CN111802536A - Feed additive for large yellow croaker female fish and preparation method and application thereof - Google Patents
Feed additive for large yellow croaker female fish and preparation method and application thereof Download PDFInfo
- Publication number
- CN111802536A CN111802536A CN202010762492.3A CN202010762492A CN111802536A CN 111802536 A CN111802536 A CN 111802536A CN 202010762492 A CN202010762492 A CN 202010762492A CN 111802536 A CN111802536 A CN 111802536A
- Authority
- CN
- China
- Prior art keywords
- large yellow
- yellow croaker
- parts
- feed additive
- female fish
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241001596950 Larimichthys crocea Species 0.000 title claims abstract description 107
- 241000251468 Actinopterygii Species 0.000 title claims abstract description 96
- 239000003674 animal food additive Substances 0.000 title claims abstract description 63
- 238000002360 preparation method Methods 0.000 title claims abstract description 55
- 241000411851 herbal medicine Species 0.000 claims abstract description 41
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims abstract description 36
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims abstract description 36
- 235000021283 resveratrol Nutrition 0.000 claims abstract description 36
- 229940016667 resveratrol Drugs 0.000 claims abstract description 36
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 30
- 235000009411 Rheum rhabarbarum Nutrition 0.000 claims abstract description 29
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 21
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 21
- 235000011477 liquorice Nutrition 0.000 claims abstract description 21
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 15
- 241000037740 Coptis chinensis Species 0.000 claims abstract description 12
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims abstract description 9
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims abstract description 9
- 229940010454 licorice Drugs 0.000 claims abstract description 9
- 241000219061 Rheum Species 0.000 claims description 27
- 230000002710 gonadal effect Effects 0.000 claims description 23
- 241000218202 Coptis Species 0.000 claims description 18
- 235000002991 Coptis groenlandica Nutrition 0.000 claims description 18
- 239000004113 Sepiolite Substances 0.000 claims description 17
- 235000019355 sepiolite Nutrition 0.000 claims description 17
- 229910052624 sepiolite Inorganic materials 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 11
- 238000011161 development Methods 0.000 claims description 10
- 238000010298 pulverizing process Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 8
- 239000012674 herbal formulation Substances 0.000 claims description 3
- 241000202807 Glycyrrhiza Species 0.000 claims 2
- 239000006052 feed supplement Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 230000004083 survival effect Effects 0.000 abstract description 14
- 230000004584 weight gain Effects 0.000 abstract description 14
- 235000019786 weight gain Nutrition 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 11
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract description 7
- 238000009395 breeding Methods 0.000 abstract description 7
- 230000001488 breeding effect Effects 0.000 abstract description 7
- 230000008901 benefit Effects 0.000 abstract description 5
- 230000026109 gonad development Effects 0.000 abstract description 5
- 210000002149 gonad Anatomy 0.000 abstract description 4
- 238000009776 industrial production Methods 0.000 abstract description 3
- 244000299790 Rheum rhabarbarum Species 0.000 abstract 2
- 238000012360 testing method Methods 0.000 description 20
- 230000000052 comparative effect Effects 0.000 description 18
- 239000000203 mixture Substances 0.000 description 10
- 230000018109 developmental process Effects 0.000 description 9
- 239000002245 particle Substances 0.000 description 5
- 230000001568 sexual effect Effects 0.000 description 4
- 240000004980 Rheum officinale Species 0.000 description 3
- 235000008081 Rheum officinale Nutrition 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 235000014590 basal diet Nutrition 0.000 description 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 210000004907 gland Anatomy 0.000 description 2
- 230000033822 gland development Effects 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 229960004051 menadione sodium bisulfite Drugs 0.000 description 2
- XDPFHGWVCTXHDX-UHFFFAOYSA-M menadione sodium sulfonate Chemical compound [Na+].C1=CC=C2C(=O)C(C)(S([O-])(=O)=O)CC(=O)C2=C1 XDPFHGWVCTXHDX-UHFFFAOYSA-M 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229910021580 Cobalt(II) chloride Inorganic materials 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 235000019733 Fish meal Nutrition 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 230000003260 anti-sepsis Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229910052927 chalcanthite Inorganic materials 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000008845 cholagoga Substances 0.000 description 1
- 229940124571 cholagogue Drugs 0.000 description 1
- 239000002734 clay mineral Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229960002104 cyanocobalamin Drugs 0.000 description 1
- 235000000639 cyanocobalamin Nutrition 0.000 description 1
- 239000011666 cyanocobalamin Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 235000021321 essential mineral Nutrition 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 239000004467 fishmeal Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
- 229910000357 manganese(II) sulfate Inorganic materials 0.000 description 1
