CN106580887A - Marbofloxacin soluble pulvis - Google Patents
Marbofloxacin soluble pulvis Download PDFInfo
- Publication number
- CN106580887A CN106580887A CN201710000291.8A CN201710000291A CN106580887A CN 106580887 A CN106580887 A CN 106580887A CN 201710000291 A CN201710000291 A CN 201710000291A CN 106580887 A CN106580887 A CN 106580887A
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- Prior art keywords
- marbofloxacin
- soluble
- soluble powder
- pulvis
- powder according
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a marbofloxacin soluble pulvis. The marbofloxacin soluble pulvis comprises, by weight, 4.0-25% of marbofloxacin, 1.0-45% of sodium carbonate, 0.1-1.0% of a perfume, and the balance of a soluble filler. The marbofloxacin soluble pulvis prepared through a method disclosed in the invention has the characteristics of simplicity in use, low cost, complete fragrance, stability in storage, convenience in transportation, and good water solubility. An aqua prepared in the invention greatly improves the curative effects of themarbofloxacin soluble pulvis, is a novel wide-spectrum and high-efficiency special pulvis for animals, and enriches the variety of antibiotics in the veterinary medicine market.
Description
Technical field
The present invention relates to biomedicine technical field, more particularly to a kind of veterinary antibiotic pharmaceutical preparation, more particularly to one
Plant Marbofloxacin soluble powder and preparation method thereof.
Background technology
Marbofloxacin (Marbofloxacin), is animal specific third generation Comprecin also known as marbofloxacin
Thing.Marbofloxacin is the growth by suppressing the DNA transcriptases of antibacterial so as to suppress antibacterial, to gram negative bacteria, gram
Positive bacteria and mycoplasma have antibacterial action, can be absorbed well by oral and drug administration by injection, and toxic and side effects are relatively low.And should
Medicine as seldom there is untoward reaction during veterinary medicine, and to resistance to following medicine such as erythromycin, lincomycin, chloromycetin, strong
Power mycin, sulphonamidess pathogen it is still effective.
Marbofloxacin works well for treating dog, the various skins of cat, digestive tract, respiratory tract infection and postoperative infection.
It is 2-4mg/kg that clinic recommends dosage, by daily single, oral, subcutaneous injection or intravenous drip can be carried out as needed.
Clinically based on the Marbofloxacin injection of various concentration.But Marbofloxacin solution, thermal sensitivity is high, easy decomposed metamorphic, and
Transport inconvenience.Unresolved the problems referred to above, the present invention comes therefrom.
The content of the invention
Present invention aim at provide one kind can either Quick medicine and acting duration is long, side effect can be reduced again
Marbofloxacin soluble powder.
For solve above-mentioned technical problem, the Marbofloxacin soluble powder of the technical scheme of first aspect present invention, its by
The raw material composition of following percentage by weight：
Preferably, Marbofloxacin soluble powder, it is comprised the following raw materials by weight percent：
Preferably, Marbofloxacin soluble powder, it is comprised the following raw materials by weight percent：
Preferably, the one kind of the spice in musk odorant or cinnamon flavor.
Preferably, the soluble filler is edible or medical filler, or in solubility correctivess one or two with
On, the one kind of filler in soluble starch or glucose is eaten, the solubility correctivess are selected from sucrose, Lactose or saccharin
One or more in sodium.
The preparation method of Marbofloxacin soluble powder, comprises the steps：
1) Marbofloxacin in formula, sodium carbonate, spice, soluble filler are respectively dried so as to which water content is less than
5%,
2) above-mentioned each component crushed again, is crossed 60 to 80 mesh sieves, it is standby：
3) by charge ratio, above-mentioned each component is thoroughly mixed 25-45 minutes, you can obtain Marbofloxacin soluble powder
Agent.
The raw material of the present invention, the Marbofloxacin of adjuvant, sodium carbonate, spice, soluble filler are commercially available prod.
Percentage ratio in the present invention is weight percentage.
Relative to scheme of the prior art, it is an advantage of the invention that：The Marbofloxacin that the method for the present invention is prepared can
Soluble powder has the features such as using various simple, with low cost, fragrance, stable storing, convenient transportation, good water solubility；Prepare
Into water preparation be greatly improved the curative effect of Marbofloxacin soluble powder, be a kind of new, wide spectrum, efficient animal specific powder
Agent, enriches Antibiotics in veterinary drug market.
