CN102860984B - Method for preparing compound sulfachloropyridazine sodium powder - Google Patents
Method for preparing compound sulfachloropyridazine sodium powder Download PDFInfo
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- CN102860984B CN102860984B CN201210358062.0A CN201210358062A CN102860984B CN 102860984 B CN102860984 B CN 102860984B CN 201210358062 A CN201210358062 A CN 201210358062A CN 102860984 B CN102860984 B CN 102860984B
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Abstract
The invention relates to compound sulfachloropyridazine sodium powder, and aims to provide a method for preparing compound sulfachloropyridazine sodium powder for preventing and treating livestock pasteurella infection. The method includes dispensing from 60 to 65 parts of sulfachloropyridazine sodium, from 2 to 4 parts of indometacin potassium, from 10 to 25 parts of suspending agents, from 2 to 4 parts of flavoring agents and the balance acceptable carriers; and then respectively mixing and grinding the components and mixing the components together to obtain the compound sulfachloropyridazine sodium powder. The compound sulfachloropyridazine sodium powder has an exact curative effect for various animals with pasteurellosis and is suitable to be popularized and used in animal husbandary. The sulfachloropyridazine sodium and the indometacin potassium are used compatibly, the indometacin potassium is used as an antibacterial synergist while realizing antibacterial and anti-inflammation effects, and drug effects of a main drug can be strengthened under a synergetic effect. The compound sulfachloropyridazine sodium powder can be orally taken, fed in a mixed manner and absorbed with drinking water effectively, is not easy to cause drug resistance, is safe in long-term healthcare and prevention and treatment, and has good palatability, flowability and suspension water-solubility, and various clinical administration modes of the product and convenience in administration of the product are guaranteed.
Description
Technical field
The present invention relates to a kind of Compound Sulfachorpyrdazine Sodium Powder, also relate to the medicine of control poultry pasteurella infection.
Background technology
Prinzone (Squibb) antimicrobial spectrum is similar to sulfamonomethoxine, is one of sulphonamides that vivo bacteria corrosion action is the strongest, and most of gram positive bacterias and negative bacterium are had to stronger inhibitory action, and it is slower that antibacterial produces drug resistance to this medicine.Blood drug level is high, and acetyl rate is low, is difficult for producing crystalluria.
Bacillus pasteurii disease is a kind of septic infectious disease of the many animals that caused by pasteurella multocida.When the factors such as weather, seasonal variations, long-distance transport and parasitic infection, malnutrition cause animal body resistance to reduce, the health existing pasteurellosis bacillus in animal breath road and tonsil that carries disease germs will become strong toadstool and cause autogenous infection.In addition can be because the feedstuff polluting, water, air, utensil etc. cause exogenous infection through digestive tract, respiratory tract, wound.Because infective agent ubiquity, the normal acute attack of primary disease, the sick fowl of acute can be without any symptom, several lower wings of flapping suddenly death that falls down to the ground, and morbidity animal is in the majority, comparatively serious age with children, and case fatality rate is high.
The medicine that needs the more definite control poultry pasteurella infection of a kind of effect in prior art.Meanwhile, in prior art, do not prevent and treat the Prinzone (Squibb) powder preparation of poultry pasteurella infection yet.
Summary of the invention
Main purpose of the present invention is to provide a kind of for preventing and treating the preparation method of the Compound Sulfachorpyrdazine Sodium Powder of poultry pasteurella infection.
The technical solution adopted in the present invention is: a kind of preparation method of Compound Sulfachorpyrdazine Sodium Powder, is characterized in that:
Formula:
Preparation process:
A, the suspending agent of getting recipe quantity are pulverized, and after pulverizing, cross 80 eye mesh screens, are then uniformly mixed, check the opaque uniformity without decorative pattern without mottle, obtain A powder, standby; The common about 15min of incorporation time;
B, the Prinzone (Squibb) of getting recipe quantity, indomethacin potassium and correctives are pulverized, and after pulverizing, cross 80 eye mesh screens, are then uniformly mixed, and the inspection opaque uniformity without mottle, obtains B powder without decorative pattern; The common about 15min of incorporation time;
C, above-mentioned B powder is added in A powder and stirred by the equivalent method of progressively increasing, then add enough acceptable other carriers to continue to be uniformly mixed, check that the opaque uniformity crosses 80 eye mesh screens without decorative pattern after without mottle, obtain; The common about 15min of incorporation time.
During subpackage, can fill in vinyon bottle, polyethylene plastic bag, loading amount comprises 100g, 200g, 500g etc.
Further, described correctives is sucrose and/or saccharin sodium.
Further, described suspending agent is one or more in silicon Bentonite, sodium citrate, sodium carboxymethyl cellulose.