- 229910052603 melanterite Inorganic materials 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- 238000009304 pastoral farming Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001543 purgative effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229940083466 soybean lecithin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229960000344 thiamine hydrochloride Drugs 0.000 description 1
- 235000019190 thiamine hydrochloride Nutrition 0.000 description 1
- 239000011747 thiamine hydrochloride Substances 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 239000011686 zinc sulphate Substances 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K61/00—Culture of aquatic animals
- A01K61/10—Culture of aquatic animals of fish
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Marine Sciences & Fisheries (AREA)
- Inorganic Chemistry (AREA)
- Environmental Sciences (AREA)
- Insects & Arthropods (AREA)
- Birds (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Physiology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Abstract
The invention discloses a large yellow croaker female fish feed additive and a preparation method and application thereof, belonging to the technical field of large yellow croaker feeds. According to the parts by weight, each 100 parts of feed additive comprises 10-20 parts of Chinese herbal medicine preparation, 0.5-2.5 parts of resveratrol and the balance of carrier; the Chinese herbal medicine preparation is prepared with rhubarb, Chinese goldthread and licorice. The feed additive is used for breeding large yellow croaker female fish by matching the rhubarb, the coptis chinensis, the liquorice and the resveratrol, so that the gonad index of the large yellow croaker female fish can be effectively reduced, the good effect of inhibiting the gonad development of the large yellow croaker female fish is achieved, the weight gain rate and the survival rate of the large yellow croaker female fish can be improved, and the breeding benefit is greatly improved. The preparation method of the feed additive is simple and rapid, and can be used for industrial production.
Description
Technical Field
The invention relates to the technical field of large yellow croaker feed, and particularly relates to a large yellow croaker female feed additive and a preparation method and application thereof.
Background
The large yellow croaker is one of the most important economic fishes in the southeast coast of China, is also a marine fish with the highest culture yield at present in China, and is popular with consumers in domestic and foreign markets. At present, female large yellow croakers circulating in the market are almost artificially cultured, and because the cost and risk of common cage culture are relatively low, the common cage culture mode distributed offshore is the most common at present.
However, the gonad of the large yellow croaker is too fast due to the common cage culture mode, and the breeding farm (household) finds that about 200g of some female fishes can see abdominal distension. In the fish gonad development process, energy generated by fish metabolism is mainly consumed in the growth of sexual cells, the contents of protein and fat in muscles and livers are reduced continuously from the quick growth of the sexual cells to the completion of the discharge of the sexual cells, the normal growth of the sexual cells is seriously influenced, and the yield is reduced; in addition, the female fish matures before the reproductive season and can not lay eggs due to condition limitation, so that the death rate of the cultured fish is increased, and huge economic loss is brought to the culture of the large yellow croaker female fish.
In view of this, the invention is particularly proposed.
Disclosure of Invention
One of the purposes of the invention comprises providing a feed additive for large yellow croaker female fish, which not only can effectively reduce the gonadal index of the large yellow croaker female fish and play a good role in inhibiting the gonadal development of the large yellow croaker female fish, but also can improve the weight gain rate and the survival rate of the large yellow croaker female fish and greatly improve the culture benefit.
The second purpose of the invention is to provide a preparation method of the large yellow croaker female fish feed additive, which is simple and rapid and can be industrially produced.
The invention also provides the application of the feed additive for the large yellow croaker female fish, for example, the feed additive is used for inhibiting the gonad development of the large yellow croaker female fish.
The application is realized as follows:
according to the first aspect, the application provides a feed additive for large yellow croaker female fish, wherein each 100 parts of the feed additive for large yellow croaker female fish comprises 10-20 parts of Chinese herbal medicine preparation, 0.5-2.5 parts of resveratrol and the balance of carrier in parts by weight; the Chinese herbal medicine preparation is prepared with rhubarb, Chinese goldthread and licorice.
In a preferred embodiment, each 100 parts of the feed additive for large yellow croaker female fish comprises 15-20 parts of Chinese herbal medicine preparation, 1.5-2.5 parts of resveratrol and the balance of carrier.
In a more preferred embodiment, every 100 parts of the feed additive for the large yellow croaker and the female fish comprises 15 parts of the Chinese herbal medicine preparation, 1.5 parts of resveratrol and the balance of a carrier.
In an optional embodiment, the Chinese herbal medicine preparation comprises the following raw materials in a weight ratio of 4: 2: 1, rhubarb, coptis and liquorice.