Specific embodiment
Such scheme is described further below in conjunction with specific embodiment.It should be understood that these embodiments are for illustrating
The present invention and be not limited to limit the scope of the present invention.The implementation condition adopted in embodiment can be done according to the condition of concrete producer
Further adjustment, not marked implementation condition is usually the condition in normal experiment.
Embodiment 1
Marbofloxacin soluble powder, its mainly with Marbofloxacin, sodium carbonate as major ingredient (containing 10% Marbofloxacin, 45%
Sodium carbonate), appropriate spice, solubility correctivess and soluble filler are equipped with, via drying, weigh, crush, stirring, mixing
The conventional methods such as even, inspection, metering, packaging are prepared from.
Its formula is：
Concrete production method：
(1) above-mentioned raw materials are dried so as to which water content is less than 5%.
(2) weigh, the raw material of said components is fully crushed, and process of sieving is carried out with 60 to 80 mesh sieves；
(3) above-mentioned raw materials after sieving are poured in V-Mixer, is sufficiently stirred for 25 minutes, mix homogeneously；
(4) sample examination, check the percentage ratio of material content, powder fineness it is whether up to standard, whether water content qualified etc.；
(5) metering weigh, be packaged into bag, per it is packed enter 5 grams, 10 grams or 100 grams above-mentioned powder, obtain final product Marbofloxacin solvable
Property powder.
Embodiment 2
The described Marbofloxacin soluble powder of the present embodiment, containing 10% Marbofloxacin, 45% sodium carbonate, 1% Moschus
Spice, 30% solubility correctivess, 14% starch.By 10 grams of Marbofloxacins, 45 grams of sodium carbonate, 1 gram of musk odorant, 30 grams of sugarcanes
Sugar, the drying of 14g starch so as to which water content is less than 5%, weighs, and the raw material of said components is fully crushed, and with 60 to 80 mesh sieves
Carry out process of sieving.Above-mentioned former, adjuvant after sieving is poured in V-Mixer, is sufficiently stirred for 25 minutes, mix homogeneously.
Sample examination, check the percentage ratio of material content, powder fineness it is whether up to standard, whether water content qualified etc., meter
Amount is weighed, and is packaged into bag, per it is packed enter 5 grams, 10 grams or 100 grams above-mentioned powder, obtain final product Marbofloxacin soluble powder.
Embodiment 3
The described Marbofloxacin soluble powder of the present embodiment, containing 20% Marbofloxacin, 10% sodium carbonate, 1% Moschus
Spice, 25% Lactose, 44% glucose.By 20 grams of Marbofloxacins, 15 grams of sodium carbonate, 1 gram of musk odorant, 25 grams of Lactose, 44g Portugals
Grape sugar drying so as to which water content is less than 5%, weighs, and the raw material of said components is fully crushed, and is carried out with 60 to 80 mesh sieves
Sieve process.Above-mentioned former, adjuvant after sieving is poured in V-Mixer, is sufficiently stirred for 25 minutes, mix homogeneously.
Sample examination, check the percentage ratio of material content, powder fineness it is whether up to standard, whether water content qualified etc., meter
Amount is weighed, and is packaged into bag, per it is packed enter 5 grams, 10 grams or 100 grams above-mentioned powder, obtain final product Marbofloxacin soluble powder.
Examples detailed above technology design only to illustrate the invention and feature, its object is to allow the person skilled in the art be
Will appreciate that present disclosure and implement according to this, can not be limited the scope of the invention with this.It is all smart according to the present invention
Equivalent transformation or modification that refreshing essence is done, all should be included within the scope of the present invention.
Claims (7)
1. Marbofloxacin soluble powder, it is comprised the following raw materials by weight percent：
2. Marbofloxacin soluble powder according to claim 1, it is characterised in that its by following percentage by weight original
Material composition：
3. Marbofloxacin soluble powder according to claim 1, it is characterised in that its by following percentage by weight original
Material composition：
4. the Marbofloxacin soluble powder according to any one of claim 1-3, it is characterised in that the spice is selected from Moschus moschiferouss
One kind in spice or cinnamon flavor.
5. the Marbofloxacin soluble powder according to any one of claim 1-3, it is characterised in that the soluble filler
For edible or medical filler, or one or more in solubility correctivess.
