CN101979092A - Water-soluble veterinary pharmaceutic adjuvant optimal sugar and preparation process thereof - Google Patents
Water-soluble veterinary pharmaceutic adjuvant optimal sugar and preparation process thereof Download PDFInfo
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- CN101979092A CN101979092A CN2010105328419A CN201010532841A CN101979092A CN 101979092 A CN101979092 A CN 101979092A CN 2010105328419 A CN2010105328419 A CN 2010105328419A CN 201010532841 A CN201010532841 A CN 201010532841A CN 101979092 A CN101979092 A CN 101979092A
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Abstract
The invention provides water-soluble veterinary pharmaceutic adjuvant optimal sugar and a preparation process thereof, which belong to the field of the production of raw materials of veterinary medicaments. The preparation process comprises the following steps of: dissolving magnesium sulfate dodecahydrate, sodium sulphate dihydrate, dextran, dextrine and an appropriate amount of citric acid at high temperature and then cooling to agglomerate; and performing the steps of hydrolyzing and stirring, drying at the temperature of 200 DEG C and the like to obtain crystalline powder. The product has stable properties and pH value and low activity, is difficult to react with medicaments, is nonhygroscopic, is not agglomerate, does not discolor, has high dispersibility and fluidity, and is soluble in water; and the aqueous solution has high clarity; and the water-soluble veterinary pharmaceutic adjuvant optimal sugar has high adsorbability and affinity, has sustained-release and synergy effect and is a stable and efficient veterinary pharmaceutic adjuvant.
Description
Technical field:
The present invention relates to a kind of excellent sugar of new type water-solubility veterinary drug pharmaceutic adjuvant and preparation technology thereof, belong to veterinary drug raw material production field.
Background technology:
Fast development along with China's aquaculture, the application of veterinary drug and feed additive is increasingly extensive, now become a ring important in the modern farming, in the veterinary drug of becoming increasingly prosperous is produced, the veterinary drug adjuvant is widely used, but the veterinary drug carrier of present domestic use is mainly glucose, its shortcoming is the easy moisture absorption, easily lump, mobile poor, be difficult for mix homogeneously with medicine, and sweet taste is heavy, and many animals are not liked feed and drink, and makes to enter the intravital medicine of animal and do not reach and require dosage, influence therapeutic effect, so use product one listing of glucose, caking or metachromatism just occur in the very short time, simultaneously some medicine and the easy chemically reactive of glucose as adjuvant, cause and to add, for example neomycin, ammonium chloride etc.
So a kind of stable in properties of urgent need, pH value were stablized during modern veterinary drug was produced; Active low, be difficult for and medicine reacts, nonhygroscopic, do not lump, invariant color; While product dispersibility, good fluidity, soluble in water, aqueous solution clarity height has stronger adsorptivity and affinity, has the pharmaceutic adjuvant of sustained-release synergistic effect.
Excellent sugar is the complex of being made through high-temperature process by plurality of inorganic salt, glucosan, dextrin and citric acid etc.It has stable in properties, good water solubility, mobile good, color and luster evenly, be difficult for moisture absorption and characteristics such as do not lump.With this product is the powder pre-mixing agent of substrate, nonhygroscopic, do not lump, invariant color, help medicine and absorb in animal body and distribute, to improving bioavailability of medicament and increasing curative effect bigger help is arranged.
Summary of the invention:
Technical problem
The invention provides a kind of veterinary drug water solublity pharmaceutic adjuvant, it has stable in properties, PH is stabilized between the 6.5-7, good water solubility, mobile good, color and luster evenly, be difficult for moisture absorption and characteristics such as do not lump.
Technical scheme
A kind of veterinary drug water solublity pharmaceutic adjuvant is characterized in that: described veterinary drug water soluble adjuvant is made up of following raw material:
● excellent sugar (white)
1) 12 water magnesium sulfates: 40%
2) 2 aqueous sodium persulfates: 35%
3) glucosan: 15%
4) dextrin: 10%
● excellent sugar (yellow)
1) 12 water magnesium sulfates: 40%
2) 2 aqueous sodium persulfates: 35%
3) glucosan: 15%
4) dextrin: 6%
5) citric acid: 4%
Simultaneously, the veterinary drug water soluble adjuvant among the present invention is characterized in that: described veterinary drug water soluble adjuvant adopts following prepared:
● excellent sugar (white)
1) earlier with 12 water magnesium sulfates, 2 aqueous sodium persulfates, glucosan, dextrin mixing and stirring;
2) pour high temperature furnace internal heating to 800 degree into and make material dissolution, the postcooling caking.
3) cooled complex stirs through hydrolysis, and dries and produce crystallization with 200 degree
The property powder;
4) 100 mesh sieve branches, the packing warehouse-in.
● excellent sugar (yellow)
1) earlier with 12 water magnesium sulfates, 2 aqueous sodium persulfates, glucosan, dextrin, citric acid mixing and stirring;
2) pour high temperature furnace internal heating to 800 degree into and make material dissolution, the postcooling caking.
3) cooled complex stirs through hydrolysis, and dries and produce crystallization with 200 degree
The property powder;
4) 100 mesh sieve branches, the packing warehouse-in.
Beneficial effect
Product of the present invention by plurality of inorganic salt, glucosan, dextrin and citric acid etc. through high temperature
The complex of handling and making.It has stable in properties, PH is stabilized between the 6.5-7, good water solubility, mobile good, color and luster evenly, be difficult for moisture absorption and characteristics such as do not lump.With this product is the powder pre-mixing agent of substrate, nonhygroscopic, do not lump, invariant color, help medicine and absorb in animal body and distribute, to improving bioavailability of medicament and increasing curative effect bigger help is arranged.