In an alternative embodiment, the carrier comprises sepiolite.
In a second aspect, the present application provides a method for preparing the feed additive for female large yellow croakers, which comprises the following steps: mixing the Chinese herbal medicine preparation, the resveratrol and the carrier according to the proportion.
In an alternative embodiment, a method of preparing a herbal formulation comprises: pulverizing the rhubarb, the coptis root and the licorice and mixing.
In an alternative embodiment, micronization is used for the pulverization.
In an alternative embodiment, the powder is passed through a 100-120 mesh screen after pulverization.
In an alternative embodiment, the composition further comprises dried rhubarb, coptis root and licorice before crushing.
In an alternative embodiment, the drying temperature of the rhubarb, the coptis root and the liquorice is 60-65 ℃, and the drying time is 8-9 h.
In a third aspect, the application provides the application of the feed additive for female large yellow croakers in inhibiting the gonadal development of the large yellow croakers.
The beneficial effect of this application includes:
according to the feed additive for the large yellow croaker female fish, the rheum officinale, the coptis chinensis and the liquorice are compounded, and the resveratrol is added for breeding the large yellow croaker female fish, so that the gonadal index of the large yellow croaker female fish can be effectively reduced, a good effect of inhibiting the gonadal development of the large yellow croaker female fish is achieved, the weight gain rate and the survival rate of the large yellow croaker female fish can be improved, and the breeding benefit is greatly improved. The preparation method of the feed additive is simple and rapid, and can be used for industrial production.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
The large yellow croaker female fish feed additive provided by the present application, the preparation method and the application thereof are specifically explained below.
The application provides a large yellow croaker female feed additive, wherein each 100 parts of the large yellow croaker female feed additive comprises, by weight, 10-20 parts of a Chinese herbal medicine preparation, 0.5-2.5 parts of resveratrol and the balance of a carrier. Wherein the Chinese herbal medicine preparation comprises radix et rhizoma Rhei, Coptidis rhizoma and Glycyrrhrizae radix.
Optionally, the Chinese herbal medicine preparation in each 100 parts of the feed additive for large yellow croaker female fish can be 10 parts, 12 parts, 15 parts, 18 parts or 20 parts, and the like, and the resveratrol can be 0.5 part, 1 part, 1.5 parts, 2 parts or 2.5 parts, and the like. It is worth mentioning that the dosage of the Chinese herbal medicine preparation and the resveratrol can be freely combined according to the respective ranges.
In a preferred embodiment, each 100 parts of the feed additive for large yellow croaker female fish comprises 15-20 parts of Chinese herbal medicine preparation, 1.5-2.5 parts of resveratrol and the balance of carrier.
In a more preferred embodiment, every 100 parts of the feed additive for the large yellow croaker and the female fish comprises 15 parts of the Chinese herbal medicine preparation, 1.5 parts of resveratrol and the balance of a carrier.
In an optional embodiment, the Chinese herbal medicine preparation comprises the following raw materials in a weight ratio of 4: 2: 1, rhubarb, coptis and liquorice.
The rhubarb, the coptis root and the liquorice are compounded according to the proportion and are mixed with the resveratrol according to the proportion, so that the excellent effects of inhibiting the gonadal development of the large yellow croaker female fish and improving the weight gain rate and the survival rate of the large yellow croaker female fish can be achieved.
In an alternative embodiment, the support may comprise, for example, sepiolite.
In the large yellow croaker female fish feed additive, the large yellow croaker is a representative of the traditional purgative drugs and has the effects of clearing heat, purging fire, cooling blood, detoxifying and the like; it is used clinically for constipation, hemostasis, antisepsis and anti-inflammation, cholagogue, improving renal function, etc. However, in the application, the rhubarb is mainly used for reducing the gonadal index of female large yellow croakers and inhibiting the gonadal development of the female large yellow croakers.
However, the tanning substances contained in the rhubarb have certain toxicity, the growth performance of the large yellow croaker female fish can be reduced only by adding the rhubarb, and the growth performance of the large yellow croaker female fish is obviously improved and the toxicity is reduced after the rhubarb is matched with the liquorice and the coptis chinensis.
Further, the inventor creatively discovers that the Chinese herbal medicine preparation is matched with resveratrol, and the coptis chinensis and the resveratrol in the Chinese herbal medicine preparation are compounded to increase the metabolic activity of lipase, reduce the fat content of the fish gonad, promote the fat degradation and inhibit the deposition of fat in the gonad (namely reduce the deposition of ovarian fat), thereby inhibiting the gonad development of fish.