6. Marbofloxacin soluble powder according to claim 5, it is characterised in that the edible filler is selected from solubility
One kind in starch or glucose.
7. Marbofloxacin soluble powder according to claim 5, it is characterised in that the solubility correctivess are selected from sugarcane
One or more in sugar, Lactose or saccharin sodium.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710000291.8A CN106580887A (en) | 2017-01-02 | 2017-01-02 | Marbofloxacin soluble pulvis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710000291.8A CN106580887A (en) | 2017-01-02 | 2017-01-02 | Marbofloxacin soluble pulvis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106580887A true CN106580887A (en) | 2017-04-26 |
Family
ID=58582091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710000291.8A Pending CN106580887A (en) | 2017-01-02 | 2017-01-02 | Marbofloxacin soluble pulvis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106580887A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107441111A (en) * | 2017-07-04 | 2017-12-08 | 江西傲新生物科技有限公司 | A kind of composition for treating respiratory tract infection of pigs and preparation method thereof |
| CN107648192A (en) * | 2017-10-25 | 2018-02-02 | 佛山科学技术学院 | A kind of Marbofloxacin flavor piece and preparation method thereof |
| CN110141558A (en) * | 2019-05-29 | 2019-08-20 | 四川农业大学 | A kind of preparation method of marbofloxacin nanoparticle |
| CN113545483A (en) * | 2021-07-21 | 2021-10-26 | 陕西科技大学 | Spleen and stomach benefiting elderly person coagulating powder and preparation method thereof |
| CN114886893A (en) * | 2021-07-30 | 2022-08-12 | 江苏恒丰强生物技术有限公司 | Compound amoxicillin powder and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011104652A2 (en) * | 2010-02-24 | 2011-09-01 | Pfizer Inc. | Veterinary compositions |
| CN102397552A (en) * | 2010-09-10 | 2012-04-04 | 广州自远生物科技有限公司 | Medicinal composite preparation containing quinolones, preparation method thereof and application thereof |
| CN102406613A (en) * | 2011-09-30 | 2012-04-11 | 上海恒丰强动物药业有限公司 | Super tylosin soluble powder and preparation method thereof |
| CN103271875A (en) * | 2013-07-01 | 2013-09-04 | 浙江华尔成生物药业股份有限公司 | Marbofloxacin freeze-dried powder for injection and preparation method and application thereof |
-
2017
- 2017-01-02 CN CN201710000291.8A patent/CN106580887A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011104652A2 (en) * | 2010-02-24 | 2011-09-01 | Pfizer Inc. | Veterinary compositions |
| CN102397552A (en) * | 2010-09-10 | 2012-04-04 | 广州自远生物科技有限公司 | Medicinal composite preparation containing quinolones, preparation method thereof and application thereof |
| CN102406613A (en) * | 2011-09-30 | 2012-04-11 | 上海恒丰强动物药业有限公司 | Super tylosin soluble powder and preparation method thereof |
| CN103271875A (en) * | 2013-07-01 | 2013-09-04 | 浙江华尔成生物药业股份有限公司 | Marbofloxacin freeze-dried powder for injection and preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 袁宗辉等: "《饲料药物学》", 30 November 2001, 中国农业出版社 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107441111A (en) * | 2017-07-04 | 2017-12-08 | 江西傲新生物科技有限公司 | A kind of composition for treating respiratory tract infection of pigs and preparation method thereof |
| CN107648192A (en) * | 2017-10-25 | 2018-02-02 | 佛山科学技术学院 | A kind of Marbofloxacin flavor piece and preparation method thereof |
| CN110141558A (en) * | 2019-05-29 | 2019-08-20 | 四川农业大学 | A kind of preparation method of marbofloxacin nanoparticle |
| CN113545483A (en) * | 2021-07-21 | 2021-10-26 | 陕西科技大学 | Spleen and stomach benefiting elderly person coagulating powder and preparation method thereof |
| CN114886893A (en) * | 2021-07-30 | 2022-08-12 | 江苏恒丰强生物技术有限公司 | Compound amoxicillin powder and preparation method thereof |
| CN114886893B (en) * | 2021-07-30 | 2023-09-29 | 江苏恒丰强生物技术有限公司 | Compound amoxicillin powder and preparation method thereof |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170426 |
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| RJ01 | Rejection of invention patent application after publication |