Further, described suspending agent is the mixture of 5～10 parts of silicon Bentonite, 5～10 parts of sodium citrates, 3～5 parts of sodium carboxymethyl cellulose.
Further, described acceptable carrier is anhydrous glucose or soluble starch.
Product prepared by the inventive method shows following technical advantage in practice:
1, the Bacillus pasteurii disease of many animals is had to definite curative effect, be suitable for promoting the use of in livestock culture.The present invention adopts Prinzone (Squibb) and indomethacin potassium compatibility to use, and in anti-inflammation, indomethacin potassium, as the Trimethoprim of Prinzone (Squibb), can produce the drug effect that synergism strengthens principal agent.Oral, mixed feeding, drinking-water absorb good and are difficult for producing drug resistance, and safety is used in long-term care prevention and treatment.
2, the Compound Sulfachorpyrdazine Sodium Powder of novel process technology preparation has good palatability, mobility and suspendible water solublity, guarantees that this product clinical administration mode is various and convenient.Correctives can be covered the bitterness of Prinzone (Squibb), indomethacin potassium completely, can be directly oral; The adjuvant of the selected suitable particle diameter of prescription makes finished product have good mobility, is convenient to even mixing, and mixed fodder is fed also very safe; Meanwhile, this product is also dry suspension, after dissolving, easily topple over, sedimentation slowly, jolting energy redispersion gently after sedimentation, and the size of the suspended particles after dissolving remains unchanged in long-term storage in water.This has guaranteed again effectiveness and safety that drinking-water is used.
The theoretical foundation of the product that the present invention obtains may be: technical scheme of the present invention has better been brought into play the effect of indomethacin potassium.Indomethacin (Indomethacin) has obvious potent effect to some antibiotic or antimicrobial drug.Because lung tissue is tissue basophil, when pulmonary is inflamed, some antibiotic of indomethacin portability preferentially arrives infection site as the sulfa drugs of high dose, and high concentration is gathered in inflammatory tissue cell peripheral, indomethacin can make sulfa drugs concentration in infected tissue improve 4～8 times, and after coupling, can to reduce by half can be even only 1/4 of positive usual amounts to anti-infectives use amount.This Synergistic Mechanisms is different from the mechanism of action of trimethoprim.Indomethacin also has significant antiinflammatory, antipyretic and analgesic activity.Its antiinflammation is the strongest in anti-inflammation drugs.It is to the high febrile illness antipyretic and anti-inflammatory of pig, chicks thoracic cavity infection, duck infectious bronchitis and poultry pneumonia, hydrothorax and Combination pneumonia have significant adjuvant treatment effect, and this may have obviously potent relevant with antiinflammation with indomethacin.
The specific embodiment
The principal agent Prinzone (Squibb) using in embodiment (anhydride meter content is 99.8%) is purchased from Zhuhai Yuan Cheng medication chemistry company limited; Indomethacin potassium (anhydride meter content is 99.1%) is purchased from Ou Yi Shi Pharmaceutical Group Pharmaceutical Co; Soluble starch, anhydrous glucose, sucrose and saccharin sodium are purchased from Henan navigator's chemical products company limited; Silicon Bentonite, sodium citrate, sodium carboxymethyl cellulose (AR) are purchased from Hua Heng bio tech ltd, Jizhou City.
Embodiment mono-
1, formula
Prinzone (Squibb) 60g, indomethacin potassium 2g, silicon Bentonite 5g, sodium citrate 5g, sodium carboxymethyl cellulose 3g, saccharin sodium 2g, soluble starch 23g.
2: preparation method
The first step: silicon Bentonite, sodium citrate, the sodium carboxymethyl cellulose of getting recipe quantity are pulverized, crosses 80 eye mesh screens after pulverizing, and is then uniformly mixed 15min, obtains the A powder without mottle without decorative pattern;
Second step: Prinzone (Squibb), indomethacin potassium and the saccharin sodium of getting recipe quantity are pulverized, crosses 80 eye mesh screens after pulverizing, and is then uniformly mixed 15min, obtains the B powder without mottle without decorative pattern;
The 3rd step: above-mentioned B powder is added in A powder and stirred by the equivalent method of progressively increasing, then add enough soluble starches to continue to be uniformly mixed 15min.Check to confirm that the opaque uniformity crosses 80 eye mesh screens without decorative pattern after without mottle, obtain Compound Sulfachorpyrdazine Sodium Powder.
Embodiment bis-
1, formula
Prinzone (Squibb) 62.5g, indomethacin potassium 3g, silicon Bentonite 7.5g, sodium citrate 7.5g, sodium carboxymethyl cellulose 4g, sucrose 3g, anhydrous glucose 12.5g.