The sepiolite is used as a fibrous magnesium-rich clay mineral, has large surface area and good adsorbability and fluidity, and can be used as a carrier in a feed additive to ensure that all components are uniformly distributed and flow freely. When the feed additive is used for preparing the large yellow croaker female feed, the particle hardness of the feed is improved, the feed is easy to granulate, and the stability of the particle feed in water is prolonged. In addition, the feed also contains rich animal essential minerals and trace elements, and is favorable for promoting the growth of large yellow croaker female fish.
In summary, the components are matched according to a specific proportion, so that the compound feed not only has the functions of the components, but also can reduce toxicity and jointly play the roles of inhibiting the gonadal development of the large yellow croaker female fish and promoting the growth of the large yellow croaker female fish through the coordination and complementation and the compounding effect among the components.
In addition, the application also provides a preparation method of the feed additive for the large yellow croaker female fish, which comprises the following steps: mixing the Chinese herbal medicine preparation, the resveratrol and the carrier according to the proportion. Specifically, the Chinese herbal medicine preparation, the resveratrol and the carrier can be sequentially mixed step by step.
In an alternative embodiment, a method of preparing a herbal formulation may comprise: pulverizing the rhubarb, the coptis root and the licorice and mixing.
Wherein the pulverization can be carried out by micronization. After being crushed, the powder can pass through a sieve of 100 meshes and 120 meshes.
In an alternative embodiment, the composition further comprises dried rhubarb, coptis root and licorice before crushing.
For reference, the drying temperature of the rhubarb, the coptis root and the liquorice can be 60-65 ℃, such as 60 ℃, 62 ℃ or 65 ℃, and the drying time can be 8-9h, such as 8h, 8.5h or 9 h.
It should be noted that in the specific operation, the rhubarb, the coptis root and the liquorice can be respectively dried, crushed and sieved, and then mixed. Or mixing, drying, pulverizing, and sieving.
In addition, the preparation method is simple in process, easy to operate and suitable for industrial preparation.
Furthermore, the application also provides an application of the feed additive for the large yellow croaker female fish, which is used for inhibiting the gonad development of the large yellow croaker female fish.
The feed can be used for preparing the feed for the large yellow croaker female fish, and is fed when 70-100g of the large yellow croaker female fish is fed once every two weeks, so that the energy waste can be reduced to the maximum extent.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The embodiment provides a large yellow croaker female fish feed additive, wherein each 100 parts of the large yellow croaker female fish feed additive comprises, by weight, 10 parts of a Chinese herbal medicine preparation, 0.5 part of resveratrol and the balance of sepiolite. Wherein, the Chinese herbal medicine preparation is prepared from the following raw materials in parts by weight of 4: 2: 1, rhubarb, coptis and liquorice.
The preparation method of the feed additive for the large yellow croaker female fish comprises the following steps:
mixing radix et rhizoma Rhei, Coptidis rhizoma and Glycyrrhrizae radix, oven drying in 60 deg.C oven for 8 hr, micronizing, and sieving with 100 mesh sieve to obtain Chinese medicinal preparation.
Mixing the Chinese herbal medicine preparation, resveratrol and sepiolite step by step according to the proportion to obtain the large yellow croaker female fish feed additive.
Example 2
This example differs from example 1 only in that: every 100 parts of the feed additive for large yellow croaker female fish contains 15 parts of Chinese herbal medicine preparation, 1.5 parts of resveratrol and the balance of sepiolite.
Example 3
This example differs from example 1 only in that: every 100 parts of the feed additive for large yellow croaker and female fish contains 20 parts of Chinese herbal medicine preparation, 2.5 parts of resveratrol and the balance of sepiolite.
Comparative example 1
This comparative example differs from example 1 in that: every 100 parts of the feed additive for large yellow croaker and female fish contains 15 parts of Chinese herbal medicine preparation and the balance sepiolite.
Comparative example 2
This comparative example differs from example 1 in that: every 100 parts of the feed additive for large yellow croaker female fish contains 1.5 parts of resveratrol and the balance of sepiolite.
Comparative example 3
This comparative example differs from example 1 in that: every 100 parts of the feed additive for female large yellow croakers contains 1.5 parts of resveratrol, 15 parts of rheum officinale and the balance of sepiolite.
Comparative example 4
This comparative example differs from example 1 in that: every 100 parts of the feed additive for large yellow croaker and female fish contains 1.5 parts of resveratrol and 15 parts of coptis chinensis, and the balance is sepiolite.
