mixed in advance, then mixed with the components other than the fatty acid, and the fatty acids are mixed one by one in the final step It was confirmed that by improving the dispersion degree, the flowability, the mixing property, etc. of the product, it is possible to influence the property of the product and thus the effect as an antibiotic substitute.

Hereinafter, the structure and operation of the present invention will be described in more detail with reference to the preferred embodiments of the present invention. It should be understood, however, that the present invention is not limited to the disclosed embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims. Those skilled in the art will appreciate that the contents not described herein are sufficiently technically inferior to those of ordinary skill in the art.

26 kg of other excipients and a specific complex organic acid (for convenience of production, citric acid, fumaric acid and lactic acid are mixed at a ratio of 1: 1: 1 in a conventional mixer for producing feeds (ribbon type) If the addition ratio of one of the organic acid agents is not lowered to 10 wt% or less, no difference in specific effect can be found, and it is normally convenient to make the ratio of each organic acid equal. , 80 kg of caproic acid was added to the mixture in the mixer manufactured by the two-step process in which 15 kg of essence oil (powder form) and 34 kg of short-chain polymer were put and mixed at 60 rpm for 5 minutes 52 kg of caprylic acid was added to the mixture in a mixer consisting of a three-step process of mixing for 1 minute and 30 seconds at a speed of 45 rpm and a third process, followed by mixing at 45 rpm for 1 minute and 30 seconds (37 kg) of capric acid was added to the mixture in a mixer consisting of a 4-step process and a 4-step process, and the mixture was mixed at 45 rpm for 1 minute and 30 seconds. Thus, 300 kg of an antibiotic substitute for poultry An additive was obtained.

In Example 1, except that 56 kg of Fumaric acid was used as a single organic acid instead of the specific organic acid, the feed ratio of each constituent material was the same as that of Example 1, and 300 kg of feed for the replacement of antibiotics An additive was obtained.

(56 kg), essence oil (powder form) 15 kg, short-chain polymer 34 kg, other excipients 26 kg, caproic acid 80 kg, caprylic acid, and the like were mixed in a mixer (ribbon type) 52 kg, and 37 kg of capric acid, and the mixture was operated at a speed of 60 revolutions / minute for 5 minutes to obtain 300 kg of feed additive for antibiotic substitute for newborn pigs.

Except that 56 kg of Fumaric acid was used as a single organic acid instead of the specific organic acid in Example 3, the feed ratio of each constituent material was the same as that of Example 3, and 300 kg of feed for antibiotic substitute for newborn pig An additive was obtained.

Comparative Example 1 (Prior invention)

15 kg of essence oil (powder form), 67 kg of short chain polymer, and 49 kg of other excipient are placed in a conventional mixer for producing feed (ribbon type) and mixed at a rate of 60 revolutions / minute for 5 minutes. 52 kg of caprylic acid was added to the mixture in a mixer consisting of a two-step process and a two-step process in which 80 kg of caproic acid was added to the mixture in a blender and mixed at 45 rpm for 1 minute and 30 seconds, (37 kg) of capric acid was added to the mixture in a mixer consisting of a 3-step process and a 3-step process in which the mixture was mixed at a revolution / minute rate for 1 minute and 30 seconds. 300 kg of feed additive for antibiotic replacement for newborn pigs was obtained.

Comparative Example 2

It is a mixed feed for infant pigs that does not contain antibiotics that are usually sold on the market.

The effects of the feed additives of the present invention (Examples 1, 2, 3 and 4) on the growth and growth of diarrhea, growth congestion, mortality and the like of newborn pigs were examined by the farm test according to the test methods described below, The results were as shown in Table 1 below.

□ Test method

One hundred sixty two newborn pigs were divided into six groups of 60 pigs. In one group, the feed additive obtained in Comparative Example 1 was added to the mixed feed for infant pigs (weaning group), which is usually available at a commercial food store or a distributor, %, And one group was fed with a commercially available compound feed for infant pigs (for weaning) (Comparative Example 2).

In the remaining four groups, the feed additives of the present invention obtained in Examples 1, 2, 3 and 4 were mixed in an amount of 3% by weight in each of the conventional mixed feed for pigs (for weaning purposes) and fed.

The above-described conventional infant feed compositions for pigs were used for the purpose of confirming the effect of the same company product (a mixed feed for a newborn pig of Woosung Feed Co., Ltd.).

The reason for the infant pigs is that when the premature reason is performed, the infant is given the reason for the infant beginning from the twenty-first day of life. However, in most cases, The test was carried out with the age of 28 as the cause. As already mentioned above, in the present invention, a newborn pig refers to a pig between the age of 28 and 42 days of age, and the following specification test was also performed during this period.

The results shown in Table 1 below are obtained by averaging the results of the experiment three times repeatedly under the above conditions in consideration of changes in the breeding environment.

The number of piglets disclosed in Examples 1, 2, 3, and 4 and Comparative Examples 1 and 2 was 1,080 (three replicates were repeated 360 times each under identical feeding conditions, For comparison, the number of piglets administered was 60. Therefore, 360 pigs were administered per breeding test. Actually, pigs were able to breed 30 dogs, I used the money room)

* Comparative Example 2 was prepared by feeding one of the feeds for infant pigs not containing antibiotics which are usually sold in the market as described above (in this case, the manufacturer can substitute antibiotics And the other additives were mixed with other feed additives. As a result, it was confirmed that the compound was used as a raw feed for pigs. The feed additives for Examples 1 to 4 and Comparative Example 1 were added to each of the infant feed compositions for infant pigs.

※ The mean weight at the time of weaning is the total weight of weaning weight of the 28th instar pigs divided by the total number of pigs (60 × 3 = 180) per test group. Except for pigs that were over or over 0.5 kg in average body weight, they were replaced with another infant pig.