The specific embodiment:
For further setting forth water solublity of the present invention pharmaceutic adjuvant for animals, the spy more elaborates in conjunction with the embodiments.
The invention provides a kind of veterinary drug water solublity pharmaceutic adjuvant, it is characterized in that: described veterinary drug water soluble adjuvant is made up of following raw material:
● excellent sugar (white)
1) 12 water magnesium sulfates: 40%
2) 2 aqueous sodium persulfates: 35%
3) glucosan: 15%
4) dextrin: 10%
● excellent sugar (yellow)
1) 12 water magnesium sulfates: 40%
2) 2 aqueous sodium persulfates: 35%
3) glucosan: 15%
4) dextrin: 6%
5) citric acid: 4%
Wherein, 12 water magnesium sulfates, 2 aqueous sodium persulfates and glucosan are primary raw material, dextrin
Be bulking agent, citric acid is a toner.
Described veterinary drug water soluble adjuvant adopts following prepared:
● excellent sugar (white)
1) earlier with 12 water magnesium sulfates, 2 aqueous sodium persulfates, glucosan, dextrin mixing and stirring;
2) pour high temperature furnace internal heating to 800 degree into and make material dissolution, the postcooling caking.
3) cooled complex stirs through hydrolysis, and dries and produce crystallization with 200 degree
The property powder;
4) 100 mesh sieve branches.
5) examination and test of products:
Product is through check, moisture≤6%; 80 order percent of pass are 100%; PH value (5% solution, 25% ℃): 6.5-7.0; Clarity experiment: clarification; Product meets the enterprise product quality standard through check, the packing warehouse-in.
● excellent sugar (yellow)
1) earlier with 12 water magnesium sulfates, 2 aqueous sodium persulfates, glucosan, dextrin, citric acid mixing and stirring;
2) pour high temperature furnace internal heating to 800 degree into and make material dissolution, the postcooling caking.
3) cooled complex stirs through hydrolysis, and dries and produce crystallization with 200 degree
The property powder;
4) 100 mesh sieve branches.
5) examination and test of products:
Product is through check, moisture≤6%; 60 order percent of pass are 100%; PH value (5% solution, 25% ℃): 6.5-7.0; Clarity experiment: clarification; Product meets the enterprise product quality standard through check, the packing warehouse-in.
Product is the complex of being made through high-temperature process by plurality of inorganic salt, glucosan, dextrin and citric acid etc.It has stable in properties, PH is stabilized between the 6.5-7.0, good water solubility, mobile good, color and luster evenly, be difficult for moisture absorption and characteristics such as do not lump.With this product is the powder pre-mixing agent of substrate, nonhygroscopic, do not lump, invariant color, and help medicine and absorb in animal body and distribute, to improving bioavailability of medicament and increasing curative effect bigger help is arranged.
Claims (2)
1. the excellent sugar of veterinary drug water solublity pharmaceutic adjuvant is characterized in that, is made up of by mass ratio following raw material:
12 water magnesium sulfates 40%; 2 aqueous sodium persulfates 35%; Dextran 15 %; Dextrin 10% or dextrin 6% and citric acid 4%.
2. the preparation technology of the excellent sugar of the described veterinary drug water soluble adjuvant of claim 1 comprises:
1) earlier with 12 water magnesium sulfates, 2 aqueous sodium persulfates, glucosan, dextrin, citric acid mixing and stirring;
2) pour high temperature furnace internal heating to 800 degree into and make material dissolution, the postcooling caking;
3) cooled complex stirs through hydrolysis, produces crystalline powder with 200 degree oven dry;
4) 100 mesh sieve branches, the packing warehouse-in.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105328419A CN101979092A (en) | 2010-11-05 | 2010-11-05 | Water-soluble veterinary pharmaceutic adjuvant optimal sugar and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105328419A CN101979092A (en) | 2010-11-05 | 2010-11-05 | Water-soluble veterinary pharmaceutic adjuvant optimal sugar and preparation process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101979092A true CN101979092A (en) | 2011-02-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105328419A Pending CN101979092A (en) | 2010-11-05 | 2010-11-05 | Water-soluble veterinary pharmaceutic adjuvant optimal sugar and preparation process thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106509372A (en) * | 2016-10-09 | 2017-03-22 | 杨松杞 | New water-soluble carrier and preparation method thereof |
| CN111955609A (en) * | 2020-08-29 | 2020-11-20 | 广州承兴生物科技有限公司 | Preparation method of water-soluble auxiliary agent for veterinary drug, aquatic product and feed additive |
| CN114642738A (en) * | 2022-03-23 | 2022-06-21 | 湖南兴镁源科技股份有限公司 | Low-temperature high-solubility water-soluble carrier for livestock and preparation method thereof |
-
2010
- 2010-11-05 CN CN2010105328419A patent/CN101979092A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106509372A (en) * | 2016-10-09 | 2017-03-22 | 杨松杞 | New water-soluble carrier and preparation method thereof |
| CN111955609A (en) * | 2020-08-29 | 2020-11-20 | 广州承兴生物科技有限公司 | Preparation method of water-soluble auxiliary agent for veterinary drug, aquatic product and feed additive |
| CN114642738A (en) * | 2022-03-23 | 2022-06-21 | 湖南兴镁源科技股份有限公司 | Low-temperature high-solubility water-soluble carrier for livestock and preparation method thereof |
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Open date: 20110223 |