Comparative example 5
This comparative example differs from example 1 in that: every 100 parts of the feed additive for large yellow croaker female fish comprises 1.5 parts of resveratrol, 15 parts of liquorice and the balance of sepiolite.
Comparative example 6
This comparative example differs from example 1 in that: every 100 parts of the feed additive for large yellow croaker and female fish contains 1.5 parts of resveratrol and 15 parts of Chinese herbal medicine preparation, and the balance is sepiolite. Wherein, the Chinese herbal medicine preparation is prepared from the following raw materials in parts by weight of 4: 2 and Chinese goldthread.
Comparative example 7
This comparative example differs from example 1 in that: every 100 parts of the feed additive for large yellow croaker and female fish contains 1.5 parts of resveratrol and 15 parts of Chinese herbal medicine preparation, and the balance is sepiolite. Wherein, the Chinese herbal medicine preparation is prepared from the following raw materials in parts by weight of 4: 1, rhubarb and liquorice.
Comparative example 8
This comparative example differs from example 1 in that: every 100 parts of the feed additive for large yellow croaker and female fish contains 1.5 parts of resveratrol and 15 parts of Chinese herbal medicine preparation, and the balance is sepiolite. Wherein, the Chinese herbal medicine preparation is prepared from the following raw materials in percentage by weight of 2: 1, and licorice.
Comparative example 9
This comparative example differs from example 1 in that: every 100 parts of the feed additive for large yellow croaker and female fish contains 1.5 parts of resveratrol and 15 parts of Chinese herbal medicine preparation, and the balance is sepiolite. Wherein, the Chinese herbal medicine preparation is prepared from the following raw materials in percentage by weight of 3: 1: 2, rhubarb, coptis and liquorice.
Test examples
The test adopts single factor design, the formula of each group of daily ration is shown in table 1, the daily ration is processed into particles with the particle size of about 3mm by a small-sized granulator, and the particles are dried at normal temperature and then stored in a refrigerator at 4 ℃ for later use.
The culture experiment was carried out in an offshore floating net cage, and the test fish were cultured in 39 net cages (2m x 2.5m), fed 3 times a day, and fed after being fed with grazing. Domesticating the fish for one week, selecting 1170 tails of large yellow croaker female fish with strong physique and regular specification (average weight is 75 +/-4 g), randomly dividing into 13 groups, repeating 3 groups, and repeating 30 tails each. Wherein 1 control group is fed with basal ration every two weeks during the test period (i.e. the ration of the control group does not contain the feed additive provided by the present application); 3 test groups were fed with the feed additive for large yellow croaker female fish provided in examples 1 to 3 of the present application and a basal diet every two weeks during the test period (examples 1 to 3 correspond to test groups 1 to 3, respectively); 9 comparison groups were fed with basal diet every two weeks and the feed additives for female large yellow croakers provided in comparison groups 1-9 of this application during the test period, and the survival conditions of the female large yellow croakers were recorded. And (3) test period: 4 months in 2019-10 months in 2019.
After the culture experiment is finished, the fish is fasted for 24 hours, the weight gain is calculated by measuring the weight, and then 15 fish are randomly fished from each net cage and the fish with the concentration of 100 mg.L-1MS-222(Sigma, USA) was anesthetized, placed on a ice tray, dissected and its gonadal sample weighed to calculate the gonadal index.
The weight gain rate is (end average weight-initial average weight)/initial average weight x 100%;
gonadal index ═ (gonadal weight/fish weight) × 100%.
TABLE 1 daily ration composition (%)
| Composition of daily ration | Control group | Test or control groups |
| Fish meal | 30 | 30 |
| Bean pulp | 26 | 26 |
| Wheat flour | 22.5 | 22.5 |
| Soybean lecithin | 2 | 2 |
| Fish oil | 7 | 7 |
| Mineral mixture1 | 2 | 2 |
| Vitamin mixture2 | 2 | 2 |
| Microcrystalline cellulose | 8.5 | 8.4 |
| Additive agent | 0 | 0.1 (5 groups of additives respectively) |
| Total of | 100 | 100 |
Note: mineral mixture1The composition (g/kg daily ration) is as follows: MgSO (MgSO)4·7H2O，3.65；CuSO4·5H2O，0.02；FeSO4·7H2O，0.24；ZnSO4·7H2O，0.15；MnSO4·H2O，0.088；CoCl2·6H2O，0.004；Na2SeO3，0.001；Ca(IO3)2·6H2O, 0.0048; microcrystalline cellulose, 15.84.