※ The final average body weight is the total weight of the weights of the 42-year-old infant pigs whose experimental wages were terminated divided by the total number of piglets (60 × 3 = 180) per test group. Except for the old-born pigs In this case, the total number of pigs was excluded.

※ The number of piglets in diarrhea is the total number of piglets with diarrhea among 160 piglets donated to each group.

※ The dead pigs were excluded from the calculation of the final average weight and average daily feed intake, and included in the calculation of the number of diarrhea pigs

※ The ratio of dead pigs is the number of piglets treated with the disease caused by persistent diarrhea and other immunity depression within the test period (14 days)

The results of Table 1 show that the ratio of dead pigs and diarrhea pigs, which are factors that have an absolute impact on the management of the pig farm, are significantly different between the feeds according to Examples 1 and 2 and the feed according to Comparative Example 1 It can be seen that there is a difference in the effect of confirming the significance. The difference in the remarkable effect can be confirmed between the comparative example 2 and the first and second embodiments. Further, there was no difference in the raw materials used in the mixing, but there was a significant difference in the ratio of dead piglets and diarrhea piglets in the comparison between Example 1 and Example 3, and Example 2 and Example 4, appear. As described above, the difference between Example 1 and Example 3 and Example 2 and Example 4 is that the organic acid and fatty acid (such as caproic acid) added as effective ingredients in the present invention are contained in the final infant feed composition It is confirmed that the two phenomena are due to the fact that the phenomenon of uniform distribution without agglomeration and the safety of the material due to the reduction of time for exposure to heat due to the sequential injection of fatty acids into the mixing process.

The final average body weight was also higher in Example 1 and Example 2 than in Comparative Example 1 and significantly higher than Comparative Example 2 because the feed additive of the present invention had a beneficial effect on the environment of the infant pig As a result, it can be said that the amount of gain per day (meaning a low rate of feed demand) is relatively high due to the composition of a good intestinal environment. In addition, it can be seen from the table that the overall difference shows significant differences in effect from Examples 3 and 4 and Comparative Example 1 and Comparative Example 2.

In conclusion, as shown in the above test results, it was confirmed that the effect of the antibiotic substitute was better than that of Comparative Examples 1 and 2 in all the groups of Examples 1, 2, 3 and 4, In particular, it can be confirmed that the effect is more excellent in Examples 1 and 3, in which a specific complex organic acid is added, so that the binding of a specific organic acid, more preferably a specific complex organic acid, The fact that a synergistic effect occurs in addition to the above is proven by the specification test. It can also be seen that Examples 1 and 2 prepared according to the process presented in the present invention have better effects than Examples 3 and 4 when Examples 1 and 3 and Example 2 and Example 4 are compared with each other have. That is, it is possible to confirm the effect by combining a specific organic acid agent (including a specific complex organic acid system) in the present invention, but it is possible to maximize the effect of binding a specific complex organic acid agent, It has been confirmed through the specification test that it is possible to increase the effect by manufacturing through the specified process procedure.

Claims (4)

25-30% by weight of caproic acid (C6), 15-20% by weight of caprylic acid (C8), 10-15% by weight of capric acid (C10), thymol, 5-7% by weight of vegetable essence oil consisting of carvacrol, capsaicin and pinene, 10-12% by weight of rice hydrolyzed glucose, citric acid, fumaric acid, lactic acid, acid, and 5-9% by weight of an excipient. 25-30% by weight of caproic acid (C6), 15-20% by weight of caprylic acid (C8), 10-15% by weight of capric acid (C10), thymol, 5-7% by weight of vegetable essence oil consisting of carvacrol, capsaicin and pinene, 10-12% by weight of rice hydrolyzed glucose, 15-20% by weight of fumaric acid and 5- 9% by weight of feed additive for antibiotic substitute for newborn pigs. A step of mixing and mixing 15 to 20% by weight of a complex organic acid comprising 5-9% by weight of an excipient and citric acid, fumaric acid and lactic acid in a feed mixer, 5-7% by weight of vegetable essence oil consisting of thymol, carvacrol, capsaicin, and pinene and 10-12% by weight of rice hydrolyzed glucose were added to the mixture in the mixer manufactured by A mixture of 25-30% by weight of caproic acid, 15-20% by weight of caprylic acid, 10-20% by weight of capric acid, 15% by weight, and mixing the mixture at a speed of 45 rpm for 1 minute and 30 seconds, and a step of 3. One of the remaining two kinds of the acid was added to the mixture in the blender, and the mixture was stirred at 45 rpm for 1 minute A mixer having a four-step process of mixing for 30 seconds and a four-step process A step of adding the last remaining acid to the mixture and mixing at a rate of 45 revolutions / minute for 1 minute and 30 seconds, to prepare a feed additive for an antibiotic substitute for a newborn pig. The mixture in the mixer prepared by the first step and the first step of mixing 5 to 9 wt% of excipient and 15 to 20 wt% of fumaric acid in a mixer for preparation of feed is mixed with thymol, 5-7% by weight of vegetable essence oil consisting of carvacrol, capsaicin and pinene and 10-12% by weight of rice hydrolyzed glucose are mixed and mixed in a mixer in a two-stage process 25-30% by weight of caproic acid, 15-20% by weight of caprylic acid and 10-15% by weight of capric acid, and the mixture was stirred at 45 rpm for 1 minute A mixture in a mixer consisting of a 4-step process in which one of the remaining two kinds of acids is added to a mixture in a blender consisting of a 3-step process for mixing the mixture for 30 seconds and a 1-minute and 30-second process at 45 rpm, , And at 45 revolutions per minute for 1 minute and 30 seconds A method for preparing a feed additive for an antibiotic substitute for a newborn pig, comprising a five step process of mixing the same.