2: preparation method: identical with method described in embodiment 1, only correctives saccharin sodium is changed to sucrose, other carrier soluble starch is changed to anhydrous glucose.
Embodiment tri-
1, formula
Prinzone (Squibb) 65g, indomethacin potassium 4g, silicon Bentonite 10g, sodium citrate 10g, sodium carboxymethyl cellulose 5g, sucrose 4g, anhydrous glucose 2g.
2: preparation method: identical with method described in embodiment 1, only correctives saccharin sodium is changed to sucrose, other carrier soluble starch is changed to anhydrous glucose.
The stability test of Compound Sulfachorpyrdazine Sodium Powder
1, materials and methods: the Compound Sulfachorpyrdazine Sodium Powder of getting embodiment 1-3, according to appendix medicine stability experimental technique of < < Chinese veterinary pharmacopoeia > > version in 2010, carry out hot and humid high light and accelerate experiment, press commercially available back, 40 ± 2 ℃ of temperature, relative humidity 75 ± 5%, in the medicine stability experimental box of illumination 4500 ± 500LX (Chongqing immortality experimental apparatus factory), place 6 months, at experimental session the 1st, 2, 3, sample respectively once 6 the end of month, character to powder, content, granularity, the outward appearance uniformity, settling volume ratio, redispersibility is investigated.
2, result: as shown in Table 1, Compound Sulfachorpyrdazine Sodium Powder of the present invention is in accelerated test after 6 months, character, content, granularity, the outward appearance uniformity, settling volume ratio, redispersibility have no significant change, have good stability, meet the quality index requirement of < < Chinese veterinary pharmacopoeia > > version in 2010 to dry suspension completely.
The acceleration experimental result of table 1, Compound Sulfachorpyrdazine Sodium Powder of the present invention
Compound Sulfachorpyrdazine Sodium Powder is at veterinary clinic effect
1. materials and methods
1.1 medicine
Compound Sulfachorpyrdazine Sodium Powder of the present invention, adopts the embodiment of the present invention 2 products.
1.2 cases sources: technical staff in Hechuan, the area such as Tongliang County, Tongnan gathers clinically in pasteurella infection natural occurrence case, is respectively duck infectious bronchitis 337 examples, chicken pneumonia 3625 examples, rabbit snuffles 284 examples, piglet pleuropneumonia 235 examples, chicken cholera 2780 examples, baby swine paratyphoid 332 examples, acute fibrinous pleurisy 101 examples of cattle.
1.3 case diagnosis: with natural cases according to epidemiology, clinical symptoms, pathological change, Laboratory Diagnosed.Comprehensive analysis, is diagnosed as pasteurella infection case.
1.4 implementation processes: the technical staff of You Ben seminar carries out case selection and implements treatment, and log.
1.5 results are judged
Usage and dosage: natural cases is used by drinking-water is for oral administration, once measured, every 1kg body weight, pig, cattle 20～30mg, be used in conjunction 6; Chicken, duck, rabbit 20～30mg, be used in conjunction 4.After one week, observe, pay a return visit and record the state of an illness.
Cure: 3～4 future trouble poultry diseases of medication disappear completely, and spirit, body temperature, appetite recover normal, and urine feces is normal.
Effective: 3～4 future trouble poultry diseases of medication disappear substantially, and spirit, body temperature, appetite make moderate progress, and urine feces is normal.
Invalid: 4 future troubles of medication poultry diseases do not disappear, sb.'s illness took a turn for the worse or dead, and urine stool colour, character are undesired.
2. result: compound sulfamethoxazole methoxy pyridazine injection of the present invention has good therapeutic effect as can be seen from Table 2, the effective percentage such as duck infectious bronchitis, chicken pneumonia, rabbit snuffles, piglet pleuropneumonia, chicken cholera, baby swine paratyphoid, the acute fibrinous pleurisy of cattle are reached more than 96.0%, cure rate is all more than 92%, and chicken cholera, chicken pneumonia are had to specially good effect.
Table 2: Compound Sulfachorpyrdazine Sodium Powder clinical therapeutic efficacy statistical table of the present invention
Compound Sulfachorpyrdazine Sodium Powder of the present invention adopts Prinzone (Squibb) and the composite effect that obtains enhancing evident in efficacy of indomethacin potassium.And the consumption of indomethacin potassium is to need to be strict with in formula, can only select at this particular range.
For verifying this technique effect, carry out contrast test.
The formula of comparative example 1: Prinzone (Squibb) 62.5g, indomethacin potassium 1g, silicon Bentonite 7.5g, sodium citrate 7.5g, sodium carboxymethyl cellulose 4g, sucrose 3g, anhydrous glucose 14.5g.
The formula of comparative example 2: Prinzone (Squibb) 62.5g, indomethacin potassium 6g, silicon Bentonite 7.5g, sodium citrate 7.5g, sodium carboxymethyl cellulose 4g, sucrose 3g, anhydrous glucose 9.5g.
The formula of comparative example 3: Prinzone (Squibb) 62.5g, indomethacin potassium 10g, silicon Bentonite 7.5g, sodium citrate 7.5g, sodium carboxymethyl cellulose 4g, sucrose 3g, anhydrous glucose 5.5g.
Preparation method is identical with embodiment 1.
The product of enforcement 2 and the product of comparative example 1,2,3, the curative effect that is used for the treatment of pasteurella infection case by same usage and dosage is as shown in table 3, and visible formula of the present invention has been obtained significant technique effect.
The statistical effect table of table 3 product of the present invention and contrast product clinical treatment chicken pneumonia
Claims (7)
1. a preparation method for Compound Sulfachorpyrdazine Sodium Powder, is characterized in that:
Formula:
60～65 parts of Prinzone (Squibb)s
2～4 parts, indomethacin potassium
10～25 parts of suspending agents
2～4 parts of correctivess
Anhydrous glucose or soluble starch to 100 part;
Preparation process:
A, the suspending agent of getting recipe quantity are pulverized, and after pulverizing, cross 80 eye mesh screens, are then uniformly mixed, check the opaque uniformity without decorative pattern without mottle, obtain A powder, standby;
B, the Prinzone (Squibb) of getting recipe quantity, indomethacin potassium and correctives are pulverized, and after pulverizing, cross 80 eye mesh screens, are then uniformly mixed, and the inspection opaque uniformity without mottle, obtains B powder without decorative pattern, standby;
C, above-mentioned B powder is added in A powder and stirred by the equivalent method of progressively increasing, then add enough anhydrous glucose or soluble starch to continue to be uniformly mixed, check that the opaque uniformity crosses 80 eye mesh screens without decorative pattern after without mottle, obtain.
2. the preparation method of a kind of Compound Sulfachorpyrdazine Sodium Powder according to claim 1, is characterized in that: described correctives is sucrose and/or saccharin sodium.
3. the preparation method of a kind of Compound Sulfachorpyrdazine Sodium Powder according to claim 1, is characterized in that: described suspending agent is multiple in silicon Bentonite, sodium citrate, sodium carboxymethyl cellulose.
4. the preparation method of a kind of Compound Sulfachorpyrdazine Sodium Powder according to claim 3, is characterized in that: described suspending agent is the mixture of 5～10 parts of silicon Bentonite, 5～10 parts of sodium citrates, 3～5 parts of sodium carboxymethyl cellulose.
5. the preparation method of a kind of Compound Sulfachorpyrdazine Sodium Powder according to claim 4, is characterized in that: 60 parts of described Prinzone (Squibb)s, 2 parts, indomethacin potassium, 5 parts of silicon Bentonite, 5 parts of sodium citrates, 3 parts of sodium carboxymethyl cellulose, 2 parts of saccharin sodium, 23 parts of soluble starches.
6. the preparation method of a kind of Compound Sulfachorpyrdazine Sodium Powder according to claim 4, is characterized in that: 62.5 parts of described Prinzone (Squibb)s, 3 parts, indomethacin potassium, 7.5 parts of silicon Bentonite, 7.5 parts of sodium citrates, 4 parts of sodium carboxymethyl cellulose, 3 parts of sucrose, 12.5 parts of anhydrous glucose.
7. the preparation method of a kind of Compound Sulfachorpyrdazine Sodium Powder according to claim 4, is characterized in that: 65 parts of described Prinzone (Squibb)s, 4 parts, indomethacin potassium, 10 parts of silicon Bentonite, 10 parts of sodium citrates, 5 parts of sodium carboxymethyl cellulose, 4 parts of sucrose, 2 parts of anhydrous glucose.
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| CN201310482347.XA Division CN103536601B (en) | 2012-09-24 | 2012-09-24 | Preparation method of medicine used for controlling pasteurella infection of livestock and poultry |
| CN201310482366.2A Division CN103536602B (en) | 2012-09-24 | 2012-09-24 | Medicine used for controlling pasteurella infection of livestock and poultry |
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Non-Patent Citations (4)
| Title |
|---|
| Ralph D.Feigin et.al.无.《Textbook of Pediatric Infectious Diseases》.2004,第2卷3013. * |
| 吲哚美辛在畜禽疾病中的应用;徐艳;《养殖技术顾问》;20101231(第3期);第164页 * |
| 徐艳.吲哚美辛在畜禽疾病中的应用.《养殖技术顾问》.2010,(第3期),第164页. |
| 易本驰等.复方磺胺氯达嗪粉.《养猪科学用药指南》.河南科学技术出版社,2009,196. * |
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