Vitamin mixture2Composition (mg/kg ration): VA acetate, 16000 IU; VD3, 2500 IU; alpha-tocopherol, 120; menadione Sodium Bisulfite (MSB), 5.1; thiamine hydrochloride, 24.5; riboflavin, 36; pyridoxine, 19.8; cyanocobalamin, 0.1; calcium D-pantothenate, 58.8; niacin, 198; folic acid, 19.6; biotin, 1.2; inositol, 784; VC phosphate, 700.
The test results are shown in table 2.
TABLE 2 comparison of the survival rate, weight gain rate and gonadal index of female large yellow croakers in different treatment groups
| Test group 1 | Test group 2 | Test group 3 | |
| The survival rate is high | 94.5a | 94.7a | 93.6a |
| The weight gain rate% | 234a | 241a | 237a |
| Sex gland index of female fish% | 4.83c | 4.36c | 4.74c |
TABLE 2 comparison of the survival rate, weight gain rate and gonadal index of female large yellow croakers in different treatment groups
Note: the same row superscript without the same letter indicates that the difference is significant (P <0.05), the following.
As can be seen from Table 2, the survival rate and the weight gain rate of the large yellow croaker female fish in the test groups 1-3 are significantly higher than those in the control group (P <0.05), which shows that the large yellow croaker female fish feed additive provided by the embodiment of the application can promote the growth of the large yellow croaker and improve the survival rate. The survival rate and the weight gain rate of the large yellow croaker female fish of the comparison groups 1-8 are obviously lower than those of the test groups 1-3(P is less than 0.05), and the difference with the comparison groups is not obvious, so that the effect of improving the survival rate and the weight gain rate of the large yellow croaker female fish can be well achieved by using the resveratrol, the rheum officinale, the coptis chinensis and the liquorice together in the feed additive for the large yellow croaker female fish provided by the application. The survival rate and the weight gain rate of the large yellow croaker female fish of the comparison group 9 are lower than those of the test groups 1-3(P is less than 0.05), which shows that the rhubarb, the coptis root and the liquorice in the Chinese herbal medicine preparation need to be mixed according to a specific proportion range to obtain good effect.
Meanwhile, the gonadal indexes of the female large yellow croakers in the test groups 1 to 3 are remarkably reduced (P is less than 0.05) compared with those in the control group, which shows that the feed additive for the female large yellow croakers provided by the embodiment of the application can inhibit the gonadal development of the female large yellow croakers. The difference between the comparison groups 1-2 and the comparison group is not significant (P is more than 0.05), the gonadal index of the comparison groups 3-8 is still significantly lower than that of the test group (P is less than 0.05), and the result shows that the feed additive for the large yellow croaker female fish provided by the application can achieve a good effect of inhibiting the gonadal development of the large yellow croaker female fish by using resveratrol, rhubarb, coptis chinensis and liquorice together. The sex gland indexes of the female fishes among the comparison groups 3-8 have no obvious difference, which shows that the feed additive has the function of inhibiting the sex gland development of the female fishes of the large yellow croakers, is not simple in superposition of the components, has a certain synergistic effect among the components, and can achieve a good effect of inhibiting the sex gland development after the components are compatible for use. The gonadal index of the comparison group 9 of the large yellow croaker is higher than that of the test group 1-3(P is less than 0.05), which shows that the rhubarb, the coptis root and the liquorice in the Chinese herbal medicine preparation need to be mixed according to a specific proportion range to obtain good effect.
In summary, the rhubarb, the coptis chinensis and the liquorice are compounded and are matched with the resveratrol for breeding the large yellow croaker female fish, so that the gonadal index of the large yellow croaker female fish can be effectively reduced, the good effect of inhibiting the gonadal development of the large yellow croaker female fish is achieved, the weight gain rate and the survival rate of the large yellow croaker female fish can be improved, and the breeding benefit is greatly improved. The preparation method of the feed additive is simple and rapid, and can be used for industrial production.
The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The feed additive for the large yellow croaker female fish is characterized by comprising, by weight, 10-20 parts of Chinese herbal medicine preparation, 0.5-2.5 parts of resveratrol and the balance of carrier per 100 parts of the feed additive for the large yellow croaker female fish; the Chinese herbal medicine preparation comprises raw materials of rhubarb, coptis and liquorice.
