CN111920841A - 高品质红花饮片炮制工艺 - Google Patents

高品质红花饮片炮制工艺 Download PDF

Info

Publication number
CN111920841A
CN111920841A CN202010745159.1A CN202010745159A CN111920841A CN 111920841 A CN111920841 A CN 111920841A CN 202010745159 A CN202010745159 A CN 202010745159A CN 111920841 A CN111920841 A CN 111920841A
Authority
CN
China
Prior art keywords
safflower
weight
decoction pieces
parts
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN202010745159.1A
Other languages
English (en)
Other versions
CN111920841B (zh
Inventor
宋学才
祝涛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anhui Xintai Pharmaceutical Co ltd
Original Assignee
Anhui Xintai Pharmaceutical Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anhui Xintai Pharmaceutical Co ltd filed Critical Anhui Xintai Pharmaceutical Co ltd
Priority to CN202010745159.1A priority Critical patent/CN111920841B/zh
Publication of CN111920841A publication Critical patent/CN111920841A/zh
Application granted granted Critical
Publication of CN111920841B publication Critical patent/CN111920841B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533—Leonurus (motherwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明公开了高品质红花饮片炮制工艺，涉及红花饮片制备技术领域，包括烘干、增强液闷润，冻干、醋炙、蜡封等步骤，本发明通过用增强液闷润红花干品，有效提高红花半成品中的活血有效成分含量，抵消部分加工过程中的损耗，使得红花饮片成品中的有效成分含量提高，同时利用蜂蜡对红花饮片进行包封，固定有效成分，隔绝空气，减少存贮过程中红花饮片的有效成分丧失，提高存贮的红花饮片质量。醋炙可降低红花饮片水溶液的pH值，有效提高红花黄色素的溶出率，提高药效。

Description

高品质红花饮片炮制工艺
技术领域
本发明涉及红花饮片制备领域，特别涉及高品质红花饮片炮制工艺。
背景技术
中药材红花为菊科植物红花的干燥花,别名草红花，具有活血通经、散瘀止痛的功效。从红花中得到的化学成分包括黄酮、生物碱、聚炔、亚精胺、木脂素、倍半萜、有机酸、留醇、烷基二醇、挥发油和多糖等，其中以黄酮类化合物红花黄色素为主要有效成分。红花黄色素为水溶性色素,其色泽随溶液pH的变化而变化,其对光、热和大多金属离子稳，而聚炔类化合物苷元多是油状物形态且较不稳定，置于空气中易发生聚变。挥发油在空气中长期储存或加工过程中极易挥发，导致红花饮片中的挥发油含量较鲜品降低。
红花饮片的炮制方法主要包括烘干，微炒，炒炭，醋炙等，但无论哪种方法，都需要加热干燥，在加热过程中，多种有效成分不可避免的会遭受损失，导致红花的药效降低。红花饮片成品的保存过程中有效成分随时间的推移会发生氧化降解或挥发，也会导致红花的药效降低。
发明内容
本发明所要解决的技术问题：如何提高单位重量红花饮片成品中的有效成分含量，并在红花饮片制成后，长时间保持饮片中的有效成分不丢失。
为解决上述技术问题，本发明提供以下的技术方案：
高品质红花饮片炮制工艺，具体步骤如下：
(1)将新采收的红花去萼片，烘干得红花干品；
(2)将红花干品用增强液闷润12h，冻干得干品二，所述红花干品与闷润增强液的重量比为1:5～8。
(3)将干品二加酿造食用醋喷匀并完全吸收后，以微火炒至焦红色得干品三；
(4)将干品三进行蜡封后的红花饮片。
优选地，所述干品二与醋的重量比为10:1～3，所述微火的温度为110～130℃。
优选地，所述蜡封的具体步骤为：将蜂蜡加热融化为液体状停止加热，将干品三加入热蜡液中，搅拌均匀后静置凝固，切片即可，所述蜂蜡与干品三的重量比为3:2～8。
优选地，所述醋为米醋，果醋、白醋中的一种。
优选地，所述增强液的制备方法如下：
(1)将活血化瘀中药材按1:10～20重量比加水煮沸，采用蒸汽回流提取法提取油性挥发液；
(2)提取完成后将剩余的水溶液过滤，除渣，将滤液采用大孔树脂进行红花黄色素的提取，提取获得的红花黄色素原液与油性挥发液混合后即得增强液。
优选地，所述活血化瘀中药材为红花干品。
优选地，所述活血化瘀中药材为20重量份三七、10重量份益母草、10重量份丹参、20重量份川芎、15重量份当归、25重量份丹皮、5重量份生蒲黄、5重量份乳香、200重量份红花。
本发明获得的有益效果：
通过用增强液闷润红花干品，有效提高红花半成品中的活血有效成分含量，抵消部分加工过程中的损耗，使得红花饮片成品中的有效成分含量提高，同时利用蜂蜡对红花饮片进行包封，固定有效成分，隔绝空气，减少存贮过程中红花饮片的有效成分丧失，提高存贮的红花饮片质量。醋炙可降低红花饮片水溶液的pH值，有效提高红花黄色素的溶出率，提高药效。
具体实施方式
下面通过对实施例的描述，对本发明的具体实施方式作进一步详细的说明，以帮助本领域的技术人员对本发明的发明构思、技术方案有更完整、准确和深入的理解。
实施例1：按如下方法制备高品质红花饮片，具体步骤如下：
(1)将新采收的红花去萼片，烘干得红花干品；
将红花干品用增强液闷润12h，冻干得干品二，所述红花干品与闷润增强液的重量比为1:5～8。所述增强液的制备方法如下：
(A)将红花干品按料液比1:10重量比加水煮沸，采用蒸汽回流提取法提取油性挥发液；提取溶媒为纯水；温度60℃；提取1次，每次10min。
(B)提取完成后将剩余的水溶液过滤，除渣，将滤液采用大孔树脂H103进行红花黄色素的提取，上柱样品量与树脂量用量之比为1∶10(W：V)，洗脱速度1.0mL/min·cm2。提取获得的红花黄色素原液与油性挥发液混合后即得增强液。
(2)将干品二加酿造食用醋喷匀并完全吸收后，以微火炒至焦红色得干品三；所述干品二与米醋的重量比为10:1，所述微火的温度为110℃。
(3)将干品三进行蜡封后的红花饮片，所述蜡封的具体步骤为：将蜂蜡加热融化为液体状停止加热，将干品三加入热蜡液中，搅拌均匀后静置凝固，切片即可，所述蜂蜡与干品三的重量比为3:2。
实施例2：按如下方法制备高品质红花饮片，具体步骤如下：
(1)将新采收的红花去萼片，烘干得红花干品；
(2)将红花干品用增强液闷润12h，冻干得干品二，所述红花干品与闷润增强液的重量比为1:8。所述增强液的制备方法如下：
(A)将20重量份三七、10重量份益母草、10重量份丹参、20重量份川芎、15重量份当归、25重量份丹皮、5重量份生蒲黄、5重量份乳香、200重量份红花称重配制后按料液比1:20重量比加水煮沸，采用蒸汽回流提取法提取油性挥发液；提取溶媒为pH＝3的酸水；温度70℃；提取4次，每次4h。
(B)提取完成后将剩余的水溶液过滤，除渣，将滤液采用大孔树脂H103进行红花黄色素的提取，上柱样品量与树脂量用量之比为1∶15(W∶V),洗脱速度1.0mL/min·cm2。提取获得的红花黄色素原液与油性挥发液混合后即得增强液。
(3)将干品二加酿造食用醋喷匀并完全吸收后，以微火炒至焦红色得干品三；所述干品二与果醋的重量比为10:3，所述微火的温度为130℃。
(4)将干品三进行蜡封后的红花饮片，所述蜡封的具体步骤为：将蜂蜡加热融化为液体状停止加热，将干品三加入热蜡液中，搅拌均匀后静置凝固，切片即可，所述蜂蜡与干品三的重量比为3:8。
实施例3：按如下方法制备高品质红花饮片，具体步骤如下：
(1)将新采收的红花去萼片，烘干得红花干品；将红花干品用增强液闷润24h，冻干得干品二，所述红花干品与闷润增强液的重量比为1:6.5。所述增强液的制备方法如下：
(A)将红花干品按料液比1:15重量比加水煮沸，采用蒸汽回流提取法提取油性挥发液；提取溶媒为pH＝3的酸水；温度65℃；提取3次，每次1h。
(B)提取完成后将剩余的水溶液过滤，除渣，将滤液采用大孔树脂H103进行红花黄色素的提取，上柱样品量与树脂量用量之比为1∶10(W∶V),洗脱速度1.0mL/min·cm2。提取获得的红花黄色素原液与油性挥发液混合后即得增强液。
(2)将干品二加酿造食用醋喷匀并完全吸收后，以微火炒至焦红色得干品三；所述干品二与白醋的重量比为10:2，所述微火的温度为120℃。
(3)将干品三进行蜡封后的红花饮片，所述蜡封的具体步骤为：将蜂蜡加热融化为液体状停止加热，将干品三加入热蜡液中，搅拌均匀后静置凝固，切片即可，所述蜂蜡与干品三的重量比为3:5。
对照实施例1：其余均与实施例1相同，不同之处在于未进行蜡封步骤。
对照实施例2：其余均与实施例2相同，不同之处在于未进行增强液闷润步骤。
将实施例1～3及对照实施例1、2新制的红花饮片分别采用纯水煮制30min，料液比1:30，过滤取下层水溶液得粗提液，将粗提液作为样品，采用HPLC测定其中的有效成分含量，采用GC测定挥发油含量，结果如下：
表1红花饮片中的有效成分含量测定结果
组别 红花黄色素(mg/mL) 聚炔(μg/mL) 挥发油(μg/mL)
实施例1 110.3 45.9 43.2
实施例2 121.1 65.7 40.4
实施例3 117.4 53.2 38.7
对照实施例1 123.2 64.8 37.5
对照实施例2 37.4 11.6 2.8
表1结果显示，采用增强液闷润后制备的红花饮片，其红花黄色素、聚炔、挥发油的含量或存留量显著提高。主要是由于增强液中含有大量的红花黄色素、聚炔、挥发油成分，抵消加工过程中的损耗，使得主要药效成分在热加工后仍有提高。蜡封步骤对新制红花饮片中有效成分含量几乎没有影响。
将实施例2及对照实施例1新制的红花饮片分别置于37℃，空气接触条件下，放置6、12、24个月后采样测定其中的有效成分含量，结果如下：
表2贮存时间对红花饮片有效成分的影响
Figure BDA0002608119460000041
表1和表2结果显示没有进行蜡封时，挥发油的降低速度最快，其次为聚炔，挥发油主要是挥发至空气中而丧失，而聚炔则是由于在空气中聚变而丧失，红花黄色素在长时间的贮存后，也有较大的损失，因此，相同贮存条件下，蜡封可隔绝饮片与空气，使得饮片中的有效成分可长期存留与红花饮片中，显著提高了饮片的保藏时间，提高饮片的加工经济效益。
综上所述，通过用增强液闷润红花干品，有效提高红花半成品中的活血有效成分含量，抵消部分加工过程中的损耗，使得红花饮片成品中的有效成分含量提高，同时利用蜂蜡对红花饮片进行包封，固定有效成分，隔绝空气，减少存贮过程中红花饮片的有效成分丧失，提高存贮的红花饮片质量。醋炙可降低红花饮片水溶液的pH值，有效提高红花黄色素的溶出率，提高药效。
以上实施例仅为说明本发明的技术思想，不能以此限定本发明的保护范围，凡是按照本发明提出的技术思想，在技术方案基础上所做的任何改动，均落入本发明保护范围之内；本发明未涉及的技术均可通过现有技术加以实现。

Claims (7)

1.高品质红花饮片炮制工艺，其特征在于，具体步骤如下：
(1)将新采收的红花去萼片，烘干得红花干品；
(2)将红花干品用增强液闷润12h，冻干得干品二，所述红花干品与闷润增强液的重量比为1:5～8。
(3)将干品二加酿造食用醋喷匀并完全吸收后，以微火炒至焦红色得干品三；
(4)将干品三进行蜡封后的红花饮片。
2.根据权利要求1中所述的高品质红花饮片炮制工艺，其特征在于：所述干品二与醋的重量比为10:1～3，所述微火的温度为110～130℃。
3.根据权利要求1中所述的高品质红花饮片炮制工艺，其特征在于：所述蜡封的具体步骤为：将蜂蜡加热融化为液体状停止加热，将干品三加入热蜡液中，搅拌均匀后静置凝固，切片即可，所述蜂蜡与干品三的重量比为3:2～8。
4.根据权利要求1中所述的高品质红花饮片炮制工艺，其特征在于：所述醋为米醋，果醋、白醋中的一种。
5.根据权利要求4中所述的高品质红花饮片炮制工艺，其特征在于：所述增强液的制备方法如下：
(1)将活血化瘀中药材按1:10～20重量比加水煮沸，采用蒸汽回流提取法提取油性挥发液；
(2)提取完成后将剩余的水溶液过滤，除渣，将滤液采用大孔树脂进行红花黄色素的提取，提取获得的红花黄色素原液与油性挥发液混合后即得增强液。
6.根据权利要求5中所述的高品质红花饮片炮制工艺，其特征在于：所述活血化瘀中药材为红花干品。
7.根据权利要求5中所述的高品质红花饮片炮制工艺，其特征在于：所述活血化瘀中药材为20重量份三七、10重量份益母草、10重量份丹参、20重量份川芎、15重量份当归、25重量份丹皮、5重量份生蒲黄、5重量份乳香、200重量份红花。
CN202010745159.1A 2020-07-29 2020-07-29 一种红花饮片炮制工艺 Active CN111920841B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010745159.1A CN111920841B (zh) 2020-07-29 2020-07-29 一种红花饮片炮制工艺

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202010745159.1A CN111920841B (zh) 2020-07-29 2020-07-29 一种红花饮片炮制工艺

Publications (2)

Publication Number Publication Date
CN111920841A true CN111920841A (zh) 2020-11-13
CN111920841B CN111920841B (zh) 2022-02-15

Family

ID=73315935

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202010745159.1A Active CN111920841B (zh) 2020-07-29 2020-07-29 一种红花饮片炮制工艺

Country Status (1)

Country Link
CN (1) CN111920841B (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112569269A (zh) * 2020-12-30 2021-03-30 国药集团广东环球制药有限公司 一种酒红花饮片及其炮制方法
CN113975306A (zh) * 2021-09-18 2022-01-28 大理万福思源农业开发有限公司 一种红花花果茶的制作方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1077383A (zh) * 1993-01-06 1993-10-20 江西中医学院附属医院 中药的制备方法
CN108310034A (zh) * 2018-04-04 2018-07-24 安徽颐生堂中药饮片有限公司 一种红花饮片及其制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1077383A (zh) * 1993-01-06 1993-10-20 江西中医学院附属医院 中药的制备方法
CN108310034A (zh) * 2018-04-04 2018-07-24 安徽颐生堂中药饮片有限公司 一种红花饮片及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张翠英等: "醋红花炮制工艺的优选 ", 《中成药》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112569269A (zh) * 2020-12-30 2021-03-30 国药集团广东环球制药有限公司 一种酒红花饮片及其炮制方法
CN113975306A (zh) * 2021-09-18 2022-01-28 大理万福思源农业开发有限公司 一种红花花果茶的制作方法

Also Published As

Publication number Publication date
CN111920841B (zh) 2022-02-15

Similar Documents

Publication Publication Date Title
KR100794447B1 (ko) 발모촉진제 및 그의 제조방법
EP2003988B1 (en) Natural plant extract composition for prevention and recovery of hyperlipidemia and stroke, natural tea containing the same as active ingredient and method for preparing the natural tea
CN102934721B (zh) 端午茶凉茶饮料及其制备方法
CN104982599A (zh) 一种植物凉茶浓缩液及低糖植物凉茶饮料
CN111920841B (zh) 一种红花饮片炮制工艺
KR100707345B1 (ko) 증숙 도라지
KR101751211B1 (ko) 남성 성기능 개선용 조성물, 이를 유효성분으로 포함하는 남성 성기능 개선용 기능성 식품 조성물 및 이의 제조방법
KR100678869B1 (ko) 지구자나무를 포함한 생약재 추출물을 함유하는 음료의제조방법
CN106720685A (zh) 一种青钱柳速溶茶及其制备方法
CN107233599B (zh) 可快速去除空气内金属污染物的空气净化剂
CN111184785A (zh) 从玫瑰花中提取黄酮类物质的方法
CN106620616A (zh) 一种防脱发、生发的药物组合物及其制剂
CN104705456A (zh) 一种植物复合凉茶及其制备方法
CN114600999A (zh) 一种功能性咖啡保健饮品及其制备方法
CN113197957A (zh) 一种姜半夏的炮制方法
CN103315101B (zh) 元宝枫芽茶及其制备工艺
CN106212783A (zh) 有机茶叶葛藤叶薯叶配方红茶
CN105961813A (zh) 一种罗汉果压片糖果及其制备方法
KR101684869B1 (ko) 세리포리아락세라타 추출물 함유 목욕용제
KR100708214B1 (ko) 황금성분 함유 쌀의 제조방법
KR20210016966A (ko) 산양산삼 고함유 음료조성물 및 그 제조방법
KR102404179B1 (ko) 대추차 제조방법
KR102494072B1 (ko) 생약 추출물을 포함하는 우울감 개선 또는 예방용 조성물 및 이의 제조방법
CN110192586B (zh) 一种石榴复合保健茶及其制备方法
KR101009957B1 (ko) 원적외선 조사를 이용한 로즈마린산 함량이 증가된 로즈마리의 제조방법

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant