CN111918969B - 新型水解酶和利用该酶的(1s,2s)-1-烷氧基羰基-2-乙烯基环丙烷羧酸的制造方法 - Google Patents

新型水解酶和利用该酶的(1s,2s)-1-烷氧基羰基-2-乙烯基环丙烷羧酸的制造方法 Download PDF

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CN111918969B
CN111918969B CN201980022337.3A CN201980022337A CN111918969B CN 111918969 B CN111918969 B CN 111918969B CN 201980022337 A CN201980022337 A CN 201980022337A CN 111918969 B CN111918969 B CN 111918969B
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CN111918969A (zh
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吉田丰和
石田浩一
三宅良磨
井浦崇敦
川端润
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API Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)

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  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201980022337.3A 2018-03-30 2019-03-29 新型水解酶和利用该酶的(1s,2s)-1-烷氧基羰基-2-乙烯基环丙烷羧酸的制造方法 Active CN111918969B (zh)

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JP2018070188 2018-03-30
JP2018-070188 2018-03-30
PCT/JP2019/013926 WO2019189724A1 (ja) 2018-03-30 2019-03-29 新規加水分解酵素及びそれを利用した（１ｓ，２ｓ）－１－アルコキシカルボニル－２－ビニルシクロプロパンカルボン酸の製造方法

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CN111918969B true CN111918969B (zh) 2024-11-19

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WO (1) WO2019189724A1 (https=)

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Publication number Priority date Publication date Assignee Title
CN110283804A (zh) * 2019-07-18 2019-09-27 江苏省农业科学院 酯酶基因及编码蛋白与应用
CN110643625A (zh) * 2019-09-23 2020-01-03 上海应用技术大学 一种重组表达质粒与基因工程菌及(4s,5r)-半酯的制备方法

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CS199542B2 (en) 1970-07-13 1980-07-31 Giacomo Cevales Process for thermal treatment of refractory material prepared by the heat for increasing corrosion resistance
JPS57183799A (en) 1981-04-17 1982-11-12 Kyowa Hakko Kogyo Co Ltd Novel plasmid
DE60323215D1 (de) * 2002-03-19 2008-10-09 Mitsubishi Chem Corp Neue carbonylreduktase, diese codierendes gen und verfahren zur produktion optisch-aktiver alkohole damit
CA3007908A1 (en) 2003-03-07 2005-04-14 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
JP2005034025A (ja) 2003-07-18 2005-02-10 Mitsubishi Pharma Corp 大腸菌での異種遺伝子発現を促進させるプラスミドベクター、組換え大腸菌、該組換え大腸菌を用いた化学物質製造法及び組換えタンパク質の製造法
CN102834370B (zh) 2010-02-16 2016-11-23 株式会社Api 1-氨基-1-烷氧基羰基-2-乙烯基环丙烷的制备方法
US9029107B2 (en) 2010-08-31 2015-05-12 Api Corporation Hydrolase protein
US20140142337A1 (en) * 2011-06-21 2014-05-22 Mitsubishi Gas Chemical Company, Inc. 1-amino-2-vinylcyclopropane carboxylic acid amide and salt thereof, and method for producing same
EP2796562A4 (en) 2011-12-19 2015-11-25 Sumitomo Chemical Co METHOD FOR PRODUCING AN OPTICALLY ACTIVE SUBSTITUTED AMINO ACID
JP2018070188A (ja) 2016-10-25 2018-05-10 キヤノン株式会社 緩衝部材、梱包容器、及び画像形成装置用の梱包容器

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
alpha/beta hydrolase [Microbacterium chocolatum];NCBI;GenBank;20150903;WP_053548180.1 *
alpha/beta hydrolase [Pseudonocardia dioxanivorans];NCBI;GenBank;20130518;WP_013673631 *
alpha/beta hydrolase [Rhodococcus sp. 06-621-2];Savory E.A.等;GenBank;20170818;OZC62876.1 *

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US11572551B2 (en) 2023-02-07
EP3778898A1 (en) 2021-02-17
US20230323317A1 (en) 2023-10-12
JPWO2019189724A1 (ja) 2021-04-01
CN111918969A (zh) 2020-11-10
US12258593B2 (en) 2025-03-25
WO2019189724A1 (ja) 2019-10-03
JP7458680B2 (ja) 2024-04-01
US20210024905A1 (en) 2021-01-28
EP3778898A4 (en) 2022-02-09

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