2. The feed additive for large yellow croaker female fish according to claim 1, wherein each 100 parts of the feed additive for large yellow croaker female fish comprises 15 to 20 parts of the Chinese herbal medicine preparation, 1.5 to 2.5 parts of the resveratrol and the balance of the carrier;
preferably, every 100 parts of the large yellow croaker female fish feed additive comprises 15 parts of the Chinese herbal medicine preparation, 1.5 parts of resveratrol and the balance of the carrier.
3. The feed additive for large yellow croaker female fish according to claim 1 or 2, wherein the raw materials of the Chinese herbal medicine preparation comprise, by weight, 4: 2: 1 of the rhubarb, the coptis root and the liquorice.
4. The feed supplement for large yellow croaker females as claimed in claim 3, wherein said carrier comprises sepiolite.
5. The method for preparing a feed additive for large yellow croaker female fish according to any one of claims 1 to 4, comprising the steps of: mixing the Chinese herbal medicine preparation, the resveratrol and the carrier according to a ratio.
6. The method of claim 5, wherein the herbal formulation is prepared by a method comprising: pulverizing the rhubarb, the coptis root and the licorice and mixing.
7. The method according to claim 6, wherein the pulverization is carried out by ultrafine pulverization.
8. The method as set forth in claim 6, wherein the crushed material is passed through a 120-mesh sieve of 100 meshes.
9. The method of claim 6, further comprising drying the rhubarb, the coptis root and the licorice before the pulverization;
preferably, the drying temperature of the rhubarb, the coptis chinensis and the liquorice is 60-65 ℃, and the drying time is 8-9 h.
10. Use of the feed additive for female large yellow croaker according to any one of claims 1 to 5 for inhibiting gonadal development of female large yellow croaker;
preferably, the large yellow croaker female fish feed additive is used for preparing a large yellow croaker female fish feed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010762492.3A CN111802536B (en) | 2020-07-31 | 2020-07-31 | Feed additive for large yellow croaker female fish and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010762492.3A CN111802536B (en) | 2020-07-31 | 2020-07-31 | Feed additive for large yellow croaker female fish and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111802536A true CN111802536A (en) | 2020-10-23 |
| CN111802536B CN111802536B (en) | 2022-05-20 |
Family
ID=72863459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010762492.3A Active CN111802536B (en) | 2020-07-31 | 2020-07-31 | Feed additive for large yellow croaker female fish and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111802536B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112877277A (en) * | 2021-03-12 | 2021-06-01 | 集美大学 | Large yellow croaker ovary tissue cell line and application thereof |
| CN113040297A (en) * | 2021-04-27 | 2021-06-29 | 深圳市沙利文生物科技有限公司 | Environment-friendly fish feed additive and preparation method thereof |
| CN113749196A (en) * | 2021-10-09 | 2021-12-07 | 中国水产科学研究院南海水产研究所 | Premix for Epinephelus coioides, feed, preparation method and application of premix |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104431368A (en) * | 2014-12-15 | 2015-03-25 | 中国水产科学研究院长江水产研究所 | Compound feed additive for promoting healthy growth of fishes and preparation method |
| CN108157684A (en) * | 2018-01-25 | 2018-06-15 | 中国海洋大学 | A kind of feed addictive for improving Larimichthys crocea oxidation resistance and preparation method thereof |
-
2020
- 2020-07-31 CN CN202010762492.3A patent/CN111802536B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104431368A (en) * | 2014-12-15 | 2015-03-25 | 中国水产科学研究院长江水产研究所 | Compound feed additive for promoting healthy growth of fishes and preparation method |
| CN108157684A (en) * | 2018-01-25 | 2018-06-15 | 中国海洋大学 | A kind of feed addictive for improving Larimichthys crocea oxidation resistance and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112877277A (en) * | 2021-03-12 | 2021-06-01 | 集美大学 | Large yellow croaker ovary tissue cell line and application thereof |
| CN112877277B (en) * | 2021-03-12 | 2022-09-23 | 集美大学 | Large yellow croaker ovary tissue cell line and application thereof |
| CN113040297A (en) * | 2021-04-27 | 2021-06-29 | 深圳市沙利文生物科技有限公司 | Environment-friendly fish feed additive and preparation method thereof |
| CN113749196A (en) * | 2021-10-09 | 2021-12-07 | 中国水产科学研究院南海水产研究所 | Premix for Epinephelus coioides, feed, preparation method and application of premix |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111802536B (en) | 2022-05-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111802536B (en) | Feed additive for large yellow croaker female fish and preparation method and application thereof | |
| CN103284017B (en) | Application of yucca in compound feed for megalobrama amblycephala and formula of feed | |
| CN103340308B (en) | Application of fibrauretine in cyprinus carpio compound feed and formula of cyprinus carpio compound feed containing fibrauretine | |
| CN104171648A (en) | Feed additive capable of promoting liver health of fish | |
| CN102771675A (en) | Organic-selenium-rich turtle feed for improving turtle immunity | |
| CN104543491A (en) | Concentrate mixed granular material for breast-feeding female bamboo rats and preparation method of concentrate mixed granular material | |
| CN112970972A (en) | A functional fish feed containing rhizoma Amorphophalli polysaccharide | |
| CN107927458A (en) | A kind of immunity enhancement type penaeus vannamei boone feed and preparation method thereof | |
| CN102499328A (en) | Soft-shelled turtle rich in organic selenium and culture method thereof | |
| CN102258158B (en) | Grass carp feed containing fermented rapeseed meal and fermented cottonseed meal and preparation method thereof | |
| CN111772064A (en) | Compound feed for preventing rotten body disease of raw fish and application thereof | |
| CN109170328B (en) | Compound feed for cage-rearing laying ducks and preparation method thereof | |
| CN105360729B (en) | A kind of functional feed and preparation method thereof inhibiting Larimichthys crocea gonad development | |
| CN111165683A (en) | Traditional Chinese medicine health-care compound feed for shrimps and crabs and preparation process thereof | |
| CN110840963A (en) | Chinese herbal medicine additive and artificial mixed feed for improving intestinal health of loaches and preparation method thereof | |
| CN104273345B (en) | A kind of Macrobrachium rosenbergii composite immune reinforcing agent and its application | |
| CN103392934B (en) | Full-balanced powder forage for adult stichopus japonicus | |
| CN113907216A (en) | Chinese herbal medicine feed additive for preventing and treating liver and gall syndrome of grass carp | |
| CN109601706B (en) | Compound additive for improving growth and health of grass carps and preparation method and application thereof | |
| CN108522819A (en) | A kind of compound pig feed and preparation method thereof for improving immunity, promoting growth | |
| CN114557986A (en) | Turmeric composition, preparation method thereof and application thereof in tilapia culture | |
| EP3685676B1 (en) | Zero-starch and binder-free starter compound feed for fish, and preparation method thereof | |
| CN112617008A (en) | Feed for wild schizothorax prenanti seedlings | |
| CN111743052A (en) | Compound feed for preventing white spot virus syndrome of penaeus monodon and preparation method and application thereof | |
| CN111602757B (en) | Feed capable of reducing feed protein consumption of pelteobagrus fulvidraco as well as preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20211101 Address after: 363000 intersection of Xingting Road and Baolian Road, Jinfeng Economic Development Zone, Xiangcheng District, Zhangzhou City, Fujian Province Applicant after: FUJIAN AONONG BIOLOGICAL TECHNOLOGY GROUP Co.,Ltd. Applicant after: MAOMING AOXIN BIOTECHNOLOGY CO.,LTD. Applicant after: Fujian Aokai Biotechnology Co.,Ltd. Address before: 363000 intersection of Xingting Road and Baolian Road, Jinfeng Economic Development Zone, Xiangcheng District, Zhangzhou City, Fujian Province Applicant before: FUJIAN AONONG BIOLOGICAL TECHNOLOGY GROUP Co.,Ltd. Applicant before: MAOMING AOXIN BIOTECHNOLOGY CO.,LTD. Applicant before: Fujian Aoke Biotechnology Co.,Ltd. |
|
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20220424 Address after: 363000 intersection of Xingting Road and Baolian Road, Jinfeng Economic Development Zone, Xiangcheng District, Zhangzhou City, Fujian Province Applicant after: FUJIAN AONONG BIOLOGICAL TECHNOLOGY GROUP Co.,Ltd. Applicant after: MAOMING AOXIN BIOTECHNOLOGY CO.,LTD. Applicant after: YUNNAN KUAIDADUO ANIMAL HUSBANDRY TECHNOLOGY Co.,Ltd. Applicant after: Fujian Aokai Biotechnology Co.,Ltd. Address before: 363000 intersection of Xingting Road and Baolian Road, Jinfeng Economic Development Zone, Xiangcheng District, Zhangzhou City, Fujian Province Applicant before: FUJIAN AONONG BIOLOGICAL TECHNOLOGY GROUP Co.,Ltd. Applicant before: MAOMING AOXIN BIOTECHNOLOGY CO.,LTD. Applicant before: Fujian Aokai Biotechnology Co.,Ltd. |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |